Monomer Contains Oxygen Patents (Class 424/78.37)
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Publication number: 20120040002Abstract: Biocompatible and resorbable melt derived glass compositions which include: SiO2 60-70 weight-%, Na2O 5-20 weight-%, CaO 5-25 weight-%, MgO 0-10 weight-%, P2O5 0.5-3.0 weight-%, B2O3 0-15 weight-%, Al2O3 0-5 weight-%, and which contain less than 0.05 weight-% potassium. Biocompatible and resorbable glass fibres manufactured from these glass compositions, medical devices containing fibres of the invention, the use of these compositions for the manufacture of glass fibre and the use of the fibres for the manufacture of medical devices are also disclosed.Type: ApplicationFiled: April 20, 2010Publication date: February 16, 2012Inventors: Timo Lehtonen, Jukka Tuominen, Fredrik Ollila
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Publication number: 20120027715Abstract: The disclosure relates to polymer films containing iodinated resin, where such films have advantageous antibacterial and/or antitoxic properties. The films may be used, for example, in medical tape, wound dressings and bandages. In certain embodiments, the invention is also directed to methods of manufacturing such polymer films, where various manufacturing difficulties have been addressed and overcome.Type: ApplicationFiled: August 1, 2011Publication date: February 2, 2012Applicant: TRIOMED INNOVATIONS CORP.Inventors: Pierre J. Messier, David Ohayon
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Publication number: 20120027719Abstract: A method of making an aliphatic polyester prepolymer, comprising: reacting, alone or in combination with other reactants, a diol with at least a first diacid (or a diester of said first diacid) to produce an aliphatic polyester prepolymer. The first diacid is preferably a trans-beta-hydromuconic acid (HMA). In some embodiments, the diol contains at least one ether linkage. In some embodiments the diol is further reacted with at a second diacid, or a diester of said second diacid, wherein said second diacid is different from said first diacid. Prepolymers produced from such processes and articles formed therefrom are also described.Type: ApplicationFiled: August 8, 2011Publication date: February 2, 2012Inventors: Valerie Ashby, David Olson
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Publication number: 20120027718Abstract: The subject invention provides a method of treating a subject afflicted with a form of multiple sclerosis comprising periodically administering to the subject an amount of glatiramer acetate and an amount of rasagiline or the pharmaceutically acceptable salt thereof, wherein the amounts when taken together are effective to alleviate a symptom of the form of multiple sclerosis in the subject so as to thereby treat the subject. The subject invention also provides a package comprising glatiramer acetate, rasagiline or the pharmaceutically acceptable salt thereof and instructions for use of the together to alleviate a symptom of a form of multiple sclerosis in a subject. The subject invention further provides a pharmaceutical combination comprising separate dosage forms of an amount of glatiramer acetate and an amount of rasagiline or the pharmaceutically acceptable salt thereof, which combination is useful to alleviate a symptom of a form of multiple sclerosis in a subject.Type: ApplicationFiled: August 4, 2011Publication date: February 2, 2012Inventors: Rivka Kreitman, Liat Hayardeny, Ruth Levy, Eran Blaugrund
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Publication number: 20120027821Abstract: Disclosed are cyanoacrylate polymer particles which comprise an amino acid(s) and have an average particle diameter of less than 1000 nm. The amino acid-containing particles according to the present invention can kill cancer cells by inducing apoptosis-like cell death. The particles have an especially high affinity for cell lines derived from lymphomas such as T-cell lymphoma and B-cell lymphoma. The particles can also exhibit an antiproliferative effect against some kinds of pancreatic cancer-derived cell lines. Therefore, the particles according to the present invention are useful for prevention and/or treatment of cancers.Type: ApplicationFiled: March 3, 2010Publication date: February 2, 2012Applicant: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITYInventors: Shoichi Shirotake, Atsushi Yoshida, Shumpei Yokota, Itaru Endo
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Patent number: 8105391Abstract: Provided herein are a method, which comprises implanting in a patient an implantable device comprising a coating that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.Type: GrantFiled: April 1, 2010Date of Patent: January 31, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Lothar W. Kleiner, Connie S. Kwok
