Polymer From Ethylenic Monomers Only Patents (Class 424/78.31)
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Publication number: 20020028229Abstract: The invention provides antimicrobial compositions which contain a phenol complex with a film forming complex of a polycarboxylic acid and a microbicide containing at least two quaternary amine groups.Type: ApplicationFiled: January 25, 2000Publication date: March 7, 2002Inventors: John Lezdey, Jarett R. Lezdey
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Patent number: 6352704Abstract: A sterile or non-sterile flavored monomeric adhesive composition includes a flavoring additive and a monomer. The composition can be applied, for example, to skin or the inside of the mouth. A method of making a sterile, flavored adhesive composition includes placing a mixture of a polymerizable adhesive monomer and a flavoring additive in a container, sealing the container, and sterilizing the mixture and the container. The flavored adhesive composition is particularly useful as a medical adhesive and can include 1,1 -disubstituted ethylene monomers, such as &agr;-cyanoacrylates.Type: GrantFiled: June 30, 1999Date of Patent: March 5, 2002Assignee: Closure Medical CorporationInventors: William S. C. Nicholson, Upvan Narang
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Publication number: 20020018752Abstract: The present invention provides compositions comprising a first component and a second component, wherein the first component includes at least two polymerizable organic monomers, and wherein the second component includes an oligomer of a polymerizable organic monomer, a plasticizer and an opacificant agent, wherein said composition polymerizes upon contact with an anionic environment. The compositions are useful for filling, occluding, partially filling or partially occluding an unfilled volume or space in a mass in an anionic environment. The composition are also useful for ablating diseased or undesired tissue by cutting off the blood supply to the tissue.Type: ApplicationFiled: May 23, 2001Publication date: February 14, 2002Inventors: Robert E. Krall, Charles W. Kerber, Kimberly Knox
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Patent number: 6346241Abstract: A feedstock for feeding to animals is disclosed. The feedstock contains a mixture of feed for animals and shredded tires. Also disclosed is a method of using the feedstock to improve digestive efficiency and control harmful and toxic plants.Type: GrantFiled: July 8, 1999Date of Patent: February 12, 2002Inventors: Charles P. Haymore, Adam Heller
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Publication number: 20020015689Abstract: A bioadhesive composition formed by polymerising a homogeneous aqueous reaction mixture comprising from about 5% to about 50%, by weight of the reaction mixture, of at least one ionic water soluble monomer, from about 10% to about 50%, by weight of the reaction mixture, of at least one plasticiser (other than water), up to about 50%, by weight of the reaction mixture, of at least one non ionic water soluble monomer, up to about 40%, by weight of the reaction mixture, of water, optionally as well as up to about 10%, by weight of the reaction mixture, of at least one surfactant and from about 1% to about 30%, by weight of the reaction mixture, of at least one hydrophobic monomer and/or polymer. An electrolyte may be present, to enhance electrical conductivity, e.g. for use in biomedical electrodes.Type: ApplicationFiled: July 27, 2001Publication date: February 7, 2002Inventors: Hugh Semple Munro, Brian John Tighe
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Patent number: 6335374Abstract: A penetrating concentrate containing a biocidal amount of a biocide uses a penetrating carrier vehicle containing an emulsifiable copolymer of a cyclic diene and a polymerizable, unsaturated glyceride. For biocides, such as iodopropargyl carbamate, which otherwise requires use of significant amounts of co-solvent to disperse, is directly soluble in the copolymer thereby eliminating or at least substantially reducing the need for co-solvents to assure stability of the biocide in the formulation. The concentrate also exhibits a low level of volatile organics.Type: GrantFiled: October 7, 1994Date of Patent: January 1, 2002Assignee: Troy Technology Corporation, Inc.Inventors: Eeva-Liisa Kuusisto, Timothy Savage, Peter Schaeufele, Rudi Moerck
