Involving Glucose Or Galactose Patents (Class 435/14)
  • Patent number: 12293514
    Abstract: The method of labeling an image of cells of a patient, in particular an immunocytochemistry image comprises the following steps. First, a digital image of a stained immunocytochemistry biological sample of the patient is received. Following by the step that a computerized classification of cells in the digital image based on color, shape or texture in the digital image, the digital image is labeled by application of a trained neural network on at least one portion of the digital image which comprises a digital image of one cell classified under a first category during the computerized classification.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: May 6, 2025
    Assignee: UMMON HEALTHTECH
    Inventors: Nathan Vinçon, Louis-Oscar Olivier Félix Morel
  • Patent number: 12292405
    Abstract: The invention disclosed herein relates to a dry sensor for measuring the concentration of an analyte in a liquid beverage sample. Described herein is a novel dry sensor which is able to receive a liquid sample and adjust the pH of the liquid to be suitable for assaying an analyte of interest without the need to add reagents to the sample and/or to perform manually timed operations and able to detect a redox reaction in the presence of a liquid sample. The meter disclosed herein, when connected to the sensor disclosed herein is able to adjust the temperature of the liquid to be suitable for the assay, apply a series of potentials, measure the current at several times, measure the diffusion coefficient of the limiting electrochemical species, calculate the concentration of one or more analytes, and rapidly provide the user with the required information on the liquid sample.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: May 6, 2025
    Inventors: Stanley Zhen-Jin Teo, Peter Michael Newman, Ronald Christopher Chatelier, Luke Robert Cossins, Alastair M. Hodges
  • Patent number: 12287334
    Abstract: The techniques relate to methods and apparatus for sealed fluid chambers. The device includes a sensor chip comprising a set of sensor elements at least partially disposed on a first side of a substrate, wherein each sensor element of the set of sensor elements is configured to sense an analyte and comprises an associated set of through silicon vias (TSVs), each TSV of the set of TSVs extending from an associated portion of the sensor element through the substrate to a second side of the substrate that is opposite the first side. The device includes a fluid chamber proximate to the first side of the substrate and comprising an inner portion in fluid communication with the set of sensor elements, and a sealing member between the fluid chamber and the first side of the substrate.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: April 29, 2025
    Assignee: FemtoDx, Inc.
    Inventor: Pritiraj Mohanty
  • Patent number: 12262493
    Abstract: A sensor assembly for sensing a physiological characteristic of a user includes a power source, a power control switch, and a power latch within a housing. The power control switch is electrically coupled to the power source, and is configured to inhibit delivery of power from the power source to one or more components of the sensor assembly before deployment of the sensor assembly to a user, and deliver power from the power source to the one or more components of the sensor assembly in response to the deployment of the sensor assembly to the user. The power latch is configured to, upon the deployment of the sensor assembly to the user, latch an output of the power control switch to maintain the delivery of power from the power source to the one or more components of the sensor assembly while the sensor assembly is in a deployed state.
    Type: Grant
    Filed: March 18, 2024
    Date of Patent: March 25, 2025
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Jesse M. Hefner, Ellis Garai, Al L. McLevish, Brian J. Ferry, Philip R. Glassel, Paul W. Chevalier, David Y. Choy
  • Patent number: 12252729
    Abstract: The present application discloses an enzymatic electrode system and its applications. The enzymatic electrode system comprises a working electrode, a counter electrode, and an optional reference electrode. The working electrode includes an electrode support substrate and a conductive substrate located at the top of the electrode support substrate. The surface or interior of the conductive substrate contains oxidoreductases, coenzyme reductases, and optional coenzymes. This application utilizes a comprehensive enzymatic electrode system incorporating oxidoreductases, coenzyme reductases, and coenzymes for the detection of specific substances in samples, such as glucose, lactate, ketones, and the like.
    Type: Grant
    Filed: January 23, 2024
    Date of Patent: March 18, 2025
    Assignee: Oxsyns.co
    Inventors: Yilin Fan, Beichen Cheng, Yu Sun
  • Patent number: 12234498
    Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.