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Publication number: 20120021015Abstract: Cross-linked fibers include first and second precursors, each possessing a core and at least one functional group known to have click reactivity when exposed to UV radiation. Mixtures of the first and second precursors are extruded to produce a filament and irradiated with UV light during the extrusion process.Type: ApplicationFiled: February 22, 2010Publication date: January 26, 2012Applicants: TYCO HEALTHCARE GROUP LP, SOFRADIM PRODUCTIONInventors: Ahmad Robert Hadba, Sébastien Ladet
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Publication number: 20120014909Abstract: A tissue adhesives and sealant formed by reacting a polyglycerol aldehyde with a water-dispersible, multi-arm amine is described. The tissue adhesive and sealant may be useful for medical and veterinary applications, including, but not limited to, wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and to prevent post-surgical adhesions.Type: ApplicationFiled: March 26, 2010Publication date: January 19, 2012Applicant: Actamax Surgical Materials, LLCInventor: Henry Keith Chenault
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Patent number: 8093352Abstract: Disclosed are polyquaternary ammonium polymers containing polyalkylene oxide groups according to formula (I) wherein [A]x, [B]y and [C]z are poly(alkylene oxides) each independently selected from the group consisting of poly(ethylene oxide), poly(propylene oxide), and poly(butylene oxide); Z is selected from the group consisting of —CH2CH?CHCH2—, —CH2CH2CH2CH2—, —CH2—C?C—CH2—, —CH2CH2—O—CH2CH2—, —CH2—N(CH2CH2)2N—CH2—, —CH2CH(OH)CH(OH)CH2— and —CH2—C6H4—CH2—; R is —(CR1R2)mCR3R4— wherein m is an integer from 0 to 3 and R1, R2, R3 and R4 are independently selected from the group consisting of H, CH3 and CH2CH3; n is an integer from 1 to 30; x is either 0 or an integer from 2 to 20; y is an integer from 2 to 20; z is either 0 or an integer from 2 to 20; R? is a branched or unbranched alkyl group having from 1 to 3 carbon atoms and is optionally substituted by one or two hydroxyl groups; Q1 and Q2 are independently selected from the group consisting of —CH2CH?CHCH2—X, —CH2C?C—CH2—X, —N(R?)2, —N(R?)3, —N(R?)(R?),Type: GrantFiled: August 5, 2009Date of Patent: January 10, 2012Assignee: Alcon Research, Ltd.Inventors: Ryan DeSousa, Nissanke L. Dassanayake, Howard Allen Ketelson
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Publication number: 20120003177Abstract: Curcumin, a polyphenol extracted from the rhizome turmeric, has been polymerized to produce a polymer material having a backbone of one or more repeating structural units, at least one of which comprises a curcumin monomer residue. These curcumin-containing polymers have a wide range of pharmacological activities, including, among others antitumor, antioxidant, antiinflammatory, antithrombotic and antibacterial activities. Certain species of these polymers have exhibited remarkable antitumor activity. Water-soluble curcumin derivatives and their use as prodrugs and prodrug carriers are also disclosed.Type: ApplicationFiled: September 17, 2009Publication date: January 5, 2012Inventors: Youqing Shen, Huadong Tang, Edward Van Kirk, William Murdoch, Maciej Radosz
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Publication number: 20120003271Abstract: A biocompatible polymer mixture for use as a matrix for cellular attachment includes a mixture of at least two polymers selected from the group consisting of: chitosan (CS), polyethylenimine (PEI), poly(L-lactic acid) (PLLA), poly(D-lactic acid) (PDLA), poly(2-hydroxy ethyl methacrylate) (PHEMA), poly(?-caprolactone) (PCL), poly(vinyl acetate) (PVAc), poly(ethylene oxide) (PEO), poly[(R)-3-hydroxybutyric acid)] (PHB), cellulose acetate (CA), poly(lactide-co-glycolide) (PLGA) and poly(N-isopropylacrylamide) (PNIPAM). Implants making use of the polymer mixtures can support cell attachment, growth and differentiation, and tissue regeneration in vivo.Type: ApplicationFiled: September 1, 2009Publication date: January 5, 2012Applicant: The University Court of th University of EdinburghInventors: Mark Bradley, Ferdous Khan, Richard O.C. Oreffo, Rahul Shrikant Tare
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Patent number: 8088400Abstract: An alcohol-soluble, water-insoluble, disinfectant composition and a method of using the same for disinfecting and for providing a prolonged antimicrobial property to a variety of surfaces, including skin. The composition comprises an antimicrobial polymer that is capable of imparting an antimicrobial property to a surface without the use of a metal or metal-containing compound. The composition is applied to a surface and allowed to evaporate leaving a coating of antimicrobial polymer.Type: GrantFiled: August 22, 2006Date of Patent: January 3, 2012Assignee: Quick-Med Technologies, Inc.Inventors: William Toreki, Gerald Olderman
