Involving Glucose Or Galactose Patents (Class 435/14)
  • Patent number: 10307437
    Abstract: This invention is about the compositions and methods for assessing and treating vascular endothelial dysfunction. Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject. In one embodiment the dose is administered to subjects in response to the indicator. In another embodiment the dose is administered chronically to subjects.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: June 4, 2019
    Assignee: The Regents of the University of Colorado, a Body Corporate
    Inventors: Douglas R. Seals, Lindsey Gano, Natalie Poliektor
  • Patent number: 10240184
    Abstract: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: March 26, 2019
    Assignee: Promega Corporation
    Inventors: Keith V. Wood, Georgyi V. Los, Robert F. Bulleit, Dieter Klaubert, Mark McDougall, Chad Zimprich
  • Patent number: 10214556
    Abstract: A method for purifying a salt of reduced form of ?-nicotinamide adenine dinucleotide (NADH) includes: sequentially microfiltrating and nanofiltrating a reaction solution obtained after an enzymatic reaction, collecting a concentrate for use; adding an ion pair reagent to the concentrate, and purifying by gradient elution to obtain a purified filtrate using a reverse-phase chromatographic column as a stationary phase, a buffer solution as a phase A, and ethanol as a phase B; changing the cations in the purified filtrate into sodium ions to obtain a filtrate by using a cation exchange resin; and nanofiltrating the filtrate, and freeze drying in a vacuum freeze drier. The method results in an excellent purity and yield of a salt of NADH that meets requirements in industry.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: February 26, 2019
    Assignee: BONTAC BIO-ENGINEERING (SHENZHEN) CO., LTD
    Inventors: Rongzhao Fu, Zhu Dai, Qi Zhang
  • Patent number: 10214552
    Abstract: A method for purifying ?-nicotinamide mononucleotide (NMN) includes: sequentially microfiltrating and nanofiltrating a crude product solution containing NMN using membrane concentration devices to obtain a concentrated crude product solution; adjusting the concentrated crude product solution to pH 3-7 to obtain a loading solution, loading the loading solution onto a preparative reverse phase high performance liquid chromatographic column, and purifying by gradient elution using an octadecylsilane-bonded silica gel as a stationary phase, a hydrochloric acid solution at pH 3-7 as a mobile phase A, and 100% ethanol as a mobile phase B, to obtain a purified sample solution; concentrating the purified sample solution by nanofiltration and freeze drying in a vacuum freeze drier to obtain a purified NMN.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: February 26, 2019
    Assignee: BONTAC BIO-ENGINEERING (SHENZHEN) CO., LTD.
    Inventors: Rongzhao Fu, Zhu Dai, Qi Zhang
  • Patent number: 10168371
    Abstract: A system for determining the impact of moisture on a dielectric sealing material may include a testing apparatus having a testing chamber. A dielectric sealing material and a conducting pin may be exposed to the testing chamber. A first electrical lead may be coupled to the conducting pin, and a second electrical lead may be coupled to the dialectic material. An insulation resistance measurement unit may be coupled to both the first electrical lead and the second electrical lead, and the insulation resistance measurement unit may be configured to measure an insulation resistance value between the electrical leads. The insulation resistance measurement unit may measure a first insulation resistance value of the dielectric sealing material in a first environmental condition, and the insulation resistance measurement unit may measure a second insulation resistance value of the dielectric sealing material at a second environmental condition, that is different than the first environmental condition.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: January 1, 2019
    Assignee: PA&E, HERMETIC SOLUTIONS GROUP, LLC
    Inventors: Hua Xia, Tucker Havekost, Daniel Brown, Erich Preissler, Mike Grimm
  • Patent number: 10130454
    Abstract: This document provides vaccine delivery devices and methods for vaccinating an animal (e.g., a mammal). For example, vaccine delivery devices that include a container having one or more openings, a vaccine depot located within the container, and a diffusion barrier located within the container in a manner such that material (e.g., an antigenic vaccine component) within the vaccine depot must pass through the diffusion barrier before reaching one of the openings are provided.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: November 20, 2018
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Douglas E. Jones, Matthew Brewer, Balaji Narasimhan, John Jackman
  • Patent number: 10077432
    Abstract: A flavin-conjugated glucose dehydrogenase which is composed of proteins having the following amino acid sequence (a), (b) or (c), and having glucose dehydrogenase activity: (a) an amino acid sequence represented by SEQ ID NO: 2, 3, 5, 6, 8 or 9; (b) an amino acid sequence in which one or more amino acids are deleted from, replaced in or added to the amino acid sequence represented by SEQ ID NO: 2, 3, 5, 6, 8 or 9; (c) an amino acid sequence having at least 85% identity with the amino acid sequence represented by SEQ ID NO 2 or 3, at least 95% identity with the amino acid sequence represented by SEQ ID NO 5 or 6, or at least 80% identity with the amino acid sequence represented by SEQ ID NO 8 or 9.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: September 18, 2018
    Assignee: IKEDA FOOD RESEARCH CO., LTD.
