Involving Glucose Or Galactose Patents (Class 435/14)
  • Patent number: 11517231
    Abstract: A blood glucose test strip includes a base substrate, a calibration site, a test site and a non-volatile memory. The calibration site is disposed on the base substrate. A chemical reagent is applied on the calibration site. The test site is disposed on the base substrate. A chemical reagent is applied on the test site. The non-volatile memory is disposed on the base substrate. A calibration parameter is stored in the non-volatile memory. During a calibrating procedure, the calibration solution is dropped on the calibration site, a calibration parameter is calculated according to a first reaction result of the calibration solution and the chemical reagent, and the calibration parameter is stored in the non-volatile memory.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: December 6, 2022
    Assignee: EMEMORY TECHNOLOGY INC.
    Inventor: Hsin-Chou Liu
  • Patent number: 11484258
    Abstract: A method for obtaining an index for non-invasively identifying NASH is provided. A NASH determination method comprising a method for acquiring free radical consumption speed information by non-invasively detecting a redox reaction in a liver of a test animal in real time, comprises a step (1) of obtaining free radical concentration data by applying a magnetic resonance method to the liver as a measurement target after administering a probe into a body; a step (2) of obtaining imaging information by processing the obtained free radical concentration data; and a step (3) of obtaining a free radical consumption speed by kinetically measuring the imaging information over time, and comprises a step of determining whether or not the test animal has NASH, based on the free radical consumption speed information obtained through application to the test animal.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: November 1, 2022
    Assignee: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Masaharu Murata, Fuminori Hyodo, Makoto Hashizume, Ryosuke Nakata, Tomohiko Akahoshi
  • Patent number: 11455724
    Abstract: Systems and methods are disclosed for adjusting attributes of whole slide images, including stains therein. A portion of a whole slide image comprised of a plurality of pixels in a first color space and including one or more stains may be received as input. Based on an identified stain type of the stain(s), a machine-learned transformation associated with the stain type may be retrieved and applied to convert an identified subset of the pixels from the first to a second color space specific to the identified stain type. One or more attributes of the stain(s) may be adjusted in the second color space to generate a stain-adjusted subset of pixels, which are then converted back to the first color space using an inverse of the machine-learned transformation. A stain-adjusted portion of the whole slide image including at least the stain-adjusted subset of pixels may be provided as output.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: September 27, 2022
    Assignee: PAIGE.AI, Inc.
    Inventors: Navid Alemi, Christopher Kanan, Leo Grady
  • Patent number: 11442035
    Abstract: A method of depositing reagent on an electrochemical test sensor adapted to determine information relating to an analyte includes providing a base and forming an electrode pattern on the base. The method further includes depositing the reagent on at least the electrode pattern using a reagent-dispensing system. The reagent-dispensing system applies mechanical force to the reagent in the reagent-dispensing system to assist in providing a wet reagent droplet on at least the electrode pattern.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: September 13, 2022
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Boru Zhu, Herbert Henley, Jr.
  • Patent number: 11433088
    Abstract: Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: September 6, 2022
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Douglas R. Seals, Lindsey Gano, Natalie Poliektor
  • Patent number: 11412962
    Abstract: Systems, methods, and devices of a health device network may include: a non-invasive glucometer that non-invasively measures analyte levels; an invasive glucometer communicatively coupled directly to the non-invasive glucometer; a cloud-based server communicatively coupled to the non-invasive glucometer or the invasive glucometer; a user device communicatively coupled to the cloud-based server; and/or a user interface that displays the invasive glucose measurement, the non-invasive glucose measurement, a data batch, and/or processed data to the user. The non-invasive glucometer and/or the invasive glucometer may aggregate an invasive glucose measurement and a non-invasive glucose measurement into the data batch.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: August 16, 2022
    Inventors: David Miller, Devin Miller, Michael Jones, David Derrick
  • Patent number: 11408778
    Abstract: An electronic device housing encloses a temperature sensing system including a temperature sensor and a differential temperature probe. The differential temperature probe includes a flexible substrate defining two ends. A first end is thermally coupled to the temperature sensor and a second end is thermally coupled to a surface, volume, or component of the electronic device. The temperature probe is an in-plane thermopile including a series-coupled set of thermocouples extending from the first end to the second end. A temperature measured at the temperature sensor can be a first measured temperature and a voltage difference across leads of the differential temperature probe can be correlated to a differential temperature relative to the first measured temperature. A sum of the differential temperature and the first measured temperature is a second measured temperature, quantifying a temperature of the second end of the differential temperature probe.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: August 9, 2022
    Assignee: Apple Inc.
