Aftertreated Polymer (e.g., Grafting, Blocking, Etc.) Patents (Class 424/78.17)
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Patent number: 8349309Abstract: A pharmaceutically-active polymeric compound of the general formula (I), Y-[Yn-LINK B-X]m-LINK B??(I) wherein (i) X is a coupled biological coupling agent of the general formula (II) Bio-LINK A-Bio??(II) wherein Bio is a biologically active agent fragment or precursor thereof linked to LINK A through a hydrolysable covalent bond; and LINK A is a coupled central flexible linear first segment of <2000 theoretical molecular weight linked to each of said Bio fragments; (ii) Y is LINK B-OLIGO; wherein (a) LINK B is a coupled second segment linking one OLIGO to another OLIGO and an OLIGO to X or precursor thereof; and (b) OLIGO is a short length of polymer segment having a molecular weight of less than 5,000 and comprising less than 100 monomeric repeating units; (iii) m is 1-40; and (iv) n is selected from 2-50. The compounds are useful as biomaterials, particularly, providing antibacterial activity in vivo.Type: GrantFiled: June 3, 2010Date of Patent: January 8, 2013Assignee: Interface Biologics Inc.Inventors: J. Paul Santerre, Mei Li
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Patent number: 8349306Abstract: The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.Type: GrantFiled: October 10, 2007Date of Patent: January 8, 2013Assignee: Samyang Biopharmaceuticals CorporationInventors: Min Hyo Seo, Sa-Won Lee, Myung-Han Hyun, Jeong-Il Yu, Dong-Hoon Chang, Hye-Jeong Yoon, Jeong-Kyung Kim
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Publication number: 20130004455Abstract: Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.Type: ApplicationFiled: June 30, 2011Publication date: January 3, 2013Applicant: Korea Institute of Science and TechnologyInventors: Soo-Chang SONG, Thrimoorthy Potta, Mi-Ran Park
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Patent number: 8343523Abstract: An alcohol- or glycol-soluble, water-insoluble, disinfectant composition and a method of using the same for disinfecting and for providing a prolonged antimicrobial property to a variety of surfaces, including skin. The composition comprises at least one alcohol or glycol and an antimicrobial polymer that is capable of imparting an antimicrobial property to a surface without the use of a metal or a metal-containing compound. The composition is applied to a surface and allowed to evaporate leaving a coating of antimicrobial polymer. Alternatively, the composition is incorporated into or within the substrate.Type: GrantFiled: January 8, 2009Date of Patent: January 1, 2013Assignee: Quick-Med Technologies, Inc.Inventors: William Toreki, Gerald Olderman, Rustom S. Kanga
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Patent number: 8343084Abstract: A wound closure apparatus and associated methods are provided which utilize blood fluid by activating the clotting cascade of blood fluid within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. An apparatus for providing ways of inhibiting anticoagulating agents and slowing fibrin clot degradation are also disclosed. Kits are also disclosed. The invention provides a clotting cascade initiation apparatus including a substantially enclosed sterile containment chamber within which an aliquot of blood fluid, either autologous or from donor sources, can be received and retained. In preferred embodiments, the sterile containment chamber further includes a heparin binding agent which will bind heparin and remove it from the blood fluid. In further embodiments, the containment chamber will also include a procoagulating agent, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber.Type: GrantFiled: October 29, 2010Date of Patent: January 1, 2013Assignee: Closys CorporationInventors: Karol L. Nowakowski, James E. Olson, Edward T. Joseph, Daniel G. Ericson
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Publication number: 20120328555Abstract: The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety. The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety.Type: ApplicationFiled: December 10, 2010Publication date: December 27, 2012Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Rameshwar Patil, Eggehard Holler, Keith L. Black, Julia Y. Ljubimova
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Publication number: 20120318701Abstract: The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.Type: ApplicationFiled: August 21, 2012Publication date: December 20, 2012Applicant: Nektar TherapeuticsInventors: Sean M. Culbertson, Samuel P. McManus
