Abstract: Nontoxic, germicide, and healing composition are disclosed comprising propylene glycol, allantoin and water. The composition may also include ascorbic acid and/or a member selected from the group consisting of chlorophyll, carotene, and mixtures thereof.

Abstract: The regeneration of animal tissues by intramuscular injections containing a substituted ethylamine in combination with a macromolecular substance for the purpose of intravascular transportation and or inhibition of hydrolysis of the compound after injection. The ethylamine moiety is selected from the group consisting of lidocaine, butethamine, chloroprocaine, dibucaine, hexylcaine, mepivacaine, piperocaine, benoxinate, naepaine, phenocaine, cyclomethycaine, proparacaine, pramoxine, tetracaine, dimethisoquin, procaine and 2-(4 imidazolyethylamine) or histamine and diphenhydramine. The macromolecule is selected from the group consisting of polyvinylpyrollidone, methyl cellulose, dextran, gelatin and polyoxyethylene sorbitan mono-oleate.

Abstract: A novel class of mercapto acyl-carnitines is disclosed, wherein the mercapto acyl radical is the radical of saturated mercapto acids having from 2 to 10 carbon atoms. These mercapto acyl-carnitines are prepared, e.g., by first preparing the corresponding halogen acyl-carnitine and then substituting therein, by nucleophylic substitution, the --SH group for the halogen atom.These mercapto acyl-carnitines are useful therapeutic agents, e.g., for the treatment of intoxications and burns and as mucolytic agents. Dithio diacyl carnitines and hydrochloride salts thereof, which are intermediates, are also disclosed.

Abstract: A novel class of esters of mercapto acyl-carnitines is disclosed, wherein the mercapto acyl radical is the radical of saturated mercapto acids having from 2 to 10 carbon atoms. These esters of mercapto acyl-carnitines are prepared e.g. by first preparing the corresponding ester of halogen acyl-carnitine and then substituting therein, by nucleophylic substitution, the --SH group for the halogen atom.These esters of mercapto acyl-carnitines are useful therapeutic agents, e.g. for the treatment of intoxications and burns, and as mucolytic agents.

Abstract: A novel compound bis-(N,N-dimethyl-N-carbodecyloxymethyl-N-ethyleneammonium)-sulphide dichloride of the formula ##STR1## A method for preparing said novel compound comprising quaternization of bis-(.beta.-dimethylaminoethyl)-sulphide with monochloroacetic acid decyl ester, molar ratio of said reagents being not more than 1:2.A chemotherapeutic antimicrobial preparation comprising said novel compound as an active principle in combination with a pharmaceutical carrier.A plant growth regulator in the form of an aqueous solution of said novel compound in a concentration of from 0.0001 to 0.1 wt. %.

Abstract: Compounds having the formula ##STR1## in which R is C.sub.3 -C.sub.5 alkyl or C.sub.3 -C.sub.5 alkenyl and n is an integer from 1 to 3, are effective to repel insects.

Abstract: A pressurized shaving cream composition in an aerosol container and adapted to form a spray upon release of pressure therefrom which composition is a liquid inside the container and forms a gel on contact with living tissue comprising water, volatile solvent, propellant and a polyoxyethylene-polyoxypropylene copolymer. The preferred composition also includes a volatile solvent and may advantageously include a treatment agent and conventional additives.

Abstract: A pressurized composition in an aerosol container and adapted to form a spray upon release of pressure therefrom which composition is a liquid inside the container and forms a gel on contact with living tissue comprising water, propellant and a polyoxyethylene-polyoxybutylene copolymer. The preferred composition also includes a volatile solvent and may advantageously include a skin treating agent, and conventional adjuvants.

Abstract: Compositions containing gelatin, hydrogen peroxide, ammonium hydroxide, thioglycolic acid, and a lower alkanol as the principal ingredients are useful to promote the growth of dermal and epidermal tissue.

Abstract: Treatment of skin wounds with starch hydrolysate composition can be improved by irrigating the wound with a buffered salt solution having a pH in the range of approximately 6-7.8 prior to application of the starch hydrolysate composition. Additionally, the treatment can include further irrigation with amino acid solution. A preferred starch hydrolysate composition is compounded to include alphaketoglutaric acid or a salt thereof.

Abstract: Water soluble hydrogels of alkali metal alginate and glycerine have been found to be excellent wound dressings. The gels dry to an adherent, non-toxic pliable protective film which can be removed by water-washing when desired. The gels are also compatible with medicaments and hence can serve as vehicles or carriers for medicament application to wounds as well as a protective cover.

