Acting On Hydrogen Peroxide As Acceptor (1.11) Patents (Class 435/192)
  • Patent number: 10989699
    Abstract: Methods and systems are disclosed for analyzing and treating a fluid containing a peroxyacid and/or peroxide. A method of analyzing the fluid includes introducing into the fluid a decomposition agent that catalyzes decomposition of the peroxyacid and/or peroxide into decomposition products including oxygen, then directly or indirectly measuring an amount of oxygen produced after introduction of the decomposition agent, and determining an amount of the peroxyacid and/or peroxide present in the fluid. The amount of peroxyacid and/or peroxide in the fluid can also be monitored and controlled by further adjusting the amount of the peroxyacid and/or peroxide in the fluid based on the determined amount thereof. A system for performing the methods includes a decomposition agent infusion device for introducing the decomposition agent into a fluid sample, and a sensor for directly or indirectly measuring an amount of oxygen produced after introduction of the decomposition agent.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: April 27, 2021
    Assignee: CHEMTREAT, INC.
    Inventors: John Richardson, Mark Puchovich, Benjamin Niemaseck, Kevin White, James Wilkins, Robert Bedinger
  • Patent number: 10696954
    Abstract: Described herein are stable hybrid peroxidases capable of oxidizing manganese and high-reduction potential substrates, methods of generating such peroxidases, and method of using the peroxidases in reactions that are less environmentally toxic.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: June 30, 2020
    Assignees: The Regents of the University of California, National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Amanda C. Kohler, Kenneth L. Sale, Blake A. Simmons
  • Patent number: 9951364
    Abstract: The present invention relates to processes for producing fermentation products from starch-containing material, wherein an alpha-amylase and a thermostable endoglucanase is present and/or added during liquefaction. The invention also relates to compositions suitable for use in processes of the invention.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: April 24, 2018
    Assignee: NOVOZYMES A/S
    Inventors: Zhengfang Kang, Christie Strahler, Suzanne Clark, Kristian Bertel Rømer M. Krogh, Lan Tang
  • Patent number: 9683221
    Abstract: The present invention relates to the field of plant breeding and disease resistance in respect of lignin degradation by Macrophomina phaseolina (“M. phaseolina”). Disclosed are isolated polynucleotides encoding the lignin degrading enzymes produced by Macrophomina phaseolina, or the complement of such sequences. Also disclosed are isolated polypeptides encoded by various polynucleotide sequences; a recombinant gene construct comprising a polynucleotide; a transformant and a transgenic fungus comprising the recombinant gene construct, having enhanced production of lignin degrading enzyme. Further disclosed are polypeptides having an oligomerase activity, e.g., enzymes that convert recalcitrant soluble oligomerase to fermentable sugar in saccharification process of biomass.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: June 20, 2017
    Assignee: Bangladesh Jute Research Institute
    Inventors: Masqsudul Alam, Mohammed S. Islam, Mohammed M. Hossen, Mohammed S. Haque, Mohammed M. Alam
  • Patent number: 9610236
    Abstract: The present invention relates to the cosmetic use of queuine, in particular to combat aging of the skin. It also relates to a cosmetic composition comprising queuine as an active ingredient.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: April 4, 2017
    Assignee: AMABIOTICS
    Inventors: Antoine Danchin, Agnieszka Sekowska
  • Publication number: 20150147780
    Abstract: Disclosed herein are embodiments for a novel method of producing an organic compound, including harvesting at least one organic compound from an organism or cell line genetically engineered with a gene for at least one proton-pump protein.
    Type: Application
    Filed: November 24, 2014
    Publication date: May 28, 2015
    Inventors: Eugene Dinescu, Vincent Dinescu
  • Publication number: 20150147330
    Abstract: Described herein is the identification of a panel of high affinity monoclonal antibodies that bind GPC3. The disclosed antibodies recognize native GPC3 on the surface of cancer cells, as well as soluble GPC3. The highest affinity antibody (YP7) was further characterized and shown to be highly sensitive in that it was capable of detecting cancer cells with low expression of GPC3. YP7 also exhibited significant HCC tumor growth inhibition in vivo. Immunotoxins comprising the antibodies disclosed herein fused to PE38 exhibited very high binding affinity for GPC3-expressing cells and significantly inhibited GPC3-expressing cancer cell growth. Thus, the high-affinity monoclonal antibodies disclosed herein can be used for the diagnosis and treatment of GPC3-expressing cancers.
