Micro-organism, Per Se (e.g., Protozoa, Etc.); Compositions Thereof; Proces Of Propagating, Maintaining Or Preserving Micro-organisms Or Compositions Thereof; Process Of Preparing Or Isolating A Composition Containing A Micro-organism; Culture Media Therefor Patents (Class 435/243)
  • Patent number: 11542321
    Abstract: This invention relates to engineered CH2 domain molecules containing amino acids in the framework regions that confer enhanced stability and/or solubility. In particular, the invention provides engineered CH2 domain molecules containing amino acid residues that differ from a wild type CH2 domain or a template CH2 domain molecule within one or more framework regions and that result in improved stability and/or solubility.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: January 3, 2023
    Assignee: Research Corporation Technologies, Inc.
    Inventor: Kurt R. Gehlsen
  • Patent number: 11534722
    Abstract: A gas separation apparatus includes a separation membrane module including at least one gas separation membrane element in a housing, a casing for blocking external air, and a heat source unit for adjusting a temperature of a heat medium with which the casing is filled. The casing holds greater than or equal to two separation membrane modules.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: December 27, 2022
    Assignees: SUMITOMO CHEMICAL COMPANY, LIMITED, RENAISSANCE ENERGY RESEARCH CORPORATION
    Inventors: Nobutaka Kodama, Takehiro Nakasuji, Osamu Okada, Masaaki Teramoto, Nobuaki Hanai
  • Patent number: 11530426
    Abstract: The disclosure provides a method for biohydrogen production. The method includes: mixing a hydrogen production medium and a buffer solution Na2HPO4/NaH2PO4 having a pH value of 5-9, to yield a first mixture; adding corn stalk powder and cellulase to the first mixture and mixing, to yield a second mixture; adding a suspension of photosynthesis bacteria HAU-M1 at the late exponential phase to the second mixture, to yield a third mixture; and sealing the third mixture and allowing for photo-fermentation biohydrogen production under anaerobic fermentation conditions.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: December 20, 2022
    Assignee: HENAN AGRICULTURAL UNIVERSITY
    Inventors: Chaoyang Lu, Quanguo Zhang, Zhiping Zhang, Danping Jiang, Yanyan Jing, Yi Wang, Kaixin Wang, Siyi Guo, Jian Wang
  • Patent number: 11491233
    Abstract: Disclosed herein are functionalized hyaluronic acid (HA), a responsive elastic polymer system comprising functionalized HA, and methods of fabrication and utilization of the same. This polymer system may be used for controlled local or systemic drug delivery release of analgesics, anesthetics, antibiotics and other drugs as well as tissue engineering articles.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: November 8, 2022
    Assignee: Purdue Research Foundation
    Inventors: Meng Deng, Liangju Kuang
  • Patent number: 11477989
    Abstract: The invention relates to a particulate product comprising at least 10 wt. % of the coated acetate particles having the following characteristics: (a) comprising one or more carrier particles containing at least 80 wt. % of sodium acetate component selected from sodium acetate hydrates, sodium acetate anhydrous and combinations thereof; (b) comprising a coating layer that covers the one or more carrier particles, said coating layer containing at least 60 wt. % of potassium acetate; (c) containing potassium and sodium in a molar ratio of 0.4:1 to 5:1; and (d) a particle size in the range of 40 to 1,000 ?m. The coated acetate particles in the particulate product are very stable, even though the potassium acetate in the coating layer is in direct contact with the surrounding atmosphere. The particulate product can suitably be used in the preparation of foodstuffs and beverages.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: October 25, 2022
    Assignee: PURAC BIOCHEM B.V.
    Inventors: Lambertus Henricus Elisabeth Roozen, Gerrit Anthon Rene Hilhorst, Heny Kusumawardani, Apostolos Papageorgiou, Kees Van Der Voort Maarschalk
  • Patent number: 11466269
    Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR-Cas system for a Labyrinthulomycetes host cell.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: October 11, 2022
    Assignee: DSM IP ASSETS B.V.
