Polymer From Ethylenic Monomers Only Patents (Class 424/78.31)
  • Patent number: 10537548
    Abstract: The present invention discloses a composition and its pharmaceutical composition for reducing body weight and body fat, and a use of said product The composition comprises epigallocatechin gallate, curcumin, and an excipient, wherein the excipient comprises at least one of glyceryl dibehenate, polyoxyethylene stearates, polysorbate 80 mixture, vitamin E polyethylene glycol succinate, glyceryl monostearate, and oleoyl polyoxyl-6 glycerides, or a combination thereof; the polysorbate 80 mixture comprises polysorbate 80 and magnesium aluminometasilicate. In animal testing where obesity is induced either prior to or during testing, use of the composition of the present invention leads to a significant reduction of body weight and body fat.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: January 21, 2020
    Assignee: CALIWAY BIOPHARMACEUTICALS CO., LTD.
    Inventor: Yu-Fang Ling
  • Patent number: 10428184
    Abstract: The invention concerns a method for producing a superhydrophobic membrane or surface coating of a substrate from an aqueous phase comprising the following steps: a) Preparing an aqueous dispersion by dispersing particles of hydrophobic polymer(s) in an aqueous solution of protic polymer(s), wherein the protic polymer(s) and the hydrophobic polymer(s) are present in a weight ratio of protic polymer(s):hydrophobic polymer(s) in a range of 5:95 to 22:78, b) electrospinning the dispersion of step a) onto a carrier for producing the membrane or onto the surface for producing the surface coating thereby producing at least one fiber and a nonwoven fabric from the fiber, c) subjecting the nonwoven fabric to a sol-gel process, wherein a precursor/precursors of the sol-gel comprise(s) an alkoxysilane, and d) curing the nonwoven fabric obtained by step c) at a temperature in a range of 50° C. to 150° C.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: October 1, 2019
    Assignee: Universitaet Bayreuth
    Inventors: Andreas Greiner, Seema Agarwal, Mitsunobu Doimoto
  • Patent number: 10426761
    Abstract: A method for treating a disease or for treating a symptom of a disease, or a combination of both, the disease being caused or aggravated by microorganisms includes: treating the disease, treating the symptom of the disease, or reducing the duration of the disease, or a combination of both by administering a barrier-forming composition in a therapeutically effective amount to a surface, the surface comprising a mammal mucosa, the mammal being infected with the disease or experiencing symptoms of the disease caused or aggravated by the microorganisms. The barrier-forming composition includes an antimicrobial. Upon administering the composition, the method includes forming a barrier coating on the surface that is active to kill or neutralize microorganisms encountered by the barrier coating. A composition with an agent active for relieving symptoms of a disease is also included.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: October 1, 2019
    Assignee: ARMS Pharmaceutical, LLC
    Inventors: Afif Mahmoud Ghannoum, Brian Vincent Sokol
  • Patent number: 10387694
    Abstract: Systems, methods, and electronic circuits facilitating embedded sensor chips in polymer-based coatings are provided. In one example, a method comprises fabricating an electronic circuit, the electronic circuit comprising one or more semiconductor devices, one or more sensors, and a communication element; encapsulating the electronic circuit within an insulator, resulting in an encapsulated circuit; and dispersing the encapsulated circuit into a lacquer solution comprising a polymer carrier and a solvent.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: August 20, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Ali Afzali-Ardakani, Homa Alemzadeh, Maryam Ashoori, Bahman Hekmatshoartabari, Elham Khabiri
  • Patent number: 9925311
    Abstract: Described is a kit for producing a crosslinked gel for surrounding urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, comprising a composition (A) comprising one or several cationically crosslinkable polymer(s), and a composition (B) comprising one or several crosslinking agent(s) for crosslinking the cationically crosslinkable polymer(s), wherein composition (A) and/or composition (B) additionally comprise(s) magnetizable particles or the kit additionally comprises a composition (C) that contains magnetizable particles. Upon contact of composition (A) with composition (B) in a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, a crosslinked gel is formed that partly or fully surrounds the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, and that contains the magnetizable particles.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: March 27, 2018
    Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
    Inventors: Ingo Grunwald, Katharina Richter, Arkadiusz Miernik, Martin Schoenthaler
  • Patent number: 9884922
