Including A Coated Reagent Or Sample Layer Patents (Class 435/287.9)
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Patent number: 8703061Abstract: The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as an integrated modular unit and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. The integrated modular unit includes an analyte-concentrator-microreaction device connected to a modified cartridge-cassette.Type: GrantFiled: June 4, 2012Date of Patent: April 22, 2014Assignee: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Patent number: 8703504Abstract: A lateral flow, membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes phosphorescence to detect the signals generated by excited phosphorescent labels. The labels may have a long emission lifetime so that background interference from many sources, such as scattered light and autofluorescence, is practically eliminated during detection. In addition, the phosphorescent labels may be encapsulated within particles to shield the labels from quenchers, such as oxygen or water, which might disrupt the phosphorescent signal.Type: GrantFiled: September 4, 2013Date of Patent: April 22, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventor: Xuedong Song
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Patent number: 8697434Abstract: A phage specific antibody presenting particle, devices and methods related to detection of phage amplification are provided.Type: GrantFiled: January 9, 2009Date of Patent: April 15, 2014Assignee: Colorado School of MinesInventor: Kent J. Voorhees
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Publication number: 20140099704Abstract: A blood coagulation time measuring sensor comprising a surface, a resin layer applied thereto, including at least one substance with a detection function, characterized in that the resin layer comprises a lacquer system, wherein said lacquer system i) is suitable for immobilization of the at least one substance with a detection function on the surface; and ii) provides a negatively charged surface layer; iii) and allows the replacement of biological blood coagulation promoters by non-biological chemically inert and stable compounds.Type: ApplicationFiled: May 4, 2012Publication date: April 10, 2014Applicant: The Swatch Group Research and Development Ltd.Inventors: Wolfgang Schuhmann, Erik Jan Frenkel
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Publication number: 20140099703Abstract: A cuvette for use with a spectophotometer having a capillary sample chamber having a volume of from 1 microliter to 1 femtoliter.Type: ApplicationFiled: October 5, 2012Publication date: April 10, 2014Inventor: William P Parker
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Patent number: 8685745Abstract: A multilayered optical sensing patch, for the measurement of conditions, such as pH, oxygen level, etc, within containers, is provided. The multilayered optical sensing patch of the present invention is comprised of a heat sealable polymer substrate layer, and a polymeric sensing membrane later attached thereto. The polymer sensing membrane layer is formed of a porous polymer support membrane, and an optical sensing composition (comprising a reactive indicator) covalently bonded thereto. The heat sealable polymer substrate layer is capable of being securely bonded to the inner layer of bioreactor bags, as well as the porous polymer support substrate layer. Further, the porous polymer support membrane layer provides a firm supporting structure for the polymeric sensing layer, thereby protecting the optical sensing composition disposed therein from degradation/damage.Type: GrantFiled: October 26, 2011Date of Patent: April 1, 2014Assignee: Polestar Technologies, Inc.Inventor: James A. Kane
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Patent number: 8685713Abstract: The present invention relates to a blood testing bottomed tube, which comprises a tubular member having an open one end and closed another end, and a coating layer formed on at least a part to be contacted with blood on said tubular member, said coating layer being made of a polyoxyalkylene alkyl ether or a polyoxyalkylene glycol ether, the present invention also relates to a stopper for a blood testing bottom tube and a blood testing container.Type: GrantFiled: July 7, 2008Date of Patent: April 1, 2014Assignee: Sekisui Chemical Co., Ltd.Inventors: Masaaki Minamoto, Hironobu Isogawa
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Publication number: 20140087406Abstract: An article for detecting Salmonella microorganisms is provided. The article comprises a highly selective nutrient medium and a plurality of indicator systems. A method of using the article to detect Salmonella microorganisms is also provided.Type: ApplicationFiled: May 14, 2012Publication date: March 27, 2014Inventors: Patrick A. Mach, Mara S. Reif-Wenner
