Burn Treatment Patents (Class 424/DIG13)
  • Patent number: 6147053
    Abstract: The invention relates to active substance combinations which consist of at least one polypeptide with the biological action of fibroblast growth factors and of at least one cationic polyelectrolyte. These combinations permit improved dosage of the FGF activity.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: November 14, 2000
    Assignee: Merck Patent Gesellschaft MIT
    Inventor: Berthold Nies
  • Patent number: 6017551
    Abstract: A salve or skin care product for treating discomfort due to burned, inflamed or irritated skin includes a mixture of naturally occurring neutral organic glyceryl esters of fatty acids, such as lard, and small particles of the bark of an Alder tree. The small particles are obtained by pulverized, milling or the like.
    Type: Grant
    Filed: December 11, 1998
    Date of Patent: January 25, 2000
    Inventor: George E. Riley
  • Patent number: 5997876
    Abstract: This invention refers to the sphere of medicine, in particular to pharmaceutics and concerns the preparations for burn treatment. The technical result of the present invention is in widening the assortment of medicinal preparations for treatment of bums and wounds, in increasing treatment effect. The ointment contains the components in the following relation of mass parts:______________________________________ celandine Chelidonium majus 15-25 g plantain Plantago major 15-25 g matricary Matricaria chamomilla 15-25 g yarrow Achillea millefolium 15-25 g calendula Calendula officinalis 15-25 g St.
    Type: Grant
    Filed: November 10, 1998
    Date of Patent: December 7, 1999
    Inventors: Nino Shikhashvili, Zurab Darsavelidze
  • Patent number: 5976555
    Abstract: Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability. More particularly, said skin care compositions contain (a) an emulsifier system selected from the group consisting of: (i) a mixture of glyceryl stearate and polyethylene glycol 100 stearate; (ii) cetearyl alcohol and cetearyl glucoside; (iii) a mixture of a polyethylene glycol ethers of stearyl alcohol; and (iv) a mixture of sorbitan stearate and polysorbate 60; (b) a co-emulsifier selected from the group consisting of cetyl alcohol, stearyl alcohol and mixtures thereof; (c) an oil phase present in the amount of from about 5 to about 20 percent by weight of the total emulsion composition which contains (i) a light, dry absorbable oil and (ii) substantive, emollient oils or waxes, wherein the light, dry absorbable oil and the substantive oil or wax are present in a ratio of from about 1:3 for about 10:1.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: November 2, 1999
    Assignee: Johnson & Johnson Consumer Products, Inc.
    Inventors: Jue-Chen Liu, Jonas C. T. Wang, Mohammed Yusuf, Norihiro Yamamoto, Satoshi Kazama, Christopher R. Stahl, Jean P. Holland, Kamran Mather, Margaret A. Aleles, Sachio Hamada, Curtis A. Cole
  • Patent number: 5973010
    Abstract: A composition and method for treating epidermal wounds utilizes an aqueous solution of sodium sulphate, sodium carbonate, sodium bicarbonate, sodium chloride and ichthammol.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: October 26, 1999
    Inventor: Robert L. Crawford
  • Patent number: 5914124
    Abstract: Alginate fibres comprising at least one medicament incorporated into the structure thereof, the medicament being present at a level of at least 10% by weight, based on the weight of the alginate fibre with no incorporated medicament.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: June 22, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Peter M. J. Mahoney, David Pritchard, Anne Elizabeth Howells, Bryan Griffiths
  • Patent number: 5888984
    Abstract: The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates and natural or synthetic essential oils can work effectively as a topical pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion cascade.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: March 30, 1999
    Assignee: Dermal Research Laboratories, Inc.
    Inventor: Harold G. Brown
  • Patent number: 5885960
    Abstract: The invention relates to active substance combinations which consist of at least one polypeptide with the biological action of fibroblast growth factors and of at least one cationic polyelectrolyte. These combinations permit improved dosage of the FGF activity. The invention also relates to a method of treating wounds, burns, skin ulcers, diabetic gangrene, mucosal ulcers and lesions, skin donation and transplantation sites, or surgical wounds by administering a peptide having FGF activity with an amount of cationic polyelectrolyte which is effective to decrease non-specific binding of the peptide having FGF activity.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: March 23, 1999
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventor: Berthold Nies
  • Patent number: 5882639
    Abstract: A method for treating photodermatitis, thermal burn, decubitus ulcer, or herpes zoster by topically applying a composition comprising a water soluble vinyl polymer gel or lotion comprising 1H-imidazole-4-ethanamine, phosphate uniformly mixed therewith to the affected areas.