    Abstract: Provided are hypromellose acetate succinate (HPMCAS) which exhibits high solubility and can suppress generation of undissolved materials when dissolved in a solvent; an HPMCAS-containing composition; and a method for producing the HPMCAS. More specifically, provided are HPMCAS having a ratio of 2-position MS to 3-position MS of 1.2 or less, wherein the 2-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 2-position carbon of each glucose unit of the HPMCAS has been directly replaced, and the 3-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 3-position carbon of each glucose unit of the HPMCAS has been directly replaced; a composition comprising the HPMCAS and a solvent; and the method for producing the HPMCAS.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: February 6, 2018
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Kazuki Kikuchi, Mitsuhiro Yoshida, Junichi Matsubara, Tatsuya Yamashita, Akira Kitamura, Naosuke Maruyama
  • Patent number: 9862992
    Abstract: A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of said substance or analyte or after said substance or analyte has been immobilized on said surface. The non-specific adsorption of impurity protein or the like which is co-existent in sample for assay is significantly restrained.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: January 9, 2018
    Assignee: JSR CORPORATION
    Inventors: Yukio Nagasaki, Tadahito Takahashi, Kazunori Kataoka, Fumiko Aboshi, Miki Kato, Tomoko Jomura, Hiroshi Kobayashi, Yoshinori Katsuyama, Masami Nakamae
  • Patent number: 9790335
    Abstract: Provided are modified bio-derived polymers having improved processability as well as methods of producing such polymers and articles produced therefrom. The modified bio-derived polymers have improved melt strength compared with presently available bio-derived polymers. Thus, the inventive bio-derived polymers are suitable for use in plastic processing techniques such as blow molding and blown film extrusion.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: October 17, 2017
    Assignee: Pennsylvania College of Technology
    Inventors: John R. Bartolomucci, Song Cheng
  • Patent number: 9782488
    Abstract: The invention provides water-soluble oligomer-beta blocker drug conjugates. A drug conjugate of the invention can be administered by any of a number of administration routes and exhibits properties that are different from the corresponding beta blocker not attached to the water-soluble oligomer.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: October 10, 2017
    Assignee: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Franco J. Duarte
  • Patent number: 9603919
    Abstract: The present invention provides a vaccine composition for transnasal mucous membrane administration, which contains an influenza virus antigen, polyriboinosinic polyribocytidylic acid (poly (I:C)) or a derivative thereof and a carboxyvinyl polymer. The present invention also provides a prophylactic method of influenza, including a step of administering the vaccine composition at least once to the nasal mucosa of a subject in need thereof.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: March 28, 2017
    Assignees: JAPAN AS REPRESENTED BY THE DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES, THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY, TOKO YAKUHIN KOGYO KABUSHIKI KAISHA
    Inventors: Hideki Hasegawa, Sadao Manabe, Takeshi Tanimoto, Takashi Miyazaki, Taizou Kamishita
  • Patent number: 9475891
    Abstract: A novel process of manufacturing colesevelam hydrochloride including the steps of alkylating polyallylamine with n-decylbromide and 6-bromohexyl trimethyl ammonium bromide, followed by cross-linking the alkylated polyallylamine with epichlorohydrin in an aqueous medium, and adding a suitable chloride ion source to obtain colesevelam hydrochloride.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: October 25, 2016
    Assignee: Navinta, LLC
    Inventor: Mahendra R. Patel
  • Patent number: 9132187
    Abstract: The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment of sub-clinical PCV2 infection in animals, preferably in pigs.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: September 15, 2015
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Vicky Fachinger, Knut Elbers, Marion Kixmoeller, Francois-Xavier Orveillon, Isabelle Freiin Von Richthofen, Axel Lischewski
  • Publication number: 20150147373
    Abstract: In an antifungal protective film having at least one layer and an acidifying polymer and a disulfite the at least one film layer includes fluid-filled bubbles or cells that are created by foaming. The cells created by foaming during the extrusion enable the generated sulfur dioxide to collect inside this film layer, thereby being buffered and achieving a long-term action releasing the antifungal sulfur dioxide. The film can have a single foamed layer containing the polymer and disulfite or such a layer sandwiched between two outer layers having different properties, all produced by coextrusion.
