Monomer Contains Oxygen Patents (Class 424/78.37)
  • Patent number: 10324747
    Abstract: In one embodiment, for each of the nodes forming a cluster that share a cluster shared volume (CSV), a remote connection is established with an operating system (OS) management interface of an operating system of the node to query and to obtain OS configuration information concerning a VMM hosting one or more virtual machine (VMs) within the node. A remote connection is established with a VMM interface of the VMM of the node to query and to obtain VM information concerning each of the VMs hosted by the VMM in the node. An analysis is performed on the OS configuration information and the VM information in view of a set of management rules. A report is generated based on the analysis, the report including information indicating which of the management rules has been violated.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: June 18, 2019
    Assignee: EMC IP HOLDING COMPANY LLC
    Inventors: Anupam Chakraborty, Tushar Dethe, Subhashish Mallik
  • Patent number: 10220096
    Abstract: A hydrogel composition includes: (1) a polymer network including a first water-soluble polymer and a second water-soluble polymer that are crosslinked through dynamic bonds; and (2) a catalyst to modulate a rate of exchange of crosslinking of the polymer network.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: March 5, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yan Xia, Junzhe Lou, Ovijit Chaudhuri
  • Patent number: 10188749
    Abstract: Compositions and methods that rapidly and selectively modify hematopoietic stem cells (or cells derived therefrom) to achieve therapeutic objectives by providing for transient expression of nucleic acids are described. The transient expression leads to permanent therapeutic changes in the modified cells, referred to herein as “hit and run” effects.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: January 29, 2019
    Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Matthias Stephan, Howell F. Moffett
  • Patent number: 10136894
    Abstract: The present disclosure is directed to the use of fusogenic compounds such as polyethylene glycol (PEG) in combination with antioxidants, calcium-containing and calcium-free solutions for treating damaged nerves, such as for reconnecting severed nerves.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: November 27, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: George D. Bittner
  • Patent number: 10098830
    Abstract: The application relates to oral care compositions comprising substantive polyesters formed from xylitol, polycarboxylic acids (or esters, acid halides or anhydrides thereof) and optionally arginine. The formed polyesters or polyesteramides are active in biofilm inhibition and dissolution to maintain clean teeth.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: October 16, 2018
    Assignee: BASF SE
    Inventors: Ted Deisenroth, Glen Thomas Cunkle, Lauren Junker, Michael Kuepfert, Paul Odorisio, Steven N. Saunders, Vishal Ramnarine, Neethu Abraham
  • Patent number: 9981069
    Abstract: The present invention relates to methods and compositions for rendering a surface resistant to bio-film formation by a combination of an alkanediol and an antimicrobial agent (and, optionally, an organic hydroxy acid). The invention provides for compositions which may be used to render surfaces bio-film resistant, articles having bio-film resistant surfaces, and methods for their preparation. The present invention may be advantageously applied to medical articles as well as articles used in non-medical contexts, such as child care or food preparation.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: May 29, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Shanta Modak, Arnab Kumar Ghosh, Ronald Citron, Santoshkumar Hanmantrao Dongre, Nayana Baiju
  • Patent number: 9968684
    Abstract: The invention relates to polymer-drug conjugate for delivering a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID). The invention also relates to drug delivery systems comprising the polymer-NSAID conjugate. The polymer-NSAID conjugates comprise a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID) conjugated to a biodegradable polymer backbone by an ester linkage.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: May 15, 2018
    Assignee: POLYACTIVA PTY LTD
    Inventors: Asha Marina D'Souza, Andrew Craig Donohue, Russell John Tait, Florian Hans Maximilian Graichen, Sarah Man Yee Ng, Adrian Sulistio
  • Patent number: 9872491
    Abstract: Provided are compositions comprising aconitic acid, one or more acids selected from the group consisting of adipic acid, glutaric acid, and combinations thereof, and a carrier. Also provided are methods of disrupting a biofilm comprising applying to a surface having a biofilm a composition of the present invention.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: January 23, 2018
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Robert J. Gambogi, Patricia L. Golas, Anthony R. Geonnotti, III, Benjamin Serbiak
  • Patent number: 9809823
    Abstract: Materials and methods related to using multimeric DNA aptamers to treat demyelinating diseases are provided herein.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: November 7, 2017
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Louis J. Maher, III, Moses Rodriguez
  • Patent number: 9744125
    Abstract: A method of reducing or inhibiting the contraction or communication of viral illnesses is proposed. Application of a virucidal preparation containing one or more organic acids (e.g. malic acid) with or without a surfactant (e.g. sodium C14-C16 olefin sulfonate) in a carrier agent (e.g. petrolatum) to the face of well individuals will reduce the chance that they contract illness with viral illnesses such as viral upper respiratory illnesses, influenza, viral gastroenteritis, viral rhinosinusitis, viral cold sores, and viral conjunctivitis. Application of said ointment to the nares of individuals with a VURI will reduce the chance they transmit the illness by reducing self-contamination of their hands when touching their nose. In addition, individuals suffering from a cold or influenza may reduce the duration or severity of illness by application of the nasal antiviral ointment. The ointment is most effective when applied with a clean applicator two or three times daily.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: August 29, 2017
    Assignee: NUANCE HEALTH, LLC
    Inventor: Kent C. New
  • Patent number: 9655863
    Abstract: The invention relates to matrix and layer compositions comprising a first polymer. The matrix and layer compositions are useful in the delivery of bioactives. In particular, the matrices and layers may have advantageous properties including mechanical properties and protection of bioactives and may also provide for pH-dependent release of a bioactive.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: May 23, 2017
    Assignee: Novus International, Inc.