    Inventors: James C. Clements, Chad A. Bossetti, Habib S. Karaki, Paul Mansky
  • Patent number: 11399745
    Abstract: Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: August 2, 2022
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, Mark Brister, Matthew Wightlin, Jack Pryor
  • Patent number: 11402384
    Abstract: The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Grant
    Filed: November 19, 2016
    Date of Patent: August 2, 2022
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Malin J. Allert
  • Patent number: 11391723
    Abstract: The present disclosure provides methods of processing data provided by a transcutaneous or subcutaneous analyte sensor utilizing different algorithms to strike a balance between signal responsiveness accompanied by signal noise and the introduction of error associated with that noise. The methods utilize the strengths of a lag correction algorithm and a smoothing algorithm to optimize the quality and value of the resulting data (glucose concentrations and the rates of change in glucose concentrations) to a continuous glucose monitoring system. Also provided are systems and kits.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: July 19, 2022
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Wesley Scott Harper, Erwin Satrya Budiman, Kenneth J. Doniger, Gary Alan Hayter
  • Patent number: 11389765
    Abstract: The present disclosure relates to a transport mechanism apparatus for transporting at least one of a gas or a fluid. The transport mechanism may have an inlet, an outlet and a triply periodic minimal surface (TPMS) structure. The TPMS structure is formed in a layer-by-layer three dimensional (3D) printing operation to include cells propagating in three dimensions, where the cells include wall portions having openings, and where the cells form a plurality of flow paths throughout the transport mechanism from the inlet to the outlet, and where the cells form the inlet and the outlet.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: July 19, 2022
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Pratanu Roy, Du Nguyen, Joshuah K. Stolaroff
  • Patent number: 11389117
    Abstract: An apparatus for predicting hypoglycemia according to an exemplary embodiment of the present disclosure is an apparatus for predicting hypoglycemia, which predicts the occurrence of postprandial hypoglycemia using blood glucose-related information, wherein the blood glucose-related information includes a blood glucose level at a reference time, a blood glucose change rate over a duration from a mealtime to a postprandial peak blood glucose level time, a blood glucose change rate over a duration from the postprandial peak blood glucose level time to the reference time, and a blood glucose change rate at the reference time.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: July 19, 2022
    Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Sung Min Park, Won Ju Seo, Seung Hyun Lee
  • Patent number: 11375930
    Abstract: An electronic device for obtaining biometric information is provided. The electronic device includes at least one communication circuit, a first pad including a first electrode and a second electrode, the first electrode being coated with a catalyst associated with first biometric information, a second pad including at least a third electrode, and a processor for controlling the at least one communication circuit, the first pad, and the second pad. The processor is configured to obtain the first biometric information, based at least on an electric current generated by applying a specified voltage between the first electrode and the second electrode and obtain second biometric information, based at least on a voltage difference between the second electrode and the third electrode.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: July 5, 2022
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Injo Jeong, Hyunguk Yoo, Kunkook Park, Seungeun Lee
  • Patent number: 11378574
    Abstract: The present invention relates to a method for detecting a target substance that is useful for detection of a glycoprotein and the like comprising a specific sugar chain, a reagent for detecting a target substance, a carrier and a method for manufacturing the carrier.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: July 5, 2022
    Assignee: SYSMEX CORPORATION
    Inventors: Chikayuki Tsuruno, Shinya Nagai, Minako Terao, Chika Mizuta, Takuya Kyoutou
  • Patent number: 11278600
    Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH<4.5) and basic (pH>7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: March 22, 2022
    Assignee: Codexis, Inc.
    Inventors: Nicholas J. Agard, Mathew G. Miller, Xiyun Zhang, Gjalt W. Huisman
  • Patent number: 11215578
    Abstract: In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base, a first electrode and a second electrode wherein a thermocouple portion is provided integral with the second electrode thereby enabling on-sensor temperature measurement capability. In some embodiments, two and only two electrical contact engagement portions are provided thereby simplifying electrical contact. Manufacturing methods and systems utilizing the analyte sensors are provided, as are numerous other aspects.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: January 4, 2022
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Hoi-Cheong Steve Sun, John P. Creaven, Mu Wu, Paul M. Ripley, Steven C. Charlton
  • Patent number: 11197635
    Abstract: A healthcare apparatus according to an embodiment includes: a plurality of light sources configured to emit light of different wavelengths onto an object; a light detector configured to measure an optical signal of each of the wavelengths by receiving light reflected or scattered from the object; and a processor configured to obtain a blood glucose level and a blood flow index by using the optical signal of each of the wavelengths, and to estimate at least one from among dietary information and dietary metabolism state information by monitoring a blood glucose level change and a blood flow index change after ingestion of a food.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: December 14, 2021
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Ka Ram Choi, Hyo Sun Hwang, Jin Young Park, Jae Wook Shim, So Young Lee, Sang Kon Bae, Eui Seok Shin
  • Patent number: 11147486
    Abstract: A one step all-in-one apparatus for body fluid sampling and sensing, comprising: a housing(1), a plurality of integrated sampling and sensing assemblies, a cartridge(12), sealing films(101,102), an upper cover(13), a sampling port(6), a linear actuating mechanism and a control circuit, with every integrated sampling and sensing assembly comprising a micro fluid-sampling needle(2), a needle hub(3) and a test strip(4); the micro fluid-sampling needles(2) penetrate the skin to sample the body fluid and deliver the body fluid to the test strips(4) directly, and changes occurred on the test strips(4) are read by the sensor(5), wherein sampling and sensing are completed in one step.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: October 19, 2021
    Assignee: MEDTRUM TECHNOLOGIES INC.
    Inventor: Cuijun Yang
  • Patent number: 11137387
    Abstract: A method of identifying or evaluating synergistic combinations of actives such as skin-care actives that improve the metabolism of a cell and provides an advantage over using the actives alone. The method includes contacting cells with test agents, alone and in combination, and determining a response of the cells to the test agent(s), wherein the response corresponds to a change in a metabolic indicator associated with glycolysis and a change in a metabolic indicator associated with oxidative phosphylation.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: October 5, 2021
    Assignee: The Procter & Gamble Company
    Inventors: John Erich Oblong, Holly Ann Rovito
  • Patent number: 11123011
    Abstract: Methods, systems, and devices are described herein for various embodiments of using a sample analysis system to analyze a sample of bodily fluid from a user to determine parameters associated with the user including states of hydration, dehydration, rehydration, electrolyte loss, wellness, recovery, and the like. In some embodiments, the methods disclosed can be implemented using a device worn by a user, and operatively coupled to a sample analysis system configured to collect a sample of bodily fluid, and measure and analyze the bodily fluid to determine a property of the bodily fluid and/or a physiological/wellness parameter (e.g., degree of hydration, electrolyte losses, perspiration rate, etc.) of the user.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: September 21, 2021
    Assignee: Nix, Inc.
    Inventors: Shawn Mishra, Kenneth Ritsher, Meridith Unger Cass
  • Patent number: 11104903
    Abstract: The invention relates to nucleic acids and methods for restoring acid alpha-glucosidase (GAA) activity in patients with Pompe disease using splice-switching technology.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: August 31, 2021
    Assignee: SYNTHENA AG
    Inventors: Luis Garcia, Aurelie Avril
  • Patent number: 11092604
    Abstract: The present invention provides a glucose sensor having a glucose receptor containing a binding site of formula (I): wherein X, n, m and R1 are defined herein. Also provided is a glucose sensor molecule for use in such a glucose sensor, the glucose sensor molecule containing the binding site of formula (I). The binding site has been found to have particularly good selectivity for glucose.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: August 17, 2021
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Nicholas Paul Barwell, Tony James
  • Patent number: 11078517
    Abstract: This invention provides an amadoriase that acts on the ?-chain of hemoglobin A1c (HbA1c) and generates hydrogen peroxide, a method for measurement of HbA1c using such amadoriase, and a reagent kit for measurement of HbA1c using such amadoriase. The method for measurement of HbA1c involves the use of an amadoriase that has specific activity of 0.1 U/mg or greater to ?F6P and oxidizes the HbA1c ?-chain amino terminus so as to generate hydrogen peroxide, and the reagent kit for measurement of HbA1c comprises such amadoriase. The method and the kit for measurement of HbA1c enable quantification of HbA1c to be performed rapidly, simply, and accurately.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: August 3, 2021
    Assignee: Kikkoman Corporation
    Inventors: Yosuke Masakari, Atsushi Ichiyanagi
  • Patent number: 11072809
    Abstract: An object of the present invention is to construct a more excellent glucose sensor, and to provide GDH more suitable for the glucose sensor. Provided is FAD-dependent glucose dehydrogenase in which the range of molecular weight distribution observed by SDS-PAGE is within 50 kDa when viewed in a molecular weight distribution in which the relative value of band intensity exceeds 60% of the maximum value.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: July 27, 2021
    Assignee: TOYOBO CO., LTD.
    Inventor: Yuu Utashima
  • Patent number: 11053556
    Abstract: This disclosure pertains to a testing method for a target pathogen. The method uses biosensors with particular fluorescence characteristics, such that when the biosensor binds to a target pathogen, a fluorophore may emit light if excited. The biosensor may be an aptamer-based biosensor with a fluorophore reporter and a quencher. The excitation of the fluorophore and the detection of fluorescence may be made through the use of a flashlight source and a camera from a mobile device, such as a smartphone.
    Type: Grant
    Filed: February 22, 2021
    Date of Patent: July 6, 2021
    Inventors: Najeeb Ashraf Khalid, Naqeeb Khalid
  • Patent number: 10973888
    Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH<4.5) and basic (pH>7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: April 13, 2021
    Assignee: Codexis, Inc.
    Inventors: Nicholas J. Agard, Mathew G. Miller, Xiyun Zhang, Gjalt W. Huisman
  • Patent number: 10956821
    Abstract: Embodiments for accurate temporal event predictive modeling by a processor. An average reverse event delay may be determined from one or more event delays in a time-series window. A time-series event may be predicted by applying the average reverse event delay in conjunction with one or more weighted factors in a predictive model.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: March 23, 2021
    Assignee: International Business Machines Corporation
    Inventors: Charu C. Aggarwal, Lingtao Cao, Tan Hung M. Ng, Saket Sathe, Deepak S. Turaga
  • Patent number: 10952664
    Abstract: A mobile apparatus is adapted to be handheld and configured for electronic processing of blood sugar affecting factors includes a first central processing unit arranged for processing of patient critical information objects, at least one memory comprising a plurality of in advance stored food units and values of at least one related blood sugar affecting parameter, an input unit arranged to provide user input such as a choice of food units and an amount thereof, a display arranged for visualization of food units for said user input, and for visualization of summed up blood sugar affecting parameters, and a second central processing unit arranged for processing of patient non-critical information objects.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: March 23, 2021
    Assignee: Cross Technology Solutions AB
    Inventors: Thomas Bergqwist, George Sioustis
  • Patent number: 10937536
    Abstract: The optimal insulin to be delivered by an insulin infusion pump is determined by using a reinforcement learning algorithm aiming to the personalized glucose regulation. The algorithm optimizes the daily basal insulin rate and insulin: carbohydrate ratio for each patient, on the basis of his/her measured glucose profile. The proposed algorithm is able to learn in real-time patient-specific characteristics captured in the daily glucose profile and provide individualized insulin treatment. An automatic and personalized tuning method contributes in the optimisation of the algorithm's performance.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: March 2, 2021
    Assignee: UNIVERSIT√ĄT BERN
    Inventors: Stavroula Mougiakakou, Eleni Daskalaki, Peter Diem
  • Patent number: 10925536
    Abstract: A flexible system capable of utilizing data from different monitoring techniques and capable of providing assistance to patients with diabetes at several scalable levels, ranging from advice about long-term trends and prognosis to real-time automated closed-loop control (artificial pancreas). These scalable monitoring and treatment strategies are delivered by a unified system called the Diabetes Assistant (DiAs) platform. The system provides a foundation for implementation of various monitoring, advisory, and automated diabetes treatment algorithms or methods. The DiAs recommendations are tailored to the specifics of an individual patient, and to the patient risk assessment at any given moment. A central data exchange node or server collects patient data from individual DiAs devices and provides safety assurance, monitoring, telemedicine and database building for the DiAs system.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: February 23, 2021
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventor: Boris P. Kovatchev
  • Patent number: 10927404
    Abstract: This disclosure pertains to a testing method for a target pathogen. The method uses biosensors with particular fluorescence characteristics, such that when the biosensor binds to a target pathogen, a fluorophore may emit light if excited. The biosensor may be an aptamer-based biosensor with a fluorophore reporter and a quencher. The excitation of the fluorophore and the detection of fluorescence may be made through the use of a flashlight source and a camera from a mobile device, such as a smartphone.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: February 23, 2021
    Assignee: 4233999 CANADA INC.
    Inventors: Najeeb Ashraf Khalid, Naqeeb Khalid
  • Patent number: 10898115
    Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: January 26, 2021
    Assignee: DexCom, Inc.
    Inventors: Jason Halac, John Michael Gray, Neal Davis Johnston, Justen Deering England, Peter C. Simpson, Paul V. Neale, Jennifer Blackwell, Maria Noel Brown Wells, Kenneth Pirondini, Andrew Michael Reinhardt, Mark Douglas Kempkey
  • Patent number: 10883133
    Abstract: The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to FAD to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: January 5, 2021
    Assignees: Ikeda Food Research Co., Ltd., PHC Corporation
    Inventors: Hironori Omura, Hirokazu Sanada, Takako Yada, Ayaka Atsumi, Tetsunari Morita, Emi Ishimaru
  • Patent number: 10877051
    Abstract: The invention provides fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening superoxide. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. The invention further provides fluorogenic compounds for selectively staining superoxide in the mitochondria of living cells. The invention also provides methods that can be used to measure, directly or indirectly, the presence and/or amount of superoxide in chemical samples and biological samples such as cells and tissues in living organisms, and a high-throughput screening methods for detecting or screening superoxide or compounds that can increase or decrease the level of superoxide in chemical and biological samples.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: December 29, 2020
    Assignee: THE UNIVERSITY OF HONG KONG
    Inventors: Dan Yang, Nai-Kei Wong, Jun Hu
  • Patent number: 10871496
    Abstract: Disclosed is a platform detecting glycated hemoglobin as an indicator for diabetes in the blood based on upconverting nanoparticles excited by near-infrared light and luminescence resonance energy transfer.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: December 22, 2020
    Assignee: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Min-Gon Kim, Hyo-Young Mun, Eun-Jung Jo
  • Patent number: 10859571
    Abstract: A method and a system for quantitative or qualitative determination of a target component in a liquid sample includes i) providing a plurality of magnetic particles including one or more capture sites for the target component on their respective surfaces; ii) providing a plurality of fluorophores configured to bind to the capture sites of the magnetic particles; iii) bringing the liquid sample into contact with the fluorophores and the magnetic particles in a flow channel of a micro fluidic device including a transparent window; and iv) at least temporally immobilizing the magnetic particles adjacent to the transparent window using a magnet, emitting exciting electromagnetic beam towards the immobilized magnetic particles, reading signals emitted from fluorophores captured by the immobilized magnetic particles and performing a quantitative or qualitative determination of the target component based on the read signal.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: December 8, 2020
    Assignee: ZOETIS DENMARK ApS
    Inventors: Martin Bak Heller, Bent Overby, Niels Kristian Bau-Madsen
  • Patent number: 10823745
    Abstract: An object of the present invention is to provide a blood test kit and a blood analysis method capable of performing a blood test with a small amount of blood at high accuracy by visualizing a volume of blood collection and keeping the volume constant. According to the present invention, a blood test kit including a diluent solution for diluting components of a blood sample; and at least one transparent container for storing the components of the blood sample and the diluent solution, in which at least one constituent component included in the blood test kit is marked with a graduation for measuring the components of the blood sample and a liquid volume of the diluent solution, is provided.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: November 3, 2020
    Assignee: FUJIFILM Corporation
    Inventors: Seiji Yamashita, Haruyasu Nakatsugawa, Susumu Osawa, Shinya Sugimoto
  • Patent number: 10801066
    Abstract: A method for a determining of risk for development of cardiovascular disease by measuring levels of the at least gene of interest is disclosed. The method may identify subjects with moderate albuminuria and diagnosis or predict cardiovascular disease several years before either of these outcomes is detectable by present methodologies.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: October 13, 2020
    Assignee: American University of Beirut
    Inventors: Kamal F. Badr, Assaad A Eid, Robert H. Habib
  • Patent number: 10781469
    Abstract: The present disclosure provides, inter alia, mediator formulations for the measurement of an analyte comprising at least one ruthenium compound and at least one osmium compound. Also disclosed are reagent formulations for the measurement of an analyte comprising at least one ruthenium compound and at least one osmium compound. Also disclosed are methods and devices for the measurement of an analyte in a sample.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: September 22, 2020
    Assignee: Omni Biomedical, Inc.
    Inventors: David Zhi Deng, Gary T. Neel
  • Patent number: 10752934
    Abstract: The present invention provides a soluble pyrroloquinoline-quinone-dependent glucose dehydrogenase (PQQ-sGDH) mutant, wherein the amino acid positions thereof correspond to a wild-type PQQ-sGDH sequence of Acinetobacter calcoaceticus as shown in SEQ ID NO 1 comprising one of the following group of mutations: A194F, a combined mutation based on A194F, a combined mutation based on Q192A or a combined mutation based on Q192S. Said PQQ-sGDH mutant has good glucose substrate specificity and significantly reduced cross-reactivity to maltose and the like, and is suitable for detecting glucose in a sample such as blood.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: August 25, 2020
    Assignee: LEADWAY (HK) LIMITED
    Inventors: Zhe Wang, Xin Bi, Riyong Qiu
  • Patent number: 10739361
    Abstract: An object of the present invention is to provide a blood analysis method in which a high level of repeatability and reproducibility is achieved with respect to measurement values in a blood sample, and a blood test kit which is used for the blood analysis method.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: August 11, 2020
    Assignee: FUJIFILM Corporation
    Inventors: Tatsuya Ishizaka, Haruyasu Nakatsugawa, Susumu Osawa, Shinya Sugimoto
  • Patent number: 10704073
    Abstract: There is provided a method for easily determining an undifferentiated state of pluripotent stem cells without relying on the judgment of a skilled technician. The method includes: a step of evaluating an undifferentiated state of pluripotent stem cells based on a time-dependent change in a variation value of an extracellular metabolite contained in a culture medium in which the pluripotent stem cells are cultured, wherein the extracellular metabolite is at least one selected from a group consisting of L-glutamic acid, L-alanine and ammonia.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: July 7, 2020
    Assignee: TOKYO ELECTRON LIMITED
    Inventors: Kunitada Hatabayashi, Kentaro Tomita, Shinichi Gomi, Tomoaki Kurakazu, Yasuhiro Oshima, Kenichi Kagawa, Shigenori Ozaki
  • Patent number: 10706524
    Abstract: Systems and methods for analyzing stained fabric articles are provided herein. In an embodiment, a method for analyzing stained fabric articles includes providing a stained fabric article that includes a foreign oily substance disposed in and/or on the fabric article. At least one image of the stained fabric article is captured using a three-dimensional imaging device, wherein the at least one image is captured in the absence of a colored dyes added to the foreign oily substance in and/or on the fabric article. The at least one image is processed using a contrast function to produce a processed data set. One or more of a processed image or a quantitative data set that is representative of oily substance presence in the viewing area of the three-dimensional imaging device is produced based upon the processed data set.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: July 7, 2020
    Assignee: Henkel IP & Holding GmbH
    Inventors: Paul Kichar, Maxime Pelletier, Michelle Avelina Piombino, Joseph David Dahlmeyer, Jr.
  • Patent number: 10702686
    Abstract: A wound oxygen supply system includes a chassis that defines an oxygen outlet. an oxygen production subsystem is included in the chassis and coupled to the oxygen outlet. A control subsystem is coupled to the oxygen production subsystem and configured to receive humidity information that is indicative of a humidity experienced by the oxygen production subsystem. The control system then uses the humidity information to control power provided to the oxygen production subsystem in order to control an oxygen flow that is created by the oxygen production subsystem and provided through the oxygen outlet to a restricted airflow enclosure adjacent a wound site.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: July 7, 2020
    Assignee: Electrochemical Oxygen Concepts, Inc.
    Inventors: Mark Q. Niederauer, James P. Daley, Joseph J. Moffett
  • Patent number: 10697922
    Abstract: Disclosed is a biosensor with improved humidity resistance that can be used as a glucose sensor or a lactate sensor. The biosensor includes: an insulative substrate; an electrode system having a working electrode and a counter electrode provided on the substrate; and a reagent layer provided on the electrode system. The reagent layer contains an oxidoreductase and 1-methoxy-5-methylphenazinium ethyl sulfate. This biosensor can be used as a glucose sensor or a lactate sensor.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: June 30, 2020
    Assignee: ARKRAY, Inc.
    Inventor: Hisashi Kaneda
  • Patent number: 10633453
    Abstract: Disclosed herein is a hinge antibody capable of being selectively activated in a target cell or tissue to treat a condition therein. The hinge antibody includes a functional antibody, two inhibitory domains and four cleavable linkers. The functional antibody is capable of treating the condition in an activated state, and has two light chains and two heavy chains. Each inhibitory domain includes a hinge domain of an immunoglobulin and consists of two peptide arms. Each cleavable linker includes a peptide substrate cleavable by an enzyme specifically or highly expressed in the target cell or tissue, and connects one of the peptide arms of the inhibitory domains to the N-terminal of one of the light chains and heavy chains of the functional antibody. Also disclosed herein are methods for preparing and using this hinge antibody.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: April 28, 2020
    Assignees: KAOHSIUNG MEDICAL UNIVERSITY, DCB-USA LLC
    Inventors: Tian-Lu Cheng, Chih-Hung Chuang, Hsiu-Fen Ko, Yun-Chi Lu
  • Patent number: 10627361
    Abstract: An electrochemical test device for determining a concentration of an analyte in a fluid sample is provided. The electrochemical test device comprises a set of electrodes including a working electrode for the analyte and sensing chemistry for the working electrode, wherein the sensing chemistry comprises a diaphorase, an electron transfer agent having a standard redox potential in the range of ?0.52 to 0.18 V, an NAD(P)+-dependent dehydrogenase and a cofactor for the NAD(P)+-dependent dehydrogenase.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: April 21, 2020
    Assignee: INSIDE BIOMETRICS INTERNATIONAL LIMITED
    Inventors: Marco Cardosi, Stephanie Kirkwood
  • Patent number: 10548537
    Abstract: A testing system and method for providing a testing system includes a user interface having a display for displaying information relating to measurements of health data and an input device for receiving information from a user relating to the health data. Provided in connection with the user interface is an autologging feature adapted to provide the user with user-selectable options on the display. Also provided is a statistical operation adapted to provide the user with enhanced information relating to the measurements of health data. Also provided is at least one indicator for indicating information relating to the number of health data readings that are within a target range, the number of health data readings that are above the target range and the number of health data readings that are below the target range.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: February 4, 2020
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventors: Jacob Brauer, Darren Brown, Jun Chen, Richard Kates, Jennifer M. Levin, Harris Lieber, Amy Schwartz, Raymond Yao
  • Patent number: 10526418
    Abstract: Compositions of modulators of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1) expression, function or activity are provided. In particular, inhibitors of ALCAT1 are useful in treating metabolic diseases, cardiac diseases and, in general diseases associated with mitochondrial dysfunction. Assays for identification of novel ALCAT1 modulators are provided.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: January 7, 2020
    Assignee: The Penn State Research Foundation
    Inventor: Yuguang Shi
  • Patent number: 10510920
    Abstract: A silanized ITO electrode modified with ITO nanoparticles is described. ITO nanoparticles of cubic and semispherical shapes are immobilized on a silanized ITO film. The electrode may be used in an electrolytic cell to detect aqueous sulfide with a 0.5-1.4 ?M limit of detection. The electrode shows high specificity towards aqueous sulfide and a high reproducibility in measurement.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: December 17, 2019
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Md. Abdul Aziz, Zain Hassan Abdallah Yamani