Including Liquid Dispenser Means Patents (Class 435/286.4)
-
Patent number: 12055467Abstract: The invention relates to an apparatus (1) for producing a wax block containing a tissue sample (1), comprising: a container (4) into which the tissue sample (1) is placed; and a dispensing apparatus (10) for dispensing different substances (8) into the container (4). The apparatus (1) according to the present invention is notable for the fact that it comprises an emptying device (23) for emptying the container (4); and a control unit (22) is provided, which is designed to apply control to the dispensing apparatus (10) and to the emptying device (23) in such a way that in several successive cycles, at least one of the substances is respectively dispensed into the container (4) and the container (4) is emptied again after a specific time period.Type: GrantFiled: July 24, 2018Date of Patent: August 6, 2024Assignee: Leica Biosystems Nussloch GmbHInventor: Thomas Märsch
-
Patent number: 11958051Abstract: An incubation cassette for reducing liquid evaporation from wells of a microplate that has a frame for receiving a microplate having wells. The frame has a central first opening that is surrounded by an inner wall and the dimensions are designed for the placement of the microplate therein, and an outer wall extends substantially parallel to the inner wall and adjoins the inner wall via an intermediate bottom such that a liquid reservoir for holding a liquid is formed by the two walls and the intermediate bottom, the liquid reservoir surrounding the first central opening. At least a portion of the incubation cassette that forms the liquid reservoir is provided at least in part with at least one transparent portion (TA).Type: GrantFiled: December 17, 2020Date of Patent: April 16, 2024Assignee: TECAN TRADING AGInventors: Manfred Lansing, Tobias Sawetzki, Nicole Eggenhofer
-
Patent number: 11667947Abstract: Described herein are methods and systems for identifying a composition having anti-pathogenic activity; evaluating the anti-pathogenic activity of a composition; measuring the metabolic function of a pathogen; and/or comparing the anti-pathogenic performance of a plurality of compositions.Type: GrantFiled: December 5, 2019Date of Patent: June 6, 2023Assignee: Colgate-Palmolive CompanyInventors: Ekta Makwana, Carlo Daep
-
Patent number: 11262372Abstract: Work, such as status confirmation, in a plurality of automatic analyzers is efficiently performed. In an automated analysis system, a tablet terminal 114 has a terminal information management unit 210 and a terminal display unit 208. A terminal information management unit 210 acquires device information showing the state status of a device from automatic analyzers 101a to 101d, and generates a status confirmation screen showing the device status of the automatic analyzer. A terminal display unit 208 displays the status confirmation screen. The status confirmation screen has a status information screen showing the device status of one automatic analyzer and a device switch button configured to switch the status information screen to a status information screen corresponding to another other automatic analyzer.Type: GrantFiled: February 27, 2018Date of Patent: March 1, 2022Assignee: Hitachi High-Tech CorporationInventors: Satoshi Shibuya, Toshihide Hanawa, Mikio Kasama
-
Patent number: 11208624Abstract: A device for centering of petri dishes, where the petri dishes include a bottom container with a lateral surface and a lid with a lid diameter, including an elevator with an elevator axis and an elevator drive, and the conveyor includes concentrically along the elevator axis a frustoconical through-hole tapering downwards, and the elevator drive is built to move a substantially flat plate from a neutral position downwards into a first position, which is reached as soon as the petri dish rests with its weight on the inner surface of the through-hole, and the elevator drive is built to rotate the plate during a movement of the plate from the neutral position into the first position.Type: GrantFiled: March 13, 2017Date of Patent: December 28, 2021Assignee: CLEVER CULTURE SYSTEMS, AGInventors: Alexander Bohm, Nedim Bogilovic, Wolfgang Stiegmaier
-
Patent number: 11078035Abstract: An apparatus for dispensing microorganism culture plates, culture plate loader and culture plate reader comprising the same, as well as method dispensing microorganism culture plates, method of loading such culture plates into a culture plate reader, and method of counting microorganism colonies on such culture plates.Type: GrantFiled: November 22, 2016Date of Patent: August 3, 2021Assignee: 3M INNOVATIVE PROPERTIES COMPANYInventor: Phillip A. Bolea
-
