Monomer Contains Oxygen Patents (Class 424/78.37)
  • Patent number: 11919992
    Abstract: A method for producing customized object is provided. A resin (e.g. plastic or cellulose) is heated and a quaternary salt is added. The resulting admixture is used in forming a material that embodies customized characteristics. In another embodiment, a halogen-containing polymer has a quaternary molecule covalently bonded to it that results in customized properties.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: March 5, 2024
    Assignee: Research Foundation of the City University of New York
    Inventors: William J. Blanford, Gregory D. O'Mullan, Robert Engel
  • Patent number: 11896472
    Abstract: A coated surgical mesh, the coated surgical mesh comprising: a surgical mesh, the surgical mesh comprising a first surface and a second surface; and a tissue ingrowth-preventing coating applied to the second surface of the surgical mesh; wherein the tissue ingrowth-preventing coating penetrates a controllable amount part way through the surgical mesh.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: February 13, 2024
    Assignee: Grant Technologies LLC
    Inventors: John W. Huelskamp, Andrew R. Leopold
  • Patent number: 11872195
    Abstract: Compositions and methods that rapidly and selectively modify hematopoietic stem cells (or cells derived therefrom) to achieve therapeutic objectives by providing for transient expression of nucleic acids are described. The transient expression leads to permanent therapeutic changes in the modified cells, referred to herein as “hit and run” effects.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: January 16, 2024
    Assignee: Fred Hutchinson Cancer Center
    Inventors: Matthias Stephan, Howell F. Moffett
  • Patent number: 11730558
    Abstract: A medical instrument, including an atomic layer deposition, ALD, coating to indicate the type of the medical instrument, and use of ALD to indicate number of re-uses of a medical instrument.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: August 22, 2023
    Assignee: Picosun Oy
    Inventors: Jani Kivioja, Niku Oksala
  • Patent number: 11666685
    Abstract: The present disclosure provides a biomaterial and a method for promoting tissue regeneration by using the biomaterial.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: June 6, 2023
    Assignee: WIZDOM INC.
    Inventors: Yi-Chung Lai, Wen-Yi Chen, Yung-Lung Liu
  • Patent number: 11654410
    Abstract: A method for manufacturing microcapsules containing an active substance, the method including: providing an aqueous solution of a surfactant, an oily phase comprising the active substance and a first monomer, and a polar phase comprising a second monomer; preparing an oil-in-water emulsion by adding the oily phase to the aqueous solution of the surfactant; adding the polar phase to the oil-in-water emulsion, in order to obtain a polymer in a reaction mixture, by polymerization of the first monomer and the second monomer; isolating the microcapsules, including a wall formed by the polymer and containing the active substance, from the reaction mixture; wherein the polymer is a poly(beta-amino ester). Microcapsules obtained by the method.
    Type: Grant
    Filed: May 16, 2020
    Date of Patent: May 23, 2023
    Assignee: GEM INNOV
    Inventors: Yves Ortais, Thierry Ribeiro, Kaouthar Oudoua, The Hien Ho, Didier Gigmes, Catherine Guillaneuf, Yohann Guillaneuf
  • Patent number: 11653995
    Abstract: A surgical headlight system has a headlamp. The surgical headlight system can further include a headwear structure, configured to be worn on a surgeon's head during surgery, supporting the headlamp. The surgical headlight system can further include a video camera configured to record surgery. The headlamp, the headwear structure and the video camera all have an exterior surface. An antimicrobial coating is applied to the exterior surface of the headlamp, the exterior surface of the video camera, and/or the exterior surface of the headwear structure. The antimicrobial coating includes a silane quaternary ammonium ion or salt thereof. The antimicrobial coating imparts antimicrobial properties onto the exterior surface to which it is applied, such as the exterior surface of the headlamp.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: May 23, 2023
    Assignee: Parasol Medical, LLC
    Inventor: Patrick E. Eddy
  • Patent number: 11613516
    Abstract: Disclosed are methods for preparing compounds of Formula 1 and 1A. The first method utilizes a benzyl carbamate amine protecting group and an intermediate of Formula 4. The second method utilizes a tert-butyl carbamate amine protecting group and an intermediate of Formula 7. The third method utilizes a dibenzyl amine protecting group. Also disclosed is a compound, phenylmethyl N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]carbamate (a compound of Formula 4). Further disclosed is a method for preparing a compound of Formula 14 from a compound of Formula 15 and a compound of Formula 1 or 1A.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: March 28, 2023
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Joerg Bruening
  • Patent number: 11576744
    Abstract: Provided herein are methods for treating nephrolithiasis and protecting the urothelium and inner lining of the kidney from thermal damage during lithotripsy by use of a thermosensitive bio-adhesive hydrogel. The described method dramatically improved the efficiency and effectiveness of stone clearance compared to conventional techniques while providing protection to the urothelium from potentially damaging temperature spikes.
