Involving Glucose Or Galactose Patents (Class 435/14)
  • Patent number: 11137387
    Abstract: A method of identifying or evaluating synergistic combinations of actives such as skin-care actives that improve the metabolism of a cell and provides an advantage over using the actives alone. The method includes contacting cells with test agents, alone and in combination, and determining a response of the cells to the test agent(s), wherein the response corresponds to a change in a metabolic indicator associated with glycolysis and a change in a metabolic indicator associated with oxidative phosphylation.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: October 5, 2021
    Assignee: The Procter & Gamble Company
    Inventors: John Erich Oblong, Holly Ann Rovito
  • Patent number: 11123011
    Abstract: Methods, systems, and devices are described herein for various embodiments of using a sample analysis system to analyze a sample of bodily fluid from a user to determine parameters associated with the user including states of hydration, dehydration, rehydration, electrolyte loss, wellness, recovery, and the like. In some embodiments, the methods disclosed can be implemented using a device worn by a user, and operatively coupled to a sample analysis system configured to collect a sample of bodily fluid, and measure and analyze the bodily fluid to determine a property of the bodily fluid and/or a physiological/wellness parameter (e.g., degree of hydration, electrolyte losses, perspiration rate, etc.) of the user.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: September 21, 2021
    Assignee: Nix, Inc.
    Inventors: Shawn Mishra, Kenneth Ritsher, Meridith Unger Cass
  • Patent number: 11104903
    Abstract: The invention relates to nucleic acids and methods for restoring acid alpha-glucosidase (GAA) activity in patients with Pompe disease using splice-switching technology.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: August 31, 2021
    Assignee: SYNTHENA AG
    Inventors: Luis Garcia, Aurelie Avril
  • Patent number: 11092604
    Abstract: The present invention provides a glucose sensor having a glucose receptor containing a binding site of formula (I): wherein X, n, m and R1 are defined herein. Also provided is a glucose sensor molecule for use in such a glucose sensor, the glucose sensor molecule containing the binding site of formula (I). The binding site has been found to have particularly good selectivity for glucose.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: August 17, 2021
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Nicholas Paul Barwell, Tony James
  • Patent number: 11078517
    Abstract: This invention provides an amadoriase that acts on the ?-chain of hemoglobin A1c (HbA1c) and generates hydrogen peroxide, a method for measurement of HbA1c using such amadoriase, and a reagent kit for measurement of HbA1c using such amadoriase. The method for measurement of HbA1c involves the use of an amadoriase that has specific activity of 0.1 U/mg or greater to ?F6P and oxidizes the HbA1c ?-chain amino terminus so as to generate hydrogen peroxide, and the reagent kit for measurement of HbA1c comprises such amadoriase. The method and the kit for measurement of HbA1c enable quantification of HbA1c to be performed rapidly, simply, and accurately.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: August 3, 2021
    Assignee: Kikkoman Corporation
    Inventors: Yosuke Masakari, Atsushi Ichiyanagi
  • Patent number: 11072809
    Abstract: An object of the present invention is to construct a more excellent glucose sensor, and to provide GDH more suitable for the glucose sensor. Provided is FAD-dependent glucose dehydrogenase in which the range of molecular weight distribution observed by SDS-PAGE is within 50 kDa when viewed in a molecular weight distribution in which the relative value of band intensity exceeds 60% of the maximum value.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: July 27, 2021
    Assignee: TOYOBO CO., LTD.
    Inventor: Yuu Utashima
  • Patent number: 11053556
    Abstract: This disclosure pertains to a testing method for a target pathogen. The method uses biosensors with particular fluorescence characteristics, such that when the biosensor binds to a target pathogen, a fluorophore may emit light if excited. The biosensor may be an aptamer-based biosensor with a fluorophore reporter and a quencher. The excitation of the fluorophore and the detection of fluorescence may be made through the use of a flashlight source and a camera from a mobile device, such as a smartphone.
    Type: Grant
    Filed: February 22, 2021
    Date of Patent: July 6, 2021
    Inventors: Najeeb Ashraf Khalid, Naqeeb Khalid
  • Patent number: 10973888
    Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH<4.5) and basic (pH>7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: April 13, 2021
    Assignee: Codexis, Inc.