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Patent number: 8679855Abstract: In the present invention, it is demonstrated for the first time, the influence of electrical current on the ability of surface plasmons to amplify fluorescence signatures. An applied direct current across silver island films (SiFs) of low electrical resistance perturbs the fluorescence enhancement of close-proximity fluorophores. For a given applied current, surface plasmons in “just-continuous” low resistance films are sparsely available for fluorophore dipole coupling and hence the enhanced fluorescence is gated as a function of the applied current.Type: GrantFiled: March 1, 2009Date of Patent: March 25, 2014Assignee: University of Maryland, Baltimore CountyInventor: Chris D. Geddes
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Patent number: 8673582Abstract: The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers. The disclosure also relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual is carrying a fetus having a chromosomal abnormality based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers.Type: GrantFiled: July 18, 2013Date of Patent: March 18, 2014Assignees: Wallac Oy, The Fetal Medicine FoundationInventors: Howard Cuckle, Kypros Nicolaides
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Patent number: 8669098Abstract: For the purpose of improving the accuracy of a variety analyses using a bio-microarray, it is a main object of the invention to provide a bio-microarray capable of producing relatively high signal intensity from a fluorescent molecule and capable of having improved quantification performance and to provide a substrate for bio-microarray. In order to achieve the object, the invention provides a substrate for bio-microarray characterized by having a reflection-suppressing function.Type: GrantFiled: October 6, 2010Date of Patent: March 11, 2014Assignee: Dai Nippon Printing Co., Ltd.Inventor: Hideshi Hattori
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Patent number: 8658384Abstract: The present invention relates to combinations of biomarkers and levels thereof that may be used, for example, in the determination of risk associated with the occurrence of a major adverse cardiac event (MACE) in a patient.Type: GrantFiled: June 25, 2013Date of Patent: February 25, 2014Assignee: Abbott LaboratoriesInventors: Saul A. Datwyler, Jessie W. Shih, Robert C. Doss, Walter J. Keirans, Sudarshan Hebbar
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Patent number: 8658422Abstract: The present invention pertains to a culture plate, and in particular to a culture plate comprising a lid wherein the peripheral side wall of the lid is formed at least partially of at least one filter element made of a filter material. This enables lateral, uniform ventilation of the culture plate even in a stacked arrangement of the culture plate, avoiding at the same time significant loss of culture medium by evaporation.Type: GrantFiled: February 2, 2009Date of Patent: February 25, 2014Assignee: Eppendorf AGInventor: Jochen Beese
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Patent number: 8652789Abstract: A method is provided for the diagnosis or prognosis of a disease state, involving the measurement of a parameter of discriminated dipeptidyl dipeptidases from a patient sample, and the correlation of the parameter with a disease.Type: GrantFiled: March 13, 2007Date of Patent: February 18, 2014Assignee: Becton, Dickinson and CompanyInventors: Patrick O'Mullan, Craig A. Gelfand
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Patent number: 8642321Abstract: The assembly comprises a filtration unit and a gel growth medium cassette, the unit and the cassette being adapted to cooperate in order to occupy a nested position in which a membrane covers the gel growth medium, the unit and the cassette each being equipped with an intermediate stop, it being possible for at least one of the two stops to move clear so as to allow the unit to move from an intermediate position, in which the membrane is spaced away from the gel growth medium, into the nested position. The method comprises selecting such an assembly, of engaging the unit on the cassette until the intermediate stop of the unit comes into contact with the intermediate stop of the cassette, and the step of moving clear the stop able to move clear so as to allow the unit to move from the intermediate position into the nested position.Type: GrantFiled: April 14, 2008Date of Patent: February 4, 2014Assignee: EMD Millipore CorporationInventors: Stephane Olivier, Mathieu Arrault
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Publication number: 20140024016Abstract: The present invention relates to novel lateral flow devices using two dimensional features, preferably, uniform two dimensional test and control features, to provide flow control information, to function as an internal control and/or to provide internal calibration information for the test device. The present invention also relates to methods for using the lateral flow devices to provide flow control information, to function as an internal control and/or to provide internal calibration information for the test device.Type: ApplicationFiled: March 13, 2013Publication date: January 23, 2014Inventors: Brendan O'FARRELL, Thomas C. TISONE