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Publication number: 20120321583Abstract: A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight ?5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.Type: ApplicationFiled: June 11, 2012Publication date: December 20, 2012Applicant: Mersana Therapeutics, Inc.Inventors: Aleksandr Yurkovetskiy, Mao Yin, Timothy B. Lowinger, Joshua D. Thomas, Charles E. Hammond, Cheri A. Stevenson, Natalya D. Bodyak, Patrick R. Conlon, Dmitry R. Gumerov
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Publication number: 20120315239Abstract: Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates.Type: ApplicationFiled: May 3, 2012Publication date: December 13, 2012Applicant: University of Washington through its Center for CommercializationInventors: Shaoyi Jiang, Andrew Keefe, Hong Xue
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Patent number: 8329157Abstract: Compositions comprising poly(hydroxyalkanoates) and agents for use with medical articles are described.Type: GrantFiled: July 15, 2011Date of Patent: December 11, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Stephen D. Pacetti
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Patent number: 8329155Abstract: The present invention provides novel antimicrobial agents that are quaternary ammonium functionalized glycodendrimers. In one embodiment, the quaternary ammonium functionalized glycodendrimers are compounds of Formula (I): (Q+?-S-L)z-DnX? wherein: D is a dendrimer; n is the generation number of the functionalized dendrimer; z is an integer less than or equal to 2(n+2); L is a linking group; Q+ represents a quaternary ammonium moiety; and S represents a carbohydrate moiety. The present invention further provides formulations containing the antimicrobial agents of the invention, methods of making the agents and formulations of the invention, and methods of using the same as effective and/or broad spectrum antimicrobial agents. The agents and formulations of the invention find use in medicine, for the treatment of various inflammatory conditions or diseases, for example, and have numerous industrial applications.Type: GrantFiled: March 12, 2007Date of Patent: December 11, 2012Assignees: Montana State University, Queen's College of the City University of New YorkInventors: Mary Cloninger, Robert Engel
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Patent number: 8329199Abstract: Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.Type: GrantFiled: May 18, 2012Date of Patent: December 11, 2012Assignee: Nitto Denko CorporationInventors: Sang Van, Yucheng Song, Xinghe Wang, Zheng Hou, Zhongling Feng, Gang Zhao, Lei Yu
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Patent number: 8329158Abstract: Embodiments of the present invention provides medical devices comprising poly(hydroxyalkanoates) and agents.Type: GrantFiled: July 15, 2011Date of Patent: December 11, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Stephen D. Pacetti
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Patent number: 8323669Abstract: [Problems] To provide a novel taxane derivative which can release the medicinal substance in a bioenzyme-independent manner, is expected to have an effective therapeutic efficacy, and has a water-solubility. [Means for Solving Problems] Disclosed is a polymer conjugate of a taxane, which comprises a polymer having a polyethylene glycol moiety and two or more succinic acid monoamide moieties and a taxane, wherein a carboxylate group in the polymer and an alcoholic hydroxyl group in the taxane are bound to each other via an ester bonding.Type: GrantFiled: March 22, 2007Date of Patent: December 4, 2012Assignee: Nippon Kayaku Kabushiki KaishaInventors: Masayuki Kitagawa, Keizou Ishikawa, Takeshi Onda
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Patent number: 8323632Abstract: The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.Type: GrantFiled: June 2, 2011Date of Patent: December 4, 2012Assignee: Nektar TherapeuticsInventors: Xuan Zhao, Zhongxu Ren, Kazunori Emoto
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Patent number: 8318145Abstract: Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.Type: GrantFiled: March 19, 2010Date of Patent: November 27, 2012Assignee: Nektar TherapeuticsInventors: Xuan Zhao, Michael D. Bentley, Zhongxu Ren, Tacey X. Viegas
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Publication number: 20120282186Abstract: The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.Type: ApplicationFiled: November 1, 2010Publication date: November 8, 2012Applicant: Northwestern UniversityInventors: Chad A. Mirkin, David A. Giljohann, Weston L. Daniel, Joshua I. Cutler, Ke Zhang, Dan Zheng