    Type: Application
    Filed: May 31, 2013
    Publication date: May 28, 2015
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Service
    Inventors: Mitchell Ho, Yen T. Phung, Wei Gao, Yifan Zhang
  • Publication number: 20150147783
    Abstract: The present invention relates to an isolated mutant eubacterium comprising at least one mutation resulting in a substitution of at least one amino acid in the beta-subunit of the RNA-polymerase encoded for by the rpoB-gene providing an altered production of a product of interest when said production of a product of interest is compared to the production of the same product in an isogenic wild type strain grown at identical conditions, wherein the substitution of at least one amino acid occurs at any of positions 469, 478, 482, 485, or 487 of SEQ ID NO:2, or at the equivalent positions in any eubacterial RNA-polymerase beta-subunit family member. Another aspect of the invention relates to a process for producing at least one product of interest in a mutant eubacterium and to a use of the mutant eubacterium according to the invention for producing at least one product of interest.
    Type: Application
    Filed: February 9, 2015
    Publication date: May 28, 2015
    Inventors: Steen Troels Joergensen, Jens Toenne Andersen, Niels Banke, Preben Nielsen
  • Publication number: 20150147451
    Abstract: Disclosed is a process for extracting an antioxidant cocktail (containing a number of antioxidative molecules including but not limited to superoxide dismutase (SOD), catalase, glutathione, glutathione peroxidase) from animal sources (i.e., blood or liver) so that it can be used as a food and feed preservative in a non-purified state to prevent rancidity. The antioxidant can also be used in other products such as oils, paint, caulking, plastics, or any other product exposed to oxidation. The disclosed antioxidant cocktail can be used in an unpurified state, yet can still function as a potent antioxidant without having to undergo purification via complex, expensive methods such as chromatography or gel filtration.
    Type: Application
    Filed: July 16, 2013
    Publication date: May 28, 2015
    Inventors: Vladimir Reukov, Alexey Vertegel
  • Publication number: 20150140574
    Abstract: A modified polynucleotide has a different base sequence in at least one codon from a wild-type base sequence encoding a horseradish peroxidase polypeptide. The usage frequency of the modified codon of the polynucleotide corresponds to the codon usage frequencies of three filamentous fungal species in Humicola, Aspergillus, and Trichoderma. The polynucleotide is capable of expressing the polypeptide to be encoded in a filamentous fungus.
    Type: Application
    Filed: May 30, 2013
    Publication date: May 21, 2015
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Fumikazu Yokoyama, Kaoru Okakura, Atsushi Inoue, Koichiro Murashima, Toshiaki Nagasato, Koji Yanai, Akitaka Nakane
  • Publication number: 20150140591
    Abstract: The invention concerns the field of cell culture technology. It concerns RNA having a specific sequence, expression vectors encoding said RNA, production host cell lines comprising said RNA, and methods of producing recombinant biopharmaceutical products using engineered host cell with altered levels of said RNAs, such as small non-coding RNAs, preferably microRNAs (miRNAs). The invention also relates to engineered host cells with altered levels in one or more of said RNAs. Those cell lines have improved secretion and/or growth characteristics in comparison to control cell lines.
    Type: Application
    Filed: June 4, 2013
    Publication date: May 21, 2015
    Inventors: Lore Florin, Hitto Kaufman, Angelika Hausser, Monilola Olayioye, Michaela Strotbek
  • Publication number: 20150139977
    Abstract: The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal ?-1,4-xylosidic linkages or endo-?-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: October 22, 2014
    Publication date: May 21, 2015
    Inventors: David Weiner, David Blum, Alexander Varvak, Shaun Healey, Kristine Chang, Geoff Hazlewood, Thomas Todaro, Grace Desantis, Hwai Chang, Connie Jo Hansen, Scott W. Beaver, Thomas Woodward, Charles Hancock
  • Publication number: 20150140612
    Abstract: The present invention relates to methods for increasing hydrolysis of a pretreated cellulosic material, comprising subjecting the pretreated cellulosic material to a cellulolytic enzyme composition; a polypeptide having cellulolytic enhancing activity; a Peroxidase; and a nonionic surfactant and/or cationic surfactant, at conditions suitable for hydrolyzing the pretreated lignocellulosic material. The invention also relates to processes for producing a fermentation product comprising a hydrolysis step of the invention and a composition suitable for use in a method of the invention.