    Type: Application
    Filed: October 28, 2014
    Publication date: May 28, 2015
    Inventors: Michael KOHLA, Dana SIEWERT, Matthias PERICK
  • Publication number: 20150147288
    Abstract: The invention generally relates to environmental friendly pesticide compounds, formulations, methods of preparation and application and utilities thereof. More particularly, the invention relates to pesticide compounds and formulations that include terpenes or terpenoids having chemical formula of (C5H8)n, and its derivatives and analogs thereof, as active insecticidal ingredients; certain botanical essential oils as synergists, and other select ingredients as additives.
    Type: Application
    Filed: February 2, 2015
    Publication date: May 28, 2015
    Inventor: Tao Zhong
  • Patent number: 9040033
    Abstract: Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility active agent and such polymers, the polymers provide increased aqueous concentrations and/or improved physical stability of the active agent.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: May 26, 2015
    Inventors: Warren K. Miller, David K. Lyon, Dwayne T. Friesen, William B. Caldwell, David T. Vodak, Daniel E. Dobry
  • Publication number: 20150139934
    Abstract: A method for screening a patient for angioinhibition resistance and treating said patient having a disease susceptible to treatment via an anti-angiogenic agent. The screening method includes an assay for identifying the presence of angioinhibition resistance in patients by collecting patient blood or serum and subjecting it to a Chick Chorioallantoic Membrane (CAM) angiogenesis assay configured for accepting a human tumor wherein the human tumor xenograft includes a vasculature system. The screening method and assay further includes steps that include using the CAM results for identifying the endogenous pro-angiogenic non-peptide hormone concentrations of the blood sample by calculating the vascular activity of the vasculature system of the human tumor xenograft in the presence of anti-angiogenic drugs and inducing in the patient, a state of subclinical hypothyroidism prior to commencing anti-angiogenic treatment.
    Type: Application
    Filed: November 18, 2014
    Publication date: May 21, 2015
    Inventors: SHAKER A. MOUSA, PAUL J. DAVIS
  • Publication number: 20150132250
    Abstract: The invention features extracorporeal methods for the treatment of a subject having a pregnancy related hypertensive disorder, such as pre-eclampsia or eclampsia. The invention also features devices used for the extracorporeal treatment of subjects have a pregnancy related hypertensive disorder, such as pre-eclampsia or eclampsia.
    Type: Application
    Filed: January 20, 2015
    Publication date: May 14, 2015
    Inventor: S. Ananth KARUMANCHI
  • Publication number: 20150125505
    Abstract: Compositions, implantation devices and methods for stimulating an immune response to infection are discussed. In some examples, the compositions, implantation devices or methods of regulating the amplification of an adaptive immune response to infection involves use of one or more particles locally at a surgical or implant site to control bacterial infections without detrimental systemic side-effects. In some examples, the particles can be coated or layered onto the surface of an implantable device or material. In other examples, the particles can be injected into the site of implantation.
    Type: Application
    Filed: September 26, 2012
    Publication date: May 7, 2015
    Applicant: BioSpheres, Inc.
    Inventors: William Wustenberg, Michael Finch, Cyrus B. Munshi
  • Publication number: 20150118180
    Abstract: Formulations containing reactive oxygen species (ROS), processes for making these formulations, and methods of using these formulations are described. The formulations can include gels or hydrogels that contain at least one reactive oxygen species (ROS). The formulations can include a composition containing a reduced species (RS) and a reactive oxygen species (ROS). The formulations can also contain a rheology modifier and can include gels or hydrogels. Methods of preparing the formulations can include preparing a composition. Compositions can be prepared by providing water, purifying the water to produce ultra-pure water, combining sodium chloride to the ultra-pure water to create salinated water, and electrolyzing the salinated water at a temperature between about 4.5 to about 5.8° C.