    Inventors: Takafumi Takumi, Mizuki Shigeshiro, Daisuke Sato
  • Patent number: 10036708
    Abstract: Methods, reagents, kits and systems are disclosed for determining an analyte in a sample suspected of containing the analyte where all reagents are soluble in aqueous solution. One assay method includes treating a sample suspected of containing the analyte under conditions such that if the analyte is present, an activator is brought into reactive configuration with a chemiluminescent compound to activates it. The sample is also treated with an agent to reduce signal not related to analyte. Finally, the sample is treated with a trigger solution thereby producing light from the activated chemiluminescent compound. No reagents are associated with a surface or other solid phase.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: July 31, 2018
    Assignee: Beckman Coulter, Inc.
    Inventors: Hashem Akhavan-Tafti, Dean G. Binger, Ying Chen, Renuka De Silva, Terri McLernon, James Mendoza, Bruce H. Odegaard, Michael Salvati, Nir Shapir, Wenhua Xie
  • Patent number: 10028691
    Abstract: A needle assembly. The needle assembly enabling the analysis of fluid trapped in a flashback chamber after an insertion needle has been inserted into a patient's vein.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: July 24, 2018
    Assignee: Smiths Medical ASD, Inc.
    Inventors: David Goral, Harsh Chheda, Jay Breindel, Gursel Akcay, James Muskatello, David Justmann
  • Patent number: 10024817
    Abstract: Electrochemical biosensing devices and methods detect the activity of proteases and active infection in biological samples. The devices and methods utilize distance constraints between a redox reporter and an electrode to create a change in current that is detected. The distance constraints are released when an analyte containing a specified protease or proteases reacts with a protein substrate sequence in the analyte. The particular protease or proteases to be detected can be selected by using biosensors with particular substrate sequences. The devices and methods are not only qualitative, they can be used to quantitatively evaluate protease content in samples.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: July 17, 2018
    Assignee: PeloGenix, LLC
    Inventors: Mark R. Wardell, Kenneth A. Sabacinski
  • Patent number: 10012657
    Abstract: Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described. Generally, the nanosensors comprise a photoluminescent nanostructure and a polymer that interacts with the photoluminescent nanostructure. In some cases, the interaction between the polymer and the nanostructure can be non-covalent (e.g., via van der Waals interactions). The nanosensors comprising a polymer and a photoluminescent nanostructure may be particularly useful in determining the presence and/or concentration of relatively small molecules, in some embodiments. In addition, in some instances the nanosensors may be capable of determining relatively low concentrations of analytes, in some cases determining as little as a single molecule. In some embodiments, the interaction between the analyte and the nanosensor (e.g.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: July 3, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Jong-Ho Kim, Jinqing Zhang, Daniel A. Heller
  • Patent number: 9993187
    Abstract: A sensor arrangement for detecting information indicative of a physiological substance in a body material of a physiological subject, wherein the sensor arrangement comprises a substrate, a first sensor structure connected to the substrate and being configured for sensing the physiological substance electrochemically, and a second sensor structure connected to the substrate and being configured for sensing the physiological substance by a luminescence detection.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: June 12, 2018
    Assignee: JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH & CO. KG
    Inventor: Martin Hajnsek
  • Patent number: 9982289