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Publication number: 20140024106Abstract: A diagnostic test apparatus for determining a ratio of: (a) at least one endogenous protease enzyme inhibitor, to (b) at least one endogenous protease enzyme, in a sample of a wound fluid. Suitably the protease enzyme is a neutrophil elastase and the protease enzyme inhibitor is alpha-1-antitrypsin. Also provided are wound treatment systems comprising an apparatus according to the invention and a wound dressing comprising an oxidized cellulose. Also provided are methods of diagnosis, prognosis and treatment of wounds using the apparatus and systems of the invention.Type: ApplicationFiled: July 26, 2013Publication date: January 23, 2014Inventor: Breda Mary Cullen
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Publication number: 20140024045Abstract: The present invention relates to devices and methods for the measurement of cell traction forces. In particular, the invention is based on the use of a soft substrate with cell adhesive micropatterns.Type: ApplicationFiled: February 6, 2012Publication date: January 23, 2014Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Manuel Thery, Qingzong Tseng
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Patent number: 8632969Abstract: A method and a device for detecting nucleic acid are disclosed, wherein impurities in a sample can be easily removed. The method comprises injecting a sample containing an adsorption medium with nucleic adsorbed thereon into a chamber; washing the sample; heating the sample to denature the nucleic acid; cooling down; and detecting nucleic acid by using the biomolecule detection device. The device includes: a source and a drain region; a gate electrode layer; a chamber formed over the semiconductor substrate including the gate electrode layer; and a heating means, wherein a gate adsorption layer to which a nucleic acid is adsorbed is formed on the gate electrode layer. A single-stranded nucleic acid is adsorbed to the gate adsorption layer, and a channel is formed between the source and the drain region. The current in the channel provides a basis to detect a gene.Type: GrantFiled: June 18, 2008Date of Patent: January 21, 2014Assignee: Samsung Electronics Co., Ltd.Inventors: Jeo Young Shim, Jung Im Han, Won Seok Chung
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Patent number: 8632730Abstract: In one aspect, a diagnostic test system includes a receptacle, optical detectors, and a logic circuit. Each of the optical detectors has a corresponding view in the receptacle and produces an electrical signal at a respective detector output in response to light from the corresponding view. The logic circuit includes logic inputs that are respectively coupled to the detector outputs and that produce an output logic signal corresponding to a logical combination of signals received at the logic inputs. In another aspect, respective detection signals are produced in response to light received from respective ones of multiple views of the test strip, and at least one output logic signal corresponding to a respective logical combination of the detection signals is generated.Type: GrantFiled: November 22, 2005Date of Patent: January 21, 2014Assignee: Alverix, Inc.Inventors: John F. Petrilla, Daniel B. Roitman
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Patent number: 8632966Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.Type: GrantFiled: January 10, 2013Date of Patent: January 21, 2014Assignee: Queen's University at KingstonInventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J. P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Raymond J. Bowers, Robin A. Wynne-Edwards, John G. St. Marseille
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Patent number: 8628953Abstract: In order to make a process of capturing and testing air-borne microorganisms more convenient and quick, a capturing device which comprises the capturing carrier comprising a polymer which is in a gel phase at the time of capturing the microorganisms but undergoes a phase transition under heating to a sol phase at the temperature at or less than 40° C. (especially in the temperature range between 15° C. and 37° C.), and a vessel to contain the capturing carrier is used. Further, by comprising a test reagent in the polymer, the test reagent can be eluted upon said phase transition from a gel phase to a sol phase. By heating the capturing carrier, a phase transition to a sol phase can occur at or less than 40° C. As such, since recovery of microorganisms and addition of a test reagent to the microorganisms can be carried out simultaneously, the process can be simplified and the process time can be shortened.Type: GrantFiled: November 21, 2008Date of Patent: January 14, 2014Assignee: Hitachi Plant Technologies, Ltd.Inventors: Noe Osato, Ryusuke Gotoda, Satoshi Ozawa, Hideyuki Noda, Masahiro Okanojo