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Publication number: 20010055603Abstract: It is an object of the present invention to provide a water-soluble antibacterial polymer having an excellent antibacterial property and stability, and a liquid formulation comprising it for contact lenses, which is suitably used for disinfection or preservation of contact lenses.Type: ApplicationFiled: November 12, 1998Publication date: December 27, 2001Inventors: KAZUHIKO NAKADA, SADANORI OONO
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Publication number: 20010053801Abstract: Composition comprising an oil phase, an aqueous phase, at least one emulsifying agent of the water in oil (W/O) type, at least one emulsifying agent of the oil in water (O/W) type, in the form of an auto-inversible inverse latex comprising from 20% to 70% by weight, and preferably from 25% to 50% by weight, of a branched or reticulated polyelectrolyte, characterized in that said polyelectrolyte is either a homopolymer based on a monomer having a weakly acidic function, partially or totally salified, or a copolymer based on at least one monomer having a strongly acidic function, copolymerized either with at least one monomer having a strongly acidic function, or with at least one neutral monomer, and characterized in that the solvent constituting the oil phase is selected from white mineral oils, squalene or hydrogenated polyisobutene. Cosmetic, dermocosmetic, dermopharmaceutical or pharmaceutical composition including it.Type: ApplicationFiled: May 7, 2001Publication date: December 20, 2001Applicant: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPICInventors: Guy Tabacchi, Jean Pierre Boiteux, Chantal Amalric, Nelly Michel, Paul Mallo
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Publication number: 20010053794Abstract: A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.Type: ApplicationFiled: January 28, 2000Publication date: December 20, 2001Inventors: W. Harry Mandeville III, Thomas X. Neenan, Stephen Randall Holmes-Farley
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Patent number: 6331296Abstract: An assay comprises contacting cells containing a conformationally altered protein with test compound and determining if the altered protein is cleared. The cells may be scrapie-infected neuroblastoma cells. Another assay comprises contacting organ or tissue homogenate (at pH 5.0 or less) with test compound to determine if altered protein in the homogenate is cleared. The homogenate may be brain homogenate from a transgenic mouse infected with human prions. Compounds which are found to clear the altered protein are useful in preventing, arresting and/or reversing (i.e. treating) a disease associated with the conformationally altered protein.Type: GrantFiled: November 22, 1999Date of Patent: December 18, 2001Inventors: Stanley B. Prusiner, Surachai Supattapone, Michael R. Scott
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Patent number: 6326011Abstract: A copolymer having silyl groups with at least one reactive functional group bonded thereto. The copolymer comprises a monomer (A) shown by the following Formula (I): wherein R1 is hydrogen atom or methyl; R2 is alkylene group having 1-6 carbon atoms; and R3, R4 and R5 each is a reactive functional group which can cross-link molecules of the copolymer by hydrolyzing. Further, the copolymer preferably comprises, as a constituent monomer, an alkyl (meth)acrylate and a siloxane-containing (meth)acrylate. A coating-forming method comprises hydrolyzing the composition on a material to be treated to cross-link molecules of the copolymer when on the material. A coating of the cross-linked copolymer has resistance to washing. This coating can modify the nature of hair, improve make-up retention, and provide skin-protecting. It can impart water-repellency, resistance to fouling, suitability as a sizing and crease resistance to fibers.Type: GrantFiled: January 28, 1999Date of Patent: December 4, 2001Assignee: Shiseido Co., Ltd.Inventors: Kazuyuki Miyazawa, Toshio Yanaki, Fumiaki Matsuzaki
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Publication number: 20010046481Abstract: Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be either trapped in the gel and released by diffusion as the gel degrades, or they may be covalently bound through hydrolyzable carbamate linkages. Hydrolysis of these carbamate linkages releases the amine drug at a controllable rate as the gel degrades.Type: ApplicationFiled: April 21, 2001Publication date: November 29, 2001Applicant: Shearwater CorporationInventors: Michael David Bentley, Xuan Zhao
