Including Measuring Or Testing Patents (Class 435/287.1)
  • Patent number: 11028452
    Abstract: The present invention relates to a primer pair comprising a forward primer and a reverse primer for amplifying a nucleic acid from a pathogen associated with a skin, hair and nail infection comprising SEQ ID NO:22, a nucleic acid capable of hybridizing specifically to a nucleic acid sequence from a pathogen associated with a skin, hair and nail infection comprising SEQ ID NO:22, a carrier comprising the nucleic acid, a method comprising the step detecting in a sample a nucleic acid sequence comprising SEQ ID NO:22 from a pathogen associated with a skin, hair and nail infection, a use of the primer pair, the nucleic acid or the carrier for the diagnosis of a disease and a kit comprising the primer pair, the nucleic acid and/or the carrier for the diagnosis of a disease.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: June 8, 2021
    Assignee: EUROIMMUN Medizinische Labordiagnostika AG
    Inventors: Melanie Harder, Yvonne Graeser, Christiane Kupsch, Markus Cavalar
  • Patent number: 11022550
    Abstract: The invention relates to a method for observing a sample (12), the sample (12) comprising a set of organisms (14), a solid substrate (16) supporting the set of organisms (14). The method being characterized in that the method includes steps for illuminating at least one portion of the sample (12) with a light beam, for acquiring a first diffraction pattern corresponding to an image of waves from the diffraction of the light beam by at least one portion of the set of organisms (14), for acquiring a second diffraction pattern corresponding to an image of waves from the diffraction of the light beam by at least one portion of the sample (12), for comparing the second diffraction pattern with the first diffraction pattern, for determining at least one characteristic relating to the set of organisms (14) from the result of the comparison step.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: June 1, 2021
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, BIOMERIEUX
    Inventors: Pierre Marcoux, Mathieu Dupoy
  • Patent number: 11021750
    Abstract: Biomarkers useful for the diagnosis and treatment of acute ischemic stroke are disclosed. Also provided is a quantitative assay method for accurately identifying transcript number in a biological sample.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: June 1, 2021
    Assignee: THE RESEARCH FOUNDATION FOR STATE UNIVERSITY OF NEWYORK
    Inventors: Alison E. Baird, Mateusz Adamski
  • Patent number: 11002732
    Abstract: Disclosed is method of improving flow of a liquid sample in an assay device, as well as a method of performing an assay on a liquid sample for the detection of one or more analytes of interest. The methods use the addition of a reagent, such as a wash reagent, to wet the fluid flow path of a sample prior to sample addition, thereby improving flow of the sample through the fluid flow path that has been wetted as opposed to flow of the sample through the fluid flow path that has not been wetted. The reagent wets the fluid flow path between the sample addition zone and the wicking zone.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: May 11, 2021
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Zhong Ding, Philip C. Hosimer, Edward Scalice
  • Patent number: 10994271
    Abstract: The present invention provides a membrane carrier 3 for a test kit of detecting a target substance in a liquid sample, comprising at least one flow path 2 transporting the liquid sample, wherein a microstructure producing capillary action for transporting the liquid sample is formed at a bottom of the flow path 2, and the microstructure is provided to change along a transport direction d of the liquid sample.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: May 4, 2021
    Assignee: Denka Company Limited
    Inventors: Yuto Akiyama, Kenji Monden
  • Patent number: 10988723
    Abstract: The present invention relates to modular assemblies and systems for conducting cell analyses. In particular embodiments, an assembly has micron-scale fluidic structures, thereby minimizing sample use, and possesses a modular architecture that facilitates disassembly of the apparatus. Thus, one such modular assembly facilitates on-chip cell growth and on-chip assays; and then, as needed, the assembly can be disassembled to provide direct access to the cells that were incubated and treated within the chip. Methods of making and using such assemblies, as well as systems thereof, are further described herein.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: April 27, 2021
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Anson Hatch, Vinay Abhyankar, Chung-Yan Koh
  • Patent number: 10969390
    Abstract: A method for evaluating an efficacy of a chemoradiotherapy against squamous cell carcinoma comprises the following steps (a) to (c): (a) detecting an expression level of at least one gene selected from a SIM2 gene and genes co-expressed with the SIM2 gene in a squamous cell carcinoma specimen isolated from a subject; (b) comparing the expression level detected in the step (a) with a reference expression level of the corresponding gene; and (c) determining that an efficacy of a chemoradiotherapy against squamous cell carcinoma in the subject is high if the expression level in the subject is higher than the reference expression level as a result of the comparison in the step (b).