    Type: Application
    Filed: July 18, 2013
    Publication date: May 21, 2015
    Inventors: Ye Chen, Jiyin Liu, Terry Green, Mark V. Stevens, Hui Xu
  • Publication number: 20150132820
    Abstract: An object is to efficiently produce thermostable catalase at low cost by expressing it as a recombinant protein in large quantity. A recombinant microorganism capable of efficiently expressing thermostable catalase can be provided by obtaining a DNA necessary for efficiently producing it as a recombinant protein, and the thermostable catalase can be efficiently produced at low cost by cultivating the obtained recombinant microorganism. Hydrogen peroxide can be efficiently decomposed at low cost, even at high temperature, by treating a solution containing hydrogen peroxide with the thermostable catalase of the present invention.
    Type: Application
    Filed: January 27, 2015
    Publication date: May 14, 2015
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Kaoru OKAKURA, Fusuke MAZUKA, Takayoshi FUKUSHIMA, Koichiro MURASHIMA
  • Publication number: 20150125926
    Abstract: A tripartite nanodevice comprising a targeting portion, a carrier portion, and at least one molecule to be delivered is provided. In particular, a gold nanoparticle linked to a targeting protein and capable of delivering a stimulant for the treatment of respiratory or disease is described. A method of making and a method of using a device of this nature are also described.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 7, 2015
    Inventors: Harry Goshgarian, Guangzhao Mao, Yanhua Zhang
  • Publication number: 20150125925
    Abstract: The present invention provides consumer products comprising a serine protease variant, more specifically subtilisin variants produced there from. Specifically, the present invention provides consumer products comprising a serine protease variant, more specifically a subtilisin variant having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides methods of making such compositions and methods of treating surfaces, particularly fabric surfaces comprising contacting a surface with an aqueous liquor comprising a serine protease variant, more specifically subtilisin variants and an adjunct material.
    Type: Application
    Filed: November 5, 2013
    Publication date: May 7, 2015
    Applicant: The Procter & Gamble Company
    Inventors: Philip Frank SOUTER, Euan John MAGENNIS, Glenn Steven WARD, Neelam S. AMIN, Katherine AUGUSTYN, Joshua R. BASLER, Luis Gustavo CASCAO-PEREIRA, Katherine D. COLLIER, Edward M. CONCAR, David A. ESTELL, James T. KELLIS, JR., Alexander PISARCHIK, Ayrookaran Joseph POULOSE, Jian YAO
  • Publication number: 20150118155
    Abstract: The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of e.g., IYD, TG, SLC5A5, NIS, TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1, CSTD, DCN and SEPP1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.
    Type: Application
    Filed: June 14, 2012
    Publication date: April 30, 2015
    Applicant: Hill's Pet Nutrition, Inc.
    Inventors: Samer Al-Murrani, Xiangming Gao
  • Publication number: 20150111281
    Abstract: The present compositions and methods relate to the production of polypeptides in submerged culture, and specifically the large-scale production of porphyrin-containing polypeptides, e.g. catalase, by microbial fermentation in the presence of formate.
    Type: Application
    Filed: November 20, 2012
    Publication date: April 23, 2015
    Applicant: DANISCO US INC.
