Heterocyclic Monomer Patents (Class 424/78.32)
  • Patent number: 11744248
    Abstract: A composition and method for inducing and inflicting damage to cell membranes of microorganism by inducing changes in membrane permeability caused by polycation-induced membrane pores. The control of Clostridium difficile spores with an efficacy of 99.99% on hard surfaces is provided. The invention includes the application of an evaporation-induced self-assembly, surfactant-mediated synthesis or self-condensing polymer, which forms a film which is both flexible on the surface as a nano-polymeric coating and with refractive index yielding a transparent coating. The polymeric matrix includes various biocidal polymeric cationic quaternary salts, one being a silyl quaternary having a kinetic zeta potential to disrupt bacterial spores functions. The polymeric matrix consist of multiple small molecule biocides as well as polymerics biocide combinations not otherwise seen to develop an surface topography of peaks and troughs in the nano range to resist bacterial adhesion factors and subsequent biofilm formation.
    Type: Grant
    Filed: August 19, 2018
    Date of Patent: September 5, 2023
    Assignee: Enviro Specialty Chemicals Inc.
    Inventors: Bruce Smyth, Michael Bralkowski
  • Patent number: 10117859
    Abstract: Methods for preparing suspensions of active pharmaceutical ingredients for ensuing drug delivery. The suspension may include a mixture of a relatively low dosage API and a relatively high dosage API or a mixture of an API with a suitable excipient.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: November 6, 2018
    Assignee: SOUTHWEST RESEARCH INSTITUTE
    Inventors: Hong Dixon, Larry A. Cabell, Joseph A. McDonough
  • Patent number: 9034352
    Abstract: A synergistic microbicidal composition. The composition comprises a silver-containing copolymer comprising polymerized units of a monomer X and a monomer Y; wherein monomer X is an ethylenically unsaturated compound having a substituent group selected from an unsaturated or aromatic heterocyclic group having at least one hetero atom selected from N, O and S; wherein monomer Y is selected from carboxylic acids, carboxylic acid salts, carboxylic acid esters, organosulfuric acids, organosulfuric acid salts, sulfonic acids, sulfonic acid salts, phosphonic acids, phosphonic acid salts, vinyl esters, (meth)acrylamides, C8-C20 aromatic monomers containing at least one exocyclic ethylenic unsaturation and combinations thereof; and at least one organic biocide.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: May 19, 2015
    Assignee: Rohm and Haas Company
    Inventors: Li-Liang Shen Chia, Terry Michael Williams
  • Publication number: 20150044161
    Abstract: Described herein are multifunctional polymers comprising a first repeating unit having at least one pseudo-cationic moiety, a second repeating unit having at least a hydrophobic moiety, and a third repeating unit, where the weight-average molecular weight is less than about 10,000 Da. In one embodiment the polymers exhibit antimicrobial activity. Also provided are compositions formulated with the multifunctional polymers, and a method of providing antimicrobial activity.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 12, 2015
    Applicant: ISP Investments Inc.
    Inventors: Jui-Chang Chuang, Xuejun Liu, Osama M. Musa, Karen Winkowski
  • Publication number: 20150010604
    Abstract: [Problem] To provide: a bactericidal agent composition which can exhibit an excellent bactericidal effect in the presence of an organic substance and against biofilms; a method for producing the bactericidal agent composition; and a sterilization method using the bactericidal agent composition. [Solution] A bactericidal agent composition which comprises water containing ultrafine bubbles having a most frequent particle diameter of 500 nm or less and a bactericidal component. Preferably, the density of most frequent particles of the ultrafine bubbles are 10,000 particles or more and the density of ultrafine bubbles each having a particle diameter of 1000 nm or less is 1,000,000 particles or more.
    Type: Application
    Filed: February 22, 2013
    Publication date: January 8, 2015
    Applicants: SUNSTAR ENGINEERING INC., SUNSTAR INC., NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventors: Miwa Ishii, Toru Oka, Yoshimitsu Nakayama, Masumi Torii, Masaru Sugimori, Shogo Takashiba, Hiroshi Maeda, Fumi Mineshiba, Kimito Hirai
  • Publication number: 20140348779
    Abstract: A topical ophthalmic composition for treatment of dry eye is disclosed. In preferred embodiments, the composition comprises as active ingredients hyaluronic acid or a pharmaceutically acceptable salt thereof and polyvinylpyrrolidine. In other embodiments of the invention, the composition additionally comprises polyvinyl alcohol. Methods of preparation of the composition are disclosed, as well as methods for use of the composition in the treatment of dry eye.