    Inventors: James Casey Lippmeier, Yelena Betz, Johannes Andries Roubos, René Verwaal
  • Patent number: 11452773
    Abstract: The invention relates to an immunization regimen whereby an infant is protected against respiratory syncytial virus (RSV) through administration of a first anti-RSV immune response inducing composition to his or her mother during pregnancy, followed by administration of a second anti-RSV immune response inducing composition to the infant after birth.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: September 27, 2022
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventor: Philip Dormitzer
  • Patent number: 11447732
    Abstract: Cell culture systems and methods provide improved immunotherapeutic product manufacturing with greater scalability, flexibility, and automation. Cell culture systems are configured with interchangeable cartridges, allowing versatility and scalability. Systems are configured to have multiple connected cell culture chambers, which allows parallel processing of different types of cells. Gas-impermeable cell culture chambers and methods for generating cells in closed systems prevent contamination and user error. Methods for recycling cell culture medium provide additional efficiencies.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: September 20, 2022
    Assignee: FLASKWORKS, LLC
    Inventors: Shashi K. Murthy, Andrew Kozbial
  • Patent number: 11432575
    Abstract: Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: September 6, 2022
    Assignee: THE FYNDER GROUP, INC.
    Inventors: Richard Eugene Macur, Yuval Charles Avniel, Renata Usaite Black, Maximilian DeVane Hamilton, Michael John Harney, Eleanore Brophy Eckstrom, Mark Andrew Kozubal
  • Patent number: 11370816
    Abstract: Synthetic histatins composed of combinations of functional domains of natural histatins separated by exogenous linkers are described as are methods of using endogenous and synthetic histatins for the treatment of ocular diseases or conditions.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: June 28, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Vinay Aakalu
  • Patent number: 11338294
    Abstract: Toward forming a single hybrid biosensing-imaging system that can operate inside an incubator, structures and methods are directed to placing modular and removable biosensors and biocompatible interfaces in 3D transparent test wells that contain biological samples. The technology enables continuous monitoring of multiple simultaneous parameters and functions of a living cell or cell clusters such as alterations of cellular ligands, physicochemical biomarkers, phenotypes, and/or extracellular compositions upon interactions with analytes or during progressions. Methods of capturing and analyzing direct orthogonal information from biological samples in 2D and 3D, which are conducive to generating new insights are presented.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: May 24, 2022
    Assignee: Polybiomics, Inc.
    Inventors: Mandana Veiseh, Pirooz Parvarandeh, S. Bahram Bahrami, Oliver Peter King-Smith, Todd S. Rutherford, Aaron Peter Schellenberg, Timothy Scott Edward Hiller
  • Patent number: 11293046
    Abstract: The invention provides devices and methods for automatically preparing pure cultures of microbial cells under native environmental conditions. The devices and methods permit the discovery and investigation of novel microorganisms having unknown culture requirements from natural environments and microbiomes. Cultures obtained using the invention lead to the identification and isolation of novel biologically active compounds. The devices utilize a single entry pore in a thin membrane to select a single cell for clonal expansion.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: April 5, 2022
    Assignee: Northeastern University
    Inventor: Slava Epstein
  • Patent number: 11278027
    Abstract: Use of the molecule with the following formula (I) for its fungicidal and/or bactericidal activity on fungi, oomycetes and/or pathogenic bacteria of plants and crop seeds.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: March 22, 2022
    Assignee: Immunrise Biocontrol France
    Inventors: Yann Thomas, Odon Thiebeauld
  • Patent number: 11278609
    Abstract: Medicament for the treatment or the prevention of a bacterial infection, characterized in that it contains at least one polypeptide selected from the group of SEQ ID NO: 1 to SEQ ID NO: 9, and contiguous fragments thereof, wherein said at least one polypeptide or contiguous fragment thereof induces opsonic antibodies in a patient in need thereof. The polypeptides or the contiguous fragments thereof according to the present invention can be used for the preparation of a vaccine against an infection against Enterococcus.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: March 22, 2022
    Assignees: KLINIKUM DER UNIVERSITÄT MÜNCHEN, UNIVERSITE DE CAEN BASSE-NORMANDIE
    Inventors: Johannes Hübner, Axel Hartke, Luis Felipe Romero Saavedra
  • Patent number: 11274321
    Abstract: Compositions and methods for a hybrid biological and chemical process that captures and converts carbon dioxide and/or other forms of inorganic carbon and/or CI carbon sources including but not limited to carbon monoxide, methane, methanol, formate, or formic acid, and/or mixtures containing CI chemicals including but not limited to various syngas compositions, into organic chemicals including biofuels or other valuable biomass, chemical, industrial, or pharmaceutical products are provided. The present invention, in certain embodiments, fixes inorganic carbon or CI carbon sources into longer carbon chain organic chemicals by utilizing microorganisms capable of performing the oxyhydrogen reaction and the autotrophic fixation of CO2 in one or more steps of the process.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: March 15, 2022
    Assignee: Kiverdi, Inc.
