Oxygen Heterocycle Patents (Class 424/78.38)
  • Patent number: 11530302
    Abstract: The present invention concerns a method to prepare a filler with a hyaluronic acid, which has improved properties of chemical-physical stability over time and optimal viscosity for cutaneous injection. In particular the method comprises a first step in which the hyaluronic acid is crosslinked, and a subsequent step for the neutralization and hydration of the crosslinked hyaluronic acid.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: December 20, 2022
    Assignee: MATEX LAB S.P.A.
    Inventor: Nicola Zerbinati
  • Patent number: 11447602
    Abstract: A biodegradable triblock copolymer comprising: an A-B-A? structure wherein the A and A? blocks each include polylactide, the B block includes from about 55 to about 100 mole percent of polytrimethylene carbonate and 0 to about 45 mole percent polylactide, and the biodegradable triblock copolymer overall includes from about 15 to about 25 mole percent of the polytrimethylene carbonate and from about 75 to about 85 mole percent of the polylactide. Also provided are compositions and implantable medical devices made therefrom.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: September 20, 2022
    Assignees: SOFRADIM PRODUCTION, COVIDIEN LP
    Inventors: Walter Skalla, Jonathan Thomas, Thierry Brune, Darlene P. Nebinger, Seth S. Gleiman, Robert Vestberg
  • Patent number: 11172675
    Abstract: A nano lipid delivery system is provided, more particularly, a nano concentrate, a nano-lipid stable emulsion, a method of preparing a nano lipid concentrate and lipid delivery system for use as a carrier for industrial, medical, animal, horticultural and agricultural chemistries.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: November 16, 2021
    Assignee: ORO AGRI INC.
    Inventors: Paulo Sergio Berg, Melvin Donovan Pullen
  • Patent number: 10988489
    Abstract: Disclosed are novel organoborane compositions of Formula (I), (II) or (III), wherein R1, R2, R3, R?, R?, n, n?, n?, m, m?, and m? are defined hereinabove. Also disclosed is a method of using said compositions for electrolytic media in lithium rechargeable batteries, including lithium-ion or lithium-air rechargeable batteries. Also disclosed are compositions containing said Formula (I), (II) and (III) compounds with lithium salts, useful as electrolytic media or matrices.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: April 27, 2021
    Assignee: Clark Atlanta University
    Inventors: Ishrat Khan, Ahmed Alzharani, Amal Al-abdulrahman, Rasha Alshahrani
  • Patent number: 10835578
    Abstract: The present invention relates to a CNP prodrug or a pharmaceutically acceptable salt thereof comprising a CNP moiety -D; and a carrier moiety —Z that is conjugated through a moiety -L2- to a reversible prodrug linker moiety -L1-, which reversible prodrug linker moiety -L1- is covalently and reversibly conjugated to -D; wherein -L2- is a chemical bond or a spacer; and —Z is a polymer having a molecular weight of at least 10 kDa. It further relates to pharmaceutical compositions comprising the CNP prodrug or a pharmaceutically acceptable salt thereof, their use as a medicament and to methods of treatment.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: November 17, 2020
    Assignee: ASCENDIS PHARMA GROWTH DISORDERS A/S
    Inventors: Harald Rau, Ulrich Hersel, Felix Cleemann, Caroline Elisabeth Rasmussen
  • Patent number: 10781285
    Abstract: The present invention relates to an improved method for preparing a high purity polyethylene glycol dialdehyde derivative. The preparation method can provide the polyethylene glycol dialdehyde derivative suitable as a raw material for pharmaceuticals because of high purity and terminal activity, by using PEG-diacetal, which is prepared by reacting polyethyleneglycol methanesulfonate with dialkoxy-1-propanol, as an intermediate.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: September 22, 2020
    Assignee: Hanmi Fine Chemical Co., Ltd.
    Inventors: Yu Rim Kim, Eun Rang Park, Bo Sung Kwon, Young Bum Cho, Jun Ho Chu
  • Patent number: 10266512
    Abstract: Processes for preparing heteroatom containing cyclic dimers that result in increased production efficiency and reduced waste production.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: April 23, 2019
    Assignee: Novus International, Inc.
