Involving Glucose Or Galactose Patents (Class 435/14)
  • Patent number: 11952320
    Abstract: An aqueous solution (20) containing carbohydrate for generating smoke consists of 91.9-98.95 wt % of pure water, 1-8 wt % of carbohydrate, and 0.05-0.1 wt % of a water soluble aromatic substance of orange flavor. A method for generating smoke includes preparing an aqueous solution (20) including 91.9-98.95 wt % of pure water, 1-8 wt % of carbohydrate, and 0.05-0.1 wt % of a water soluble aromatic substance of orange flavor; and vibrating the aqueous solution (20) at a high frequency, causing gradual atomization from a surface of the aqueous solution (20) to form droplets containing the carbohydrate and having a diameter in a range of 6-20 ?m.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: April 9, 2024
    Assignee: NOVACORP INC.
    Inventor: Ming-Cheng Chang
  • Patent number: 11918355
    Abstract: Apparatus, methods, and systems for detecting alcohol concentrations of an individual, and in particular in vivo alcohol concentrations of an individual. Alcohol sensing compositions include at least one alcohol-responsive active area comprising a concerted enzyme system having at least a first enzyme and second enzyme capable of acting in concert to facilitate the detection of alcohol. At least one of the enzymes in the concerted enzyme system is a ketoreductase.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: March 5, 2024
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Tianmei Ouyang, Ahmed Hisham Wali
  • Patent number: 11883126
    Abstract: Systems and methods are provided to calibrate an analyte concentration sensor within a biological system, generally using only a signal from the analyte concentration sensor. For example, at a steady state, the analyte concentration value within the biological system is known, and the same may provide a source for calibration. Similar techniques may be employed with slow-moving averages. Variations are disclosed.
    Type: Grant
    Filed: October 26, 2022
    Date of Patent: January 30, 2024
    Assignee: Dexcom, Inc.
    Inventors: Arturo Garcia, Peter C Simpson, Apurv U Kamath, Naresh C. Bhavaraju, Stephen J. Vanslyke
  • Patent number: 11839601
    Abstract: A cannabis-enriched enzymatically treated therapeutic composition. A therapeutic composition is described including water, glucose, glucose reaction product other than sucrose and fructose; a selected amount of a cannabinoid, a cannabinoid reaction product; optionally a terpene and optionally a terpene reaction product. Methods of making and using the compositions are also described.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: December 12, 2023
    Assignee: CANNA-B CURE LTD
    Inventor: Aharon M. Eyal
  • Patent number: 11842817
    Abstract: A method, system and computer readable medium for tracking changes in average glycemia in diabetes is based on a conceptually new approach to the retrieval of SMBG data. Using the understanding of HbA1c fluctuation as the measurable effect of the action of an underlying dynamical system, SMBG provides occasional glimpses at the state of this system and, using these measurements, the hidden underlying system trajectory can be reconstructed for individual diabetes patients. Using compartmental modeling a new two-step algorithm is provided that includes: (i) real-time estimate of HbA1c from fasting glucose readings, updated with any new incoming fasting SMBG data point(s), and (ii) initialization and calibration of the estimated HbA1c trace with daily SMBG profiles obtained periodically. The estimation of these profiles includes a factorial model capturing daily BG variability within two latent factors.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: December 12, 2023
    Assignee: University of Virginia Patent Foundation
    Inventors: Boris P. Kovatchev, Marc D. Breton
  • Patent number: 11821022
    Abstract: An analyte biosensor is provided having an analyte biosensing layer and an ethylene oxide absorption layer. The ethylene oxide absorption layer is provided over the analyte biosensing layer. A method is also provided.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: November 21, 2023
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Robert McKinlay, Chi-En Lin, Tri T. Dang
  • Patent number: 11793471