    Abstract: A test strip or electrochemical sensor for measuring the amount of an analyte in a biological fluid, e.g. the glucose content of whole blood, includes a size self-limiting reagent formulation employing an enzyme system for reaction with the analyte, the reactive system mixed into a water-soluble swellable polymer matrix containing small water-insoluble particles having a nominal size of about 0.05 to 20 ?m, preferably about 1 to 10 ?m. The weight ratio of the water-insoluble particles to the water-soluble swellable polymer matrix is about 1/2 to 2/1. The reagent formulation is deposited onto a non-porous substrate to form a thin layer about 6-16 ?m thick, providing a rapid and stable response to application of a sample, while being insensitive to the amount of the sample.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: May 29, 2018
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventor: Karen L. Marfurt
  • Patent number: 9931065
    Abstract: The present embodiments relate generally to systems and methods for measuring an analyte in a host. More particularly, the present embodiments provide sensor applicators and methods of use with pushbutton activation that implant the sensor, withdraw the insertion needle, engage the transmitter with the housing, and disengage the applicator from the housing, all in one smooth motion. Some embodiments contemplate engagement of the transmitter with the housing after release of the applicator.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 3, 2018
    Assignee: DeXCom, Inc.
    Inventors: Jack Pryor, Sebastian Bohm, David DeRenzy, Jason Halac, Daniel S. Kline, Phong Lieu, Adam J. Livingston, Steve Masterson, Paul V. Neale, Peter C. Simpson, Antonio Joao Ubach
  • Patent number: 9915567
    Abstract: An unreleased thermopile IR sensor and method of fabrication is provided which includes a new thermally isolating material and an ultra-thin material based sensor which, in combination, provide excellent sensitivity without requiring a released membrane structure. The sensor is fabricated using a wafer transfer technique in which a substrate assembly comprising the substrate and new thermally isolating material is bonded to a carrier substrate assembly comprising a carrier substrate and the ultra-thin material, followed by removal of the carrier substrate. As such, temperature restrictions of the various materials are overcome.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: March 13, 2018
    Assignee: Excelitas Technologies Singapore Pte. Ltd.
    Inventors: Piotr Kropelnicki, Radu M. Marinescu, Grigore D. Huminic, Hermann Karagoezoglu, Kai Liang Chuan
  • Patent number: 9907500
    Abstract: The present invention is directed to membranes composed liquid crystals having continuous aqueous channels, such as a lyotropic liquid crystal, including a cubic phase lyotropic liquid crystal, and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes of the present invention demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: March 6, 2018
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Adam Heller, Pawel Rowinski, Benjamin J. Feldman
  • Patent number: 9908115
    Abstract: A microfluidic device can include a base an outer surface of which forms one or more enclosures for containing a fluidic medium. The base can include an array of individually controllable transistor structures each of which can comprise both a lateral transistor and a vertical transistor. The transistor structures can be light activated, and the lateral and vertical transistors can thus be photo transistors. Each transistor structure can be activated to create a temporary electrical connection from a region of the outer surface of the base (and thus fluidic medium in the enclosure) to a common electrical conductor. The temporary electrical connection can induce a localized electrokinetic force generally at the region, which can be sufficiently strong to move a nearby micro-object in the enclosure.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: March 6, 2018
    Assignee: Berkeley Lights, Inc.