    Type: Application
    Filed: January 7, 2013
    Publication date: November 27, 2014
    Inventors: Eyal Zolotariov, Zvi Zolotariov
  • Publication number: 20140322345
    Abstract: The present invention provides novel slow-releasing ophthalmic compositions containing Povidone Iodine (PVP-I) and uses thereof in the treatment of acute infections of at least one eye tissue from bacterial, mycobacterial, viral, fungal, or amoebic causes and for preventing such infections in appropriate clinical settings. Each of the ophthalmic compositions contains povidone iodine, osmotic pressure regulator, suspending agent and EDTA-Na, wherein povidone iodine exists as microsphere particles formed by PVP-I and sodium alginate.
    Type: Application
    Filed: November 28, 2012
    Publication date: October 30, 2014
    Inventors: Bo Liang, John J. Baldwin, Yong Lu
  • Publication number: 20140314705
    Abstract: The present specification generally relates to compositions comprising a thermoresponsive polymer and methods of treating a soft tissue condition using such compositions.
    Type: Application
    Filed: July 3, 2014
    Publication date: October 23, 2014
    Inventors: Scott Whitcup, Orest Olejnik
  • Publication number: 20140308236
    Abstract: The present invention provides a composition including an antibacterial polymer bound to a synthetic water soluble polymer, methods of using the composition for avoiding bacterial growth and processes of making plastic material which include these antibacterial compositions.
    Type: Application
    Filed: January 2, 2014
    Publication date: October 16, 2014
    Inventors: Havazelet BIANCO-PELED, Maya DAVIDOVICH-PINHAS
  • Publication number: 20140242024
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicant: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla, Timothy Sargeant, Joshua Stopek
  • Patent number: 8795647
    Abstract: The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: August 5, 2014
    Assignee: The Research Foundation for The State University of New York
    Inventors: Nicole Sampson, Kathlyn Parker, Airong Song
  • Publication number: 20140147472
    Abstract: Provided is a bioadhesive composition and device including same, the composition including a polymeric matrix and at least one synthetic bioadhesive polymer carried by the polymeric matrix, the polymeric matrix including at least one synthetic thermoplastic polymer characterized by one or more of (a) an average molecular weight in the range of between 20,000 Da to 90,000 Da; and (b) it includes polycaprolactone (PCL); wherein exposure to heat causes the bioadhesive composition to transform into a non-solid state and to cohesively adhere to a biological tissue upon subsequent cooling thereof. Also provided herein are methods of preparing the composition or device, and use of the composition or device in therapy, e.g. for treating hernia.
    Type: Application
    Filed: September 27, 2011
    Publication date: May 29, 2014
    Applicant: MEDIZN TECHNOLOGIES LTD.
    Inventors: Nissan Elimelech, Ana Dotan, Amos Ophir
  • Publication number: 20140147410
    Abstract: A synergistic microbicidal composition. The composition comprises: (a) silver ion; and (b) diiodomethyl-p-tolylsulfone; wherein a weight ratio of silver to diiodomethyl-p-tolylsulfone is from 1: 1/0.008 to 1/0.1, 1/0.13 to 1/8 or 1/120 to 1/280.
    Type: Application
    Filed: June 29, 2012
    Publication date: May 29, 2014
    Inventor: Rohm and Haas Company
  • Publication number: 20140140936
    Abstract: The present invention provides compositions which not only effectively kill a broad spectrum of microorganisms present on surfaces on contact but continue to kill microorganisms for a period of time thereafter.
    Type: Application
    Filed: January 24, 2014
    Publication date: May 22, 2014
    Applicant: Reckitt Benckiser LLC.