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: April 6, 2021
    Assignees: NATIONAL CANCER CENTER, KYOTO UNIVERSITY, OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Hiroki Sasaki, Kazuhiko Aoyagi, Manabu Muto, Hiroo Takahashi
  • Patent number: 10961492
    Abstract: A microfluidic device for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs that includes a culture chamber may include: a confinement apparatus configured to define at least one compartment configured to contain a cellular matrix and at least one compartment configured to contain a culture medium, the confinement apparatus being hydrophobic and pervious to the culture medium; and/or at least one counter element. The confinement apparatus and at least one counter element may be reciprocally mobile between resting and compression positions of the cellular matrix. A method for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs at a microscale may include: controlled compression of a cellular matrix for a predetermined period of time. The cellular matrix may be delimited by a confinement apparatus that is pervious to a culture medium.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 30, 2021
    Assignees: POLITECNICO DI MILANO, FONDAZIONE CARIPLO
    Inventors: Alberto Redaelli, Marco Rasponi, Paola Occhetta
  • Patent number: 10955351
    Abstract: An adaptation device is provided for adapting an UV-Vis cuvette to perform in-situ spectroanalytical characterization of redox processes using gas species or solutes in a controlled atmosphere, the device configured to fit the open end of a UV-Vis cuvette intended to contain products to be measured during achievement of spectroanalytical measurements. The device comprises a main body configured to form a lid covering the opened end of the cuvette, the main body having a first part and a second part; a working, a counter and a reference electrode with removable parts at the respective ends of three conductors coming from outside and passing through the main body; a gas inlet to allow introduction of a gas the gas inlet having one aperture directed to the working electrode and second aperture directed to the bottom of the cuvette, a gas outlet intended to let the reactive gas in excess to flow out of the cuvette and an solution inlet tube for titration measurements.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: March 23, 2021
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Lukas Lutz, Daniel Alves Dalla Corte, Alexis Grimaud, Jean-Marie Tarascon
  • Patent number: 10921237
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: February 16, 2021
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10914751
    Abstract: A sample is measured using a cartridge from a batch comprising a plurality of cartridges of the same type. The measurement results measured in the process are evaluated. In order to evaluate the measurement results, reference results are used in addition, which reference results were measured previously, separately, during measurements of reference samples, using a plurality of cartridges of the same batch. An analyte of the sample is determined from the measurement results. During the evaluation, the reference results and/or measurement results are preferably normalized.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: February 9, 2021
    Assignee: BOEHRINGER INGELHEIM VETMEDICA GMBH
    Inventor: Matthias Griessner
  • Patent number: 10908090
    Abstract: The invention describes generating and use of a multi-layer plasmonic slide, wherein the plasmonic slide comprises at least 6 layers of metallic nanoparticles that can enhance the detection of fluorescent signals and wherein the plasmonic slide can be printed as a microarray of any size. The microarray containing the plasmonic slide can further be printed with a protein, a glycan, or an antibody. The multi-layer plasmonic slide is capable of detecting proteins, polynucleotides, and/or glycans at orders of magnitude lower concentration than non-plasmonic substrates.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: February 2, 2021
    Inventor: Chris Geddes
  • Patent number: 10877041
    Abstract: The present disclosure provides methods for detecting biological print(s) or biological fluid(s) or target low molecular weight analyte(s) therein comprising contacting the suspected print(s) or fluid(s) with porous semiconductor substrates or microparticles (MPs) under conditions to allow said semiconductor substrates or microparticles to adhere to the print(s) or fluid(s) or analyte(s) therein, and analysing the adhered porous semiconductor substrates or MPs to detect the print(s), fluid(s) or analytes when present. The disclosure also includes method for making porous semiconductor substrates.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: December 29, 2020