    Inventors: John S. Reed, Lisa Dyson
  • Patent number: 11248032
    Abstract: Provided are a method for producing a soluble recombinant human-basic fibroblast growth factor (rh-bFGF), a recombinant human-basic fibroblast growth factor (rh-bFGF) obtained by the method, and a mutated nucleic acid molecule encoding the recombinant human-basic fibroblast growth factor (rh-bFGF).
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: February 15, 2022
    Assignee: ZHUHAI ESSEX BIO-PHARMACEUTICAL CO., LTD.
    Inventors: Haizhou Fang, Bo Yang, La Ma, Peimin Dai, Xinzhi Wang, Malcolm Ngiam, Qi Xue, Yongjun Yang
  • Patent number: 11162120
    Abstract: Described is a method for the enzymatic production of an acyl phosphate from a 2-hydroxyaldehyde using a phosphoketolase or a sulfoacetaldehyde acetyltransferase.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: November 2, 2021
    Assignees: Scientist of Fortune, S.A., Global Bioenergies
    Inventor: Philippe Marlière
  • Patent number: 11154858
    Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a bioreactor system having one or more wells with at least one fluidic passageway coupled to each well to feed fluids to biological material being developed inside the well. In some cases, a bioreactor system can include a main body comprising the perimeter of the well and the fluidic passageways, a cover that forms the top of the well and provides optical access into the well, and a base that forms the bottom surface of the well. The cover and base can be attached and detached from the main body to seal the well closed and to physically access the contents of the well.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: October 26, 2021
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Riccardo Gottardi, Peter Alexander, Bryan Romell, Rocky S. Tuan
  • Patent number: 11118197
    Abstract: In one aspect, the present invention provides methods for preparing a fermentation product. The methods include pre-treating a mixture of biomass and ionic liquid, wherein the ionic liquid comprises a choline cation and the biomass comprises polysaccharide and lignin. The methods further include forming hydrolysates from the introduction of glycoside hydrolase to the pre-treated mixture at conditions sufficient to produce a sugar composition mixture for fermentation steps. The present invention provides methods for loading biomass mixtures in a batch-fed process, wherein the biomass slurries can be loaded into water or a concentrated sugar composition for hydrolysate production. The methods can be performed in a one-pot process, wherein the ionic liquids are present in the mixtures throughout each step. Aspects of the invention provide compositions of sugar composition mixtures and fermentation product mixtures.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: September 14, 2021
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Feng Xu, Blake Simmons, Seema Singh
  • Patent number: 11053302
    Abstract: The present invention relates to single domain antibodies comprising at least one modification relative to the 4D5 antibody scaffold or human germline VH3 domain, the modifications selected from the group consisting of H35D, A78V, S93V, S93G and W103R, with the position numbering being according to the Kabat numbering scheme. Disulfide-free variants further comprise at least one additional modification selected from the group consisting of C22S, A24I, A24L and C92T, and with the proviso that at least one of C22S and C92T is present. Further encompassed are the multi-modular antibody molecules and antibody conjugates comprising single domain antibodies, as well as methods for producing them. The invention in particular provides a library of the single domain antibodies or multi-modular antibody molecules and a method for selecting an antibody that binds an antigen.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: July 6, 2021
    Assignee: Nanyang Technological University
    Inventors: Tobias Carl Cornvik, Ignacio Jose Asial, Par Lennart Nordlund
  • Patent number: 10996149
    Abstract: A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: May 4, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
  • Patent number: 10842870
    Abstract: The present invention relates to humanized anti-human GPVI antibodies and uses thereof.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: November 24, 2020