    Inventors: Nicholas J. Agard, Mathew G. Miller, Xiyun Zhang, Gjalt W. Huisman
  • Patent number: 10956821
    Abstract: Embodiments for accurate temporal event predictive modeling by a processor. An average reverse event delay may be determined from one or more event delays in a time-series window. A time-series event may be predicted by applying the average reverse event delay in conjunction with one or more weighted factors in a predictive model.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: March 23, 2021
    Assignee: International Business Machines Corporation
    Inventors: Charu C. Aggarwal, Lingtao Cao, Tan Hung M. Ng, Saket Sathe, Deepak S. Turaga
  • Patent number: 10952664
    Abstract: A mobile apparatus is adapted to be handheld and configured for electronic processing of blood sugar affecting factors includes a first central processing unit arranged for processing of patient critical information objects, at least one memory comprising a plurality of in advance stored food units and values of at least one related blood sugar affecting parameter, an input unit arranged to provide user input such as a choice of food units and an amount thereof, a display arranged for visualization of food units for said user input, and for visualization of summed up blood sugar affecting parameters, and a second central processing unit arranged for processing of patient non-critical information objects.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: March 23, 2021
    Assignee: Cross Technology Solutions AB
    Inventors: Thomas Bergqwist, George Sioustis
  • Patent number: 10937536
    Abstract: The optimal insulin to be delivered by an insulin infusion pump is determined by using a reinforcement learning algorithm aiming to the personalized glucose regulation. The algorithm optimizes the daily basal insulin rate and insulin: carbohydrate ratio for each patient, on the basis of his/her measured glucose profile. The proposed algorithm is able to learn in real-time patient-specific characteristics captured in the daily glucose profile and provide individualized insulin treatment. An automatic and personalized tuning method contributes in the optimisation of the algorithm's performance.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: March 2, 2021
    Assignee: UNIVERSITĂ„T BERN
    Inventors: Stavroula Mougiakakou, Eleni Daskalaki, Peter Diem
  • Patent number: 10927404
    Abstract: This disclosure pertains to a testing method for a target pathogen. The method uses biosensors with particular fluorescence characteristics, such that when the biosensor binds to a target pathogen, a fluorophore may emit light if excited. The biosensor may be an aptamer-based biosensor with a fluorophore reporter and a quencher. The excitation of the fluorophore and the detection of fluorescence may be made through the use of a flashlight source and a camera from a mobile device, such as a smartphone.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: February 23, 2021
    Assignee: 4233999 CANADA INC.
    Inventors: Najeeb Ashraf Khalid, Naqeeb Khalid
  • Patent number: 10925536
    Abstract: A flexible system capable of utilizing data from different monitoring techniques and capable of providing assistance to patients with diabetes at several scalable levels, ranging from advice about long-term trends and prognosis to real-time automated closed-loop control (artificial pancreas). These scalable monitoring and treatment strategies are delivered by a unified system called the Diabetes Assistant (DiAs) platform. The system provides a foundation for implementation of various monitoring, advisory, and automated diabetes treatment algorithms or methods. The DiAs recommendations are tailored to the specifics of an individual patient, and to the patient risk assessment at any given moment. A central data exchange node or server collects patient data from individual DiAs devices and provides safety assurance, monitoring, telemedicine and database building for the DiAs system.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: February 23, 2021
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventor: Boris P. Kovatchev
  • Patent number: 10898115
    Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: January 26, 2021
    Assignee: DexCom, Inc.
