Particle Containing A Transition, Actinide, Or Lanthanide Metal (e.g., Hollow Or Solid Particle, Granule, Etc.) Patents (Class 424/9.32)
  • Patent number: 10302651
    Abstract: The present invention relates to a method of capturing, enriching, purifying, detecting or measuring a cell in a sample at a sub-nanogram level comprising providing a nanocomposition, contacting the sample with the nanocomposition to form a mixture solution and allowing the binding of the cell with the nanocomposition, applying a magnetic field to the mixture, and evaluating the presence of or absence of the cell. The nanocomposition is capable of capturing or enriching an analyte at a sub-nanogram level, and comprise a nanostructure operably linked to an analyte-capturing member.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: May 28, 2019
    Inventors: Aihua Fu, Zheng Meng
  • Patent number: 10251592
    Abstract: Systems and methods for noninvasively determining the function capacity of the kidney are provided. In the methods, first contrast agent is injected into the vasculature of a subject. The contrast agent is to be bound with functioning glomeruli of the kidney of the subject. Then, the kidney is imaged with a magnetic resonance imaging (MRI) system to acquire MRI images of the kidney. In the images, signal magnitudes or phases of voxels of regions bound with the contrast agent are different from signal magnitudes or phases of voxels of regions not bound with the contrast agent. Afterwards, the function capacity of the kidney is determined using the MRI images. Lastly, a report of the function capacity of the kidney is generated.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: April 9, 2019
    Assignee: Nephrodiagnostics LLC
    Inventors: Kevin Michael Bennett, Scott Charles Beeman
  • Patent number: 10231996
    Abstract: The present invention relates to highly biocompatible or nontoxic PVP (poly(n-vinyl-2-pyrrolidone) coated silver prussian blue nanoparticles (SPB-NPS: Ag3[Fe(CN)6] where PVP acts as stabilizing or capping agent. The as-synthesized nanoparticles (SPB-NPs) have been thoroughly characterized by several analytical tools. The SPB-NPs are highly stable for more than two weeks towards different physiological buffers or solutions with different pH (pH=6, ?7.4 & ?8). These nanoparticles (SPB-NPs) exhibit biocompatibility towards various normal cells (HUVEC, CHO, & ECV304) but show significant inhibition of proliferation of different cancer cells in vitro and tumor growth in C57/BL6/J mice model (aggressive murine melanoma cancer model: B16F10). Additionally, the SPB-NPs show excellent antibacterial activity towards gram-negative (E. coli) and gram-positive (B. subtilis) bacteria.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: March 19, 2019
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Sudip Mukherjee, Chitta Ranjan Patra
  • Patent number: 10167424
    Abstract: Provided are a nanophosphor and a silica composite including the nanophosphor. The nanophosphor has a core/first shell/second shell structure or a core/first shell/second shell/third shell structure, wherein the core includes a Yb3+-doped fluoride-based nanoparticle, the first shell is an up-conversion shell including a Yb3+ and Tm3+-codoped fluoride-based crystalline composition, the second shell is a fluoride-based emission shell, and the third shell is an outermost crystalline shell.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: January 1, 2019
    Assignee: Korea Institute of Science and Technology
    Inventors: Ho Seong Jang, Joon Soo Han, So Hye Cho, Seung Yong Lee
  • Patent number: 10087442
    Abstract: Disclosed are methods and compositions containing functionalized nanoporous silicon particles, useful in a variety of diagnostic and/or therapeutic regimens for delivery of genetic constructs to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing into selected host cells one or more selected nucleic acid molecules. The present disclosure is also directed to a method of treating a tumor, comprising the step of administering to an individual one or more of the compositions and formulations thereof as described herein.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: October 2, 2018
    Assignee: The Methodist Hospital
    Inventors: Haifa Shen, Mauro Ferrari, Jianliang Shen, Mingzhen Zhang
  • Patent number: 10067137
    Abstract: The present invention relates to a nanocomposition capable of capturing or enriching an analyte at a sub-nanogram level and methods thereof. The nanocomposition can comprise a nanostructure operably linked to an analyte-capturing member.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: September 4, 2018
    Assignee: NVIGEN, INC.