Abstract: Water soluble hydrogels of alkali metal alginate and glycerin containing 0.01 to 1% cupric (copper) sulfate pentahydrate or silver salts such as silver acetate, silver lactate monohydrate and silver nitrate have been found to be excellent wound dressing treatment composition for white phosphorus burns.Cupric sulfate pentahydrate or silver salts such as silver acetate, silver lactate monohydrate and silver nitrate in the gel reacts with the particles of white phosphorus to form a coating around said particles thus rendering them unable to cause further burn injury to the skin. The gels dry to an adherent, non-toxic pliable protective film which can be removed by water-washing when desired. The gels are also compatible with other medicaments and hence can serve as vehicles or carriers for medicament application to wounds as well as a protective cover.

Abstract: Silver ion gel compositions containing a polyoxybutylene-polyoxyethylene block copolymer that maintain their gel characteristics at temperatures below 20.degree. C. These gel compositions may be used to treat burn wounds and superficial ulcers.

Abstract: Victims suffering certain types of wounds are treated by contacting the wound with a substantially fluorinated carbon material or a mono- or di-brominated derivative thereof containing molecular oxygen.

Abstract: A method for the drying and diminution of cutaneous and mucosal lesions and the relief of the sensations of burning, pain and itching of cutaneous and mucosal surfaces is discussed. The process comprises the step of topically applying to the situs of the condition being treated, a composition consisting essentially of (A) a compound selected from the group consisting of: (1) aminocaproic acid, (2) a compound of the formula 4NH.sub.2 CH.sub.2 (CH.sub.2).sub.4 COOH.CaX.sub.2 wherein X is chloride or bromide, or (3) mixtures thereof, and (B) an inert, pharmaceutically acceptable carrier.

Abstract: A biological dressing for open wounds, especially large-area burn wounds, is formed by removing free hemoglobin from a red blood cell concentrate which is subjected to hemolysis. The product thus contains the stroma, subcellular elements and precipitated protein from the human red blood corpuscle concentrate freed from the hemoglobin and can be used in a pulverulant or layer form with, if desired, an appropriate support.

Abstract: Solid, stick-type cosmetic compositions consist essentially of from about 1 to about 30 parts by weight of sodium stearate, 100 parts by weight of water and an "active" material intended to be applied to the skin. The composition also preferably contains a polyhydroxyl compound, such as a glycol or a polyglycol in an amount of from about 0.5 to about 10 weight percent. The addition of up to about 5 weight percent sodium chloride reduces the "syneresis" effect upon storing the compositions at low or high temperature, and increases the setting point of the composition. The compositions are useful as deodorant sticks, perfume sticks, sun sticks, hand lotion sticks, talc sticks, pigment sticks and insect repellant sticks.

Abstract: This invention, improved the means of making the ointment or the emulsion and others which traditionally used for Burn and Frostbite, is for a new method of making the burn and frostbite plaster and it provides with the most safety.

Abstract: In a process for extracting embryonic calf skin which includes initially grinding the calf skin, extracting the same, separating the resulting extract and lyophilizing the separated extract, the extraction stage is carried out in an extraction medium comprising an aqueous solution having an acid pH, at a temperature between 60.degree.-75.degree. C., for a period of at least 3 hours. The resulting extract which exhibits cicatrisive activity is employed in cosmetic and pharmaceutical compositions.

Abstract: An agar gel topical dressing for coating a burn area or other area of skin impairment is prepared by heating and agitating a mixture of agar, diethylene glycol and water to solubilize the agar. The resulting solution, upon cooling to its gelation temperature, is converted to a thermally reversible agar gel. Application of the agar gel as a burn coating is undertaken by heating the gel to obtain a sol, applying the sol to the burn area at a tissue compatible temperature, and allowing the sol to cool and set in the form of a gel.

Abstract: The present invention provides a covering material consisting essentially of a hydrophilic, water insoluble polymer (component A), a high boiling plasticizer and/or organic solvent (component B) for said component A, and an aqueous liquid (component C). Said covering material is useful as a protective covering material for forming a film or coat on the skin and/or wound surface in the treatment of burn. The material is characterized in that film or coat formation on the skin and/or wound surface can be realized in a short time.

Abstract: A method for preventing deleterious effects of solar radiation by applying to human skin an effective amount of a composition or formulation comprising para-aminobenzoic acid, calcium-d-pantothenate, and a tocopherol compound, and desirably a gelling agent, is disclosed, along with methods of applying such compositions for use as a sunscreening agent, or for the treatment of skin ailments, particularly burns. To such compositions, a waxy extract of Kava may be included as a local anesthetic, along with a suitable carrier, such as a mixture of light unsaturated oils with stimulant agents.

