Acting On Beta-1, 4 Link Between N-acetylmuramic Acid And 2-acetylamino 2 Deoxy-d-glucose (e.g., Lysozyme, Etc.) Patents (Class 435/206)
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Patent number: 11459553Abstract: The present invention relates to a strain for producing chitinase and application thereof. The class of the strain is named Streptomyces diastaticus CS1801 and the preservation number thereof is CCTCC NO: M2018263. The Streptomyces diastaticus CS1801 of the present invention is derived from naturally fermented prawn paste. By fermentation of prawns, the enzyme activity of the chitosan is as high as 57.3 U/L and the content of chitooligosaccharides is 0.58 mol/L. The present invention provides a new method for producing chitooligosaccharides and has a good application prospect.Type: GrantFiled: October 31, 2019Date of Patent: October 4, 2022Assignee: CHANGSHU INSTITUTE OF TECHNOLOGYInventors: Limei Wang, Tiantian Xu, Bin Qi
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Patent number: 10779555Abstract: The present invention discloses a method for efficiently and mildly reducing ovalbumin allergenicity. The present invention promotes the exposure of the ovalbumin allergenic site to the molecular surface by repeated freezing and thawing pretreatment, and combines transglycosylase and trypsinase for synergistic treatment to reduce the ovalbumin sugar chain and epitope to achieve the purpose of significantly reducing the allergenicity of ovalbumin and egg foods. Compared with other traditional methods such as high temperature and high pressure and other physical means to reduce egg allergenicity, the method significantly improves the specificity and effectiveness of egg desensitization, and minimizes the damage to the nutrition and quality of egg proteins, and is an efficient and mild egg desensitization method. The method has the prospects of being applied to the industrial development of low-allergenicity egg products.Type: GrantFiled: January 24, 2018Date of Patent: September 22, 2020Assignee: NORTHWEST A&F UNIVERSITYInventors: Xiang Duan, Xuebo Liu, Yinying Tan, Ying Lan, Yutang Wang, Zhigang Liu, Chunxia Xiao, Lin Chen
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Patent number: 10570438Abstract: The invention relates to a colorimetric method for detecting bacterial or fungal pathogens by detecting peptidoglycan or (1-3)-?-D-glucan in a sample.Type: GrantFiled: January 26, 2018Date of Patent: February 25, 2020Assignee: Immunetics, Inc.Inventors: Neil X. Krueger, Andrew Han, Andrew E. Levin, Victor Kovalenko
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Patent number: 10240541Abstract: The presently disclosed subject matter relates to an apparatus which enables a use to easily and safely disable a vehicular variable cylinder management technology system, while enabling restoration of the VCM/ECO mode under certain vehicle-related conditions or driving conditions. The presently disclosed apparatus comprises a potentiometer capable of modifying the voltage input received by the vehicle sensors.Type: GrantFiled: January 11, 2018Date of Patent: March 26, 2019Inventor: Brock Matthew Eastman
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Patent number: 9273300Abstract: According to certain embodiments of the present invention, methods for modulating the production of sialic acid in a system are provided, which comprise providing the system with a wild-type GNE-encoding nucleic acid sequence. According to such embodiments, the system may comprise a cell, muscular tissue, or other desirable targets. Similarly, the present invention encompasses methods for producing wild-type GNE in a system that comprises a mutated endogenous GNE-encoding sequence. In other words, the present invention includes providing, for example, a cell or muscular tissue that harbors a mutated (defective) GNE-encoding sequence with a functional wild-type GNE encoding sequence.Type: GrantFiled: February 7, 2008Date of Patent: March 1, 2016Assignee: STRIKE BIO, INCInventors: Phillip Maples, Chris Jay, John J. Nemunaitis
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Patent number: 9132086Abstract: A composition, system and method for modifying an olfactory response to an odorant is disclosed. In some embodiments, the composition includes crystalline metal nanoparticles dispersed in an aqueous medium. The composition is applied to olfactory tissues using a suitable applicator or dispenser. The metal nanoparticles are believed to interact with a G-protein coupled to receptor located in the cilia to moderate (enhance or reduce) sensitivity or ability to smell particular odorants. In accordance with an embodiment of the invention, the composition includes one or more odorants.Type: GrantFiled: September 17, 2013Date of Patent: September 15, 2015Assignee: AUBURN UNIVERSITYInventors: Vitaly J. Vodyanoy, Nilmini Viswaprakash, Ludmila Petrovna Globa, Edward E. Morrison