    Inventors: Timothy Michael Cusack, Karen McCue, Hubert W. Ulmer
  • Patent number: 8715635
    Abstract: A rotaxane consisting of a cucurbituril and an uncharged guest molecule, having low or null affinity therebetween is provided as well as processes for providing the same. Various uses as energy converters (“frictionless” molecular motors), biochips and biosensors using the same are also provided.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: May 6, 2014
    Assignee: Technion Research & Development Foundation Limited
    Inventor: Ehud Keinan
  • Patent number: 8715708
    Abstract: A novel class of Cylic Acetal biomaterials (CABs) based on a cyclic acetal unit is disclosed and claimed by Applicants. Two novel biomaterials suitable for use in a variety of biological applications including in the orthopedic field for joint and cartilage replacement and/or repair, and bone cement. The biomaterials are comprised of either a network of monomers of 5-ethyl-5-(hydroxymethyl)-?,?-dimethyl-1,3-dioxane-2-ethanol diacrylate (EHD) and a hydrogel comprised of EHD and poly(ethylene glycol) diacrylate (PEG-EHD).
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: May 6, 2014
    Assignee: University of Maryland
    Inventors: John Patrick Fisher, Sachiko Kaihara, Jennifer Lynn Moreau, Parth Modi
  • Publication number: 20140120146
    Abstract: A medical antimicrobial composition includes a siloxanyl structure-containing polymer and an ammonium group-containing polymer, which is excellent in transparency, flexibility and mechanical properties, and also excellent in adhesion to a base resin with good mechanical properties, particularly to a silicone resin. The medical antimicrobial composition includes an ammonium group-containing polymer compound (A) dispersed in a siloxanyl structure-containing polymer (B) and a medical device comprising the medical antimicrobial composition.
    Type: Application
    Filed: January 3, 2014
    Publication date: May 1, 2014
    Applicant: Toray Industries, Inc.
    Inventors: Masataka Nakamura, Kazuhiko Fujisawa, Tsutomu Goshima
  • Publication number: 20140072526
    Abstract: The present invention relates to an adsorbate of a pharmaceutically compatible rasagiline salt comprising at least one pharmaceutically compatible adjuvant, wherein the at least one pharmaceutically compatible adjuvant is a water-soluble, organic solvent and the rasagiline salt is present in the adsorbate as an amorphous substance.
    Type: Application
    Filed: September 3, 2013
    Publication date: March 13, 2014
    Applicant: RATIOPHARM GMBH
    Inventors: Alexander Lehmann, Frank Muskulus, Julia Schulze-Nahrup
  • Patent number: 8647666
    Abstract: The invention provides a method of ameliorating systemic inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene divinyl benzene copolymer and a polyvinyl pyrrolidone polymer. More particularly, the method relates to using these polymers as an enteral sorbent preparation to remove inflammatory mediators, such as cytokines, from the intestinal lumen. The polymers can be in the form of a preparation of polystyrene divinyl benzene copolymer beads with a biocompatible polyvinyl pyrrolidone polymer coating.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: February 11, 2014
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: John A. Kellum, Mitchell P. Fink
  • Patent number: 8647614
    Abstract: A method for reducing the occurrence of new post-operative fractures in vertebrae of a patient's spine after a vertebroplasty procedure performed to stabilize a fracture in a vertebra of a patient comprising the steps of performing a vertebroplasty procedure to stabilize a fracture in a vertebra of the patient, wherein the vertebroplasty procedure comprises the step of injecting a material into the fractured vertebra, wherein the material is formed by mixing together a first paste and a second paste, wherein the first paste comprises at least one of a polymerizable monomer and a filler, and wherein the second paste comprises at least one of a polymerizable monomer and a filler.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: February 11, 2014
    Assignee: Orthovita, Inc.
    Inventors: Theodore D. Clineff, Maarten Persenaire, Gina M. Nagvajara, Marissa M. Darmoc, Matthew B. Havener, Stephen G. Gilbert, Erik M. Erbe
  • Publication number: 20140017309
    Abstract: The invention provides a method of ameliorating inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene divinyl benzene copolymer and a polyvinyl pyrrolidone polymer. More particularly, the method relates to using these polymers as an enteral sorbent preparation to remove inflammatory mediators, such as cytokines, from the intestinal lumen. The polymers can be in the form of a preparation of polystyrene divinyl benzene copolymer beads with a biocompatible polyvinyl pyrrolidone polymer coating.