    Type: Application
    Filed: October 24, 2014
    Publication date: April 30, 2015
    Applicant: REOXCYN DISCOVERIES GROUP, INC.
    Inventor: Andres Hoover
  • Publication number: 20150118274
    Abstract: A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent is provided. A method of making a composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent, said method comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent, is also provided. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising stimulating collagen beneath the skin defect is further provided.
    Type: Application
    Filed: January 9, 2015
    Publication date: April 30, 2015
    Inventor: Ayman BOUTROS
  • Patent number: 9011830
    Abstract: The present invention relates to a protective agent suitable to protect the human skin against toxic materials, particularly against chemicals with nucleophilic sites. The active moiety is a polyanhydride derivative. The active transdermal retardant offers a barrier property and chemically and/or physically reacts with harmful chemicals to decrease percutaneous absorption. In the preferred embodiments, polyanhydride in its low molecular weight form reduced flux of nicotine and nitrofurazone significantly. Additionally, polyanhydride in its high molecular weight form prevented nicotine absorption and decreased nitrofurazone permeation dramatically. Moreover, the polyanhydride in its high molecular weight form reduced nitroglycerin flux to a lesser extent.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: April 21, 2015
    Inventors: Mohammad Erfan, Hamid Reza Moghimi, Azadeh Haeri, Tahereh Sadat Jafarzadeh Kashi, Farhad Jafarzade
  • Patent number: 9011831
    Abstract: A polymer of hydrophobic monomers and hydrophilic monomers is provided. It is also provided a polymer blend that contains the polymer and another biocompatible polymer. The polymer or polymer blend and optionally a biobeneficial material and/or a bioactive agent can form a coating on an implantable device such as a drug delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: April 21, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Ni Ding
  • Publication number: 20150079021
    Abstract: A method of treating a skin or scalp disorder is disclosed. The method calls for topically (a) administering to a subject in need thereof a therapeutically effective amount of a composition has at least one oligomeric or polymeric form of a monoterpene, and is substantially devoid of the corresponding monomeric form of said monoterpene, and (b) treating a skin or scalp disorder. The monoterpene is selected from the group consisting of alloocimene, limonene, ?-pinene, ?-pinene, geranyl acetate, ?-phellandrene, ?-terpinene, 3-carene and 2-carene, and a pharmaceutically acceptable carrier; and wherein the composition is substantially devoid of the corresponding monomeric form of said monoterpene.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 19, 2015
    Inventor: Zadik Hazan
  • Patent number: 8969322
    Abstract: The invention features extracorporeal methods for the treatment of a subject having a pregnancy related hypertensive disorder, such as pre-eclampsia or eclampsia. The invention also features devices used for the extracorporeal treatment of subjects have a pregnancy related hypertensive disorder, such as pre-eclampsia or eclampsia.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: March 3, 2015
    Assignee: Beth Israel Deconess Medical Center, Inc.
    Inventor: S. Ananth Karumanchi
  • Patent number: 8962002
    Abstract: A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent is provided. A method of making a composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent, said method comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent, is also provided. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising stimulating collagen beneath the skin defect is further provided.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: February 24, 2015
    Inventor: Ayman Boutros
  • Patent number: 8956632
    Abstract: A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent is provided. A method of making a composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent, said method comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent, is also provided. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising stimulating collagen beneath the skin defect is further provided.
    Type: Grant
    Filed: March 15, 2011
    Date of Patent: February 17, 2015
    Inventor: Ayman Boutros
  • Publication number: 20150024061
    Abstract: A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent is provided. A method of making a composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent, said method comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent, is also provided. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising stimulating collagen beneath the skin defect is further provided.