    Type: Grant
    Filed: March 24, 2022
    Date of Patent: February 14, 2023
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UROGEN PHARMA LTD.
    Inventors: Ralph V. Clayman, Pengbo Jiang, Mark Schoenberg, Omer Tsipori
  • Patent number: 11299587
    Abstract: The present invention provides a raw material for bulk drugs and a pharmaceutical additive which provide excellent formulation stability and excellent over-time stability of drug efficacy when used to modify a bulk drug, a polypeptide, a bioactive protein, an enzyme, and the like. The present invention relates to a raw material for bulk drugs or a pharmaceutical additive, containing: a polyether composition (A) represented by formula (1), wherein the polyether composition (A) has a unimodal molecular weight distribution, the polyether composition (A) has a ratio (Mw/Mn) of the weight average molecular weight (Mw) to the number average molecular weight (Mn) of 1.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: April 12, 2022
    Assignee: SANYO CHEMICAL INDUSTRIES, LTD.
    Inventors: Shihei Motofuji, Kenichiro Nakai, Kyosuke Michigami, Itsuka Matsumoto
  • Patent number: 11252971
    Abstract: The present invention is directed to a thermoplastic packaging film coated with an antimicrobial coating, a method for the preparation of the coated film and packaging articles made with the film.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: February 22, 2022
    Assignee: Cryovac, LLC
    Inventors: Giorgia Francini, Valeria Vigano, Roberto Forloni
  • Patent number: 11234953
    Abstract: Described herein is the surprising discovery that ketone bodies protect cell and tissues from ionizing radiation. Based on this finding, methods of protecting animal tissue and cells from damage caused by radiation exposure are disclosed which include, contacting the tissue with a therapeutically effective amount of an agent including at least one ketone ester, thereby protecting the tissue from radiation damage. Ketone esters can be used to minimize, reduce and/or prevent tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: February 1, 2022
    Assignees: TDELTAS LIMITED, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Richard Lewis Veech, Kieran Clarke
  • Patent number: 11198890
    Abstract: The subject invention relates to a process of preparing (R)-3-hydroxybutyric acid or a salt thereof by one-step fermentation with a nonpathogenic microorganism. The fermentation of (R)-3-hydroxybutyric acid was performed by supplying with certain carbon and nitrogen sources. These microorganisms include a Glutamic acid Bacterium HR057 strain or one type of genetically engineered Corynebacterium Glutamicum.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: December 14, 2021
    Assignee: NNB Nutrition USA, LLC
    Inventors: Kylin Liao, Wenchao Fan
  • Patent number: 11021696
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: June 1, 2021
    Assignees: Children's Medical Center Corporation, Sangamo Therapeutics, Inc.
    Inventors: Stuart H. Orkin, Andreas Reik, Fyodor Urnov
  • Patent number: 10954336
    Abstract: A cyclic poly L-lactic acid composition having a pH of 6 to 7 by the polymer itself.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: March 23, 2021
    Assignee: SCRUM CO., LTD.
    Inventors: Hitoshi Nakamura, Susumu Sugiki
  • Patent number: 10815540
    Abstract: The present invention relates to a compound inducing activation of HLA-E-restricted CD8 T cells and/or NK cells in a human subject, and reducing HIV viral load, such as glatiramer acetate and glatiramer acetate related active substances and products, for use in the treatment of HIV infection. Macaques chronically infected by SIV have been treated with glatiramer acetate. One of the animals had already progressed to the stage of AIDS. We injected 18 mg of glatiramer acetate three times per week for only 2 weeks. Surprisingly, a strong impact on viral load was observed in response to the treatment. Viremia decreased by 1 log during glatiramer acetate treatment. Even more surprising was the fact that this decrease persisted after stopping the treatment reaching almost a 2 logs decrease in one animal. This is a major result as compared to cART as stopping cART leads to a rebound of the viral load within days.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: October 27, 2020
    Assignee: INSTITUT PASTEUR
    Inventors: Nicolas Huot, Beatrice Jacquelin, Michaela Muller-Trutwin
  • Patent number: 10588877
    Abstract: ?-hydroxybutyric acid in combination with ?-hydroxybutyrate salts are useful to induce ketosis, achieving blood ketone levels of (0.5-6.0 mmol/L), with or without dietary restriction, and without inducing harmfully high mineral loads in the blood. The combination of ?-hydroxybutyric acid and salt results in substantial improvements in metabolic biomarkers related to insulin resistance, diabetes, weight loss, and physical performance & endurance in a short period of time. Further, use of these supplements to achieve ketosis yields a significant elevation of blood ketones and reduction of blood glucose levels. These acid/salt mixtures are also useful for suppressing appetite, preventing epileptic seizures, and treating cancer.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: March 17, 2020
    Assignee: SavInd, Inc.