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Publication number: 20110318394Abstract: The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins.Type: ApplicationFiled: February 5, 2010Publication date: December 29, 2011Applicant: KNC NER ACQUISITION SUB, INC.Inventors: Bruce P. Lee, Sunil Silvary, John L. Murphy
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Patent number: 8071082Abstract: Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.Type: GrantFiled: July 20, 2007Date of Patent: December 6, 2011Assignee: Massachusetts Institute of TechnologyInventors: Gregory T. Zugates, Andreas Zumbuehl, Robert S. Langer, Daniel G. Anderson
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Patent number: 8067505Abstract: Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(C?0)OR?, wherein R? is a tertiary group and R comprises a functional group X, is reacted with a water soluble, non-peptidic polymer POLY-Y, where Y is a functional group which reacts with X to form a covalent bond, to form a tertiary ester of the polymer, which is then treated with a strong base in aqueous solution, to form a carboxylate salt of the polymer. Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer.Type: GrantFiled: February 9, 2011Date of Patent: November 29, 2011Assignee: Nektar TherapeuticsInventors: J. Milton Harris, Antoni Kozlowski, Lihong Guo
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Publication number: 20110286958Abstract: Polymeric platinum amidomalonate complexes, where the platinum is in +2 or +4 oxidation state, and where the complexes optionally contain tumor seeking groups, are useful in the treatment of cancer.Type: ApplicationFiled: May 16, 2011Publication date: November 24, 2011Inventors: Paul Sood, N. Rao Ummaneni, Bruce Thurmond, Ryszard Zarzycki
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Publication number: 20110286959Abstract: Random three- and four-amino acid copolymers having lengths of 14-, 35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99- or proteolipid protein (PLP) 40-60-specific HLA-DR-2-restricted T cell clones. These copolymers efficiently suppressed the mouse disease EAE, which was induced in a susceptible SJL/J (H-2s) strain of mice with either whole spinal cord homogenate (WSCH) or with the encephalitogenic epitope PLP 139-151 (SEQ ID NO:4). YFAK 50-mer having a molar ratio of about Y 0.8:F 0.2 inhibited binding of biotinylated MBP 85-99 epitope to HLA-DR-2 molecules more efficiently than either unlabeled MBP 85-99 or Copaxone®. YFAK and FAK copolymers efficiently suppressed EAE induced in SJL/J (H-2S) mice with the encephalitogenic epitope PLP 139-151.Type: ApplicationFiled: July 12, 2011Publication date: November 24, 2011Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Jack L. Strominger, Masha Fridkis-Hareli
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Patent number: 8062656Abstract: The invention provides NO-releasing polymers and low molecular weight NO-releasing compounds which may be used to for the treatment of medical conditions associated with NO-deficiency. The NO-releasing polymers or the low molecular weight NO-releasing compounds may also be incorporated into medical devices. The invention further provides methods of controlled release of NO for the treatment of diseases and disorders associated with NO-deficiency, wherein the treatment includes systemic or local administration of the NO-releasing polymers or the low molecular weight NO-releasing compounds.Type: GrantFiled: April 18, 2008Date of Patent: November 22, 2011Assignee: Central Michigan UniversityInventors: Justin D. Oh-Lee, Dillip K. Mohanty
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Publication number: 20110274645Abstract: Methods of performing medical procedures, and methods of making bone-growth-promoting compositions useful in performing medical procedures are provided. Apparatus useful both in methods of performing medical procedures, and in methods of making bone-growth-promoting compositions useful in performing medical procedures, are provided. The bone-growth-promoting compositions made according to the disclosed methods are biocompatible, and are adapted to stimulate bone growth when positioned in contact with, or in the vicinity of, a bone of a mammal.Type: ApplicationFiled: May 24, 2011Publication date: November 10, 2011Inventors: Aisa Sendijarevic, Richard Deslauriers
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Publication number: 20110274733Abstract: Embodiments of the present invention provides medical devices comprising poly(hydroxyalkanoates) and agents.Type: ApplicationFiled: July 15, 2011Publication date: November 10, 2011Inventors: Syed F.A. Hossainy, Stephen D. Pacetti