    Inventors: Xiaojun Wang, Mark A. Hochwalt, Graciela B. Arhancet
  • Patent number: 10092658
    Abstract: A transdermal delivery system of drug and a method of preparing the same are provided. More specifically, the invention can be a transdermal delivery system applied for various protein drugs such as vaccines and chemical drugs, because the drug delivery system has a biocompatibility, biodegradation property, transdermal delivery property, the safety of human body, maximum activity of protein drugs, good bio-conjugation efficiency and a long-term efficacy, a method of preparing the same and its use.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: October 9, 2018
    Assignee: PHI BIOMED CO., LTD.
    Inventors: Sei Kwang Hahn, Eung-Sam Kim, Jeonga Yang, Hyemin Kim, Kwan Yong Choi, Ji Hye Shin, Jung-Hee Kwon
  • Patent number: 9895465
    Abstract: The present invention is direct to a body-absorbable, mechanically hemostatic composition comprising a solid poloxamer having an average molecular weight of about 7,000 g/mol to about 15,000 g/mol, a high molecular weight dextran, optionally a fatty acid salt, and water, and a method for mechanically controlling the bleeding of bone comprising applying an effective amount of the composition to the affected area.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: February 20, 2018
    Assignee: Pioneer Surgical Technology, Inc.
    Inventors: Francis Vincent Lamberti, Barbara Sage
  • Patent number: 9492590
    Abstract: A biocompatible material comprising a resorbable polymer matrix and at least one additive, wherein the resorbable polymer matrix comprises: (i) at least one non-random copolymer of poly (alkylene oxide) s, and (ii) at least one poly (alkylene glycol) polymer and/or at least one methoxypoly (alkylene glycol) polymer, and wherein the at least one additive is selected from solid particles, porous particles, hollow particles, polymers, inert fillers, bioactive compounds, color pigments and combinations of two or more thereof.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: November 15, 2016
    Assignee: ApaTech Limited
    Inventors: Qian Cai, Mervyn Little, Thomas Buckland
  • Patent number: 9486478
    Abstract: Compositions are provided for preferential distribution of active agents to injury sites. Such compositions may comprise a ligand with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature so that binding of the active agent to the delivery ligand and release of the active agent into the target site are not dependent on enzymatic activity. Methods of using such compositions are also disclosed.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: November 8, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, Toya Kimble
  • Patent number: 9452183
    Abstract: Methods of treating hemorrhage are provided, comprising diagnosing one or more hemorrhaging or potentially hemorrhaging vessels in a patient and administering to the patient a therapeutically effective amount of a composition comprising a vessel closing compound at a concentration between about 0.1% and about 45%. The vessel closing compound may comprise a polymer with hydrophilic properties, such as polyethylene glycol (PEG). The composition may also comprise one or more active agent such as a blood flow modifier with a potential to form ionic bonds with the vessel closing agent.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: September 27, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Josee Roy
  • Patent number: 9364549
    Abstract: A method for manufacturing a drug-delivery composition includes providing at least a pharmaceutically active composition, providing a hydrophobic matrix; and mixing the hydrophobic matrix and the pharmaceutically active composition to form a paste-like or semi-solid drug-delivery composition.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: June 14, 2016
    Inventors: Andreas Voigt, Jörg Kriwanek, Scott Hampton, Andreas Reiff, Sonja Ludwig
  • Patent number: 9211317
    Abstract: In the field of biological medicines, a use of prourokinase (proUK) and variants thereof in facilitated percutaneous coronary intervention (PCI) in patients with acute myocardial infarction is provided. The use includes: within 6 hrs after a patient is afflicted with accurate myocardial infarction (AMI), firstly, performing thrombolytic therapy with proUK or variants thereof, and then, performing a PCI operation, to dredge the infarction related artery (IRA) as soon as possible, and re-establish an effective forward blood flow, such that an ischemic myocardium is reperfused. According to the present invention, the facilitated PCI for treatment of AMI with the proUK or variants thereof has an effect superior to that of direct PCI.