Abstract: Solid, stick-type cosmetic compositions consist essentially of from about 1 to about 30 parts by weight of sodium stearate, 100 parts by weight of water and an "active" material intended to be applied to the skin. The composition also preferably contains a polyhydroxyl compound, such as a glycol or a polyglycol in an amount of from about 0.5 to about 10 weight percent. The compositions are useful as deodorant sticks, perfume sticks, sun sticks, hand lotion sticks, talc sticks, pigment sticks and insect repellant sticks.

Abstract: A method for the treatment of burns such as second and third degree burns to human skin. The method involves the topical application to the burn area of an oil derived from the yolk of an egg such as an avian egg. The raw egg is subjected to a heat treatment whereby the egg yolk oil may be drawn off and used neat or with other pharmaceutically acceptable components.

Abstract: A method for treating skin burns in mammals where hot, molten organic substances have been deposited on, and are adhering to and aggravating, burned skin areas includes quickly but gently applying sufficient volatile cooling solvent to the affected areas to remove such adhering substances from these areas without further substantial injury thereto, while cooling the areas.

Abstract: Composition and method for emergency treatment of burn injuries. A solution f poly-.epsilon.-caprolactone and triethyl citrate plasticizer or triacetin plasticizer in a volatile solvent such as methylene chloride is applied to the burn area by spraying or swabbing. Upon evaporation of the solvent a flexible film of the plasticized polymer is left to serve as a partial barrier to water loss.

Abstract: Compositions and process employing guanidine compounds and peroxide compounds for treatment of acne and other skin lesions by topical application.

Abstract: A composition active with respect to erythema solare, which comprises a mixture of tinctures of Apis mellifica at a dilution of from 4.degree. CH to 15.degree. CH and Calendula at a dilution of from a third decimal to 9.degree. CH.

Abstract: A skin treatment composition or formulation comprising para-aminobenzoic acid, calcium-d-pantothenate, and a tocopherol compound, and desirably a gelling agent, is disclosed, along with methods of applying such compositions for use as a sunscreening agent, or for the treatment of skin ailments, particularly burns. To such compositions, a waxy extract of Kava may be included as a local anesthetic, along with a suitable carrier, such as a mixture of light unsaturated oils with stimulant agents.

Abstract: Compositions for the treatment of inflammation of the skin containing from 0.01% to 10% by weight of an alkoxybenzoic acid ester of the formula ##STR1## where R.sub.1 is alkyl having 1 to 6 carbon atoms, and R.sub.2 is alkyl having 1 to 8 carbon atoms, cyclohexyl, phenyl or benzyl, as inflammation inhibitor; as well as the method of skin treatment.

Abstract: Compositions especially adapted for use as vehicles for the topical administration of an anti-inflammatory amount of acetylsalicylic acid to inflamed tissue and methods for using same are provided.

Abstract: Method and composition for the chemexfoliation (chemical exfoliation) of seborrheic keratosis and related conditions, the composition consisting essentially of an alkali metal or ammonium phenate, a monohydric alcohol, a polyhydric alcohol humectant and a gelling agent.

Abstract: 1,2,3,4,5,6-Hexahydro-3-lower alkenyl-6-(R.sup.1)-11-(R.sup.2)-8-hydroxy-2,6-methano-3-benzazocines, wherein R.sup.1 and R.sup.2 are hydrogen or lower alkyl, and certain ethers and esters thereof, are obtained from analogous 3-unsubstituted compounds. The products have pharmacodynamic activity and are useful as antagonists of strong analgesic agents, such as morphine and meperidine, and are useful in humans as agents for producing analgesia.

Abstract: Water-soluble cerium salts and compositions containing the same have been found to be useful in the treatment of burns, such as by the application of an aqueous solution of a water-soluble cerium salt to the burn surface. Particularly useful in burn therapy is the combination of a water-soluble cerium salt, such as cerous nitrate, with silver sulfadiazine.

Abstract: A method for the generation of gelatin-based stabilized foams by passing a stream of air or other gas through a composition of the gelatin, an anionic surface-active agent and a water soluble ferrous salt. The resulting foams have a relatively long life term.

Abstract: Cerium sulfadiazine and compositions containing a cerium sulfadiazine, particularly cerous sulfadiazine [Ce(SD).sub.3 ] wherein SD represents the sulfadiazine moiety, have been found to be useful in the treatment of burns. Cerous sulfadiazine is prepared by reacting an aqueous solution of sodium sulfadiazine with an aqueous solution of a cerous salt, such as cerous nitrate or cerous chloride. The resulting cerous sulfadiazine is formed as a white precipitate. The precipitated cerous sulfadiazine, such as made by reacting cerous nitrate with sodium sulfadiazine, upon washing and drying has a melting point of 248.degree.-255.degree. C.

Abstract: Zinc is essential in the complex process of wound healing. Zinc sulfadiazine promotes wound healing and controls infection. When taken into the body, such as by topical application to a wound surface, zinc sulfadiazine dissolves and its dissociation achieves a replacement of zinc lost in the body fluids, such as in the urine, after thermal or other trauma. Although both zinc sulfadiazine and silver sulfadiazine each effectively controls infection and enhances healing in burn wounds, the combination of zinc sulfadiazine and silver sulfadiazine, particularly in a single medicament, possesses enhanced efficacy.

Abstract: Alkyl esters of aminosalicylic acid, said alkyl group having from 1 to 18 carbon atoms in chain length; alkenyl esters of aminosalicylic acid, said alkenyl group selected from the group consisting of vinyl, allyl, undecenyl, oleyl and linolenyl groups, and cyclic esters of aminosalicylic acid, said cyclic group being the cyclohexyl, phenyl and menthyl groups, having ultra-violet screening properties to absorb light rays within the wave-length range of 2950 A. to 3200 A. while transmitting the light rays beyond the 3200 A. range to permit the desirable tanning of the skin without solar burn. The respective esters of aminosalicylic acid are prepared by the reduction of the appropriate nitro-salicylic acid ester with Raney nickel and hydrogen in the presence of ethyl acetate. The respective esters are obtained as oils or solid crystalline substances and are soluble in alcohols, chloroform, acetone and benzene but insoluble in water. The ultra-violet absorption spectra for the respective compounds are described.

Abstract: Soluble, hydrophilic polymers suitable for medical use and as blood plasma substitutes comprising low molecular weight polymer derived from at least one monomer of an acrylamide type material or a mono-ester of an acrylic type acid and a glycol which is condensed with bifunctional compounds to form a condensation polymer having increased molecular weight and enzymatically cleavable cross-links. The hydrophilic polymer is produced by polymerizing the acrylamide type material or mono-ester mentioned above to form a low molecular weight polymer which is then condensed with a bifunctional compound to form a high molecular weight condensation polymer having enzymatically cleavable cross-links.

Abstract: An aerosol package containing a foam-forming, oil-in-water emulsion and a propellant system consisting essentially of nitrous oxide and a liquefied, normally gaseous hydrocarbon or halogenated hydrocarbon is described. The emulsion upon being dispensed is a unique, rich, shiny, creamy foam having good foam density and stiffness characteristics.

Abstract: A wound dressing of the type having a water soluble plasma soluble self-supporting flexible body and which may be aerated and foamed. The flexible body is self-adhering to the wound tissues and forms an artificial eschar with the moist elements at the situs of the wound. The flexible body is formed primarily from a water soluble dextran polymer.

Abstract: An improved topical composition for application to skin effected by seborrheic keratosis so as to provide a superficial slough of the epidermis, the composition containing an inhibited phenol, preferably potassium phenolate, a salicylate, a zinc compound and resorcinol, the active ingredients being dissolved in a non-aqueous solvent which includes a hydrophilic non-toxic lower aliphatic alcohol, the amount of phenolate present being generally lower than the amount of phenolate in comparable compositions.

Abstract: A method and a composition for treating and remedying the consequences of burns, scalds and other skin affections resulting in an acidose. An aqueous buffer solution having a pH value of 8-10, preferably 8.5-9, is applied to the affected skin areas, immediately or very soon after the burning, scalding or other affection has taken place, and the application is, if necessary, repeated or continued. Skin which has been treated in this manner does not undergo the more or less profound blistering and damaging which is otherwise inevitable after burning or scalding. The composition preferably comprises a base, a surface-active agent and a fatty acid.

Abstract: This invention relates to chemotherapeutic compositions and methods for topically treating traumatic, diseased and degenerative skin disorders.One of the invention compositions comprises abietic acid and .alpha.-tocopherol contained in a pharmaceutically acceptable carrier. One or more of the invention compositions are suitable for the alleviation of severe burn injuries, and in the treatment of other skin disorders such as diabetic ulcers, decubitus ulcers, gangrene, abrasions, lacerations, puncture wounds, localized infections, and the like.

Abstract: A preparation and a method are described for emergency, interim treatment extensive burn injuries, e.g., flash burns, to external portions of a person. A solution of the polymer poly-.epsilon.-caprolactone is a volatile solvent, such as acetone or tetrahydrofuran, is applied to the burn area by spraying or swabbing, so that upon evaporation of the solvent a film of the polymer is left to serve as a barrier to insensible water loss.