    Type: Application
    Filed: September 12, 2013
    Publication date: January 16, 2014
    Applicant: University of Pittsburgh-Of the Commonwealth System of Higher Education
    Inventors: John A. Kellum, Mitchell P. Fink
  • Publication number: 20130344159
    Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (1) wherein: K represents O—Z or NH—Z, Z representing (CR2R3)m-CH3, (CH2—CH2—O)m-H, (CH2—CH2—O)m-CH3, (CH2)m-NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; i and j represent independently an integer chosen between 0 and 2; X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.
    Type: Application
    Filed: March 9, 2012
    Publication date: December 26, 2013
    Applicants: OCCLUGEL, UNIVERSITE PARIS DIDEROT - PARIS 7, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Laurence Moine, Alexandre Laurent, Michel Wassef, Laurent Bedouet, Stephanie Louguet, Valentin Verret, Emeline Servais
  • Publication number: 20130337033
    Abstract: The invention relates to nitric oxide-releasing compositions comprising polyacrylonitrile polymers that are diazeniumdiolated, and to medical devices comprising such compositions, as well as to methods of making and using the compositions and medical devices.
    Type: Application
    Filed: June 14, 2013
    Publication date: December 19, 2013
    Inventors: Kenneth J. Balkus, JR., Wenjin Deng, Alysia Lowe, Dennis W. Smith, JR.
  • Publication number: 20130331869
    Abstract: A novel electrically conductive polymer composite composed of polycaprolactone fumarate-polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and Dorsal Root Ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in pre-formed scaffolds of PCLF resulting in an interpenetrating network of PCLF-PPy. PCLF-PPy composite materials possess electrical conductivity up to 6 mS cm?1 with compositions ranging from 5-13.5 percent polypyrrole of the bulk material. Surface topographies of PCLF-PPy materials show microstructures with a RMS roughness of 1195 nm and nanostructures with RMS roughness of 8 nm. PCLF-PPy derivatives were synthesized with anionic dopants to determine effects on electrical conductivity and to optimize the chemical composition for biocompatibility.
    Type: Application
    Filed: October 15, 2010
    Publication date: December 12, 2013
    Inventors: M. Brett Runge, Mahrokh Dadsetan, Michael J. Yaszemski
  • Publication number: 20130295041
    Abstract: An oral care compositon is described for use in the treatment or alleviation of the symptoms of dry mouth comprising polyvinyl pyrrolidone (PVP) or a derivative thereof, an anionic mucoadhesive polymer and an orally acceptable carrier or excipient.
    Type: Application
    Filed: July 1, 2013
    Publication date: November 7, 2013
    Inventors: Gertrud KAWA, Shireen Uppal, David Urquhart
  • Patent number: 8491880
    Abstract: A camptothecin/polymer dual phase drug release system is described that is stable in both liquid and lyophilized states. The polymer contains acetals and/or ketals.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: July 23, 2013
    Assignee: Mersana Therapeutics, Inc.
    Inventors: James Rolke, Russell C. Petter, Mao Yin, Aleksandr Yurkovetskiy, Gui Liu, Emile Farhan
  • Publication number: 20130183263
    Abstract: Pharmaceutical compositions and kits including a tyrosine hydroxylase inhibitor; melanin, a melanin promoter, or a combination thereof; a p450 3A4 promoter; and a leucine aminopeptidase inhibitor are provided. Also provided are methods of treating cancer in a subject, comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3A4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof. Also provided are methods of reducing cell proliferation in a subject comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3A4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof.
    Type: Application
    Filed: January 16, 2013
    Publication date: July 18, 2013
    Inventor: STEVEN HOFFMAN
  • Patent number: 8475782
    Abstract: The present invention relates to a method for treating at least a surface of a substrate containing labile hydrogen atoms to confer to it cytotoxic properties or cell-adhesion properties, characterized in that it comprises at least a step consisting of exposing, within a liquid medium, said substrate or a surface thereof with at least a copolymer, said copolymer containing at least a monomer unit of type A including at least a reactive site able to attach to said substrate or said surface by covalent bonds and at least a monomer unit of type B including at least one molecule able to confer antimicrobial, antiviricidal and/or antifungicidal or cell-adhesion properties to said substrate or said surface, said step being carried out in efficient conditions to promote the covalent grafting of said copolymer to said substrate or a surface thereof.