    Inventors: Jason Halac, John Michael Gray, Neal Davis Johnston, Justen Deering England, Peter C. Simpson, Paul V. Neale, Jennifer Blackwell, Maria Noel Brown Wells, Kenneth Pirondini, Andrew Michael Reinhardt, Mark Douglas Kempkey
  • Patent number: 10883133
    Abstract: The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to FAD to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: January 5, 2021
    Assignees: Ikeda Food Research Co., Ltd., PHC Corporation
    Inventors: Hironori Omura, Hirokazu Sanada, Takako Yada, Ayaka Atsumi, Tetsunari Morita, Emi Ishimaru
  • Patent number: 10877051
    Abstract: The invention provides fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening superoxide. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. The invention further provides fluorogenic compounds for selectively staining superoxide in the mitochondria of living cells. The invention also provides methods that can be used to measure, directly or indirectly, the presence and/or amount of superoxide in chemical samples and biological samples such as cells and tissues in living organisms, and a high-throughput screening methods for detecting or screening superoxide or compounds that can increase or decrease the level of superoxide in chemical and biological samples.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: December 29, 2020
    Assignee: THE UNIVERSITY OF HONG KONG
    Inventors: Dan Yang, Nai-Kei Wong, Jun Hu
  • Patent number: 10871496
    Abstract: Disclosed is a platform detecting glycated hemoglobin as an indicator for diabetes in the blood based on upconverting nanoparticles excited by near-infrared light and luminescence resonance energy transfer.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: December 22, 2020
    Assignee: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Min-Gon Kim, Hyo-Young Mun, Eun-Jung Jo
  • Patent number: 10859571
    Abstract: A method and a system for quantitative or qualitative determination of a target component in a liquid sample includes i) providing a plurality of magnetic particles including one or more capture sites for the target component on their respective surfaces; ii) providing a plurality of fluorophores configured to bind to the capture sites of the magnetic particles; iii) bringing the liquid sample into contact with the fluorophores and the magnetic particles in a flow channel of a micro fluidic device including a transparent window; and iv) at least temporally immobilizing the magnetic particles adjacent to the transparent window using a magnet, emitting exciting electromagnetic beam towards the immobilized magnetic particles, reading signals emitted from fluorophores captured by the immobilized magnetic particles and performing a quantitative or qualitative determination of the target component based on the read signal.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: December 8, 2020
    Assignee: ZOETIS DENMARK ApS
    Inventors: Martin Bak Heller, Bent Overby, Niels Kristian Bau-Madsen
  • Patent number: 10823745
    Abstract: An object of the present invention is to provide a blood test kit and a blood analysis method capable of performing a blood test with a small amount of blood at high accuracy by visualizing a volume of blood collection and keeping the volume constant. According to the present invention, a blood test kit including a diluent solution for diluting components of a blood sample; and at least one transparent container for storing the components of the blood sample and the diluent solution, in which at least one constituent component included in the blood test kit is marked with a graduation for measuring the components of the blood sample and a liquid volume of the diluent solution, is provided.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: November 3, 2020
    Assignee: FUJIFILM Corporation
    Inventors: Seiji Yamashita, Haruyasu Nakatsugawa, Susumu Osawa, Shinya Sugimoto
  • Patent number: 10801066
    Abstract: A method for a determining of risk for development of cardiovascular disease by measuring levels of the at least gene of interest is disclosed. The method may identify subjects with moderate albuminuria and diagnosis or predict cardiovascular disease several years before either of these outcomes is detectable by present methodologies.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: October 13, 2020
    Assignee: American University of Beirut
    Inventors: Kamal F. Badr, Assaad A Eid, Robert H. Habib
  • Patent number: 10781469
    Abstract: The present disclosure provides, inter alia, mediator formulations for the measurement of an analyte comprising at least one ruthenium compound and at least one osmium compound. Also disclosed are reagent formulations for the measurement of an analyte comprising at least one ruthenium compound and at least one osmium compound. Also disclosed are methods and devices for the measurement of an analyte in a sample.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: September 22, 2020
    Assignee: Omni Biomedical, Inc.
    Inventors: David Zhi Deng, Gary T. Neel
  • Patent number: 10752934
    Abstract: The present invention provides a soluble pyrroloquinoline-quinone-dependent glucose dehydrogenase (PQQ-sGDH) mutant, wherein the amino acid positions thereof correspond to a wild-type PQQ-sGDH sequence of Acinetobacter calcoaceticus as shown in SEQ ID NO 1 comprising one of the following group of mutations: A194F, a combined mutation based on A194F, a combined mutation based on Q192A or a combined mutation based on Q192S. Said PQQ-sGDH mutant has good glucose substrate specificity and significantly reduced cross-reactivity to maltose and the like, and is suitable for detecting glucose in a sample such as blood.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: August 25, 2020
    Assignee: LEADWAY (HK) LIMITED
    Inventors: Zhe Wang, Xin Bi, Riyong Qiu
  • Patent number: 10739361
    Abstract: An object of the present invention is to provide a blood analysis method in which a high level of repeatability and reproducibility is achieved with respect to measurement values in a blood sample, and a blood test kit which is used for the blood analysis method.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: August 11, 2020
    Assignee: FUJIFILM Corporation
    Inventors: Tatsuya Ishizaka, Haruyasu Nakatsugawa, Susumu Osawa, Shinya Sugimoto
  • Patent number: 10702686
    Abstract: A wound oxygen supply system includes a chassis that defines an oxygen outlet. an oxygen production subsystem is included in the chassis and coupled to the oxygen outlet. A control subsystem is coupled to the oxygen production subsystem and configured to receive humidity information that is indicative of a humidity experienced by the oxygen production subsystem. The control system then uses the humidity information to control power provided to the oxygen production subsystem in order to control an oxygen flow that is created by the oxygen production subsystem and provided through the oxygen outlet to a restricted airflow enclosure adjacent a wound site.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: July 7, 2020
    Assignee: Electrochemical Oxygen Concepts, Inc.