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Publication number: 20120263672Abstract: Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.Type: ApplicationFiled: April 13, 2012Publication date: October 18, 2012Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Natalie Artzi, Elazer R. Edelman, Núria Oliva Jorge, Maria Carcolé Solanes
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Patent number: 8287890Abstract: A hydrophilic, lubricious coating for a substrate includes a first coating layer having a cross-linked polyurethane or polyurea complexed with poly(ethylene oxide) formed by reacting a mixture of an isocyanate, a polyol or polyamine, and a poly(ethylene oxide), and a second coating layer having a cross-linked polyurethane or polyurea complexed with polyvinylpyrrolidone formed by reacting a mixture of an isocyanate, a polyol or polyamine, and a polyvinylpyrrolidone. The first layer is substantially covered by the second layer and the second layer at least partially interpenetrates the first layer. The coating is provided by applying the first coating layer, curing to provide a cross-linked polyurethane or polyurea/poly(ethylene oxide) coating, applying the second layer, and curing to provide a cross-linked polyurethane or polyurea/polyvinylpyrrolidone coating.Type: GrantFiled: December 15, 2009Date of Patent: October 16, 2012Assignee: C.R. Bard, Inc.Inventor: Richard K. Elton
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Patent number: 8287910Abstract: The present invention provides micelles having a polynucleotide encapsulated therein, the micelle comprising copolymers comprising hydrophobic moieties in a cationic complexing block. The invention further provides methods of preparing and using said micelles, and compositions thereof.Type: GrantFiled: April 29, 2010Date of Patent: October 16, 2012Assignee: Intezyne Technologies, Inc.Inventors: Janni Mirosevich, Gregoire Cardoen, Kevin N. Sill, Habib Skaff
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Publication number: 20120258162Abstract: Disclosed are methods and apparatuses for delivery of bioactive molecules. The drug delivery systems include an implantable medical device which significantly reduces or suppresses adverse biological responses associated with implantable devices and also promotes vascularization in tissues surrounding the implanted device. The disclosure also relates to drug delivery systems designed to vary the rate of delivery of bioactive molecules with a change in the physiological environment.Type: ApplicationFiled: April 7, 2011Publication date: October 11, 2012Inventor: Mark A. Tapsak
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Publication number: 20120258068Abstract: Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being cross-linked by non-covalent and/or covalent cross-linking. Compositions-of-matter comprising cross-linked conjugates are provided herein, as well as processes for producing same. Methods of controlling a physical property of compositions-of-matter are also provided herein. The conjugates and compositions-of-matter may be used for various applications, such as cell growth, tissue formation, and treatment of disorders characterized by tissue damage or loss, as described herein.Type: ApplicationFiled: December 16, 2010Publication date: October 11, 2012Applicant: Regentis Biomaterials Ltd.Inventors: Dror Seliktar, Shachaf Yonatan
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Publication number: 20120258069Abstract: Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.Type: ApplicationFiled: June 8, 2011Publication date: October 11, 2012Inventors: Maria Alexander-Bridges, Shaker A. Mousa, Paul J. Davis
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Publication number: 20120258042Abstract: The combined use of a TGF-? signaling inhibitor and an antitumor active substance or an imaging agent modified by a drug-encapsulating macromolecular micelle, or the like, is provided. The selective delivery capability of the antitumor active substance or the imaging agent to the target is improved, increasing the antitumoral activity in the target.Type: ApplicationFiled: February 21, 2012Publication date: October 11, 2012Inventors: Kazunori KATAOKA, Kohei MIYAZONO, Mitsunobu KANO, Younsoo BAE, Nobuhiro NISHIYAMA, Kosei HIRAKAWA, Masakazu YASHIRO, Manabu Node
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Patent number: 8283434Abstract: Methods for preparing a poly(ether carbonates) of the formula HO—[(CH2CH2—O)n—CO2]m—(CH2CH2—O)n—H are provided. The method comprises polymerizing an activated oligomer of the formula of H—O—(CH2CH2—O)n—CO2—Z, where Z is reactive leaving group.Type: GrantFiled: January 5, 2012Date of Patent: October 9, 2012Assignee: Nektar TherapeuticsInventors: J. Milton Harris, Michael David Bentley, Xuan Zhao, Xiaoming Shen