Patent number: 10995313Abstract: The invention relates to a liquid supply interface for a cell culture system for supplying cell cultures found in different cell culture containers with a nutrient medium, wherein the liquid supply interface comprises: a housing defining a flow area; a first connection formation for the liquid-transferring connection of a first fluid line to the housing; a second connection formation formed separately from the first for the liquid-transferring connection of a second fluid line to the housing; a third connection formation formed separately from the first two for the liquid-transferring connection of the housing to a third fluid line; a coupling formation formed separately from the connection formations, which is formed for the producible and detachable liquid-transferring coupling contact according to the operation, with a corresponding counter-coupling formation of a cell culture container.Type: GrantFiled: August 31, 2018Date of Patent: May 4, 2021Assignee: Hamilton Bonaduz AGInventors: Thomas Jäger, Dirk Schlenker, Nabih Othman, Oliver Kühne
-
Patent number: 10736261Abstract: The tree planting machine includes a vehicle main unit, a washing water tank, a planting device, a washing water circuit, and a controller. The washing water tank is attached to the vehicle main body and holds water. The planting device is disposed on the vehicle main unit. The washing water circuit connects the washing water tank and the planting devices. The controller controls the washing water circuit so as to supply the water from the washing water tank to the planting devices.Type: GrantFiled: July 25, 2018Date of Patent: August 11, 2020Assignee: KOMATSU LTD.Inventors: Hirokazu Asaka, Yudai Furudate
-
Patent number: 10677727Abstract: A system for measuring a liquid sample comprising biological material, the system comprising an integrating light collector for collecting light and for at least partially containing the sample; a light source for introducing light in the integrating light collector; a signal generator or modulator configured to cause a known modulation of the light output by the light source; a phase-sensitive detector for detecting scattered light in the integrating light collector; at least one of an exit port to allow un-scattered light to exit the integrating light collector, a beam dump, or a baffle arranged to absorb unscattered light; and a processor configured to analyse the detected modulated light to determine changes in the detected modulated light as a function of time thereby to determine at least one of: drug susceptibility of the biological material; a change in a number of cells in the sample; a change in cell state; a change in the biological material.Type: GrantFiled: August 7, 2018Date of Patent: June 9, 2020Assignee: University Court of the University of St AndrewsInventors: Robert J H Hammond, Mario E. Giardini, Stephen H. Gillespie
-
Patent number: 10435660Abstract: A fluid line element for building a fluid line section comprising a plurality of identical fluid line elements, wherein the fluid line element comprises: —an element body, —a first throughflow opening provided on the element body and a second throughflow opening, different from the first, —and a flow channel provided in the element body, which fluidically connects the first and the second throughflow openings for throughflow along a channel path. In a first region of the fluid line element, located closer to the first than to the second throughflow opening, a throughflow body formed separately from the element body is provided, which —forms a part of the flow channel, —is formed from a material having a lower elasticity modulus than the material of the element body, and —on the longitudinal end thereof facing into the interior of the element body, comprises a valve seat formation surrounding the channel path.Type: GrantFiled: June 3, 2015Date of Patent: October 8, 2019Assignee: Hamilton Bonaduz AGInventors: Tobias Seiler, Oliver Kühne, Carsten Etzold
-
Patent number: 10416177Abstract: The invention provides for an analysis system (100, 300, 400) for analyzing a biological sample (108) comprising an analyzer (102) with an analytical unit (106) for analyzing the biological sample to obtain an analysis result (140). The analyzer is configured for receiving a cartridge (110) comprising an identifier (114) and containing at least one reagent for analyzing the biological sample. The analyzer comprises an identification unit (116) for reading the identifier. The analyzer accepts the cartridge if the identifier is valid. The analysis system further comprises a protocol creation system (150, 104).Type: GrantFiled: April 3, 2014Date of Patent: September 17, 2019Assignee: Roche Molecular Systems, Inc.Inventors: Paul Frank, Christopher Newhouse, Sascha Roehrig
-
