Micro-organism, Per Se (e.g., Protozoa, Etc.); Compositions Thereof; Proces Of Propagating, Maintaining Or Preserving Micro-organisms Or Compositions Thereof; Process Of Preparing Or Isolating A Composition Containing A Micro-organism; Culture Media Therefor Patents (Class 435/243)
  • Patent number: 10371695
    Abstract: The present invention relates to a method and tools for extracting information on a compounds influence on a cellular phenotype. The method of the invention may be used as a very efficient procedure for testing the efficacy or resistance of single drugs or combinations of drugs on cells from individual patients. Thus, the methods may be useful for predicting efficacy of a drug on a given patient. The methods are also useful for testing of compounds for toxicity, identifying drug targets for known or novel compounds.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: August 6, 2019
    Assignee: 2cureX ApS
    Inventors: Grith Hagel, Ole Thastrup
  • Patent number: 10364426
    Abstract: A process for reducing cell death in eukaryotic and prokaryotic organisms includes the steps of mixing the organisms with water in a first reactor, strobing light onto the mixture of organisms and water for a period of time, passing the strobed mixture into another reactor, and discharging the mixture from the another reactor. The step of strobing light includes strobing light to the mixture of organisms and water at a frequency of between 10 Hz and 40 Hz. The strobing of the light is between twenty flashes per second and eighty flashes per second. The first reactor is a continuously stirred reactor. The another reactor is a plug flow reactor. The organisms are in an algal culture.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: July 30, 2019
    Assignee: MISSING LINK TECHNOLOGY, LLC
    Inventor: Samuel L. Shepherd
  • Patent number: 10350554
    Abstract: A container assembly includes a flexible bag having an interior surface bounding a chamber and an opposing exterior surface, the bag having a bottom end wall being comprised of a first sheet overlying a second sheet, the first sheet and the second sheet of the bottom end wall being welded together so as to form a first sparging area and a separated second sparging area that are both bounded between the first sheet and the second sheet, at least a portion of the first sheet overlying the first and second sparging areas being gas permeable.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: July 16, 2019
    Assignee: Life Technologies Corporation
    Inventors: Michael E. Goodwin, Nephi D. Jones, Derik R. West
  • Patent number: 10342862
    Abstract: The invention relates to an immunization regimen whereby an infant is protected against respiratory syncytial virus (RSV) through administration of a first anti-RSV immune response inducing composition to his or her mother during pregnancy, followed by administration of a second anti-RSV immune response inducing composition to the infant after birth.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: July 9, 2019
    Assignee: GlaxoSmithKline Biologicals, SA
    Inventor: Phillip Dormitzer
  • Patent number: 10316281
    Abstract: A cell culture apparatus includes cell culture units having cell culture chambers, each with at least one manifold. The manifold connects the cell culture unit to a fluid flow channel. The manifold has a dam which allows liquid to pool in the manifold and allows for the creation of an airspace in the manifold, which reduces hydrostatic pressure inside the apparatus and enables the stacking of multiple cell culture units. Embodiments include cascading manifolds, manifolds having reservoirs, and manifolds having valves.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: June 11, 2019
    Assignee: Corning Incorporated
    Inventors: David Alan Kenney, Gregory Roger Martin, Allison Jean Tanner, Joseph Christopher Wall
  • Patent number: 10316298
    Abstract: Methods and compositions for producing fatty acid derivatives, for example, fatty esters, and commercial fuel compositions comprising fatty acid derivatives are described.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: June 11, 2019
    Assignee: REG Life Sciences, LLC
    Inventor: Alfred Gaertner
  • Patent number: 10265392
    Abstract: The present invention pertains to a vaccine comprising non live Lawsonia intracellularis antigen and a pharmaceutically acceptable carrier for use in a method to reduce in a pig the shedding of Lawsonia intracellularis bacteria associated with subclinical infection with Lawsonia intracellularis, by systemic administration of the vaccine to the pig.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: April 23, 2019
    Assignee: Intervet Inc.