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Publication number: 20110268690Abstract: Compositions comprising poly(hydroxyalkanoates) and agents for use with medical articles are described.Type: ApplicationFiled: July 15, 2011Publication date: November 3, 2011Inventors: Syed F.A. Hossainy, Stephen D. Pacetti
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Patent number: 8048407Abstract: A method and composition for treating arteriovenous malformations (AVMs), or abnormal vasculature in the body are provided. The method comprises introducing into the region of an AVM a composition comprising a nucleophilic component, such as a thiol, and a component containing a conjugated unsaturated bond, such as an acrylate through a catheter, whereby the composition crosslinks within the body to block or occlude the AVM.Type: GrantFiled: April 26, 2004Date of Patent: November 1, 2011Inventors: Brent Vernon, Merrill Birdno, Mark C. Preul
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Patent number: 8034844Abstract: Antiviral compositions having a rapid antiviral effectiveness, and a persistent antiviral effectiveness, are disclosed. The antimicrobial compositions contain (a) a powdered solid substrate and (b) an organic acid.Type: GrantFiled: May 29, 2007Date of Patent: October 11, 2011Assignee: The Dial CorporationInventors: Priscilla S. Fox, Daniel E. Pedersen, John J. Rolando, Richard K. Staub
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Publication number: 20110243885Abstract: This invention relates to methods of using genotyping to select patients for treatment with compounds capable of elevating ketone body concentrations in amounts effective to treat reduced neuronal metabolism associated with reduced neuronal metabolism, for example Alzheimer's disease.Type: ApplicationFiled: July 31, 2008Publication date: October 6, 2011Applicant: ACCERA, INC.Inventor: Samuel T. Henderson
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Publication number: 20110244006Abstract: This application provides a microsphere suitable for tissue engineering that comprises connective tissue growth factor (CTGF). Also provided is a matrix, material or scaffold suitable for tissue engineering that comprises connective tissue growth factor (CTGF) and basic fibroblast growth factor (bFGF). Additionally, methods of treating skin of a human are provided. The methods comprise administering to the skin microspheres comprising a growth factor that increases fibroblast proliferation or collagen, elastin, or glycosaminoglycan synthesis. Further provided are the use of the above microspheres for the treatment of the skin of a human. Additionally, this application proves the use of the above microsphere for the manufacture of a medicament for the treatment of the skin of a human.Type: ApplicationFiled: November 26, 2008Publication date: October 6, 2011Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Eduardo K. Moioli
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Publication number: 20110244001Abstract: A composite material containing polymeric nanofibers, themselves containing NO-donor molecules, imbibed with an elastomer matrix is permeable to both water and gas so that dissociation reactions in the presence of water releases NO gas in a sustained manner. The NO-donor nanofibers may be formed by synthesizing acceptable NO-donor molecules, blending such molecules in solution with PVP, PCL or PVAc, electrospinning the blend at relatively high voltage for form fiber mats, applying PDMS rubber to the fiber mat and crosslinking it. The resulting NO-releasing electrospun fiber composite may be used in medical devices such as catheters, stents, or vascular grafts, with the purpose of releasing nitric oxide within a controlled rate and for a sustained period of time, as well as other known medical applications for NO.Type: ApplicationFiled: April 6, 2011Publication date: October 6, 2011Applicant: Syracuse UniversityInventors: Patrick Mather, Ifeanyi Onyejewke, Kazuki Ishida
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Publication number: 20110243883Abstract: The present invention provides branched polymers which can be used as lubricants or shock absorbers in vivo. For example, the inventive polymers can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and sport-injured knee joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery.Type: ApplicationFiled: October 31, 2008Publication date: October 6, 2011Applicant: TRUSTEES OF BOSTON UNIVERSITYInventors: Mark W. Grinstaff, Michel Wathier, Neel Joshi, Stephanie Stoddart