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Patent number: 9050332Abstract: The present invention relates to a composition comprising at least one biologically active protease and at least one biologically active glycosidase wherein the proteases and the glycosidases are present in an activity ratio of from 1,000,000:1 to 1:1,000,000 and wherein the composition has a total enzyme activity of at least 2 U/ml. Furthermore, the present invention relates to a process of producing such enzyme comprising composition and to processes of removing caries. Moreover, the invention relates to the use of one or more enzyme comprising compositions for producing a treatment agent for removing caries.Type: GrantFiled: May 16, 2008Date of Patent: June 9, 2015Assignee: 3M Innovative Properties CompanyInventors: Ingo Häberlein, Rainer Guggenberger, Wolfgang Weinmann, Oliver Kappler
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Publication number: 20150132749Abstract: The invention generally relates to methods and kits for isolating nucleic acids from an organism. In certain embodiments, methods of the invention involve contacting a plurality of lytic enzymes to an organism, thereby lysing a cell wall of the organism to release the nucleic acid, and introducing at least one agent to separate the nucleic acid from the lysed cells, thereby isolating the nucleic acid.Type: ApplicationFiled: January 12, 2015Publication date: May 14, 2015Inventor: John Kevin Henkhaus
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Publication number: 20150023945Abstract: The present invention is directed to lysozyme variants and nucleotide sequences encoding same. The lysozyme variants have antimicrobial and/or lysozyme activity and comprise an alteration of an amino acid sequence at one or more positions. The present invention is also directed to methods for producing and of using the Opisthocomus hoazin lysozyme and the lysozyme variants of the present invention as antimicrobial agents.Type: ApplicationFiled: September 29, 2014Publication date: January 22, 2015Inventors: Mikkel Klausen, Marie Allesen Holm, Leonardo De Maria, Michael Skjoet
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Publication number: 20150017702Abstract: A crystallization substrate of the present invention includes a noble metal vapor-deposited film having an absorbance in a 500 to 1,000 nm wavelength range and formed in all or part of one surface of the substrate. The noble metal vapor-deposited film has an average thickness of 0.1 to 60 nm. The noble metal vapor-deposited film is a continuous film with a pit formed by vapor deposition in part of the film and surrounded by the continuous film.Type: ApplicationFiled: January 25, 2013Publication date: January 15, 2015Inventor: Tetsuo Okutsu
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Publication number: 20140380527Abstract: The present invention relates to isolated polypeptides having lysozyme activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 23, 2012Publication date: December 25, 2014Inventor: Kirk Matthew Schnorr
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Patent number: 8906365Abstract: The application relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of Gram-negative bacteria and a peptide stretch fused to the enzyme at the N- or C-terminus, as well as pharmaceutical compositions thereof. Moreover, it relates to nucleic acid molecules encoding such a fusion protein, vectors carrying the nucleic acid molecules and host cells transformed with either the nucleic acid molecules or the vectors. In addition, it relates to such a fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means or as cosmetic substance. The application also relates to the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries.Type: GrantFiled: June 28, 2010Date of Patent: December 9, 2014Assignees: Lysando AG, Katholieke Universiteit Leuven, K.U. Leuven R&DInventors: Rob Lavigne, Stefan Miller, Yves Briers, Guido Volckaert, Maarten Walmagh
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Patent number: 8865637Abstract: The present invention relates to variant lysozymes. The present invention also relates to polynucleotides encoding the variant lysozymes and to nucleic acid constructs, vectors, and host cells comprising the polynucleotide.Type: GrantFiled: February 25, 2011Date of Patent: October 21, 2014Assignee: Novozymes AlsInventor: Leonardo De Maria
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Publication number: 20140273158Abstract: Disclosed are composite materials and methods of using them for chromatography. The composite materials retain their performance characteristics, such as binding capacity, flux, or percent recovery, under caustic conditions (e.g., 1 M NaOH for 24 h). In certain embodiments, the composite materials or membranes comprise a support member, comprising a plurality of pores extending through the support member; and a cross-linked gel. Importantly, the cross-linker and the monomer do not contain backbone ester linkages. The composite materials may be used in the separation or purification of a biological molecule or biological ion.Type: ApplicationFiled: March 7, 2014Publication date: September 18, 2014Applicant: Natrix Separations Inc.Inventor: Amro Ragheb
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Publication number: 20140162341Abstract: Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a family C G-protein coupled receptor (GPCR), wherein the first portion comprises the TM1, TM2 and TM3, regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, wherein the second portion comprises the TM4, TM5 TM6 and TM7 regions of the GPCR.Type: ApplicationFiled: May 16, 2013Publication date: June 12, 2014Applicant: ConfometRx, Inc.Inventor: ConfometRx, Inc.