    Inventor: Antonius Arnoldus Christiaan Jacobs
  • Patent number: 10238694
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: March 26, 2019
    Assignees: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Patent number: 10214713
    Abstract: The current is directed to a device comprising, a reaction chamber where a reaction takes place, one or more feeding chambers which contain feeding solution comprising chemicals required for the reaction, and one or more porous membranes separating the reaction chamber from the one or more feeding chambers, and wherein the one or more porous membranes are in substantially vertical position. The current invention is also directed to an apparatus comprising a plurality of devices, wherein each device comprises of a reaction chamber where a reaction takes place, one or more feeding chambers which contain feeding solution comprising chemicals required for the reaction, and one or more porous membranes which separate the reaction chamber from feeding chambers, wherein the one or more porous membranes are in substantially vertical position. These devices and apparatuses can be used for high throughput synthesis of biomolecules and chemicals and biological screening assays.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: February 26, 2019
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Zhonghui Hugh Fan, Kirsten Marie Jackson
  • Patent number: 10196609
    Abstract: The present invention provides a composition for promoting cardiac differentiation of a pluripotent stem cell containing an EGFR inhibitor. The present invention also provides a kit for promoting cardiac differentiation containing an EGFR inhibitor and a method for inducing cardiac differentiation of a pluripotent stem cell comprising culturing the pluripotent stem cell in a medium containing an EGFR inhibitor.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: February 5, 2019
    Assignee: KYOTO UNIVERSITY
    Inventors: Norio Nakatsuji, Itsunari Minami
  • Patent number: 10166258
    Abstract: This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and to identify effective growth factors are provided.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: January 1, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Allan B. Dietz, Michael P. Gustafson, Greg W. Butler
  • Patent number: 10151004
    Abstract: A method for specifically detecting and optionally for quantifying Mycobacterium avium ssp. paratuberculosis (MAP) in a sample of an individual is provided. For this purpose, the detection of the presence of the IS900 region in a sample is performed by nucleic acid amplification using specific oligonucleotides. In a further aspect, a test kit for specifically detecting MAP in a sample by amplification methods is also provided. Finally, specific oligonucleotides that are suitable for specifically detecting MAP are described.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: December 11, 2018
    Assignee: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts
    Inventors: Claus-Peter Czerny, Pia Muenster
  • Patent number: 10138284
    Abstract: An insulin analog comprises a B-chain polypeptide containing a cyclohexanylalanine substitution at position B24 and optionally containing additional amino-acid substitutions at positions A8, B28, and/or B29. A proinsulin analog or single-chain insulin analog containing a B domain containing a cyclohexanylalanine substitution at position B24 and optionally containing additional amino-acid substitutions at positions A8, B28, and/or B29. The analog may be an analog of a mammalian insulin, such as human insulin. A nucleic acid encoding such an insulin analog is also provided. A method of lowering the blood sugar of a patient comprises administering a physiologically effective amount of the insulin analog or a physiologically acceptable salt thereof to a patient. A method of semi-synthesis using an unprotected octapeptide by means of modification of an endogenous tryptic site by non-standard amino-acid substitutions.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: November 27, 2018
    Assignee: Case Western Reserve University
    Inventor: Michael A. Weiss
  • Patent number: 10124027
    Abstract: The present invention provides methods of designing panels of bacteriophages as therapeutic compositions against bacterial infections. The present invention also provides panels of bacteriophages for use in the prevention or treatment of bacterial infections.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: November 13, 2018
    Assignee: BIOCONTROL LIMITED
    Inventors: David Harper, Katy Blake
  • Patent number: 10058578
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: August 28, 2018
    Assignees: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Patent number: 10011812
    Abstract: This invention provides a culture control method and a cell culture apparatus that enable stable cell culture by regulating shear stress to be applied to cells within an adequate range. With the application of such culture control method and cell culture apparatus, cell culture is performed under agitation culture conditions in which the shear stress distribution is 0.5 Pa to 20 Pa in 80% or more of the culture vessel by volume.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: July 3, 2018
    Assignee: HITACHI, LTD.
    Inventors: Keisuke Shibuya, Ryoichi Haga, Masaru Namba, Kenichiro Oka, Ken Amano
  • Patent number: 10006055
    Abstract: The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: June 26, 2018
    Assignee: Genomatica, Inc.
    Inventors: Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Jun Sun, Priti Pharkya
  • Patent number: 9938536
    Abstract: Methods and materials for modulating aluminum tolerance in plants are disclosed. For example, nucleic acids encoding aluminum tolerance-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased tolerance to aluminum and methods of increasing plant yield in soil containing elevated levels of aluminum.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: April 10, 2018
    Assignee: Ceres, Inc.