    Inventors: Houston Stephen Smith, Matthew J. Fischer, Graciela B. Arhancet, Rangarani Karnati, John A. Hume, Xiaojun Wang
  • Patent number: 9631118
    Abstract: Disclosed is an anti-bacterial and anti-fingerprint coating composition for forming a multi-functional coating layer having both anti-bacterial functions and anti-fingerprint functions on surfaces of touchscreens provided in portable terminals such as cellular phones, of panels or the like, provided in display devices such as liquid crystal displays (LCDs) or plasma display panels (PDPs), by a dry deposition method.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: April 25, 2017
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Byung Ha Park, Soo Jin Park, Jun Sung Chung, In Oh Hwang
  • Patent number: 9593201
    Abstract: Amide compounds are defined and are polymerized to create polyesters and polyurethanes having amide units bearing a pendant functional group, where the nitrogen atom of the amide group is part of the polymer backbone. The pendant functional group of the functionalized amide polymer may be modified or added by post polymerization functionalization of the functionalized amide polymer. The pendant functional group of the functionalized amide polymer may include a protecting group that may be removed after polymerization. The pendant functional groups of the functionalized amide polymers may be used to modulate the physical, chemical and biological properties of the polymers.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: March 14, 2017
    Assignee: The University of Akron
    Inventors: Abraham Joy, Sachin Gokhale, Ying Xu
  • Patent number: 9469728
    Abstract: Disclosed herein are pH- and temperature-sensitive block copolymer with excellent safety and a method for preparing the same and a hydrogel and a drug carrier using the block copolymer. According to the present invention, the pH- and temperature-sensitive block copolymer comprises: obtained by copolymerization of: (a) polyethylene glycol-based compound (A); and (b) poly (?-amino ester)-based oligomer (B) or poly (amido amine)-based oligomer (C) or coupling of mixture (D) thereof. In order to control biodegradation rate, the block copolymer is mixed with poly (amido amine)-based oligomer instead of the poly (?-amino ester)-based oligomer and then coupling them.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: October 18, 2016
    Assignee: SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE
    Inventors: Doo Sung Lee, Minh Khanh Nguyen, Bong Sup Kim
  • Patent number: 9452143
    Abstract: The invention relates to matrix and layer compositions comprising a first polymer. The matrix and layer compositions are useful in the delivery of bioactives. In particular, the matrices and layers may have advantageous properties including mechanical properties and protection of bioactives and may also provide for pH-dependent release of a bioactive.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: September 27, 2016
    Assignee: NOVUS INTERNATIONAL, INC.
