Aspergillus Patents (Class 435/256.1)
  • Patent number: 11598226
    Abstract: An energy storage system converts variable renewable electricity (VRE) to continuous heat at over 1000° C. Intermittent electrical energy heats a solid medium. Heat from the solid medium is delivered continuously on demand. An array of bricks incorporating internal radiation cavities is directly heated by thermal radiation. The cavities facilitate rapid, uniform heating via reradiation. Heat delivery via flowing gas establishes a thermocline which maintains high outlet temperature throughout discharge. Gas flows through structured pathways within the array, delivering heat which may be used for processes including calcination, hydrogen electrolysis, steam generation, and thermal power generation and cogeneration. Groups of thermal storage arrays may be controlled and operated at high temperatures without thermal runaway via deep-discharge sequencing. Forecast-based control enables continuous, year-round heat supply using current and advance information of weather and VRE availability.
    Type: Grant
    Filed: February 9, 2022
    Date of Patent: March 7, 2023
    Assignee: Rondo Energy, Inc.
    Inventors: John Setel O'Donnell, Peter Emery von Behrens, Chiaki Treynor, Jeremy Quentin Keller, Matthieu Jonemann, Robert Ratz, Yusef Desjardins Ferhani
  • Patent number: 9375015
    Abstract: The present invention provides a stabilized water dispersible granule biocontrol composition comprising at least one non-toxigenic strain of Aspergillus, at least one water-soluble filler and at least one anionic surfactant.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: June 28, 2016
    Assignee: Syngenta Participations AG
    Inventors: Tammy Lynn Tyler, James Alan Swanson
  • Patent number: 8900647
    Abstract: The purpose of the present invention is to breed a koji mold, which has improved capability of producing a variety of industrially applicable enzymes, without using the genetic recombination technology. By mutagenizing a strain belonging to the genus Aspergillus, a strain having a duplication of a large-scale genome region of 900 kb or more and is able to produce a variety of enzymes required in manufacturing soy sauce, for example, protease, etc. was obtained. This strain enables efficient production of various foods such as soy sauce.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: December 2, 2014
    Assignee: Kikkoman Corporation
    Inventors: Atsushi Sato, Yoshiki Hanya
  • Patent number: 8815548
    Abstract: The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: August 26, 2014
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Zachary Q. Beck, Anthony R. Calabria, Michael C. Miller, Alex T. Nielsen, Dmitrii V. Vaviline
  • Patent number: 8795984
    Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more ?-1,2-mannosidases.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: August 5, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Piotr Bobrowicz, W. James Cook, Warren Kett
  • Patent number: 8765404
    Abstract: Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. Some aspects of this invention relate to engineered microbes for biofuel or biofuel precursor production.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: July 1, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Syed Hussain Imam Abidi
  • Publication number: 20140162337
    Abstract: The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA pathway, iron-sulfur cluster-interacting redox polypeptides, and isoprene synthase. The invention also provides compositions that include these cultured cells.
    Type: Application
    Filed: July 11, 2013
    Publication date: June 12, 2014
    Applicants: The Goodyear Tire & Rubber Company, Danisco US Inc.
    Inventors: Gopal K. CHOTANI, Joseph C. MCAULIFFE, Michael C. MILLER, Rachel E. MUIR, Dmitrii V. VAVILINE, Walter WEYLER
  • Patent number: 8741626
    Abstract: The present invention relates to a mutant strain of Aspergillus sojae with an enhanced protease activity and a preparation method of a natural taste enhancer using the same. More specifically, the present invention relates to the mutant strain of Aspergillus sojae with an enhanced protease activity is obtained by selecting a strain with high protease activity and treating it with N-methyl-N?-Nitroso-N-nitrosoguanidine (NTG) and inducing a mutation through irradiating, and a preparation method of a natural taste enhancer using protein hydrolysate obtained by hydrolyzing the protein sources with their cultures.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: June 3, 2014
    Assignee: CJ Cheiljedang Corporation
    Inventors: Hyun Chi, Seong-Jun Cho
  • Publication number: 20140106398
    Abstract: The present invention relates to a host cell deficient in an essential gene, comprising a vector, said vector comprising at least said essential gene and an autonomous replication sequence, wherein the host cell is a filamentous fungal cell. The invention also relates to a host cell deficient in an essential gene, comprising a vector, said vector comprising at least said essential gene and an autonomous replication sequence, wherein the host cell comprises a recombinant polynucleotide construct comprising a polynucleotide encoding a biological compound of interest or a compound involved in the synthesis of a biological compound of interest.