    Type: Grant
    Filed: April 1, 2008
    Date of Patent: December 15, 2015
    Inventor: Jianning Liu
  • Patent number: 9155758
    Abstract: The invention provides a method for treating or preventing heart failure in a subject, which includes administering to the subject in need thereof a therapeutically effective amount of a Poloxamer (e.g., Poloxamer 188).
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: October 13, 2015
    Assignee: PHRIXUS PHARMACEUTICALS, INC.
    Inventor: Bruce Edward Markham
  • Patent number: 9011832
    Abstract: The present invention provides cyclic dimers of alpha acids and polymers derived therefrom. Also provided are processes for preparing and methods of using the cyclic dimers and the polymers derived from the cyclic dimers.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: April 21, 2015
    Assignee: Novus International, Inc.
    Inventors: Graciela B. Arhancet, Matthew Mahoney, Xiaojun Wang
  • Patent number: 8940286
    Abstract: A method and evaluation kit are provided, in which a high-capacity urate transporter is identified to assist in the early treatment and prevention of urate transport-related disease and inflammation-related disease. The method can include a step for detecting variations in genes that encode ABCG2 protein. When a subject has an SNP of V12M, R113X, Q126X, Q141K, F208S, G268R, E334X, S441N, L447V, S486N, F506SfsX4, R575X, and/or C608X, it can be concluded that the subject has a factor that is capable of inducing urate transport failure, or a state or disease attributable to that failure. When a subject has an SNP of V12M, it can be concluded that, unlike the other SNPs, there is a possibility that the subject does not possess such a factor because, although this variation itself does not lead to a change in urate transport capability, said variation is related to linkage disequilibrium with other SNPs.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: January 27, 2015
    Assignees: The University of Tokyo, Tokyo University of Pharmacy and Life Sciences
    Inventors: Hirotaka Matsuo, Nariyoshi Shinomiya, Takahiro Nakamura, Tappei Takada, Hiroshi Suzuki, Yuki Ikebuchi, Kousei Ito, Kimiyoshi Ichida
  • Publication number: 20150023905
    Abstract: A biocompatible, polymeric composition is disclosed. The composition comprises a base polymer comprising (i) a prepolymer comprising para-dioxanone (PDO) and trimethylene carbonate (TMC); and (ii) an end-graft polymer chain comprising a polylactone. Also disclosed are a method for treating bleeding from bone or bony structures using the composition, a method for filling a void or correct a defect in a bone using the composition, and a method for producing the biocompatible, polymeric composition of the present application.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 22, 2015
    Applicant: Poly-Med, Inc.
    Inventors: Kenneth David Gray, Michael Scott Taylor
  • Publication number: 20150004206
    Abstract: The invention relates to a process for preparing PCL-comprising microparticles, to microparticles obtainable by said process, to gel hence obtained and to several uses of the gel such as for the preparation of a medicament for treating a skin abnormality or disfigurement, and/or for controlling bladder function and/or controlling gastric reflux and/or for treating erectile dysfunction and/or for treating vocal cords. The gel may also be used for cosmetic applications.
    Type: Application
    Filed: July 1, 2014
    Publication date: January 1, 2015
    Inventors: Henderikus Supèr, Paul Willem Mijnen, Pieter Gerard Zijlstra, Dirk Wybe Grijpma
  • Publication number: 20140377213
    Abstract: A cell growth matrix is provided that comprises a biodegradable elastomeric polymer electrodeposited concurrently with a sprayed or electrosprayed liquid that is a physiological solution or which comprises a mammalian blood product such as serum, plasma or platelet rich plasma. The matrix is useful as a cell-growth matrix and for repair of a tissue in a mammal, for instance by implantation in a mammal at a site in need of repair, such as in an abdominal wall.
    Type: Application
    Filed: May 27, 2011
    Publication date: December 25, 2014
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Yi Hong, Nicholas J. Amoroso, Kazuro Lee Fujimoto, Ryotaro Hashizume, Michael Steven Sacks, William R. Wagner
  • Publication number: 20140314705
    Abstract: The present specification generally relates to compositions comprising a thermoresponsive polymer and methods of treating a soft tissue condition using such compositions.