    Inventor: Patrick Arnold
  • Patent number: 10584224
    Abstract: A process for manufacturing a thermoset polyester foam includes the following successive steps: (a) providing an expandable and thermosetting composition containing a polyol component including at least one element selected from glycerol, diglycerol and glycerol oligomers; a polyacid component including citric acid; a surfactant selected from alkyl polyglycosides and mixtures of an anionic surfactant and a cationic surfactant, and an esterification catalyst; (b) introducing the expandable and thermosetting composition into a mold or applying the expandable composition to a support; and (c) heating the expandable and thermosetting composition at a temperature at least equal to 135° C. so as to react the polyol component with the polyacid component and form a block of thermoset polyester foam.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: March 10, 2020
    Assignee: SAINT-GOBAIN ISOVER
    Inventors: Marie Savonnet, Edouard Obert
  • Patent number: 10519173
    Abstract: A process for the selective removal of a component from a liquid phase and subsequently returning the component to a liquid phase is disclosed. A novel compound of formula (I) [SUP]-[[L]-[G]]a (I) in which L is a linking group, G is an aryl group having a leaving group LG selected from Cl, Br, I, sulfonate such as triflate, a diazo group, a nitrile, an ester and an alkoxy group and substituent Q is selected from H, NR2, OR, CO2R, F, Cl, NO2 CN and SUP is a support having a plurality of groups -[L]-[G] bound to the support is contacted with the liquid phase to bind the component to the compound I thereby forming a captured component which is separated from and may be returned to the liquid phase. The compound I is especially useful in binding homogeneous catalysts to remove it from a reaction medium and selectively returning the catalyst to the reaction medium at a later stage. The compound is particularly useful for cross-coupling reactions, for example in Suzuki reactions.
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: December 31, 2019
    Assignees: PHOSPHONICS LTD
    Inventors: Paul Murray, Robin Wilkes, Christopher North
  • Patent number: 10398438
    Abstract: The present disclosure is directed to the use of fusogenic compounds such as polyethylene glycol (PEG) in combination with antioxidants, calcium-containing and calcium-free solutions for treating damaged nerves, such as for reconnecting severed nerves.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: September 3, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: George D. Bittner
  • Patent number: 10324747
    Abstract: In one embodiment, for each of the nodes forming a cluster that share a cluster shared volume (CSV), a remote connection is established with an operating system (OS) management interface of an operating system of the node to query and to obtain OS configuration information concerning a VMM hosting one or more virtual machine (VMs) within the node. A remote connection is established with a VMM interface of the VMM of the node to query and to obtain VM information concerning each of the VMs hosted by the VMM in the node. An analysis is performed on the OS configuration information and the VM information in view of a set of management rules. A report is generated based on the analysis, the report including information indicating which of the management rules has been violated.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: June 18, 2019
    Assignee: EMC IP HOLDING COMPANY LLC
    Inventors: Anupam Chakraborty, Tushar Dethe, Subhashish Mallik
  • Patent number: 10220096
    Abstract: A hydrogel composition includes: (1) a polymer network including a first water-soluble polymer and a second water-soluble polymer that are crosslinked through dynamic bonds; and (2) a catalyst to modulate a rate of exchange of crosslinking of the polymer network.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: March 5, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yan Xia, Junzhe Lou, Ovijit Chaudhuri
  • Patent number: 10188749
    Abstract: Compositions and methods that rapidly and selectively modify hematopoietic stem cells (or cells derived therefrom) to achieve therapeutic objectives by providing for transient expression of nucleic acids are described. The transient expression leads to permanent therapeutic changes in the modified cells, referred to herein as “hit and run” effects.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: January 29, 2019
    Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Matthias Stephan, Howell F. Moffett
  • Patent number: 10136894