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Publication number: 20140161788Abstract: The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide.Type: ApplicationFiled: November 27, 2013Publication date: June 12, 2014Applicant: BioMarin Pharmaceutical Inc.Inventors: Mika Aoyagi-Scharber, Teresa Margaret Christianson, Melita Dvorak-Ewell, Daniel J. Wendt, Shinong Long, Jonathan LeBowitz, Daniel Solomon Gold
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Patent number: 8748150Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.Type: GrantFiled: May 21, 2012Date of Patent: June 10, 2014Assignee: GangaGen, Inc.Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
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Patent number: 8741619Abstract: A method for purifying protein aqueous is provided. A protein aqueous is first provided. An absorption material is mixed into the protein aqueous to form a first mixture. The first mixture is separated into a solid-liquid two phases solution by a first separation process. A buffer solution is added into the solid phase from the solid-liquid two phases solution which has a target protein therein to form a second mixture. Then, a second separation process is performed to separate the second mixture to obtain a purified protein aqueous.Type: GrantFiled: February 1, 2013Date of Patent: June 3, 2014Assignee: Chung Yuan Christian UniversityInventors: Tsung-Yen Tsai, Shih-Sin Huang, Chao-Chen Hsu
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Publication number: 20140079671Abstract: The present invention is directed to the field of phage therapy for the treatment and control of bacterial infections. In particular, the present invention is directed to the novel bacteriophage F387/08, F391/08, F394/08, F488/08, F510/08, F44/10, and F125/10, isolated polypeptides thereof, compositions comprising one or more of the novel bacteriophage and/or isolated polypeptides, as well as to methods for the treatment and prevention of bacterial infections using same, either alone or in combination with other antibacterial therapies, e.g., antibiotics and/or other phage therapies.Type: ApplicationFiled: September 19, 2011Publication date: March 20, 2014Applicants: TECHNOPHAGE, INVESTIGAÇÃO E DESENVOLVIMENTO EM BIOTECNOLOGIA, SA, TECNIFAR-INDÚSTRIA TÉCNICA FARMACÊUTICA, S.A.Inventors: Miguel Ângelo Da Costa Garcia, Carlos Jorge Sousa De São José, Clara Isabel Rodrigues Leandro, Filipa Maria Rodrigues Pardal Dias Antunes Marçal Da Silva, Ana Raquel Martins Barbosa
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Patent number: 8597884Abstract: A full process control for use with a molecular assay and a method of determine the efficacy of the molecular assay. A full process control can include a fixed cell, and specifically can include a fixed vegetative cell. A method of determining the efficacy of a molecular assay can include providing an internal control, mixing the internal control with a sample, lysing the internal control and the sample, and detecting the lysis product. The full process control and/or the internal control can be Bacillus subtilis cells.Type: GrantFiled: March 9, 2012Date of Patent: December 3, 2013Assignee: Becton, Dickinson and CompanyInventors: Benoit Dore, Christian Menard, Tobin Hellyer
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Patent number: 8586021Abstract: The present invention provides a mimetic egg comprising ?-glucosidase, a salt thereof, a biological fragment thereof or a ?-glucosidase-related peptide as an egg recognition pheromone in its base material mimicking an egg of a insect pests, particularly a termite, a method for exterminating and controlling insect pests, and a tool for a biological study using the same.Type: GrantFiled: June 1, 2009Date of Patent: November 19, 2013Assignee: National University Corporation Okayama UniversityInventor: Kenji Matsuura
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Patent number: 8574883Abstract: A method of co-extracting multiple proteins from chicken egg white is provided. Precipitate proteins step-by-step with polyethylene glycol, then separate the proteins via Q Sepharose Fast Flow anion-exchange chromatography. The method of co-extracting multiple proteins from chicken egg white is capable of obtaining five proteins simultaneously in one extraction process, and the protein products have high purity and high recovery ratio. And the method can be carried out only requiring common-used chromatographic filler, greatly reduces production cost, and provides favorable factors for large-scale industrial production of extracting protein from egg white.Type: GrantFiled: January 18, 2013Date of Patent: November 5, 2013Assignee: Huazhong Agricultural UniversityInventors: Meihu Ma, Fang Geng, Qun Huang