    Type: Grant
    Filed: February 9, 1998
    Date of Patent: March 16, 1999
    Assignee: Professional Pharmaceutical, Inc.
    Inventors: Bruce A. Jack, B. Thomas White
  • Patent number: 5851522
    Abstract: This invention relates to the use of a particular form of collagenase substantially free of other proteinases to increase the motility of karatinocytes.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 22, 1998
    Assignee: Trustees of Tufts College
    Inventor: Ira M. Herman
  • Patent number: 5830739
    Abstract: Method is described for obtaining a novel proteolytic mixture containing escharase from bromelain.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: November 3, 1998
    Assignee: the estate of Gerold K.V. Klein
    Inventors: John C. Houck, Gerold K. V. Klein
  • Patent number: 5820874
    Abstract: The present invention is concerned with alginate fibres, and in particular the use thereof as a wound dressing and a method of preparing the same. There is provided alginate fibres for use in the absorption of at least 10% by weight based on the weight of the alginate fibres of proteinaceous material from a wound environment into the structure of the fibres.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: October 13, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Peter M. J. Mahoney, Anne Elizabeth Howells
  • Patent number: 5804213
    Abstract: The invention provides a prepackaged dressing including dry particulate solids for forming a pourable, water-based natural or synthetic hydrocolloidal polyemeric gel to dress wounds. The gel contains a biologically active constituent. Liquid and dry, solid particulate components are separate and are mixed just before use. One dry constituent is the hydrocolloid which is contained in a compartment of a sealed container separate from moisture. After mixing with water, the dry hydrocolloid does not become fully hydrated immediately. The liquid component (water) provides a fluid consistency initially. At this stage, the admixture is sufficiently fluid in consistency to allow it to be poured or spread into a wound. Following application to the wound, the hydrated hydrocolloidal dispersion begins to solidify to form a solid, self-supporting flexible dressing structure consisting primarily of water, the hydrocolloid, as well as the biologically active constituent, e.g.
    Type: Grant
    Filed: July 15, 1992
    Date of Patent: September 8, 1998
    Assignee: LecTec Corporation
    Inventor: David Rolf
  • Patent number: 5795573
    Abstract: A homeopathic topical anti-inflammatory and pain relieving composition containing an effective amount of the combination of Arnica Montana, Rhus toxicodendron and Aesculus hippocastanum together with belladonna in the form of a lotion, cream or gel.
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: August 18, 1998
    Inventor: Lou Paradise
  • Patent number: 5783201
    Abstract: Vitamin B12 is used to stimulate heme oxygenase production. In turn, levels of the molecules 12(R)-HETE and 12(R)-DIHETE, which are arachidonic acid derivatives, are reduced. Various topical formulations containing vitamin B12, but no other vitamins, are described.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: July 21, 1998
    Assignee: Hemogen, Inc.
    Inventors: Richard D. Levere, Nadar G. Abraham, Michal L. Schwartzman, Michael W. Dunn
  • Patent number: 5766614
    Abstract: A new Burn Treatment Composition which provides healing to the skin of people who have received burns or are afflicted with other skin complications that require healing. The inventive device includes effective amounts of Chinese rhubarb; calcium hydroxide; sanguisorba officinalis rhizome; common camphor; coptis chinensis rhizome; phellodendron amurense bark and oldenlandia diffusa roxd.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: June 16, 1998
    Inventor: Liu Yong
  • Patent number: 5750149
    Abstract: Pharmaceutical and/or dermocosmetic compositions containing equine colostrum, optionally in admixture with milk.