    Inventors: Mark Q. Niederauer, James P. Daley, Joseph J. Moffett
  • Patent number: 10706524
    Abstract: Systems and methods for analyzing stained fabric articles are provided herein. In an embodiment, a method for analyzing stained fabric articles includes providing a stained fabric article that includes a foreign oily substance disposed in and/or on the fabric article. At least one image of the stained fabric article is captured using a three-dimensional imaging device, wherein the at least one image is captured in the absence of a colored dyes added to the foreign oily substance in and/or on the fabric article. The at least one image is processed using a contrast function to produce a processed data set. One or more of a processed image or a quantitative data set that is representative of oily substance presence in the viewing area of the three-dimensional imaging device is produced based upon the processed data set.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: July 7, 2020
    Assignee: Henkel IP & Holding GmbH
    Inventors: Paul Kichar, Maxime Pelletier, Michelle Avelina Piombino, Joseph David Dahlmeyer, Jr.
  • Patent number: 10704073
    Abstract: There is provided a method for easily determining an undifferentiated state of pluripotent stem cells without relying on the judgment of a skilled technician. The method includes: a step of evaluating an undifferentiated state of pluripotent stem cells based on a time-dependent change in a variation value of an extracellular metabolite contained in a culture medium in which the pluripotent stem cells are cultured, wherein the extracellular metabolite is at least one selected from a group consisting of L-glutamic acid, L-alanine and ammonia.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: July 7, 2020
    Assignee: TOKYO ELECTRON LIMITED
    Inventors: Kunitada Hatabayashi, Kentaro Tomita, Shinichi Gomi, Tomoaki Kurakazu, Yasuhiro Oshima, Kenichi Kagawa, Shigenori Ozaki
  • Patent number: 10697922
    Abstract: Disclosed is a biosensor with improved humidity resistance that can be used as a glucose sensor or a lactate sensor. The biosensor includes: an insulative substrate; an electrode system having a working electrode and a counter electrode provided on the substrate; and a reagent layer provided on the electrode system. The reagent layer contains an oxidoreductase and 1-methoxy-5-methylphenazinium ethyl sulfate. This biosensor can be used as a glucose sensor or a lactate sensor.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: June 30, 2020
    Assignee: ARKRAY, Inc.