    Abstract: The present disclosure is directed to the use of fusogenic compounds such as polyethylene glycol (PEG) in combination with antioxidants, calcium-containing and calcium-free solutions for treating damaged nerves, such as for reconnecting severed nerves.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: November 27, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: George D. Bittner
  • Patent number: 10098830
    Abstract: The application relates to oral care compositions comprising substantive polyesters formed from xylitol, polycarboxylic acids (or esters, acid halides or anhydrides thereof) and optionally arginine. The formed polyesters or polyesteramides are active in biofilm inhibition and dissolution to maintain clean teeth.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: October 16, 2018
    Assignee: BASF SE
    Inventors: Ted Deisenroth, Glen Thomas Cunkle, Lauren Junker, Michael Kuepfert, Paul Odorisio, Steven N. Saunders, Vishal Ramnarine, Neethu Abraham
  • Patent number: 9981069
    Abstract: The present invention relates to methods and compositions for rendering a surface resistant to bio-film formation by a combination of an alkanediol and an antimicrobial agent (and, optionally, an organic hydroxy acid). The invention provides for compositions which may be used to render surfaces bio-film resistant, articles having bio-film resistant surfaces, and methods for their preparation. The present invention may be advantageously applied to medical articles as well as articles used in non-medical contexts, such as child care or food preparation.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: May 29, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Shanta Modak, Arnab Kumar Ghosh, Ronald Citron, Santoshkumar Hanmantrao Dongre, Nayana Baiju
  • Patent number: 9968684
    Abstract: The invention relates to polymer-drug conjugate for delivering a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID). The invention also relates to drug delivery systems comprising the polymer-NSAID conjugate. The polymer-NSAID conjugates comprise a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID) conjugated to a biodegradable polymer backbone by an ester linkage.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: May 15, 2018
    Assignee: POLYACTIVA PTY LTD
    Inventors: Asha Marina D'Souza, Andrew Craig Donohue, Russell John Tait, Florian Hans Maximilian Graichen, Sarah Man Yee Ng, Adrian Sulistio
  • Patent number: 9872491
    Abstract: Provided are compositions comprising aconitic acid, one or more acids selected from the group consisting of adipic acid, glutaric acid, and combinations thereof, and a carrier. Also provided are methods of disrupting a biofilm comprising applying to a surface having a biofilm a composition of the present invention.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: January 23, 2018
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Robert J. Gambogi, Patricia L. Golas, Anthony R. Geonnotti, III, Benjamin Serbiak
  • Patent number: 9809823
    Abstract: Materials and methods related to using multimeric DNA aptamers to treat demyelinating diseases are provided herein.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: November 7, 2017
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Louis J. Maher, III, Moses Rodriguez
  • Patent number: 9744125
    Abstract: A method of reducing or inhibiting the contraction or communication of viral illnesses is proposed. Application of a virucidal preparation containing one or more organic acids (e.g. malic acid) with or without a surfactant (e.g. sodium C14-C16 olefin sulfonate) in a carrier agent (e.g. petrolatum) to the face of well individuals will reduce the chance that they contract illness with viral illnesses such as viral upper respiratory illnesses, influenza, viral gastroenteritis, viral rhinosinusitis, viral cold sores, and viral conjunctivitis. Application of said ointment to the nares of individuals with a VURI will reduce the chance they transmit the illness by reducing self-contamination of their hands when touching their nose. In addition, individuals suffering from a cold or influenza may reduce the duration or severity of illness by application of the nasal antiviral ointment. The ointment is most effective when applied with a clean applicator two or three times daily.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: August 29, 2017
    Assignee: NUANCE HEALTH, LLC
    Inventor: Kent C. New
  • Patent number: 9655863
    Abstract: The invention relates to matrix and layer compositions comprising a first polymer. The matrix and layer compositions are useful in the delivery of bioactives. In particular, the matrices and layers may have advantageous properties including mechanical properties and protection of bioactives and may also provide for pH-dependent release of a bioactive.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: May 23, 2017
    Assignee: Novus International, Inc.