    Type: Application
    Filed: March 12, 2012
    Publication date: April 17, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Roelof Ary Lans Bovenberg, Jan Andries Kornelis Willem Kiel, Thibaut José Wenzel, Alrik Pieter Los
  • Publication number: 20140065172
    Abstract: The present invention relates to a delivery system that comprises a conjugate that facilitates the delivery of a compound such as a biologically-active macromolecule, a nucleic acid or a peptide in particular, into a cell. The present invention also relates to said conjugate for delivery of a compound, such as a biologically-active macromolecule, a nucleic acid or a peptide, into a cell. The present invention further relates to a pharmaceutical composition comprising said conjugate and to its use. The present invention also relates to a method of delivering a compound to a cell or an organism, preferably a patient.
    Type: Application
    Filed: January 26, 2012
    Publication date: March 6, 2014
    Inventors: Christophe J. Echeverri, Birte Sönnichsen, Reinhard Wähler, Mike Werner Helms, Brian S. Sproat
  • Patent number: 8637002
    Abstract: Non-toxigenic strains of Aspergillus are useful biocontrol agents for preventing toxin contamination in agricultural commodities, especially those for human consumption such as peanuts and corn, for example.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: January 28, 2014
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Joe W. Dorner, Bruce W. Horn
  • Publication number: 20140017767
    Abstract: The present invention relates to microbial inocula and in particular to standardised inocula for producing reference cultures of microorganisms. The invention has been developed primarily for use as a solid, disc-shaped, inoculum and will be described hereinafter with reference to this application. However, it will be appreciated that the invention is not limited to this particular field of use.
    Type: Application
    Filed: June 21, 2013
    Publication date: January 16, 2014
    Applicant: AMS Laboratories Pty Ltd
    Inventors: Paul PRISCOTT, Yi-hong WANG
  • Patent number: 8580557
    Abstract: The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: November 12, 2013
    Assignee: Calpis Co., Ltd.
    Inventors: Naoyuki Yamamoto, Seiichi Mizuno, Takanobu Gotou, Keiichi Matsuura, Tadashi Shinoda, Hideo Nishimura
  • Publication number: 20130288340
    Abstract: An object of the present invention is to provide a microorganism which is novel at the elemental composition level, and to provide a technique for providing such a microorganism. The present inventor has succeeded in causing a microorganism to efficiently contain a non-essential element by decreasing the content of an essential nutrient source for the microorganism, a C source, an N source, a P source, or an S source, and by adding an X compound containing the non-essential element as a constitutive element in a manner to make up for the decreased amount, and then culturing the microorganism.
    Type: Application
    Filed: September 5, 2011
    Publication date: October 31, 2013
    Applicants: PARA MICROBIOS LABORATORIES LLC
    Inventor: Yoshitake Tanaka
  • Patent number: 8569038
    Abstract: The purpose of the present invention is to provide a strain having a significantly increased frequency of homologous recombination, which is necessary for gene disruption of gene replacement by gene targeting of a mitosporic filamentous fungus. This invention relates to a transformant having an increased frequency of homologous recombination (gene targeting), which is a mitosporic filamentous fungus belonging to Trichocomaceae, due to suppression of a ku gene by ku gene disruption or antisense RNA method, to a method for the production of a gene-disruption stain, gene-deletion strain, gene-replacement strain, gene-insertion strain or chromosome-modification strain by means of the gene targeting method using said transformant, and to the above-mentioned ku genes such as those derived from Aspergillus sojae and Aspergillus oryzae, and their expressed products (proteins).