    Inventor: Hisashi Kaneda
  • Patent number: 10633453
    Abstract: Disclosed herein is a hinge antibody capable of being selectively activated in a target cell or tissue to treat a condition therein. The hinge antibody includes a functional antibody, two inhibitory domains and four cleavable linkers. The functional antibody is capable of treating the condition in an activated state, and has two light chains and two heavy chains. Each inhibitory domain includes a hinge domain of an immunoglobulin and consists of two peptide arms. Each cleavable linker includes a peptide substrate cleavable by an enzyme specifically or highly expressed in the target cell or tissue, and connects one of the peptide arms of the inhibitory domains to the N-terminal of one of the light chains and heavy chains of the functional antibody. Also disclosed herein are methods for preparing and using this hinge antibody.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: April 28, 2020
    Assignees: KAOHSIUNG MEDICAL UNIVERSITY, DCB-USA LLC
    Inventors: Tian-Lu Cheng, Chih-Hung Chuang, Hsiu-Fen Ko, Yun-Chi Lu
  • Patent number: 10627361
    Abstract: An electrochemical test device for determining a concentration of an analyte in a fluid sample is provided. The electrochemical test device comprises a set of electrodes including a working electrode for the analyte and sensing chemistry for the working electrode, wherein the sensing chemistry comprises a diaphorase, an electron transfer agent having a standard redox potential in the range of ?0.52 to 0.18 V, an NAD(P)+-dependent dehydrogenase and a cofactor for the NAD(P)+-dependent dehydrogenase.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: April 21, 2020
    Assignee: INSIDE BIOMETRICS INTERNATIONAL LIMITED
    Inventors: Marco Cardosi, Stephanie Kirkwood
  • Patent number: 10548537
    Abstract: A testing system and method for providing a testing system includes a user interface having a display for displaying information relating to measurements of health data and an input device for receiving information from a user relating to the health data. Provided in connection with the user interface is an autologging feature adapted to provide the user with user-selectable options on the display. Also provided is a statistical operation adapted to provide the user with enhanced information relating to the measurements of health data. Also provided is at least one indicator for indicating information relating to the number of health data readings that are within a target range, the number of health data readings that are above the target range and the number of health data readings that are below the target range.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: February 4, 2020
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventors: Jacob Brauer, Darren Brown, Jun Chen, Richard Kates, Jennifer M. Levin, Harris Lieber, Amy Schwartz, Raymond Yao
  • Patent number: 10526418
    Abstract: Compositions of modulators of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1) expression, function or activity are provided. In particular, inhibitors of ALCAT1 are useful in treating metabolic diseases, cardiac diseases and, in general diseases associated with mitochondrial dysfunction. Assays for identification of novel ALCAT1 modulators are provided.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: January 7, 2020
    Assignee: The Penn State Research Foundation
    Inventor: Yuguang Shi
  • Patent number: 10510920
    Abstract: A silanized ITO electrode modified with ITO nanoparticles is described. ITO nanoparticles of cubic and semispherical shapes are immobilized on a silanized ITO film. The electrode may be used in an electrolytic cell to detect aqueous sulfide with a 0.5-1.4 ?M limit of detection. The electrode shows high specificity towards aqueous sulfide and a high reproducibility in measurement.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: December 17, 2019
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Md. Abdul Aziz, Zain Hassan Abdallah Yamani
  • Patent number: 10494658
    Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: December 3, 2019
    Assignee: BIOMERIEUX SA
    Inventors: Sylvain Orenga, CĂ©line Roger-Dalbert, John Perry, Vanessa Chanteperdrix, Gilles Zambardi, Nathalie Bal
  • Patent number: 10473664
    Abstract: The application provides heat-treated Limulus amebocyte lysates useful for detecting ?-glucans.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: November 12, 2019
    Assignee: Charles River Laboratories, Inc.
    Inventor: Masakazu Tsuchiya
  • Patent number: 10466247
    Abstract: A system and method are provided for utilizing radiometric fluorescence detection to determine a glucose independent concentration value when measuring frequency bands that do not contain the system isosbestic point. Preferably two bands are chosen such that a first band is below the system isosbestic point, and a second band is above the system isosbestic point, and both points are sufficiently far from the frequency endpoints to maximize the signal to noise ratio.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: November 5, 2019
    Assignee: Becton, Dickinson and Company
    Inventor: Steven Keith
  • Patent number: 10422737
    Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: September 24, 2019
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Utkan Demirci, Waseem Asghar
  • Patent number: 10391242
    Abstract: A method of managing use of an insulin infusion device is presented here. The method identifies bolus calculator event data from glucose data for a user of the infusion device. The bolus calculator event data corresponds to use of a bolus calculator that calculates bolus dosage recommendations based on a user entered carbohydrate consumption value, a user entered current blood glucose value, a user specific carbohydrate ratio value, and a user specific insulin sensitivity value. The method filters the bolus calculator event data to remove glucose data associated with certain conditions, and analyzes the filtered data to detect an event occurrence that is indicative of potential maladjustment of the carbohydrate ratio value or the insulin sensitivity value. The method outputs a recommendation to adjust the carbohydrate ratio value or the insulin sensitivity value, based on characteristics of the detected event occurrence.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: August 27, 2019
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Pratik Agrawal, Brian T. Kannard, Francine R. Kaufman
  • Patent number: 10386379
    Abstract: A chemical sensing system is described. The chemical sensing system can include a plurality of sensors arranged on at least one substrate. The sensors may have differing sensitivities to sense different analytes, and may each be configured to output a signal in response to sensing one or more of the different analytes. The chemical sensing system can further include a computer processor programmed to receive the signals output from the plurality of sensors. The computer processor may be further programmed to determine a concentration of analytes in the sample based, at least in part, on the received signals and a model relating the signals or information derived from the signals to an output representation having bases corresponding to analytes.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: August 20, 2019
    Assignee: Stratuscent Inc.