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Publication number: 20010041171Abstract: The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.Type: ApplicationFiled: June 11, 2001Publication date: November 15, 2001Applicant: GelTex Pharmaceuticals, Inc.Inventors: Caroline Isabelle Bacon Kurtz, Richard Fitzpatrick
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Publication number: 20010038831Abstract: A superporous hydrogel composite is formed by polymerizing one or more ethylenically-unsaturated monomers, and a multiolefinic crosslinking agent, in the presence of particles of a disintegrant and a blowing agent. The disintegrant, which rapidly absorbs water, serves to greatly increase the mechanical strength of the superporous hydrogel and significantly shorten the time required to absorb water and swell. Superporous hydrogel composites prepared by this method have an average pore size in the range of 10 &mgr;m to 3,000 &mgr;m. Preferred particles of disintegrant include natural and synthetic charged polymers, such as crosslinked sodium carboxymethylcellulose, crosslinked sodium starch glycolate, and crosslinked polyvinylpyrrolidone. The blowing agent is preferably a compound that releases gas bubbles upon acidification, such as NaHCO3. Improved hydrogel composites formed without a blowing agent are also provided.Type: ApplicationFiled: March 16, 2001Publication date: November 8, 2001Inventors: Kiham Park, Haesun Park
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Patent number: 6312668Abstract: Coatings for hard tissue and surfaces of the oral environment are provided that reduce adhesion of bacteria and proteinaceous substances to these surfaces. Methods of reducing adhesion of these materials to such surfaces, and polymers for incorporation into such coatings are also provided.Type: GrantFiled: January 27, 1999Date of Patent: November 6, 2001Assignee: 3M Innovative Properties CompanyInventors: Sumita B. Mitra, Charles E. Shelburne, Sharon M. Rozzi, Brant L. Kedrowski
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Patent number: 6299868Abstract: The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.Type: GrantFiled: July 14, 1999Date of Patent: October 9, 2001Assignee: GelTex Pharmaceuticals, Inc.Inventors: Thomas Jozefiak, Stephen Randall Holmes-Farley, W. Harry Mandeville, III, Chad Cori Huval, Venkata R. Garigapati, Keith K. Shackett, Danny Concagh
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Patent number: 6294180Abstract: A cosmetic or dermatological powder, which comprises (i) from 5 to 60% by weight, relative to the total weight of the powder, of at least one starch modified by pregelatinization, oxidation, crosslinking, esterification or a combination thereof, (ii) from 30 to 90% by weight, relative to the total weight of the powder, of an oily phase comprising at least one oil, and (iii) at least one electrolyte, wherein the oily phase/starch weight ratio is ≧1.Type: GrantFiled: November 8, 1999Date of Patent: September 25, 2001Assignee: L'OrealInventors: Gwenaeelle Demars, Sandrine Koely
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Patent number: 6290947Abstract: A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.Type: GrantFiled: June 19, 2000Date of Patent: September 18, 2001Assignee: GelTex Pharmaceuticals, Inc.Inventors: Richard Fitzpatrick, Chad Cori Huval, Caroline Isabelle Bacon Kurtz, W. Harry Mandeville, III, Thomas X. Neenan
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Publication number: 20010018047Abstract: The invention provides an aqueous soil treatment composition comprising water and,Type: ApplicationFiled: April 19, 2001Publication date: August 30, 2001Inventors: Simon Alexander Hanson Rose, Jayne Anne Turner
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Publication number: 20010014310Abstract: Aqueous dispersions of crystalline polymers based on hydrophobic monomers, preferably on a mixture of hydrophobic and hydrophilic monomers which contains a crosslinking monomer, particularly side chain crystalline (SCC) polymers. The dispersions are useful for providing coatings on substrates, particularly on seeds (whose dormancy is thus extended) and on fibrous substrates, particularly human hair (which thus becomes heat-settable).Type: ApplicationFiled: January 18, 2001Publication date: August 16, 2001Inventors: Ray F. Stewart, Natarajan Balachander, Steven P. Bitler, Loc Phan, Valentine Y. Yoon