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: October 29, 2013
    Assignee: Kikkoman Corporation
    Inventor: Tadashi Takahashi
  • Publication number: 20130280761
    Abstract: A novel microorganism is provided named Aspergillus saccharolyticus. Further, beta-glucosidase enzymes encoded by said microorganism are provided, and the use thereof in the degradation of lignocellulosic material. Also, host organisms comprising the polypeptides of the invention and/or polynucleotides encoding these are provided. In addition, methods, compositions, and kit-of-parts are provided which comprise any component of the invention, and optionally any additional components.
    Type: Application
    Filed: August 1, 2011
    Publication date: October 24, 2013
    Applicant: CLEANVANTAGE LLC
    Inventors: Philip Teller, Peter S. Lubeck, Annette Sorensen, Birgitte K. Ahring
  • Publication number: 20130219571
    Abstract: The invention relates to a polypeptide comprising the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 73% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 73% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional polypeptide and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.
    Type: Application
    Filed: June 23, 2011
    Publication date: August 22, 2013
    Applicant: DSM IP ASSETS B.V.
    Inventors: Margot Elisabeth Francoise Schoonneveld-Bergmans, Wilbert Herman Marie Heijne, Monica D. Vlasie, Robbertus Antonius Damveld
  • Patent number: 8501438
    Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more ?-1,2-mannosidases.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: August 6, 2013
    Assignee: GlycoFi, Inc.
    Inventors: Piotr Bobrowicz, W. James Cook, Warren Kett
  • Publication number: 20130122144
    Abstract: Disclosed is a glyceroglycolipid lipase which is highly safe, can hydrolyze a neutral fat, a glycerophospholipid or a glyceroglycolipid at about pH 6, is thermally stable to some extent, can hydrolyze lecithin, cannot hydrolyze lysolecithin, can rise a bread when used singly in the production of the bread, and has no unpleasant odor. Specifically disclosed is a glyceroglycolipid lipase derived from a filamentous bacterium Aspergillus japonicus.
    Type: Application
    Filed: November 21, 2012
    Publication date: May 16, 2013
    Inventors: KAORU TSUKAZAKI, TETSUYA FUKAZAWA, ISSHIN TANAKA
  • Publication number: 20130109049
    Abstract: The present invention provides a method of infecting a nail fragment with a fungus, to form an infected nail fragment comprising at least 1×102 fungal colony forming units (cfu) per cm2 of the infected surface(s). There is also provided a method of assessing the efficacy of potential therapeutic compounds in the treatment or prevention of a fungal nail infection. The fungal nail infection may be a dermatophyte, a non-dermatophyte mould or a pathogen.
    Type: Application
    Filed: December 20, 2010
    Publication date: May 2, 2013
    Applicant: NOVABIOTICS LIMITED
    Inventors: Deborah O'Neil, Derry Mercer, Colin Stewart
  • Patent number: 8431372
    Abstract: This invention is directed to methods of obtaining a high quantity of desired acid salt in a form that is relatively easy to recover. Particularly desired as a recovery product is an organic acid. A salt form of the desired organic acid is formed that is relatively high in concentration and that is relatively soluble in an aqueous medium. The method includes a step of fermenting a fermentable carbon source in the fermentation medium in the presence of a magnesium compound containing oxygen.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: April 30, 2013
    Assignee: MBI International
    Inventors: Michael V. Guettler, Robert J. Hanchar, Denise S. Rumler, Susanne Kleff
  • Publication number: 20130065810
    Abstract: The present invention is related to a fungal serine protease enzyme, which comprises an amino acid sequence of the mature Fe_RF6318 enzyme having an amino acid sequence of SEQ ID NO: 15. The serine protease is obtainable from Fusarium equiseti, more preferably from the deposited strain CBS 119568. Also disclosed are nucleic acid sequences encoding said protease, such as plasmid pALK2521 comprising the nucleotide sequence SEQ ID NO:9 deposited in E. coli RF7664 under accession number DSM 22171 and plasmid pALK2529 comprising the full-length gene SEQ ID NO: 10 deposited in E. coli RF7800 under accession number DSM 22172. Said protease is useful as an enzyme preparation applicable in detergent compositions and for treating fibers, for treating wool, for treating hair, for treating leather, for treating food or feed, or for any applications involving modification, degradation or removal of proteinaceous material.