    Inventors: Houston Stephen Smith, Matthew J. Fischer, Graciela B. Arhancet, Rangarani Karnati, John A. Hume, Xiaojun Wang
  • Patent number: 9452377
    Abstract: A nanoporous ceramic membrane and preparation method thereof is provided. The nanoporous ceramic membrane is prepared by halloysite nanotubes (HNTs), and its porosity is between 35% to 85%. This method comprises steps as following: HNTs and polymers with a certain ratio are dispersed in organic solvent, and HNTs/polymer composite fibers are prepared through electrospinning method; after the HNTs/polymers composite fibers are laminated, they are sintered at high temperature in a certain or vacuum atmosphere, and a nanoporous ceramic membrane is obtained. Ceramic membrane prepared by this method is corrosion resistant, thermal resistant, and have large specific surface area, it may widely applied in the field of filtration, catalyst carrier and purification of high-temperature gas, etc.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: September 27, 2016
    Assignee: THE HKUST FOK YING TUNG RESEARCH INSTITUTE
    Inventors: Jingshen Wu, Dong Lv, Zheming Zhang, Dan Li
  • Patent number: 9410964
    Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: August 9, 2016
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
  • Patent number: 9395374
    Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: July 19, 2016
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
  • Patent number: 9370502
    Abstract: A composition comprising i) oligomeric lactic acid with the following formula (I) wherein n is an integer from 2 to 20, from 2 to 19, or from 2 to 18, and wherein from about 10 to about 20% w/w of the total weight of the oligomeric lactic acid is a trimer, HL3, having n equal to 2, wherein the number average molecular weight Mn of the oligomeric lactic acid is from about 200 to about 500, and ii) a mucoadhesive agent.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: June 21, 2016
    Assignee: LACCURE AB
    Inventors: Olov Sterner, Sören Kulstad, Jeanette Robertsson, Malgorzata Sznitowska, Werner Schubert
  • Patent number: 9308240
    Abstract: Insulin or a peroxisome proliferator-activated receptor (PPAR) agonist provides reliable and effective prevention of scarring in human skin, or at least a reduction in the severity of scarring. The application of insulin or the PPAR agonist to wounds topically or by local injection is particularly advantageous since it simultaneously reduces/prevents scarring while enhancing re-epithelialization of the wound and thus provides a dual action wound healing treatment. The present invention accordingly provides a highly effective prophylactic treatment for any individual suffering tissue trauma to reduce and/or prevent normal and/or pathological scarring.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: April 12, 2016
    Assignee: Pharmecosse Limited
    Inventors: Claire Linge, Ian Paul Mackie
  • Patent number: 9175114
    Abstract: Hair treatment compositions are disclosed comprising a ?-amino ester compound in a cosmetically acceptable vehicle, such as a spray or cream. In embodiments, the compounds include a polybutadiene moiety. Methods of treating hair with the compositions to impart volume, texture and definition are also disclosed.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: November 3, 2015
    Assignee: Living Proof, Inc.
    Inventors: David Thomas Puerta, Susan Alice Thiell, Ronald P. McLaughlin, Daniel Griffith Anderson
  • Patent number: 9150867
    Abstract: Materials and methods related to using multimeric DNA aptamers to treat demyelinating diseases are provided herein.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: October 6, 2015
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Louis J. Maher, III, Moses Rodriguez
  • Patent number: 9101666
    Abstract: Poly(?-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: August 11, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert S. Langer, David M. Lynn, David A. Putnam, Mansoor M. Amiji, Daniel Griffith Anderson
  • Publication number: 20150147399
    Abstract: The present invention provides a pharmaceutical composition formulated for oral delivery, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and a biologically active protein or peptide suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of a therapeutic protein or peptide.
    Type: Application
    Filed: December 9, 2014
    Publication date: May 28, 2015
    Inventors: Alexander Vol, Orna Gribova
  • Patent number: 9040034
    Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: May 26, 2015
    Assignees: International Business Machines Corporation, Agency for Science, Technology and Research
    Inventors: James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Yi Yan Yang
  • Publication number: 20150139935
    Abstract: Provided herein is technology relating to treating sleep apnea and particularly, but not exclusively, to treating sleep apnea with immunotherapeutics and/or anti-inflammatory drugs such as beta-interferons and glatiramer acetate.
    Type: Application
    Filed: June 14, 2013
    Publication date: May 21, 2015
    Applicant: The Regents of The University of Michigan
    Inventors: Tiffany J. Braley, Benjamin Segal, Ronald D. Chervin
  • Publication number: 20150132251
    Abstract: Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 14, 2015
    Inventors: Kazuro Lee Fujimoto, Jianjun Guan, Bradley B. Keller, Kimimasa Tobita, William R. Wagner
  • Patent number: 9028807
    Abstract: A method of forming a biocidal halogenated organic/inorganic composite material may include providing at least one inorganic precursor, providing at least one organic agent, precipitating an organic/inorganic composite material by contacting the at least one inorganic precursor with the at least one organic agent, and halogenating the organic/inorganic composite material by contacting the organic/inorganic composite material with a halogen. Also, a halogenated organic/inorganic composite material may include an inorganic composition comprising a metal oxide and a halogenated organic composition. The inorganic composition and the halogenated organic composition are dispersed throughout the composite material.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 12, 2015
    Assignee: UES, Inc.