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Patent number: 8282911Abstract: The present relates to the field of dental and bone surgery. In particular, the invention relates to fibrous pharmaceutical compositions; fibrous webs, yarns and woven fabrics of such pharmaceutical compositions; to implant material essentially consisting of fibrous pharmaceutical compositions; to the manufacturing and use of such fibers/webs/implant materials.Type: GrantFiled: October 23, 2006Date of Patent: October 9, 2012Assignees: ETH Zürich, Universitat ZürichInventors: Jan W. Stark, Oliver Schneider, Stefan Loher, Tobias Brunner, Marc Simonet, Patrick Schmidlin, Robert N. Grass
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Publication number: 20120251592Abstract: The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.Type: ApplicationFiled: May 15, 2012Publication date: October 4, 2012Applicants: The State of Oregon Acting by & through the State Board of Higher Ed. on Behalf of Oregon State Univ, ALLVIVO VASCULAR, INC.Inventors: Jennifer A. Neff, Joseph McGuire, Pranav R. Joshi
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Publication number: 20120251607Abstract: A composition of matter comprises a cationic polymer comprising a polycarbonate chain fragment, the polycarbonate chain fragment comprising a repeat unit comprising a side chain moiety containing a quaternary amine group; and a non-charged polymer comprising a polyester chain segment and a poly(alkylene oxide) chain segment; wherein i) the cationic polymer and the non-charged polymer are amphiphilic and biocompatible, ii) the cationic polymer and the non-charged polymer form a mixed complex by non-covalent interactions in water, and iii) the mixed complex is a more effective antimicrobial agent against at least a Gram-negative microbe compared to the cationic polymer and the non-charged polymer alone when tested using otherwise identical conditions.Type: ApplicationFiled: March 31, 2011Publication date: October 4, 2012Inventors: Daniel J. Coady, Kazuki Fukushima, James L. Hedrick, Yi Yan Yang
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Patent number: 8273339Abstract: Provided herein are water-soluble polymer conjugates and polymer-based compositions of antimicrobial agents. Also provided are methods for synthesizing and administering such conjugates and compositions.Type: GrantFiled: April 11, 2006Date of Patent: September 25, 2012Assignee: Nektar TherapeuticsInventors: Mary J. Bossard, Stacy Mitchell
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Patent number: 8268301Abstract: Cationic polymers hydrolyzable to zwitterionic polymers, monomers for making the cationic polymers, surfaces that include the polymers, therapeutic agent delivery systems that include the cationic polymers, methods for administering a therapeutic agent using the delivery systems, and methods for making and using the cationic polymers, monomers, surfaces, and therapeutic agent delivery systems.Type: GrantFiled: November 19, 2008Date of Patent: September 18, 2012Assignee: University of WashingtonInventors: Shaoyi Jiang, Shengfu Chen, Zheng Zhang, Gang Cheng, Hong Xue, Louisa R. Carr
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Publication number: 20120230917Abstract: Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.Type: ApplicationFiled: May 18, 2012Publication date: September 13, 2012Applicant: NITTO DENKO CORPORATIONInventors: Sang Van, Yucheng Song, Xinghe Wang, Zheng Hou, Zhongling Feng, Gang Zhao, Lei Yu
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Publication number: 20120231044Abstract: A vaccine formulation as disclosed which is comprised of a pharmaceutically acceptable carrier in a plurality of particles with mannose on their surface. The particles are comprised of a biocompatible polymer which maybe a co-polymer such as PLGA combined with a peptide of a sequence which corresponds to a sequence on a surface of a pathogen. A plurality of different groups of particles are provided in the formulation wherein the particles within any single group include peptides of identical amino acid sequence. The particles are sized such that they are sufficiently large so as to prevent more than a single particle from being presented to a single immune system cell.Type: ApplicationFiled: March 12, 2012Publication date: September 13, 2012Inventors: Charles Vincent Taylor Herst, Reid M. Rubsamen
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Patent number: 8263062Abstract: Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.Type: GrantFiled: February 22, 2010Date of Patent: September 11, 2012Assignee: Nektar TherapeuticsInventors: Xuan Zhao, Michael D. Bentley, Zhongxu Ren, Tacey X. Viegas