    Inventor: Evan Sims
  • Publication number: 20150072885
    Abstract: A HBS-specific antibody, a LHBS-specific antibody, a WT LHBS-specific antibody, an immunoassay kit comprising the antibodies, and a method of detecting pre-S2 deletion mutant LHBS using the immunoassay kit are disclosed herein. The method comprises incubating a biological sample with a first antibody to captured HBS proteins; detecting the LHBS and WT LHBS bound to the immobilized first antibody, respectively; and calculating the amount of the pre-S2 deletion mutant LHBS protein by subtracting the amount of the WT LHBS protein from that of the LHBS protein. Advantageously, by the method described herein, the amount of the pre-S2 deletion mutant LHBS, a potential high-risk marker for HCC incidence in chronic HBV carriers and recurrence in HCC patients after hepatectomy surgery, in a biological sample may be easily calculated without mutual influence between the WT and pre-S mutant LHBS while reducing the labor-intensive process for cloning each gene product before analysis.
    Type: Application
    Filed: July 16, 2014
    Publication date: March 12, 2015
    Inventors: Wenya Huang, Ih-Jen Su, Yun-Ping Lee
  • Patent number: 8975053
    Abstract: An object is to efficiently produce thermostable catalase at low cost by expressing it as a recombinant protein in large quantity. A recombinant microorganism capable of efficiently expressing thermostable catalase can be provided by obtaining a DNA necessary for efficiently producing it as a recombinant protein, and the thermostable catalase can be efficiently produced at low cost by cultivating the obtained recombinant microorganism. Hydrogen peroxide can be efficiently decomposed at low cost, even at high temperature, by treating a solution containing hydrogen peroxide with the thermostable catalase of the present invention.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: March 10, 2015
    Assignee: Meiji Seika Pharma Co., Ltd.
    Inventors: Kaoru Okakura, Fusuke Mazuka, Takayoshi Fukushima, Koichiro Murashima
  • Publication number: 20150053614
    Abstract: The present invention relates to the use of recombinant heme-containing horseradish peroxidase isoenzyme with improved technological properties such as altered glycosylation, improved catalytic properties or improved stability and different ranges of pH optima and improved surface interactions in the treatment of waste water.
    Type: Application
    Filed: February 14, 2013
    Publication date: February 26, 2015
    Inventors: Martin Kulterer, Victoria Reichel, Volker Ribitsch, Anton Glieder, Florian Krainer
  • Patent number: 8951767
    Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: February 10, 2015
    Assignee: Novozymes A/S
    Inventor: Nikolaj Spodsberg
  • Publication number: 20150037829
    Abstract: An imaging method comprising expressing in cells a Class I heme peroxidase, which optionally is fused with a protein of interest or a cellular localization signal peptide, and contacting the cells with a substrate of the Class I heme peroxidase to allow conversion of the substrate into a product via an oxidation reaction catalyzed by the Class I heme peroxidase, wherein the product releases a signal detectable by a microscope such as an electron microscope. Also disclosed herein are monomeric mutants of a Class I heme peroxidase and mutants of the enzyme that exhibit elevated enzymatic activity as compared to the corresponding wild-type counterpart.
    Type: Application
    Filed: September 14, 2012
    Publication date: February 5, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: Alice Y. Ting, Jeffrey Daniel Martell
  • Publication number: 20150024462
    Abstract: The present disclosure relates to improved expanded bed adsorption processes for isolating proteins from milk sources. In particular embodiments, the present disclosure provides a process for isolating a milk protein, such as lactoferrin, from a milk source comprising establishing an expanded bed adsorption column comprising a particulate matrix, applying a milk source to the matrix, and eluting the lactoferrin from the matrix with an elution buffer comprising about 0.3 to about 2.0 M sodium chloride.
    Type: Application
    Filed: July 16, 2013
    Publication date: January 22, 2015
    Inventors: Dattatreya Banavara, John D. Alvey, Joseph Andrew Peters, Juan M. Gonzalez
  • Publication number: 20140377799
    Abstract: A method for the secretory production of a glycoprotein having a human-type sugar chain, comprising a step of introducing a gene of an enzyme capable of performing a transfer reaction of a galactose residue to a non-reducing terminal acetylglucosamine residue, and a gene of heterologous glycoprotein, to obtain a transformed plant cell, a step of culturing the plant cell, and a step of recovering the culture medium of the plant cell.
    Type: Application
    Filed: April 14, 2014
    Publication date: December 25, 2014
    Applicant: Phyton Holdings, LLC
    Inventors: Kazuhito Fujiyama, Tatsuji Seki, Toshiomi Yoshida
  • Publication number: 20140370563
    Abstract: The present invention is related to compositions and methods for enhanced synthesis of hydrocarbons, particularly, but not limited to, alkanes. The invention, in one embodiment, utilizes the co-expression of a hydrogen peroxide metabolizing enzyme in the presence of an aldehyde decarbonylase enzyme to relieve hydrogen peroxide inhibition of the aldehyde decarbonylase enzyme by hydrogen peroxide. In a preferred embodiment a catalase-aldehyde decarbonylase expression construct and fusion peptide is used. The present invention also relates to microorganisms engineered to express said enzymes and to produce hydrocarbon molecules.
    Type: Application
    Filed: August 24, 2012
    Publication date: December 18, 2014
    Applicant: BROOKHAVEN SCIENCE ASSOCIATES, LLC
    Inventors: John Shanklin, Carl Andre
  • Publication number: 20140363837
    Abstract: The present invention relates to recombinant heme-containing horseradish peroxidase isoenzymes with improved properties. In particular, the present invention relates to a plant enzyme kit comprising recombinant peroxidase isoenzymes, preferably horseradish peroxidase isoenzymes.
    Type: Application
    Filed: October 19, 2012
    Publication date: December 11, 2014
    Applicant: Technische Universitaet Graz (Geaz University of Technology
    Inventors: Florian Krainer, Laura Naeaetsaari, Anton Glieder, Martin Kulterer, Victoria Reichel
  • Publication number: 20140349338
    Abstract: The present invention relates to novel bacteria and the uses thereof. The invention particularly relates to bacteria having a metabolic pathway ratio between Pentose phosphate and glycolysis greater than 0.5, and their uses in the chemical, pharmaceutical or agro-chemical industries, e.g., for producing compounds of industrial interest.
    Type: Application
    Filed: December 21, 2012
    Publication date: November 27, 2014
    Applicant: DEINOVE
    Inventors: Jean-Paul Leonetti, Juha-Pekka Pitkanen, Paula Jouhten
  • Publication number: 20140335572
    Abstract: Provided are isolated polypeptides having catalase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: December 19, 2012
    Publication date: November 13, 2014
    Inventors: Ye Liu, Junxin Duan, Yu Zhang, Lan Tang
  • Publication number: 20140335570
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: Novozymes Inc.
    Inventor: Nikolaj Spodsberg
  • Patent number: 8883442
    Abstract: There are disclosed a culture media and culture supplements for cultivating microorganisms, including Listeria spp and methods for culturing microorganisms including Listeria spp. There are also disclosed methods for detecting the presence of microorganisms including Listeria spp in samples.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: November 11, 2014
    Assignee: Foodchek Systems, Inc.
    Inventors: Gabriela Martinez, David Claveau, Lila Maduro
  • Patent number: 8877477
    Abstract: The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins. The present invention also relates to crosslinked hydroxylic polymer particles functionalized with temperature-responsive copolymer, and to methods of preparing such particles.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: November 4, 2014
    Assignees: Commonwealth Scientific and Industrial Organisation, Monash University
    Inventors: Brad William Woonton, Milton Thomas William Hearn, Pankaj Maharjan, Kirthi De Silva, William Roy Jackson
  • Publication number: 20140322770
    Abstract: The present invention relates to isolated polypeptides having peroxygenaseactivity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: November 28, 2012
    Publication date: October 30, 2014
    Inventors: Sara Landvik, Lars Henrik Oestergaard, Lisbeth Kalum
  • Publication number: 20140322768
    Abstract: The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: November 28, 2012
    Publication date: October 30, 2014
    Inventors: Sara Landvik, Lars Henrik Oestergaard, Lisbeth Kalum
  • Publication number: 20140308701
    Abstract: The present invention relates to recombinant filamentous fungal host cells producing cellulolytic enzyme compositions and methods of producing and using the compositions.