    Inventors: Eric D. Hobbs, Justin K. Valley
  • Patent number: 9897920
    Abstract: The present disclosure relates to a sensor for detecting saccharide and manufacturing method thereof and detection method of glycated hemoglobin using the same wherein the sensor for detecting saccharide includes a reactive layer synthesized with hydrogel having a boronic acid-modified 3D mesh structure. A selective and sensitive detection of the glycated protein including glucose or glycated hemoglobin (HbA1c) in blood through high level of signal may be enabled, and the durability of the sensor for detecting saccharide may be enhanced.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: February 20, 2018
    Assignees: LG ELECTRONICS INC., AJOU UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION
    Inventors: Yunhee Ku, Moosub Kim, Yongju Yang, Seung Yeon Song, Kang Sun Lee, Hyun Chul Yoon, Yong Duk Han, Yoo Min Park
  • Patent number: 9855359
    Abstract: Analyte sensors capable of undergoing sterilization with ethylene oxide are provided. The analyte sensors can include one or more polymer membranes having a nucleophilic group.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: January 2, 2018
    Assignee: Verily Life Sciences LLC
    Inventor: Zenghe Liu
  • Patent number: 9850379
    Abstract: Gels and gel-containing materials, including hydrogels, are described. A gel can be formed by blending polyacrylic acid (PAA) and a polyglycol, such as polytetramethylene ether glycol (PTMEG) at room temperature and, in some cases, without using a catalyst. The blend material can be used to form soft or hard materials, films and particles. The blend material can be combined with vinyl monomers and polymerize to form a hydrogel. The hydrogel can have a high mechanical strength and high water absorbency.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: December 26, 2017
    Inventors: Naihong Li, Michael C. Williams
  • Patent number: 9828621
    Abstract: Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and determining whether at least one output transient signal of the biosensor is erroneous by monitoring the biosensor and flagging an error if the signal outputs of the biosensor do not meet certain criteria.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: November 28, 2017
    Assignee: LifeScan Scotland Limited
    Inventor: Stephen Mackintosh
  • Patent number: 9796963
    Abstract: The present invention provides a novel glucose dehydrogenase that has excellent substrate specificity and that is suitable for use in SMBG. The present invention provides a flavin-bound glucose dehydrogenase having the following characteristics (1) to (5): (1) Temperature stability: stable at a temperature of 45° C. or lower; (2) stable at a pH range of 4.5 to 7.5; (3) substrate specificity: the reactivity to D-xylose, maltose, or D-galactose is 2% or less, based on the reactivity to D-glucose taken as 100%; (4) optimal activity temperature: 34 to 47° C.; and (5) optimal activity pH: 6.3 to 6.7.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: October 24, 2017
    Assignee: Toyobo Co., Ltd.
    Inventors: Yasuhiro Yamazaki, Yosuke Sumida, Rie Hirao, Yuu Utashima, Hiroshi Aiba, Takahide Kishimoto, Shusaku Yanagidani
  • Patent number: 9777154
    Abstract: Gels and gel-containing materials, including hydrogels, are described. A gel can be formed by blending polyacrylic acid (PAA) and a polyglycol, such as polytetramethylene ether glycol (PTMEG) at room temperature and, in some cases, without using a catalyst. The blend material can be used to form soft or hard materials, films and particles. The blend material can be combined with vinyl monomers and polymerize to form a hydrogel. The hydrogel can have a high mechanical strength and high water absorbency.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: October 3, 2017
    Inventors: Naihong Li, Michael C. Williams
  • Patent number: 9772302
    Abstract: An improved quality assurance system and method for point-of-care testing are disclosed. The present invention provides quality assurance for laboratory quality tests performed by a blood analysis system or the like at the point of patient care without the need for running liquid-based quality control materials on the analysis system. Quality assurance of a quantitative physiological sample test system is performed without using a quality control sample by monitoring the thermal and temporal stress of a component used with the test system. Alert information is generated that indicates that the component has failed quality assurance when the thermal and temporal stress exceeds a predetermined thermal-temporal stress threshold. Alternatively, the present invention provides quality assurance for laboratory quality tests performed by a blood analysis system or the like at the point of patient care by minimizing the need for running liquid-based quality control materials on the analysis system.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: September 26, 2017
    Assignee: Abbott Point of Care Inc.