    Assignees: ACTICOR BIOTECH, UNIVERSITE DE PARIS, UNIVERSITÉ PARIS-XIII, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), UNIVERSITE PARIS-SACLAY
    Inventors: Philippe Billiald, Martine Jandrot-Perrus
  • Patent number: 10781417
    Abstract: An apparatus for processing cells is disclosed. In one embodiment, a fixed bed reactor is provided for the cells, the fixed bed reactor including a portion movable from a first position corresponding to a packed condition of the fixed bed to a second position corresponding to a depacked condition of the fixed bed. Movement of the partition facilitates harvesting of the cells there from. Related apparatus, kits, methods, and systems are also disclosed.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: September 22, 2020
    Assignees: PALL TECHNOLOGY UK LIMITED, PALL ARTELIS BVBA, PALL LIFE SCIENCES BELGIUM B.V.B.A.
    Inventors: Suresh Purushothaman, Jose Antonio Castillo Gonzalez, Jean-Christophe Drugmand, Vishwas Pethe, Derek Pendlebury, Fabien Moncaubeig
  • Patent number: 10745493
    Abstract: A graft copolymer comprising: a core polymer comprising a crosslinked or non-crosslinked polysaccharide, a plurality of primary graft polymers covalently grafted to the core polymer, a plurality of secondary graft polymers covalently grafted to each primary graft polymer, an injectable dermal aesthetic formulation comprising such a graft copolymer and a method of preparing such a graft copolymer.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: August 18, 2020
    Assignee: GALDERMA S.A.
    Inventor: Kristoffer Bergman
  • Patent number: 10704065
    Abstract: There is described a method for producing polymeric 3-hydroxypropionamide (3HP amide), the method comprising: culturing an Acetobacter lovaniensis-bacterium in a growth medium containing phosphate and ammonium, wherein culturing of the bacterium produces polymeric 3HP amide. The polymeric 3HP amide may then be hydrolysed to 3HP amide or converted to other compounds of interest.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: July 7, 2020
    Assignee: VERDANT BIOPRODUCTS LIMITED
    Inventor: Irene Finnegan
  • Patent number: 10626423
    Abstract: A non-naturally occurring microorganism having a 1,3-BDO pathway is provided. The microorganism expresses at least one of the following 1,3-BDO pathway enzymes: an aldolase that catalyzes condensation of two acetaldehydes to produce 3-hydroxybutanal; and an aldo-ketoreductase, oxidoreductase, aldehyde reductase or alcohol dehydrogenase that reduces 3-hydroxybutanal to 1,3-BDO. The organism may further express one or more enzymes for producing acetaldehyde. A biosynthetic process involves condensing two acetaldehyde molecules to 3-hydroxybutanal using an enzyme from class aldolases; and selectively reducing 3-hydroxybutanal to 1,3-BDO using an enzyme belonging to the class aldo-ketoreductase, oxidoreductase, aldehyde reductase or alcohol dehydrogenase. The process can further include producing acetaldehyde by a biosynthetic method.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: April 21, 2020
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Radhakrishnan Mahadevan, Alexander Yakunin, Pratish Gawand, Kayla Nemr
  • Patent number: 10588280
    Abstract: Provided herein are delivery methods of a plant treatment agent to a tissue of a plant, wherein the tissue is contacted with a plant treatment agent and delivery is aided by a centrifugal force applied to the plant. Disclosed herein is the discovery that drastic improvements in treatment delivery occur when plants are centrifuged after being contacted, submerged, unsubmerged, soaked, etc. in a solution containing a plant treatment agent. In one embodiment, haploid plants contacted with a colchicine solution are centrifuged to reveal improved chromosomal doubling rates as compared to control plants.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: March 17, 2020
    Assignee: Monsanto Technology LLC
    Inventors: Huachun Larue, Fenggao Dong
  • Patent number: 10519409
    Abstract: A fluid transfer assembly for single use bioreactors includes a fluid transfer housing that can be mounted to the impeller shaft using a bearing that places the fluid transfer assembly directly below the lowest impeller but allows the impeller shaft to spin inside independently of the fluid transfer assembly. A fluid conduit connects the fluid transfer housing to a port in the single use bag wall which allows fluids to be introduced into the sparger and which also helps prevent the fluid transfer assembly from rotating with the impeller shaft.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: December 31, 2019
