Liposome Patents (Class 424/9.321)
  • Method for producing liposomes with increased percent of compound encapsulated
    Patent number: 6193998
    Abstract: The efficiency of encapsulating a drug into a liposomal formulation is increased by use of a lipid having a carbon chain containing from about 13 to about 28 carbons during preparation of the liposomes. Preferably the liposomes are multivesicular liposomes.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: February 27, 2001
    Assignee: SkyePharma Inc.
    Inventors: Qiang Ye, Mantripragada Bhima Sankaram
  • GPIb-lipid complex and uses thereof
    Patent number: 6177059
    Abstract: A complex comprising a lipid and a conjugate of GPIb and lipid having a functional group, and use thereof. The GPIb-lipid complex of the present invention is extremely useful as a platelet substitute, a pharmaceutical agent for the prophylaxis and treatment of angiopathy, vascular damages and thrombosis, a diagnostic for vWF deficiency and the like, a biological or medical reagent, a reagent for screening platelet aggregation suppressant or antithrombosis, and the like. The GPIb-lipid complex of the present invention is also useful as a diagnostic for finding the location of vascular lesion or thrombus formation, or a therapeutic agent therefor, since it accumulates at vascular lesions.
    Type: Grant
    Filed: December 3, 1998
    Date of Patent: January 23, 2001
    Assignee: Yoshitomi Pharmaceutical Industries, Ltd.
    Inventors: Hiroshi Matsuda, Kaeko Kamide, Yasuo Amatsuji, Takashi Imagawa, Yasuo Ikeda, Mitsuru Murata
  • Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
    Patent number: 6171614
    Abstract: The present invention provides glycophospholipid and peptide-phospholipid conjugates comprising a phospholipid moiety and a saccharide or peptide moiety joined by an ether linkage comprising a secondary or tertiary amine. The conjugate structure of the invention comprises a flexible spacer arm between the phospholipid and saccharide or peptide moieties which, being variable in length, serves to optimize saccharide or peptide bioactivity. This invention further provides a method for the synthesis of such conjugates comprising the step of reductive amination. The method is efficient, economical and provides a high yield of product. Glycophospholipid and peptide-phospholipid conjugates of the invention can be incorporated and, optionally, chemically polymerized in self-assembling systems such as membranes, bilayers, films, liposomes and the like, and find utility diagnostically and therapeutically in medical and immuno-biological applications.
    Type: Grant
    Filed: February 28, 2000
    Date of Patent: January 9, 2001
    Assignee: Emory University
    Inventors: Elliot L. Chaikof, Lijun Sun
  • Lipopolyamines as transfection agents and pharmaceutical uses thereof
    Patent number: 6171612
    Abstract: Lipopolyamines useful for the transfection of nucleic acid and methods of preparation thereof are disclosed. The lipopolyamines are of general formula I, in which R4 comprises at least one C10-C22 aliphatic radical.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: January 9, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: G{acute over (e)}rardo Byk, Daniel Scherman, Bertrand Schwartz, Catherine Dubertret