    Inventors: Michael P. Zelin, Eric Brouwer, Steven Breeze
  • Patent number: 9739746
    Abstract: An analyte sensor and a method for making the analyte sensor are disclosed. The analyte sensor includes a crosslinked, hydrophilic copolymer having a methacrylate-derived backbone and a side chain having a negatively charged group. The copolymer can include an embedded analyte sensing component, and can be adjacent to a surface of an electrode, or be adjacent to a sensing membrane that that has an embedded analyte sensing component and is adjacent to a surface of an electrode. The sensing membrane can have a crosslinked network of crosslinked proteins.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: August 22, 2017
    Assignee: Google Inc.
    Inventors: Zenghe Liu, Huanfen Yao
  • Patent number: 9719955
    Abstract: A hematocrit (HCT) measurement system and measurement method using the same are disclosed. The hematocrit (HCT) measurement system comprises a test strip and a measurement apparatus comprising: a connector transmitting an initial signal generated from a blood sample to the measurement apparatus, a capacitive reactance adjustor disposed between the test strip and the measurement apparatus, a calculation unit for calculating concentration and HCT value of the blood sample, an A/D convertor transforming the corresponding initial signal to a digital signal, and a signal processor processing the digital reacted signal and showing measured results on a display, wherein the HCT value is calculated by voltage partition to prevent the signal waveform voltage being saturated or cutoff, thereby resulting in measured signal distortion.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: August 1, 2017
    Assignee: Apex Biotechnology Corp.
    Inventors: Chu-Ming Cheng, Lee Teng Yi Wu, Ching-Yuan Chu
  • Patent number: 9689832
    Abstract: In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base, a first electrode and a second electrode wherein a thermocouple portion is provided integral with the second electrode thereby enabling on-sensor temperature measurement capability. In some embodiments, two and only two electrical contact engagement portions are provided thereby simplifying electrical contact. Manufacturing methods and systems utilizing the analyte sensors are provided, as are numerous other aspects.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: June 27, 2017
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Hoi-Cheong Steve Sun, John P. Creaven, Mu Wu, Paul M. Ripley, Steven C. Charlton
  • Patent number: 9670525
    Abstract: Provided is a method for measuring cholesterol in high-density lipoprotein (HDL) simply and accurately. A method for measuring cholesterol in high-density lipoprotein in a specimen, comprising reacting the specimen with i) a cholesterol ester hydrolase and a cholesterol oxidase, or ii) a cholesterol ester hydrolase, an oxidized coenzyme, and a cholesterol dehydrogenase, in an aqueous medium comprising at least one substance selected from the group consisting of pyridinium salts and quaternary ammonium salts each having a specific structure, and a polyanion to form hydrogen peroxide or reduced coenzyme and measuring the formed hydrogen peroxide or reduced coenzyme.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: June 6, 2017
    Assignee: KYOWA MEDEX CO., LTD.
    Inventors: Rie Utsugi, Yuki Katayama
  • Patent number: 9663811
    Abstract: An object of the present invention is to provide: a novel gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase having excellent properties that it has excellent reactivity to glucose, excellent thermal stability, and excellent substrate-recognition performance and also has a low activity for maltose; a process for the production of the enzyme using a transformant cell transfected with the gene; and a method for the determination of glucose, a reagent composition for use in the determination of glucose, a biosensor for use in the determination of glucose and others, each characterized by using the enzyme obtained.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: May 30, 2017
    Assignee: Ikeda Food Research Co., Ltd.
    Inventors: Takako Yada, Koji Miyamoto, Michinari Honda
  • Patent number: 9606115
    Abstract: There is provided a lateral flow immunoassay test device. The test device comprises a test strip. The test strip comprises a test membrane having a translucent section including a control zone and a test zone. The device is adapted to house the test strip such that at least the translucent section is exposable to ambient light. The device comprises a backing structure for backing the test strip which comprises a first optical detector for detecting ambient light which has passed through the test zone, and a second optical detector for detecting ambient light which has passed through the translucent section in a further zone outside of the test and control zones. Using the detector outputs an amount of analyte in a test liquid may be calculated.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: March 28, 2017
    Assignee: NXP B.V.