    Inventor: Nicolas H. Voelcker
  • Patent number: 10859570
    Abstract: The present invention relates to an analyte detection device comprising: a sample chamber for storing a mixture solution of a sample comprising an analyte and a reactant comprising particles; a detection chamber for storing a detection solution; and a channel placed between the sample chamber and the detection chamber to prevent the mixture solution and the detection solution from being mixed with each other, the analyte detection device characterized by detecting the analyte by moving the particles from the sample chamber to the detection chamber using moving means.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: December 8, 2020
    Inventor: Suk-Jung Choi
  • Patent number: 10837960
    Abstract: An assay device including a loading zone for a sample that may contain an analyte, an activator in communication with the loading zone from which at least one activator is displaced by presence of the analyte, an amplifier in an inactive state in communication with the activator that becomes activated in the presence of the activator, a biomatrix barrier in communication with the activated amplifier that is degraded or modified by the activated amplifier, and an indicator responsive to the degradation or modification of the biomatrix barrier, which in turn reflects a concentration of the analyte in the sample loaded on the device. The selection of analyte or displacement of the activator by presence of the analyte may occur off-platform and/or may rely on use of non-covalent interactions. The activator may include an enzyme or other reagent that activates the amplifier. Also, associated methods.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: November 17, 2020
    Assignee: CALIFORNIA POLYTECHNIC STATE UNIVERSITY
    Inventors: Nathaniel Martinez, Andres Martinez
  • Patent number: 10808282
    Abstract: Substrates comprising dual functional polymer layered surfaces and the preparation thereof by using UV nano-imprinting processes are disclosed. The substrates can be used as flow cells, nanofluidic or microfluidic devices for biological molecules analysis.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: October 20, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Andrew A. Brown, Wayne N. George, Alexandre Richez, M. Shane Bowen
  • Patent number: 10794817
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: October 6, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10782226
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: September 22, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10758573
    Abstract: The present invention is directed to a device for enriching cells with a cell surface marker, comprising an aptamer suitable for specifically binding the cell surface marker, and beads coupled thereto, wherein the aptamer is coupled to the beads in a manner that allows for release of cells expressing the cell surface marker, in the absence of a chemical agent, and production of a cell population enriched for cells expressing the cell surface marker, substantially free of beads and aptamer. Kits comprising the device or components thereof, and methods of cell enrichment, are also provided. In exemplary embodiments, the device contains an aptamer that specifically binds CD31.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: September 1, 2020
    Assignees: President and Fellows of Harvard College, CHARITÉUNIVERSITÄTSMEDIZIN BERLIN
    Inventors: Pascal Joly, Georg N. Duda, Thomas Schaus, Anke Dienelt, Andrea Sass, David J. Mooney
  • Patent number: 10746648
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: August 18, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10736536
    Abstract: One embodiment of the present application sets forth a method for predicting recurrence of cancerous cells in a patient that includes measuring, by a first subset of electrodes included in an electrode array operating at a first frequency, a first impedance of a first section of a first sample of tissue excised from the patient, computing a first Cole relaxation frequency for the first section of the first sample based on the first impedance, and generating a first prediction relating to cancerous cells in the patient based at least in part on the first Cole relaxation frequency.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: August 11, 2020
    Assignee: NOVASCAN, INC.