    Type: Application
    Filed: April 28, 2010
    Publication date: March 14, 2013
    Applicant: AB Enzymes Oy
    Inventors: Kari Juntunen, Leena Valtakari, Susanna Makinen, Jarno Kallio, Jari Vehmaanpera, Pentti Ojapalo, Marja Paloheimo
  • Publication number: 20130035398
    Abstract: Methods of stimulating an increase in biomass by stimulating the growth, lifespan and/or reproduction of organisms such as fungi, algae, plants, and other aquatic organisms are provided by applying an effective amount of functionalized fullerenes. For example, polyhydroxy fullerenes are effective at low levels of promoting the increase in biomass.
    Type: Application
    Filed: April 7, 2011
    Publication date: February 7, 2013
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Jie Gao, Vijay Krishna, Wei Bai, Benjamin L. Koopman, Brij M. Moudgil, Paul Anthony Indeglia, Kevin Michael Folta, Angelina Tsenova Georgieva
  • Patent number: 8361762
    Abstract: The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: January 29, 2013
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Zachary Q. Beck, Anthony R. Calabria, Michael C. Miller, Dmitrii V. Vaviline, Alex T. Nielsen
  • Publication number: 20130011906
    Abstract: The present invention is a new additive material that is physically blended with polymeric material to create at least a partially biodegradable product.
    Type: Application
    Filed: July 17, 2012
    Publication date: January 10, 2013
    Applicant: BIO-TEC ENVIRONMENTAL, LLC
    Inventors: John Allen Lake, Samuel David Adams
  • Publication number: 20120329138
    Abstract: A process for separation of a mixture containing a microbial substance and a liquid using deformable filter is provided.
    Type: Application
    Filed: December 19, 2011
    Publication date: December 27, 2012
    Applicant: SHELL OIL COMPANY
    Inventors: Henry Van Kaathoven, Johannes Pieter Haan, Wilhelmus Maria Bond, Johannes Leendert Willem Cornelis Den Boestert
  • Publication number: 20120295335
    Abstract: A method to prevent contamination of feed line(s) and nutrient feed reservoirs(s) is disclosed. In this method the growth medium which flows from the nutrient feed reservoir through the feed line to the bioreactor contains at least one nutritional component supplied at a concentration which is inhibitory to cell growth. The inhibitory nutritional component in the growth medium prevents back growth of cells from the bioreactor into the feed line(s). The growth medium with inhibitory nutritional component is diluted in the bioreactor.
    Type: Application
    Filed: November 16, 2011
    Publication date: November 22, 2012
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventor: Scott Christopher Jackson
  • Publication number: 20120294981
    Abstract: A process for obtaining a treated backset for use in ethanol production, the process involving treating waste material from an ethanol fermentation process with microorganisms to remove or decrease microbial cell growth inhibitors present in the waste material; and removing microbial biomass from the treated waste material to form a treated backset. The treated backset can be used in a process for producing ethanol from a fermentable biomass. Recovered microbial biomass can be used in as an animal feed or as a dietary supplement.
    Type: Application
    Filed: May 4, 2012
    Publication date: November 22, 2012
    Applicant: NORTH AMERICAN PROTEIN, INC.
    Inventors: Jeffrey B. Wicking, Yilin Bian, Anbin Pu, Ping Liu
  • Publication number: 20120282233
    Abstract: The disclosure describes fungal organisms and preparations useful for inhibiting infection by Xylella sp. and in the treatment of Pierce's Disease.
    Type: Application
    Filed: April 20, 2012
    Publication date: November 8, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Philippe Rolshausen, Mary Caroline Roper
  • Publication number: 20120258104
    Abstract: The present invention relates to a delivery system that comprises a conjugate that facilitates the delivery of a compound such as a biologically-active macromolecule, a nucleic acid or a peptide in particular, into a cell. The present invention also relates to said conjugate for delivery of a compound, such as a biologically-active macromolecule, a nucleic acid or a peptide, into a cell. The present invention further relates to a pharmaceutical composition comprising said conjugate and to its use. The present invention also relates to a method of delivering a compound to a cell or an organism, preferably a patient.