    Type: Application
    Filed: August 1, 2014
    Publication date: January 22, 2015
    Inventor: Ayman BOUTROS
  • Publication number: 20150024019
    Abstract: The disclosure provides polymers having antimicrobial activity and articles with the polymers coated thereon. The polymers include a first pendant group comprising a first cationic component, a second pendant group comprising a nonpolar component, and a third pendant group comprising an organosilane component. The disclosure also includes methods of coating medical device articles and body fluid-receiving substrates with the antimicrobial polymers. The methods further include the use of adhesion-promoting components.
    Type: Application
    Filed: May 25, 2011
    Publication date: January 22, 2015
    Inventors: Mahfuza B. Ali, Naiyong Jing, Valeri Lirine, Pradnya V. Nagarkar, Caroline M. Ylitalo, Nancy S. Lennhoff, Matthew T. Scholz, Ranjani V. Parthasarathy
  • Patent number: 8932573
    Abstract: Disclosed herein are cosmetic compositions for making up and/or coating keratinous fibers, said composition comprising: (a) at least one semicrystalline polymer; (b) at least one silicone elastomer blend comprising at least one silicone cross-polymer dispersed in at least one oil; (c) at least one hydrophilic gelling agent; and (d) an aqueous phase. Also disclosed herein are methods for making up and/or enhancing the appearance of keratinous fibers comprising applying said compositions to the keratinous fibers.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: January 13, 2015
    Assignee: L'Oreal
    Inventors: Ethan Alden-Danforth, Angeles Fonolla-Moreno
  • Publication number: 20150010631
    Abstract: The current invention involves the administration of negatively charged particles, such as polystyrene, PLGA, or diamond particles, to subjects to ameliorate inflammatory immune responses. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same negatively charged particles.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 8, 2015
    Applicant: Cour Pharmaceuticals Development Company
    Inventor: Daniel GETTS
  • Patent number: 8920841
    Abstract: A polymer system useful for in vivo delivery of a therapeutic agent is provided. The polymer system comprises a biocompatible biodegradable polymeric backbone that is capable of a reversible stimuli-induced transition from liquid to gel.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: December 30, 2014
    Inventors: Heather Sheardown, Scott Fitzpatrick, M.A. Jafar Mazumder
  • Publication number: 20140335045
    Abstract: A heparin mimicking polymer, its conjugate with bFGF, and method of making and using the same are disclosed. In particular, described herein are conjugates of biologic agents (e.g., bFGF) and heparin mimicking polymers having superior stability while retaining full native activity after a variety of stressors.
    Type: Application
    Filed: November 28, 2012
    Publication date: November 13, 2014
    Inventors: Heather D. Maynard, Thi Nguyen
  • Publication number: 20140314705
    Abstract: The present specification generally relates to compositions comprising a thermoresponsive polymer and methods of treating a soft tissue condition using such compositions.
    Type: Application
    Filed: July 3, 2014
    Publication date: October 23, 2014
    Inventors: Scott Whitcup, Orest Olejnik
  • Patent number: 8858926
    Abstract: An aqueous antibacterial polymer emulsion and coating compositions are provided. The aqueous antibacterial polymer emulsion comprising a polymer A, an oxidant and a metal complexed with a copolymer B comprising heterocyclic containing monomers; wherein the metal is selected from copper, silver, gold, tin, zinc and combinations thereof; and wherein the emulsion is heat stable. The coating compositions made therefrom provide persistent, broad spectrum antibacterial activity without discoloration problem upon exposure to heat and/or sun light.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: October 14, 2014
    Assignee: Rohm and Haas Company
    Inventors: Xiangting Dong, Shuang Liang, Tao Wang, Qingwei Zhang
  • Patent number: 8853297
    Abstract: The present invention refers to a method of infiltrating enamel for the prevention and/or treatment of carious lesions comprising (a) exposing an enamel area to a conditioner comprising hydrochloric acid; (b) exposing the conditioned enamel area to an infiltrant; and (c) curing the infiltrant. The present invention further refers to a kit for carrying out the method of infiltrating enamel, which comprises a conditioner comprising hydrochloric acid and an infiltrant comprising at least one low viscous dental resin. Alternatively, the kit comprises ready-to-use means for carrying out the method of infiltrating enamel, e.g. application strips with delivery pads soaked with conditioner or infiltrant. The present invention also refers to a method for identifying an infiltrant by calculation of the penetration coefficient, and to an infiltrant identified by the method having a penetration coefficient of >50 cm/s or comprising a low viscous light curing resin having a penetration coefficient of >50 cm/s.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: October 7, 2014
    Assignees: Charite Universitatsmedizin Berlin, Muhlbauer Technology GmbH
    Inventors: Hendrik Meyer-Lueckel, Sebastian Paris, Jan Mueller, Andrej M. Kielbassa, Bernd Detje
  • Patent number: 8846021
    Abstract: The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: September 30, 2014
    Assignee: Oligasis, LLC
    Inventor: Stephen A. Charles
  • Publication number: 20140286894
    Abstract: The present disclosure relates generally to crosslinked cation-binding polymers comprising monomers containing carboxylic acid groups, wherein the polymer contains calcium and/or magnesium cations that are counterions to about 15% to about 35% of the carboxylic acid groups in the polymer. The present disclosure also relates to methods of preparation of the polymers, and compositions, formulations, and dosage forms containing the polymers, and methods of using the polymers, compositions, formulations, and/or dosage forms to treat various diseases or disorders, including those involving ion and/or fluid imbalances.
    Type: Application
    Filed: January 10, 2012
    Publication date: September 25, 2014
    Applicant: Sorbent Therapeutics, Inc.
    Inventors: Alan D. Strickland, George M. Grass
  • Publication number: 20140286893
    Abstract: Disclosed herein are cosmetic compositions for making up and/or coating keratinous fibers, said composition comprising: (a) at least one semicrystalline polymer; (b) at least one silicone elastomer blend comprising at least one silicone cross-polymer dispersed in at least one oil; (c) at least one hydrophilic gelling agent; and (d) an aqueous phase. Also disclosed herein are methods for making up and/or enhancing the appearance of keratinous fibers comprising applying said compositions to the keratinous fibers.
    Type: Application
    Filed: March 22, 2013
    Publication date: September 25, 2014
    Applicant: L'OREAL
    Inventors: Ethan ALDEN-DANFORTH, Angeles FONOLLA-MORENO
  • Publication number: 20140271530
    Abstract: Methods and materials relating to a medicament preparation comprising a curcuminoid component and a eudragit component provided as a curcuminoid-eudragit complex, which enhance the bioavailability of the curcumin component and are useful for the treatment of various diseases including cancer, neurodegeneration, inflammation, and immunodeficiency. In some aspects, the curcuminoid component comprises curcumin to prepare a curcumin-eudragit complex and a medicament comprising curcumin-eudragit complexes.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Inventors: Hemachand Tummala, Sunny Kumar
  • Publication number: 20140255458
    Abstract: According to an aspect of the invention, injectable bulking compositions are provided which contain the following: (a) fibers that are configured to prevent migration to locations in the body remote from the injection site, for example, because they have a minimum length that is sufficiently large to prevent migration of the fibers and/or because they have surface features that stimulate host tissue response to lock the fibers in position and (b) a carrier in an amount effective to render the composition injectable.
    Type: Application
    Filed: May 20, 2014
    Publication date: September 11, 2014
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Jianmin Li, Michael Madden
  • Patent number: 8822415
    Abstract: The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: September 2, 2014
    Assignee: Stemnion, Inc.