    Inventors: Viet Hoang Nguyen, Filip Frederix, Axel Nackaerts, Youri Victorovitch Ponomarev
  • Patent number: 9574198
    Abstract: The present invention relates to novel bacteria and the uses thereof. The invention particularly relates to bacteria having a metabolic pathway ratio between pentose phosphate and glycolysis greater than 0.5, and their uses in the chemical, pharmaceutical and agro-chemical industries, e.g., for producing compounds of industrial interest.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: February 21, 2017
    Assignee: DEINOVE
    Inventors: Jean-Paul Leonetti, Juha-Pekka Pitkanen, Paula Jouhten
  • Patent number: 9575056
    Abstract: The present invention relates to a strip for an improved lateral flow assay of a biological sample on a single plane and a lateral flow chromatography assay using a test device containing the same. The strip of the present invention consists of a single-pad, which can improve lateral flow assay by providing an easy and simple procedure and clear visual reading. The strip of the present invention is consisted of sample application (sample) zone and reactant-resultant zone where the reaction mixture is deposited (reactant) are all on a same plane. In addition, the present invention provides a chromatographic method wherein hemoglobin is separated from analyte by a differential chromatography on the solid phase. Any interference of detection of the result by hemoglobin is removed by the present invention. The present invention provides advantages including an easy and simple procedure with a quick and clear response.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: February 21, 2017
    Assignee: ACCESS BIO, INC.
    Inventors: Hyeon Suk Kim, Tae-Hee Koo, Young Ho Choi
  • Patent number: 9547000
    Abstract: A chromogenic absorbent material and related chromogenic solution, use, process and application for an animal litter. The chromogenic absorbent material includes an absorptive material for absorbing an animal excretion; an oxidizing agent responsive to peroxidatic/pseudoperoxidatic activity in the animal excretion to provide oxidizing activity; and an inclusion complex including a host compound and a guest compound, the guest compound being a chromogenic indicator associated with the host compound and being chromogenically responsive to the oxidizing activity of the oxidizing agent. The chromogenic absorbent material may be prepared from the chromogenic solution including the oxidizing agent and the inclusion complex. The chromogenic absorbent material may be used as particles combined with animal litter for detection of peroxidatic/pseudoperoxidatic activity in the animal excretion.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 17, 2017
    Assignee: 7905122 Canada Inc.
    Inventors: Marie-Cleo Gravel-Lacroix, Paul Jollez, Isabelle Bolduc
  • Patent number: 9538056
    Abstract: This disclosure provides systems, devices, and methods for capturing and measuring surface topography. This disclosure provides a high resolution retrographic sensor comprising a volume of elastomer and a thin, opaque reflective membrane. The reflective membrane is arranged to conform to a specimen that contacts it. The disclosure provides a high resolution visualization system comprising the retrographic sensor and an illumination source. Also provided are high resolution measurement systems comprising the retrographic sensor, an illumination source, an imaging device, and a processing component.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: January 3, 2017
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Edward H. Adelson, Micah K. Johnson
  • Patent number: 9528977
    Abstract: Storage containers for storing at least one diagnostic test element including an enzyme and a stabilized coenzyme are disclosed. In addition, diagnostic products which include diagnostic test elements including an enzyme and a stabilized coenzyme, as well as analytical measuring devices which include such storage containers or diagnostic products, are also disclosed. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving test elements which include an enzyme and a stabilized coenzyme.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: December 27, 2016
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Carina Horn, Christian Freitag, Hans-Peter Haar, Heino Eikmeier
  • Patent number: 9528963
    Abstract: Provided is a buffer composition capable of suppressing temperature dependency of the pH of a buffer solution, and a specimen analysis method and a specimen analysis system using the buffer composition, wherein the buffer composition contains a buffer substance A showing a positive correlation between temperature and pH and a buffer substance B showing a negative correlation between temperature and pH.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: December 27, 2016
    Assignee: ARKRAY, Inc.