    Inventors: Houston Stephen Smith, Matthew J. Fischer, Graciela B. Arhancet, Rangarani Karnati, John A. Hume, Xiaojun Wang
  • Patent number: 9631118
    Abstract: Disclosed is an anti-bacterial and anti-fingerprint coating composition for forming a multi-functional coating layer having both anti-bacterial functions and anti-fingerprint functions on surfaces of touchscreens provided in portable terminals such as cellular phones, of panels or the like, provided in display devices such as liquid crystal displays (LCDs) or plasma display panels (PDPs), by a dry deposition method.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: April 25, 2017
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Byung Ha Park, Soo Jin Park, Jun Sung Chung, In Oh Hwang
  • Patent number: 9593201
    Abstract: Amide compounds are defined and are polymerized to create polyesters and polyurethanes having amide units bearing a pendant functional group, where the nitrogen atom of the amide group is part of the polymer backbone. The pendant functional group of the functionalized amide polymer may be modified or added by post polymerization functionalization of the functionalized amide polymer. The pendant functional group of the functionalized amide polymer may include a protecting group that may be removed after polymerization. The pendant functional groups of the functionalized amide polymers may be used to modulate the physical, chemical and biological properties of the polymers.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: March 14, 2017
    Assignee: The University of Akron
    Inventors: Abraham Joy, Sachin Gokhale, Ying Xu
  • Patent number: 9469728
    Abstract: Disclosed herein are pH- and temperature-sensitive block copolymer with excellent safety and a method for preparing the same and a hydrogel and a drug carrier using the block copolymer. According to the present invention, the pH- and temperature-sensitive block copolymer comprises: obtained by copolymerization of: (a) polyethylene glycol-based compound (A); and (b) poly (?-amino ester)-based oligomer (B) or poly (amido amine)-based oligomer (C) or coupling of mixture (D) thereof. In order to control biodegradation rate, the block copolymer is mixed with poly (amido amine)-based oligomer instead of the poly (?-amino ester)-based oligomer and then coupling them.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: October 18, 2016
    Assignee: SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE
    Inventors: Doo Sung Lee, Minh Khanh Nguyen, Bong Sup Kim
  • Patent number: 9452377
    Abstract: A nanoporous ceramic membrane and preparation method thereof is provided. The nanoporous ceramic membrane is prepared by halloysite nanotubes (HNTs), and its porosity is between 35% to 85%. This method comprises steps as following: HNTs and polymers with a certain ratio are dispersed in organic solvent, and HNTs/polymer composite fibers are prepared through electrospinning method; after the HNTs/polymers composite fibers are laminated, they are sintered at high temperature in a certain or vacuum atmosphere, and a nanoporous ceramic membrane is obtained. Ceramic membrane prepared by this method is corrosion resistant, thermal resistant, and have large specific surface area, it may widely applied in the field of filtration, catalyst carrier and purification of high-temperature gas, etc.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: September 27, 2016
    Assignee: THE HKUST FOK YING TUNG RESEARCH INSTITUTE
    Inventors: Jingshen Wu, Dong Lv, Zheming Zhang, Dan Li
  • Patent number: 9452143
    Abstract: The invention relates to matrix and layer compositions comprising a first polymer. The matrix and layer compositions are useful in the delivery of bioactives. In particular, the matrices and layers may have advantageous properties including mechanical properties and protection of bioactives and may also provide for pH-dependent release of a bioactive.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: September 27, 2016
    Assignee: NOVUS INTERNATIONAL, INC.
    Inventors: Houston Stephen Smith, Matthew J. Fischer, Graciela B. Arhancet, Rangarani Karnati, John A. Hume, Xiaojun Wang
  • Patent number: 9410964
    Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: August 9, 2016
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
  • Patent number: 9395374
    Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: July 19, 2016
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
  • Patent number: 9370502
    Abstract: A composition comprising i) oligomeric lactic acid with the following formula (I) wherein n is an integer from 2 to 20, from 2 to 19, or from 2 to 18, and wherein from about 10 to about 20% w/w of the total weight of the oligomeric lactic acid is a trimer, HL3, having n equal to 2, wherein the number average molecular weight Mn of the oligomeric lactic acid is from about 200 to about 500, and ii) a mucoadhesive agent.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: June 21, 2016
    Assignee: LACCURE AB
    Inventors: Olov Sterner, Sören Kulstad, Jeanette Robertsson, Malgorzata Sznitowska, Werner Schubert
  • Patent number: 9308240
    Abstract: Insulin or a peroxisome proliferator-activated receptor (PPAR) agonist provides reliable and effective prevention of scarring in human skin, or at least a reduction in the severity of scarring. The application of insulin or the PPAR agonist to wounds topically or by local injection is particularly advantageous since it simultaneously reduces/prevents scarring while enhancing re-epithelialization of the wound and thus provides a dual action wound healing treatment. The present invention accordingly provides a highly effective prophylactic treatment for any individual suffering tissue trauma to reduce and/or prevent normal and/or pathological scarring.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: April 12, 2016
    Assignee: Pharmecosse Limited
    Inventors: Claire Linge, Ian Paul Mackie
  • Patent number: 9175114
    Abstract: Hair treatment compositions are disclosed comprising a ?-amino ester compound in a cosmetically acceptable vehicle, such as a spray or cream. In embodiments, the compounds include a polybutadiene moiety. Methods of treating hair with the compositions to impart volume, texture and definition are also disclosed.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: November 3, 2015
    Assignee: Living Proof, Inc.