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Publication number: 20110243884Abstract: The invention relates to a biodegradable polymer comprising a plurality of releasable bioactive moieties, the releasable bioactive moieties being pendant from and covalently bonded to the biodegradable polymer backbone, wherein the biodegradable polymer backbone is formed from monomeric units that are each coupled via a biodegradable moiety, and wherein the bioactive moieties are capable of being released at a rate equal to or faster than the rate of biodegradation of the polymer backbone.Type: ApplicationFiled: April 8, 2011Publication date: October 6, 2011Inventors: Michael Shane O'Shea, Florian Hans Maximilian Graichen, Russell John Tait, Heng Chy Taing, Justine Leigh Jeffery
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Publication number: 20110229555Abstract: Liposomal formulations and polymer conjugates of curcumin, curcumin analogues and derivatives thereof for parenteral administration are disclosed herein. The formulations are effective in the treatment of progressive supranuclear palsy, Alzheimer's disease (AD), Parkinson's disease (PD), Tauopathies or stress disorders including Post Traumatic Stress Disorder (PTSD). Curcumin crosses the blood brain barrier, localizes in the hippocampus and striata, prevents stress-induced neuronal cell damage, and stimulates neurogenesis and remediation of damaged neural circuits.Type: ApplicationFiled: March 21, 2011Publication date: September 22, 2011Applicant: SignPath Pharma Inc.Inventors: Lawrence Helson, Simon Chiu
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Patent number: 8021652Abstract: The present invention relates to a biodegradable branched polylactic acid derivative of formula 1, and preparation method and use thereof: <formula 1> 1-(R—X)n wherein each of X, R, I and n is defined as in the detailed description.Type: GrantFiled: December 3, 2004Date of Patent: September 20, 2011Assignee: Samyang CorporationInventors: Min-Hyo Seo, Bong-Oh Kim, In-Ja Choi, Myung-Seob Shim
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Patent number: 8017107Abstract: This invention provides water-swellable articles and hydrogels that contain a hydrophilic polymer and perfluorocyclobutane crosslinking segments. The perfluorocyclobutane crosslinking segments are covalently attached to the polymeric chains of the hydrophilic polymer so that the crosslinking segments chemically link the polymeric chains to each other. The present invention also provides a method of making a crosslinked hydrogel by first attaching one or more substituted aromatic trifluorovinyl or aromatic trifluorovinyl ether moieties to a hydrophilic polymer to form a modified polymer and then heating the modified polymer at an elevated temperature to form perfluorocyclobutane segments from the trifluorovinyl or trifluorovinyl ether moieties.Type: GrantFiled: December 21, 2006Date of Patent: September 13, 2011Assignee: Zimmer, Inc.Inventors: Brian Thomas, Kai Zhang
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Patent number: 8017714Abstract: An aromatic polyanhydride comprising a repeating unit having the structure is disclosed, wherein Ar and R are selected so that the aromatic polyanhydride hydrolyzes to form a therapeutic salicylate, another non-steroidal anti-inflammatory, an antifibrotic aminobenzoate, or a vasoconstricting phenylethanolamine. Implantable medical devices, such as scaffolding implants for tissue reconstruction, drug delivery systems prepared from the aromatic polyanhydrides, as well as therapeutic dosage forms and treatment methods are also disclosed.Type: GrantFiled: April 22, 2009Date of Patent: September 13, 2011Assignee: Rutgers, The State University of New JerseyInventor: Kathryn E. Uhrich
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Patent number: 8017151Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.Type: GrantFiled: September 7, 2004Date of Patent: September 13, 2011Assignee: Board of Regents of the University of Nebraska by and Behalf of the University of Nebraska Medical CenterInventors: Elena V. Batrakova, Serguei V. Vinogradov, Alexander V. Kabanov
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Publication number: 20110212049Abstract: The present disclosure provides injectable synthetic and biodegradable polymeric biomaterials that effectively prevent seroma, a common postoperative complication following ablative and reconstructive surgeries. Provided biomaterials include physically crosslinked hydrogels that are thixotropic, display rapid chain relaxation, are easily extruded through narrow gauge needles, biodegrade into inert products, are well tolerated by soft tissues, and effectively prevent seroma in a radical breast mastectomy animal model.Type: ApplicationFiled: November 3, 2009Publication date: September 1, 2011Applicant: CORNELL UNIVERSITYInventors: David Putnam, Peter Zaweneh, Jason Spector
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Publication number: 20110212050Abstract: Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.Type: ApplicationFiled: May 5, 2011Publication date: September 1, 2011Applicant: REVA Medical, Inc.Inventors: Donald K. Brandom, Joan Zeltinger, Eric V. Schmid, Joseph J. Mallon
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Patent number: 8007775Abstract: Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a poly(hydroxyalkanoate).Type: GrantFiled: December 30, 2004Date of Patent: August 30, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F.A. Hossainy, Stephen D. Pacetti
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Publication number: 20110195042Abstract: The present disclosure describes methods for enhancing an overall cooling sensation of an oral mucosa comprising administering a liquid composition comprising a thickening agent and/or a mucoadhesive polymer, a non-menthol coolant; and contacting the oral mucosa with the liquid composition. The disclosure also describes the liquid compositions.Type: ApplicationFiled: February 7, 2011Publication date: August 11, 2011Inventors: Thomas Edward Huetter, Tracy L. Grosick
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Patent number: 7976834Abstract: The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.Type: GrantFiled: November 14, 2007Date of Patent: July 12, 2011Assignee: Nektar TherapeuticsInventors: Xuan S. Zhao, Zhongxu Ren, Kazunori Emoto
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Publication number: 20110150977Abstract: Biodegradable cationic block copolymers are disclosed, comprising a hydrophilic block comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a hydrophobic block comprising second repeat units derived from a second cyclic carbonyl monomer by ring-opening polymerization; an optional endcap group; and a chain fragment derived from an initiator for the ring opening polymerization. The cationic block copolymers form aqueous micelle mixtures suitable for antimicrobial applications.Type: ApplicationFiled: December 23, 2009Publication date: June 23, 2011Inventors: James HEDRICK, Kazuki FUKUSHIMA, Yi Yan YANG
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Publication number: 20110150943Abstract: The invention relates to adhesives for medical applications and methods of their preparation and use.Type: ApplicationFiled: March 1, 2011Publication date: June 23, 2011Inventors: Andreas Werner Speitling, Philip Procter, Joachim Schomburg, Christian Schultz, Wolf-Dieter Jülich, Ulrike Lindequist, Frieder Schauer, Annett Mikolasch, Katrin Manda
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Patent number: 7964217Abstract: This invention relates to hydrolytically degradable gels of crosslinked poly(ethylene) glycol (PEG) structures. Addition of water causes these crosslinked structures to swell and become hydrogels. The hydrogels can be prepared by reacting two different PEG derivatives containing functional moieties at the chain ends that react with each other to form new covalent linkages between polymer chains. The PEG derivatives are chosen to provide covalent linkages within the crosslinked structure that are hydrolytically degradable. Hydrolytic degradation can provide for dissolution of the gel components and for controlled release of trapped molecules, including drugs. Reagents other than PEG can be avoided. The hydrolysis rates can be controlled by varying atoms adjacent to the hydrolytically degradable functional groups to provide substantially precise control for drug delivery in vivo.Type: GrantFiled: October 14, 2003Date of Patent: June 21, 2011Assignee: Nektar TherapeuticsInventor: J. Milton Harris
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Publication number: 20110142790Abstract: Polyol-bioceramic composites are prepared by the reaction of a polyol and polycarboxylic acid in the presence of a bioceramic. Implantable medical devices fabricated at least in part with the crosslinked polyol-bioceramic composite materials are useful in a wide variety of applications.Type: ApplicationFiled: November 23, 2010Publication date: June 16, 2011Applicant: Monash UniversityInventor: Qizhi Chen
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Publication number: 20110126767Abstract: The invention relates to a method for hatching of hatchery eggs comprising: (a) treating the egg shell surface with a coating composition comprising a coating agent, to form a coating on the surface of the egg's shell; and (b) incubating the egg under conditions to cause hatching to occur; wherein the yield of hatching of said hatchery eggs is improved as compared to control eggs not treated as defined in (a). The invention additionally relates to a composition for treating of hatchery eggs prior to incubation, wherein said composition comprising a coating agent, and wherein said composition improves the hatching yield of said hatchery eggs.Type: ApplicationFiled: January 10, 2008Publication date: June 2, 2011Applicant: NATRATEC INTERNATIONAL LTD.Inventors: Jacob Lahav, Emil Polyansky, Shaul Naschitz