    Inventors: Naotsugu Onuma, Miho Fukuda
  • Patent number: 9512459
    Abstract: Amino acid mutation(s) can be introduced to Sclerotinia sclerotiorum- or Aspergillus niger-derived glucose dehydrogenase to obtain a glucose dehydrogenase variant with significantly enhanced productivity in E. coli. The glucose dehydrogenase of the present invention is low reactive with xylose.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: December 6, 2016
    Assignee: ULTIZYME INTERNATIONAL LTD.
    Inventors: Koji Sode, Kazushige Mori
  • Patent number: 9500618
    Abstract: Described and illustrated herein are systems and exemplary methods of operating an analyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a first test voltage between a reference electrode and a second working electrode and applying a second test voltage between the reference electrode and a first working electrode; measuring a first test current, a second test current, a third test current and a fourth test current at the second working electrode after a blood sample containing an analyte is applied to the test strip; measuring a fifth test current at the first working electrode; estimating a hematocrit-corrected analyte concentration from the first, second, third, fourth and fifth test currents; and annunciating the hematocrit-corrected analyte concentration.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: November 22, 2016
    Assignee: LifeScan Scotland Limited
    Inventors: Michael Malecha, Adam Craggs
  • Patent number: 9487758
    Abstract: An object of the present invention is to provide a novel glucose dehydrogenase, a method for producing the glucose dehydrogenase, and applications of the glucose dehydrogenase. An isolated flavin-binding glucose dehydrogenase comprising a polypeptide having an amino acid sequence with 80% or more identity to the amino acid sequence of SEQ ID NO: 1, and having glucose dehydrogenase activity is provided.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: November 8, 2016
    Assignee: Toyobo Co., Ltd.
    Inventors: Yosuke Sumida, Hiroshi Aiba, Hiroshi Kawaminami, Rie Hirao, Yuu Utashima, Takahide Kishimoto, Shusaku Yanagidani
  • Patent number: 9469844
    Abstract: A heat-resistant flavin-bound glucose dehydrogenase having a high substrate specificity for D-glucose, an method for producing the same, and a transformant used for the same. A flavin-bound glucose dehydrogenase gene encoding a flavin-bound glucose dehydrogenase derived from Mucor is introduced into yeast, Zygosaccharomyces, to obtain a transformant. Subsequently, the yeast transformant is cultured to obtain a flavin-bound glucose dehydrogenase from the culture. The heat-resistant flavin-bound glucose dehydrogenase is less susceptible to the effects of dissolved oxygen and allows accurate measurement of glucose even in the presence of sugar compounds other than glucose in a sample.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: October 18, 2016
    Assignee: KIKKOMAN CORPORATION
    Inventors: Ryoko Tajima, Atsushi Ichiyanagi, Kozo Hirokawa, Masanobu Yuzuki
  • Patent number: 9458434
    Abstract: An object is to provide a novel enzyme that exhibits glucose dehydrogenase activity. Furthermore, another object is to provide a novel method pertaining to enzyme modification. Provided is a mutated enzyme containing an amino acid sequence wherein one or at least two amino acids selected from a group are substituted with another amino acid in the amino acid sequence of a microorganism-derived glucose oxidase.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: October 4, 2016
    Assignee: AMANO ENZYME INC.