Patent number: 10283220Abstract: A system and method of coordinated motion among heterogeneous devices includes a medical device with one or more movable elements and one or more processors. Any of the processors uses a shared interface to access services. The medical device requests a movement token from a token service through the shared interface, receive the movement token from the token service, exchange configuration data, kinematic data, or planned motion data through the shared interface, plan a first motion for a first movable element of the movable elements based on the movement token and the configuration data, the kinematic data, or the planned motion data, and execute the first motion. In some embodiments, the movement token is selected from a group consisting of an exclusive-motion token, a master follow-me token, a slave follow-me token, a master collision-avoidance token, a slave collision-avoidance token, and a passive collision-avoidance token.Type: GrantFiled: August 14, 2014Date of Patent: May 7, 2019Assignee: INTUITIVE SURGICAL OPERATIONS, INC.Inventors: Mahdi Azizian, Jonathan M. Sorger, Simon P. Dimaio
-
Patent number: 10274403Abstract: The application discloses a device for drawing a liquid from a process tank to be protected from contamination, including: a first receptacle for receiving the liquid withdrawn from the process tank; a first liquid line connecting the process tank with the first receptacle; and at least one first valve assembly disposed in the first liquid line and designed to block or release liquid transport through the first liquid line. The device includes at least one pressure sensor for detecting a pressure within the first receptacle. The device is designed such that a pressure difference between the first and the second ends of the first liquid line is greater than a predetermined minimum value when the first liquid line is connected with the process tank and the process tank is to be protected from contamination.Type: GrantFiled: October 1, 2018Date of Patent: April 30, 2019Assignee: Endress+Hauser Conducta GmbH+Co. KGInventors: Angela Eubisch, Thomas Höhne, Melanie Müller, Thomas Steckenreiter, Michael Hanko
-
Patent number: 10274943Abstract: A control system for controlling transport devices includes a first server that has a first storage unit and a first instruction unit, and a second server that has a second storage unit and a second instruction unit. In a first state, the first storage unit transmits first transport information to the first instruction unit, the first instruction unit transmits second transport information to a target transport device, and instruction unit information is stored in common in the first instruction unit and the second instruction unit. If the first instruction unit stops operating normally in the first state, the control state is switched to a second state, and in the second state, the first storage unit transmits the first transport information to the second instruction unit, and the second instruction unit transmits the second transport information to the target transport device based on the instruction unit information.Type: GrantFiled: February 8, 2018Date of Patent: April 30, 2019Assignee: Daifuku Co., Ltd.Inventors: Masahiro Takahara, Tomoaki Nishikawa, Tsuyoshi Uemura
-
Patent number: 9618733Abstract: An imaging assembly for the viewing, imaging, and analysis of chemiluminescent or bioluminescent samples in gels or other substrates, in which an adjustable camera and lens module having a prime or fixed lens or a focusing lens is moved to change the field of view by shifting the focal plane of the camera and lens module. The imaging assembly can also include a mirror to bend or fold the optical path between the camera and lens module and the target area having a sample, in which the mirror can move in the same vertical direction as the camera and lens module. Further, the camera and lens module can be configured to more move in a diagonal direction relative to the location of the imaging target area. The imaging assembly can further have a duct system adaptable to adjust with the movement of the camera and lens module.Type: GrantFiled: July 28, 2014Date of Patent: April 11, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Steve Swihart, Evan Thrush, Evelio Perez, Kevin McDonald
-
Patent number: 9530053Abstract: A method of detecting an original arrangement of laboratory articles of a laboratory work station records reference digital images with a digital camera. An image is displayed and visible regions with characteristic features are selected by a user within an input device. Reference image sections and corresponding reference image parameter files are produced and stored. A current arrangement of laboratory articles is compared with a previously recorded original arrangement. Detection of the current arrangement occurred by recording current digital images with a digital camera and creating current image sections defined by X/Y parameters of the reference image parameter files from the current digital images. A computer-based comparison of the processed current image sections with the processed reference image sections occurred and an analysis of this comparison and the display of agreements, deviations and errors is found.Type: GrantFiled: July 30, 2013Date of Patent: December 27, 2016Assignee: Tecan Trading AGInventors: Simon M. Eckard, Nikolaus Ingenhoven
-
Patent number: 9399244Abstract: A cleaning device for a laboratory fermenter for growing microorganisms is provided. The laboratory fermenter to be cleaned has a gas supply connection connected to a line reaching into the fermenter's nutrient solution, an exhaust connection to the gas space over the nutrient solution, and a withdrawal connection leading to the fermenter's deepest point. The cleaning device includes three cleaning connections, an immersion pipe connection and two gas connections. Flow in each gas connection is controlled via intermediate switch valves having a cleaning start position and a cleaning end position. The cleaning connections are connected via hose lines to hose pinch control valves, a hose pinch pump, at least one filter. A cleaning control manages the cleaning process by controlling flow from and/or to an air connection, a water connection and a waste water connection. The cleaning controller may also control introduction of acids and/or bases.Type: GrantFiled: May 16, 2013Date of Patent: July 26, 2016Assignee: Infors AGInventors: Dieter Cueni, Daniel Egger
-
Patent number: 9212344Abstract: Provided is a small-scale cell culture apparatus having a culture medium replacement function for culturing cells in a small number of Petri dishes, the cell culture apparatus being capable of performing automatic replacement of the culture medium and cell culture within the same cavity and significantly reducing the apparatus cost. At least one set of upper and lower discs is arranged inside an incubator chamber 1. Petri dishes 4, 6 in each of which cells and a culture medium are put are held on lower discs 18, 19, and top lids 5, 7 are held on upper discs 19, 30. The lower side of each of the top lids is open.Type: GrantFiled: February 28, 2013Date of Patent: December 15, 2015Assignee: JTEC CORPORATIONInventors: Takashi Tsumura, Takahiro Ono
-
Patent number: 9131666Abstract: A hatching egg inspection apparatus includes a loader unit, an inspection unit for determining the viability or the like as to whether a hatching egg is an unfertilized egg or a growth-stopping egg, a rejection unit for rejecting a hatching egg determined to be an unfertilized egg or the like, and an unloader unit for sending a hatching egg toward the next step. The inspection unit is provided with a light emitting unit for emitting prescribed light toward the hatching egg, a cap attachment unit through which the light having been emitted to the hatching egg and having transmitted through the hatching egg passes, and a light receiving unit for receiving the light that has passed through the cap attachment unit. The cap attachment unit includes a cylindrical cap coming into contact with the hatching egg, and a plate to which the cap is attached.Type: GrantFiled: May 18, 2012Date of Patent: September 15, 2015Assignees: Yamamoto Corp., Nabel Co., Ltd.Inventors: Mitsuo Yamamoto, Tsuyoshi Yamamoto, Shinichi Fujitani, Takatsugu Tahara, Toyoaki Ohashi
-
Patent number: 9045723Abstract: The disclosure relates to a device for dispensing a prescribed material into a Petri dish, each Petri dish including a removable lid capable of being arranged on a bottom that is not as broad as the latter, bringing the Petri dish to a material-dispensing station. According to the disclosure, the device includes a piston comprising a plate for supporting the bottom at the material-dispensing station and a device for rotating the plate on itself relative to the dispensing head, arranged so as to rotate the bottom relative to dispensing head in the position for dispensing the material into the bottom, in which the material outlet tip is arranged relative to plate in order to dispense the material into the rotated bottom.Type: GrantFiled: July 30, 2010Date of Patent: June 2, 2015Assignee: AES CHEMUNEXInventor: Nicolas Brelivet
-
Patent number: 9040284Abstract: Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (1), sample carrier temperature regulation systems (60), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments.Type: GrantFiled: September 24, 2012Date of Patent: May 26, 2015Assignee: DAKO DENMARK A/SInventors: Kristopher Buchanan, Marc Key, John Favuzzi, Rosanne Welcher, Benno Guggenheimer, Robert Clark, Michael Barber, Bob Lathrop
-
Patent number: 9017993Abstract: An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermocycling subsystem, in automated fashion. The ePCR subsystem can continuously thermocycle an inverse emulsion passed therethrough and includes static temperature zones and a consumable thermocycling plate. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion.Type: GrantFiled: April 9, 2012Date of Patent: April 28, 2015Assignee: Life Technologies CorporationInventors: Jonathan Schultz, John Nobile, Brian Reed, Prasanna Thwar, Todd Roswech
-
Patent number: 8956580Abstract: An analysis cartridge comprising a cartridge body, a first cover, a liquid storage box and a sealing film is disclosed. The cartridge body has an accommodation portion and a first side and a second side opposite to the first side. The first cover covers the first side or the second side of the cartridge body and has a first through hole. The liquid storage box is disposed in the accommodation portion and has a liquid through hole. The sealing film seals the liquid through hole of the said liquid storage box and passes through the first through hole of the first cover, wherein the liquid through hole is exposed by removing the sealing film.Type: GrantFiled: January 14, 2013Date of Patent: February 17, 2015Assignee: Lite-On Technology CorporationInventors: Cheng-Chang Lai, Fu-Chun Huang, Yuh-Jiuan Lin
-
Patent number: 8926903Abstract: To perform accurate measurement in the analysis of chemical components with low concentration, pretreatment such as concentration and purification of samples is essential. For high-throughput of pretreatment of biological samples, various random clinical testing is encountered, where analytes change from sample to sample. The pretreatment apparatus has a separating agent selectively separating a specific component by allowing a sample solution to flow therethrough. A holding section holds a plurality of housing sections, which house the separating agent therein, and has an endless track. A pressurizing section applies pressure to the housing section in a continuous and random-accessible manner; and an extraction solution receiver mechanism selectively receives an extracted solution from the separating agent housed in the housing section. A mass spectrometer is that can be connected to the pretreatment apparatus. Thus, a large number of specimens can be simultaneously processed.Type: GrantFiled: July 8, 2009Date of Patent: January 6, 2015Assignee: Hitachi High-Technologies CorporationInventors: Makoto Nogami, Katsuhiro Kanda, Izumi Waki
-
Patent number: 8927258Abstract: An integrated device for diagnostic analyzes used to verify the presence of bacteria in at least a biological sample mixed with a eugonic culture medium in liquid form, to classify at least the type of bacteria, and to test a series of antibiotics, selected from a group of characteristic antibiotics at least for the type of bacteria identified, identifying those effective to determine the antibiotic therapy. The device comprises, inside an integrated structure, first containing means provided with containing elements in which the biological samples to be analyzed are distributed, second containing means comprising recipients or micro-plates thermostated with wells containing a eugonic culture medium in liquid form in which a first fraction of the biological samples to be analyzed is dispensed, and a first recipient and second recipients or plates with a relative first well and second wells in which a further fraction of the biological samples which resulted positive to the analysis is dispensed.Type: GrantFiled: February 24, 2010Date of Patent: January 6, 2015Assignee: Alifax Holding SpAInventors: Paolo Galiano, Gian Piero Spezzotti
-
Patent number: 8895291Abstract: Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.Type: GrantFiled: October 7, 2011Date of Patent: November 25, 2014Assignee: Terumo BCT, Inc.Inventors: Thomas G. Dilorenzo, Edward Allan Stanton, IV, Glen Delbert Antwiler, Michael E. Kinzie, Brian J. Nankervis, Monique Givens, Casey V. Medina, Jon A. Dodd
-
Patent number: 8892254Abstract: A robot controller includes queues, a storage unit, and an execution control unit. The queues are provided for respective controlled groups serving as controlled units. The storage unit stores therein instructions directed to the respective controlled groups, one at a time, from a bottom end of each of the queues. When having accepted a predetermined operation request, the execution control unit simultaneously fetches the instructions directed to the controlled groups, one for each of the controlled groups at a time, from tops of the queues, and makes all of the controlled groups simultaneously start the operations based on such instructions. If there is any controlled group to which no corresponding instruction exists, the storage unit stores therein a no-operation instruction. If the fetched instruction is the no-operation instruction, the execution control unit keeps the controlled group from operating until an instruction is fetched next time.Type: GrantFiled: February 5, 2013Date of Patent: November 18, 2014Assignee: Kabushiki Kaisha Yaskawa DenkiInventor: Takahiro Maeda
-
Patent number: 8859263Abstract: The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.Type: GrantFiled: August 7, 2012Date of Patent: October 14, 2014Assignee: University of PittsburghInventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
-