    Type: Grant
    Filed: March 29, 2006
    Date of Patent: July 2, 2013
    Assignees: Institut Curie, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie (Paris IV)
    Inventors: Othman Bouloussa, Vincent Semetey, Francis Rondelez
  • Patent number: 8445611
    Abstract: The invention generally relates to novel polymers (SMAMPs) and their syntheses and use. The polymers exhibit promising properties of AMPs. In particularly, for example, a ring-opening metathesis polymerization (ROMP) platform was developed that allows syntheses of SMAMPs that employ a minimum number of norbornene-based building blocks and/or enable easy and independent variation of hydrophobic and hydrophilic groups in the monomer units and/or along the polymeric backbone to finetune and select desirable properties of the polymers.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: May 21, 2013
    Assignee: University of Massachusetts
    Inventors: Gregory N. Tew, Ahmad E. Madkour, Karen Lienkamp, Ashlan Marie Musante
  • Publication number: 20130108576
    Abstract: Abstract: Provided are methods of improving the stability of antiseptic compositions that include elemental iodine and certain hydroxycarboxylic acids, as well as stable, ready to use antiseptic compositions suitable for use in the nose and anterior nares.
    Type: Application
    Filed: June 29, 2010
    Publication date: May 2, 2013
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Matthew T. Scholz, Kevin D. Landgrebe, Katie F. Wlaschin
  • Publication number: 20130108575
    Abstract: This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.
    Type: Application
    Filed: October 16, 2012
    Publication date: May 2, 2013
    Applicant: C3 JIAN, INC.
    Inventor: C3 Jian, Inc.
  • Publication number: 20130101547
    Abstract: The present specification generally relates to compositions comprising a thermoresponsive polymer and methods of treating a soft tissue condition using such compositions.
    Type: Application
    Filed: October 16, 2012
    Publication date: April 25, 2013
    Applicant: ALLERGAN, INC.
    Inventor: Allergan, Inc.
  • Publication number: 20130101526
    Abstract: The present invention provides compositions which not only effectively kill a broad spectrum of microorganisms present on surfaces on contact but continue to kill microorganisms for a period of time thereafter.
    Type: Application
    Filed: December 10, 2012
    Publication date: April 25, 2013
    Applicant: RECKITT BENCKISER LLC.
    Inventor: Reckitt Benckiser LLC.
  • Publication number: 20130064873
    Abstract: An object of the present invention is to provide a nucleated tablet for contact lens (CL) cleaning that makes it possible to disinfect a CL simply and easily in the presence of a foaming component; a CL cleaning preparation that contains the nucleated tablet; and a method for cleaning a CL. The nucleated tablet for CL cleaning of the invention is a nucleated tablet including an outer shell that contains iodine-based bactericide, a carbonate, an organic acid, and a surfactant having, per partial weight of 2000 out of the molecular weight thereof, less than one hydroxyl group, and an inner nucleus that contains a neutralizing agent, a carbonate, an organic acid, and a surfactant, wherein the inner nucleus is coated for extended release.
    Type: Application
    Filed: January 14, 2011
    Publication date: March 14, 2013
    Applicant: OPHTECS CORPORATION
    Inventors: Kazuhiro Sasanuma, Kazuhiro Tone
  • Publication number: 20130039881
    Abstract: The present invention relates to the use of a combination of glycine, proline, and optionally a natural or synthetic film-forming polymer, and/or lysine and/or leucine, to prepare a composition for the treatment of mucositis induced by radiation or chemotherapy.
    Type: Application
    Filed: November 25, 2010
    Publication date: February 14, 2013
    Applicant: PROFESSIONAL DIETETICS S.R.L
    Inventors: Francesco Saverio Dioguardi, Edoardo Carlo Maria Conti, Giovanni Federico Maria Conti, Isabella Arborio Mella
  • Publication number: 20130004453
    Abstract: Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins Band C (SP-B and SP-C), two helical and amphiphilic proteins that are clitical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restlicted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-R mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, arc prepared by ling-opening polymelization of 13-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B.