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Patent number: 8257735Abstract: The instant invention is drawn to a hepatocyte targeted composition comprising a mixture of free recombinant human insulin isophane and free Recombinant human regular insulin insulin and a mixture of recombinant human insulin isophane and Recombinant human regular insulin insulin associated with a water insoluble target molecule complex, wherein the complex comprises multiple linked individual units and a supra-molecular lipid construct matrix. Recombinant human insulin isophane and Recombinant human regular insulin insulin are present within the complex in at least one form wherein the recombinant human insulin isophane and Recombinant human regular insulin insulin have regions of positive charge which interacts with a negative charge on the complex. The invention also includes methods for the manufacture of the composition and methods of managing blood glucose levels in individuals with Type I and Type II diabetes.Type: GrantFiled: November 23, 2010Date of Patent: September 4, 2012Assignee: SDG, IncInventors: John R. Lau, W. Blair Geho
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Patent number: 8257690Abstract: Tissue adhesives formed by crosslinking albumin and/or gelatin with certain polyamines and/or polycarboxylates using a water-soluble carbodiimide are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.Type: GrantFiled: October 14, 2010Date of Patent: September 4, 2012Assignee: Actamax Surgical Materials, LLCInventor: Henry Keith Chenault
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Patent number: 8252275Abstract: The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.Type: GrantFiled: June 16, 2006Date of Patent: August 28, 2012Assignee: Nektar TherapeuticsInventors: Michael D. Bentley, Sean Culbertson, Samuel P. McManus
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Publication number: 20120213854Abstract: Described herein are methods for treating a subject with combinations of polymer-agent particles and cyclodextrin polymer agent conjugates. The methods herein may be used to treat subjects identified with cancer, cardiovascular disorders, autoimmune disorders, or inflammatory disorders. Also described herein are compositions, dosage forms, and kits comprising polymer-agent particles and cyclodextrin polymer agent conjugates.Type: ApplicationFiled: September 29, 2011Publication date: August 23, 2012Inventor: Oliver S. Fetzer
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Patent number: 8246991Abstract: Disclosed herein are biocompatible and biodegradable polymers which are useful in tissue engineering; wound healing, coatings, and drug delivery, said polymers comprising one or more ECM-mimetic peptides and one or more biodegradable moieties, wherein the moieties do not comprise an amino acid or residue thereof. Further disclosed herein are methods for making and using the disclosed biocompatible polymers.Type: GrantFiled: May 11, 2009Date of Patent: August 21, 2012Assignee: SurModics Pharmaceuticals, Inc.Inventor: Asima Pattanaik
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Patent number: 8241668Abstract: Polymers (i.e. polyesters, polyamides, and polythioesters or a mixture thereof) which degrade hydrolytically into biologically active compounds are provided. Methods of producing these polymers, intermediates useful for preparing these polymers, and methods of using these polymers to deliver biologically active compounds to a host are also provided.Type: GrantFiled: December 13, 2007Date of Patent: August 14, 2012Assignee: Rutgers, the State University of New JerseyInventor: Kathryn E. Uhrich
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Patent number: 8241619Abstract: Disclosed are hindered amine nitric oxide (NO) donating polymers for coating implantable medical devices. The polymers include sterically hindered secondary amines that do not react with monomer carbonyls or electrophilic alkenes, facilitating the synthesis of the NO donating polymers. The polymers are coated on implantable medical devices, providing anti-restenosis therapy by the release of NO at the implantation site.Type: GrantFiled: May 15, 2006Date of Patent: August 14, 2012Assignee: Medtronic Vascular, Inc.Inventors: Peiwen Cheng, Mingfei Chen, Kishore Udipi
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Patent number: 8241620Abstract: Physically and chemically stable, water-soluble, amphiphilic polymer-PDGF complex, characterized in that the amphiphilic polymers include a hydrophilic polymeric backbone functionalized with hydrophobic substituents and hydrophilic groups.Type: GrantFiled: May 23, 2011Date of Patent: August 14, 2012Assignee: AdociaInventors: Latifa Dahri-Correia, Jose Correia, Guy Dubreucq, David Duracher, Remi Soula, Olivier Soula, Gerard Soula