    Inventors: Matthew B. Dickerson, Rajesh R. Naik
  • Patent number: 9017644
    Abstract: The present invention relates to dendrimer compositions configured for treating inflammatory disorders and autoimmune disorders, and related methods of synthesis. Specifically, the present invention relates to methods for treating rheumatoid arthritis with PAMAM dendrimers having functional ligands configured for treating rheumatoid arthritis (e.g., therapeutic agents, pro-drugs, targeting agents, trigger agents, imaging agents) (e.g., methotrexate).
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: April 28, 2015
    Assignee: The Regents of the University of Michigan
    Inventors: James R. Baker, Jr., Larry A. Sternson, David Repp, Deborah Ladenheim
  • Publication number: 20150110733
    Abstract: The present invention provides a method for treating a human subject afflicted with multiple sclerosis or a single clinical attack consistent with multiple sclerosis with a pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier, comprising the steps of: (i) determining a genotype of the subject at a location corresponding to the location of one or more single nucleotide polymorphisms (SNPs) selected from the group consisting of: Group 1, (ii) identifying the subject as a predicted responder to glatiramer acetate if the genotype of the subject contains one or more A alleles at the location of Group 2, one or more C alleles at the location of Group 3, one or more G alleles at the location of Group 4, or one or more T alleles at the location of kgp18432055, kgp279772, kgp3991733 or kgp7242489; and (iii) administering the pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier to the subject only if the subject is identif
    Type: Application
    Filed: October 21, 2014
    Publication date: April 23, 2015
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Amir TCHELET, Michael HAYDEN, Liat HAYARDENY, Colin James Douglas ROSS, Iris GROSSMAN, David LADKANI
  • Patent number: 8999302
    Abstract: Embodiments of a skin dye protectant formulation comprise at least about 30% by weight of a film forming composition, at least about 40% by weight of a solvent, water, at least 0.1% by weight of a dye, and at least about 1% to about 5% of antioxidants, wherein the formulation is operable to substantially maintain the color of the dye when the skin dye protectant formulation is subjected to gamma sterilization.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: April 7, 2015
    Assignee: Aplicare, Inc.
    Inventor: David Alan Childers
  • Publication number: 20150093353
    Abstract: Biomaterial compositions comprising extracellular matrix (ECM) and an ECM-mimicking biomaterial, such as poly(glycerol sebacate) (PGS), for treating damaged biological tissue; particularly, damaged cardiovascular tissue. The biomaterial compositions can also include additional biologically active agents, such as growth factors, and polymeric materials, such as polyepsilon-caprolactone (PCL).
    Type: Application
    Filed: December 10, 2014
    Publication date: April 2, 2015
    Inventor: Robert G. Matheny
  • Patent number: 8992945
    Abstract: A bio-adhesive supramacromolecular complex of the general formula: wherein R1 is independently selected from the group consisting of an alkane unsubstituted or substituted with alkoxy groups; R2 is independently selected from the group consisting of C1-6 alkyl; R3 and R4 are independently selected from the group consisting of optionally substituted aliphatic or aromatic alkyl; R5 is independently selected from the group consisting of H or C1-6 alkyl; W is a hydrogen-bond accepting functional group-containing entity; Y is a carboxylic acid ester or amide linkage; R is an independently selected peptide linking group; T1, T2, T3 and T4 are independently selected polymer residues; and m1, m2, m3, n1 and n2 are integers selected from at least 25; and wherein P has a molecular weight of about 1×103 to 1×107 and Q has a molecular weight of about 1×103 to 1×107. The complex provides controlled nitric oxide release over a longer period of time than prior art compounds in the locally delivery systems.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: March 31, 2015
    Assignee: University of Toronto
    Inventors: Ping I. Lee, Yan Li
  • Publication number: 20150086504
    Abstract: The invention provides novel self-emulsifying diblock copolymers and novel self-emulsifying compositions comprising an active ingredient and a diblock copolymer characterized in that the diblock copolymer is liquid at a temperature below 50° C. and the composition is non-aqueous and liquid at a temperature below 50° C.