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Patent number: 8614101Abstract: Devices and methods incorporate lysis agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters a lysis agent. The lysis agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the initially lysis agent is localized between the sample application zone and the conjugate zone. The lysis agent is preferably soluble or miscible in the sample transport liquid, and the lysis agent is solubilized and activated upon contact with the sample transport liquid. The sample transport liquid then contains both lysis agent in solution or suspension and sample components in suspension. Any lysis-susceptible components in a sample, then being exposed in suspension to the lysis agent, are themselves lysed in situ. The running buffer then carries the analyte, including any lysis-freed components, to the detection zone.Type: GrantFiled: July 14, 2009Date of Patent: December 24, 2013Assignee: Rapid Pathogen Screening, Inc.Inventors: Robert W. VanDine, Uma Mahesh Babu, Robert P. Sambursky
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Patent number: 8609043Abstract: The present invention relates to the use of a container, made of an inorganic additive containing plastic material, for reducing physical/chemical interaction between the container and an oil, fat and/or wax containing formulation contained therein.Type: GrantFiled: August 6, 2012Date of Patent: December 17, 2013Assignee: M & P Patent AktiengesellschaftInventor: Claudia Mattern
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Patent number: 8609044Abstract: A micro vial assembly for performing microwave-assisted chemical reactions on small reaction mixture volumes is disclosed, wherein a reaction vessel (10) is sealed through a diaphragm (30) that is capped over an open end of the reaction vessel. The reaction vessel mouths in an end plane of a sleeve (20) surrounding the reaction vessel, the diaphragm being clamped for sealing the open end of the vessel by means of a cap (40) which is secured to the sleeve. The sleeve provides a radial extension of the reaction vessel in order to bridge the radial distance between a wall of the reaction vessel and other components in a system for performing microwave-assisted chemical reactions.Type: GrantFiled: December 18, 2003Date of Patent: December 17, 2013Assignee: Biotage ABInventors: Johan Ulin, Per-Gunnar Eriksson, Fredrik Ekdahl
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Publication number: 20130330815Abstract: The present invention relates to compositions, devices and methods for detecting microorganisms (e.g., anthrax). In particular, the present invention provides portable, surface-enhanced Raman biosensors, and associated substrates, and methods of using the same, for use in rapidly detecting and identifying microorganisms (e.g., anthrax).Type: ApplicationFiled: August 28, 2007Publication date: December 12, 2013Applicant: Northwestern UniversityInventors: Richard P. Van Duyne, Xiaoyu Zhang, Jing Zhao, Alyson V. Whitney, Jeffrey W. Elam, George C. Schatz, Peter C. Stair, Shengli Zou, Matthew Young, Olga Lyandres
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Patent number: 8603835Abstract: Test cells have a first sorbent strip with a sample receiving location and defining a first migration path, a distinct second sorbent strip which receives buffer solution and at least partially defines a second migration path distinct from and elongated relative to the first migration path, conjugate supported by the second strip, a test site located at a junction of the first and second strips and having an immobilized ligand-binding mechanism, and a divider which directs a first amount of the buffer to the first strip to move the sample to the test site and a second amount to the second strip to move the conjugate to the test site. The first and second migration paths have first and second lengths chosen so that ligand in the sample reaches the test site and binds to the immobilized ligand-binding mechanism prior to the conjugate reaching the test site.Type: GrantFiled: February 10, 2011Date of Patent: December 10, 2013Assignee: Chembio Diagnostic Systems, Inc.Inventor: Javanbakhsh Esfandiari
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Publication number: 20130323828Abstract: A urine test sheet which can reduce the workload of a person performing a test through the use of a urine test sheet, caused by the above-mentioned temporary restriction and which makes it possible to obtain a determination result having high reliability. The urine test sheet includes a support, and a reaction reagent which is formed on the support, and by the urine test sheet being immersed in urine to be a specimen and then being taken out, shows a reaction for a prescribed subject to be tested after a prescribed period of time, wherein a detection member in a pad-like shape including the reaction reagent and a reaction-terminating agent having an action causing the reaction to terminate is formed on the support, the reaction-terminating agent is covered with a water-soluble material, and the water-soluble material causes the reaction-terminating agent to act by being dissolved by moisture in the urine.Type: ApplicationFiled: February 15, 2012Publication date: December 5, 2013Inventor: Takahito Matumura
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Patent number: 8597903Abstract: The present technology discloses biotinidase assay, biotinidase substrates (I) and a kit wherein the biotinidase substrate includes a label molecule separated from the biotin carbamoyl group by a linker X longer than about 4 ? but shorter than about 27 ?.Type: GrantFiled: March 10, 2010Date of Patent: December 3, 2013Assignee: Wallac OyInventors: Jarkko Karvinen, Pertti Hurskainen, Pekka Mattsson, Outi Mulari, Jari Peuralahti, Lassi Jaakkola
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Publication number: 20130295601Abstract: A system is provided that simulates the in vivo micro-environment of three-dimensional cellular structures or bodies, such as tumors. The system simulates the pressure gradients and fluid flows of the vascular and lymphatic systems as well as the interstitial and capillary transport mechanisms between the 3D cellular structure and the vascular and lymphatic systems. The system can be used to introduce drugs or drug delivery carriers to a tumor, for example, to assess the uptake capability and effect on the tumor. The system maintains the viability of the tumor cells for a sufficiently long period of time to permit testing of several different drugs and/or delivery carriers.Type: ApplicationFiled: May 3, 2013Publication date: November 7, 2013Applicant: Purdue Research FoundationInventors: Kinam Park, Bumsoo Han, Bongseop Kwak, Crystal Soo Jung Shin
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Patent number: 8574858Abstract: The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies reactive with the analyte.Type: GrantFiled: October 2, 2012Date of Patent: November 5, 2013Assignee: Abbott LaboratoriesInventors: Maciej Adamczyk, Roy Jeffrey Brashear, Phillip G. Mattingly
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Publication number: 20130288353Abstract: A kinase is used in a biological indicator for validation of treatment processes designed to reduce the amount or activity of a biological agent in a sample. The indication can be used for validation of sterilisation treatment. The formation of ATP from a substrate comprising ADP is measured via the liciferin/luciferate system in a luminameter. Thermostable adenylate kinase from sulfolobus acidocaldarius is especially suitable for the validation of procedures to inactivate transmissable spongiform encephalopathy agents.Type: ApplicationFiled: February 25, 2013Publication date: October 31, 2013Applicant: Health Protection AgencyInventors: J. Mark Sutton, Neil David Hammond Raven
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Patent number: 8568993Abstract: A diagnostic method for determining the absence or presence of a disease is provided. The method includes assaying the amount and/or types of glycopeptides in a sample from a subject, and comparing these to the amount and types of reference glycopeptides. The method may include the use of a stable isotope label, affinity selection, immunoaffinity chromatography, and glycoproteomics techniques, to identify and quantify changes in glycosylated peptides or glycosylated proteins associated with cancers such as malignant lymphoma or breast cancer, to monitor patient's response to therapy, and to monitor disease recurrence.Type: GrantFiled: June 30, 2008Date of Patent: October 29, 2013Assignee: Purdue Research FoundationInventors: Fred E. Regnier, Stephen B. Hooser, Christina R. Wilson, Wonryeon Cho
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Patent number: 8568997Abstract: A system for the detection of molecular associations, the system comprising: i) a first agent, comprising a first interacting group coupled to a first reporter component; ii) a second agent, comprising a second interacting group coupled to a second reporter component; iii) a third agent, comprising a third interacting group; iv) a modulator; and v) a detector; wherein proximity of the first and second reporter components generates a signal capable of detection by the detector; and wherein the modulator modulates the association of the second interacting group with the third interacting group; such that monitoring the signal generated by proximity of the first and second reporter components by the detector constitutes monitoring the association of the first and third agents.Type: GrantFiled: September 10, 2012Date of Patent: October 29, 2013Assignee: Dimerix Bioscience Pty Ltd.Inventors: Kevin Donald George Pfleger, Ruth Marie Seeber, Heng Boon See, Karin Ann Eidne
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Patent number: 8563330Abstract: The invention provides a device and method for the rapid identification of patients suspected of having thalassemia. The invention provides a test strip for the aqueous detection of thalassemia related proteins in whole blood. The test strip includes antibodies specific to the gamma 4, (?4) protein and provides easy visual discrimination between a positive result and a negative result. The invention can be used in remote or clinical settings.Type: GrantFiled: March 21, 2008Date of Patent: October 22, 2013Assignee: National Science and Technology Development AgencyInventors: Watchara Kasinrerk, Chatchai Tayapiwatana, Thanusak Tatu, Suthat Fucharoen, Sawitree Chiampanichayakul
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Patent number: 8557195Abstract: A sensor substrate includes a base and fibrous projections on an upper surface of the base. The fibrous projections have fixed ends fixed to the upper surface of the base and free ends opposite to the fixed ends, respectively. The fibrous projections provide a fixed end-side region including the fixed ends and a free end-side region including the free ends. The total surface area at which the fibrous projections in the fixed end-side region is larger than that in the free end-side region.Type: GrantFiled: September 14, 2012Date of Patent: October 15, 2013Assignee: Panasonic CorporationInventors: Masaya Nakatani, Makoto Takahashi, Takuya Oka
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Patent number: 8557604Abstract: A lateral flow, membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes phosphorescence to detect the signals generated by excited phosphorescent labels. The labels may have a long emission lifetime so that background interference from many sources, such as scattered light and autofluorescence, is practically eliminated during detection. In addition, the phosphorescent labels may be encapsulated within particles to shield the labels from quenchers, such as oxygen or water, which might disrupt the phosphorescent signal.Type: GrantFiled: December 14, 2007Date of Patent: October 15, 2013Assignee: Kimberly-Clark Worldwide, Inc.Inventor: Xuedong Song
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Patent number: 8546598Abstract: The invention relates to a silane compound including a cycloalkyne functionality, to a method for functionalising a solid substrate, and to the solid substrate thus produced. The silane compound of the invention corresponds to the formula X-E-A-Z where X is a silyl group, E is an organic spacer group, A is a single bond or a —CONH—, —NHCO—, —OCH2CONH—, —NHCOCH2O—, —O— or —S— group, and Z is a cycloalkyne or heterocycloalkyne with at least 8 members. The invention is particularly suitable for use in the field of medicine.Type: GrantFiled: March 16, 2010Date of Patent: October 1, 2013Assignee: Commissariat a l'Energie Atomique et aux Energies AlternativesInventors: Aude Bernardin, Guillaume Delapierre, Antoine Hoang, Isabelle Texier-Nogues
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Patent number: 8545760Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.Type: GrantFiled: September 28, 2007Date of Patent: October 1, 2013Assignee: Sysmex CorporationInventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
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Patent number: 8541227Abstract: The inventions relates to compositions and method for determining the absolute counts of cells per unit volume of a sample. Such a method comprises: (a) providing a container containing (i) a predetermined quantity of microparticles; and (ii) a cell-binding agent; in which the microparticles are disposed in or on a matrix which adheres to at least one wall of the container such that substantially all the microparticles are thereby attached to the container; (b) adding a known volume of sample to the container; (c) determining the ratio of microparticles to cells by counting microparticles and cells in a volume of the sample; and (d) determining the absolute count of cells by multiplying the number of cells per microparticle by the concentration of microparticles in the sample.Type: GrantFiled: February 6, 2006Date of Patent: September 24, 2013Assignee: Dako Denmark A/SInventors: Nanna K Christensen, Jesper Laursen, Lars Winther
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Publication number: 20130244249Abstract: Hierarchical films with structurally regulated functionalities through the integration of two-dimensional and three-dimensional structures to achieve ultra low nonspecific binding and high loading of molecular recognition elements, and methods for making and using the films.Type: ApplicationFiled: January 22, 2013Publication date: September 19, 2013Inventors: Shaoyi Jiang, Norman David Brault, JR., Harihara S. Sundaram, Chun-Jen Huang, Qiuming Yu, Yuting Li
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Patent number: 8530230Abstract: The present invention is directed to methods for conducting multiplexed assays. The methods are particularly well suited for measuring a plurality of analytes that may be present in very different abundances. The invention also relates to systems, devices, equipment, kits and reagents for use in such methods.Type: GrantFiled: July 16, 2012Date of Patent: September 10, 2013Assignee: Meso Scale Technologies, LLCInventors: Selen A. Stromgren, Eli N. Glezer
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Patent number: 8524462Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects in the context of renal artery stenosis (RAS). In particular, the invention relates to using assays that detect NGAL, their use to diagnose RAS in subjects suffering from hypertension, and their use in prognosis, particularly of mortality and worsening renal function.Type: GrantFiled: November 14, 2007Date of Patent: September 3, 2013Assignee: Alere San Diego, Inc.Inventors: Gunars Valkirs, Paul H. McPherson
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Patent number: 8524488Abstract: The present invention provides methods of determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, and biological state. The method generally involves detecting membrane movement in a cell to determine a characteristic of a cell. The methods of the invention are useful for applications such as drug screening and diagnostics. The invention further provides databases of cell characteristics, as determined by the instant methods. The invention further provides systems for determining the characteristic of a cell.Type: GrantFiled: March 9, 2005Date of Patent: September 3, 2013Assignee: The Regents of the University of CaliforniaInventors: James K. Gimzewski, Andrew E. Pelling
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Patent number: 8524463Abstract: The invention relates to a method for diagnosis and/or risk classification for acute coronary syndrome (ACS), in particular for acute myocardial infarct (AMI) and angina pectoris (AP) and/or a post-myocardial infarct, wherein a determination of the C-terminal pro-endothelin (CT-proET-1) or fragments and partial peptides therefrom, is carried out in combination with NT-proBNP.Type: GrantFiled: December 22, 2007Date of Patent: September 3, 2013Assignee: B.R.A.H.M.S GmbHInventors: Andreas Bergmann, Nils Morgenthaler, Jana Papassotiriou, Joachim Struck, Leong L. Ng
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Patent number: 8518342Abstract: The present invention relates generally to the field of analysis, for example biological analysis.Type: GrantFiled: June 24, 2005Date of Patent: August 27, 2013Assignee: BiomerieuxInventors: David Mosticone, Pascal Montes, Jean-Claude Raymond, Bruno Colin, Cecile Paris
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Publication number: 20130217598Abstract: The invention provides a platform technology with rich ability to flexibly perform, create, deploy, maintain, and update a wide range of panels, assay, array, and/or sequence of tests for a wide range of substances and pathogens. The invention provides a unifying framework for widely-ranging miniature sensor implementation, fluidic/gas interfacing, electrical interfaces and optical interfaces, and further by collocating, allowing the integration a large number highly-selective sensors and chemical sensors—together as needed with appropriately selected supplemental sensors (for example temperature, pH, selective ions, etc.), into a common readily-manufacturable framework. The diverse sensor arrays give rise to statistical enhancing through novel statistical processing approaches.Type: ApplicationFiled: February 6, 2013Publication date: August 22, 2013Inventors: Lester F. Ludwig, Pooncharas Tipgunlakant
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Patent number: 8507260Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/ matrix interface, allowing accurate sequential draining of liquid from the reservoirs.Type: GrantFiled: June 2, 2010Date of Patent: August 13, 2013Assignee: Realbio Technologies, Ltd.Inventors: Sara Alajem, Avraham Reinhartz
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Patent number: 8506903Abstract: According to one embodiment of the present invention, an optical-based test sensor for use in the determination of an analyte in a liquid sample is disclosed. The test sensor includes a base, a polymer carrier, and a test membrane. The base has a capillary channel formed in a surface of the base that is adapted to move a liquid sample from an inlet to a reaction area formed in the base. The polymer carrier has a lower surface adhered to the surface of the base and is disposed over at least a portion of the capillary channel. The test membrane, which contains a reagent, is adhered to the lower surface of the polymer carrier and extends from the polymer carrier into the reaction area.Type: GrantFiled: March 9, 2012Date of Patent: August 13, 2013Assignee: Bayer HealthCare LLCInventor: Rex J. Kuriger
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Patent number: 8501423Abstract: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.Type: GrantFiled: July 6, 2012Date of Patent: August 6, 2013Assignee: Board of Regents, The University of Texas SystemInventors: Maher Albitar, Michael J. Keating, Taghi Manshouri