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Publication number: 20120195846Abstract: A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion.Type: ApplicationFiled: April 13, 2012Publication date: August 2, 2012Applicant: Nektar Therapeutics AL, CorporationInventors: J. Milton Harris, Xuan Zhao
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Patent number: 8232320Abstract: The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs.Type: GrantFiled: October 30, 2007Date of Patent: July 31, 2012Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Tarek Hamouda, Amy Shih, Andrzej Myc
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Publication number: 20120189554Abstract: Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.Type: ApplicationFiled: April 2, 2012Publication date: July 26, 2012Applicant: Nitto Denko CorporationInventors: Lei Yu, Gang Zhao, Sang Van, Sanjib Kumar Das, Fu Chen, Yi Jin, Xiaoli Fu
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Patent number: 8221790Abstract: Polymers (i.e. polyesters, polyamides, and polythioesters or a mixture thereof) which degrade hydrolytically into biologically active compounds are provided. Methods of producing these polymers, intermediates useful for preparing these polymers, and methods of using these polymers to deliver biologically active compounds to a host are also provided.Type: GrantFiled: December 13, 2007Date of Patent: July 17, 2012Assignee: Rutgers, The State University of New JerseyInventor: Kathryn E. Uhrich
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Publication number: 20120177594Abstract: The present invention aims to provide a gene delivery system with higher safety and higher sustainability, which is effective for the treatment of ischemic diseases and the like, and the like. The present invention provides a pharmaceutical composition containing, as an active ingredient, a polyanionic substance that suppresses expression of PHD2, and containing a polyion complex of the polyanionic substance and a polycation chargeable polymer.Type: ApplicationFiled: July 22, 2010Publication date: July 12, 2012Inventors: Kazunori Kataoka, Shourong Wu, Nobuhiro Nishiyama, Keiji Itaka, Hiroyuki Koyama, Takuya Hashimoto, Yuichi Tei
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Publication number: 20120177592Abstract: A method of developing degradable linear poly(ethylene glycol) PEG (DPEG) with multiple functioning capacities, which can be used as drug carriers for cancer cell delivery. A DPEG may be effective in targeting cancerous tumors through an enhanced permeation and retention effect (EPR). The DPEG will then degrade in the acidic extracellular fluid of solid tumors leading to fast cellular internalizations, finally degrading in the lysosome for efficient renal clearance. These may be used in conjunction with drugs and/or targeting groups. Furthermore, DPEGs are thermoresponsive, on an as needed basis, making them useful for in vivo application.Type: ApplicationFiled: May 30, 2008Publication date: July 12, 2012Applicant: UNIVERSITY OF WYOMINGInventors: Maciej Radosz, Youqing Shen
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Publication number: 20120177593Abstract: The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.Type: ApplicationFiled: July 20, 2010Publication date: July 12, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James R. Baker, JR., Yuehua Zhang, Thommey P. Thomas, Ankur Mahesh Desai
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Publication number: 20120171152Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.Type: ApplicationFiled: March 9, 2012Publication date: July 5, 2012Inventors: Alexander V. Kabanov, Xiang Yi, Sarguel V. Vinogradov, William A. Banks
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Publication number: 20120171154Abstract: Disclosed is a method for preparing a composition enriched for receptors (typically molecular impringet polymers, MIPs) that bind an agent, where said receptors each specifically bind at least two discrete sites on said agent, by subjecting a sample of receptors to a first step of affinity purification with the agent where one binding site on the agent is non-accessible for binding to the receptors and subsequently subjecting the purified receptors to at least one further step of affinity purification with the agent where a second binding site on the agent is non-accessible.Type: ApplicationFiled: September 16, 2010Publication date: July 5, 2012Applicant: Mipsalus ApSInventors: Nicolas Otto Krogh, Klaus Gregorius