    Inventors: Mojtaba Khomami Abadi, Amir Bahador Gahroosi, Matthew V. Gould, Ashok Prabhu Masilamani
  • Patent number: 10373519
    Abstract: A method and apparatus for determining and providing activity recommendations includes receiving glucose level data and activity data. The glucose level data is formed into two or more data sets, with each set representing a different time period. Each data set is evaluated and ranked against each other set according to one or more of several different individual factors and the individual ranking for each set are combined, resulting in an overall ranking for given data sets. A highest ranked data set is then determined, which is associated thereby with a highest ranked time period. Activities of the activity data which took place within the highest ranked time period are provided as recommendations to the user to encourage greater numbers of times those activities are undertaken.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: August 6, 2019
    Assignee: Glooko Inc.
    Inventors: Reid Offringa, Michael S. Greenfield
  • Patent number: 10371698
    Abstract: Apparatus for performing an assay to detect the presence of an analyte in a test sample. A housing defines a slot for receiving a sample collector, and a capsule contains a buffer liquid, the capsule being sealed by an openable lid, and being connected to the housing such that insertion of a sample collector into the slot causes the lid to open releasing the buffer liquid into the slot. The housing further defines an incubation chamber containing or configured to receive a reagent, and an aperture permitting liquid communication between the slot and the incubation chamber. The apparatus comprises one or more test elements, a substantially liquid tight sealing member separating the incubation chamber and the test element(s), and an activation mechanism operable to open the liquid tight sealing member thereby bringing at least a portion of the or each test element into liquid communication with the incubation chamber.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: August 6, 2019
    Assignee: ALERE TOXICOLOGY PLC
    Inventors: Alan Pang, Gordon Jowett, Barry Lillis, Jack Fairbank
  • Patent number: 10324094
    Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: June 18, 2019
    Assignee: Yale University
    Inventors: Irina Buhimschi, Catalin S. Buhimschi, Michael Choma, Hemant Tagare, Stephan Michael Jonas
  • Patent number: 10307437
    Abstract: This invention is about the compositions and methods for assessing and treating vascular endothelial dysfunction. Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject. In one embodiment the dose is administered to subjects in response to the indicator. In another embodiment the dose is administered chronically to subjects.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: June 4, 2019
    Assignee: The Regents of the University of Colorado, a Body Corporate
    Inventors: Douglas R. Seals, Lindsey Gano, Natalie Poliektor
  • Patent number: 10240184
    Abstract: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: March 26, 2019
    Assignee: Promega Corporation
    Inventors: Keith V. Wood, Georgyi V. Los, Robert F. Bulleit, Dieter Klaubert, Mark McDougall, Chad Zimprich
  • Patent number: 10214552
    Abstract: A method for purifying ?-nicotinamide mononucleotide (NMN) includes: sequentially microfiltrating and nanofiltrating a crude product solution containing NMN using membrane concentration devices to obtain a concentrated crude product solution; adjusting the concentrated crude product solution to pH 3-7 to obtain a loading solution, loading the loading solution onto a preparative reverse phase high performance liquid chromatographic column, and purifying by gradient elution using an octadecylsilane-bonded silica gel as a stationary phase, a hydrochloric acid solution at pH 3-7 as a mobile phase A, and 100% ethanol as a mobile phase B, to obtain a purified sample solution; concentrating the purified sample solution by nanofiltration and freeze drying in a vacuum freeze drier to obtain a purified NMN.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: February 26, 2019
    Assignee: BONTAC BIO-ENGINEERING (SHENZHEN) CO., LTD.
    Inventors: Rongzhao Fu, Zhu Dai, Qi Zhang
  • Patent number: 10214556
    Abstract: A method for purifying a salt of reduced form of ?-nicotinamide adenine dinucleotide (NADH) includes: sequentially microfiltrating and nanofiltrating a reaction solution obtained after an enzymatic reaction, collecting a concentrate for use; adding an ion pair reagent to the concentrate, and purifying by gradient elution to obtain a purified filtrate using a reverse-phase chromatographic column as a stationary phase, a buffer solution as a phase A, and ethanol as a phase B; changing the cations in the purified filtrate into sodium ions to obtain a filtrate by using a cation exchange resin; and nanofiltrating the filtrate, and freeze drying in a vacuum freeze drier. The method results in an excellent purity and yield of a salt of NADH that meets requirements in industry.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: February 26, 2019
    Assignee: BONTAC BIO-ENGINEERING (SHENZHEN) CO., LTD
    Inventors: Rongzhao Fu, Zhu Dai, Qi Zhang
  • Patent number: 10168371
    Abstract: A system for determining the impact of moisture on a dielectric sealing material may include a testing apparatus having a testing chamber. A dielectric sealing material and a conducting pin may be exposed to the testing chamber. A first electrical lead may be coupled to the conducting pin, and a second electrical lead may be coupled to the dialectic material. An insulation resistance measurement unit may be coupled to both the first electrical lead and the second electrical lead, and the insulation resistance measurement unit may be configured to measure an insulation resistance value between the electrical leads. The insulation resistance measurement unit may measure a first insulation resistance value of the dielectric sealing material in a first environmental condition, and the insulation resistance measurement unit may measure a second insulation resistance value of the dielectric sealing material at a second environmental condition, that is different than the first environmental condition.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: January 1, 2019
    Assignee: PA&E, HERMETIC SOLUTIONS GROUP, LLC
    Inventors: Hua Xia, Tucker Havekost, Daniel Brown, Erich Preissler, Mike Grimm
  • Patent number: 10130454
    Abstract: This document provides vaccine delivery devices and methods for vaccinating an animal (e.g., a mammal). For example, vaccine delivery devices that include a container having one or more openings, a vaccine depot located within the container, and a diffusion barrier located within the container in a manner such that material (e.g., an antigenic vaccine component) within the vaccine depot must pass through the diffusion barrier before reaching one of the openings are provided.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: November 20, 2018
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Douglas E. Jones, Matthew Brewer, Balaji Narasimhan, John Jackman
  • Patent number: 10077432
    Abstract: A flavin-conjugated glucose dehydrogenase which is composed of proteins having the following amino acid sequence (a), (b) or (c), and having glucose dehydrogenase activity: (a) an amino acid sequence represented by SEQ ID NO: 2, 3, 5, 6, 8 or 9; (b) an amino acid sequence in which one or more amino acids are deleted from, replaced in or added to the amino acid sequence represented by SEQ ID NO: 2, 3, 5, 6, 8 or 9; (c) an amino acid sequence having at least 85% identity with the amino acid sequence represented by SEQ ID NO 2 or 3, at least 95% identity with the amino acid sequence represented by SEQ ID NO 5 or 6, or at least 80% identity with the amino acid sequence represented by SEQ ID NO 8 or 9.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: September 18, 2018
    Assignee: IKEDA FOOD RESEARCH CO., LTD.
    Inventors: Takafumi Takumi, Mizuki Shigeshiro, Daisuke Sato
  • Patent number: 10036708
    Abstract: Methods, reagents, kits and systems are disclosed for determining an analyte in a sample suspected of containing the analyte where all reagents are soluble in aqueous solution. One assay method includes treating a sample suspected of containing the analyte under conditions such that if the analyte is present, an activator is brought into reactive configuration with a chemiluminescent compound to activates it. The sample is also treated with an agent to reduce signal not related to analyte. Finally, the sample is treated with a trigger solution thereby producing light from the activated chemiluminescent compound. No reagents are associated with a surface or other solid phase.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: July 31, 2018
    Assignee: Beckman Coulter, Inc.
    Inventors: Hashem Akhavan-Tafti, Dean G. Binger, Ying Chen, Renuka De Silva, Terri McLernon, James Mendoza, Bruce H. Odegaard, Michael Salvati, Nir Shapir, Wenhua Xie
  • Patent number: 10028691
    Abstract: A needle assembly. The needle assembly enabling the analysis of fluid trapped in a flashback chamber after an insertion needle has been inserted into a patient's vein.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: July 24, 2018
    Assignee: Smiths Medical ASD, Inc.
    Inventors: David Goral, Harsh Chheda, Jay Breindel, Gursel Akcay, James Muskatello, David Justmann