    Inventors: Kyoichi Nishio, Satoshi Koikeda
  • Patent number: 9435815
    Abstract: The present invention relates to a method for determining the presence, absence or amount of biologically active HGF in a sample, comprising the steps (i) bringing the sample in contact with a first porous solid phase comprising a HGF binding component of the extracellular matrix or cell membrane, and an indicator composition comprising bromothymol blue and a quaternary ammonium compound; and (ii) correlating the color of the porous solid phase with the presence, absence or amount of biologically active HGF in the sample. It further relates to a device comprising a first porous solid phase comprising at least one HGF-binding component of the extracellular matrix or cell membrane, and an indicator composition comprising bromothymol blue and a quaternary ammonium compound.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: September 6, 2016
    Assignee: PEAS INSTITUT AB
    Inventors: Fariba Nayeri, Kamal Bahar
  • Patent number: 9410917
    Abstract: A biosensor (102) for determining the presence or amount of a substance in a sample and methods of use of the biosensor (102) are provided. The biosensor (102) for receiving a user sample to be analyzed includes a mixture for electrochemical reaction with an analyte. The mixture includes an enzyme, a mediator and an oxidizable species as an internal reference.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: August 9, 2016
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Greg P. Beer, Huan-Ping Wu, Kin-Fai Yip
  • Patent number: 9364177
    Abstract: A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: June 14, 2016
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Rajiv Shah, Rebecca K. Gottlieb
  • Patent number: 9354181
    Abstract: An analytical device, in particular, a paper analytical device (PAD), for detection of at least two chemical components indicative of a low quality pharmaceutical product is provided. The analytical device can include a porous, hydrophilic medium, at least two assay regions associated with the porous, hydrophilic medium, at least one assay reagent or precursor thereof in the assay regions, and at least one optically readable information zone.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: May 31, 2016
    Assignees: Saint Mary's College, University of Notre Dame du Lac
    Inventors: Toni Lee Owen Barstis, Patrick Joseph Flynn, Marya Lieberman
  • Patent number: 9303279
    Abstract: A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol)diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: April 5, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Adam Heller, Benjamin J. Feldman, Nicolas Mano, Yueh-Lin Loo
  • Patent number: 9267166
    Abstract: The invention provides methods of treating ?-galactosidase A deficiency. Dosage forms, methods of administration, and methods of analyzing human ?-galactosidase A are also included.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: February 23, 2016
    Assignee: SHIRE HUMAN GENETIC THERAPIES, INC.
    Inventors: Douglas A. Treco, Kenneth Loveday, Marianne Borowski
  • Patent number: 9187779
    Abstract: Systems and methods for oxygen removal from aqueous solutions are presented in which a bi-enzymatic reaction sequence recycles and depletes oxygen to extinction, preferably using an oxidase and a catalase as biocatalysts and a carbohydrate as co-substrate. Contemplated systems and methods are particularly advantageous in conjunction with electrochemical reaction systems in which oxygen would adversely interfere with the reaction system.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: November 17, 2015
    Assignee: The Nitrate Elimination Co., Inc.
    Inventors: Nicolas Plumere, Wilbur H. Campbell, Ellen R. Campbell
  • Patent number: 9189598
    Abstract: A device for managing health data provides a first housing portion including a data storage system that stores health data and a second housing portion including a data communications element. The data communications element provides data communications between the data storage system and a processing device that processes the health data according to a data-management software. The first housing portion and the second housing portion are connected by a cable that communicates signals between the data communications element and other components in the first housing portion. Another device for managing health data provides a first housing portion including a health data management system and a data communications element that provides data communications between the health data management system and an external processing device. The second housing portion is removably coupled to the first housing portion, and includes at least one component used by the health data management system.
    Type: Grant
    Filed: March 9, 2013
    Date of Patent: November 17, 2015
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Darren Brown, Jun Chen, Igor Gofman, Steven B. Harris, Paul L. Inman, Richard Kates, Qiong Li, Harris Lieber, Paul M. Ripley, Gregory Stefkovic, Hoi-Cheong Steven Sun, Mu Wu, Raymond Yao, Simin Yao
  • Patent number: 9181389
    Abstract: A polymer colorant including polymer monomer units, and at least one alizarin unit which is incorporated into the polymer and which provides color to the polymer colorant and a process for preparing the polymer colorant. An article or composition containing the polymer colorant. A toner including the polymer colorant, and optionally, one or more ingredients selected from the group consisting of crystalline polyester resins, amorphous polyester resins, colorants, waxes, coagulants, mordants, and mixtures and combinations thereof. A polymer latex including an aqueous dispersion of polymer colorant, wherein the polymer colorant comprises polymer monomer units and at least one alizarin unit which is incorporated into the polymer and which provides color to the polymer colorant; and optionally, a mordant.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: November 10, 2015
    Assignee: Xerox Corporation
    Inventors: Valerie M. Farrugia, Mihaela Maria Birau, Gabriel Iftime, Biby Esther Abraham