    Type: Application
    Filed: July 22, 2010
    Publication date: October 11, 2012
    Applicant: Cenix Bioscience GMBH
    Inventors: Christophe J. Echeverri, Birte Sonnichsen, Reinhard Wähler, Mike Werner Helms
  • Publication number: 20120202262
    Abstract: The invention relates to a process for production of an enzyme product having a plurality of enzyme activities obtained by fermentation of an Aspergillus strain.
    Type: Application
    Filed: December 21, 2009
    Publication date: August 9, 2012
    Applicant: Danisco A/S
    Inventor: Mette Zacho Gronfeldt
  • Publication number: 20120183507
    Abstract: Non-toxigenic strains of Aspergillus are useful biocontrol agents for preventing toxin contamination in agricultural commodities, especially those for human consumption such as peanuts and corn, for example.
    Type: Application
    Filed: January 19, 2011
    Publication date: July 19, 2012
    Inventors: Joe W. Dorner, Bruce W. Horn
  • Patent number: 8206949
    Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more ?-1,2-mannosidases.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: June 26, 2012
    Assignee: GlycoFi, Inc.
    Inventors: Piotr Bobrowicz, W. James Cook, Warren Kett
  • Publication number: 20120156759
    Abstract: A method for the biological decomposition of organic compounds of the group of hydrocarbons, fats, oils, waxes, and derivatives thereof as well as mixtures thereof in media polluted therewith, in the presence of at least one dispersant, wherein the medium polluted with the pollutants is treated with at least one dispersant and with microorganisms.
    Type: Application
    Filed: June 15, 2010
    Publication date: June 21, 2012
    Applicants: TOTAL RAFFINAGE & MARKETING, GEORG FRITZMEIER GMBH & CO. KG
    Inventors: Ursula Fritzmeier, Robert Mallee, Achim Wiessler
  • Publication number: 20120142057
    Abstract: The present invention provides a method capable of producing a natural or recombinant protein in high yield. The present invention relates to a method of producing a polypeptide, comprising culturing a cell which strongly expresses cysteine sulfinic acid decarboxylase and has a transferred DNA encoding a desired polypeptide and thereby allowing the cell to produce the polypeptide. Hamster cysteine sulfinic acid decarboxylase, a DNA encoding the same, a recombinant vector and a transformed cell are also provided.
    Type: Application
    Filed: February 8, 2012
    Publication date: June 7, 2012
    Inventors: Hisahiro Tabuchi, Satoshi Tainaka, Tomoya Sugiyama
  • Publication number: 20120124898
    Abstract: This invention provides co-cultures of photosynthetic microorganisms and biofuel producing microorganisms. In certain embodiments, polysaccharide-producing, photosynthetic microorganisms are microalgae having frustules provide a substrate on which biofuel-producing microorganisms can grow. In other embodiments, the photosynthetic microorganisms produce a lipid and the non-photosynthetic microorganisms produce a solvent in which the lipid is soluble.
    Type: Application
    Filed: July 21, 2011
    Publication date: May 24, 2012
    Inventor: Pamela R. Contag
  • Publication number: 20120115191
    Abstract: There is provided a new strain, that is Aspergillus fumigatus, MTCC 5453, and its use in the production of fructo-oligosaccharide. The invention also provides an efficient, rapid and method for increased production of fructo-oligosaccharide by using the strain Aspergillus fumigatus MTCC 5453.