    Type: Application
    Filed: July 3, 2014
    Publication date: October 23, 2014
    Inventors: Scott Whitcup, Orest Olejnik
  • Patent number: 8865151
    Abstract: Described herein are MetAP-2 inhibitors and compositions and formulations thereof, and more particularly compositions and formulations of MetAP-2 inhibitors wherein the MetAP-2 inhibitor is associated with a block copolymer comprising a hydrophilic polymer moiety and a hydrophobic polymer moiety. The present invention also relates to compositions and formulations comprising MetAP-2 inhibitors for oral administration or administration via routes such as topical or ocular administration. The present invention also provides methods to treat conditions associated with or related to the over-expression or over-activity of MetAP-2 by administering the compositions and formulations comprising MetAP-2 inhibitors as disclosed herein.
    Type: Grant
    Filed: December 28, 2009
    Date of Patent: October 21, 2014
    Assignee: Children's Medical Center Corporation
    Inventors: Ofra Benny-Ratsaby, Robert D'Amato, Judah Folkman
  • Patent number: 8846022
    Abstract: One aspect of the present invention relates to methods of sealing a wound or tissue plane or filling a void space, or securing meshes, films or other devices within the body. In certain embodiments, the wound is an ophthalmic, pleural or dural wound, or a hernia repair mesh. Remarkably, disclosed herein is the discovery that the use of certain crosslinkers in combination with polyalkyleneimines at specific concentrations can result in hydrogels with tunable degradation properties.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: September 30, 2014
    Assignee: HyperBranch Medical Technology, Inc.
    Inventors: Michael A. Carnahan, Jared Daniel Goodnow Butlin
  • Publication number: 20140271533
    Abstract: Systems and methods related to polymer foams for the treatment of blood vessel dissections are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to or within a dissection caused by an intimal tear in a blood vessel, sealing the dissection and preventing further perfusion thereof. In some embodiments, the polymer foam can be formed within a body cavity (i.e., in-situ foam formation). The foam may be used to fill the dissection as a thrombosing agent. In addition, the foam may be used in conjunction with medical devices such as stents, stent-grafts, balloons, and catheters.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Inventors: Toby Freyman, Meghan McGill
  • Publication number: 20140271528
    Abstract: Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Medicus Biosciences LLC
    Inventors: Syed H. ASKARI, Yeon S. CHOI, Paul YuJen WAN
  • Patent number: 8835556
    Abstract: The present invention is directed to conjugates of hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: September 16, 2014
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Publication number: 20140255458
    Abstract: According to an aspect of the invention, injectable bulking compositions are provided which contain the following: (a) fibers that are configured to prevent migration to locations in the body remote from the injection site, for example, because they have a minimum length that is sufficiently large to prevent migration of the fibers and/or because they have surface features that stimulate host tissue response to lock the fibers in position and (b) a carrier in an amount effective to render the composition injectable.
    Type: Application
    Filed: May 20, 2014
    Publication date: September 11, 2014
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Jianmin Li, Michael Madden
  • Patent number: 8828373
    Abstract: A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn?1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: September 9, 2014
    Assignee: NOF Corporation
    Inventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
  • Patent number: 8815227
    Abstract: The present invention provides, among other things, polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains and a plurality of hydroxyapatite-targeting moieties, and optionally the reagents include one or more degradable linkages that serve to divide the polymer chains into polymer segments having a molecular weight suitable for renal clearance.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: August 26, 2014
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski
  • Patent number: 8802147
    Abstract: The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: August 12, 2014
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Patent number: 8795730
    Abstract: Compositions are provided for promoting healing of tissue of a vertebrate organism. The compositions can be for internal administration of a therapeutically effective amount of pharmacologically active, protease inhibiting, aqueous media soluble polysulfonated materials in salt form and associated with a secondary material to reduce one or more of inflammation, bacterial proliferation, proteolytic activity, and cancerous cell growth. The compositions may additionally or alternatively be cross-linked so as to alter the solubility of these pharmacologically active salts or slow dissolution by providing biodegradable cross-linkers. Compositions for healing the tissue of a multicellular organism are provided that can include a polysulfonated material in a liquid mixture, as solid particles or constructs that may or may not biodegrade or deliver a pharmacologically relevant value.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: August 5, 2014
    Inventor: David John Vachon
  • Publication number: 20140212372
    Abstract: Novel, crosslinked polymers using biomass derived materials, such as aldaric acids and derivatives, are provided. The polymers can be used as hydrogels and in antimicrobial compositions.