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Publication number: 20130266554Abstract: The present invention is directed to lysozyme variants and nucleotide sequences encoding same. The lysozyme variants have antimicrobial and/or lysozyme activity and comprise an alteration of an amino acid sequence at one or more positions. The present invention is also directed to methods for producing and of using the Opisthocomus hoazin lysozyme and the lysozyme variants of the present invention as antimicrobial agents.Type: ApplicationFiled: September 15, 2011Publication date: October 10, 2013Applicant: NOVOZYMES A/SInventors: Mikkel Klausen, Marie Allesen Holm, Leonardo De Maria, Michael Skjoet
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Publication number: 20130260437Abstract: A method of co-extracting multiple proteins from chicken egg white is provided. Precipitate proteins step-by-step with polyethylene glycol, then separate the proteins via Q Sepharose Fast Flow anion-exchange chromatography. The method of co-extracting multiple proteins from chicken egg white is capable of obtaining five proteins simultaneously in one extraction process, and the protein products have high purity and high recovery ratio. And the method can be carried out only requiring common-used chromatographic filler, greatly reduces production cost, and provides favorable factors for large-scale industrial production of extracting protein from egg white.Type: ApplicationFiled: January 18, 2013Publication date: October 3, 2013Applicant: Huazhong Agriculture UniversityInventors: Meihu Ma, Fang Geng, Qun Huang
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Patent number: 8512710Abstract: The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.Type: GrantFiled: August 23, 2010Date of Patent: August 20, 2013Assignee: Ansun Biopharma, Inc.Inventors: Fang Fang, Michael Malakhov
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Publication number: 20130210117Abstract: A polypeptide in crystalline form comprises a G-protein coupled receptor (GPCR) with an IC3 loop substituted by an amino acid residue sequence of lysozyme.Type: ApplicationFiled: March 28, 2013Publication date: August 15, 2013Applicant: The Scripps Research InstituteInventor: The Scripps Research Institute
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Publication number: 20130058912Abstract: The present invention is a genetically engineered version of a lysozyme protein wherein the engineered enzyme exhibits enhanced antimicrobial activity, relative to the wild type enzyme, as a result of a reduced overall electrostatic charge. Such an enzyme is an attractive therapeutic candidate for treating microbial or viral infections, particularly in cases where the infection results in an accumulation of polyanion inhibitors at the site of infection. Respiratory tract infections are one example of an infection where such an enzyme might be a particularly useful drug.Type: ApplicationFiled: January 19, 2010Publication date: March 7, 2013Inventors: Karl Griswold, Thomas Carr Scanlon
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Publication number: 20120288490Abstract: The present invention relates to variant lysozymes. The present invention also relates to polynucleotides encoding the variant lysozymes and to nucleic acid constructs, vectors, and host cells comprising the polynucleotide.Type: ApplicationFiled: February 25, 2011Publication date: November 15, 2012Applicant: NOVOZYMES A/SInventor: Leonardo De Maria
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Patent number: 8202516Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.Type: GrantFiled: May 4, 2007Date of Patent: June 19, 2012Assignee: GangaGen, Inc.Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
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Publication number: 20120141590Abstract: Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.Type: ApplicationFiled: September 30, 2011Publication date: June 7, 2012Inventors: Michael Malakhov, Fang Fang
