Using Bacteria Patents (Class 435/170)
  • Patent number: 10273502
    Abstract: A process for producing a retroviral or lentiviral vector formulation comprising a filter-sterilisation step wherein the filter-sterilisation step is not the final step in the purification process.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: April 30, 2019
    Assignee: Oxford BioMedica (UK) Limited
    Inventors: Richard Truran, Robert Buckley, Pippa Radcliffe, James Miskin, Kyriacos Mitrophanous
  • Patent number: 10272122
    Abstract: A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhea (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: April 30, 2019
    Assignee: BIOCC OÜ
    Inventors: Marika Mikelsaar, Epp Songisepp, Pirje Hütt, Imbi Smidt, Kai Truusalu, Merle Rätsep, Siiri Koljalg, Jelena Stsepetova, Kalle Kilk, Mihkel Zilmer, Epp Sepp, Raik-Hiio Mikelsaar
  • Patent number: 10227661
    Abstract: Disclosed herein are materials and methods for achieving sequence-specific organism detection and/or phenotype(s) using sequence-specific oligonucleotides. Also disclosed are related kits, cultures, and cells for detecting and/or phenotyping microorganisms in a sequence-specific manner.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: March 12, 2019
    Assignee: GeneWeave Biosciences, Inc.
    Inventor: Diego Ariel Rey
  • Patent number: 10179920
    Abstract: Engineered microorganisms are provided that convert gaseous substrates, such as producer gas, into limonene. In some embodiments, limonene is pumped out of the cell via an efflux pump. In some embodiments, limonene, produced as described herein, is converted through catalytic dimerization into jet fuel. Producer gas used in the processes described herein for production of limonene may be derived from sources that include gasification of waste feedstock and/or biomass residue, waste gas from industrial processes, or natural gas, biogas, or landfill gas.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: January 15, 2019
    Assignee: Kiverdi, Inc.
    Inventors: Christer Jansson, Cody A. Marcus Carr, John S. Reed
  • Patent number: 10092605
    Abstract: A food composition for alleviating hangovers, the food composition contains, as an active ingredient, at least one strain selected from the group consisting of Lactococcus chungangensis, Lactococcus fujiensis, Lactococcus lactis subsp. cremoris, Lactococcus lactis subsp. lactis, and Lactococcus raffinolactis, or a culture liquid thereof culture medium, wherein functional cream cheese is prepared using five species of Lactococcus strains above having the ability to decompose ethanol and acetaldehyde.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: October 9, 2018
    Assignee: CHUNG-ANG UNIVERSITY INDUSTRY-ACADEMY COOPERATION FOUNDATION
    Inventors: Won Yong Kim, Woo Jin Choi, Maytiya Konkit, Sung Lim Cho
  • Patent number: 10081790
    Abstract: Herein a Bacillus exosporium molecule delivery (BEMD) system that provides a means to deliver molecules of interest (MOIs) to an environment is disclosed. The system results in the display of MOIs on the exosporium surface of Bacillus family members such that they can be delivered to an environment in a stable and active form. In addition, methods of making and using the system are described.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: September 25, 2018
    Assignee: The Curators of the University of Missouri
    Inventors: George C. Stewart, Brian Matthew Thompson, Chung-Ho Lin
  • Patent number: 9956283
    Abstract: The disclosed invention provides mammalian milk osteopontin and/or an active truncation or active peptide thereof for improving immune responsiveness to an infectious disease in a mammal, for example a human subject, as well as enhancing the efficacy of vaccination for the prophylactic or therapeutic treatment of an infectious disease in mammals, such as humans. The invention further provides a vaccine system, for use in the prophylactic or therapeutic treatment of an infectious disease in a mammal, comprising a vaccine and a mammalian milk osteopontin and/or an active truncation or active peptide thereof for oral administration to a mammal, as well as methods of enhancing immune resistance to an infectious disease in a mammal by administration of a vaccine and a mammalian milk osteopontin and/or an active truncation thereof.