    Type: Application
    Filed: March 17, 2011
    Publication date: January 3, 2013
    Inventors: Samuel H. Gellman, Shannon S. Stahl, Brendan P. Mowery, Annelise Barron, Michelle Dohm
  • Patent number: 8343473
    Abstract: A bactericidal or antimicrobial polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal or antimicrobial in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal or antimicrobial polymers, methods for rendering materials bactericidal or antimicrobial, and methods for using bactericidal or antimicrobial compositions to kill or reduce bacterial or microbial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; fibers; paper; and/or wound dressing.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: January 1, 2013
    Assignee: Purdue Research Foundation
    Inventors: Jeffrey P. Youngblood, Philippe H. Sellenet, Thomas R. Stratton
  • Publication number: 20120288469
    Abstract: A solid material adapted to kill bacteria in planktonic, spore and biofilm states is lethal toward a wide spectrum of gram positive and gram negative bacteria as well as other microbes. The solid material includes a significant amount of one or more surfactants entrained in a crosslinked polymeric network.
    Type: Application
    Filed: May 10, 2012
    Publication date: November 15, 2012
    Inventor: Matthew F. MYNTTI
  • Publication number: 20120263670
    Abstract: The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.
    Type: Application
    Filed: June 29, 2011
    Publication date: October 18, 2012
    Applicant: Ardelyx, Inc.
    Inventors: Dominique Charmot, Jeffrey W. Jacobs, Michael Robert Leadbetter, Marc Navre, Christopher Carreras, Noah Bell
  • Publication number: 20120213832
    Abstract: A dental curable composition comprises (A) a polymerizable monomer and (B) an organic amine-based polymerization initiator, wherein (A?) a long-chain polymerizable monomer having a chain length of 17 or more atoms is contained in the component (A) and/or (C) a soft resin material are/is contained in the composition, and when the amount (parts by weight) based on 100 parts by weight of the component (A) of the component (A?) is represented by [a?] and the amounts (parts by weight) based on 100 parts by weight of the total of the components (A) and (B) of the components (A), (B) and (C) are represented by (a), (b) and (c), respectively, 70?(a)?99.99, 0.01?(b)?5 30, 1?[a?]/5+(c)/1, 0?[a?]?95, and 0?(c)?250.
    Type: Application
    Filed: October 22, 2010
    Publication date: August 23, 2012
    Inventors: Tatsuya Ori, Haruka Nishitani, Sayuri Iwasaki, Yuya Yamamoto, Chidzuru Nishimoto
  • Patent number: 8173765
    Abstract: A polymer having a number average molecular weight (Mn) of about 10 000 g/mol comprising a monomeric rigid moiety R and a monomeric flexible moiety F, wherein R comprises a main-chain polycyclic core and F has a main chain comprising a number of atoms sufficient for the transition temperature of the polymer to be lower than the degradation temperature of the polymer is provided. A method of manufacturing of same is also provided. Biomedical devices, scaffolds and supports for tissue engineering, delivery devices, textiles, moulds, vehicle parts, tubes, active disassembly devices, microactuators, toys and inflatable membranes comprising same are also described.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: May 8, 2012
    Assignee: Valorisation-Recherche, Limited Partnership
    Inventors: Xiao-Xia Zhu, Julien Gautrot, Jie Zhang, Yu Shao
  • Patent number: 8153739
    Abstract: The invention generally relates to novel polymers (SMAMPs) and their syntheses and use. The polymers exhibit promising properties of AMPs. In particularly, for example, a ring-opening metathesis polymerization (ROMP) platform was developed that allows syntheses of SMAMPs that employ a minimum number of norbornene-based building blocks and/or enable easy and independent variation of hydrophobic and hydrophilic groups in the monomer units and/or along the polymeric backbone to finetune and select desirable properties of the polymers.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: April 10, 2012
    Assignee: University of Massachusetts
    Inventors: Gregory Tew, Ahmad E. Madkour, Karen Lienkamp, Ashlan Marie Musante
  • Patent number: 8148484
    Abstract: Norbornene-based biocidal polymers having primary, secondary or tertiary amine or phosphine end groups, the parent monomers, processes for preparing the monomers and polymers, and their use.