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Publication number: 20120135439Abstract: A method for producing an accumulated product of a nano-substance that enables the accumulated product of the nano-substance to be produced at low cost, by a simple process that requires few conditions to be controlled and requires minimal energy, and with good reproducibility. Specifically, a method for producing an accumulated product of a nano-substance, the method including crystallizing a protein in a state where the protein and the nano-substance co-exist within a solvent, thereby accumulating the nano-substance within pores of the protein crystals to obtain the accumulated product of the nano-substance.Type: ApplicationFiled: July 30, 2010Publication date: May 31, 2012Applicants: THE UNIVERSITY OF TOKYO, GENESIS RESEARCH INSTITUTE, INCORPORATEDInventors: Yoshihiro Takeda, Fumitaka Mafune, Tamotsu Kondow, Kazuko Kondow
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Publication number: 20120135442Abstract: The invention relates to a method comprising: providing a molecularly imprinted polymer imprinted with a first peptide or protein; exposing said molecularly imprinted polymer to a supersaturated solution of a second peptide or protein; and forming a nucleus of and/or growing a crystal of said second peptide or protein on said molecularly imprinted polymer.Type: ApplicationFiled: May 12, 2010Publication date: May 31, 2012Applicant: UNIVERSITY OF SURREYInventors: Subrayal Medapati Venkt Reddy, Naomi Esther Chayen
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Publication number: 20120052552Abstract: The present invention relates to methods for the separation of various components from eggs. More particularly, the present invention relates to methods for the separation of proteins and lipids from eggs, including technical eggs (inedible) or edible eggs, yolks or whites, which comprises cross-linking the lipids of eggs with a cross-linking reagent. In an embodiment, the method includes separating the proteins from the cross-linked lipids. In an embodiment, the method includes the separation of various components associated with the cross-linked lipids. The methods disclosed herein allow for the isolation of multiple different components from the egg in an efficient, cost-effective manner without compromising the recovery process of the components or their subsequent utility in various applications or compositions. The compositions and isolated components obtained by the methods of the invention can be used in pharmaceutical, medical, nutritional, cosmetic or health applications.Type: ApplicationFiled: November 4, 2011Publication date: March 1, 2012Applicant: BIOVA, L.L.C.Inventors: Ronald E. Strohbehn, Jesse I. Figgins
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Patent number: 8084036Abstract: The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of the target cell by a pathogen, such as a virus. Preferred target cells are epithelial cells. The invention provides compositions and methods for preventing viral diseases, such as influenza, using compounds having anchoring domains that can bind target cells linked to enzymatic activities that can act extracellularly to interfere with viral infection of target cells. The invention also provides compositions and methods for preventing viral diseases such as influenza using compounds having anchoring domains that can bind target cells linked to protease inhibitors that can act extracellularly to interfere with viral infection of target cells.Type: GrantFiled: November 21, 2003Date of Patent: December 27, 2011Assignee: NexBio, Inc.Inventors: Mang Yu, Fang Fang, Michael Malakhov
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Publication number: 20110311499Abstract: The present invention provides reagents and methods for inhibiting bacterial infection and abnormal cell growth, as well as for selection cloning of nucleic acid inserts.Type: ApplicationFiled: July 12, 2011Publication date: December 22, 2011Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATIONInventors: JOSEPH MOUGOUS, ALISTAIR BRIAN RUSSELL, MICHELE LEROUX
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Publication number: 20110207659Abstract: Oligosaccharides and oligosaccharides linked to backbones such as proteins, methods for making such oligosaccharides and methods for using them to treat and/or prevent various disorders are described.Type: ApplicationFiled: February 22, 2011Publication date: August 25, 2011Applicants: Children's Hospital Medical Center, University of Massachusetts, Instituto Nacional de Ciencias Medicas Y NutricionInventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
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Publication number: 20110189756Abstract: Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR.Type: ApplicationFiled: February 16, 2011Publication date: August 4, 2011Inventors: Brian Kobilka, Daniel Rosenbaum