    Inventors: Julissa Sosa, Wuyi Wang
  • Patent number: 9914758
    Abstract: Expression vector systems are provided for increased production of a recombinant GDF-5 (rhGDF-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhGDF-5 protein. Methods for production and high expression of rhGDF-5 protein are disclosed herein. The methods of enhancing production and protein expression of rhGDF-5 protein as disclosed are cost-effective, time-saving and are of manufacturing quality.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: March 13, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: David S. Scher, Roger E. Harrington
  • Patent number: 9896655
    Abstract: The present invention relates compounds for stabilizing cells and methods of their use.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: February 20, 2018
    Assignee: The Scripps Research Institute
    Inventors: Yue Xu, Sheng Ding
  • Patent number: 9879057
    Abstract: Described are methods and products useful for identifying subjects with Mycobacterium avium subspecies paratuberculosis (MAP). A number of protein antigens secreted into culture filtrate by MAP are identified and binding proteins selective for these antigens are demonstrated to be useful for detecting subjects with MAP infections including subjects with Johne's disease.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: January 30, 2018
    Assignee: University of Guelph
    Inventors: Lucy M. Mutharia, Antonio Facciuolo
  • Patent number: 9790464
    Abstract: The present invention relates to a cell culture medium for culturing human cells comprising an anti-coagulated total blood material wherein the hemoglobin level is from about 8 to about 16 g/dl. More particularly, the invention provides a cell culture medium in which cells present in the blood are disrupted and the insoluble remnants of the lysated cells are removed. Further, the invention provides a method for the preparation of a cell culture medium for culturing human cells, according to the invention.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: October 17, 2017
    Assignee: BioMarker Kft.
    Inventors: Henriette Skribek, László Székely
  • Patent number: 9776931
    Abstract: A facility secondary NO3? salinized soil modifier and a modification method are disclosed. The present invention involves the preparation processes of two biological soil modifiers A and B and application methods thereof, which are specifically described as follows: (1) soil modifier A: solid, obtained by microbial fermentation with straw powder and rice bran and the like as raw materials, C/N between 30-50, applied by uniformly mixing at 1-1.4‰ by mass with facility ploughing soil, co-culturing at 35-50° C. for 5-7 days, and then returning to fields; and (2) soil modifier B: liquid, subjected to salt tolerance acclimation to have effective microbial populations, and used in the crop growth period. Based on the microbial techniques, the present invention can improve soil structureness, enhance microbial activity and promote biological immobilization on inorganic nitrogen in soils, significantly increasing the facility cultivation crop yield, and improving the product quality.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: October 3, 2017
    Assignee: Hohai University
    Inventors: Tingting Chang, Xiaohou Shao, Huilian Xu, Weina Wang, Lihua Chen, Xinyu Mao, Chunfang Wang
  • Patent number: 9765294
    Abstract: Chemically defined media for the industrial-scale culture of Bordetella species.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: September 19, 2017
    Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventors: Philippe Marc Helene Dehottay, Philippe Goffin, Filipe Branco dos Santos, Bas Teusink
  • Patent number: 9751930
    Abstract: The present invention provides method for purifying a recombinant protein from a gram-negative bacterial host cell sample or extract thereof wherein said host cell expresses a recombinant protein and a recombinant disulphide isomerase DsbC; comprising: a. adjusting the pH of the host cell sample or extract thereof to a pH of 5 or less to precipitate the recombinant disulphide isomerase; and b. separating precipitated recombinant disulphide isomerase DsbC from the recombinant protein to produce a recombinant protein sample.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: September 5, 2017
    Assignee: UCB PHARMA, S.A.