    Type: Grant
    Filed: October 16, 2006
    Date of Patent: April 3, 2012
    Assignee: KE Kelit Kunststoffwerk GesmbH
    Inventors: Xaver Norbert Gstrein, Wolfgang Kern, Karl Rametsteiner, Gerhard Seyfriedsberger, Franz Stelzer
  • Publication number: 20120076750
    Abstract: The present invention provides a non-liquid biomaterial that may be used as a surgical sealant, a suture support, a blood flow controller, an adhesion reducing agent, an adhesion preventing agent, a tissue support, a tissue filler, a wound dressing or a combination thereof. The non-liquid biomaterial may comprise a blood derived material such as plasma, platelet poor plasma, platelet rich plasma or a material derived from blood containing tissue aspirate, such as bone marrow aspirate, a protein binding agent and a polymerizing agent. Methods for making and using the non-liquid biomaterial are also provided.
    Type: Application
    Filed: December 7, 2011
    Publication date: March 29, 2012
    Inventors: Hillary Enyart, Jacy Hoeppner, Mike Leach, Shon Steger, Sona Sundaramurthy
  • Publication number: 20120027698
    Abstract: Disclosed herein is a cosmetic and/or pharmaceutical composition comprising, in a physiologically acceptable medium, at least one (co)polymer comprising a polymer backbone and at least one junction group linked to the polymer backbone and capable of establishing H bonds with at least one partner junction group, each pairing of a junction group involving at least 3H bonds, wherein the at least one (co)polymer comprises at least one ionizable group. Also disclosed herein is a cosmetic treatment process comprising applying the composition to keratin materials.
    Type: Application
    Filed: July 9, 2010
    Publication date: February 2, 2012
    Inventors: Nathalie Mougin, Sandrine Chodorowski-kimmes, Xavier Schultze
  • Publication number: 20120027716
    Abstract: The invention includes a preserved ophthalmic preparation comprising povidone-iodine (PVP-I) at a concentration sufficient to preserve the ophthalmic preparation, and at least one member selected from the group consisting of a steroidal anti-inflammatory compound, a non-steroidal anti-inflammatory compound, an antibacterial compound, an anti-allergy compound, and an anti-glaucoma compound. The invention also includes adding PVP-I to an ophthalmic composition in order to preserve the composition, wherein the PVP-I is added at a concentration sufficient to preserve the composition.
    Type: Application
    Filed: June 10, 2009
    Publication date: February 2, 2012
    Applicant: Foresight Biotherapeutics, Inc.
    Inventors: Jason Stein, Bo Liang, C. Michael Samson, Joseph A. Capriotti, Michael Weiser, Mark B. Abelson
  • Publication number: 20110301525
    Abstract: This invention relates to biomaterial compositions, methods and kits for producing hydrogels with tunable physico-chemical properties. Specifically, the invention relates to producing cellulosic hydrogels having optimized physico-chemical properties enabling support of cell growth or as replacement or filler for tissue repair, reconstruction or augmentation.
    Type: Application
    Filed: November 12, 2009
    Publication date: December 8, 2011
    Inventors: Steven B. Nicoll, Simone S. Stalling, Anna T. Reza
  • Publication number: 20110212172
    Abstract: The invention provides a method of ameliorating systemic inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene divinyl benzene copolymer and a polyvinyl pyrrolidone polymer. More particularly, the method relates to using these polymers as an enteral sorbent preparation to remove inflammatory mediators, such as cytokines, from the intestinal lumen. The polymers can be in the form of a preparation of polystyrene divinyl benzene copolymer beads with a biocompatible polyvinyl pyrrolidone polymer coating.
    Type: Application
    Filed: October 2, 2009
    Publication date: September 1, 2011
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: John A. Kellum, Mitchell P. Fink
  • Publication number: 20110195042
    Abstract: The present disclosure describes methods for enhancing an overall cooling sensation of an oral mucosa comprising administering a liquid composition comprising a thickening agent and/or a mucoadhesive polymer, a non-menthol coolant; and contacting the oral mucosa with the liquid composition. The disclosure also describes the liquid compositions.
    Type: Application
    Filed: February 7, 2011
    Publication date: August 11, 2011
    Inventors: Thomas Edward Huetter, Tracy L. Grosick
  • Publication number: 20110189120
    Abstract: The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
    Type: Application
    Filed: July 7, 2008
    Publication date: August 4, 2011
    Applicant: USA DHHS- NIH
    Inventors: Eric Calvo, Osvaldo Marinotti, Jose M.C. Ribeiro, Ivo M. Francischetti