    Inventors: Aihua Fu, Zheng Meng
  • Patent number: 10005677
    Abstract: There is provided a method of producing microparticles using an emulsion based synthesis route including: Providing a first fluid phase and a second fluid phase, wherein the first fluid phase is a continuous phase and the second fluid phase is a dispersed phase comprising a dispersed material, wherein the continuous phase is immiscible with the dispersed phase; Mixing the first continuous phase and the second dispersed phase in the presence of a surfactant in a shear device to form an emulsion of droplets of controllable size and having a narrow drop size distribution; Drying the emulsion to form microparticles of controllable size and having narrow size distribution, and wherein the microparticles may comprise spherical, crumpled, dimpled, porous or hollow microparticles morphology. Also provided is a system including shear device and drying arrangement. Also provided are micro particles of controllable size and morphology formed by the method.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: June 26, 2018
    Assignee: University College Dublin, National University of Ireland, Dublin
    Inventors: Gil Lee, Mark Platt, James O'Mahony
  • Patent number: 9849193
    Abstract: The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles. An important attribute of a drug delivery system is its ability to allow for spatial and temporal regulated drug release, thereby minimizing side effects and improving therapeutic efficacy of conventional pharmaceuticals. Iron oxide nanoparticles (NPs), specifically Fe304 nanoparticles, possess many appropriate qualities that make them a viable choice for drug delivery.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: December 26, 2017
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Ralph J. Knipp, Michael H. Nantz
  • Patent number: 9835628
    Abstract: A core-shell nanoparticle is provided that includes a core comprising a first isotope of an element; an isolation layer surrounding the core; and a shell layer surrounding the isolation layer, wherein the shell layer comprises a second isotope of the element, with the first isotope being different than the second isotope. Methods are also provided for forming such core-shell nanoparticles.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: December 5, 2017
    Assignee: University of South Carolina
    Inventors: Jamie Lead, Ruth Merrifield
  • Patent number: 9782342
    Abstract: A composite magnetic nanoparticle drug delivery system provides targeted controlled release chemotherapies for cancerous tumors and inflammatory diseases. The magnetic nanoparticle includes a biocompatible and biodegradable polymer, a magnetic nanoparticle, the biological targeting agent human serum albumin, and a therapeutic pharmaceutical composition. The composite nanoparticles are prepared by oil-in-oil emulsion/solvent evaporation and high shear mixing. An externally applied magnetic field draws the magnetic nanoparticles to affected areas. The biological targeting agent draws the nanoparticles into the affected tissues. Polymer degradation provides controlled time release delivery of the pharmaceutical agent.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: October 10, 2017
    Assignee: Wichita State University
    Inventors: Ramazan Asmatulu, Heath Misak, Shang-You Yang, Paul Wooley
  • Patent number: 9645208
    Abstract: A material for use in a magnetic resonance system includes a carrier material and a doping material. The carrier material and the doping material are admixed in a specific proportion. A volume of the material smaller than 1 mm2 contains a substantially homogeneous intermixing of the carrier material and the doping material.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: May 9, 2017
    Assignee: SIEMENS AKTIENGESELLSCHAFT
    Inventors: Stephan Biber, Yvonne Candidus, Hubertus Fischer, Robert Greiner, Thomas Kundner
  • Patent number: 9549998
    Abstract: A kit for providing a contrast enhancer in a mammal for contrasting during imaging of the mammal comprises functionalized gold nanoparticles configured to be directed to one or more of a target organ, tissue and lesion of the mammal.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: January 24, 2017
    Assignee: The Curators of the University of Missouri
    Inventors: Vijaya Kattumuri, Kattesh V. Katti, Evan Boote, Raghuraman Kannan, Stan Casteel, Robert Churchill
  • Patent number: 9474809
    Abstract: An activatable nanoprobe is provided having a core component and an active agent associated with the core component via a bond configured to be cleaved upon exposure to an endogenous compound.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: October 25, 2016
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Swadeshmukul Santra, James Turkson
  • Patent number: 9399075
    Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.