    Inventor: Gavin Barry Wild
  • Patent number: 9689008
    Abstract: A fermentation method for producing coenzyme Q10 is provided, including stepwisly culturing of microbial strains capable of producing coenzyme Q10, wherein key promoting factors are added in each stage of culture, and in the stage of culture in a fermentor, dissolved oxygen feedback-fed batch culture technique is adopted to realize the feedback regulation of the production of coenzyme Q10, so as to improve the yield of coenzyme Q10.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: June 27, 2017
    Assignees: Inner Mongolia Kingdomway Pharmaceutical Limited, Xiamen Kingdomway Group Company
    Inventors: Yi Wu, Biqin Chen, Guanghuang Zhan, Youpao Zhu
  • Patent number: 9688959
    Abstract: In certain embodiments, this disclosure describes compositions comprising platelet lysates depleted of fibrinogen. In a further embodiment, the composition further comprises a cell culture medium component. This disclosure also provides a method for preparing the composition, comprising the steps of (a) lysing platelets providing a lysate; (b) removing cell debris; and (c) depleting fibrinogen by forming a removable mass by adding a metal salt such as calcium chloride. Furthermore, the disclosure also describes the product produced using said method.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: June 27, 2017
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Ian B. Copland, Jacques Galipeau
  • Patent number: 9676872
    Abstract: The present invention pertains to an affinity tag system for the immobilization and/or purification of molecules such as biological or organic molecules. The invention provides EF-hand subdomains of calcium binding proteins, such as calbindin D9k, as affinity tags and affinity ligands for immobilizing, detecting and/or for purifying molecules, particularly proteins. Also provided are methods utilizing the affinity tag system of the invention, affinity matrices comprising EF-hand subdomain affinity ligands and fusion proteins comprising EF-hand subdomain affinity tags.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: June 13, 2017
    Assignee: Northwestern University
    Inventors: David O'Connell, Sara Linse, Eva Thulin, Alejandro Merino
  • Patent number: 9663804
    Abstract: The present invention relates to the use of glycosyl hydrolase family 61 polypeptides in the presence of cutinases for polyester textile manufacture as well as a textile composition comprising glycosyl hydrolase family 61 polypeptides and cutinases.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: May 30, 2017
    Assignee: Novozymes A/S
    Inventors: Weijian Lai, Ting Sun, Leonardo De Maria
  • Patent number: 9649343
    Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: May 16, 2017
    Assignee: National Institutes of Health (NIH); U.S. Department of Health and Human Services (DHHS); The United States of America, NIH Division of Extramural Inventions and Tehnology Resources (DEITR)
    Inventors: Michael J. Sadowsky, Alexander Khoruts, Alexa R. Weingarden, Matthew J. Hamilton
  • Patent number: 9648813
    Abstract: The invention provides isolated polynucleotides comprising sequences encoding a u ORF peptides and variants and fragments thereof. The invention also provides constructs and vectors containing the polynucleotides. The invention further provides cells, plant cells and plants transformed with the polynucleotides and constructs. The invention also provides methods of using the polynucleotides to control expression of operably linked polynucleotides. The invention also provides methods of manipulating GDP-L-Galactose phosphorylase (GGP) expression and ascorbate production in plants utilizing the polynucleotides of the invention.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: May 16, 2017
    Assignee: The New Zealand Institute for Plant and Food Research Limited
    Inventors: William Alister Laing, Roger Paul Hellens, Richard Colin Macknight, Sean Michael Winsley Bulley
  • Patent number: 9649345
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: May 16, 2017
    Assignees: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Patent number: 9642881
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: May 9, 2017
    Assignees: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Patent number: 9593303
    Abstract: The present invention relates to a method of culturing bacterial organisms belonging to the family Anaplasmataceae in mammalian embryonic or fetal cells. In particular, the present invention is directed to growth of bacterial organisms belonging to the family Anaplasmataceae including organisms belonging to the Anaplasma, Ehrlichia and Neorickettsia genera. The bacterial organisms may be cultured in mammalian embryonic or fetal host cells including feline embryonic host cells. Bacterial material cultured according to the methods described herein may be used as the basis for vaccines against diseases associated with the Anaplasmataceae bacteria, or as the basis for diagnostic applications useful for diagnosing diseases associated with the Anaplasmataceae bacteria.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: March 14, 2017
    Assignee: Intervet Inc.
    Inventors: Jane Kwun-Lai Battles, Kimberly D. Proudfoot, Brenda L. Meding, Patrick G. Funk, R. Monty Warthen, F. Randall Bethke, Eric A. Ellis, Amy Y. Purse
  • Patent number: 9586870
    Abstract: According to the present invention new isolates of bacterial strains have been shown to possess unique properties. These bacterial strains are plant growth-promoting rhizobacterium (PGPR), posses an enhanced competitive advantage at colonizing leguminous plants, and enhance the overall performance of leguminous plant growth. Further still, the present invention discloses a novel method for screening and selecting bacterial strains having the aforementioned beneficial characteristics.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: March 7, 2017
    Assignee: NOVOZYMES BIOLOGICALS, INC.