    Type: Application
    Filed: December 4, 2013
    Publication date: July 31, 2014
    Applicant: E I DU PONT DE DEMOURS AND COMPANY
    Inventors: MARK ALLEN ANDREWS, Garret D. Figuly, Henry Keith Chenault
  • Patent number: 8790634
    Abstract: The present invention provides methods to treating inflammation related disease and disorders such as an autoimmune disease and autoimmune related uveitis by administering compositions and formulations comprising MetAP-2 inhibitors as disclosed herein. The composition comprises a formulation of a fumagillol derivative that retains anti-inflammation activity and is associated with a block copolymer comprising a hydrophilic polymer moiety and a hydrophobic polymer moiety.
    Type: Grant
    Filed: December 28, 2009
    Date of Patent: July 29, 2014
    Assignee: Children's Medical Center Corporation
    Inventors: Ofra Benny-Ratsaby, Robert D'Amato, Takeru Yoshimura
  • Patent number: 8778326
    Abstract: A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized polysaccharide containing pendant aldehyde groups with a water-dispersible, multi-arm amine is described. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a more rapid degradation time, such as the prevention of undesired tissue-to tissue adhesions resulting from trauma or surgery.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: July 15, 2014
    Assignee: Actamax Surgical Materials, LLC
    Inventors: Helen S. M. Lu, Steven W. Shuey
  • Publication number: 20140178328
    Abstract: A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.
    Type: Application
    Filed: February 28, 2014
    Publication date: June 26, 2014
    Applicant: 206 ORTHO, Inc.
    Inventors: Jeffrey A. D'Agostino, Andrew J. Carter, Craig M. Jones, Arthur C. Watterson
  • Publication number: 20140147472
    Abstract: Provided is a bioadhesive composition and device including same, the composition including a polymeric matrix and at least one synthetic bioadhesive polymer carried by the polymeric matrix, the polymeric matrix including at least one synthetic thermoplastic polymer characterized by one or more of (a) an average molecular weight in the range of between 20,000 Da to 90,000 Da; and (b) it includes polycaprolactone (PCL); wherein exposure to heat causes the bioadhesive composition to transform into a non-solid state and to cohesively adhere to a biological tissue upon subsequent cooling thereof. Also provided herein are methods of preparing the composition or device, and use of the composition or device in therapy, e.g. for treating hernia.
    Type: Application
    Filed: September 27, 2011
    Publication date: May 29, 2014
    Applicant: MEDIZN TECHNOLOGIES LTD.
    Inventors: Nissan Elimelech, Ana Dotan, Amos Ophir
  • Patent number: 8722032
    Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: May 13, 2014
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Patent number: 8722579
    Abstract: An aqueous composition for treatment of water comprising: (a) an N,N-dimethyl-2-hydroxypropylammonium chloride polymer; (b) lanthanum chloride; and (c) a dimethylamine epichlorohydrin ethylenediamine polymer; and a method of treating water using the composition.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: May 13, 2014
    Assignee: Waterco Limited
    Inventors: Robert Ian Anderson, Paul Seidl
  • Patent number: 8703893
    Abstract: A polymeric dendrimer-like structure with four branches of monomethoxy-polyethylene glycol that can be represented as: The carboxylic group of the previous structure can be functionalized for the production of conjugates of pharmaceutical interest. The binding of this dendrimer-like polyethylene glycol to therapeutic proteins improves their in vitro and in vivo stability.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: April 22, 2014
    Assignee: Centro de Ingenienia Genetica y Biotecnologia
    Inventors: José Ángel Ramón Hernández, Fidel Raúl Castro Odio, Vivian-María Sáez Martinez, Rolando Páez Meircles, Eduardo Fernández Sánchez
  • Patent number: 8703293
    Abstract: Provided herein re a composition and a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: April 22, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Connie S. Kwok
  • Publication number: 20140105852
    Abstract: A process for making cross-linked polysaccharide gels, particularly cross-linked hyaluronic acid gels, under basic conditions. The resulting gels possess improved degradation characteristics, and are useful in a variety of medical and cosmetic applications.