    Type: Grant
    Filed: April 29, 2013
    Date of Patent: July 26, 2016
    Assignee: General Electric Company
    Inventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, Jr., Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino, Bruce Allan Hay, Amit Mohan Kulkarni
  • Patent number: 9328143
    Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and prodrug conjugates of the invention can be used to vectorize molecules of pharmaceutical or diagnostic interest, such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes, and notably to promote their transport across the blood-brain barrier (BBB).
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: May 3, 2016
    Assignees: VECT-HORUS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LA MEDITERRANEE (AIX MARSEILLE II)
    Inventors: Michel Khrestchatisky, Marion David, Yves Molino, Patrick Vlieghe
  • Patent number: 9295651
    Abstract: The invention provides a drug-polymer nanoconjugate that includes a drug covalently bonded to a polymer. The nanoconjugate can include a block copolymer coating and/or an albumin coating. The drug of the drug-polymer nanoconjugate can be one or more of a variety of therapeutic agents linked to the polymer through ether or thioether linkages formed from hydroxyl or thiol groups of the drug. The albumin coating can substantially or completely retard or prevent aggregation of the nanoconjugates in solid form or in solution. The invention further provides compositions that include a plurality of drug-polymer nanoconjugates, as well as methods for using the drug-polymer nanoconjugates, such as in therapeutic or diagnostic applications.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: March 29, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jianjun Cheng, Rong Tong
  • Patent number: 9267951
    Abstract: This invention relates to a composition comprising a micelle for use in biological applications, the micelle comprising: a substantially water-insoluble conjugated polymer which exhibits luminescence or fluorescence from about 300 nm to about 1500 nm of the electromagnetic spectrum: a biocompatible surfactant and/or lipid: and a MRI active agent.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: February 23, 2016
    Assignee: King's College London
    Inventors: Mark Green, Philip Howes
  • Patent number: 9251937
    Abstract: A method of sterilizing a nanoparticle preparation at a high temperature is provided. A plurality of nanoparticles are purified to form the preparation, wherein the nanoparticles comprise at least a core and a shell and the shell comprises one or more ligand species attached to the core. The nanoparticle preparation is made by a purified nanoparticle composition, a carrier fluid and an excess of the one or more ligand species not attached to the core. The ligand species attached to the core and the excess ligand species added after purification are structurally identical. The nanoparticle preparation provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: February 2, 2016
    Assignee: General Electric Company
    Inventors: Brian Christopher Bales, Brian James Grimmond, Daniel Eugene Meyer, Bruce Allan Hay, Michael Todd Luttrell
  • Patent number: 9229077
    Abstract: A device for spatially encoding nuclear magnetic resonance signals is provided. The device includes a plurality of spatial-encoding elements configured to produce a spatial-encoding magnetic field in the presence of an external magnetic field, such as the main magnetic field of a magnetic resonance imaging (“MRI”) system. The spatial-encoding elements include paramagnetic and diamagnetic spatial-encoding elements. The device further includes a support configured to hold the plurality of spatial-encoding elements in a fixed arrangement. By adjusting the orientation of the device, the spatial-encoding elements are moved relative to each other and thereby produce a plurality of different spatial-encoding magnetic fields. These spatial-encoding magnetic fields are used to spatially encode nuclear magnetic resonance signals emanating from spins in a volume-of-interest adjacent the device. An image reconstruction method for reconstructing images from signals spatially-encoded with the device is also provided.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: January 5, 2016
    Assignee: SUNNYBROOK HEALTH SCIENCES CENTRE
    Inventors: Charles H Cunningham, Hirad Karimi
  • Patent number: 9205155
    Abstract: The present application discloses treating water insoluble nanoparticles, particularly nanoparticles of metals and metal compounds which find utility in diagnostic imaging such as MR and X-ray imaging, with an alpha-hydroxyphosphonic acid conjugate with a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are ethylene oxide based polymers and copolymers and zwitterions and the nanoparticles are composed of transition metal oxides such as superparamagnetic iron oxide and tantalum oxide. Disclosed are nanoparticles which are sufficiently hydrophilic to form stable aqueous colloidal suspensions. Also disclosed is diagnostic imaging such as MR and X-ray using the modified hydrophilic nanoparticles as contrast agents.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: December 8, 2015
    Assignee: General Electric Company
    Inventors: Brian Christopher Bales, Bruce Allan Hay, Binil Itty Ipe Kandapallil
  • Patent number: 9196405
    Abstract: A method of preparing a dispersion of stabilized iron oxide nanoparticles that comprise cores and coatings on the cores, which comprise zwitterionic functional groups chemically bound to the cores, using a single solution that comprises dissolved iron ions and a zwitterion silane and/or a hydrolyzed product of the zwitterion silane.
    Type: Grant
    Filed: April 3, 2013
    Date of Patent: November 24, 2015
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Joseph B. Schlenoff, Zaki G. Estephan
  • Patent number: 9149545
    Abstract: The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites. Included herein are methods for forming such agents, comprising forming an ensemble of core/shell nanoparticles, wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: October 6, 2015
    Assignee: General Electric Company
    Inventors: Peter John Bonitatibus, Jr., David Cheney deMoulpied, Andrew Soliz Torres, Amit Mohan Kulkarni, Robert Edgar Colborn, Paul William Buckley
  • Patent number: 9098680
    Abstract: In accordance with the teaching described herein, systems and methods are provided for providing secure access to a software application on a computing device. The software application may include a security framework having a set of predetermined security requirements. Prior to enabling access to the software application by a user, the computing device may, (i) verify installation of a device security configuration profile on the computing device, wherein the device security configuration profile certifies that the software application includes the set of predetermined security requirements, (ii) receive identifying information from the user via a user interface, (iii) verify the identifying information with an authentication server, and (iv) based on a successful verification of the identifying information, receive and store a security token. Access to the software application on the computing device may be provided for a specified period identified by the security token.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: August 4, 2015
    Assignee: AbbVie Inc.
    Inventor: Sembian Balasubramanian
  • Publication number: 20150132231
    Abstract: Method and compositions are provided that relate to superparamagnetic nanoparticles, including IONP with small diameter and high transverse relaxivity, that are stable in an aqueous environment. The nanoparticle surface coating is functionalized, while minimizing its thickness, to facilitate packaging within biological constructs.
    Type: Application
    Filed: November 5, 2014
    Publication date: May 14, 2015
    Inventors: Benjamin Yen-Bin Ko, James Robert Swartz
  • Publication number: 20150125398
    Abstract: The invention provides particles useful for sequential imaging or for diagnostics or therapeutics. Disclosed is a method to image diagnostic or therapeutic cells in a mammal, comprising: introducing to a mammal a composition comprising mammalian cells comprising mesoporous silica nanoparticles (MSNs) comprising a lanthanide, a fluorophore and an agent detectable by ultrasound; applying ultrasound and/or a magnetic field to the mammal and recording ultrasound and/or magnetic resonance images that include the MSNs; and detecting the presence, location or amount of the MSNs in the mammal.
    Type: Application
    Filed: March 13, 2013
    Publication date: May 7, 2015
    Inventors: Jose G Assouline, Brian G. Trewyn, Sean K Sweeney, Kapil Kandel
  • Patent number: 8999294
    Abstract: The present invention relates to diagnostic and therapeutic nanoparticles. More particularly, the present invention relates to creating a copper (Cu)-based nanoparticle and a method for making the same. The Cu-based nanoparticles can further be incorporated with additional therapeutic or diagnostic compounds and used for the diagnosis and treatment of tumors.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: April 7, 2015
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Wei Chen, Yuebin Li
  • Publication number: 20150064107
    Abstract: The invention relates to imaging agents, and in particular to multi-modal nanoparticle (NPIA) imaging agents offering magnetic, radionuclide and fluorescent imaging capabilities to exploit the complementary advantages of magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT) and optical imaging (OI). The invention extends to these new types of agents per se, and to uses of such agents in various biomedical applications, such as in therapy and in diagnosis.
    Type: Application
    Filed: August 28, 2014
    Publication date: March 5, 2015
    Applicant: King's College London
    Inventors: Xianjin Cui, Philip Blower, Mark A. Green
  • Publication number: 20150064110
    Abstract: The present invention relates to a method for preparing beads comprising imaging agent. The present invention further provides beads highly useful for medical imaging.
    Type: Application
    Filed: February 22, 2013
    Publication date: March 5, 2015
    Applicants: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite Paris Diderot - Paris 7, Univ Paris XIII Paris-Nord Villetaneuse
    Inventors: Sidi Mohammed Derkaoui, Catherine Le Visage, Thomas Bonnard, Didier LeTourneur, Jean-Michel Serfaty
  • Patent number: 8968705
    Abstract: The present disclosure is directed generally to gold/lanthanide nanoparticle conjugates, such as gold/gadolinium nanoparticle conjugates, nanoparticle conjugates including polymers, nanoparticle conjugates conjugated to targeting agents and therapeutic agents, and their use in targeting, treating, and/or imaging disease states in a patient.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: March 3, 2015
    Assignee: Colorado School of Mines
    Inventors: Stephen G. Boyes, Misty D. Rowe
  • Publication number: 20150056145
    Abstract: Provided are a SAMiRNA-magnetic nanoparticle complex capable of effectively delivering a double-stranded oligo RNA and magnetic nanoparticles into a cell and a composition capable of simultaneously performing diagnosis and therapy of diseases such as cancer, and the like, containing the same. More specifically, provided is the SAMiRNA-magnetic nanoparticle complex consisting of double-stranded oligo RNA-polymer structures in which a hydrophilic material and a second hydrophobic material are bound to the double-stranded oligo RNA by a simple covalent bond or a linker-mediated covalent bond, and the magnetic nanoparticles in which a first hydrophobic material is bound onto a surface of the magnetic material, as a core. The SAMiRNA-magnetic nanoparticle complex may have a homogeneous size by a hydrophobic interaction between the first hydrophobic material of the present invention and the second hydrophobic material of the double-stranded oligo RNA structure.
    Type: Application
    Filed: January 17, 2013
    Publication date: February 26, 2015
    Inventors: Jeiwook Chae, Hyunjin Chung, Boreum Lee, Han Oh Park
  • Publication number: 20150056144
    Abstract: A therapeutic or diagnostic delivery vehicle is provided. The delivery vehicle may include one or more particles, such as microparticles, nanoparticles and stimuli-responsive particles, conjugated to a tropic cell that targets at least one pathological entity or site. In addition, a pharmaceutical composition is provided. The pharmaceutical composition may include, among other things, a particle conjugated to a tropic cell such as those discussed above and at least one diagnostic or therapeutic agent, such as those described herein. In some aspects, the tropic cell may target at least one pathological entity or site. Further, methods for diagnosing, monitoring or treating a pathological condition in a subject are provided. Such methods may include administering a therapeutically effective amount of the pharmaceutical composition to a subject.
    Type: Application
    Filed: April 18, 2014
    Publication date: February 26, 2015
    Inventors: Karen ABOODY, Alexander ANNALA, Rachael MOONEY, Jacob BERLIN, Yiming WENG
  • Patent number: 8945512
    Abstract: Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a paramagnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111).
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: February 3, 2015
    Assignee: Bracco Imaging SpA
    Inventors: Silvio Aime, Enzo Terreno, Daniela Delli Castelli, Giovanni Battista Giovenzana
  • Publication number: 20150017102
    Abstract: Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast agents is described, and uses for such imaging markers and contrast agents in a variety of therapeutic applications and devices.
    Type: Application
    Filed: August 25, 2014
    Publication date: January 15, 2015
    Inventors: Steven J. FRANK, Karen Martirosyan
  • Patent number: 8932485
    Abstract: The present invention provides fluorescent nanoparticle composites themselves, the process of preparing such composites, to systems for rapid diagnosis (as “kits”) containing such composites, and to the use of such composites. In a preferential embodiment, the composites of the present invention have an affinity for biological molecules, such as DNA. The present invention also comprises the preparation of probes containing biological material, upon which are added fluorescent nanoparticle composites, making viable a rapid and economic biological diagnosis of, for example, diseases and genetic traits, notably in the medical and veterinarian fields.
    Type: Grant
    Filed: March 23, 2009
    Date of Patent: January 13, 2015
    Assignee: Universidade Federal de Pernambuco-UFPE
    Inventors: Celso Pinto De Melo, César Augusto Souza De Andrade, Clécio Gomes Dos Santos
  • Publication number: 20150010476
    Abstract: The present application concerns multimodal composite products for imaging, in particular for diagnostic imaging, and optionally for therapy, in particular composite products which are capable of being used as contrast agents, in particular in magnetic resonance imaging (MRI), and/or in imaging techniques such as, for example, in optical imaging, in the optical detection of oxidants, in positron emission tomography (PET), in tomodensitometry (TDM) and/or in ultrasound imaging, and optionally simultaneously for use in therapy. These products are based on a particle comprising or consisting of a portion provided with a contrast agent activity and/or a paramagnetic activity, and a portion provided with a luminescent activity and optionally an oxidant detection activity.
    Type: Application
    Filed: March 8, 2013
    Publication date: January 8, 2015
    Inventors: Markus Schoeffel, Antigoni Alexandrou, Cedric Bouzigues, Thierry Gacoin, Jean-Pierre Boilot
  • Publication number: 20140377175
    Abstract: Provided herein are compositions and methods of preparing nanoparticle aggregates.
    Type: Application
    Filed: June 24, 2014
    Publication date: December 25, 2014
    Inventors: Jacob Berlin, Desiree van Haute
  • Publication number: 20140369938
    Abstract: The present invention discloses biocompatible, stable curcumin or its derivatives coated ultra-small super paramagnetic iron oxide nanoparticles (USPION) for biomedical applications. Disclosed herein is also a simple one-pot process for the synthesis of biocompatible, stable curcumin or its derivatives coated ultra-small superparamagnetic iron oxide nanoparticles in absence of a linker or binder. The curcumin or its derivatives coated ultra-small super paramagnetic iron oxide nanoparticles of the present invention retains the medicinal, radical scavenging and fluorescence properties of curcumin.
    Type: Application
    Filed: January 17, 2013
    Publication date: December 18, 2014
    Applicant: Council of Scientific & Industrial Research
    Inventors: Alias Joy Pattayil, Kunnoth Naduvilidam Jayaprabha
  • Publication number: 20140369937
    Abstract: An activatable nanoprobe is provided having a core component and an active agent associated with the core component via a bond configured to be cleaved upon exposure to an endogenous compound.
    Type: Application
    Filed: June 24, 2014
    Publication date: December 18, 2014
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Swadeshmukul Santra, James Turkson
  • Patent number: 8906345
    Abstract: The invention provides multimeric particle comprising metal-containing particles covalently bonded to one another by linker groups wherein at least some of said linker groups are cleavable. The invention further provides a contrast agent comprising said multimeric particles, along with a method of improving contrast of an image using said contrast agent.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: December 9, 2014
    Assignee: Isis Innovation Limited
    Inventors: Daniel Anthony, Benjamin Guy Davis, Nicola Sibson
  • Publication number: 20140348755
    Abstract: Nanoparticles, such as liposomes etc., containing multiple reporter molecules, e.g. dyes, fluorophores, FRET pairs, semiconductor nanocrystals, fluorescent chelates, chelate complexes, coordination complexes, mass tags, Raman tags, lanthanides, enzymes, enzymatic substrates, etc., through a combination of multiple physical and/or chemical interactions are disclosed. The reporter molecules are associated with the nanoparticle in at least two different ways, i.e. through different mechanisms. The nanoparticle is targeted through a targeting agent such as an antibody, an antibody fragment, a nucleotide, a peptide, an aptamer, biotin, avidin, or a ligand. The nanoparticles are useful in bioassays or imaging where an analyte is to be detected by binding of the nanoparticle to the analyte and detection of a signal from the reporter molecules.
    Type: Application
    Filed: September 20, 2012
    Publication date: November 27, 2014
    Inventor: Kevin C. Weng
  • Patent number: 8894968
    Abstract: The invention relates to pharmaceutical agents containing a particulate inorganic matrix having a diameter of from 0.1 nm to 100 ?m, preferably 1 nm to 10 ?m, particularly preferably 1 nm to 1 ?m, such as, for example, topaz, (Al2F2)[SiO4], and chiolite, Na[Al3F4], preferably wavellite, Al3(PO4)2(OH,F)2, calcium carbonate, CaCO3, maghemite, ?-Fe2O3, particularly preferably zeolites, gen. formula Mn[(AlO2)x(SiO2)y] (M=metal, e.g.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: November 25, 2014
    Assignee: nanoPET Pharma GmbH
    Inventor: Kristian Schilling
  • Patent number: 8889103
    Abstract: A diagnostic agent composition is provided which comprises a nanoparticle composition and a pharmaceutically acceptable carrier or excipient. The nanoparticle composition comprises a nanoparticulate metal oxide and a phosphorylated polyol, wherein the phosphorylated polyol comprises at least two phosphate groups and one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. The disclosure provides detailed guidance on methods of making and using such diagnostic agent compositions. The diagnostic agent compositions provided by the present invention are useful as contrast agents for medical diagnostic imaging techniques such as magnetic resonance (MR) imaging and X-ray imaging. The diagnostic agent composition may be administered to a subject via a variety of techniques, among them injection, inhalation, and ingestion.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: November 18, 2014
    Assignee: General Electric Company
    Inventors: Bruce Allan Hay, Brian Christopher Bales, Michael Todd Luttrell, Binil Itty Ipe Kandapallil
  • Publication number: 20140335025
    Abstract: Disclosed herein are compositions comprising a targeted corrole nanoparticle; and an acceptable excipient. Also disclosed are compositions comprising a targeted corrole nanoparticle; and an acceptable carrier. Further, disclosed herein are methods of imaging a condition in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; administering an effective amount of the targeted corrole nanoparticle to the subject; and imaging the condition in the subject. In addition, disclosed herein are methods of treating cancer in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; and administering a therapeutically effective dosage of the targeted corrole nanoparticle to the subject.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventor: Lali K. MEDINA-KAUWE
  • Publication number: 20140328765
    Abstract: The present invention relates a T1-T2 dual-modal MRI (magnetic resonance imaging) contrast agent, comprising (a) a first layer consisting of T1 contrast material; (b) a second layer consisting of T2 contrast material; and (c) a separating layer which is present in a space between the first layer and the second layer, and inhibits a reciprocal interference between T1 contrast material and T2 contrast material, and a heat-generating composition and a drug delivery composition having the same. The T1-T2 dual-modal contrast agent of the present invention may generate both T1 and T2 signal and thus observe the signal complementarily, resulting in accurate diagnosis through reduction of misdiagnosis. Further, T1 and T2 MR imaging may be simultaneously obtained by simple operation within the same MR imaging device, enabling to remarkably reduce a diagnosis time and diagnosis cost.
    Type: Application
    Filed: July 21, 2014
    Publication date: November 6, 2014
    Inventors: Jin Woo CHEON, Jin-Sil CHOI
  • Patent number: 8877207
    Abstract: Disclosed is a composition immunologically targeted to Alzheimer's disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an amyloid-beta antigen associated with AD. The invention also includes a medication manufactured with the targeted nanoceria particles and methods of treatment by administering the targeted nanoceria particles to patients in need thereof.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: November 4, 2014
    Assignees: University of Central Florida Research Foundation, Inc., University of l'Aquila
    Inventors: Annamaria Cimini, Barbara D'Angelo, Soumen Das, Sudipta Seal
  • Patent number: 8877162
    Abstract: A microparticle for drug delivery comprises an active agent and an excipient, the excipient comprising a metal ion-lipid complex. The metal ion is chosen from the group consisting of lanthanide metals, actinide metals, group IIa and IIIb metals, transition metals or mixtures thereof. The lipid comprises a phospholipid. The complex results in a glass transition temperature increase of the microparticle.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: November 4, 2014
    Assignee: Novartis AG
    Inventors: Luis A. Dellamary, Jean Reiss, Ernest G. Schutt, Jeffry G. Weers, Thomas E. Tarara
  • Publication number: 20140314679
    Abstract: Provided are compositions for rapid detection of lymph nodes. The compositions include magnetic particles, such as iron oxide, and a solute present in an amount that results in a hypoosomotic solution. Methods for detecting lymph nodes also are provided.
    Type: Application
    Filed: March 10, 2014
    Publication date: October 23, 2014
    Applicant: ENDOMAGNETICS LTD.
    Inventors: Andrew P. Shawcross, John Gonzalez-Carvajal, Marc Brown, Rob Turner
  • Publication number: 20140308213
    Abstract: A nanophosphor in accordance with one exemplary embodiment of the present disclosure includes a fluoride-based nanoparticle co-doped with Ce3+ and one selected from a group consisting of Tb3+, Eu3+ and a combination thereof. The nanophosphor may be excited by a single wavelength of ultraviolet rays to emit various colors of green, yellow, orange, red and the like, and exhibit high photostability without photoblinking. The nanophosphor may be utilized as a bio imaging contrast agent, a transparent display device, an anti-counterfeit code and the like.
    Type: Application
    Filed: April 11, 2014
    Publication date: October 16, 2014
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Ho Seong JANG, Kyoungja WOO, Su Yeon KIM
  • Publication number: 20140294734
    Abstract: Example apparatus and methods provide improved spatial and temporal resolution over conventional magnetic resonance renography (MRR). Example apparatus and methods reconstruct under-sampled three-dimensional (3D) data associated with nuclear magnetic resonance (NMR) signals acquired from a kidney. The data is reconstructed using a 3D through-time non-Cartesian generalized auto-calibrating partially parallel acquisitions (GRAPPA) approach. Example apparatus and methods produce a quantized value for a contrast agent concentration in the kidney from a signal intensity in the data based, at least in part, on a two compartment model of the kidney. The two compartment model includes a plasma compartment and a tubular compartment. The quantized value describes a perfusion parameter for the kidney or a filtration parameter for the kidney.
    Type: Application
    Filed: November 20, 2013
    Publication date: October 2, 2014
    Inventors: Vikas Gulani, Katherine Wright, Nicole Seiberlich, Mark Griswold
  • Patent number: 8840868
    Abstract: Methods of non-invasive imaging of complement-mediated inflammation are provided. Compositions including CR-targeted ultrasmall superparamagnetic nanoparticles or aggregates thereof for use with those methods are also provided.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: September 23, 2014
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Joshua M. Thurman, Natalie Serkova, Conrad Stoldt, Brian Larsen, V. Michael Holers