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Publication number: 20110177521Abstract: The invention generally relates to methods and kits for isolating nucleic acids from an organism. In certain embodiments, methods of the invention involve contacting a plurality of lytic enzymes to an organism, thereby lysing a cell wall of the organism to release the nucleic acid, and introducing at least one agent to separate the nucleic acid from the lysed cells, thereby isolating the nucleic acid.Type: ApplicationFiled: January 19, 2010Publication date: July 21, 2011Applicant: OpGen, Inc.Inventor: John Kevin Henkhaus
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Publication number: 20110117626Abstract: Described herein are composite materials and methods of using them for hydrophobic interaction chromatography (HIC). In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a macroporous cross-linked gel, comprising a plurality of macropores, and a plurality of pendant hydrophobic moieties. In certain embodiments, the composite materials may be used in the separation or purification of a biological molecule or biological ion.Type: ApplicationFiled: November 15, 2010Publication date: May 19, 2011Inventors: Elena N. Komkova, Alicja M. Mika, Marianne Pankratz
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Publication number: 20110104103Abstract: The present invention relates to a cell-targeting complex comprising a targeting moiety and a deliverable compound, wherein said targeting moiety and said deliverable compound are joined by means of a (transition) metal ion complex having at least a first reactive moiety for forming a coordination bond with a reactive site of said targeting moiety and having at least a second reactive moiety for forming a coordination bond with a reactive site of said deliverable compound, and wherein said deliverable compound is a therapeutic compound.Type: ApplicationFiled: July 20, 2006Publication date: May 5, 2011Applicant: KREATECH BIOTECHNOLOGY B.V.Inventors: Robert Jochem Heetebrij, Robbert Jan Kok, Eduard Gerhard Talman, Klaas Poelstra, Grietje Molema
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Publication number: 20110033439Abstract: Targeted antimicrobials are described and related, compositions, methods and systems.Type: ApplicationFiled: August 6, 2010Publication date: February 10, 2011Inventors: PAUL L. JACKSON, BRIAN E. SOUZA, FELIZA A. BOURGUET, MATTHEW A. COLEMAN
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Patent number: 7838275Abstract: A fragment of lysozyme which contains a minimum nine amino acid sequence with antiviral, anti-tumor and bactericidal activities but lacking muramidase activity is provided. The invention also relates to pharmaceutical compositions containing this fragment and methods for treating HIV infection or for inhibiting tumor growth using this fragment as an active ingredient.Type: GrantFiled: July 9, 2001Date of Patent: November 23, 2010Assignee: New York UniversityInventors: Sylvia Lee-Huang, Philip L. Huang, Paul Huang
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Patent number: 7807174Abstract: The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.Type: GrantFiled: September 10, 2004Date of Patent: October 5, 2010Assignees: NexBio, Inc., The United States of America/NIHInventors: Fang Fang, Michael Malakhov
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Publication number: 20100183578Abstract: Specific nitroprotein biomarkers may be used as prognostic and diagnostic tools for COPD. Identification of certain specific nitroprotein biomarkers allows the development of targeted therapies aimed at prevention and treatment of COPD.Type: ApplicationFiled: December 29, 2009Publication date: July 22, 2010Applicant: Chiesi Farmaceutici S.p.A.Inventors: Dominic M. DESIDERIO, Xianquan Zhan
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Publication number: 20100151469Abstract: Stable compositions comprising a nucleic acid binding support material comprising a substrate with functional groups attached to the substrate; a lysing enzyme; a water dispersible matrix material; and a saccharide, methods of using the compositions, and products and devices which include the compositions are disclosed.Type: ApplicationFiled: April 25, 2008Publication date: June 17, 2010Inventors: Wensheng Xia, Ranjani V. Parthasarathy