    Type: Grant
    Filed: August 14, 1995
    Date of Patent: May 12, 1998
    Assignee: Horse Vitality Ltd
    Inventor: Rosa Maria Gobbi
  • Patent number: 5728762
    Abstract: An improved polyurethane is prepared by reacting a diol component and an organic diisocyanate with critical selection of the amount of water in the reaction mixture and the diol component. The diol component is a long chain polyoxyethylene glycol optionally mixed with a low molecular weight polyoxyethylene glycol. A tough gel can be formed by mixing the polyurethane in a diol or triol and water solution. The tough gel can be used in burn and wound dressings, electroconductive pads, high slip materials and surgical implants. An optically clear gel can also be formed. Solutions and emulsions can be formed of the polymer and can be combined with fillers to form face creams and antiperspirants. A film can cover one side of the gel for burn and wound applications. The gel can be used in squeeze tubes and in spray cans in burn wound care dressings and industrial applications and in bags and containers for use in plastic surgery implants.
    Type: Grant
    Filed: August 14, 1996
    Date of Patent: March 17, 1998
    Assignee: Tyndale Plains-Hunter, Ltd.
    Inventors: Murray H. Reich, Ken Nelson, Jirina Kuzma
  • Patent number: 5723446
    Abstract: The present invention provides an enteral nutritional formulation that meets the nutrient requirements of intensive care patients who may have compromised absorption capacity. The present invention meets the unique nutrient needs of the patient that are generated due to tissue repair and healing requirements. To this end, in an embodiment the present invention provides a method for treating and/or providing nutritional support to intensive care patients comprising the steps of administering a therapeutically effective amount of a composition comprising: a protein source; a carbohydrate source; and a lipid source including a source of medium chain triglycerides, a source of omega-3 fatty acids, and a source of omega-6 fatty acids.
    Type: Grant
    Filed: July 17, 1996
    Date of Patent: March 3, 1998
    Assignee: Nestec Ltd.
    Inventors: Debora Gray, Nancy S. Schmelkin, John Alexander, David A. Mark, Diana Twyman
  • Patent number: 5720981
    Abstract: This invention provides a composition capable of stimulating growth and regeneration of epidermal cells. The composition comprises an aqueous, cell-free extract derived from epidermal cells.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: February 24, 1998
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventor: Magdalena Eisinger
  • Patent number: 5714472
    Abstract: The present invention provides an enteral nutritional formulation that meets the nutrient requirements of intensive care patients who may have compromised absorption capacity. The present invention meets the unique nutrient needs of the patient that are generated due to tissue repair and healing requirements. To this end, in an embodiment the present invention provides a method for providing nutritional support to intensive care patients comprising the steps of administering a therapeutically effective amount of a composition comprising: a protein source; a carbohydrate source; and a lipid source including a source of medium chain triglycerides, a source of omega-3 fatty acids, and a source of omega-6 fatty acids.
    Type: Grant
    Filed: September 20, 1995
    Date of Patent: February 3, 1998
    Assignee: Nestec Ltd.
    Inventors: Debora Gray, Nancy S. Schmelkin, John Alexander, David A. Mark, Diana Twyman
  • Patent number: 5709877
    Abstract: This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a natural, synthetic or semisynthetic polymer of hydrophilic nature, and their preparation process. These polysaccharide-matrix gels in highly hydrated self-supporting film form are suitable for use as covering and protection materials for cutaneous lesions and/or pathologies in that they are obtainable in self-supporting form in the desired thickness, are transparent, flexible, have good mechanical characteristics, are adaptable to the lesion surface without strongly adhering to it, and are permeable to gas but are impermeable to liquids and bacteria; one or more pharmacologically active substances can also be incorporated in the gel.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 20, 1998
    Assignee: Fidia S.p.A.
    Inventors: Francesco Della Valle, Alessandro Rastrelli, Gabriella Calderini, Aurelio Romeo
  • Patent number: 5681586
    Abstract: A pharmaceutical composition comprising an improved modified protein sol is used for treating and enhancing the healing of arthritis and cutaneous acne. Prior to being modified, a protein is solubilized and neutralized by an alkali solution containing a molar weight percent ratio of 95:5 KOH/NaOH. Neutralization is allowed to continue for about 5 minute, allowing for complete neutralization of the protein. The neutralized protein is then hydrolyzed by enzymatic digestion. The improved modified protein sol may be then mixed with stabilizing and preserving agents, such as polyvinyl pyrrolidone, if desired. Uses for the improved modified protein composition includes treatment of arthritis and cystic acne.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: October 28, 1997
    Inventor: Arthur L. Gordon
  • Patent number: 5674505
    Abstract: Vitamin B12 is used to stimulate heme oxygenase production. In turn, levels of the molecules 12(R)-HETE and 12(R)-DIHETE, which are arachidonic acid derivatives, are reduced. Various topical formulations containing vitamin B12, but no other vitamins, are described.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: October 7, 1997
    Assignee: Hemogen, Inc.
    Inventors: Richard D. Levere, Nadar G. Abraham, Michal L. Schwartzman, Michael W. Dunn
  • Patent number: 5674853
    Abstract: The present invention features saponin containing enteral formulations for treatment of infection and inflammation. These saponin containing formulations are particularly useful in conjunction with oils rich in .omega.3 polyunsaturated fatty acids such as fish oils and flax oil but also show benefits with .omega.6 rich oils such as borage oil, black currant seed oil, canola oil and rapeseed oil. These formulations may also contain a lignan from the sesamin family.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: October 7, 1997
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: R. Armour Forse, Sambasiva Chavali
  • Patent number: 5674912
    Abstract: The present invention pertains to therapeutic sunscreen-wound healing compositions useful to minimize and treat sunburn damage. The compositions comprise a therapeutically effective amount of (1) a sunscreen agent; (2) an anti-inflammatory; and, (3) a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic sunscreen-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic sunscreen-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: October 7, 1997
    Assignee: Warner-Lambert Company
    Inventor: Alain Martin
  • Patent number: 5670175
    Abstract: An ultrapure egg oil is prepared starting from dried and powdered avian or reptilian egg yolk by means of extraction with the aid of fat solvents, followed by two-step ageing, first at ambient temperature and then at a lowered temperature, separating off and centrifuging off the less viscous phase formed and again separating off the less viscous component. This component is, if appropriate repeatedly, mixed with demineralized water and heated, and, after cooling, the less viscous phase is separated off and again centrifuged, the less viscous component is again separated off and held at a lower temperature, the phases are again separated, and the less viscous component which has been separated off is recentrifuged.This again results in phase separation, the less viscous component which has been separated off being the end product which is a yellow to reddish, fluid oil which can be stored without preservatives.
    Type: Grant
    Filed: September 27, 1995
    Date of Patent: September 23, 1997
    Inventor: Werner C. Nawrocki
  • Patent number: 5658956
    Abstract: The present invention pertains to therapeutic bioadhesive-wound healing compositions useful for treating wounds and increasing the proliferation and resuscitation rate of mammalian cells. The compositions comprise a bioadhesive agent and a therapeutically effective amount of a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic bioadhesive-wound healing compositions may further comprise medicaments such as antiviral agents, antikeratolytic agents, anti-inflammatory agents, antifungal agents, antibacterial agents, immunostimulating agents, and the like. The bioadhesive-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the bioadhesive-wound healing compositions and the pharmaceutical products in which the compositions may be used.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: August 19, 1997
    Assignee: Warner-Lambert Company
    Inventors: Alain Martin, Sau-Hung S. Leung
  • Patent number: 5658957
    Abstract: This invention pertains to therapeutic immunostimulating-wound healing compositions. The compositions comprise a therapeutically effective amount of an immunostimulating agent and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic immunostimulating-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic immunostimulating-wound healing compositions and the pharmaceutical products in which the compositions may be used.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: August 19, 1997
    Assignee: Warner Lambert Company
    Inventor: Alain Martin
  • Patent number: 5653994
    Abstract: A method and composition is provided for treating burns, allergies, trauma or disease of the dermis, epidermis, mucous membranes and subcutaneous tissue, in particular the trauma caused by burns. The method includes applying an aqueous solution of Hydrogen Peroxide (H.sub.2 O.sub.2) and certain Aluminum salts of carboxylic acids to the trauma, assuring sufficient time of contact of the solution to the affected area of the skin to greatly enhance the healing process. Sufficient contact has been achieved by applying a bandage moistened with the solution to the area of the skin requiring treatment and keeping the bandage moistened for the term of the treatment. An adequate term of treatment has been measured in as little a time as repeated periods of minutes for a period of one day. Success has also been achieved by immersing the treatment area in the aqueous solution.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 5, 1997
    Inventors: Norman S. Schneider, Jakob Cherepakho, Elizabeth Cherepakho
  • Patent number: 5616619
    Abstract: A topical composition for treatment of skin burn, comprising salt and lemon juice, preferably in proportions sufficient to form a pasty composition. A method for treatment of skin burn using this topical composition is also disclosed.
    Type: Grant
    Filed: June 3, 1994
    Date of Patent: April 1, 1997
    Inventor: Dorothy E. Stofer
  • Patent number: 5614561
    Abstract: This invention pertains to therapeutic antihistamine-wound healing compositions. The compositions comprise a therapeutically effective amount of one or more antihistamine agents and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic antihistamine-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic antihistamine-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: March 25, 1997
    Assignee: Warner-Lambert Company
    Inventor: Alain Martin
  • Patent number: 5605687
    Abstract: Novel methods for the treatment of tissue damage resulting from cell membrane permeabilization due to electrical injury are disclosed. Such methods include treatment with a surface active copolymer which is herein shown to promote membrane repair. The administration of Poloxamer 188 is shown to reduce tissue inflammation and damage following electrical injury in vivo. Also disclosed are methods for the treatment of cell and tissue damage after electrical injury using a surface active copolymer in combination with a high energy phosphate compound capable of recharging cellular energy stores and potentiating cell repair and survival. Compositions comprising surface active copolymers for intravenous, intramuscular, and topical use are also disclosed, along with novel compositions comprising a combination of a surface active copolymer and a high energy phosphate compound.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 25, 1997
    Assignee: Arch Development Corporation
    Inventor: Raphael C. Lee
  • Patent number: 5602183
    Abstract: The present invention pertains to therapeutic dermatological-wound healing compositions useful to minimize and treat diaper dermatitis. The compositions comprise a therapeutically effective amount of a buffering agent to maintain the pH of the dermatitis in a range from about 5 to about 8, an anti-inflammatory agent, and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; (c) a mixture of saturated and unsaturated fatty acids. The therapeutic dermatological-wound healing compositions may be utilized in a wide variety of topical pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic dermatological-wound healing compositions and the pharmaceutical products in which the compositions may be used.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: February 11, 1997
    Assignee: Warner-Lambert Company
    Inventors: Alain Martin, Ammunje S. Nayak
  • Patent number: 5589480
    Abstract: The present invention is directed to a method and apparatus for the topical application of opioid analgesic drugs such as morphine. Specifically, the present invention relates to a topical application of the opioid drug and specifically a morphine sulphate in a diluted solution to produce an analgesic effect in a localized area and typically in a localized inflamed area and without a transdermal migration of the opioid drug into the blood stream.
    Type: Grant
    Filed: August 17, 1994
    Date of Patent: December 31, 1996
    Inventors: George F. Elkhoury, Christoph Stein
  • Patent number: 5565189
    Abstract: A low-sensitizing wound cleanser product is provided for use in rinsing contaminants from injuries. The cleanser includes a combination of specially selected non-irritating ingredients that include a water and aloe vera carrier portion, an emollient portion, a hydroxyquinoline antimicrobial portion, a surfactant portion, and a preservative portion.
    Type: Grant
    Filed: February 3, 1995
    Date of Patent: October 15, 1996
    Inventor: Gerit D. Mulder
  • Patent number: 5543148
    Abstract: The invention presented relates to a stick delivery system for the topical application of a treatment agent. The inventive stick delivery system includes a solvent such as a polyhydric alcohol; a gelling agent which can be an alkali metal stearate, an alkali metal palmitate or mixtures thereof; and a treatment agent selected from the group consisting of an anesthetic, an antihistamine, an anti-inflammatory agent, an antifungal agent, or mixtures thereof.
    Type: Grant
    Filed: July 12, 1994
    Date of Patent: August 6, 1996
    Assignee: Combe, Incorporated
    Inventor: Herbert Lapidus
  • Patent number: 5538738
    Abstract: The invention relates to the use of free radical-reactive cross-linker components based on olefinically unsaturated esters of lower hydroxycarboxylic acids and/or oligomers thereof for modifying depot materials, and especially retard systems, which contain medicinal and/or biological valuable materials in admixture with a carrier material in a sustained release form. The cross-linkers are present as polymer compounds in the application form of the retard system and may be provided in the retard system or depot material to be applied in a largely homogeneous as well as in a non-uniform distribution. The invention also relates to retard systems which contain medicinal and/or biological valuable materials and have been based on oligomer and/or polymer compounds of lower hydroxycarboxylic acids as carrier materials providing a sustained release of the active substance.
    Type: Grant
    Filed: October 18, 1993
    Date of Patent: July 23, 1996
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Wolfgang Ritter, Rudolf Lehmann, Rainer Sorg
  • Patent number: 5538740
    Abstract: An active ingredient for a therapeutic or cosmetic composition is obtained from live gastropoda (e.g., snails) which are physically stimulated (e.g., by centrifuging) to cause secretion of a fluid which is then centrifuged and filtered. Preferably the gastropoda are fasted prior to the physical stimulation. The therapeutic or cosmetic compositions contain about 0.1-30% of the active ingredient which is a mixture of amino acids and atoxic substances, an effective amount of an excipient preferred for use with biologically active ingredients, and other conventional ingredients provided they do not affect the stability and/or the activity. The therapeutic composition, in the form of a topical cream, can be used to treat various types of burns, dermatitis, eczema, diaper rash, and difficult to heal wounds. It can also be used to prevent skin cancer and radiodermatitis. The cosmetic composition can be used as hand and face creams, an anti-wrinkle cream, a sunscreen cream, a moisturizing lotion, and a deodorant.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: July 23, 1996
    Assignee: Atherton Investments, Ltd.
    Inventor: Rafael Abad
  • Patent number: 5532275
    Abstract: A novel method of treating wounds has been discovered that is based on the system and/or topically administration of an effective amount, of para-amino benzoic acid or its derivatives, to a patient who has a wound, the healing of the wound will be promoted and scar formation will be reduced. In addition, it has been discovered that by systemically and/or topically administering an effective amount of para-amino benzoic acid or its derivatives, to a patient who has scar tissue or keloids, the scar tissue and/or keloid tissue will regress and/or soften to allow the skin in the area of the scar or keloid to become more flexible.
    Type: Grant
    Filed: December 7, 1994
    Date of Patent: July 2, 1996
    Assignee: Andrx Pharmaceuticals, Inc.
    Inventor: Martin Grumet
  • Patent number: 5525593
    Abstract: The use of IGF-II for preparing a medicament for the regeneration of muscle tissue; and methods for medical treatment for the purpose of regenerating muscle tissue, for minimizing scar formation during healing of a wound or for preventing undesired tissue adhesion after injury, such as after surgery.
    Type: Grant
    Filed: January 26, 1994
    Date of Patent: June 11, 1996
    Assignee: Pharmacia AB
    Inventors: Mats Lake, Eva Jennische
  • Patent number: 5523093
    Abstract: This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a natural, synthetic or semisynthetic polymer of hydrophilic nature, and their preparation process. These polysaccharide-matrix gels in highly hydrated self-supporting film form are suitable for use as covering and protection materials for cutaneous lesions and/or pathologies in that they are obtainable in self-supporting form in the desired thickness, are transparent, flexible, have good mechanical characteristics, are adaptable to the lesion surface without strongly adhering to it, and are permeable to gas but are impermeable to liquids and bacteria; one or more pharmacologically active substances can also be incorporated in the gel.
    Type: Grant
    Filed: May 30, 1991
    Date of Patent: June 4, 1996
    Assignee: Fidia, S.p.A.
    Inventors: Francesco Della Valle, Alessandro Rastrelli, Gabriella Calderini, Aurelio Romeo
  • Patent number: 5518730
    Abstract: Biodegradable controlled release delivery systems using melt-spun biodegradable polymers as carriers for bio-effecting agents such as pharmaceutical actives are disclosed. Oral dosage forms as well as implants are described.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: May 21, 1996
    Assignee: Fuisz Technologies Ltd.
    Inventor: Richard C. Fuisz
  • Patent number: 5514657
    Abstract: A topical antibacterial preparation for treating infected wounds and for advancing their healing comprises silver sulfadiazine (SSD) and collagen, in which the w/w ratio of collagen to SSD ranges from 4/1 to 200/1. The concentration of the SSD is preferably from 0.5% to 2.5%, advantageously 1%. The collagen is advantageously native collagen, which may be acid soluble or insoluble, or mixtures thereof. The preparation may comprise an inert excipient, e.g. SiO.sub.2, or blood plasma components, peptides, carbohydrates.
    Type: Grant
    Filed: November 8, 1994
    Date of Patent: May 7, 1996
    Assignee: Yissum Research Development Company of the Hebrew University
    Inventors: Shmuel Shoshan, David Marcos
  • Patent number: 5494896
    Abstract: The present invention provides methods of preventing or treating conditions associated with burn injuries by administering bactericidal/permeability-increasing (BPI) protein product.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: February 27, 1996
    Assignee: XOMA Corporation
    Inventor: John F. Hansbrough
  • Patent number: 5470568
    Abstract: Novel methods for prophylaxis and treatment of tissue damage resulting from cell membrane permeabilization are disclosed. Compositions comprising a surface active copolymer are employed to prevent permeabilization or to promote membrane repair. Methods for enhancement of cell survival following membrane permeabilization in vitro are also disclosed, along with methods for increasing the efficacy of transfection of cells with foreign exogenous macromolecules, in particular DNA, also involving treatment of permeabilized cells with a surface active copolymer. Also disclosed are novel methods for prophylaxis and treatment of tissue damage, and for enhancement of cell survival and transfection efficacy, using a surface active copolymer in combination with high energy phosphate compounds which are capable of recharging cellular energy stores and thereby potentiating cell repair and survival.
    Type: Grant
    Filed: February 13, 1992
    Date of Patent: November 28, 1995
    Assignee: Arch Development Corporation
    Inventor: Raphael C. Lee
  • Patent number: 5443821
    Abstract: Novel phenol compounds of the formula: ##STR1## wherein R.sub.1 is an alkyl substituent of from 8 to 18 carbon atoms, R is an ethyl or propyl substituent, and n is from about 50 to 200.These compounds as well as certain other similarly alkoxylated compounds, for example, a compound of the formula: ##STR2## wherein R.sub.2 and R.sub.3 are each, independently an alkyl substituent of 8 to 15 carbon atoms, R is an ethyl or propyl substituent, and n is from about 50 to 200, may be used in sodium stearate based stick gels to enhance transparency, minimize syneresis and/or increase the setting point of the gel.
    Type: Grant
    Filed: November 10, 1992
    Date of Patent: August 22, 1995
    Assignee: Application Chemicals, Inc.
    Inventors: Ronald J. Smith, Steele Elmi
  • Patent number: 5432191
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: July 30, 1993
    Date of Patent: July 11, 1995
    Assignee: The Center for Innovative Technology
    Inventors: Donald J. Abraham, Mona Mahran, Ahmed Mehanna, Ramnarayan Randad, Gajanan S. Joshi, Jayashree Panikker
  • Patent number: 5427801
    Abstract: An antifungal agent for the treatment of skin disease such as athlete's foot, ringworm and tinea caused by dermatophytes, eczema, tinea or various fungi, which comprises a 100 weight % of detergent solution including 0.01-40 weight % of sodium hypochlorite, 0.01-30 weight % of sodium sulfite, 0.01-40 weight % of sodium nitrite, 0.01-40 weight % of sodium chlorate, 0.01-40 weight % of potassium chlorate, 0.001-35 weight % of hydrogen peroxide, 0.01-40 weight % of ozone water, 0.01-40 weight % of sodium nitrite, 0.01-40 weight % of potassium nitrite, 0.001-1 weight % of nonionic surface active agent and 1-90 weight % of water.It is characterized in that trichophyton, eczema or various fungi in the dermis or deep layer are allured by oxygen contained in the antifungal agent to or near the surface of the skin for easy sterilization by oxidation, reduction, bleaching and fungicidal activity.A ligand agent is also efficacious for the treatment of a burn of the skin and of stiffness in the shoulder.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: June 27, 1995
    Assignee: Japan Lotion Company
    Inventor: Kazutoyo Uehara
  • Patent number: 5397778
    Abstract: The present invention features saponin containing enteral formulations for treatment of infection and inflammation. These saponin containing formulations are particularly useful in conjunction with oils rich in .omega.3 polyunsaturated fatty acids such as fish oils and flax oil but also show benefits with .omega.6 rich oils such as borage oil, black currant seed oil, canola oil and rapeseed oil. These formulations may also contain a lignan from the sesamin family.
    Type: Grant
    Filed: April 15, 1994
    Date of Patent: March 14, 1995
    Assignee: New England Deaconess Hospital Corporation
    Inventors: R. Armour Forse, Sambasiva Chavali