    Inventors: Yaowei Kang, Shawn Semones, Jessica Smith, Kristi Woods
  • Patent number: 9580488
    Abstract: The present invention provides for fusion tags of 20 to 40 amino acids having a sequence as given in FIG. 1, fusion tags sharing homology with these fusion tags, or hybrid fusion tags comprising sequences of FIG. 1. The invention further provides an expression vector system comprising a fusion tag of the invention, and a process of obtaining recombinant human parathyroid hormone by using the fusion tags and the expression vector system of the invention.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: February 28, 2017
    Inventors: Siddamadappa Chandrashekaran, Venkat Hemalatha
  • Patent number: 9562260
    Abstract: An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent (e.g., an amplification enzyme such as RT). The instrument includes a support structure receiving the test device. A temperature control system maintains the first reaction chamber at a first elevated temperature but simultaneously maintains the second nucleic acid amplification reagent at a second temperature lower than the first temperature so as to preserve the second nucleic acid amplification reagent. An actuator operates on a fluid conduit in the test device to place the first and second reaction chambers in fluid communication with each other after a reaction has occurred in the first reaction chamber at the first temperature.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: February 7, 2017
    Assignee: BIOMERIEUX, INC.
    Inventors: Bryan W. Kluttz, Geoff A. McKinley, Fabio Gennari, Michel Guy, Christopher Cotter, Luigi Catazariti, Louis Graziano, Bruno Colin, Cecile Paris, Jacque Dachaud
  • Patent number: 9540429
    Abstract: Expression vector systems are provided for increased production of a recombinant GDF-5 (rhGDF-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhGDF-5 protein. Methods for production and high expression of rhGDF-5 protein are disclosed herein. The methods of enhancing production and protein expression of rhGDF-5 protein as disclosed are cost-effective, time-saving and are of manufacturing quality.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: January 10, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: David S. Scher, Roger E. Harrington
  • Patent number: 9541477
    Abstract: A medical apparatus and method of preparing one or more cell blocks. The medical apparatus comprises at least one elongate tubular body having a proximal end and a distal end and a filter membrane disposed between the proximal end and a distal end of the elongate tubular body. The filter membrane, which can include alignment features and structural features to engage the tubular body, and/or cover, is sectionable. Additionally, in some embodiments a second elongate tubular body is provided which telescopingly receives at least a portion of the first elongate tubular body. In other embodiments, a support member is provided for engaging the filter membrane and positioning the filter membrane at a midpoint of the elongate tubular body during centrifuging.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: January 10, 2017
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSTITY IN THE CITY OF NEW YORK
    Inventors: Anjali Saqi, Keith Yeager
  • Patent number: 9522938
    Abstract: The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with T lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: December 20, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Martin Wald, Oliver Cromwell, Andreas Nandy, Helga Kahlert, Bernhard Weber, Helmut Fiebig
  • Patent number: 9511080
    Abstract: The present invention provides compositions, methods of manufacture, process and uses for diagnosing, preventing, inhibiting, and treating the development and proliferation of diseases and disorders associated with Okadaella gastrococcus (Og) bacterial infection in a patient.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: December 6, 2016
    Assignee: Okada Medical Services Pty Ltd
    Inventor: Takayuki Okada
  • Patent number: 9506085
    Abstract: A device comprising at least one electrode and at least one cell such as Anabaena variabilis cyanobacteria disposed on said electrode for producing ammonia. A layer of polymer, such as ion exchange polymer, can be used to help immobilize the cells. Whole cells or partially disrupted cells can be used. A method and a system for producing ammonia, comprising contacting at least one cyanobacteria such as Anabaena variabilis cyanobacteria with a media with an electrochemical perturbation is disclosed. The potential enhances ammonia production.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: November 29, 2016
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Johna Leddy, Timothy Michael Paschkewitz
  • Patent number: 9499843
    Abstract: The invention relates to a micro-organism comprising a hydrogenase enzyme system which is capable of converting carbon dioxide into formic acid and a second enzyme system which is capable of converting formic acid into aliphatic carboxylic acids having a chain length of five or more carbon atoms. Also described are various methods for producing oil, as well as other aspects of the invention.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: November 22, 2016
    Assignee: VERDANT BIOPRODUCTS LIMITED
    Inventor: Irene Finnegan
  • Patent number: 9498491
    Abstract: Improved methods for the separation and isolation of bioactive polyelectrolytes, such as humic acid, fulvic acid, ulmic acid, and humin, from any one or a combination of naturally occurring or synthetically produced humified organic matter (HOM) are described. The methods involve the application of an electromagnetic field to an aqueous slurry of the HOM to thereby separate one or more bioactive polyelectrolyte fractions from the remaining of the HOM. Related systems and isolated bioactive polyelectrolyte fractions are also described.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: November 22, 2016
    Assignee: BPW Sciences, LP
    Inventor: Gary W. Black, Sr.