    Type: Grant
    Filed: July 4, 2014
    Date of Patent: May 1, 2018
    Assignee: Arla Foods AMBA
    Inventors: Anne Staudt Kvistgaard, Peter Langborg Wejse, Sharon Donovan, Marcia H. Monaco Siegel, Sarah S. Comstock
  • Patent number: 9956277
    Abstract: Herein a Bacillus exosporium antigen delivery (BEAD) system that provides a means to introduce recombinant proteins or small molecules into the exosporium of members of the B. cereus family of bacteria, i.e. B. anthracis, B. cereus, and B. thuringiensis, is disclosed. The system results in the surface display of recombinant proteins or small molecules such that they can stimulate an immune response. In addition, methods of making and using the system are described.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: May 1, 2018
    Assignee: The Curators of the University of Missouri
    Inventors: George C. Stewart, Brian Matthew Thompson
  • Patent number: 9951306
    Abstract: The present invention relates to the use of a secreted fungal catalase, for hydrogen-peroxide neutralization in growth media for the detection of microorganisms as well as to a method for detecting microorganisms in hydrogen peroxide-bearing aerosol or on a hydrogen peroxide bearing surface, said method comprising contacting said aerosol or surface with a growth medium comprising a secreted fungal catalase, and detecting growth of microorganisms in said medium.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: April 24, 2018
    Assignee: Eucodis Bioscience GmbH
    Inventors: Werner Besenmatter, Axel Niebisch, Jan Modregger, Bhupinder Hundle
  • Patent number: 9816068
    Abstract: Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides, polypeptides, and proteins with the characteristics and location of the corresponding genes on the host cell chromosome, such as that of E. coli, yeast, Bacillus subtilis or other prokaryotes, insect cells, mammalian cells, etc. This platform quantitatively describes and identifies priority deletions, modifications, or inhibitions of certain gene products to increase chromatographic separation efficiency, defined as an increase in column capacity, column selectivity, or both, with emphasis on the former. Moreover, the platform provides a computerized knowledge tool that, given separatome data and a target recombinant peptide, polypeptide, or protein, intuitively suggests strategies leading to efficient product purification.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: November 14, 2017
    Assignees: The Board of Trustees of the University of Arkansas, University of Pittsburgh-of the Commonwealth System of Higher Learning
    Inventors: Ellen M. Brune, Robert R. Beitle, Jr., Mohammad M. Ataai, Patrick R. Bartlow, Ralph L. Henry
  • Patent number: 9738870
    Abstract: A method for treating a skin disorder, e.g., acne, e.g. acne vulgaris, in a subject is provided. The method comprises administering, e.g., applying, e.g., topically administering, ammonia oxidizing bacteria, e.g., a preparation comprising ammonia oxidizing bacteria, to a surface of the subject. Preparations comprising ammonia oxidizing bacteria for treating such skin disorder, e.g., acne, e.g. acne vulgaris in a subject are also provided.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: August 22, 2017
    Assignee: AOBIOME LLC
    Inventors: David R. Whitlock, Spiros Jamas, Larry Weiss
  • Patent number: 9682932
    Abstract: The present invention relates to a simple and economic method of extracting a crystalline Carotenoid compound, such as Beta-carotene, Lycopene, with a purity of at least 99%. The present invention further describes a process to prepare such a highly pure crystalline Carotenoid compound from microbial biomass, using an Anti-purity compound removal process followed by a mono-solvent extraction method. Further the process describes value addition of the co-products recovered during the extraction process thus resulting in a highly economical industrial method for the production of such high purity crystalline Carotenoids compound.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: June 20, 2017
    Assignee: DYNADIS BIOTECH INDIA PRIVATE LIMITED
    Inventors: Suresh Joseph, Arnaud Anandane
  • Patent number: 9593304
    Abstract: The present invention is related to methods and materials for culturing and transporting stem cells in a three-dimensional culture. The materials comprise cellulose nanofibrils in a form of three-dimensional discontinuous entities in a biocompatible hydrogel.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: March 14, 2017
    Assignee: UPM-KYMMENE CORPORATION
    Inventors: Antti Laukkanen, Yan-Ru Lou, Marjo Yliperttula, Tytti Kuisma, Johanna Nikander, Jaakko Pere
  • Patent number: 9523096