    Type: Application
    Filed: August 23, 2012
    Publication date: October 16, 2014
    Inventors: Jeffrey Shasky, Amanda Fischer, Suchindra Maiyuran
  • Patent number: 8859221
    Abstract: An object to be attained by the present invention is to provide a method for conveniently, rapidly, and specifically measuring HDL-C in a specimen by use of inexpensive materials, and to provide a reagent kit for HDL-C detection and a dry analytical element for HDL-C detection. The present invention provides a method for measuring high density lipoprotein cholesterol (HDL-C) in a body fluid test sample, wherein cholesterol esterase derived from Schizophyllum commune or Pseudomonas sp. and cholesterol oxidase derived from Pseudomonas sp. are used to generate hydrogen peroxide from HDL-C, and thereby HDL-C is selectively measured.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: October 14, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Yoshihiko Abe, Nobuhito Masuda, Hiroko Inomata
  • Publication number: 20140302567
    Abstract: Embodiments of the present disclosure include methods of treating a biomass, in particular lignocellulosic biomass (e.g., switch grass, sweet sorghum, miscanthus, pine wood, corn stover, and the like), under appropriate conditions to effectively reduce and/or reform the lignin contents in lignocellulosic biomass without significantly reducing its sugar contents.
    Type: Application
    Filed: October 11, 2012
    Publication date: October 9, 2014
    Applicant: THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC
    Inventors: Qingguo Huang, Sudeep S. Sidhu
  • Publication number: 20140302583
    Abstract: DNA constructs as well as methods for the production of unicellular organisms capable of producing hydrogen peroxide resistance proteins are disclosed. DNA constructs as well as methods for integration of the DNA constructs into the genomes of unicellular organisms for the expression of hydrogen peroxide production proteins are also disclosed. In addition, DNA constructs as well as methods for integration of the DNA constructs into the genomes of unicellular organisms for the expression of hydrogen peroxide resistance and hydrogen peroxide production proteins are disclosed.
    Type: Application
    Filed: October 4, 2012
    Publication date: October 9, 2014
    Inventors: Stephen K. Herbert, Levi G. Lowder
  • Publication number: 20140295493
    Abstract: The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: April 1, 2014
    Publication date: October 2, 2014
    Inventors: Hiroaki Udagawa, Christian Isak Jorgensen
  • Publication number: 20140249094
    Abstract: An object of the present invention is to provide a safety sensation-improving agent that can improve dulled peripheral sensations through daily ingestion or application to the skin. Another object of the present invention is to provide a sensation-improving food, beverage, feed, or cosmetics that can improve dulled peripheral sensations through oral ingestion or application to the skin. A sensation-improving agent containing a milk-derived protein and/or a hydrolysate therefrom as an active ingredient is provided. The milk-derived protein and/or the hydrolysate therefrom can be orally ingested or applied direct to the skin to improve dulled sensations, particularly peripheral sensations, and be formed into a sensation-improving food, beverage, feed, or cosmetics.
    Type: Application
    Filed: October 2, 2012
    Publication date: September 4, 2014
    Inventors: Ken Katoh, Hiroshi Ueno, Yuko Ono, Noriko Ueda, Toshiya Kobayashi, Takahiro Moriya, Yutaro Obata
  • Publication number: 20140248674
    Abstract: The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: August 10, 2012
    Publication date: September 4, 2014
    Applicant: Novozymes A/S
    Inventors: Sara Landvik, Lars H. Oestergaard, Lisbeth Kalum
  • Publication number: 20140242036
    Abstract: The instant invention refers to a novel process for potentiating the production of substances with antifungal activity obtained from Ganoderma lucidum, using a technological device for the differential, qualitative and quantitative expression of proteins and other bioactive molecules, selected from the group consisting of polysaccharides, triterpenoids, fatty acids and ganoderic acids. The compositions containing said substances showed antifungal activity and mycelium growth and fungi ascospore germination inhibiting activity, amongst them Mycosphaerella fijiensis, primary pathogenic agent causing black Sigatoka disease in banana and plantain crop fields.