Patent number: 8758678Abstract: A machine for producing and dispensing liquid and semi-liquid consumer food products such as ice creams, whipped cream, yogurt and the like comprises a container for a basic product of the consumer food product, a feed and treatment circuit for the basic product, comprising a feed pump, dispensing means positioned at an outfeed end of the feed and treatment circuit, and a device for checking the bacterial load of the product during production/dispensing; an electronic control unit controlling and regulating the various steps for measuring the bacterial load.Type: GrantFiled: March 12, 2008Date of Patent: June 24, 2014Assignee: Ali S.p.A.Inventors: Gino Cocchi, Roberto Lazzarini, Gianni Zaniboni
-
Patent number: 8759079Abstract: An apparatus for automatically analyzing a nucleic acid includes: a sample preprocessing device including a plurality of chambers in which reagents mixed with a sample are accommodated according to sample preprocessing process order for extracting a nucleic acid from the sample; and a nucleic amplifying and detecting device connected with the sample preprocessing device to receive the nucleic acid extracted from the sample.Type: GrantFiled: December 8, 2011Date of Patent: June 24, 2014Assignee: Korea Institute of Machinery & MaterialsInventor: Oh Won Kwon
-
Patent number: 8709825Abstract: A nozzle for use in a flow cytometer and a method of orienting particles with a baffle disposed within a nozzle. The baffle may be a baffle plate positioned in a fluid flow path to deflect a fluid stream and to orient particles in a desired orientation as they exit the nozzle.Type: GrantFiled: March 1, 2013Date of Patent: April 29, 2014Assignee: Inguran, LLCInventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
-
Patent number: 8679838Abstract: It is intended to provide a serum which contains a large amount of growth factors capable of efficiently promoting the growth of stem cells. A human serum for cell culture which shows a residual ratio of platelets remaining within 20 minutes after blood collection in relation to the whole amount of the platelets is 0% to 20%, and a release ratio of cell growth factors is 20% to 100%.Type: GrantFiled: February 12, 2010Date of Patent: March 25, 2014Assignee: JMS Co., Ltd.Inventors: Koji Suzuki, Seishin Tanaka
-
Patent number: 8664006Abstract: A nozzle system for use in a flow cytometer for analyzing particles in a fluid stream and a method of orienting particles in a flow cytometer. The nozzle system may include a nozzle having a longitudinal axis, an interior surface defining a fluid flow path for orienting particles in the nozzle, and a downstream orifice through which a fluid stream exits. The nozzle system may also include a conduit positioned to introduce a core stream containing particles at a location offset from the longitudinal axis and a baffle downstream of the conduit to deflect the fluid stream. The method may include the steps of causing a sheath fluid to flow through the nozzle, introducing a core fluid stream into the sheath fluid at a location offset to the longitudinal axis of the nozzle, and deflecting the core fluid stream with a baffle.Type: GrantFiled: March 1, 2013Date of Patent: March 4, 2014Assignee: Inguran, LLCInventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
-
Patent number: 8663978Abstract: The present invention concerns an apparatus for staining tissue samples, said apparatus including a reagent section or reagent containers; at least one staining section or tissue samples, a robotic head or robotic element that may move reagent to a predetermined tissue sample, said robotic element being moveable above the reagent and the staining sections, a control element that may manage a staining process, a 2-D optical sensor to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element. By providing the robotic element with a 2-D optical sensor, a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus.Type: GrantFiled: August 6, 2012Date of Patent: March 4, 2014Assignee: Dako Denmark A/SInventors: Doug Sweet, Marc Key, Gordon Feingold, Kristopher Buchanan, Bob Lathrop, John Favuzzi
-
Publication number: 20140051083Abstract: The invention relates to an automatic response/light measurement device and a method therefor, and the purpose is to effectively and quickly perform an optical measurement relating to a reaction with high reliability without increasing a device size.Type: ApplicationFiled: February 6, 2012Publication date: February 20, 2014Applicant: Universal Bio Research Co., Ltd.Inventor: Hideji Tajima
-
Publication number: 20130316336Abstract: Provided is an analyzer capable of reducing the amount of wasted reagents and shortening time required for solution sending, thus increasing throughput for analysis. A microsyringe sucks a minimum required amount of reagent that is substantially the same amount of capacity of a flow cell to a sampling nozzle. Then, the sampling nozzle is inserted into an injection port of the flow cell, and the reagent is injected into the flow cell by driving the microsyringe. The inside of the sampling nozzle is cleaned by moving the sampling nozzle to the cleaning tank and ejecting cleaning water from the sampling nozzle, and the outside of the sampling nozzle is cleaned by spraying cleaning water from an inner wall of the cleaning tank.Type: ApplicationFiled: January 13, 2012Publication date: November 28, 2013Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Takuya Matsui, Ryoji Inaba, Kazumichi Imai, Ryusuke Kimura
-
Patent number: 8554372Abstract: A method of managing resources of a histological tissue processor, the tissue processor comprising at least one retort (12, 14) selectively connected for fluid communication to at least one of a plurality of reagent resources (26) by a valve mechanism (40), the method comprising the step of: nominating resources according to one of: group, where a group nomination corresponds to a resource's function; type, where a type nomination corresponds to one or more attributes of a resource within a group; station, where a station nomination corresponds to a point of supply of a resource.Type: GrantFiled: September 29, 2004Date of Patent: October 8, 2013Assignee: Leica Biosystems Melbourne Pty LtdInventors: Victor Camfield Windeyer, Michael Houston Drummond
-
Patent number: 8486349Abstract: A microfluidic-based flow assay and methods of manufacturing the same are provided. Specifically, the microfluidic flow assay includes a micropatterned surface that induces clot formation and an array of microfluidic channels though which blood flows. The micropatterned surface contains two clotting stimuli, one for inducing platelet adhesion and another for inducing the coagulation cascade.Type: GrantFiled: March 10, 2011Date of Patent: July 16, 2013Assignee: Colorado School of MinesInventors: Keith Benjamin Neeves, Ryan R. Hansen
-
Patent number: 8489337Abstract: Certain embodiments disclosed herein include, but are not limited to, at least one of compositions, methods, devices, systems, kits, or products regarding rejuvenation or preservation of germ cells or gametes. Certain embodiments disclosed herein include, but are not limited to, methods of modifying germ cells or gametes, or methods of administering modified germ cells or gametes to at least one biological tissue.Type: GrantFiled: June 24, 2010Date of Patent: July 16, 2013Assignee: The Invention Science Fund I, LLCInventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
-
Patent number: 8481302Abstract: A system for measuring total microbiological content in an aqueous medium by adding a fluorescent dye to the aqueous medium, measuring the fluorescent signal in the aqueous medium to obtain a baseline fluorescent signal, releasing intracellular content of the microbiological matter into the aqueous medium by lysing the microbiological matter. The system then measures the fluorescent signal in the aqueous medium with the released intracellular content of the microbiological matter to obtain a second fluorescent signal. Next, the system subtracts the baseline signal from the second fluorescent signal to obtain a net fluorescent signal and equates the net fluorescent signal with a microbiological content.Type: GrantFiled: May 26, 2009Date of Patent: July 9, 2013Assignee: General Electric CompanyInventors: Scott M. Boyette, Hong Cai, Yan Jin, Jie Li, Kechao Yang, Rong Xu, Yu Wang
-
Patent number: 8445261Abstract: An apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises an imaging mechanism for automatically determining the state of an individual cell of the cells over time. The imaging mechanism is in communication with the incubating mechanism.Type: GrantFiled: January 7, 2011Date of Patent: May 21, 2013Assignee: University of PittsburghInventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
-
Publication number: 20130095566Abstract: Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium; calculating metabolic flux reorganization in various environments and at various growth rates; and calculating the maximum metabolic rate and optimal metabolite concentrations and enzyme activities by applying a computational optimization method to a kinetic model of a metabolic pathway. The optimization methods use intracellular molecular crowding parameters and/or well as kinetic rates to assist in modeling metabolic activity.Type: ApplicationFiled: September 28, 2012Publication date: April 18, 2013Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventor: University of Pittsburgh - Of the Commonwealth
-
Publication number: 20130095469Abstract: An apparatus for dispensing one or more cells or particles confined in a free flying droplet has a droplet generating device configured to eject out of an orifice a free flying droplet of a suspension of cells or particles. The droplet generating device has a branch-less one-way channel having the orifice at one end thereof. A device for detecting information on cells or particles located in an observation volume of the suspension within the branch-less one-way channel is provided. An ejected droplet is directed to a first position or a second position depending on the detected information.Type: ApplicationFiled: December 6, 2012Publication date: April 18, 2013Applicant: ALBERT-LUDWIGS-UNIVERSITAET FREIBURGInventor: ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
-
Patent number: 8420025Abstract: Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation.Type: GrantFiled: January 26, 2012Date of Patent: April 16, 2013Assignee: General Electric CompanyInventors: Radislav A. Potyrailo, Prashant V. Shrikhande, Scott M. Boyette, Caibin Xiao, Andrew M. Leach
-
Patent number: 8389272Abstract: A method and apparatus for delivering one or more fluids. Fluids may be delivered sequentially from a common vessel to a chemical, biological or biochemical process.Type: GrantFiled: September 6, 2011Date of Patent: March 5, 2013Assignee: President and Fellows of Harvard CollegeInventors: Vincent Linder, Samuel K. Sia, George M. Whitesides
-
Patent number: 8367398Abstract: Provided is a microfluidic apparatus including: a microfluidic structure for providing spaces for receiving a fluid and for forming channels, through which the fluid flows; and valves for controlling the flow of fluid through the channels in the microfluidic apparatus. The microfluidic structure includes: a sample chamber; a sample separation unit receiving the sample from the sample chamber and separating a supernatant from the sample by using a centrifugal force; a testing unit receiving the supernatant from the sample separation unit for detecting a specimen from the supernatant using an antigen-antibody reaction, and a quality control chamber for identifying reliability of the test.Type: GrantFiled: September 29, 2009Date of Patent: February 5, 2013Assignee: Samsung Electronics Co., Ltd.Inventors: Beom Seok Lee, Ji Won Kim, Jeong Gun Lee, Kui Hyun Kim
-
Patent number: 8343778Abstract: The invention encompasses microfluidic microarray assemblies (MMA) and subassemblies and methods for their manufacture and use. In one embodiment, first and second channel plates are provided and are sealingly connected to a test chip in consecutive steps. Each plate includes microfluidic channels configured in a predetermined reagent distribution pattern. The test chip comprises a plurality of discrete test positions, each test position being located at the intersection between a first predetermined reagent pattern and a second predetermined reagent pattern, wherein at least one of said patterns is non-linear. The first channel plate allows the distribution of a first reagent on said test chip, wherein said first reagent is immobilized at said test positions. The second channel plate allows the distribution of a second reagent on said test chip, wherein said second reagent comprises a plurality of different test samples.Type: GrantFiled: December 12, 2005Date of Patent: January 1, 2013Assignee: Simon Fraser UniversityInventors: Hua Zhong Yu, Meenakshinathan Parameswaren, Paul Chi Hang Li, Xing Yue Peng, Hong Chen, Wa Lok Chou
-
Patent number: 8293521Abstract: It is intended to easily dispense a minute amount of nonvolatile liquid. In a preferred embodiment, in dispensing of mineral oil (nonvolatile liquid), dispensing is conducted in the condition that the amount of air contained in a tip (70) is small by aspirating a larger amount of mineral oil (40) than a single dispensing amount in the tip (70) of a nozzle (28).Type: GrantFiled: March 30, 2006Date of Patent: October 23, 2012Assignees: Shimadzu Corporation, Toppan Printing Co., Ltd., RikenInventors: Nobuhiro Hanafusa, Koretsugu Ogata, Ryuh Konoshita, Yusuke Nakamura, Yozo Ohnishi
-
Patent number: 8282896Abstract: Carriers or holders for holding microfluidic devices are provided. Some of the carriers that are provided include a hydration control device and/or a source of controlled fluid pressure to facilitate use of the carrier in conducting various types of analyses.Type: GrantFiled: October 5, 2009Date of Patent: October 9, 2012Assignee: Fluidigm CorporationInventors: Geoffrey Richard Facer, Hany Ramaz Nassef
-
Patent number: 8257968Abstract: The present invention concerns an apparatus (1) for staining tissue samples, said apparatus (1) including a reagent section (2) or reagent containers (3); at least one staining section or tissue samples, a robotic head (22) or robotic element (20) that may move reagent to a predetermined tissue sample, said robotic element (20) being moveable above the reagent and the staining sections, a control element (85) that may manage a staining process, a 2-D optical sensor (86) to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element (86). By providing the robotic element (20) with a 2-D optical sensor (86), a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus.Type: GrantFiled: December 19, 2003Date of Patent: September 4, 2012Assignee: DAKO Denmark A/SInventors: Doug Sweet, Marc Key, Gordon Feingold, Kristopher S. Buchanan, Bob Lathrop, John Favuzzi