    Abstract: This disclosure describes genetically modified photosynthetic microorganisms, e.g., Cyanobacteria, that overexpress an acyl carrier protein (ACP), an acyl-ACP synthase (Aas), or both, optionally in combination with one or more overexpressed or exogenous lipid biosynthesis proteins, and/or one or more overexpressed or exogenous glycogen breakdown proteins. Exemplary biosynthesis proteins include diacyglycerol acyltransferases, thioesterases, phosphatidate phosphatases, phospholipases, triacylglycerol (TAG) hydrolases, fatty acyl-CoA synthetases, and/or acetyl-CoA carboxylases, including combinations thereof. Also included are photosynthetic microorganisms comprising mutations or deletions in a glycogen biosynthesis or storage pathway, which accumulate a reduced amount of glycogen under reduced nitrogen conditions as compared to a wild type photosynthetic microorganism.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: December 20, 2016
    Assignee: Matrix Genetics, LLC
    Inventors: James Roberts, Fred Cross, Margaret Mary McCormick, Ernesto Javier Munoz, Brett K. Kaiser, Michael Carleton
  • Patent number: 9506086
    Abstract: Engineered microorganisms are provided that convert gaseous substrates, such as producer gas, into limonene. In some embodiments, limonene is pumped out of the cell via an efflux pump. In some embodiments, limonene, produced as described herein, is converted through catalytic dimerization into jet fuel. Producer gas used in the processes described herein for production of limonene may be derived from sources that include gasification of waste feedstock and/or biomass residue, waste gas from industrial processes, or natural gas, biogas, or landfill gas.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: November 29, 2016
    Assignee: Kiverdi, Inc.
    Inventors: Christer Jannson, Cody A. Marcus Carr, John S. Reed
  • Patent number: 9481903
    Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: November 1, 2016
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Diego Ariel Rey, Shaunak Roy, Leonardo Maestri Teixeira, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor Yee
  • Patent number: 9233864
    Abstract: Methods of controlling a nitrification reaction in a biological nitrogen removal reactor to favor partial nitrification of ammonia to nitrite instead of complete oxidation of ammonia to nitrate are disclosed. In some embodiments, the methods include the following: maintaining a pH in the reactor within a range that promotes growth of ammonia oxidizing bacteria; maintaining a concentration of dissolved oxygen in the reactor within a range that limits the ammonia oxidizing bacteria from completing nitrification; selecting an operational solids retention time within a range suitable for maintaining increasing concentrations of the ammonia oxidizing bacteria in the reactor while reducing concentrations of nitrite oxidizing bacteria in the reactor; and increasing a concentration of free ammonia in the reactor thereby inhibiting growth of the nitrite oxidizing bacteria in the reactor.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: January 12, 2016
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Kartik Chandran, Ran Yu, Joon Ho Ahn
  • Patent number: 9187766
    Abstract: A non-therapeutic method of accumulating a polymeric or high molecular weight molecular product within a bacterial microcompartment in bacterial cytoplasm, which method employs a recombinant bacteria which is transformed to express a microcompartment containing an enzyme capable of converting a low molecular weight substrate into a polymeric or high molecular weight product, the method comprising the steps of: incubating the recombinant bacteria with the low-molecular weight substrate, or a precursor of the low molecular weight substrate which is capable of being metabolized to the substrate within the recombinant bacteria, such that the substrate or precursor is taken up by the bacteria, wherein the substrate enters the microcompartment and the enzyme within the microcompartment converts the substrate to a polymeric or high molecular weight molecular product, and wherein the polymeric or high molecular weight molecular product is accumulated within the microcompartment due to its size.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: November 17, 2015
    Assignees: University College Cork, National University of Ireland, University of Kent
    Inventors: Michael Prentice, Martin Warren, Mingzhi Liang
  • Patent number: 9181566
    Abstract: The invention relates to suitable screening strategies for evaluating various candidate promoters for differential gene expression during the propagation and production phases of a fermentation process. The invention also relates to recombinant host cells that comprise identified promoter nucleic acid sequences and methods for producing fermentation products employing the same.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: November 10, 2015
    Assignee: BUTAMAX ADVANCED BIOFUELS LLC