    Type: Application
    Filed: February 28, 2010
    Publication date: May 10, 2012
    Inventors: Samir S. Somaiya, Sangeeta Srivastava, Martin Annette, Amol Dive
  • Publication number: 20120108540
    Abstract: The invention comprises a process for producing a chitosan derivative, and a product prepared thereby, by activating chitosan or a chitosan precursor chitin in alcohol that contains water from 0% to maximum of about 30% and preparing derivatives by reacting with a reagent to get derivatives that have various uses including an antimicrobial, or a microbiostatic, or an antitranspirant, or an antifungal, or a fruit preservative properties or as carrier of active molecules or functional groups etc. or a combination thereof. Illustrated derivatives include acid, succinic, enzymatically deacetylated, enzymatically hydrolysed by chitinolysis, sugar, formaldehyde, phosphoric acid, hydrochloric acid and copper sulfate derivatives that are obtained by reaction individually or in a combination of consecutive reactions.
    Type: Application
    Filed: July 7, 2010
    Publication date: May 3, 2012
    Applicant: CAMLIN FINE SCIENCES LIMITED
    Inventor: Abhay Parashuram Shendye
  • Publication number: 20120100589
    Abstract: A method for treatment of a material comprising lignocellulosic fibres is disclosed. More particularly, the treatment increases the accessibility of the lignocellulosic fibres for following microbial or biological processes.
    Type: Application
    Filed: March 8, 2010
    Publication date: April 26, 2012
    Applicants: XERGI A/S, NOVOZYMES A/S
    Inventors: Danielle Rhine, Anders Peter Jensen, Stefan Borre-Gude
  • Patent number: 8114626
    Abstract: The present invention embraces a fungal strain deficient in nicotinamide riboside import and salvage and use thereof for producing nicotinamide riboside. Methods for producing nicotinamide riboside and a nicotinamide riboside-supplemented food product using the strain of the invention are also provided.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: February 14, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Charles Brenner, Peter Belenky, Katrina L. Bogan
  • Publication number: 20120034648
    Abstract: The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.
    Type: Application
    Filed: March 5, 2009
    Publication date: February 9, 2012
    Inventors: Paul Klaassen, Jan Metske Van Der Laan, Bianca Elisabeth Maria Gielesen, Gijsberdina Pieternella Van Suylekom
  • Publication number: 20120030839
    Abstract: The invention provides a method for the expression and subsequent screening of DNA libraries, particularly synthetic, genomic, and cDNA libraries, in filamentous fungal hosts. In particular, the invention provides vectors, host strains, and a method for the expression and screening of complex DNA libraries, including, but not limited to, combinatory (combinatorial) libraries expressing one, two or more variable constituents and/or prepared from two or more sublibraries (e.g., for the expression and screening of immunoglobulin (including fragments and derivatives of whole immunoglobulin proteins) and other receptor or complex DNA libraries or libraries of libraries). The invention is useful for the expression and screening for a large variety of proteins and protein complexes, including human proteins. The present invention also relates to novel fungal protease sequences.
    Type: Application
    Filed: December 10, 2007
    Publication date: February 2, 2012
    Applicant: DYADIC INTERNATIONAL, INC.
    Inventors: Mark A. Emalfarb, Peter J. Punt, Cornelia Van Zeijl, Cornelius Van Den Hondel, Jan Verdoes, Richard P. Burlingame
  • Publication number: 20120028332
    Abstract: The invention relates to a process for production of an enzyme product having a plurality of enzyme activities obtained by fermentation of an Aspergillus strain.
    Type: Application
    Filed: December 21, 2009
    Publication date: February 2, 2012
    Applicant: Danisco A/S
    Inventor: Mette Zacho Gronfeldt
  • Publication number: 20120027910
    Abstract: The purpose of the present invention is to breed a koji mold, which has improved capability of producing a variety of industrially applicable enzymes, without using the genetic recombination technology. By mutagenizing a strain belonging to the genus Aspergillus, a strain having a duplication of a large-scale genome region of 900 kb or more and is able to produce a variety of enzymes required in manufacturing soy sauce, for example, protease, etc. was obtained. This strain enables efficient production of various foods such as soy sauce.
    Type: Application
    Filed: April 16, 2010
    Publication date: February 2, 2012
    Applicant: KIKKOMAN CORPORATION
    Inventors: Atsushi Sato, Yoshiki Hanya
  • Publication number: 20120003626
    Abstract: The present disclosure describes methods for concentrating microorganisms with concentration agents in a sampling device and the sampling device described herein. More specifically, methods for concentrating microorganisms from large volume samples with concentration agents in a sampling device can provide for rapid, low cost, simple (involving no complex equipment or procedures), and/or effective processes under a variety of conditions.