    Type: Grant
    Filed: August 11, 2022
    Date of Patent: February 25, 2025
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Tianmei Ouyang, Benjamin J. Feldman
  • Patent number: 12203952
    Abstract: A protocol created in such a format that a series of operations for process targets in the fields of engineering related to living organisms are executable by a robot 10 is acquired (S1). The robot 10 is controlled to implement the operations for the process targets according to the protocol (S2). In order to modify the protocol after the implementation of the operations, modification information on at least one action among basic actions which serve as bases for implementing the operations and is performed on an instrument used by the robot 10 in the operations, and complementary actions which complement the basic actions is acquired (S5). The robot 10 is controlled to produce processed products from the process targets by using the protocol modified based on the modification information (S7).
    Type: Grant
    Filed: March 28, 2021
    Date of Patent: January 21, 2025
    Assignee: KABUSHIKI KAISHA YASKAWA DENKI
    Inventors: Tohru Natsume, Kenji Matsukuma, Sakae Yamaguchi
  • Patent number: 12186076
    Abstract: An example medical device includes an optical sensor, processing circuitry, an antenna, and a power source. The optical sensor includes a light source; a reference optical beacon having a first fluorophore that emits a first fluorescence proportional to a first concentration of a substance proximate the beacon; a test optical beacon having a reagent substrate that reacts with an analyte to produce the substance and a second fluorophore that emits a second fluorescence proportional to a second concentration of the substance proximate the test beacon; and a photodetector to detect the first and second fluorescence. The processing circuitry determines a difference between the first and second fluorescence, which is indicative of the concentration of the analyte. The antenna and power source enable the medical device to operate completely within a biological system for continuous analyte monitoring.
    Type: Grant
    Filed: February 9, 2021
    Date of Patent: January 7, 2025
    Assignee: Medtronic, Inc.
    Inventors: David L. Probst, Mark R. Boone
  • Patent number: 12173350
    Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which are capable of detecting or imaging, more specifically, determining the presence, or measuring the level, of proteases, as well as compositions and uses thereof.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: December 24, 2024
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Doron Shabat, Michal Eli Roth-Konforti
  • Patent number: 12165373
    Abstract: A method to assess a subject diagnosis is provided. The method includes receiving an image from an image-capturing device, the image comprising an area of interest in a test cartridge, and finding a border of the area of interest of the test cartridge and applying a geometrical transformation on an area delimited by the border of the test cartridge to bring the image of the area of interest in the test cartridge to a selected size and a selected shape. The method also includes identifying a target region within the area of interest of the test cartridge, evaluating a quality of the image based on a characteristic feature of the target region, and providing commands to adjust an optical coupling in the image-capturing device when the quality of the image is lower than a selected threshold.
    Type: Grant
    Filed: August 25, 2023
    Date of Patent: December 10, 2024
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Houman Yaghoubi, Curtis Marsh, Scott Rongey, Ziad Salem, Adonis Stassinopoulos
  • Patent number: 12146878
    Abstract: A reagent test paddle includes a contamination detection medium, a reference color bar, at least one chemical test medium, and a unique identifier. The contamination detection medium includes a reagent that changes color in the presence or when exposed to a hostile or inhospitable environment. Each chemical test medium includes a regent that is responsive to a respective analyte in a biological sample. The reference color bar includes reference color samples of different colors. The unique identifier, like a serial number, identifies the particular paddle and its chemical test medium so it can be uniquely and anonymously associated with a user.
    Type: Grant
    Filed: August 1, 2023
    Date of Patent: November 19, 2024
    Assignee: HEALTHY.IO LTD.
    Inventors: Bernard Burg, Martin Zizi, Walter De Brouwer, Jaime Tenedorio, Babak Aghazadeh, Jie Cui, Sheena Menezes
  • Patent number: 12128215
    Abstract: Embodiments of the present disclosure relate to approaches for more efficiently measuring glucose levels using a wearable drug delivery device. In some embodiments, the wearable drug delivery device may include a needle deployment component including a cannula and an optical conduit deployable into a user, the cannula operable to deliver a liquid drug to the user. The wearable drug delivery device may further include a glucose monitor including an optical sensor, the optical sensor operable to measure a light output received via the optical conduit.
    Type: Grant
    Filed: September 28, 2021
    Date of Patent: October 29, 2024
    Assignee: INSULET CORPORATION
    Inventors: Steven Cardinali, David Nazzaro, Ian McLaughlin
  • Patent number: 12123046
    Abstract: The purpose of the present invention is to provide a fungus-derived FADGDH that has a direct electron transfer ability. Provided is a fusion protein comprising a fungus-derived FADGDH or a mutant thereof and a cytochrome molecule connected to the N-terminus of the FADGDH or variant thereof.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: October 22, 2024
    Assignees: ULTIZYME INTERNATIONAL LTD., I-SENS, INC.
    Inventors: Koji Sode, Youngjea Kang, Kazushige Mori, Katsuhiro Kojima, Junko Shimazaki
  • Patent number: 12082918
    Abstract: The invention relates to medicine, particularly to agents for magnetic resonance diagnostics for oncological diseases. Developed for this purpose are a diagnostic preparation and a diagnostic method based on using said diagnostic preparation, in which a deuterated derivative of 2-amino-2-methylpropionic acid or 2-(N-methylamino)-2-methylpropionic acid and/or a pharmaceutically acceptable salt thereof, or a mixture of at least two deuterated derivatives of 2-amino-2-methylpropionic acid and/or 2-(N-methylamino)-2-methylpropionic acid and/or the pharmaceutically acceptable salt thereof is used as said preparation. The method according to the invention includes conducting magnetic resonance imaging and/or magnetic resonance spectroscopy on deuterium nuclei at a time after administration of the diagnostic preparation sufficient for the diagnostic preparation to accumulate in the tumor tissue of a subject in order to produce a magnetic resonance image and/or a magnetic resonance spectrum accordingly.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: September 10, 2024
    Assignee: SOLVEX LIMITED LIABILITY COMPANY
    Inventors: Aleksei Valerievich Lesiv, Pavel Evgenievich Ivashkin, Mikhail Vladimirovich Gulyaev, Evgeniya Olegovna Dorofeeva, Aleksei Viktorovich Kosenkov, Mikhail Valentinovich Kiselevsky, Vladimir Ivanovich Polshakov
  • Patent number: 12070308
    Abstract: A glucose monitoring system includes a sensor control device comprising an analyte sensor coupled with sensor electronics, the sensor control device configured to transmit data indicative of an analyte level, and a reader device comprising a wireless communication circuitry configured to receive the data indicative of the analyte level, and one or more processors coupled with a memory.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: August 27, 2024
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Panganamala Ashwin Kumar, Timothy C. Dunn
  • Patent number: 12072331
    Abstract: A chromogenic absorbent material for an animal litter includes an oxidizing agent responsive to peroxidatic/pseudoperoxidatic activity in an animal excretion or a first catalytic compound generating the oxidizing agent in situ. The material also includes a chromogenic indicator being chromogenically responsive to the oxidizing activity of the oxidizing agent, and an absorptive material which is porous, for absorbing the animal excretion. The absorptive material includes a water-absorbing polysaccharide providing absorptive properties to the chromogenic absorbent material; and may also include a second polysaccharide and a superabsorbent polymer. The material may be obtained in the form of particles having a low density and a high porosity, and is usable in conjunction with an animal litter for detecting various diseases in animals.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: August 27, 2024
    Assignee: 7905122 CANADA INC.
    Inventor: Paul Jollez
  • Patent number: 12049566
    Abstract: The present invention provides a method for preserving a leuco chromogen-containing aqueous solution comprising: adding at least one acid compound selected from the group consisting of a phosphoric acid compound, a carboxylic acid compound, a sulfonic acid compound, and a sulfuric acid compound to a leuco chromogen-containing aqueous solution; a method for stabilizing a leuco chromogen in an aqueous solution comprising: adding at least one acid compound selected from the group consisting of a phosphoric acid compound, a carboxylic acid compound, a sulfonic acid compound, and a sulfuric acid compound to a leuco chromogen-containing aqueous solution; and a liquid reagent comprising a leuco chromogen and at least one acid compound selected from the group consisting of a phosphoric acid compound, a carboxylic acid compound, a sulfonic acid compound, and a sulfuric acid compound.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: July 30, 2024
    Assignee: HITACHI CHEMICAL DIAGNOSTICS SYSTEMS CO., LTD.