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Richard Lee Damren, Colin R. Tuohey
  • Patent number: 10513722
    Abstract: Compositions, methods and kits are disclosed for synthesizing and amplifying pools of probes using precursor oligonucleotides. In some aspects the precursor is amplified and nicking enzymes are used to separate the full length probes from the amplification products. The methods enable the preparation of single stranded DNA probes of defined sequence and length that are suitable for use in target detection assays.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: December 24, 2019
    Inventors: Yuker Wang, Keith W. Jones, Ronald J. Sapolsky
  • Patent number: 10472605
    Abstract: A serum-free medium for the growth of mesenchymal stem cells comprises FGF, TGF-? and lipoprotein.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: November 12, 2019
    Assignee: National University of Ireland, Galway
    Inventors: Francis Peter Barry, Emma Jane Mooney, Josephine Mary Murphy, Georgina Margaret Shaw, Sean Patrick Gaynard
  • Patent number: 10457963
    Abstract: Nucleic acids and cells comprising a methyltransferase gene and/or a reductase gene are disclosed. These nucleic acids and cells may be used to produce branched (methyl)lipids, such as 10-methylstearate.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: October 29, 2019
    Assignee: Novogy, Inc.
    Inventors: Arthur J. Shaw, IV, Hannah Blitzblau, Donald V. Crabtree
  • Patent number: 10456448
    Abstract: The present technology provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to oral and gastric mucositis. Also provided are codon-optimized nucleic acids encoding for Smad7 fusion proteins.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: October 29, 2019
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Xiao-Jing Wang, Qinghong Zhang, Yosef Refaeli
  • Patent number: 10436795
    Abstract: Carbon-detected NMR is well-suited for mapping binding sites in intrinsically disordered regions of a polypeptides, and for mapping of binding motifs in intrinsically disordered regions with single-residue resolution. Provided are methods of carbon-detected NMR for determining the amino acids that mediate the interaction between an intrinsically disordered polypeptide or protein, or an intrinsically disordered region of a polypeptide, and a biomolecule such as another polypeptide or a nucleic acid.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: October 8, 2019
    Assignee: Institute For Cancer Research
    Inventors: Hong Cheng, Heinrich Roder
  • Patent number: 10412958
    Abstract: Provided is a device for vitrification-based cryopreservation which enables easy and reliable vitrification freezing of cells or tissues. The device of the present invention for cell or tissue cryopreservation by vitrification has a porous structure made of a material having a refractive index of 1.45 or less as a vitrification solution absorber.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: September 17, 2019
    Assignees: SCHOOL JURIDICAL PERSON KITASATO INSTITUTE, MITSUBISHI PAPER MILLS LIMITED
    Inventors: Kenji Momozawa, Atsushi Matsuzawa, Katsumitsu Susaki
  • Patent number: 10415074
    Abstract: A method for detecting lactic acid and/or acetic acid bacteria in a food-processing matrix is taught, using microbial flora including a lactic acid and/or acetic acid bacterial flora and a fungal flora. The bacterial flora contains an adenosine triphosphate of bacterial origin, and the fungal flora contains an adenosine triphosphate of fungal origin. The method comprises applying, to the matrix, before a first time limit, an antifungal having an antifungal action which is lethal, on the fungal flora, and at a second time limit, an antibiotic action which is non lethal, at a second time limit after the first time limit, on the bacterial flora. The microbial flora is detected between the first time limit and the second time limit; the lethal antifungal action releases, into the matrix, for the first time limit, adenosine triphosphate of fungal origin and in which the microbial flora is detected between the first time limit and the second time limit.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: September 17, 2019
    Inventor: Charles Cervin