  • Patent number: 9493817
    Abstract: A method for decomposing a target nucleic acid polymer, comprising: bonding a probe nucleic acid polymer and a microparticle to form a probe nucleic acid polymer-bonded microparticle, adding a target nucleic acid polymer to the probe nucleic acid polymer contained within the probe nucleic acid polymer-bonded microparticle to form an addition microparticle, and energizing the microparticle contained within the addition microparticle into a high-energy state and then using energy transfer from this high-energy state microparticle to decompose the target nucleic acid polymer.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: November 15, 2016
    Assignee: Genesis Research Institute, Inc.
    Inventors: Yoshihiro Takeda, Fumitaka Mafune, Tamotsu Kondou
  • Patent number: 9469671
    Abstract: Single-use closed bioreactors with recirculating exhaust gas that can be operated in an uncontrolled environment are reported for the manufacturing of biological products using genetically modified biological cultures that produces carbon dioxide or that requires carbon dioxide in their metabolic process.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: October 18, 2016
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz K. Niazi
  • Patent number: 9447151
    Abstract: There is described a material comprising tapes, ribbons, fibrils or fibers characterized in that each of the ribbons, fibrils or fibers have an antiparallel arrangement of peptides in a ?-sheet tape-like substructure wherein the material comprises a pair of self assembling complementary polypeptides.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: September 20, 2016
    Assignee: The University of Leeds
    Inventors: Neville Boden, Amalia Aggeli, Eileen Ingham, Jennifer Kirkham
  • Patent number: 9422178
    Abstract: The systems and methods described provide for reducing sludge generation, and thus sludge wasting and handling, by including an anaerobic completely stirred tank reactor (CSTR) as a bioreactor in a side-stream. The CSTR provides a significant simplification of side-stream treatment design, enhanced sludge minimization, and enhanced removal of nitrogen and phosphorous without the need to add organic carbon. The described systems and methods provide generation of biogas including both hydrogen and methane from the activated sludge system. The described systems and methods avoid complex reactor designs for nutrient removal.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: August 23, 2016
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Chul Park, Dong-Hyun Chon
  • Patent number: 9403732
    Abstract: The present application relates to systems and methods for processing organic material. The methods may include extraction of biochemical nutrients from organic material, such as food scraps. The method can include comminuting the organic material to form a slurry from components comprising liquid and organic material; combining the slurry with microorganisms, such as a yeast, under aerobic conditions to form a mixture of the slurry and yeast; aerating the mixture; and forming a biomass and a nutrient-rich broth, in which the biochemical nutrients are stabilized and anabolized. The systems may, in some embodiments, be configured to perform the methods of processing organic materials.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: August 2, 2016
    Assignee: WISERG CORPORATION
    Inventors: Larry LeSueur, Jose Lugo, Ken Deering, Victor V. Tryon, Michael Bridges, Lee Wilkerson, Trevor Lewis
  • Patent number: 9387228
    Abstract: To provide a pharmaceutical product or food which has an excellent fat-accumulation-inhibiting activity and/or fat-metabolism-improving activity and which is effective for inhibition or improvement of obesity, fatty liver, etc. The present invention provides an agent for preventing or ameliorating obesity containing, as an active ingredient, cells of a lactic acid bacterium belonging to the genus Pediococcus, a cell culture thereof, or an extract of any of these.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: July 12, 2016
    Assignee: HIROSHIMA UNIVERSITY
    Inventors: Masanori Sugiyama, Fumiko Higashikawa, Masafumi Noda