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Publication number: 20010012509Abstract: Coatings for hard tissue and surfaces of the oral environment are provided that reduce adhesion of bacteria and proteinaceous substances to these surfaces. Methods of reducing adhesion of these materials to such surfaces, and polymers for incorporation into such coatings are also provided.Type: ApplicationFiled: January 27, 1999Publication date: August 9, 2001Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventors: SUMITA B. MITRA, CHARLES E. SHELBURNE, SHARON M. ROZZI, BRANT L. KEDROWSKI
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Patent number: 6270755Abstract: The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.Type: GrantFiled: April 3, 2000Date of Patent: August 7, 2001Assignee: GelTex Pharmaceuticals, Inc.Inventors: Caroline Isabelle Bacon Kurtz, Richard Fitzpatrick
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Patent number: 6267952Abstract: The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.Type: GrantFiled: October 5, 1998Date of Patent: July 31, 2001Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Molly Kate Boie, Venkata R. Garigapati
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Publication number: 20010008958Abstract: A polymeric resin is disclosed in the form of beads or particles having a coating thereon which renders the resin blood compatible. The resin comprises divinylbenzene monomer which has a porosity, pore size, and surface area suitable for absorbtion of unhealthy components of blood, such as &bgr;-2-microglobulin.Type: ApplicationFiled: December 22, 2000Publication date: July 19, 2001Inventors: Robert M. Strom, Daniel J. Murray
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Patent number: 6261538Abstract: Disclosed is a series of the water-insoluble polymeric quaternary phosphonium salt-type bactericides, which consists of as active bactericidal components an amino quaternary phosphonium salt, a quaternary ammonium group-containing quaternary phosphonium salt, an amino quaternary phosphonium salt-quaternay ammonium salt, or a quaternary ammonium salt-containing quaternary phosphonium salt and quaternary ammonium salt carried on a resin carrier which can be chloromethylated. Said bactericide series has rapid and highly effective bactericidal activity, and can be used repeatedly, and used widely for sterilizing and disinfecting various fluid media such as different industrial and domestic water and the like.Type: GrantFiled: October 28, 1998Date of Patent: July 17, 2001Assignees: China Petrochemical Corporation, Research Institute of Petroleum Processing, SINOPECInventors: Yongjun Chen, Xieqing Wang, Bengao Li
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Publication number: 20010006628Abstract: Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.Type: ApplicationFiled: January 5, 2001Publication date: July 5, 2001Inventors: Sharad K. Govil, Ludwig J. Weimann
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Publication number: 20010005504Abstract: In order to provide an adhesive to adhere to the tissue of organisms a buffered solution containing a protein macromer having a vinylated protein, a polysaccharide macromer having a vinylated polysaccharide, or the both by mixture, along with a photo-reactive compound which generates radicals by irradiation is prepared. The solution is cured into a gel state by irradiation, adheres to and is fixed on the tissue surface.Type: ApplicationFiled: December 8, 2000Publication date: June 28, 2001Inventors: Takehisa Matsuda, Yasuhide Nakayama, Nobumasa Tsutsui
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Patent number: 6251416Abstract: A clear, one-phase, efficacious aqueous microemulsion of an agriculturally active pyrethroid insecticide for delivery at a high loading of active is provided herein which is free of nonylphenol ethoxylate.Type: GrantFiled: April 4, 2000Date of Patent: June 26, 2001Assignee: ISP Investments Inc.Inventors: Kolazi S. Narayanan, Domingo Jon, Robert M. Ianniello, Donald Prettypaul
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Patent number: 6235277Abstract: Deodorant granulate for lining ashtrays for receiving tobacco ash, including an active component. The active component includes perfume which is one of aromatic and suitable for use on the human body, high viscosity solvent with low evaporation, and undecylenic acid deodorant. The active component is incorporated into non-inflammable mineral granulates whose granularity is selected so as not to leave any trace of dust when used, and has a porosity that enables the mineral granulate to absorb at least 15 wt % of the active component, and to release the active component upon contact with a lit cigarette or cigar. Method for lining ashtrays.Type: GrantFiled: May 13, 1998Date of Patent: May 22, 2001Inventor: Marcel Jean