    Inventors: Catherine J. Trumpower, George L. Sing, Linda O. Palladino
  • Patent number: 8815228
    Abstract: A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent is provided. A method of making a composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent, said method comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent, is also provided. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising stimulating collagen beneath the skin defect is further provided.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: August 26, 2014
    Inventor: Ayman Boutros
  • Patent number: 8795647
    Abstract: The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: August 5, 2014
    Assignee: The Research Foundation for The State University of New York
    Inventors: Nicole Sampson, Kathlyn Parker, Airong Song
  • Patent number: 8796476
    Abstract: Pest controlling compositions exhibiting enhanced pesticidal activity levels and methods for preparing the same are disclosed. In one embodiment, a method includes providing a liquid composition that includes at least one pesticide and at least one co-ingredient that enhances pesticidal activity of the composition compared to a composition dissimilar only in not having the at least one co-ingredient. The at least one co-ingredient may include at least one metal oxide, a combination of at least one transition metal salt and at least one proteinaceous material or a combination of at least one proteinaceous material and at least one polymeric material. The method further includes spray drying the liquid composition to provide a solid composition. In one aspect of this embodiment, the solid composition provided by the spray drying exhibits enhanced pesticidal activity compared to the liquid composition.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: August 5, 2014
    Assignee: Dow AgroSciences, LLC
    Inventors: Stephen L. Wilson, Lei Liu, James D. Thomas, Raymond E. Boucher, Jr., James E. Dripps, Margaret S. Kempe, Martin C. Logan, Douglas J. Linscott, John M. Atkinson
  • Publication number: 20140212373
    Abstract: A multi-vinylsulfone containing molecule is described herein. The multi-vinylsulfone containing molecule can be formed by dissolving a water soluble polymer containing a hydroxyl group in an aqueous solution to form a polymer solution; adding a molecule containing two vinylsulfone groups to the polymer solution; and forming a modified polymer by controlling a number of the vinylsulfone groups that are added to the polymer. A hydrogel is also described herein that can include the multi-vinylsulfone containing molecule and a multi-thiol containing molecule. The hydrogel can be formed from an aqueous solution that includes the multi-vinylsulfone containing molecule and the multi-thiol containing molecule by undergoing gelatation upon delivery to a site in the body. Also described is a drug delivery system that employs the hydrogel.
    Type: Application
    Filed: June 15, 2012
    Publication date: July 31, 2014
    Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Ying Chau, Yu Yu
  • Patent number: 8784791
    Abstract: A method is provided for preparing water-soluble polymer derivatives bearing a terminal N-succinimidyl ester. The method involves the hydrolyzing an ortho ester of a water-soluble polymer so as provide the corresponding acid and subsequently esterifying the acid.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: July 22, 2014
    Assignee: Nektar Therapeutics
    Inventor: Antoni Kozlowski
  • Patent number: 8784793
    Abstract: A biological coating material that includes a polymerizable polyacrylate monomer; a volatile liquid; a polymer selected from a synthetic rubber, a natural rubber, and a thermoplastic elastomer. The biological liquid coating material forms a coating or bandage in the form of a film that when applied and adhered to a surface or to the skin of a user inhibits the application surface from adhering to another surface.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: July 22, 2014
    Assignee: Rochal Industries, LLP
    Inventors: Ann Beal Salamone, Joseph C. Salamone
  • Patent number: 8784849
    Abstract: Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two termini, a first terminus being covalently bonded to a hydroxyapatite-targeting moiety, such as a bisphosphonate, and a second terminus covalently bonded to a chemically reactive group, wherein said chemically reactive group is protected or unprotected. Methods of preparing and using hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are also provided.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: July 22, 2014
    Assignee: Nektar Therapeutics
    Inventors: Michael J. Roberts, Antoni Kozlowski
  • Publication number: 20140199376
    Abstract: Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
    Type: Application
    Filed: February 20, 2014
    Publication date: July 17, 2014
    Applicant: NanoPharmaceuticals LLC
    Inventors: Shaker A. Mousa, Faith B. Davis, Paul J. Davis
  • Publication number: 20140186416
    Abstract: A method for repairing or replacing damaged tissue, or for providing post-surgical augmentation, comprising administering a pliable biocompatible material and a physiologically acceptable suspending agent to a patient is disclosed. Copolymers of unsubstituted acrylate and substituted acrylate are disclosed as pliable biocompatible materials.
    Type: Application
    Filed: March 7, 2014
    Publication date: July 3, 2014
    Inventor: Ayman BOUTROS