    Type: Application
    Filed: December 1, 2014
    Publication date: March 26, 2015
    Inventors: Albertina Maria Eduarda Ariën, Marcus Eli Brewster, Aruna Nathan, Joel Rosenblatt, Louisa Myriam Ould-Ouali, Véronique Préat
  • Patent number: 8986724
    Abstract: Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: March 24, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Thierry Glauser, Stephen D. Pacetti, Paul M. Consigny
  • Publication number: 20150079151
    Abstract: A composition comprising the reaction product of (a) an isocyanate group-containing component having an average functionality of at least 2; and (b) an active hydrogen group-containing component having an average functionality of at least 2. The composition is biodegradable, a solid at 22° C. and below, and has pressure sensitive adhesive properties at a temperature of 37° C. and relative humidity of 100%. The composition may be used to adhere polymer meshes or films to biological tissue.
    Type: Application
    Filed: November 24, 2014
    Publication date: March 19, 2015
    Inventors: Eric J. Beckman, Jessica L. Meyers
  • Publication number: 20150079147
    Abstract: A fiber wadding for filling bone defects having a flocculent three-dimensional structure is disclosed. The fiber wadding includes a plurality of fibers that contain a biodegradable resin as a principal component and a siloxane. Outside diameter of the plurality of fibers of the wadding is from about 0.05 ?m to about 30 ?m. Bulk density of the fiber wadding is about 0.005-0.3 g/cm3.
    Type: Application
    Filed: September 24, 2014
    Publication date: March 19, 2015
    Inventors: Toshihiro Kasuga, Akiko Obata, Kie Fujikura, Yoshio Ota, Xianfeng Yao
  • Patent number: 8962676
    Abstract: The present invention is directed to the treatment of demyelination as an underlying cause of the disease of multiple sclerosis (MS) in a mammal, the method comprising promoting remyelination of myelination of axonal cells by administering to the mammal a 2-oxopyrrolidine compound having a general formula I: wherein R?R??H, and R??CH2CONH-(2,6CH3)C6H3 or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: February 24, 2015
    Assignee: University College Dublin, National University of Ireland, Dublin
    Inventors: Mark Pickering, Keith Murphy
  • Patent number: 8961949
    Abstract: The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor-specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood. The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).
    Type: Grant
    Filed: June 26, 2009
    Date of Patent: February 24, 2015
    Assignee: Japan Science and Technology Agency
    Inventors: Kazunori Kataoka, Sachiko Kaida, Horacio Cabral, Michiaki Kumagai, Masaki Sekino
  • Patent number: 8945610
    Abstract: The invention relates to a condensation product obtainable by reaction of a1) at least one bicyclic or polycyclic aromatic or heteroaromatic, where the bicyclic or polycyclic aromatic or heteroaromatic is substituted by at least one carboxyl group (—COOH), and where the carboxyl group can be present in salt form, a2) at least one carbonyl compound, a3) if appropriate at least one sulfonating agent, a4) at least one urea derivative, and a5) if appropriate at least one further aromatic or heteroaromatic, or a physiologically tolerable salt thereof.
    Type: Grant
    Filed: November 11, 2008
    Date of Patent: February 3, 2015
    Assignee: BASF SE
    Inventors: Sebastien Garnier, Stephan Hüffer, Günter Scherr, Joachim Roser, Ulrich Mrowietz, Hans Wilhelm Doerr, Jindrich Cinatl, Martin Michaelis
  • Publication number: 20150030560
    Abstract: The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.
    Type: Application
    Filed: February 24, 2014
    Publication date: January 29, 2015
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Rina Aharoni, Dvora Teitelbaum, Ruth Arnon, Michael Sela, Masha Fridkis-Hareli, Jack L. Strominger
  • Publication number: 20150024031
    Abstract: Disclosed herein are methods and pharmaceutical compositions for reducing the pain associated with parenterally administering a therapeutic agent. The methods and compositions comprise a dispersion comprising microparticles of an analgesic agent in an amount effective to reduce the pain, inflammation, and/or immunological reaction associated with parenterally administering a primary therapeutic agent, wherein the microparticles of the analgesic agent have an effective particle size of less than 20 micrometers.
    Type: Application
    Filed: July 16, 2014
    Publication date: January 22, 2015
    Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA
    Inventors: Barrett Rabinow, Jane O. Werling
  • Publication number: 20150017117
    Abstract: The present invention relates to a biocompatible polymer composition, suitable for in vivo vessel repair, comprising a matrix pre-polymer, a filler and a curing agent, wherein said composition wherein said biocompatible polymer composition is curable in the presence of a curing catalyst at 37° C. to form a cured material with an elongation until rupture of at least 5% and an elastic modulus of at least 1 MPa.
    Type: Application
    Filed: December 7, 2012
    Publication date: January 15, 2015
    Inventor: Alexander Cornelis de Vries
  • Publication number: 20150017115
    Abstract: Polymeric conjugates of a polymeric backbone formed of a plurality of backbone units and having attached to portions of the backbone units two or more therapeutically active agents, or one or more therapeutically active agents and a NCAM targeting moiety, are disclosed. Uses of such polymeric conjugates in treating and/or monitoring cancer and/or medical conditions associated with angiogenesis are also disclosed.
    Type: Application
    Filed: March 5, 2013
    Publication date: January 15, 2015
    Inventors: Ronit Satchi-Fainaro, Ela Markovsky, Hemda Baabur-Cohen
  • Patent number: 8932611
    Abstract: The present invention relates to a solid anhydrous cosmetic composition comprising at least one non-spherical silicone elastomer and at least one silicone elastomer powder coated with a silicone resin. The invention also relates to a makeup process comprising the application to keratin materials of the said composition, and also to its use for obtaining a uniform makeup result that shows good fastness of the color over time.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: January 13, 2015
    Assignee: L'Oreal
    Inventors: Agnès Themens, Maïtena Leuridan
  • Publication number: 20150010631
    Abstract: The current invention involves the administration of negatively charged particles, such as polystyrene, PLGA, or diamond particles, to subjects to ameliorate inflammatory immune responses. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same negatively charged particles.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 8, 2015
    Applicant: Cour Pharmaceuticals Development Company
    Inventor: Daniel GETTS
  • Publication number: 20150010492
    Abstract: The invention relates to methods of inhibiting biofilm formation or reducing biofilms in a subject or on a device or surface by administering a charged compound such as a polyamino acid to a subject, device or surface. The invention also relates to compositions for inhibiting biofilm formation or reducing biofilms.
    Type: Application
    Filed: May 1, 2014
    Publication date: January 8, 2015
    Applicant: National Jewish Health
    Inventors: Jerry A. Nick, Quinn M. Parks
  • Patent number: 8926955
    Abstract: The present invention relates to a process for the preparation of polymer conjugates of indolocarbaxole compounds, in particular of polymer conjugates of K-252a and derivatives thereof, by a synthetic route which results in a highly pure product, with a high product yield. In a further aspect the present invention relates to novel polymer conjugates of K-252a and derivatives thereof, wherein the chemical group linking the polymer unity to the K-252a or to the K-252a derivative compound is characterized by a 5-member oxazolidindionic cyclic structure. These novel polymer conjugates are obtained through the novel synthetic route with high purity and high yields.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: January 6, 2015
    Assignee: Creabilis S.A.
    Inventors: Raffaella Bagnod, Luca Beccaria, Luisa Bertarione Rava Rossa, Domenico Criscuolo, Chiara Lorenzetto, Valentina Mainero, Alessandra Marconi, Carlo Pincelli, Silvio Traversa
  • Patent number: 8921448
    Abstract: A low toxicity, highly efficient transfection composition is described with an amphipathic compound containing at least one imidazole. The composition may be used in the process of transfecting nucleic acids into an animal cell.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: December 30, 2014
    Assignee: Mirus Bio LLC
    Inventors: Shannon E. Bruse, Laura K Juckem, Karen M Neder
  • Patent number: 8920789
    Abstract: The invention provides method for sequestering or trapping L-lactate in or near a tumor cell comprising contacting an isolated polymer of D-lactic acid (PDLA) or an equivalent, derivative or analog thereof with the tumor cell so that the PDLA binds L-lactate in or near the cell and thereby sequestering or trapping L-lactate in or near the tumor cells.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: December 30, 2014
    Assignee: The United States of America as represented by the Department of Veterans Affairs
    Inventors: Joel S. Goldberg, Joe Brice Weinberg