    Type: Application
    Filed: December 30, 2009
    Publication date: January 5, 2012
    Inventors: Manjiri T. Kshirsagar, Kurt J. Halverson, Neil Percy, James E. Aysta
  • Publication number: 20120003740
    Abstract: This document discloses electroporation vessels, electrocompetent cells that have been aliquoted and frozen in electroporation vessels, and a number of other apparatuses, kits, and methods for electroporation. Some embodiments of electroporation vessels described herein may include a pair of opposing walls that are downwardly angled toward one another in a gap between two electrode surfaces. Further embodiments of devices and methods described herein may eliminate the need for an end user to transfer competent cells from a capped tube to electroporation cuvette, thereby saving time and producing less waste.
    Type: Application
    Filed: December 28, 2010
    Publication date: January 5, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Laura Vozza-Brown, Harry Yim, John Cameron, Matthew O'Banion, Adam Scott Henry, Lisa Marie Olivier
  • Publication number: 20110236531
    Abstract: Disclosed is a glyceroglycolipid lipase which is highly safe, can hydrolyze a neutral fat, a glycerophospholipid or a glyceroglycolipid at about pH 6, is thermally stable to some extent, can hydrolyze lecithin, cannot hydrolyze lysolecithin, can rise a bread when used singly in the production of the bread, and has no unpleasant odor. Specifically disclosed is a glyceroglycolipid lipase derived from a filamentous bacterium Aspergillus japonicus.
    Type: Application
    Filed: January 30, 2008
    Publication date: September 29, 2011
    Applicant: MITSUBISHI-KAGAJU FOODS CORPORATION
    Inventors: Kaoru Tsukazaki, Tetsuya Fukazawa, Isshin Tanaka
  • Publication number: 20110212504
    Abstract: The present application provides a method of producing a carboxylesterase or its variant in eukaryotic cells. The present application also provides an expression vector for high level carboxylesterase expression, a eukaryotic cell comprising the expression vector, and uses thereof. The present application also provides a composition comprising a carboxylesterase or its variant produced by a method described in the present application and uses of the composition.
    Type: Application
    Filed: June 2, 2010
    Publication date: September 1, 2011
    Applicant: TONGJI UNIVERSITY
    Inventor: Zhongbin Liu
  • Publication number: 20110189726
    Abstract: The invention relates to a process for obtaining monacolin J derivatives (I), wherein R1 is COR2, wherein R2 is selected from C1-C15 alkyl, C3-C15 cycloalkyl, C2-C15 alkenyl, C2-C15 alkynyl, aryl and heterocyclyl; which comprises producing monacolin J by fermentation from a monacolin J-producing microorganism; and acylating the hydroxyl group present in the C8 position of the monacolin J previously obtained by means of adding a suitable acylating agent to the fermentation medium to obtain the desired monacolin J derivative (I).
    Type: Application
    Filed: October 14, 2009
    Publication date: August 4, 2011
    Applicant: NEURON BIOPHARMA, S.A.
    Inventors: Sonia Campoy Garcia, Alberto Zafea Gómez, José Luis Adrio Fondevila, Javier Velasco Alvarez
  • Patent number: 7982057
    Abstract: The present invention relates to novel compound of stemphones obtained by culturing microorganism belonging to genus Aspergillus and having ability to produce compound of stemphones selected from the group consisting of stemphone D substance, stemphone E substance, stemphone E1 substance, stemphone E2 substance, stemphone E3 substance and stemphone F substance, accumulating the compound of stemphones in the cultured mass, and isolating the compound of stemphones from the cultured mass. Since the obtained compound has enhancing activity for imipenem and activity for reducing cytotoxicity, it can be expected to be useful as lead compounds for combination remedy for methicillin resistant Staphylococcus aureus (MRSA) infection.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: July 19, 2011
    Assignee: The Kitasato Institute
    Inventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuda