Abstract: Disclosed herein, the invention pertains to methods and compositions that find use in diagnostic, prognostic and characterization of neoplasia samples based on the ability of a neoplasia sample to cleave a MTS molecule of the present invention. In some embodiments, a MTS molecule disclosed herein has the formula (A-X-B-C), wherein A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and C is a detectable moiety.

Abstract: A resist material and methods using the resist material are disclosed herein. An exemplary method includes forming a resist layer over a substrate, wherein the resist layer includes a polymer, a photoacid generator, an electron acceptor, and a photodegradable base; performing an exposure process that exposes portions of the resist layer with radiation, wherein the photodegradable base is depleted in the exposed portions of the resist layer during the exposure process; and performing an developing process on the resist layer.

Abstract: A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. Cleavage of X allows separation of A from B, unmasking the normal ability of the basic amino acids in B to drag cargo C into cells near the cleavage event. X is cleaved extracellularly, preferably under physiological conditions. D-amino acids are preferred for the A and B portions, to minimize immunogenicity and nonspecific cleavage by background peptidases or proteases.

Abstract: The present invention provides an optical recording material allows for obtaining excellent recording signal properties even at high-speed recording and is excellent in durability in both a single-sided single layer optical recording medium and a single-sided two-layer optical recording medium having a first recording layer and a second recording layer. The optical recording material contains a cyanine compound having a specific structure and a squarylium compound as dyes for optical recording layers.

Abstract: According to one embodiment, a write-once type information storage medium comprises an organic dye based recording material having sensitivity at a wavelength of 405 nm and at a recording wavelength in the range of 600 nm to 700 nm, wherein, when absorbance of a maximum absorption wavelength in the vicinity of 405 nm is defined as 1, the absorbance is 5% or more at any wavelength in the range of 600 nm to 700 nm.

Abstract: A method for fabricating an integrated circuit device is disclosed. The method includes providing a substrate; forming a first material layer over the substrate; forming a second material layer over the first material layer, wherein the second material layer comprises a photodegradable base material; and exposing at least a portion of the second material layer.

Abstract: An optical recording medium having a substrate and an optical recording layer on the substrate. The optical recording layer is formed of an optical recording material containing at least one heterocyclic compound represented by general formula (I): wherein Z1 represents oxygen, sulfur, —CR5R6—, etc. (R5 and R6 are each a substituent, e.g., an alkyl group or an aralkyl group, or are taken together to form a ring); R1 and R2 each represent hydrogen, etc.; R3 and R4 each represent an alkyl group having 1 to 8 carbon atoms or are taken together to form a heterocyclic ring having no multiple bond; Y1 represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a metallocene substituent, etc.; Anq? represents a q-valent anion; q represents 1 or 2; p represents a number necessary to neutralize an electric charge; and n represents a number of 1 to 4.

Abstract: According to one embodiment, a write-once type information storage medium comprises an organic dye based recording material having sensitivity at a wavelength of 405 nm and at a recording wavelength in the range of 600 nm to 700 nm, wherein, when absorbance of a maximum absorption wavelength in the vicinity of 405 nm is defined as 1, the absorbance is 5% or more at any wavelength in the range of 600 nm to 700 nm.

Abstract: A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. Cleavage of X allows separation of A from B, unmasking the normal ability of the basic amino acids in B to drag cargo C into cells near the cleavage event. X is cleaved extracellularly, preferably under physiological conditions. D-amino acids are preferred for the A and B portions, to minimize immunogenicity and nonspecific cleavage by background peptidases or proteases.

Abstract: A bisstyryl compound. The bisstyryl compound has formula (I): wherein Z1 and Z2 are benzene, naphthalene, or heterocyclic ring, R1 is H, C1-5 alkyl, hydroxyl, halogen atoms, or alkoxy, R2 is H, halogen atoms, C1-5 alkyl, nitro, ester, carboxyl, sulfo, sulfonamide, sulfuric ester, amide, C1-3 alkoxy, amino, alkylamino, cyano, C1-6 alkylsulfonyl, or C2-7 alkoxy carbonyl, R3, R4, R5, and R6 are H, halogen atoms, alkyl, aralkyl, or heterocyclic ring containing O, S, or N, or R3 and R4 are joined to a nitrogen atom or R5 and R6 are joined together to form a ring, R7 and R8 are H or alkyl, W is nitrogen with or without Z1 and Z2 or aromatic group without Z1 and Z2, Y is carbon, oxygen, sulfur, selenium, —NR, or —C(CH3)2, m is 1-3, n is 1-18, and X1 and X2 are anionic groups or anionic organometallic complexes.

Abstract: A bis(indolestyryl) compound. The bis(indolestyryl) compound has formula (I): wherein A and B comprise benzene, naphthalene, or heterocyclic ring containing O, S, or N, R1 and R1? are H, halogen, C1-5 alkyl, nitro, ester, carboxyl, sulfo, sulfonamide, amide, sulfo ester, C1-3 alkoxy, amino, alkylamino, cyano, C1-6 alkylsulfonyl, or C2-7 alkoxy carbonyl, R2, R2?, R3, and R3? comprise H, C1-6 alkyl, C6-18 aryl, C2-6 alkenyl, C3-6 cycloalkenyl, or C3-6 cycloalkyl, R4 is H, C1-5 alkyl, hydroxyl, halogen, or alkoxy, R5 and R5? comprise H, halogen, C1-5 alkyl, nitro, C1-3 alkoxy, amino, cyano, C1-6 alkylsulfonyl, or C2-7 alkoxy carbonyl, W comprises oxygen, sulfur, selenium, —NR, or —C(CH3)2, n is 1˜18 and Z1 and Z2 are different and comprise an anion or an anionic organometallic complex with +1 or +2 valence, wherein R bonded to nitrogen is C1-4 alkyl.

Abstract: The azo-metal chelate dye of the present invention is formed, for example, from zinc (divalent) as a center metal ion and an azo compound bonded with a coupler component having an amino group and a fluorine-substituted alkylsulfonylamino group subjected to condensed ring-formation to have a 1,3,4-thiazole ring as a diazo component.

Abstract: An optical information recording medium including a substrate in which at least one of a groove and a pit is formed; a recording layer located overlying the substrate and including a dye; and a reflection layer located overlying the recording layer, wherein the optical information recording medium has an absorbance curve with an absorbance L of from 10 to 40% against light having a wavelength ? of from 645 nm to 670 nm, a ratio (Lmax/Lmin) of a maximum absorbance Lmax of the absorbance curve to a minimum absorbance Lmin of from 1.0 to 2.0 at the wavelength range of from 645 nm to 670 nm, and a reflectance of from 45 to 85% against the light having a wavelength ? of from 645 nm to 670 nm.

Abstract: A recording medium comprises a substrate and a recording layer overlaid on the substrate. The recording layer comprises a material, which has properties such that, when recording light having a predetermined wavelength ?1 is irradiated to the material, the material is capable of being caused to change into a fluorescent material and such that, when excitation light having a wavelength ?2 is then irradiated to the thus formed fluorescent material, the fluorescent material is capable of being caused to produce fluorescence. The wavelength ?1 of the recording light and the wavelength ?2 of the excitation light may be identical or different. The substrate may be constituted of a material having properties such that, when the excitation light is irradiated to the material, the material does not produce fluorescence having a wavelength identical with the wavelength of the fluorescence produced by the fluorescent material.

Abstract: The present invention provides styryl dyes which have absorption maxima at a wavelength of 400 nm or less and are sensitive to a laser beam with a wavelength of 450 nm or less, light absorbents and optical recording media which comprise the styryl dyes, and a process for producing the styryl dyes which comprises reacting with an aldehyde compound a quaternary ammonium salt of nitrogen atom containing heterocyclic compound having an active methyl or active methylene group.

Abstract: Disclosed is an optical information recording medium comprising a substrate having provided thereon a recording layer capable of recording information by laser beam irradiation, wherein the recording layer contains at least one compound represented by the following general formula (I): The symbols in the formula (I) are defined in the specification. Also disclosed is a method for recording optical information using the optical information recording medium.

Abstract: A composition for an optical film comprising a stabilized cyanine dye and a quencher compound, wherein the stabilized cyanine dye comprises a cation and a quencher anion, and the cation is selected from the group consisting of compounds of the following formulae (I) to (III): wherein each of rings A and A? which are independent of each other, is a benzene ring, a naphthalene ring or a pyridine ring, each of R1 and R1? which are independent of each other, is a halogen atom, a nitro group, a cyano group, a C6-30 aryl group, a C1-8 alkyl group or a C1-8 alkoxy group, each of R2, R3 and R4 which are independent of one another, is a hydrogen atom, a halogen atom, a cyano group, a C6-30 aryl group, a diphenylamino group or a C1-8 alkyl group, each of X and X? which are independent of each other, is an oxygen atom, a sulfur atom, a selenium atom, a propan-2,2-diyl group, a butane-2,2-diyl group, a C3-6 cycloalkane-1,1-diyl group, —NH— or —NY1—, each of Y, Y? and Y1 which are independent of one another, is a C1-3

Abstract: The present invention provides an optical recording medium that includes a recording layer composed mainly of an organic compound and can utilize blue-violet semiconductor laser light (390 to 420 nm in wavelength) as recording/reproducing laser light. The present invention also provides an optical recording/reproducing method using the optical recording medium. The optical recording medium 1 comprises at least a supporting substrate 2; a recording layer 3 on the supporting substrate 2, the recording layer 3 containing an organic compound as a major component; and a light-transmitting layer 5 on the recording layer 3, the light-transmitting layer 5 being capable of transmitting laser light with a wavelength of 390 to 420 nm for recording and reproducing information.

Abstract: Disclosed are novel compositions and methods employing cyclic nucleotide-gated channels and fluorescence dyes and other indicators in detecting changes of intracellular cAMP levels, for instance in response to the stimulation of G-protein-coupled receptors. CNG mutants comprising one or more pore mutations that enhance sensitivity to cAMP and decrease divalent cation-mediated blockage are used in a variety of assays, including detection of the G-protein-coupled receptor activity. Also disclosed are novel dye quencher formulations that are particularly suited for cell-based assays of protein interactions.

Abstract: A method for fabricating an optical recording medium is provided. A dye layer is formed on a molded substrate by spin-coating. A reflection layer is formed on the dye layer by sputtering so that the optical disc has enough reflection rate. The dye layer comprises a cyanine type dye and an azo metal chelate compound selected from the formula (I): wherein M is a metal ion; R1 is a hydrogen atom, a linear or branched alkyl group containing 1 to 6 carbon atoms, amino group, alkyl amino group or toluidinyl group; R2 is a hydrogen atom, a hydroxyl group, a halogen atom, an ether group, an ester group or a linear or branched alkyl group containing 1 to 6 carbon atoms; R3 is a hydrogen atom or a linear or branched alkyl group containing 1 to 6 carbon atoms; R4 is a hydrogen atom, a halogen atom or a linear or branched alkyl group containing 1 to 6 carbon atoms; A1 is a heterocyclic derivative group constituted by carbon atoms and nitrogen atoms.

Abstract: The invention discloses new benzoindole styryl compounds and its use for a high-density optical recording medium. The invention uses the dyes of the new benzoindole styryl compounds to form the recording layer of high-density recording media. The new benzoindole styryl compounds are easy to prepare and purify, so they are cheaper when comparing to the compounds generally used in high-density optical recording media. The benzoindole styryl compounds has a maximum absorption for the light wavelength in the range of 500 nanometers to 700 nanometers. The benzoindole styryl compounds also have high sensitivity and chemical stability for light and heat. Using the new benzoindole styryl compounds to form a high-density optical recording medium can match up with the short-wavelength laser beam for high-density optical recording media and have the advantage of a stable quality.

Abstract: The present invention provides an optical recording medium including a recording layer and an optical reflection layer formed on a substrate. The recording layer contains at least one particular polymethine pigment selected from polymethine pigments having 1 to 4 carbons in the methine main chain, so as to obtain a sufficient recording sensitivity for a red wavelength range of light.

Abstract: This invention provides a data storage media comprising at least a cyanine-TCNQ complex dye having the structural formula: wherein Q and Q′ denote aromatic or polyaromatic, R1 and R2 are selected from the group consisting of alkyl, arylester, alkoxy, alkylthio, and alkoxythio etc., n represents an integer of 0, 1, 2, and 3, TCNQ-m represents 7,7′,8,8′-tetracyanoquinodimethane or its derivatives, and m is an integer of 1 or 2. The data storage media comprising the cyanine-TCNQ complex dye includes a reflection optical recording media and a non-reflection fluorescent optical recording media suiting the requirement.

Abstract: The present invention provides an optical recording medium including a recording layer 2 and an optical reflection layer 3 formed on a substrate 1. The recording layer 2 contains at least one particular polymethine pigment selected from polymethine pigments having 1 to 4 carbons in the methine main chain, so as to obtain a sufficient recording sensitivity for a red wavelength range of light.

Abstract: The object of the present invention is to provide an optical recording medium which is excellent in the recording sensitivity and suitable for the high speed recording. Thus, the present invention is an optical recording medium comprising a substrate and a laser-writable and readable recording layer provided thereon, wherein said recording layer contains a chelate dye comprising two or more azo compounds having different structures and a divalent or more metal ion, and said azo compounds are a selected from azo compounds represented by the following general formula (I) and the general formula (II).

Abstract: A near-infrared absorbing filter, characterized in that it contains at least one compound represented by the following formula (1): 1

Abstract: An information recording medium showing a high light-resistance has a recording layer containing a dye compound having the following formula (I-1) or (I-2): 1

Abstract: Optical recording media using mixtures of benzoindolenic trimethine cyanine dyes, where the first benzoindolenic trimethine cyanine dye bears a heterocyclic azo dye metal complex as the counterion and the second benzoindolenic trimethine cyanine dye has a different type of counterion. This combination of these benzoindolenic trimethine cyanine dyes coated on a substrate results in high density media, where the dyes have a high solubility and heat resistance.

Abstract: Optical data carrier comprising a preferably transparent substrate which may, if desired, have previously been coated with one or more reflection layers and to whose surface a light-writeable information layer, if desired one or more reflection layers and if desired a protective layer or a further substrate or a covering layer have been applied, which can be written on and read by means of infrared light, preferably laser light, particularly preferably light having a wavelength in the range 750-800 nm, in particular 770-790 nm, where the information layer comprises a light-absorbent compound and, if desired, a binder, characterized in that at least one cobalt(III) phthalocyanine in which the Co metal centre bears two axial substituents R1 and R2 which represent, independently of one another, CN, SCN, alkoxy or alkylthio is used as light-absorbent compound.

Abstract: Optical recording media comprising a base (1), a recording layer (2) formed thereon, and a reflecting layer (3) formed on the layer (2), wherein the recording layer (2) contains at least one kind of specified dyes selected from among polymethine dyes having 1 to 4 carbon atoms in the main methine chain to secure a sufficient recording sensitivity to a light in the red wavelength region.

Abstract: The present invention relates to a singly recordable optical data medium using Co-phthalocyanine complexes of the formula (I) in which the groups are defined herein, as light-absorbing compounds in the information layer of optical data media, in which information layer is recordable using light, particularly for CD-R, and the application of the above-mentioned compounds to a polymer substrate, particularly polycarbonate, by spin coating.

Abstract: An optical information recording medium with a recording layer enables a recording and reproducing to be effected with a 650 nm (or further) laser beam, and the recording layer contains at least one kind of the trimethine-cyanine dye which is a compound represented by the following general formula [1], [2], [3], [4]. The “EWG” represents any electron-withdrawing substituted group such as cyano or nitro group.

Abstract: This invention provides a data storage media comprising at least a cyanine-TCNQ complex dye having the structural formula: 1

Abstract: An optical information recording medium including a substrate in which at least one of a groove and a pit is formed; a recording layer located overlying the substrate and including a dye; and a reflection layer located overlying the recording layer, wherein the optical information recording medium has an absorbance curve with an absorbance L of from 10 to 40% against light having a wavelength &lgr; of from 645 nm to 670 nm, a ratio (Lmax/Lmin) of a maximum absorbance Lmax of the absorbance curve to a minimum absorbance Lmin of from 1.0 to 2.0 at the wavelength range of from 645 nm to 670 nm, and a reflectance of from 45 to 85% against the light having a wavelength &lgr; of from 645 nm to 670 nm.

Abstract: An optical recording element having a transparent substrate and on the surface of said substrate, a recording layer, a light reflecting layer is disclosed. The recording layer comprises (i) a metallized azo ether dye having an azo group linking a substituted 3-hydroxypyridine nucleus to a phenyl nucleus wherein the phenyl nucleus has an ether substituent ortho to the azo group and said phenyl nucleus is free of strong electron withdrawing groups and (ii) a cyanine dye. The recording layer also has, when unrecorded a refractive index, at a selected wavelength from 400 to 660 nm, comprising a real part (n) greater than 1.8 and an imaginary part (k) less than 0.2.

Abstract: Optical data carrier comprising a preferably transparent substrate which may, if desired, have previously been coated with one or more reflection layers and to whose surface a light-writeable information layer, if desired one or more reflection layers and, if desired, a protective layer or a further substrate or a covering layer have been applied, which can be written on or read by means of blue or red light, preferably laser light, where the information layer comprises a light-absorbent compound and, if desired, a binder, characterized in that at least one xanthene dye which contains at least two anionic groups and has at least one cation containing at least one conjugated &pgr; system having at least 6 &pgr; electrons as counterion, where the cation must not be benzyltrimethylammonium, benzyltriethylammonium, tetraphenylphosphonium, butyltriphenylphosphonium or ethyltriphenylphosphonium, is used as light-absorbent compound.

Abstract: This invention is to provide a kind of cyanine-TCNQ complex dyes mixture (II, III, and IV) used as the data storage media having the structural formula (I): 1

Abstract: An optical recording medium has a substrate, and a recording layer formed thereon which contains at least one formazan chelate compound of formula (I), (II) or 1

Abstract: A complex of a dye cation and an anionic TCNQ derivative of the formula (I): in which [Dye]+ is a dye cation, L1 is a linking group, R1 is a substituent group, p is an integer of 1-4, and r is an integer of 0-3 under the condition of 1<p+r<4, is favorably employable as a dye compound for preparing a recording layer of CD-R or DVD-R.

Abstract: In a write once optical recording medium comprising a recording layer and a light transmitting protective layer formed successively on a supporting body, for recording and reproduction by irradiating a laser beam of a 380 to 450 nm wavelength from the light transmitting protective layer side, &lgr;max≦370 nm on the premise that the wavelength providing the peak optical absorption coefficient of the recording layer is defined to be &lgr;max.

Abstract: Metallized azo thioether dyes having an azo group linking a substituted 3-hydroxypyridine nucleus to a phenyl nucleus are disclosed. The phenyl nucleus has an thioether substituent ortho to the azo group but does not have electron withdrawing substituents on the phenyl nucleus. The dyes are useful in optical recording elements.

Abstract: There is disclosed an optical recording medium having at least a recording layer provided on a light-transmissive substrate having grooves and lands with prepits, wherein said lands are generally rectangular or trapezoidal in cross section having a top surface and sidewalls, as well as a specified land height (h1), and said prepits are formed in a land in the center area of the land in a width direction thereof, and spaced from the adjacent grooves by boundary walls of a specified height (h2). The optical recording medium permits address information and disc rotation control information to be accessed accurately even if a track pitch is small, and which still can be manufactured efficiently, with the added capability of signal recording in high density and reproduction of high-quality signals.

Abstract: An object of the invention is to provide a method for preparing an optical recording medium, featuring a high production yield, a reduced loss and a high utilization of dye solution, and ensuring to produce media of consistent quality even by continuous coating as well as an optical recording medium. The object is achieved by a method for preparing an optical recording medium, comprising the step of applying a solution of a dye in a solvent onto a resin substrate to form a dye film, wherein the solvent of the dye solution is a mixture of tetrafluoropropanol and/or octafluoropentanol with an aliphatic saturated alcohol of 1 to 4 carbon atoms, and a recording layer is formed by applying the dye solution.

Abstract: The object of the present invention is to provide an optical recording medium which is excellent in the recording sensitivity and suitable for the high speed recording.

Abstract: The present invention discloses optical recording elements having optical recording layers containing tetra dyes. The dyes have metallized azo dianionic dye with cationic dye counterions. The recording layer has a thickness from 225 to 300 nm.

Abstract: A complex of a dye cation and an anionic TCNQ derivative of the formula (I): 1

Abstract: An optical recording medium is provided that includes a spirally grooved polymer substrate, a recording layer, a reflecting layer, and a protection layer. The recording layer includes one or a mixture of phthalocyanine dyes. The phthalocyanine dye includes a bicyclo-alkyl substituent, providing solubility in any of a plurality of solvents that will not damage the surface of the substrate.

Abstract: An information recording medium is disclosed, comprising a substrate having provided thereon a recording layer capable of recording information by a laser ray, wherein the recording layer contains a dye compound represented by formula (I-1): 1

Abstract: Metallized azo ether dyes having an azo group linking a substituted 3-hydroxypyridine nucleus to a phenyl nucleus are disclosed. The phenyl nucleus has an ether substituent ortho to the azo group. The phenyl nucleus is free of strong electron withdrawing substituents. The dyes are useful in optical recording elements.

Abstract: An optical information recording medium is composed of a substrate, a recording dye layer on which information can be recorded by irradiation with a laser beam, and a light-reflecting layer overlaid in order, in which the recording dye layer employs a dye having an organic counter ion (such as a cyanine dye of the formula (I): [DYE+]nXn−  (I) in which DYE+ is a monovalent cyanine dye cation, n is an integer not less than 2, and Xn− is an organic n-valent anion), and the light-reflecting layer is made of Ag or Ag-containing alloy.