    Inventor: William David Gregory
  • Patent number: 10725019
    Abstract: Example implementations relate to coagulation sensing. For example, a microfluidic chip for coagulation sensing may include a microfluidic channel, an outlet at an end of the microfluidic channel having an air interface, and an impedance sensor located within the microfluidic channel and within a particular proximity to the air interface, the impedance sensor to determine a stage of a coagulation cascade of a blood sample flowing through the microfluidic channel to the impedance sensor.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: July 28, 2020
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Melinda M Valencia, Chantelle E Domingue, Jeremy Sells, Manish Giri, Sadiq Bengali
  • Patent number: 10723992
    Abstract: The present disclosure provides a culture device for enumerating colonies of microorganisms. The device can comprise a base, a coversheet, and a nonporous spacer member disposed therebetween. The spacer member comprises an aperture that defines a growth compartment. At least one adhesive layer is adhered to the base or the coversheet in the growth compartment. A cold water-soluble gelling agent and an effective amount of a dry carbon dioxide-generating reagent are adhered to the at least one adhesive layer. The carbon dioxide-generating reagent consists essentially of particles having a diameter of less than 106 microns.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: July 28, 2020
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Jason W. Bjork, Evan D. Brutinel, Adam J. Stanenas
  • Patent number: 10718872
    Abstract: A photonic dosimeter accrues cumulative dose and includes: a substrate; a waveguide disposed on the substrate and that: receives a primary input light; transmits secondary input light from the primary input light to a dosimatrix; receives a secondary output light from the dosimatrix; and produces primary output light from the secondary output light; the dosimatrix disposed on the substrate and in optical communication with the waveguide and that: receives the secondary input light from the waveguide; produces the secondary output light that is communicated to the waveguide; and includes an active element that undergoes conversion from a prime state to a dosed state in response to receipt, by the active element, of a dose of radiation; and a cover layer disposed on waveguide and the dosimatrix.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: July 21, 2020
    Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS RESPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Ronald Tosh, Zeeshan Ahmed, Ryan P. Fitzgerald, Nikolai Klimov
  • Patent number: 10675724
    Abstract: A mobile system and method for separating lubricants from swarf material streams provides on-site recovery of lubricants in an efficient, effective, sustainable and economic manner. The system thus reduces the need to transport relatively large volumes of swarf and lubricant material stream to a remote location for disposal. The system includes swarf of various types, for example, aluminum, steel, precious metals, plastic, etc. mixed with various water based or oil based lubricants. A trailer or motor vehicle containing a power supply, a basket centrifuge(s) connected to the power supply for powered operation thereof, a live bottom conveyor for supplying swarf to the centrifuges, a portable feed hopper with attached augers for supplying swarf to the live bottom conveyor, a bag liner to filter the extracted lubricant as it exits the basket, a crane for lifting the bag liner out of the basket, a container to accumulate the dried swarf, a container to accumulate the extracted lubricant.
    Type: Grant
    Filed: May 6, 2018
    Date of Patent: June 9, 2020
    Inventor: Justin Edmondson
  • Patent number: 10669579
    Abstract: A sensing device includes a stack of dielectric layers having conductive materials disposed between the dielectric layers. A nanopore is disposed through the stacks of dielectric layers and separates the conductive materials to provide electrodes on opposite sides of the nanopore. Contacts connect to each of the electrodes.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: June 2, 2020
    Assignee: International Business Machines Corporation
    Inventors: Zhenxing Bi, Kangguo Cheng, Juntao Li, Xin Miao
  • Patent number: 10670490
    Abstract: The present invention relates to a method for a measurement system configured to test a flexible bio-process bag, the method comprising providing at least one flexible bio-process bag having a volume, wherein the at least one flexible bio-process bag is initially filled with a gas and inflated to a reference pressure (Pu), obtaining a leak model, obtaining baseline information, wherein the baseline information comprises at least a weighed first mass value (mbaseline) and a first time value (t1), obtaining evaluation information, wherein the evaluation information comprises at least a weighed second mass value (mevaluation) and a second time value (t2), testing the flexible bio-process bag based on the leak model, the baseline information and the evaluation information.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: June 2, 2020
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Robert Douglas Burchesky, James Molloy
  • Patent number: 10655166
    Abstract: Apparatus and methods are disclosed for electrically active combinatorial-chemical (EACC) chips for biochemical analyte detection. An apparatus includes a substrate that has an array of regions defining multiple cells, wherein each of the cells includes a reaction cavity that contains multiple functional binding groups. A method of detecting an analyte providing the reaction cavity between a source and a drain or a pair of electrodes, applying a voltage and monitoring a parameter indicative of an analyte characteristic. A process of fabricating an EACC include bonding an analyte to the multiple functional binding groups of each reaction cavity, and forming an analyte sensing structure including the substrate.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: May 19, 2020
    Assignee: Intel Corporation
    Inventors: Xing Su, Lei B. Sun, Jacque H. Georger, Jr.
  • Patent number: 10656116
    Abstract: A microbial sensor, system, and method that can be used to determine a chemical environment and/or substrate concentrations in anaerobic or aerobic environments, such as soils, sediments and ground waters, are disclosed. An exemplary system uses one or more (e.g., inert) measurement electrodes and a reference electrode. The reference electrode can include an electrode exposed to atmospheric oxygen (e.g., a cathode) or an electrode exposed to stable anaerobic or aerobic conditions. The exemplary microbial sensor system measures open-circuit voltage to characterize the chemical (oxidizing or reducing) environment and/or recovery voltage to measure substrate concentrations in the subsurface.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: May 19, 2020
    Inventors: Scott R. Burge, Russell G. Burge, David A. Hoffman
  • Patent number: 10641700
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: May 5, 2020
    Assignee: Celsee Diagnostics, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10591404
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: March 17, 2020
    Assignee: Celsee Diagnostics, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10572996
    Abstract: A method for annotating a tissue slide image, a system and a method performed by a computing system for detecting pathological anomalies in a digital pathology image are disclosed. The method performed by a computing system for detecting pathological anomalies in a digital pathology image includes providing a digital pathology image to the computing system and analyzing the digital pathology image using an identification module arranged on the computing system. The identification module uses a machine learning module to execute recognizing an object containing an abnormal image pattern using an identification model loaded in said identification module and identifying whether the abnormal image pattern corresponds to a pathological anomaly using the identification model.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: February 25, 2020
    Assignee: CONTEXTVISION AB
    Inventor: Kristian Eurèn
  • Patent number: 10533936
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: January 14, 2020
    Assignee: Celsee Diagnostics, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10489104
    Abstract: A method and apparatus for generating harmonics using polynomial non-linear functions. Polynomial functions are used to produce harmonics of an input signal up to a predetermined order, and that match a preferred set of characteristics. The preferred characteristics include approximating a sine function to generate odd harmonics, and using a function with zero slope at ?1, 0, and +1 to generate even harmonics. The polynomial coefficients may be chosen such that most of the coefficients for the odd polynomial function are scaled by the same constant as the coefficients for the even polynomial function, so that the calculation is shared between the two polynomials. In one embodiment, a digital signal processor having a pipelined ALU and a MAC is used to calculate the desired polynomial non-linear functions.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: November 26, 2019
    Assignee: TEMPO SEMICONDUCTOR, LLC
    Inventor: Darrell Eugene Tinker
  • Patent number: 10480034
    Abstract: The application discloses new biomarkers and methods useful in the diagnosis, prognosis and/or monitoring of, or as a therapeutic or research target for, solid tumour cancers, such as colorectal cancer, based on measuring the biomarkers; and related kits and devices.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: November 19, 2019
    Inventor: Jeffrey Lordan
  • Patent number: 10465158
    Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: November 5, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Donald E. Ingber, Daniel Levner, Guy Thompson, II, Jose Fernandez-Alcon, Christopher David Hinojosa
  • Patent number: 10468135
    Abstract: A system for automatically detecting and displaying sepsis images in a hospital system is described herein. In some examples, the system can include receiving data related to a plurality of physiological parameters from a patient over time, and identifying and organizing patterns of perturbations of the data. The system can also include analyzing the perturbations to identify known relational physiologic patterns and detecting a pattern of sepsis, the pattern being comprised of a plurality of perturbations and/or relational physiologic patterns. Furthermore, the system can include organizing and synthesizing the plurality of relational physiologic patterns into a set of sepsis images, which as an aggregate whole make up an image representation of the complex and dynamic state of sepsis, and displaying the sepsis images. The images can be color motion images of cascades which display the severities of individual perturbations and relational physiologic patterns along the cascade pattern.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: November 5, 2019
    Inventor: Lawrence A. Lynn
  • Patent number: 10441205
    Abstract: An arrangement includes a housing, a plurality of sampling and analysis sites contained within the housing, each of the sampling and analysis sites having a skin-penetration member having a first end configured to pierce the skin, and an inner lumen in communication with the first end, an actuator operatively associated with the skin-penetration member, and an analyte quantification member in fluid communication with the inner lumen of the skin-penetration member. Integrated devices including such arrangements are also described.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: October 15, 2019
    Assignee: Intuity Medical, Inc.
    Inventors: Craig M. Litherland, Jeffrey L. Emery, Raul Escutia, James W. Pfeiffer, Jeffrey M. Jones
  • Patent number: 10436700
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: October 8, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Pridyadarshini Gogoi, Christopher Siemer, Saedeh Sepehri Javdani
  • Patent number: 10416070
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: September 17, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10417938
    Abstract: The invention relates to a digestion system for analyzing the intestinal fluid. The system comprises a compartment containing the fluid content and a micro filter for filtering particles in the fluid content having a size beyond the micro range. The system further comprises a pertractor arranged downstream to the micro filter for removing digested lipophilic particles.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: September 17, 2019
    Assignee: Triskelion B.V.
    Inventor: Mans Minekus
  • Patent number: 10408737
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: September 10, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Pridyadarshini Gogoi, Christopher Siemer, Saedeh Sepehri Javdani
  • Patent number: 10408736
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: September 10, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10369573
    Abstract: Biological reagent carrier devices and methods are disclosed, which employ RFID techniques to associate information with biological reagents.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: August 6, 2019
    Assignee: Applied Biosystems, LLC
    Inventors: Richard D. Morris, Jerome A. Mack
  • Patent number: 10364411
    Abstract: A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: July 30, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Nancy Allbritton, Yuli Wang, Christopher Sims
  • Patent number: 10358641
    Abstract: Provided herein are monoliths with attached recognition compounds which selectively bind ligands, methods of preparing such monoliths, arrays thereof and uses thereof. For example, monoliths provide herein can be used in columns and arrays thereof.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: July 23, 2019
    Assignee: DiCE Molecules SV, LLC
    Inventors: Pehr Harbury, Madan Paidhungat, Robin Prince
  • Patent number: 10343163
    Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: July 9, 2019
    Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College, Vilnius University
    Inventors: Joseph Italiano, Linas Mazutis, Jonathan N. Thon, David A. Weitz
  • Patent number: 10345219
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: July 9, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Priyadarshini Gogoi, Christopher Siemer, Saedeh Sepehri Javdani
  • Patent number: 10338056
    Abstract: An apparatus for supporting an array of layers of amphiphilic molecules, the apparatus comprising: a body (11), formed in a surface of the body, an array of sensor wells (10) capable of supporting a layer of amphiphilic molecules (30) across the sensor wells, the sensor wells each containing an electrode (12) for connection to an electrical circuit, and formed in the surface of the body between the sensor wells, flow control wells capable of smoothing the flow of a fluid across the surface.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: July 2, 2019
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Jason Robert Hyde, James Anthony Clarke, Gaëlle Anne-Leonie Andreatta
  • Patent number: 10330218
    Abstract: A gating mechanism that uses a capillary stabilized liquid as a reversible, reconfigurable gate that fills and seals pores in the closed state, and creates a non-fouling, liquid-lined pore in the open state is disclosed. Theoretical modeling and experiments demonstrate that for each transport substance, the gating threshold—the pressure needed to open the pores—can be rationally tuned over a wide pressure range. This enables realizing in one system differential response profiles for a variety of liquids and gases, even letting liquids flow through the pore while preventing gas from escaping. These capabilities allow dynamic modulation of gas-liquid sorting and to separate multi-phase mixtures, with the liquid lining ensuring sustained antifouling behavior.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: June 25, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Joanna Aizenberg, Xu Hou, Mughees Khan, Alexander Tesler