    Inventors: David Thomas Puerta, Susan Alice Thiell, Ronald P. McLaughlin, Daniel Griffith Anderson
  • Patent number: 9150867
    Abstract: Materials and methods related to using multimeric DNA aptamers to treat demyelinating diseases are provided herein.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: October 6, 2015
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Louis J. Maher, III, Moses Rodriguez
  • Patent number: 9101666
    Abstract: Poly(?-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: August 11, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert S. Langer, David M. Lynn, David A. Putnam, Mansoor M. Amiji, Daniel Griffith Anderson
  • Publication number: 20150147399
    Abstract: The present invention provides a pharmaceutical composition formulated for oral delivery, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and a biologically active protein or peptide suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of a therapeutic protein or peptide.
    Type: Application
    Filed: December 9, 2014
    Publication date: May 28, 2015
    Inventors: Alexander Vol, Orna Gribova
  • Patent number: 9040034
    Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: May 26, 2015
    Assignees: International Business Machines Corporation, Agency for Science, Technology and Research
    Inventors: James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Yi Yan Yang
  • Publication number: 20150139935
    Abstract: Provided herein is technology relating to treating sleep apnea and particularly, but not exclusively, to treating sleep apnea with immunotherapeutics and/or anti-inflammatory drugs such as beta-interferons and glatiramer acetate.
    Type: Application
    Filed: June 14, 2013
    Publication date: May 21, 2015
    Applicant: The Regents of The University of Michigan
    Inventors: Tiffany J. Braley, Benjamin Segal, Ronald D. Chervin
  • Publication number: 20150132251
    Abstract: Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 14, 2015
    Inventors: Kazuro Lee Fujimoto, Jianjun Guan, Bradley B. Keller, Kimimasa Tobita, William R. Wagner
  • Patent number: 9028807
    Abstract: A method of forming a biocidal halogenated organic/inorganic composite material may include providing at least one inorganic precursor, providing at least one organic agent, precipitating an organic/inorganic composite material by contacting the at least one inorganic precursor with the at least one organic agent, and halogenating the organic/inorganic composite material by contacting the organic/inorganic composite material with a halogen. Also, a halogenated organic/inorganic composite material may include an inorganic composition comprising a metal oxide and a halogenated organic composition. The inorganic composition and the halogenated organic composition are dispersed throughout the composite material.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 12, 2015
    Assignee: UES, Inc.
    Inventors: Matthew B. Dickerson, Rajesh R. Naik
  • Patent number: 9017644
    Abstract: The present invention relates to dendrimer compositions configured for treating inflammatory disorders and autoimmune disorders, and related methods of synthesis. Specifically, the present invention relates to methods for treating rheumatoid arthritis with PAMAM dendrimers having functional ligands configured for treating rheumatoid arthritis (e.g., therapeutic agents, pro-drugs, targeting agents, trigger agents, imaging agents) (e.g., methotrexate).
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: April 28, 2015
    Assignee: The Regents of the University of Michigan
    Inventors: James R. Baker, Jr., Larry A. Sternson, David Repp, Deborah Ladenheim
  • Publication number: 20150110733
    Abstract: The present invention provides a method for treating a human subject afflicted with multiple sclerosis or a single clinical attack consistent with multiple sclerosis with a pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier, comprising the steps of: (i) determining a genotype of the subject at a location corresponding to the location of one or more single nucleotide polymorphisms (SNPs) selected from the group consisting of: Group 1, (ii) identifying the subject as a predicted responder to glatiramer acetate if the genotype of the subject contains one or more A alleles at the location of Group 2, one or more C alleles at the location of Group 3, one or more G alleles at the location of Group 4, or one or more T alleles at the location of kgp18432055, kgp279772, kgp3991733 or kgp7242489; and (iii) administering the pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier to the subject only if the subject is identif
    Type: Application
    Filed: October 21, 2014
    Publication date: April 23, 2015
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Amir TCHELET, Michael HAYDEN, Liat HAYARDENY, Colin James Douglas ROSS, Iris GROSSMAN, David LADKANI