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Publication number: 20100112664Abstract: Methods of making macroporous cation exchange resins are described. The macroporous cation exchange resins are in the form of particles such as beads that contain a hydrophilic, crosslinked, (meth)acrylic-type polymeric material. Additionally, methods of purifying a positively charged material using the macroporous cation exchange resins, methods of making chromatographic columns that contain the macroporous cation exchange resins, methods of making filter elements that contain the macroporous cation exchange resins, and methods of making porous composite materials that contain the macroporous cation exchange resins are described.Type: ApplicationFiled: January 15, 2010Publication date: May 6, 2010Inventors: Jerald K. Rasmussen, Robert T. Fitzsimons, JR., Kannan Seshadri, Simon K. Shannon, Peter D. Wickert, James I. Hembre
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Publication number: 20100095400Abstract: The present invention is in the field of plant biochemistry. More specifically the invention relates to nucleic acid sequences from plant cells, in particular, nucleic acid sequences from maize and soybean plants associated with the cytokinin pathway. The invention encompasses nucleic acid molecules that encode proteins and fragments of proteins. In addition, the invention also encompasses proteins and fragments of proteins so encoded and antibodies capable of binding these proteins or fragments. The invention also relates to methods of using the nucleic acid molecules, proteins and fragments of proteins and antibodies, for example for genome mapping, gene identification and analysis, plant breeding, preparation of constructs for use in plant gene expression and transgenic plants.Type: ApplicationFiled: December 7, 2009Publication date: April 15, 2010Inventors: Nordine Cheikh, Jingdong Liu
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Patent number: 7662607Abstract: A Chalaropsis lysozyme (Lysozyme Ch) is provided which has a corrected amino acid sequence and which can be utilized to prepare recombinant proteins having higher activity than those proteins using the incorrect sequence. Methods are also provided to reduce immunogenicity or increase half-life of the lysozyme. The lysozyme Ch of the present invention will be extremely useful in killing bacteria, particularly resistance strains such as MRSA and VISA, and the enzyme can be utilized in a variety of settings wherein bacterial infection has been a particular problem such as the hospital setting or in veterinary applications, and can also be used as an effective means of combating bioterror agents.Type: GrantFiled: July 30, 2004Date of Patent: February 16, 2010Assignee: New Century Pharmaceuticals, Inc.Inventors: Zhongmin Wang, Daniel C. Carter
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Patent number: 7658917Abstract: Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural amyloid aggregation. In a preferred embodiment, the compounds modulate the aggregation of natural ? amyloid peptides (?-AP). In a preferred embodiment, the ? amyloid modulator compounds of the invention are comprised of an A? aggregation core domain and a modifying group coupled thereto such that the compound alters the aggregation or inhibits the neurotoxicity of natural ? amyloid peptides when contacted with the peptides. Furthermore, the modulators are capable of altering natural ?-AP aggregation when the natural ?-APs are in a molar excess amount relative to the modulators. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.Type: GrantFiled: June 17, 2003Date of Patent: February 9, 2010Assignee: Praecis Pharmaceuticals, Inc.Inventors: Mark A. Findeis, Howard Benjamin, Marc B. Garnick, Malcolm L. Gefter, Arvind Hundal, Ethan R. Signer, James Wakefield, Laura Kasman, Gary Musso, Michael J. Reed
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Patent number: 7635471Abstract: A xylanase gene, denoted xynR8, encoding a xylanase (XynR8) obtained from the unisolated rumen microorganisms is provided. The DNA sequence of the xynR8 gene, xylanase, is also provided, the enzyme is thermostable, and highly specific for xylans with high activity. Transformation of microbial hosts with the xynR8 gene is described. A method for degrading the xylan-containing structure comprises hydrolyzing the ?-1,4-glycosidic bonds of xylans by contacting xylanase is provided, and a composition employing the above-mentioned hydrolyzing method is further addressed.Type: GrantFiled: August 21, 2006Date of Patent: December 22, 2009Assignee: Genozyme Biotech Inc.Inventors: Kou-Joan Cheng, Yo-Chia Chen, Hsueh-Ling Cheng, Shiou Hua Lin, Je Ruei Liu, Bi Yu