    Abstract: A method and system for monitoring the effectiveness of a patient's diabetes treatment plan by predicting, on a frequent basis, the patient's glycated hemoglobin (A1c) based on the patient's blood glucose (BG) may include applying a plurality of A1c models to a BG data set of the patient so as to obtain a plurality of calculated A1c values and identifying a best fit model amongst the plurality of A1c models by evaluating the plurality of calculated A1c values against at least one measured A1c value; calculating a predicted A1c value by applying the identified best fit model to the BG data set. Some embodiments may further include evaluating the predicted A1c value against a set of escalation rules to determine whether an escalation alert is required; alerting the patient's healthcare provider when it is determined the escalation alert is required; and outputting the predicted A1c value to the patient.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: October 24, 2023
    Inventor: Sidney Soong-Ling Chan
  • Patent number: 11783563
    Abstract: A method to assess a subject diagnosis is provided. The method includes receiving an image from an image-capturing device, the image comprising an area of interest in a test cartridge, and finding a border of the area of interest of the test cartridge and applying a geometrical transformation on an area delimited by the border of the test cartridge to bring the image of the area of interest in the test cartridge to a selected size and a selected shape. The method also includes identifying a target region within the area of interest of the test cartridge, evaluating a quality of the image based on a characteristic feature of the target region, and providing commands to adjust an optical coupling in the image-capturing device when the quality of the image is lower than a selected threshold.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: October 10, 2023
    Assignee: Quidel Corporation
    Inventors: Houman Yaghoubi, Curtis Marsh, Scott Rongey, Ziad Salem, Adonis Stassinopoulos
  • Patent number: 11740247
    Abstract: This document relates to methods and materials for assessing and/or treating obese mammals (e.g., obese humans). For example, methods and materials for using one or more interventions (e.g., one or more pharmacological interventions) to treat obesity and/or obesity-related comorbidities in a mammal (e.g., a human) identified as being likely to respond to a particular intervention (e.g., a pharmacological intervention) are provided.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: August 29, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Andres J. Acosta, Michael L. Camilleri
  • Patent number: 11726077
    Abstract: A method is provided for calibrating impedance-spectroscopic biomass sensors that are embodied to detect information regarding the quantity and/or size of living cells in a biomass by means of an electric field having a periodically changing field direction A calibration suspension encompasses an electrically conductive viscously flowable or viscoelastic carrier substance and electrically conductive solid particles and/or solid semiconductor particles received therein. An electric field is generated having a periodically changing field direction, which acts on the calibration suspension. At least one permittivity value is detected, respectively representing a permittivity of the calibration suspension, in a context of at least two electric fields having different field direction change frequencies. A difference value is ascertained that represents a difference between the detected permittivity values. The difference value is compared with a reference value associated with the calibration suspension.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: August 15, 2023
    Assignee: HAMILTON BONADUZ AG
    Inventors: Marlene Frank, Philipp Arquint, Theo Gaupp
  • Patent number: 11666216
    Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: June 6, 2023
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Axel Scherer, Peter A Petillo, Samson Chen, Azita Emami
  • Patent number: 11635334
    Abstract: Embodiments described herein are directed to a temperature measurement device that includes a sensor body configured to be placed on a skin of a user. The temperature measurement device can include a first section defining a first lower surface and having a first thickness, a second section defining a second lower surface and having a second thickness, and a channel separating the first lower surface from the second lower surface. The temperature measurement device can also include a first set of temperature sensors positioned across the first thickness, a second set of temperature sensors positioned across the second thickness, and a processor configured to estimate a tissue temperature of the user based on comparing temperature signals from the first set of temperature sensors with temperature signals from the second set of temperature sensors.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: April 25, 2023
    Assignee: Apple Inc.
    Inventors: Helia Rahmani, Anthony D. Minervini, Wanfeng Huang, James C. Clements, Jiandong Yu, Zijing Zeng, Charley T. Ogata
  • Patent number: 11629368
    Abstract: The present application discloses a planar enzyme sensor for measuring the concentration of an analyte in a solution comprising a substrate of an electrically insulating material supporting an electrode layer of an electrically conductive material. The substrate and electrode layer have a plurality of layers disposed thereon which include an enzyme layer and a microporous outer layer covering the enzyme layer, wherein the outer layer comprises a continuous phase of a water-resistant polymer (e.g. a polyvinylacetate or an acrylate copolymer), a protein (e.g. an enzyme) embedded in the continuous phase, and possibly polytetrafluoroethylene particles. The enzyme and the polytetrafluoroethylene particles provide a controlled porosity to the outer membrane.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: April 18, 2023
    Assignee: RADIOMETER MEDICAL APS
    Inventors: Thomas Kjaer, Thomas Steen Hansen, Lydia Dahl Clausen
  • Patent number: 11590243
    Abstract: The present invention relates to the formulation of adenoviral vectors in sorbitol containing compositions in combination with a further amorphous sugar, its formulation as well as a method for obtaining a dried composition.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: February 28, 2023
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Erwan Bourles, Olivier Despas, Delphine Guillaume, Frederic Mathot, Mathieu Vasselle
  • Patent number: 11567062
    Abstract: A computer-implemented method for providing a real-time estimate of glycosylated hemoglobin (HbA1c) of a patient from a self-monitoring blood glucose (SMBG) measurement, and tracking changes in average glycemia of said patient over time is disclosed.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: January 31, 2023
    Assignee: University of Virginia Patent Foundation
    Inventors: Boris P. Kovatchev, Marc D. Breton
  • Patent number: 11567012
    Abstract: A mold sensor is configured with an enclosed chamber in which a nutrient-treated substrate is positioned. The mold sensor includes a sensing system that is configured to measure a property of the substrate that corresponds to a pH value of the substrate. A controller operates the sensing system and is programmed to detect a presence of mold growing in the chamber by estimating the pH value from the measured property.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: January 31, 2023
    Assignee: Robert Bosch GmbH
    Inventors: Seow Yuen Yee, Franz Laermer, Thomas Rocznik, Ning Wang
  • Patent number: 11531025
    Abstract: Provided herein are methods and materials that allow targeting and imaging of interactions between probes and targets. In some embodiments, the probes include nanoscale materials with embedded solutions that can be used to measure physical enhancement by materials under X-ray irradiation. In some embodiments, the methods of the present invention include delivering a probe material to a target that can have a delivered donor material. In some embodiments, methods of the present invention include irradiating the target and determining an optical change in the probe characteristic of a physical enhancement.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: December 20, 2022
    Assignee: The Regents of the University of California
    Inventor: Ting Guo
  • Patent number: 11517231
    Abstract: A blood glucose test strip includes a base substrate, a calibration site, a test site and a non-volatile memory. The calibration site is disposed on the base substrate. A chemical reagent is applied on the calibration site. The test site is disposed on the base substrate. A chemical reagent is applied on the test site. The non-volatile memory is disposed on the base substrate. A calibration parameter is stored in the non-volatile memory. During a calibrating procedure, the calibration solution is dropped on the calibration site, a calibration parameter is calculated according to a first reaction result of the calibration solution and the chemical reagent, and the calibration parameter is stored in the non-volatile memory.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: December 6, 2022
    Assignee: EMEMORY TECHNOLOGY INC.
    Inventor: Hsin-Chou Liu
  • Patent number: 11484258
    Abstract: A method for obtaining an index for non-invasively identifying NASH is provided. A NASH determination method comprising a method for acquiring free radical consumption speed information by non-invasively detecting a redox reaction in a liver of a test animal in real time, comprises a step (1) of obtaining free radical concentration data by applying a magnetic resonance method to the liver as a measurement target after administering a probe into a body; a step (2) of obtaining imaging information by processing the obtained free radical concentration data; and a step (3) of obtaining a free radical consumption speed by kinetically measuring the imaging information over time, and comprises a step of determining whether or not the test animal has NASH, based on the free radical consumption speed information obtained through application to the test animal.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: November 1, 2022
    Assignee: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Masaharu Murata, Fuminori Hyodo, Makoto Hashizume, Ryosuke Nakata, Tomohiko Akahoshi
  • Patent number: 11455724
    Abstract: Systems and methods are disclosed for adjusting attributes of whole slide images, including stains therein. A portion of a whole slide image comprised of a plurality of pixels in a first color space and including one or more stains may be received as input. Based on an identified stain type of the stain(s), a machine-learned transformation associated with the stain type may be retrieved and applied to convert an identified subset of the pixels from the first to a second color space specific to the identified stain type. One or more attributes of the stain(s) may be adjusted in the second color space to generate a stain-adjusted subset of pixels, which are then converted back to the first color space using an inverse of the machine-learned transformation. A stain-adjusted portion of the whole slide image including at least the stain-adjusted subset of pixels may be provided as output.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: September 27, 2022
    Assignee: PAIGE.AI, Inc.
    Inventors: Navid Alemi, Christopher Kanan, Leo Grady
  • Patent number: 11442035
    Abstract: A method of depositing reagent on an electrochemical test sensor adapted to determine information relating to an analyte includes providing a base and forming an electrode pattern on the base. The method further includes depositing the reagent on at least the electrode pattern using a reagent-dispensing system. The reagent-dispensing system applies mechanical force to the reagent in the reagent-dispensing system to assist in providing a wet reagent droplet on at least the electrode pattern.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: September 13, 2022
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Boru Zhu, Herbert Henley, Jr.
  • Patent number: 11433088
    Abstract: Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: September 6, 2022
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Douglas R. Seals, Lindsey Gano, Natalie Poliektor
  • Patent number: 11412962
    Abstract: Systems, methods, and devices of a health device network may include: a non-invasive glucometer that non-invasively measures analyte levels; an invasive glucometer communicatively coupled directly to the non-invasive glucometer; a cloud-based server communicatively coupled to the non-invasive glucometer or the invasive glucometer; a user device communicatively coupled to the cloud-based server; and/or a user interface that displays the invasive glucose measurement, the non-invasive glucose measurement, a data batch, and/or processed data to the user. The non-invasive glucometer and/or the invasive glucometer may aggregate an invasive glucose measurement and a non-invasive glucose measurement into the data batch.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: August 16, 2022
    Inventors: David Miller, Devin Miller, Michael Jones, David Derrick
  • Patent number: 11408778
    Abstract: An electronic device housing encloses a temperature sensing system including a temperature sensor and a differential temperature probe. The differential temperature probe includes a flexible substrate defining two ends. A first end is thermally coupled to the temperature sensor and a second end is thermally coupled to a surface, volume, or component of the electronic device. The temperature probe is an in-plane thermopile including a series-coupled set of thermocouples extending from the first end to the second end. A temperature measured at the temperature sensor can be a first measured temperature and a voltage difference across leads of the differential temperature probe can be correlated to a differential temperature relative to the first measured temperature. A sum of the differential temperature and the first measured temperature is a second measured temperature, quantifying a temperature of the second end of the differential temperature probe.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: August 9, 2022
    Assignee: Apple Inc.
    Inventors: James C. Clements, Chad A. Bossetti, Habib S. Karaki, Paul Mansky
  • Patent number: 11402384
    Abstract: The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Grant
    Filed: November 19, 2016
    Date of Patent: August 2, 2022
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Malin J. Allert
  • Patent number: 11399745
    Abstract: Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: August 2, 2022
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, Mark Brister, Matthew Wightlin, Jack Pryor
  • Patent number: 11389765
    Abstract: The present disclosure relates to a transport mechanism apparatus for transporting at least one of a gas or a fluid. The transport mechanism may have an inlet, an outlet and a triply periodic minimal surface (TPMS) structure. The TPMS structure is formed in a layer-by-layer three dimensional (3D) printing operation to include cells propagating in three dimensions, where the cells include wall portions having openings, and where the cells form a plurality of flow paths throughout the transport mechanism from the inlet to the outlet, and where the cells form the inlet and the outlet.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: July 19, 2022
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Pratanu Roy, Du Nguyen, Joshuah K. Stolaroff
  • Patent number: 11389117
    Abstract: An apparatus for predicting hypoglycemia according to an exemplary embodiment of the present disclosure is an apparatus for predicting hypoglycemia, which predicts the occurrence of postprandial hypoglycemia using blood glucose-related information, wherein the blood glucose-related information includes a blood glucose level at a reference time, a blood glucose change rate over a duration from a mealtime to a postprandial peak blood glucose level time, a blood glucose change rate over a duration from the postprandial peak blood glucose level time to the reference time, and a blood glucose change rate at the reference time.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: July 19, 2022
    Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Sung Min Park, Won Ju Seo, Seung Hyun Lee
  • Patent number: 11391723
    Abstract: The present disclosure provides methods of processing data provided by a transcutaneous or subcutaneous analyte sensor utilizing different algorithms to strike a balance between signal responsiveness accompanied by signal noise and the introduction of error associated with that noise. The methods utilize the strengths of a lag correction algorithm and a smoothing algorithm to optimize the quality and value of the resulting data (glucose concentrations and the rates of change in glucose concentrations) to a continuous glucose monitoring system. Also provided are systems and kits.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: July 19, 2022
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Wesley Scott Harper, Erwin Satrya Budiman, Kenneth J. Doniger, Gary Alan Hayter
  • Patent number: 11378574
    Abstract: The present invention relates to a method for detecting a target substance that is useful for detection of a glycoprotein and the like comprising a specific sugar chain, a reagent for detecting a target substance, a carrier and a method for manufacturing the carrier.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: July 5, 2022
    Assignee: SYSMEX CORPORATION
    Inventors: Chikayuki Tsuruno, Shinya Nagai, Minako Terao, Chika Mizuta, Takuya Kyoutou
  • Patent number: 11375930
    Abstract: An electronic device for obtaining biometric information is provided. The electronic device includes at least one communication circuit, a first pad including a first electrode and a second electrode, the first electrode being coated with a catalyst associated with first biometric information, a second pad including at least a third electrode, and a processor for controlling the at least one communication circuit, the first pad, and the second pad. The processor is configured to obtain the first biometric information, based at least on an electric current generated by applying a specified voltage between the first electrode and the second electrode and obtain second biometric information, based at least on a voltage difference between the second electrode and the third electrode.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: July 5, 2022
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Injo Jeong, Hyunguk Yoo, Kunkook Park, Seungeun Lee
  • Patent number: 11278600
    Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH<4.5) and basic (pH>7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: March 22, 2022
    Assignee: Codexis, Inc.
    Inventors: Nicholas J. Agard, Mathew G. Miller, Xiyun Zhang, Gjalt W. Huisman
  • Patent number: 11215578
    Abstract: In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base, a first electrode and a second electrode wherein a thermocouple portion is provided integral with the second electrode thereby enabling on-sensor temperature measurement capability. In some embodiments, two and only two electrical contact engagement portions are provided thereby simplifying electrical contact. Manufacturing methods and systems utilizing the analyte sensors are provided, as are numerous other aspects.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: January 4, 2022
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Hoi-Cheong Steve Sun, John P. Creaven, Mu Wu, Paul M. Ripley, Steven C. Charlton
  • Patent number: 11197635
    Abstract: A healthcare apparatus according to an embodiment includes: a plurality of light sources configured to emit light of different wavelengths onto an object; a light detector configured to measure an optical signal of each of the wavelengths by receiving light reflected or scattered from the object; and a processor configured to obtain a blood glucose level and a blood flow index by using the optical signal of each of the wavelengths, and to estimate at least one from among dietary information and dietary metabolism state information by monitoring a blood glucose level change and a blood flow index change after ingestion of a food.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: December 14, 2021
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Ka Ram Choi, Hyo Sun Hwang, Jin Young Park, Jae Wook Shim, So Young Lee, Sang Kon Bae, Eui Seok Shin
  • Patent number: 11147486
    Abstract: A one step all-in-one apparatus for body fluid sampling and sensing, comprising: a housing(1), a plurality of integrated sampling and sensing assemblies, a cartridge(12), sealing films(101,102), an upper cover(13), a sampling port(6), a linear actuating mechanism and a control circuit, with every integrated sampling and sensing assembly comprising a micro fluid-sampling needle(2), a needle hub(3) and a test strip(4); the micro fluid-sampling needles(2) penetrate the skin to sample the body fluid and deliver the body fluid to the test strips(4) directly, and changes occurred on the test strips(4) are read by the sensor(5), wherein sampling and sensing are completed in one step.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: October 19, 2021
    Assignee: MEDTRUM TECHNOLOGIES INC.
    Inventor: Cuijun Yang
  • Patent number: 11137387
    Abstract: A method of identifying or evaluating synergistic combinations of actives such as skin-care actives that improve the metabolism of a cell and provides an advantage over using the actives alone. The method includes contacting cells with test agents, alone and in combination, and determining a response of the cells to the test agent(s), wherein the response corresponds to a change in a metabolic indicator associated with glycolysis and a change in a metabolic indicator associated with oxidative phosphylation.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: October 5, 2021
    Assignee: The Procter & Gamble Company
    Inventors: John Erich Oblong, Holly Ann Rovito
  • Patent number: 11123011
    Abstract: Methods, systems, and devices are described herein for various embodiments of using a sample analysis system to analyze a sample of bodily fluid from a user to determine parameters associated with the user including states of hydration, dehydration, rehydration, electrolyte loss, wellness, recovery, and the like. In some embodiments, the methods disclosed can be implemented using a device worn by a user, and operatively coupled to a sample analysis system configured to collect a sample of bodily fluid, and measure and analyze the bodily fluid to determine a property of the bodily fluid and/or a physiological/wellness parameter (e.g., degree of hydration, electrolyte losses, perspiration rate, etc.) of the user.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: September 21, 2021
    Assignee: Nix, Inc.
    Inventors: Shawn Mishra, Kenneth Ritsher, Meridith Unger Cass
  • Patent number: 11104903
    Abstract: The invention relates to nucleic acids and methods for restoring acid alpha-glucosidase (GAA) activity in patients with Pompe disease using splice-switching technology.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: August 31, 2021
    Assignee: SYNTHENA AG
    Inventors: Luis Garcia, Aurelie Avril
  • Patent number: 11092604
    Abstract: The present invention provides a glucose sensor having a glucose receptor containing a binding site of formula (I): wherein X, n, m and R1 are defined herein. Also provided is a glucose sensor molecule for use in such a glucose sensor, the glucose sensor molecule containing the binding site of formula (I). The binding site has been found to have particularly good selectivity for glucose.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: August 17, 2021
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Nicholas Paul Barwell, Tony James
  • Patent number: 11078517
    Abstract: This invention provides an amadoriase that acts on the ?-chain of hemoglobin A1c (HbA1c) and generates hydrogen peroxide, a method for measurement of HbA1c using such amadoriase, and a reagent kit for measurement of HbA1c using such amadoriase. The method for measurement of HbA1c involves the use of an amadoriase that has specific activity of 0.1 U/mg or greater to ?F6P and oxidizes the HbA1c ?-chain amino terminus so as to generate hydrogen peroxide, and the reagent kit for measurement of HbA1c comprises such amadoriase. The method and the kit for measurement of HbA1c enable quantification of HbA1c to be performed rapidly, simply, and accurately.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: August 3, 2021
    Assignee: Kikkoman Corporation
    Inventors: Yosuke Masakari, Atsushi Ichiyanagi
  • Patent number: 11072809
    Abstract: An object of the present invention is to construct a more excellent glucose sensor, and to provide GDH more suitable for the glucose sensor. Provided is FAD-dependent glucose dehydrogenase in which the range of molecular weight distribution observed by SDS-PAGE is within 50 kDa when viewed in a molecular weight distribution in which the relative value of band intensity exceeds 60% of the maximum value.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: July 27, 2021
    Assignee: TOYOBO CO., LTD.
    Inventor: Yuu Utashima
  • Patent number: 11053556
    Abstract: This disclosure pertains to a testing method for a target pathogen. The method uses biosensors with particular fluorescence characteristics, such that when the biosensor binds to a target pathogen, a fluorophore may emit light if excited. The biosensor may be an aptamer-based biosensor with a fluorophore reporter and a quencher. The excitation of the fluorophore and the detection of fluorescence may be made through the use of a flashlight source and a camera from a mobile device, such as a smartphone.
    Type: Grant
    Filed: February 22, 2021
    Date of Patent: July 6, 2021
    Inventors: Najeeb Ashraf Khalid, Naqeeb Khalid
  • Patent number: 10973888
    Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH<4.5) and basic (pH>7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: April 13, 2021
    Assignee: Codexis, Inc.
    Inventors: Nicholas J. Agard, Mathew G. Miller, Xiyun Zhang, Gjalt W. Huisman
  • Patent number: 10956821
    Abstract: Embodiments for accurate temporal event predictive modeling by a processor. An average reverse event delay may be determined from one or more event delays in a time-series window. A time-series event may be predicted by applying the average reverse event delay in conjunction with one or more weighted factors in a predictive model.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: March 23, 2021
    Assignee: International Business Machines Corporation
    Inventors: Charu C. Aggarwal, Lingtao Cao, Tan Hung M. Ng, Saket Sathe, Deepak S. Turaga
  • Patent number: 10952664
    Abstract: A mobile apparatus is adapted to be handheld and configured for electronic processing of blood sugar affecting factors includes a first central processing unit arranged for processing of patient critical information objects, at least one memory comprising a plurality of in advance stored food units and values of at least one related blood sugar affecting parameter, an input unit arranged to provide user input such as a choice of food units and an amount thereof, a display arranged for visualization of food units for said user input, and for visualization of summed up blood sugar affecting parameters, and a second central processing unit arranged for processing of patient non-critical information objects.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: March 23, 2021
    Assignee: Cross Technology Solutions AB
    Inventors: Thomas Bergqwist, George Sioustis
  • Patent number: 10937536
    Abstract: The optimal insulin to be delivered by an insulin infusion pump is determined by using a reinforcement learning algorithm aiming to the personalized glucose regulation. The algorithm optimizes the daily basal insulin rate and insulin: carbohydrate ratio for each patient, on the basis of his/her measured glucose profile. The proposed algorithm is able to learn in real-time patient-specific characteristics captured in the daily glucose profile and provide individualized insulin treatment. An automatic and personalized tuning method contributes in the optimisation of the algorithm's performance.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: March 2, 2021
    Assignee: UNIVERSIT√ĄT BERN
    Inventors: Stavroula Mougiakakou, Eleni Daskalaki, Peter Diem
  • Patent number: 10925536
    Abstract: A flexible system capable of utilizing data from different monitoring techniques and capable of providing assistance to patients with diabetes at several scalable levels, ranging from advice about long-term trends and prognosis to real-time automated closed-loop control (artificial pancreas). These scalable monitoring and treatment strategies are delivered by a unified system called the Diabetes Assistant (DiAs) platform. The system provides a foundation for implementation of various monitoring, advisory, and automated diabetes treatment algorithms or methods. The DiAs recommendations are tailored to the specifics of an individual patient, and to the patient risk assessment at any given moment. A central data exchange node or server collects patient data from individual DiAs devices and provides safety assurance, monitoring, telemedicine and database building for the DiAs system.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: February 23, 2021
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventor: Boris P. Kovatchev
  • Patent number: 10927404
    Abstract: This disclosure pertains to a testing method for a target pathogen. The method uses biosensors with particular fluorescence characteristics, such that when the biosensor binds to a target pathogen, a fluorophore may emit light if excited. The biosensor may be an aptamer-based biosensor with a fluorophore reporter and a quencher. The excitation of the fluorophore and the detection of fluorescence may be made through the use of a flashlight source and a camera from a mobile device, such as a smartphone.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: February 23, 2021
    Assignee: 4233999 CANADA INC.
    Inventors: Najeeb Ashraf Khalid, Naqeeb Khalid
  • Patent number: 10898115
    Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: January 26, 2021
    Assignee: DexCom, Inc.
    Inventors: Jason Halac, John Michael Gray, Neal Davis Johnston, Justen Deering England, Peter C. Simpson, Paul V. Neale, Jennifer Blackwell, Maria Noel Brown Wells, Kenneth Pirondini, Andrew Michael Reinhardt, Mark Douglas Kempkey
  • Patent number: RE49466
    Abstract: Methods, reagents, kits and systems are disclosed for determining an analyte in a sample suspected of containing the analyte where all reagents are soluble in aqueous solution. One assay method includes treating a sample suspected of containing the analyte under conditions such that if the analyte is present, an activator is brought into reactive configuration with a chemiluminescent compound to activates it. The sample is also treated with an agent to reduce signal not related to analyte. Finally, the sample is treated with a trigger solution thereby producing light from the activated chemiluminescent compound. No reagents are associated with a surface or other solid phase.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: March 21, 2023
    Assignee: Beckman Coulter, Inc.
    Inventors: Hashem Akhavan-Tafti, Dean G. Binger, Ying Chen, Renuka de Silva, Terri McLernon, James Mendoza, Bruce H. Odegaard, Michael Salvati, Nir Shapir, Wenhua Xie