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Publication number: 20110129436Abstract: The present invention is directed to a method of preventing adhesions between two tissue surfaces. The method includes providing a film comprising a condensation polymer of glycerol and a diacid, wherein the film does not contain anti-inflammatory drugs and positioning the film between a first tissue surface and a second tissue surface under conditions effective to prevent adhesion between said first tissue surface and said second tissue surface.Type: ApplicationFiled: February 17, 2009Publication date: June 2, 2011Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Howard I. Pryor, II, Cathryn A. Sundback, Joseph P. Vacanti
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Publication number: 20110129437Abstract: A platelet adhesion-resistant material is provided, which includes polytriuret-urethane consisting essentially of repeating structural units of formulae (I) to (III) in a random order, in which when the total number of the three repeating structural units in the polytriuret-urethane is 100, the number of the repeating structural units (I) is about 5 to about 50: in which each R independently represents a C2-C16 alkylene group, a C6-C30 aromatic group, a C6-C30 alicyclic group; n is an integer of 2 to 16; and R1 represents —(OCmH2m)p, in which m is an integer of 2 to 5, and p is an integer of 3 to 150.Type: ApplicationFiled: November 30, 2010Publication date: June 2, 2011Inventors: Ying-nan TSAI, Ken-Yuan Chang, Fa Chen Chi, Po-Yang Chen, Cheng-Tar Wu
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Publication number: 20110123479Abstract: The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.Type: ApplicationFiled: July 4, 2009Publication date: May 26, 2011Applicant: Bayer MaterialScience AGInventors: Heike Heckroth, Burkhard Köhler, Sebastian Dörr
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Patent number: 7947263Abstract: Biocompatible synthetic macromer compositions are provided including a first polymer having multiple functional groups and a second functionalized polyurethane prepolymer, which can be employed as an adhesive or sealant for medical/surgical uses.Type: GrantFiled: December 6, 2006Date of Patent: May 24, 2011Assignee: Tyco Healthcare Group LPInventors: Ahmad R. Hadba, Nadya Belcheva, John Kennedy, Mark Roby
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Publication number: 20110117145Abstract: Provided is a cosmetic including silicone microparticles, in which the silicone microparticles include 100 parts by mass of silicone elastomer spherical microparticles having a volume average particle diameter within a range from 0.1 to 100 ?m, and 0.5 to 25 parts by mass of a polyorganosilsesquioxane that coats a surface of the silicone elastomer spherical microparticles, and the silicone elastomer is capable of absorbing not less than 30 parts by mass of at least one oily substance selected from the group consisting of sebum, hydrocarbon oils and ester oils per 100 parts by mass of the silicone elastomer. Even if containing an unctuous agent, the cosmetic exhibits favorable feelings upon use, with no spreading difficulties, stickiness, greasiness, oily film feeling, or the like, and is also capable of suppressing problems caused by sebum, namely, changes in the makeup cosmetic properties of the cosmetic, changes in the color of the cosmetic, increased shine, and the like.Type: ApplicationFiled: January 26, 2010Publication date: May 19, 2011Applicant: Shin-Etsu Chemical Co., Ltd.Inventors: Yoshinori Inokuchi, Ryuichi Inaba, Ryuji Horiguchi
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Publication number: 20110104080Abstract: An oral care composition for the treatment of dry mouth comprising a polyethylene oxide with a molecular weight from about 200,000 to about 7,000,000, an anti-bacterial agent, and a sensate.Type: ApplicationFiled: October 28, 2010Publication date: May 5, 2011Inventors: David Salloum Salloum, Douglas Craig Scott, Donald James White, JR., John Christian Haught, Begonia Y Ho, Malgorzata Klukowska
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Patent number: RE42377Abstract: A composition including 2-hexyl cyanoacrylate and gold is useful in treating arteriovenous malformations (AVMs) and other body lumens to be blocked.Type: GrantFiled: July 12, 2007Date of Patent: May 17, 2011Assignees: Stryker Corporation, Stryker NV Operations LimitedInventors: Robert E. Krall, Charles W. Kerber, Kimberly Knox