    Type: Application
    Filed: December 26, 2013
    Publication date: April 17, 2014
    Applicant: Ultraceuticals R&D Pty. Limited
    Inventors: Simone Charlotte Vonwiller, Geoffrey Kenneth Heber
  • Publication number: 20140105851
    Abstract: Disclosed herein are novel compositions and methods for treating or preventing GI tract disorders and/or GERD-related respiratory disorders as well as protecting stratified squamous epithelium against injury by a noxious substance. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor, and optionally one or more agent chosen from antacids, histamine H2-receptor antagonists, ?-aminobutyricacid-b (GABA-B) agonists, prodrugs of GABA-B agonists, and protease inhibitors.
    Type: Application
    Filed: October 14, 2013
    Publication date: April 17, 2014
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventor: Mark G. CURRIE
  • Patent number: 8697045
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: April 15, 2014
    Assignee: Merck Sharp & Dohme Corporation
    Inventors: Seoju Lee, David C. Wylie, Susan Cannon-Carlson
  • Publication number: 20140099370
    Abstract: The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.
    Type: Application
    Filed: September 24, 2013
    Publication date: April 10, 2014
    Applicant: BEZWADA BIOMEDICAL, LLC
    Inventor: Rao S Bezwada
  • Publication number: 20140086866
    Abstract: In one aspect, methods for separating biological tissue are described herein. In some embodiments, a method for separating tissue comprises providing a first composition comprising a polymerizable material, providing a second composition comprising a polymerization initiator, disposing the first composition at a first site beneath a first tissue layer, disposing the second composition at the first site, polymerizing the polymerizable material at the first site, and separating the first tissue layer from a second tissue layer.
    Type: Application
    Filed: November 20, 2013
    Publication date: March 27, 2014
    Applicant: Board Of Regents, The University of Texas System
    Inventors: Jian Yang, Minh-Tuan Richard Tran, Michael W. Palmer, Shou-Jiang Tang
  • Patent number: 8679536
    Abstract: Adhesives formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. The use of the adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; and drug delivery are described. The adhesive may also be used for industrial and consumer applications.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: March 25, 2014
    Assignee: Actamax Surgical Materials, LLC
    Inventor: Samuel David Arthur
  • Patent number: 8679537
    Abstract: Methods for sealing an orifice in tissue in the body of a living animal using an adhesive formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. Methods for using the adhesive for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; and drug delivery are described.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: March 25, 2014
    Assignee: Actamaz Surgical Materials, LLC
    Inventor: Samuel David Arthur
  • Publication number: 20140079759
    Abstract: Fibrous polymer scaffolds having at least one layer of diametrically patterned fibers, as well as methods of manufacture, are provided. The scaffolds can be formed of multiple layers and the extent and direction of alignment of each layer can be controlled. Fabrication systems and methods for producing such scaffolds including apparatuses and processes are also provided.
    Type: Application
    Filed: December 2, 2011
    Publication date: March 20, 2014
    Applicant: NanoNerve, Inc
    Inventors: Shyam Patel, Kyle Kurpinski
  • Patent number: 8673287
    Abstract: It is intended to provide a composition having an excellent anti-obesity action without potential for adverse side effects and the like even if taken for a long period of time. The composition is an anti-obesity composition containing an acacia bark derivative.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: March 18, 2014
    Assignee: Mimozax Co., Ltd.
    Inventors: Yusho Nakamoto, Keiko Ono
  • Publication number: 20140044671
    Abstract: Disclosed is a polymer or physiologically acceptable salt thereof. The polymer comprises a polymerized multifunctional amine monomer. The amine monomer comprises at least two amine groups and at least two acyclic nitrogen atoms that are connected through a —CH2CH2— group, provided that the amine monomer is not ethylenediamine or diethylenetriamine. The disclosed polymers can be used to bind anions in subject in need of such treatment.
    Type: Application
    Filed: October 17, 2013
    Publication date: February 13, 2014
    Applicant: Genzyme Corporation
    Inventors: Chad C. Huval, Pradeep Dhal, S. Randall Holmes-Farley