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Patent number: 6228354Abstract: A water-resistant, film-forming topical antimicrobial composition, removable by high pH solution, made in accordance with the principles of the present invention includes a polyvinyl lactam, a broad spectrum antimicrobial agent, a copolymer of polyacrylate/polyoctylacrylamide, a pH sensitive acrylic polymer, and an alcohol. Preferably, the polyvinyl lactam is polyvinyl pyrrolidone. The preferred broad spectrum antimicrobial agent is iodine which is preferably complexed to the polyvinyl pyrrolidone. A process for making the film-forming topical antimicrobial composition is also provided.Type: GrantFiled: July 2, 1999Date of Patent: May 8, 2001Assignee: Allegiance CorporationInventor: David K. Jeng
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Publication number: 20010000728Abstract: An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.Type: ApplicationFiled: December 7, 2000Publication date: May 3, 2001Inventors: Amapreet S. Sawhney, Michelle D. Lyman, Peter K. Jarrett, Ronald S. Rudowsky
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Patent number: 6218166Abstract: Disclosed are compositions and methods for enhancing the antibody and T cell response to cellular antigens by incorporating an immunopotentiating agent into the cellular membrane or into an intracellular compartment. Such adjuvant-incorporated cell compositions are useful in methods to increase immune responses against antigens, including immunologically cryptic tumor cell antigens, and may be employed to generate useful diagnostic antibodies, to elicit anti-tumor effects in immunized animals, and to significantly prolong survival in animals with cancer.Type: GrantFiled: June 5, 1995Date of Patent: April 17, 2001Assignee: John Wayne Cancer InstituteInventors: Mepur H. Ravindranath, Donald L. Morton
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Patent number: 6193990Abstract: The present invention relates to novel dry-blended extrudable pesticidal resin composition, extruded pesticidal resin compositions and pelletized pesticidal resin compositions comprising, as the active ingredient, O,O-diethyl S-[[1,1-dimethylethyl)thio]-methyl]phosphorodithioate, O,O-diethyl S-(ethylthio-methyl)phosphorodithioate or a pesticidal chemical wherein said technical grade of said pesticidal chemical has a dermal and/or oral LD50, as measured on rats or rabbits of less than 50 mg/kg. The novel compositions of the present invention are characterized by markedly reduced mammalian toxicity and increased pesticide stability and are essentially free of dust. Further, the present invention also relates to a process for preparing the present safened pesticidal resin compositions.Type: GrantFiled: May 9, 1994Date of Patent: February 27, 2001Assignee: American Cyanamid Co.Inventor: Joseph Fredrick Cannelongo
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Patent number: 6191107Abstract: The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release preparation which comprises the complex of human growth hormone and zinc and a biodegradable polymer and which has a high entrapment ratio of human growth hormone and exhibits a stable sustained-release suppressing the initial burst.Type: GrantFiled: September 11, 1998Date of Patent: February 20, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Yutaka Yamagata, Masafumi Misaki, Susumu Iwasa
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Patent number: 6190688Abstract: A material with excellent selective absorption of super antigens. Said material contains urea bonds or thiourea bonds and remains active even in a high protein concentration solution in the neutral region, Activity remains after sterilization. Also provided is a body fluid purifying column for eliminating or detoxification of super antigens. In addition to that, this invention provides a wound dressing material with super antigen adsorbing properties.Type: GrantFiled: March 1, 1999Date of Patent: February 20, 2001Assignee: Toray Industries, Inc.Inventors: Mayumi Fukuyama, Keishi Miwa, Kazuo Ishikawa