    Inventors: Haruyo Soya, Yuki Katayama
  • Patent number: 12029557
    Abstract: Data about concentration of one or more types of molecules present within a human body are determined noninvasively using radio frequency signals. Signals at several different frequencies at very low power levels are emitted using an antenna mounted to a wearable device. The antenna includes nested elements of different sizes. Operating values, such as changes to the impedance of the antenna, are associated with the concentration of one or more types molecules within the user. Concentrations at different depths may be measured by using different sets of the nested elements at different times. Operating values at those times are measured and used to determine information indicative of concentration of the molecules. During use, a long axis of the antenna may be aligned with a long axis of a user's arm.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: July 9, 2024
    Assignee: AMAZON TECHNOLOGIES, INC.
    Inventors: Justin Christopher Kenny, Adrian Napoles, Andreas Caduff, Christopher Raymond Grajewski, David Heckerman
  • Patent number: 12023150
    Abstract: An implantable micro-biosensor includes at least one counter electrode, a first working electrode, a chemical reagent layer, and at least one second working electrode. The chemical reagent layer reacts with an analyte to product a product, such that a first sensing section of the first working electrode is driven to perform a measurement action. A second sensing section of the second working electrode is driven to perform an interference-eliminating action to consume interference. The second working electrode cooperates with the counter electrode to permit the counter electrode to be driven to perform a regeneration action to regenerate silver halide.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: July 2, 2024
    Assignee: BIONIME CORPORATION
    Inventors: Chun-Mu Huang, Chieh-Hsing Chen
  • Patent number: 12013343
    Abstract: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port and a cartridge for input to the cartridge receiving port. An optical detection system in the housing is capable of providing an illuminated electric field useful for Raman spectroscopy. The cartridge may have a sample well. The sample well is loaded with a mixture of water containing the analyte, Raman-scattering nanoparticles and a calibration solution. The calibration solution contains an analogue of the analyte differing in its Raman response, for example an isotope of the analyte. Optionally, a chemical compound capable of increasing interaction between the analyte and the nanoparticles may be added.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: June 18, 2024
    Assignee: OndaVia, Inc.
    Inventor: Mark Charles Peterman
  • Patent number: 11986819
    Abstract: The present invention is directed to a method for the preparation of a non-living micro/nanoscale biosynthetic device capable of giving an information of a state of a system to analyse. Preferably, said device is used as an assay diagnostic, or to predict the risk, of a disease, or for the classification of mammal, preferably human pathologies. The invention also relates to a method for the identification and/or the quantification of a compound in a sample. Finally the present invention includes a kit comprising the biosynthetic device obtained by the method of the present invention.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: May 21, 2024
    Assignees: SKILLCELL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CHU MONTPELLIER
    Inventors: Franck Molina, Alexis Courbet, Francisco Santos Schneider
  • Patent number: 11971415
    Abstract: Devices, kits, and methods related to embodiments of an improved liquid test sample injection device comprising a sample mixture that comprises at least one sample flag compound for detecting the presence or non-presence of a patient's liquid test sample upon being interrogated by a pre-determined wavelength of light.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: April 30, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Aaron Kauffmann
  • Patent number: 11952320
    Abstract: An aqueous solution (20) containing carbohydrate for generating smoke consists of 91.9-98.95 wt % of pure water, 1-8 wt % of carbohydrate, and 0.05-0.1 wt % of a water soluble aromatic substance of orange flavor. A method for generating smoke includes preparing an aqueous solution (20) including 91.9-98.95 wt % of pure water, 1-8 wt % of carbohydrate, and 0.05-0.1 wt % of a water soluble aromatic substance of orange flavor; and vibrating the aqueous solution (20) at a high frequency, causing gradual atomization from a surface of the aqueous solution (20) to form droplets containing the carbohydrate and having a diameter in a range of 6-20 ?m.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: April 9, 2024
    Assignee: NOVACORP INC.
    Inventor: Ming-Cheng Chang
  • Patent number: 11918355
    Abstract: Apparatus, methods, and systems for detecting alcohol concentrations of an individual, and in particular in vivo alcohol concentrations of an individual. Alcohol sensing compositions include at least one alcohol-responsive active area comprising a concerted enzyme system having at least a first enzyme and second enzyme capable of acting in concert to facilitate the detection of alcohol. At least one of the enzymes in the concerted enzyme system is a ketoreductase.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: March 5, 2024
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Tianmei Ouyang, Ahmed Hisham Wali
  • Patent number: 11883126
    Abstract: Systems and methods are provided to calibrate an analyte concentration sensor within a biological system, generally using only a signal from the analyte concentration sensor. For example, at a steady state, the analyte concentration value within the biological system is known, and the same may provide a source for calibration. Similar techniques may be employed with slow-moving averages. Variations are disclosed.
    Type: Grant
    Filed: October 26, 2022
    Date of Patent: January 30, 2024
    Assignee: Dexcom, Inc.
    Inventors: Arturo Garcia, Peter C Simpson, Apurv U Kamath, Naresh C. Bhavaraju, Stephen J. Vanslyke
  • Patent number: 11839601
    Abstract: A cannabis-enriched enzymatically treated therapeutic composition. A therapeutic composition is described including water, glucose, glucose reaction product other than sucrose and fructose; a selected amount of a cannabinoid, a cannabinoid reaction product; optionally a terpene and optionally a terpene reaction product. Methods of making and using the compositions are also described.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: December 12, 2023
    Assignee: CANNA-B CURE LTD
    Inventor: Aharon M. Eyal
  • Patent number: 11842817
    Abstract: A method, system and computer readable medium for tracking changes in average glycemia in diabetes is based on a conceptually new approach to the retrieval of SMBG data. Using the understanding of HbA1c fluctuation as the measurable effect of the action of an underlying dynamical system, SMBG provides occasional glimpses at the state of this system and, using these measurements, the hidden underlying system trajectory can be reconstructed for individual diabetes patients. Using compartmental modeling a new two-step algorithm is provided that includes: (i) real-time estimate of HbA1c from fasting glucose readings, updated with any new incoming fasting SMBG data point(s), and (ii) initialization and calibration of the estimated HbA1c trace with daily SMBG profiles obtained periodically. The estimation of these profiles includes a factorial model capturing daily BG variability within two latent factors.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: December 12, 2023
    Assignee: University of Virginia Patent Foundation
    Inventors: Boris P. Kovatchev, Marc D. Breton
  • Patent number: 11821022
    Abstract: An analyte biosensor is provided having an analyte biosensing layer and an ethylene oxide absorption layer. The ethylene oxide absorption layer is provided over the analyte biosensing layer. A method is also provided.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: November 21, 2023
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Robert McKinlay, Chi-En Lin, Tri T. Dang
  • Patent number: 11793471
    Abstract: A method and system for monitoring the effectiveness of a patient's diabetes treatment plan by predicting, on a frequent basis, the patient's glycated hemoglobin (A1c) based on the patient's blood glucose (BG) may include applying a plurality of A1c models to a BG data set of the patient so as to obtain a plurality of calculated A1c values and identifying a best fit model amongst the plurality of A1c models by evaluating the plurality of calculated A1c values against at least one measured A1c value; calculating a predicted A1c value by applying the identified best fit model to the BG data set. Some embodiments may further include evaluating the predicted A1c value against a set of escalation rules to determine whether an escalation alert is required; alerting the patient's healthcare provider when it is determined the escalation alert is required; and outputting the predicted A1c value to the patient.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: October 24, 2023
    Inventor: Sidney Soong-Ling Chan
  • Patent number: 11783563
    Abstract: A method to assess a subject diagnosis is provided. The method includes receiving an image from an image-capturing device, the image comprising an area of interest in a test cartridge, and finding a border of the area of interest of the test cartridge and applying a geometrical transformation on an area delimited by the border of the test cartridge to bring the image of the area of interest in the test cartridge to a selected size and a selected shape. The method also includes identifying a target region within the area of interest of the test cartridge, evaluating a quality of the image based on a characteristic feature of the target region, and providing commands to adjust an optical coupling in the image-capturing device when the quality of the image is lower than a selected threshold.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: October 10, 2023
    Assignee: Quidel Corporation
    Inventors: Houman Yaghoubi, Curtis Marsh, Scott Rongey, Ziad Salem, Adonis Stassinopoulos
  • Patent number: 11740247
    Abstract: This document relates to methods and materials for assessing and/or treating obese mammals (e.g., obese humans). For example, methods and materials for using one or more interventions (e.g., one or more pharmacological interventions) to treat obesity and/or obesity-related comorbidities in a mammal (e.g., a human) identified as being likely to respond to a particular intervention (e.g., a pharmacological intervention) are provided.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: August 29, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Andres J. Acosta, Michael L. Camilleri
  • Patent number: 11726077
    Abstract: A method is provided for calibrating impedance-spectroscopic biomass sensors that are embodied to detect information regarding the quantity and/or size of living cells in a biomass by means of an electric field having a periodically changing field direction A calibration suspension encompasses an electrically conductive viscously flowable or viscoelastic carrier substance and electrically conductive solid particles and/or solid semiconductor particles received therein. An electric field is generated having a periodically changing field direction, which acts on the calibration suspension. At least one permittivity value is detected, respectively representing a permittivity of the calibration suspension, in a context of at least two electric fields having different field direction change frequencies. A difference value is ascertained that represents a difference between the detected permittivity values. The difference value is compared with a reference value associated with the calibration suspension.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: August 15, 2023
    Assignee: HAMILTON BONADUZ AG
    Inventors: Marlene Frank, Philipp Arquint, Theo Gaupp
  • Patent number: 11666216
    Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: June 6, 2023
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Axel Scherer, Peter A Petillo, Samson Chen, Azita Emami
  • Patent number: 11635334
    Abstract: Embodiments described herein are directed to a temperature measurement device that includes a sensor body configured to be placed on a skin of a user. The temperature measurement device can include a first section defining a first lower surface and having a first thickness, a second section defining a second lower surface and having a second thickness, and a channel separating the first lower surface from the second lower surface. The temperature measurement device can also include a first set of temperature sensors positioned across the first thickness, a second set of temperature sensors positioned across the second thickness, and a processor configured to estimate a tissue temperature of the user based on comparing temperature signals from the first set of temperature sensors with temperature signals from the second set of temperature sensors.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: April 25, 2023
    Assignee: Apple Inc.
    Inventors: Helia Rahmani, Anthony D. Minervini, Wanfeng Huang, James C. Clements, Jiandong Yu, Zijing Zeng, Charley T. Ogata
  • Patent number: 11629368
    Abstract: The present application discloses a planar enzyme sensor for measuring the concentration of an analyte in a solution comprising a substrate of an electrically insulating material supporting an electrode layer of an electrically conductive material. The substrate and electrode layer have a plurality of layers disposed thereon which include an enzyme layer and a microporous outer layer covering the enzyme layer, wherein the outer layer comprises a continuous phase of a water-resistant polymer (e.g. a polyvinylacetate or an acrylate copolymer), a protein (e.g. an enzyme) embedded in the continuous phase, and possibly polytetrafluoroethylene particles. The enzyme and the polytetrafluoroethylene particles provide a controlled porosity to the outer membrane.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: April 18, 2023
    Assignee: RADIOMETER MEDICAL APS
    Inventors: Thomas Kjaer, Thomas Steen Hansen, Lydia Dahl Clausen
  • Patent number: 11590243
    Abstract: The present invention relates to the formulation of adenoviral vectors in sorbitol containing compositions in combination with a further amorphous sugar, its formulation as well as a method for obtaining a dried composition.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: February 28, 2023
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Erwan Bourles, Olivier Despas, Delphine Guillaume, Frederic Mathot, Mathieu Vasselle
  • Patent number: 11567012
    Abstract: A mold sensor is configured with an enclosed chamber in which a nutrient-treated substrate is positioned. The mold sensor includes a sensing system that is configured to measure a property of the substrate that corresponds to a pH value of the substrate. A controller operates the sensing system and is programmed to detect a presence of mold growing in the chamber by estimating the pH value from the measured property.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: January 31, 2023
    Assignee: Robert Bosch GmbH
    Inventors: Seow Yuen Yee, Franz Laermer, Thomas Rocznik, Ning Wang
  • Patent number: 11567062
    Abstract: A computer-implemented method for providing a real-time estimate of glycosylated hemoglobin (HbA1c) of a patient from a self-monitoring blood glucose (SMBG) measurement, and tracking changes in average glycemia of said patient over time is disclosed.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: January 31, 2023
    Assignee: University of Virginia Patent Foundation
    Inventors: Boris P. Kovatchev, Marc D. Breton
  • Patent number: 11531025
    Abstract: Provided herein are methods and materials that allow targeting and imaging of interactions between probes and targets. In some embodiments, the probes include nanoscale materials with embedded solutions that can be used to measure physical enhancement by materials under X-ray irradiation. In some embodiments, the methods of the present invention include delivering a probe material to a target that can have a delivered donor material. In some embodiments, methods of the present invention include irradiating the target and determining an optical change in the probe characteristic of a physical enhancement.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: December 20, 2022
    Assignee: The Regents of the University of California
    Inventor: Ting Guo
  • Patent number: 11517231
    Abstract: A blood glucose test strip includes a base substrate, a calibration site, a test site and a non-volatile memory. The calibration site is disposed on the base substrate. A chemical reagent is applied on the calibration site. The test site is disposed on the base substrate. A chemical reagent is applied on the test site. The non-volatile memory is disposed on the base substrate. A calibration parameter is stored in the non-volatile memory. During a calibrating procedure, the calibration solution is dropped on the calibration site, a calibration parameter is calculated according to a first reaction result of the calibration solution and the chemical reagent, and the calibration parameter is stored in the non-volatile memory.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: December 6, 2022
    Assignee: EMEMORY TECHNOLOGY INC.
    Inventor: Hsin-Chou Liu
  • Patent number: 11484258
    Abstract: A method for obtaining an index for non-invasively identifying NASH is provided. A NASH determination method comprising a method for acquiring free radical consumption speed information by non-invasively detecting a redox reaction in a liver of a test animal in real time, comprises a step (1) of obtaining free radical concentration data by applying a magnetic resonance method to the liver as a measurement target after administering a probe into a body; a step (2) of obtaining imaging information by processing the obtained free radical concentration data; and a step (3) of obtaining a free radical consumption speed by kinetically measuring the imaging information over time, and comprises a step of determining whether or not the test animal has NASH, based on the free radical consumption speed information obtained through application to the test animal.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: November 1, 2022
    Assignee: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Masaharu Murata, Fuminori Hyodo, Makoto Hashizume, Ryosuke Nakata, Tomohiko Akahoshi
  • Patent number: 11455724
    Abstract: Systems and methods are disclosed for adjusting attributes of whole slide images, including stains therein. A portion of a whole slide image comprised of a plurality of pixels in a first color space and including one or more stains may be received as input. Based on an identified stain type of the stain(s), a machine-learned transformation associated with the stain type may be retrieved and applied to convert an identified subset of the pixels from the first to a second color space specific to the identified stain type. One or more attributes of the stain(s) may be adjusted in the second color space to generate a stain-adjusted subset of pixels, which are then converted back to the first color space using an inverse of the machine-learned transformation. A stain-adjusted portion of the whole slide image including at least the stain-adjusted subset of pixels may be provided as output.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: September 27, 2022
    Assignee: PAIGE.AI, Inc.
    Inventors: Navid Alemi, Christopher Kanan, Leo Grady
  • Patent number: 11442035
    Abstract: A method of depositing reagent on an electrochemical test sensor adapted to determine information relating to an analyte includes providing a base and forming an electrode pattern on the base. The method further includes depositing the reagent on at least the electrode pattern using a reagent-dispensing system. The reagent-dispensing system applies mechanical force to the reagent in the reagent-dispensing system to assist in providing a wet reagent droplet on at least the electrode pattern.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: September 13, 2022
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Boru Zhu, Herbert Henley, Jr.
  • Patent number: 11433088
    Abstract: Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: September 6, 2022
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Douglas R. Seals, Lindsey Gano, Natalie Poliektor
  • Patent number: 11412962
    Abstract: Systems, methods, and devices of a health device network may include: a non-invasive glucometer that non-invasively measures analyte levels; an invasive glucometer communicatively coupled directly to the non-invasive glucometer; a cloud-based server communicatively coupled to the non-invasive glucometer or the invasive glucometer; a user device communicatively coupled to the cloud-based server; and/or a user interface that displays the invasive glucose measurement, the non-invasive glucose measurement, a data batch, and/or processed data to the user. The non-invasive glucometer and/or the invasive glucometer may aggregate an invasive glucose measurement and a non-invasive glucose measurement into the data batch.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: August 16, 2022
    Inventors: David Miller, Devin Miller, Michael Jones, David Derrick
  • Patent number: 11408778
    Abstract: An electronic device housing encloses a temperature sensing system including a temperature sensor and a differential temperature probe. The differential temperature probe includes a flexible substrate defining two ends. A first end is thermally coupled to the temperature sensor and a second end is thermally coupled to a surface, volume, or component of the electronic device. The temperature probe is an in-plane thermopile including a series-coupled set of thermocouples extending from the first end to the second end. A temperature measured at the temperature sensor can be a first measured temperature and a voltage difference across leads of the differential temperature probe can be correlated to a differential temperature relative to the first measured temperature. A sum of the differential temperature and the first measured temperature is a second measured temperature, quantifying a temperature of the second end of the differential temperature probe.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: August 9, 2022
    Assignee: Apple Inc.
    Inventors: James C. Clements, Chad A. Bossetti, Habib S. Karaki, Paul Mansky
  • Patent number: 11402384
    Abstract: The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Grant
    Filed: November 19, 2016
    Date of Patent: August 2, 2022
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Malin J. Allert
  • Patent number: 11399745
    Abstract: Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: August 2, 2022
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, Mark Brister, Matthew Wightlin, Jack Pryor
  • Patent number: 11389765
    Abstract: The present disclosure relates to a transport mechanism apparatus for transporting at least one of a gas or a fluid. The transport mechanism may have an inlet, an outlet and a triply periodic minimal surface (TPMS) structure. The TPMS structure is formed in a layer-by-layer three dimensional (3D) printing operation to include cells propagating in three dimensions, where the cells include wall portions having openings, and where the cells form a plurality of flow paths throughout the transport mechanism from the inlet to the outlet, and where the cells form the inlet and the outlet.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: July 19, 2022
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Pratanu Roy, Du Nguyen, Joshuah K. Stolaroff
  • Patent number: RE49466
    Abstract: Methods, reagents, kits and systems are disclosed for determining an analyte in a sample suspected of containing the analyte where all reagents are soluble in aqueous solution. One assay method includes treating a sample suspected of containing the analyte under conditions such that if the analyte is present, an activator is brought into reactive configuration with a chemiluminescent compound to activates it. The sample is also treated with an agent to reduce signal not related to analyte. Finally, the sample is treated with a trigger solution thereby producing light from the activated chemiluminescent compound. No reagents are associated with a surface or other solid phase.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: March 21, 2023
    Assignee: Beckman Coulter, Inc.
    Inventors: Hashem Akhavan-Tafti, Dean G. Binger, Ying Chen, Renuka de Silva, Terri McLernon, James Mendoza, Bruce H. Odegaard, Michael Salvati, Nir Shapir, Wenhua Xie