  • Patent number: 10371695
    Abstract: The present invention relates to a method and tools for extracting information on a compounds influence on a cellular phenotype. The method of the invention may be used as a very efficient procedure for testing the efficacy or resistance of single drugs or combinations of drugs on cells from individual patients. Thus, the methods may be useful for predicting efficacy of a drug on a given patient. The methods are also useful for testing of compounds for toxicity, identifying drug targets for known or novel compounds.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: August 6, 2019
    Assignee: 2cureX ApS
    Inventors: Grith Hagel, Ole Thastrup
  • Patent number: 10364426
    Abstract: A process for reducing cell death in eukaryotic and prokaryotic organisms includes the steps of mixing the organisms with water in a first reactor, strobing light onto the mixture of organisms and water for a period of time, passing the strobed mixture into another reactor, and discharging the mixture from the another reactor. The step of strobing light includes strobing light to the mixture of organisms and water at a frequency of between 10 Hz and 40 Hz. The strobing of the light is between twenty flashes per second and eighty flashes per second. The first reactor is a continuously stirred reactor. The another reactor is a plug flow reactor. The organisms are in an algal culture.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: July 30, 2019
    Assignee: MISSING LINK TECHNOLOGY, LLC
    Inventor: Samuel L. Shepherd
  • Patent number: 10350554
    Abstract: A container assembly includes a flexible bag having an interior surface bounding a chamber and an opposing exterior surface, the bag having a bottom end wall being comprised of a first sheet overlying a second sheet, the first sheet and the second sheet of the bottom end wall being welded together so as to form a first sparging area and a separated second sparging area that are both bounded between the first sheet and the second sheet, at least a portion of the first sheet overlying the first and second sparging areas being gas permeable.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: July 16, 2019
    Assignee: Life Technologies Corporation
    Inventors: Michael E. Goodwin, Nephi D. Jones, Derik R. West
  • Patent number: 10342862
    Abstract: The invention relates to an immunization regimen whereby an infant is protected against respiratory syncytial virus (RSV) through administration of a first anti-RSV immune response inducing composition to his or her mother during pregnancy, followed by administration of a second anti-RSV immune response inducing composition to the infant after birth.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: July 9, 2019
    Assignee: GlaxoSmithKline Biologicals, SA
    Inventor: Phillip Dormitzer
  • Patent number: 10316298
    Abstract: Methods and compositions for producing fatty acid derivatives, for example, fatty esters, and commercial fuel compositions comprising fatty acid derivatives are described.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: June 11, 2019
    Assignee: REG Life Sciences, LLC
    Inventor: Alfred Gaertner
  • Patent number: 10316281
    Abstract: A cell culture apparatus includes cell culture units having cell culture chambers, each with at least one manifold. The manifold connects the cell culture unit to a fluid flow channel. The manifold has a dam which allows liquid to pool in the manifold and allows for the creation of an airspace in the manifold, which reduces hydrostatic pressure inside the apparatus and enables the stacking of multiple cell culture units. Embodiments include cascading manifolds, manifolds having reservoirs, and manifolds having valves.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: June 11, 2019
    Assignee: Corning Incorporated
    Inventors: David Alan Kenney, Gregory Roger Martin, Allison Jean Tanner, Joseph Christopher Wall
  • Patent number: 10265392
    Abstract: The present invention pertains to a vaccine comprising non live Lawsonia intracellularis antigen and a pharmaceutically acceptable carrier for use in a method to reduce in a pig the shedding of Lawsonia intracellularis bacteria associated with subclinical infection with Lawsonia intracellularis, by systemic administration of the vaccine to the pig.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: April 23, 2019
    Assignee: Intervet Inc.