    Inventors: Michael Dauner, Arthur Leo Kruckeberg, Robert A Larossa, Brian James Paul, Wonchul Suh, Joseph Frederich Tuminello
  • Patent number: 9012188
    Abstract: The present invention relates to producing chemicals and biofuels from wood material, e.g. mixed forest biomass. Specifically, the invention concerns a process for conditioning spent liquor produced by SO2-ethanol-water (SEW) fractionation of wood chips for fermentation to butanol, ethanol and acetone/isopropanol (so called ABE process) by Clostridia bacteria.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: April 21, 2015
    Assignee: API Intellectual Property Holdings, LLC
    Inventors: Adriaan Van Heiningen, Evangelos Sklavounos
  • Patent number: 8993272
    Abstract: The present invention relates to a microorganisms of the genus Corynebacterium producing 5?-inosinic acid, in which the expression of genes encoding purine biosynthesis related enzymes is increased higher than the intrinsic expression, and to a method for producing 5?-inosinic acid, comprising culturing the microorganisms of the genus Corynebacterium with improved 5?-inosinic acid productivity.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: March 31, 2015
    Assignee: CJ Cheiljedang Corporation
    Inventors: Jeong Hwan Kim, Jung Gun Kwon, Tae Min Ahn, Soo Youn Hwang, Min Ji Baek, Na Ra Kwon, Nan Young Yoon, Ju Jeong Kim
  • Patent number: 8980597
    Abstract: Processes are disclosed for the low energy, anaerobic bioconversion of hydrogen and carbon monoxide in a gaseous substrate stream to oxygenated organic compounds such as ethanol by contact with microorganisms in a fermentation system with high conversion efficiency of both hydrogen and carbon monoxide. The processes of this invention use a pre-reactor and a deep, tank reactor in gaseous substrate flow sequence to obtain high conversion of gas substrate without undue risk of carbon monoxide inhibition.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: March 17, 2015
    Assignee: Coskata, Inc.
    Inventors: Robert Hickey, Steven L. Donnellan
  • Patent number: 8980620
    Abstract: The present invention relates to the use of microorganisms (biocatalysts), or catalysts derived from these organisms (enzymes), to improve the quality of crude oil and bitumen as an attractive alternative to current upgrading methods. The invention identifies and characterizes the microorganism species, in particular, N. muscorum (UTEX 2209) and Kocuria rhizophilia (ATCC533), that have the capability to biochemically convert organic acids into chemical species that do not possess corrosive properties.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: March 17, 2015
    Assignee: Her Majesty the Queen in Right of Canada as Represented by the Minister of Natural Resources
    Inventors: Heather D. Dettman, Ryan Lister, Louis D. Heerze
  • Patent number: 8975051
    Abstract: This invention relates to recombinant microorganisms capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, functional activity of the ispA gene is altered to reduce the production of isoprenoid molecules in recombinant cells engineered to produce isoprene or in cells otherwise susceptible to isoprenoid accumulation during fermentation. This decreased ispA gene functional activity enables enhanced synthesis of isoprene in a host microorganism.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: March 10, 2015
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Joseph C. McAuliffe, Rachel E. Muir, Alex T. Nielsen, Caroline M. Peres, Dmitrii V. Vaviline, Derek H. Wells
  • Publication number: 20150050691
    Abstract: The present invention relates to a method for preparing a mutant E. coli strain, capable of simultaneously using glucose and xylose, by genetic engineering and evolutionary adaptation; the mutant E. coli prepared using the same; and a method for producing biofuels, biologically active ingredients, medicinal materials or base chemicals for the chemical industry using the mutant E. coli. Being capable of simultaneously using glucose and xylose, in contrast to wild-type E. coli, the mutant E. coli can be effectively applied to the enzymatic saccharification process of producing biofuels from a biomass.
    Type: Application
    Filed: July 2, 2014
    Publication date: February 19, 2015
    Applicant: UNIST ACADEMY-INDUSTRY RESEARCH CORPORATION
    Inventors: Sung Kuk LEE, Goo Hee KIM, Seong Hun JEONG, Suk Min KIM, Bae Young CHOI
  • Patent number: 8927242
    Abstract: An embodiment is a method of preventing, mitigating or treating Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) that includes administering an effective amount of a medicament comprised of Streptococcus oralis 89a to a human to prevent, mitigate or treat PANDAS.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: January 6, 2015
    Assignee: NuBiome, Inc.
    Inventors: Brian C. Lue, Fredrick C. Westall
  • Patent number: 8927231
    Abstract: Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides, polypeptides, and proteins with the characteristics and location of the corresponding genes on the host cell chromosome, such as that of E. coli, yeast, Bacillus subtilis or other prokaryotes, insect cells, mammalian cells, etc. This platform quantitatively describes and identifies priority deletions, modifications, or inhibitions of certain gene products to increase chromatographic separation efficiency, defined as an increase in column capacity, column selectivity, or both, with emphasis on the former. Moreover, the platform provides a computerized knowledge tool that, given separatome data and a target recombinant peptide, polypeptide, or protein, intuitively suggests strategies leading to efficient product purification.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: January 6, 2015
    Assignees: The Board of Trustees of the University of Arkansas, University of Pittsburgh—Of The Commonwealth System of Higher Education
    Inventors: Ellen M. Brune, Robert R. Beitle, Jr., Mohammad M. Ataai, Patrick R. Bartlow, Ralph L. Henry
  • Patent number: 8927246
    Abstract: A method of increasing the production of extracellular polymeric substances (EPS) in an Acidithiobacillus ferrooxidans culture is disclosed. The method includes inhibiting an enzyme, such as citrate synthase, aconitase, or isocitrate dehydrogenase, in the tricarboxylic acid (TCA) cycle leading to alpha-ketoglutarate.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: January 6, 2015
    Assignees: Universidad de Chile, BioSigma S.A.
    Inventors: Alejandro Eduardo Maass Sepúlved, Pablo Andrés Moreno Cortéz, Marko Antonio Budinich Abarca, Pilar Angélica Parada Valdecantos, Leandro Mauricio Padilla Iglesias, Marlen Nayibe Barreto Roa
  • Patent number: 8926960
    Abstract: The present invention relates to methicillin-resistant Staphylococcus aureus growth inhibition by lactic acid bacterium strains. More specifically it is directed to the use of lactic acid bacterium strains, compositions comprising lactic acid bacterium strains, methods of use and kits thereof to inhibit the growth of methicillin-resistant Staphylococcus aureus. This invention more specifically relates to the inhibitory effect of lactic acid bacterium strains Lactobacillus acidophilus and Lactobacillus caseion methicillin-resistant Staphylococcus aureus.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: January 6, 2015
    Assignee: Bio-K Plus International Inc.
    Inventors: Wanda Smoragiewicz, Mari Bazo, Marcia Ruiz, François-Marie Luquet, Antoni Wysocki
  • Patent number: 8900841
    Abstract: Some products such as solvents, e.g., butanol, are toxic to solvent-producing microorganisms, yet fructose metabolism can facilitate the increase of protective substrates such as triglycerides, which can protect the microorganism from the toxic effect of the product. Methods are provided for producing a product, e.g., a solvent from fructose derived from a cellulosic or lignocellulosic material. Using the methods herein, a fructose solution can be fermented to a solvent more rapidly, and with better yields, than a glucose solution.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: December 2, 2014
    Assignee: Xyleco, Inc.
    Inventors: Marshall Medoff, Thomas Craig Masterman, Michael W. Finn
  • Patent number: 8895060
    Abstract: Methods and apparatus for providing a leak-proof seal for two-piece capsules containing oil-based liquids or other compositions by a two-stage process. The capsule cap and capsule body are combined by a nitrogen purge instant bonding (NPIB) system. An overlay medium is applied to selected portions of the capsule, including near the seam formed by the interconnection of the capsule cap and capsule body to provide a substantially leak-proof seal. The overlay medium is made from materials that make up the capsule cap and capsule body, including gelatin, starch, cellulose or polysaccharides, among others, which are dispersed in a hydro-alcoholic, aqueous or organic solution. The overlay medium includes additives to impart desired qualities to the capsule and include taste-enhancers, taste-maskers, odor-enhancers and odor-maskers. The additives may include color additives, aroma additives and taste additives.
    Type: Grant
    Filed: October 16, 2006
    Date of Patent: November 25, 2014
    Assignee: Vita-Herb Nutriceuticals, Inc.
    Inventor: Bing Baksh
  • Patent number: 8889374
    Abstract: The present invention relates to recombinant factor H and variants and conjugates thereof and methods of their production, as well as uses and methods of treatment involving the materials.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: November 18, 2014
    Assignee: University Court of the University of Edinburgh
    Inventors: Christoph Schmidt, Paul N. Barlow, Anna Richards
  • Publication number: 20140335073
    Abstract: A nutritional composition comprising a combination of non-digestible oligosaccharides and a product obtained by incubating an aqueous substrate by bifidobacteria and optionally a product obtained by incubating an aqueous substrate by S. thermophilus. Said combination reduces bacterial translocation and improves the intestinal barrier function.
    Type: Application
    Filed: March 7, 2014
    Publication date: November 13, 2014
    Applicant: N.V. Nutricia
    Inventors: Jan KNOL, Cornelus Johannes Petrus VAN LlMPT, Francis LE CROIX, Valérie PETAY
  • Patent number: 8883240
    Abstract: A low calcium sensitive (calcium stable) high acyl gellan gum is prepared for enhanced colloidal stability in beverages. The low calcium sensitive high acyl gellan gum has superior suspension performance for colloidal stability compared to other high acyl gellan gums. The low calcium sensitive high acyl gellan gum is prepared by adjusting the pH of a gellan fermentation broth (polymer solution) prior to pasteurization and reducing the pasteurization hold time compared to conventional pH levels and hold times.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: November 11, 2014
    Assignee: CP Kelco U.S., Inc.
    Inventors: C. Ronnie Yuan, Neil Argo Morrison, Ross Clark
  • Patent number: 8871480
    Abstract: The present invention relates to a mutant microorganism with enhanced sugar utilization and methods for preparing the same. The mutant strain is capable of effectively utilizing various sugars including cellobiose and xylose, and can thus be useful in the production of biofuels, physiologically active materials, medicinal materials or industrial chemicals from cellulosic biomass. It also reduces the need for addition of one out of the three enzymes used in the saccharification of lignocellulose. It also eliminates the need for separate reactors to ferment pentose and hexose sugar.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: October 28, 2014
    Assignee: Unist Academy-Industry Research Corporation
    Inventors: Sung Kuk Lee, Vinuselvi Parisutham
  • Patent number: 8871482
    Abstract: Functionalized substrate materials, for example inorganic particles and/or synthetic polymeric particles, are used to enhance bioprocesses such as saccharification and fermentation.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: October 28, 2014
    Assignee: Xyleco, Inc.
    Inventors: Marshall Medoff, Thomas Craig Masterman, Harrison Medoff
  • Patent number: 8871479
    Abstract: The invention relates to applications of the cellulase Cel5H of Saccharophagus degradans and its homologues, functional fragments and/or variants and engineered forms thereof, in the context of recombinant, more particularly solventogenic microorganisms, more particularly C. acetobutylicum. The invention also characterizes a novel domain of the Cel5H cellulase with a putative cellulose-binding module function, and its uses in chimeric proteins for depolymerization of cellulose containing substrates.
    Type: Grant
    Filed: November 26, 2009
    Date of Patent: October 28, 2014
    Assignees: Total Marketing Services, Le Centre National de Recherche Scientifiques (CNRS), L'Institut National des Sciences Appliquees (INSA), Universite d'Aix-Marseille
    Inventors: Henri-Pierre Fierobe, Angélique Chanal-Vial, Anne-Laure Molinier, Chantal Tardif, Luc Dedieu
  • Patent number: 8871266
    Abstract: Probiotic microorganisms are micro encapsulated by dispersing the probiotic microorganism in an aqueous suspension of a film forming protein and a carbohydrate; in an oil in water emulsion of a film forming protein and a carbohydrate and a fat; or in an oil which is subsequently dispersed in a film forming protein and a carbohydrate. The emulsion or suspension may be dried to form a powder. The probiotic may be dispersed in oil and then emulsified with the aqueous suspension and then dried to produce an encapsulated oil be dried to produce a powder. Oil suspended probiotics may be preferred where the probiotic is water sensitive. The preferred protein is casein or whey protein and the carbohydrate may be a resistant starch or a saccharide with a reducing sugar group. Where the probiotic is oxygen sensitive the protein carbohydrate is heated to create Maillard reaction products in the encapsulating film.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: October 28, 2014
    Assignee: Commonwealth Scientific & Industrial Research Organisation
    Inventors: Ross Crittenden, Luz Sanguansri, Mary Ann Augustin
  • Patent number: 8865442
    Abstract: This invention relates to methods for producing isoprene by culturing recombinant cells (e.g., cells engineered to produce isoprene) under reduced oxygen inlet levels.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: October 21, 2014
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Gopal K. Chotani, Brian Kirshner, Jacob Latone, Jeff P. Pucci
  • Patent number: 8859249
    Abstract: A method for producing an iron (III) ion from the acidic solution containing an iodide ion and an iron (II) ion efficiently and stably is provided. The method including performing the following steps (a)-(b), repeatedly and continuously: (a) a step wherein the iron (II) ion in the acidic solution containing the iodide ion and the iron (II) ion is oxidized into iron (III) ion in a reactor using a microbes immobilizing carrier to which iron oxidizing microbes attached; (b) a step wherein sedimentation of the solution obtained in the step (a) is performed in a sedimentation tank to obtain the solution containing the iron (III) ion and concurrently the sediment of the microbes immobilizing carrier to which the iron oxidizing microbes have attached is recovered and then reintroduced into the reactor in the step (a).
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: October 14, 2014
    Assignee: JX Nippon Mining & Metals Corporation
    Inventors: Kenichi Kuwano, Akira Miura
  • Patent number: 8859235
    Abstract: A method for the manufacture of products by biotechnological methods in bacterial cell culture is disclosed as well as products obtained, the use of certain additives to the media used in the manufacture of said products in bacterial cell culture media, and the use of said additives in reducing the detrimental effects of radicals in the manufacture of the products, as well as aspects related to these invention embodiments. The manufacturing process or method comprises adding one or more radical scavenging and/or antioxidative additive preferably selected from the group consisting of sterically hindered nitroxyls, sterically hindered hydroxylamines, sterically hindered hydroxylamine salt compounds, sterically hindered amino compounds and sterically hindered N-hydrocarbyloxyamines, benzofuranone compounds, as obligatory component(s) to the medium used during biosynthesis.
    Type: Grant
    Filed: August 11, 2010
    Date of Patent: October 14, 2014
    Assignee: BASF SE
    Inventors: Franz Kaufmann, Trine Hefsgaard Miller, Johannes Flothmann, Beate Winter, Andreas Hafner
  • Patent number: 8852907
    Abstract: The efficient production of ethanol from low-cost biomass (e.g., corn, sugar beets, sugar cane, switchgrass and/or paper) has become increasingly important in making ethanol competitive with gasoline and decreasing the United States' dependence on foreign oil. For example, to reduce the cost of transporting biomass to ethanol production facilities, mobile systems for producing ethanol from biomass are provided. Also provided are small-scale ethanol production facilities. For example, instead of transporting biomass to the production facility, the facility is transported to the biomass or is located nearby the source of the biomass. The ethanol production facilities or components thereof may be transported via land, water, or air. Production of other products, such as hydrocarbons, natural gas, hydrogen gas, plastics, polymers, and proteins, can also be made by the methods and facilities. Any product described herein can be made in finished form or un-finished form and moved, e.g., to a fixed facility, e.g.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: October 7, 2014
    Assignee: Xyleco, Inc.
    Inventor: Marshall Medoff
  • Patent number: 8852899
    Abstract: Embodiments of the invention relate to the enzymatic conversion of bioderived feedstocks to commercially valuable chemicals. The enzymatic conversions of the embodiments of the invention offer the potential for lower cost routes to these value-added chemicals. Some of the chemicals that are useful include nylon intermediates such as caprolactam, adipic acid, 1,6-hexamethylene diamine; butanediols such as 1,4-butanediol, 1,3-butanediol, and 2,3-butanediol; butanols such as 1-butanol, and 2-butanol; succinic acid, butadiene, isoprene, and 3-hydroxypropanoic acid.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: October 7, 2014
    Assignee: INVISTA North America S.a.r.l.
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes
  • Publication number: 20140295520
    Abstract: This disclosure describes a cell that includes an engineered subcellular compartment that generally includes a proteinaceous shell that includes at least one bacterial microcompartment (BMC) polypeptide. In some embodiments, the engineered subcellular compartment can further include one or more targeted enzymes. We further describe methods of making and using such cells.
    Type: Application
    Filed: October 25, 2012
    Publication date: October 2, 2014
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Claudia Margarete Schmidt-Dannert, Swati Choudhary Saurkar, Maureen Blacker Quin, Mark Anton Held
  • Patent number: 8846082
    Abstract: An encapsulation system is provided comprising nitrogen-purge, instant bonding encapsulation method. Specifically, the encapsulation system comprises a composition, a two-piece capsule comprising a capsule cap and a capsule body; a gas to purge oxygen from the composition within the capsule; and a sealing solution to seal the capsule cap to the capsule body. Associated methods for encapsulating compositions using the encapsulation system are also provided.
    Type: Grant
    Filed: March 21, 2006
    Date of Patent: September 30, 2014
    Assignee: Vita-Herb Nutriceuticals, Inc.
    Inventor: Bing Baksh
  • Patent number: 8841099
    Abstract: The present invention relates to the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the production of pseudaminic acid, legionaminic acid, UDP-2,4-diacetamido-2,4,6-trideoxy-?-L-altropyranose, and UDP-2,4-diacetamido-2,4,6-trideoxy-?-D-glucopyranose. Methods for producing the sugars are also provided.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: September 23, 2014
    Assignees: National Research Council of Canada, University of Ottawa
    Inventors: Christopher N. Boddy, Susan M. Logan, Benjamin R. Lundgren, Ian C. Schoenhofen, Dennis M. Whitfield
  • Patent number: 8835152
    Abstract: Compositions of peptides and surface-active agents are described, as are methods of making and using such compositions. The compositions are capable of affecting metabolic rates in biological systems, and to accelerate nutrient uptake without a concomitant increase in biofilm production.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: September 16, 2014
    Assignee: Advanced Biocatalytics Corporation
    Inventor: Carl W. Podella
  • Publication number: 20140227758
    Abstract: A method for the inerting of vessels used in the digestion of organic waste, the method characterised by the method steps of: (i) Capturing exhaust gas (14) from a chemical conversion means (12); (ii) Directing at least a portion of the captured exhaust gas (14) from step (i) to a vessel (40) used in the digestion of organic waste; and (iii) Purging the vessel (40) using the exhaust gas (14) so as to avoid an explosive mix of gases therein, wherein the exhaust gas (14) contains sufficient oxygen to prevent substantially the production of methane by anaerobic bacteria in the vessel (40).
    Type: Application
    Filed: June 26, 2012
    Publication date: August 14, 2014
    Applicant: ANAECO LIMITED
    Inventors: Barry Antony Tindall, Gareth James Buckland
  • Patent number: 8802079
    Abstract: A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by producing a compound of interest. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: August 12, 2014
    Assignee: Chr. Hansen A/S
    Inventors: Inge Knap, Ane Knarreborg, Thomas Dyrmann Leser, Lund Bente, Mette Dines Cantor, Patrick Derkx
  • Patent number: 8785160
    Abstract: The invention provides methods and pharmaceutical compositions for treating symptoms associated with lactose intolerance and for overall improvement in gastrointestinal health. Described herein are methods and pharmaceutical compositions for improving overall gastrointestinal health or for decreasing symptoms of lactose intolerance by administering to subject in need thereof a pharmaceutical composition comprising a prebiotic, optionally in combination with effective amount of a probiotic microbe or microbes.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: July 22, 2014
    Assignee: Ritter Pharmaceuticals, Inc.
    Inventors: Andrew J. Ritter, Dennis Savaiano, David Barnes, Todd Klaenhammer