    Type: Application
    Filed: June 18, 2013
    Publication date: August 28, 2014
    Inventors: JOHN JAIRO MIRA CASTILLO, PAOLA ANDREA ZAPATA OCAMPO, LUCíA ATEHORTÚA GARCÉS, LIUDA JOHANA SEPÚLVEDA ARANGO, DIEGO FERNANDO ROJAS VAHOS
  • Patent number: 8815234
    Abstract: A method of treatment of a human or animal body surface infection, particularly a fungal infection, comprises applying an aqueous liquid to the infected body surface, e.g. nail region, followed by applying a dressing comprising a source of hydrogen peroxide. Also provided is a combination of the liquid and dressing for use in the method.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: August 26, 2014
    Assignee: Insense Limited
    Inventors: Paul Davis, Andrew Austin
  • Publication number: 20140234918
    Abstract: The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: August 10, 2012
    Publication date: August 21, 2014
    Applicant: Novozymes A/S
    Inventors: Sara Landvik, Lars Henrik Oestergaard, Lisbeth Kalum
  • Publication number: 20140212366
    Abstract: Methods of producing lignin peroxidase are provided. Also provided are methods and cosmetic compositions suitable for skin and hair lightening as well as kits and an article-of manufacturing including active ingredients for skin and hair lightening.
    Type: Application
    Filed: April 6, 2014
    Publication date: July 31, 2014
    Applicant: R.B.T (Rakuto Bio Technologies) Ltd.
    Inventors: Paula BELINKY, Haim Lasser, Carlos Dosoretz
  • Publication number: 20140212931
    Abstract: The present invention concerns iodoperoxidases from Zobellia galactanivorans, isolated nucleic acids encoding same, as well as methods for preparing these enzymes. Moreover, the invention is also directed to the use of such iodoperoxidases in a wide range of industrial, pharmaceutical, medical, cosmetics, and ecological applications, as well as in the food industry.
    Type: Application
    Filed: July 5, 2012
    Publication date: July 31, 2014
    Applicants: Universite Pierre et Marie Curie (Paris 6), Centre National de la Recherche Scientifique (CNRS)
    Inventors: Catherine Leblanc, Ludovic Delage, Gurvan Michel, Etienne Rebuffet, Mirjam Czjzek, Philippe Potin
  • Publication number: 20140206013
    Abstract: An imaging method utilizing a split peroxidase is described herein. Imaging methods involve contacting a cell with a split peroxidase and a substrate thereof to allow conversion of a substrate into a product via an enzymatic reaction catalyzed by the reconstitute split peroxidase. Also disclosed herein are split peroxidases, related products and kits.
    Type: Application
    Filed: January 16, 2014
    Publication date: July 24, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Alice Y. Ting, Jeffrey Daniel Martell
  • Publication number: 20140186870
    Abstract: The application discloses methods, materials, and compositions for the labeling of molecules, for example, proteins, in living cells or in subcellular compartments of living cells. In particular, the application relates to proteomic analysis methods; materials and compositions and means based on direct tagging of unknown proteins with tagging enzymes (such as biotin ligase or a peroxidase) within the vicinity of a tagging substrate (such as a tyramide) within living cells, with optional targeting to specific subcellular locations by expression of genetic constructs.
    Type: Application
    Filed: June 15, 2012
    Publication date: July 3, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Alice Y. Ting, Jeffrey Daniel Martell, Hyun-Woo Rhee, Peng Zou
  • Publication number: 20140178933
    Abstract: An expression vector which is capable of overexpressing a protein of interest in a host cell, a host cell comprising the expression vector, and a method of producing a protein of interest are provided.
    Type: Application
    Filed: April 30, 2012
    Publication date: June 26, 2014
    Applicants: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY, Samsung Electronics Co., Ltd.
    Inventors: Hyun Min Koo, Byung Jo Yu, Ki Sung Lee, Jae Chan Park, Dae Hyuk Kweon, Sung Minm Park
  • Publication number: 20140170715
    Abstract: The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: August 10, 2012
    Publication date: June 19, 2014
    Inventors: Sara Landvik, Lars Henrik Oestergaard, Lisbeth Kalum