    Inventor: Antonius Arnoldus Christiaan Jacobs
  • Patent number: 10238694
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: March 26, 2019
    Assignees: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Patent number: 10214713
    Abstract: The current is directed to a device comprising, a reaction chamber where a reaction takes place, one or more feeding chambers which contain feeding solution comprising chemicals required for the reaction, and one or more porous membranes separating the reaction chamber from the one or more feeding chambers, and wherein the one or more porous membranes are in substantially vertical position. The current invention is also directed to an apparatus comprising a plurality of devices, wherein each device comprises of a reaction chamber where a reaction takes place, one or more feeding chambers which contain feeding solution comprising chemicals required for the reaction, and one or more porous membranes which separate the reaction chamber from feeding chambers, wherein the one or more porous membranes are in substantially vertical position. These devices and apparatuses can be used for high throughput synthesis of biomolecules and chemicals and biological screening assays.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: February 26, 2019
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Zhonghui Hugh Fan, Kirsten Marie Jackson
  • Patent number: 10196609
    Abstract: The present invention provides a composition for promoting cardiac differentiation of a pluripotent stem cell containing an EGFR inhibitor. The present invention also provides a kit for promoting cardiac differentiation containing an EGFR inhibitor and a method for inducing cardiac differentiation of a pluripotent stem cell comprising culturing the pluripotent stem cell in a medium containing an EGFR inhibitor.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: February 5, 2019
    Assignee: KYOTO UNIVERSITY
    Inventors: Norio Nakatsuji, Itsunari Minami
  • Patent number: 10166258
    Abstract: This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and to identify effective growth factors are provided.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: January 1, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Allan B. Dietz, Michael P. Gustafson, Greg W. Butler
  • Patent number: 10151004
    Abstract: A method for specifically detecting and optionally for quantifying Mycobacterium avium ssp. paratuberculosis (MAP) in a sample of an individual is provided. For this purpose, the detection of the presence of the IS900 region in a sample is performed by nucleic acid amplification using specific oligonucleotides. In a further aspect, a test kit for specifically detecting MAP in a sample by amplification methods is also provided. Finally, specific oligonucleotides that are suitable for specifically detecting MAP are described.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: December 11, 2018
    Assignee: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts
    Inventors: Claus-Peter Czerny, Pia Muenster
  • Patent number: 10138284
    Abstract: An insulin analog comprises a B-chain polypeptide containing a cyclohexanylalanine substitution at position B24 and optionally containing additional amino-acid substitutions at positions A8, B28, and/or B29. A proinsulin analog or single-chain insulin analog containing a B domain containing a cyclohexanylalanine substitution at position B24 and optionally containing additional amino-acid substitutions at positions A8, B28, and/or B29. The analog may be an analog of a mammalian insulin, such as human insulin. A nucleic acid encoding such an insulin analog is also provided. A method of lowering the blood sugar of a patient comprises administering a physiologically effective amount of the insulin analog or a physiologically acceptable salt thereof to a patient. A method of semi-synthesis using an unprotected octapeptide by means of modification of an endogenous tryptic site by non-standard amino-acid substitutions.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: November 27, 2018
    Assignee: Case Western Reserve University
    Inventor: Michael A. Weiss
  • Patent number: 10124027
    Abstract: The present invention provides methods of designing panels of bacteriophages as therapeutic compositions against bacterial infections. The present invention also provides panels of bacteriophages for use in the prevention or treatment of bacterial infections.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: November 13, 2018
    Assignee: BIOCONTROL LIMITED
    Inventors: David Harper, Katy Blake
  • Patent number: 10058578
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: August 28, 2018
    Assignees: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita