Including Measuring Or Testing Patents (Class 435/287.1)
  • Patent number: 11364104
    Abstract: A first amount of sperm of a first animal and a second amount of sperm of a second animal of the same species, the first amount of sperm and the second amount of sperm sex-selected sperm of the same sex, useful in the in-vivo or in-vitro fertilization of an egg of a female animal of the same species of animal for the production of sex-selected embryos and sex-selected offspring.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: June 21, 2022
    Assignee: XY, LLC
    Inventors: Juan F. Moreno, Maurice A. Rosenstein
  • Patent number: 11364502
    Abstract: A microfluidic device includes a first substrate including at least one microfluidic channel and a plurality of microwells, as well as a cooperating second substrate defining multiple split-walled cell trap structures that are registered with and disposed within the plurality of microwells. A method for performing an assay includes flowing cells and a first aqueous medium into a plurality of microwells of a microfluidic device, wherein each microwell includes a cell trap structure configured to trap at least one cell. The method further comprises flowing a nonpolar fluid with low permeability for analytes of interest through a microfluidic channel to flush a portion of the first aqueous medium from the microfluidic channel while retaining another portion of the first aqueous medium and at least one cell within each microwell. Surface tension at a non-polar/polar medium interface prevents molecule exchange between interior and exterior portions of microwells.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: June 21, 2022
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Deirdre Meldrum, Laimonas Kelbauskas, Wacey Teller, Meryl Rodrigues, Hong Wang, Ganquan Song, Yanqing Tian, Fengyu Su, Xiangxing Kong, Liqiang Zhang
  • Patent number: 11351554
    Abstract: A carrier plate, which is used within an electrophoresis process, and to a holding device tailored to the carrier plate, the carrier plate having a region with a magnetic property and a positioning device. The magnetic property is designed to fix the carrier plate in the laboratory device. The positioning device is designed to guarantee a position of the carrier plate in the laboratory device.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: June 7, 2022
    Assignee: 4D LIFETEC AG
    Inventor: Oliver Schicht
  • Patent number: 11353452
    Abstract: The present invention provides a membrane carrier 3 comprising a flow path 2 and a detection zone 3y, wherein a microstructure is provided at the bottom of the flow path 2 and a mean surface roughness of the microstructure is 0.005 to 10.0 ?m.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: June 7, 2022
    Assignee: Denka Company Limited
    Inventors: Shuhei Aoyama, Kenji Monden
  • Patent number: 11345951
    Abstract: A system and method for capturing and analyzing a set of cells, comprising: an array including a set of parallel pores, each pore including a chamber including a chamber inlet and a chamber outlet, and configured to hold a single cell, and a pore channel fluidly connected to the chamber outlet; an inlet channel fluidly connected to each chamber inlet of the set of parallel pores; an outlet channel fluidly connected to each pore channel of the set of parallel pores; a set of electrophoresis channels fluidly coupled to the outlet channel, configured to receive a sieving matrix for electrophoretic separation; and a set of electrodes including a first electrode and a second electrode, wherein the set of electrodes is configured to provide an electric field that facilitates electrophoretic analysis of the set of cells.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: May 31, 2022
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Kalyan Handique, Priyadarshini Gogoi, Saedeh Sepehri Javdani, Yi Zhou
  • Patent number: 11340245
    Abstract: A transport device transports a container used in a sample measurement device or a rack housing the container. The transport device may include: a robotic arm configured to transport the container or the rack between a first sample measurement device and each of other sample measurement devices different from the first sample measurement device; and a controller that controls operation of the robotic arm.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: May 24, 2022
    Assignees: SYSMEX CORPORATION, KAWASAKI JUKOGYO KABUSHIKI KAISHA
    Inventors: Takaaki Nagai, Yuichiro Ohmae, Shinji Kamada, Toshiki Sato, Yukio Iwasaki, Satoshi Ouchi
  • Patent number: 11318466
    Abstract: One example includes a device that may include a heating element and a molecular binding site. The heating element may heat a fluid volume, interfaced with the heating element, in response to a voltage being applied to the heating element, the heat transforming the fluid volume from a liquid state into a vaporized state to generate fluid motion within the fluid volume. The molecular binding site may be disposed proximate to the heating element, in which a portion of the fluid volume expands when the fluid volume transforms from the liquid state into the vaporized state, the vaporized state of the fluid volume generating the fluid motion within a target fluid that is disposed within the molecular binding site.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: May 3, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: David P. Markel, Erik D Torniainen, Alexander Govyadinov, Pavel Kornilovich
  • Patent number: 11312942
    Abstract: Provided is a material-fixing substrate that does not have to use copper as a catalyst because the substrate-bonding site includes a cyclic alkyne to form a covalent bond with a surface of the substrate, and therefore that can reduce damage to a cell, for example, in a case where a to-be-fixed material is the cell. The material-fixing substrate has a to-be-fixed material fixed thereon via a material-fixing agent. The material-fixing agent includes: a substrate-bonding site that forms a covalent bond with a surface of the substrate and includes at least a cyclic alkyne; a hydrophilic site that is bonded to the substrate-bonding site; a light-responsive site that is bonded to the hydrophilic site and changes the skeleton thereof by irradiation with light; and an attachment site to which the to-be-fixed material is attached.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: April 26, 2022
    Assignee: SONY CORPORATION
    Inventors: Shunichi Suwa, Kunihiko Nagamine, Masahiro Matsumoto, Daisuke Yamaguchi, Yoshio Goto, Kyohei Yoshimitsu
  • Patent number: 11300496
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: April 12, 2022
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Kalyan Handique
  • Patent number: 11292004
    Abstract: A method for metering and storing liquids by means of a permanently open container (1), wherein: the container (1) comprises a liquid reservoir (11) in which at least one liquid (2) is contained for storage; the container (1) has at least one opening (15) for the metered discharging of the liquid from the liquid reservoir (11); the opening (15) is permanently open; influencing factors affect at least one change in pressure (4) in the container (1); influencing factors render the system formed of the container (1) and liquid (2) unstable; the pressure (4) is detected in at least one location in the container (1); and, subject to at least one detected change in pressure (4), at least one reaction (9) is initiated that is suitable for maintaining the system of the container (1) and liquid (2) in a stable state or for re-establishing this stable state.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: April 5, 2022
    Assignee: Aquila Biolabs GmbH
    Inventors: Konrad Herzog, David Frank, Carsten Presser
  • Patent number: 11248256
    Abstract: Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: February 15, 2022
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert Green, Dennis Wang, Julio Mulero, Robert Lagace
  • Patent number: 11224872
    Abstract: A pipette based on surface charges includes a pipette body. A plurality of support rods are provided below the pipette body. Connecting rods are provided at the lower ends of two adjacent support rods. A substrate is provided between the connecting rods. A porous SiO2 coating is provided on the substrate. A hydrophobic molecule layer is provided on the surface coating by the vapor deposition method. A superamphiphobic surface is formed on the substrate by the surface coating and the hydrophobic molecule layer. The substrate and the surface coating are made of dielectric materials. A circular limit plate is provided above the pipette body. The pipette body, the support rods, the connecting rods and the limit plate are integrally formed, and are electrically non-conductive. An electrically conductive sliding rod is movably provided within the pipette body and the limit plate.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: January 18, 2022
    Assignee: UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINA
    Inventors: Xu Deng, Qiangqiang Sun, Yu Zhou
  • Patent number: 11197895
    Abstract: Biologically low invasive vessels are filled with biological factors that have the activity of mobilizing specific functional cells in the body. The vessels are indwelled in the body. After specific functional cells are mobilized into the vessels, the vessels are removed from the body to collect functional cell populations mobilized to the vessels. Alternatively, the cells are directly collected from the vessels indwelled in the body.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: December 14, 2021
    Assignees: STEMRIM INC., OSAKA UNIVERSITY
    Inventors: Katsuto Tamai, Takehiko Yamazaki, Takenao Chino, Yasufumi Kaneda
  • Patent number: 11180726
    Abstract: Provided is a cell culture apparatus including a cell supply unit that supplies cells; a culture medium supply unit that supplies a culture medium; an additive supply unit that supplies an additive for inducing the differentiation of undifferentiated cells; a stirring unit that stirs a processing target; a separation unit that separates a component contained in the processing target; a culture vessel that cultures the cells; a first flow channel that forms a circulation route passing through the cell supply unit, the stirring unit, the separation unit, and the culture vessel; a second flow channel that connects the culture medium supply unit and the first flow channel; a third flow channel that connects the additive supply unit and the first flow channel; and a control unit that controls the feeding of liquid through the first flow channel, the second flow channel, and the third flow channel.
    Type: Grant
    Filed: July 4, 2019
    Date of Patent: November 23, 2021
    Assignee: FUJIFILM CORPORATION
    Inventors: Hidetoshi Takayama, Shun Goto
  • Patent number: 11149265
    Abstract: A sample preparation module accepts a sample including a target analyte. The sample preparation module processes the sample through several reaction chambers and a solid phase column. Different reagents are present in the reaction chambers. The eluted analyte is then transferred to the amplification module, where it is further processed and amplified for optical analysis.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: October 19, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Rustem Ismagilov, Erik Jue, Daan Witters
  • Patent number: 11146914
    Abstract: A method includes identifying a first user device potentially associated with a biohazard and identifying a geographic area associated with the biohazard based on previous location information of the first user device. The method further includes identifying a second user device potentially associated with the biohazard based on the geographic area associated with the biohazard and previous location information of the second user device. The method further includes issuing a safety notification to the second user device, where the safety notification includes one or more of the geographic area associated with the biohazard, a safety status request, a safety status level of the first user device, a subset of the previous location information of the first user device, and a subset of the previous location information of the second user device.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: October 12, 2021
    Assignee: THE SAFETY NETWORK PARTNERSHIP, LLC
    Inventors: Gary W. Grube, Evan Edward Quisenberry, John Edward Buchalo
  • Patent number: 11130931
    Abstract: A composition and a method for clearing tissue for subsequent three-dimensional analysis. The clearing composition comprises: (1) a homogenizing agent such as N-methylglucamine, urea, or ethylenediamine; (2) a cytoplasmic, water-soluble refractive index adjusting agent such as iohexol, sodium thiosulfate, or polyethylene glycol; and (3) a membrane, lipid-soluble RI adjusting agent such as 2,2?-thiodiethanol (TDE) or propylene glycol. The tissue clearing composition is particularly suitable for use with long-term fixed human tissues.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: September 28, 2021
    Assignee: THE UNIVERSITY OF HONG KONG
    Inventors: Hei Ming Lai, Wutian Wu
  • Patent number: 11098303
    Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: August 24, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaowei Zhuang, Kok-Hao Chen, Alistair Boettiger, Jeffrey R. Moffitt, Siyuan Wang
  • Patent number: 11071964
    Abstract: The present invention is related to an electrochemical reactor (1) and a microfluidic platform (20) comprising this reactor (1), controlling pH in a closed environment, wherein this reactor (1) comprises at least one cell (2), wherein each cell (2) containing at least one micro-well (3a) able to contain a liquid and reagents and a cap (7) to close the said cell (2) and wherein the cell (2) further comprises at least one working electrode (5) producing reversible REDOX reactions.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: July 27, 2021
    Assignee: LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)
    Inventors: Cesar Pascual Garcia, Mathieu Gerard, Jean Sebastien Thomann
  • Patent number: 11071977
    Abstract: A biological sample analysis device that is an easily portable free-standing device for determining the rate of deterioration of biological samples.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: July 27, 2021
    Inventor: William Brinton
  • Patent number: 11073524
    Abstract: The present invention provides methods, devices, and compositions to rapidly detect analytes, including small analytes, using a lateral flow device. Described herein is such a lateral flow device that can detect and quantify vitamin D in a whole blood, serum, or plasma sample by employing a sandwich-based immunoassay.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: July 27, 2021
    Assignee: Affimedix, Inc.
    Inventor: Kevin C. Wang
  • Patent number: 11060055
    Abstract: A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises: i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate being fusibly sealable to the bioreactor vessel at a hole in the wall thereof; ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: July 13, 2021
    Assignee: Finesse Solutions, Inc.
    Inventors: Mark Selker, Barbara Paldus, Timothy Johnston
  • Patent number: 11054408
    Abstract: The present subject matter discloses various exemplary projective capacitive micro structured electrode arrays for measuring the impedance and action potential of living cells in particular induced pluripotent stem cells that are subsequently differentiated into cardiomyocytes and neurons. In one exemplary system a projective capacitive electrode array with cardiomyocytes attached onto the electrodes is formed and electrical measurements of live cell responses when exposed to external stimulants, such as small molecule drugs or biologically active compounds is recorded.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: July 6, 2021
    Assignee: StemoniX Inc.
    Inventor: Robert John Petcavich
  • Patent number: 11035843
    Abstract: A method for evaluating the ability of cells to grow into a sheet includes (1) a step of examining cell cultures growing into a sheet to determine their impedance and/or electrical resistance or numerical values relating thereto; (2) a step of comparing the numerical values determined by Step (1) with reference values; and (3) a step of judging, based on the results of comparison obtained in Step (2), the ability of cells to grow into a sheet.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: June 15, 2021
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Ryohei Takeuchi, Kouichirou Yori
  • Patent number: 11028452
    Abstract: The present invention relates to a primer pair comprising a forward primer and a reverse primer for amplifying a nucleic acid from a pathogen associated with a skin, hair and nail infection comprising SEQ ID NO:22, a nucleic acid capable of hybridizing specifically to a nucleic acid sequence from a pathogen associated with a skin, hair and nail infection comprising SEQ ID NO:22, a carrier comprising the nucleic acid, a method comprising the step detecting in a sample a nucleic acid sequence comprising SEQ ID NO:22 from a pathogen associated with a skin, hair and nail infection, a use of the primer pair, the nucleic acid or the carrier for the diagnosis of a disease and a kit comprising the primer pair, the nucleic acid and/or the carrier for the diagnosis of a disease.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: June 8, 2021
    Assignee: EUROIMMUN Medizinische Labordiagnostika AG
    Inventors: Melanie Harder, Yvonne Graeser, Christiane Kupsch, Markus Cavalar
  • Patent number: 11021750
    Abstract: Biomarkers useful for the diagnosis and treatment of acute ischemic stroke are disclosed. Also provided is a quantitative assay method for accurately identifying transcript number in a biological sample.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: June 1, 2021
    Assignee: THE RESEARCH FOUNDATION FOR STATE UNIVERSITY OF NEWYORK
    Inventors: Alison E. Baird, Mateusz Adamski
  • Patent number: 11022550
    Abstract: The invention relates to a method for observing a sample (12), the sample (12) comprising a set of organisms (14), a solid substrate (16) supporting the set of organisms (14). The method being characterized in that the method includes steps for illuminating at least one portion of the sample (12) with a light beam, for acquiring a first diffraction pattern corresponding to an image of waves from the diffraction of the light beam by at least one portion of the set of organisms (14), for acquiring a second diffraction pattern corresponding to an image of waves from the diffraction of the light beam by at least one portion of the sample (12), for comparing the second diffraction pattern with the first diffraction pattern, for determining at least one characteristic relating to the set of organisms (14) from the result of the comparison step.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: June 1, 2021
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, BIOMERIEUX
    Inventors: Pierre Marcoux, Mathieu Dupoy
  • Patent number: 11002732
    Abstract: Disclosed is method of improving flow of a liquid sample in an assay device, as well as a method of performing an assay on a liquid sample for the detection of one or more analytes of interest. The methods use the addition of a reagent, such as a wash reagent, to wet the fluid flow path of a sample prior to sample addition, thereby improving flow of the sample through the fluid flow path that has been wetted as opposed to flow of the sample through the fluid flow path that has not been wetted. The reagent wets the fluid flow path between the sample addition zone and the wicking zone.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: May 11, 2021
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Zhong Ding, Philip C. Hosimer, Edward Scalice
  • Patent number: 10994271
    Abstract: The present invention provides a membrane carrier 3 for a test kit of detecting a target substance in a liquid sample, comprising at least one flow path 2 transporting the liquid sample, wherein a microstructure producing capillary action for transporting the liquid sample is formed at a bottom of the flow path 2, and the microstructure is provided to change along a transport direction d of the liquid sample.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: May 4, 2021
    Assignee: Denka Company Limited
    Inventors: Yuto Akiyama, Kenji Monden
  • Patent number: 10988723
    Abstract: The present invention relates to modular assemblies and systems for conducting cell analyses. In particular embodiments, an assembly has micron-scale fluidic structures, thereby minimizing sample use, and possesses a modular architecture that facilitates disassembly of the apparatus. Thus, one such modular assembly facilitates on-chip cell growth and on-chip assays; and then, as needed, the assembly can be disassembled to provide direct access to the cells that were incubated and treated within the chip. Methods of making and using such assemblies, as well as systems thereof, are further described herein.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: April 27, 2021
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Anson Hatch, Vinay Abhyankar, Chung-Yan Koh
  • Patent number: 10969390
    Abstract: A method for evaluating an efficacy of a chemoradiotherapy against squamous cell carcinoma comprises the following steps (a) to (c): (a) detecting an expression level of at least one gene selected from a SIM2 gene and genes co-expressed with the SIM2 gene in a squamous cell carcinoma specimen isolated from a subject; (b) comparing the expression level detected in the step (a) with a reference expression level of the corresponding gene; and (c) determining that an efficacy of a chemoradiotherapy against squamous cell carcinoma in the subject is high if the expression level in the subject is higher than the reference expression level as a result of the comparison in the step (b).
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: April 6, 2021
    Assignees: NATIONAL CANCER CENTER, KYOTO UNIVERSITY, OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Hiroki Sasaki, Kazuhiko Aoyagi, Manabu Muto, Hiroo Takahashi
  • Patent number: 10961492
    Abstract: A microfluidic device for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs that includes a culture chamber may include: a confinement apparatus configured to define at least one compartment configured to contain a cellular matrix and at least one compartment configured to contain a culture medium, the confinement apparatus being hydrophobic and pervious to the culture medium; and/or at least one counter element. The confinement apparatus and at least one counter element may be reciprocally mobile between resting and compression positions of the cellular matrix. A method for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs at a microscale may include: controlled compression of a cellular matrix for a predetermined period of time. The cellular matrix may be delimited by a confinement apparatus that is pervious to a culture medium.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 30, 2021
    Assignees: POLITECNICO DI MILANO, FONDAZIONE CARIPLO
    Inventors: Alberto Redaelli, Marco Rasponi, Paola Occhetta
  • Patent number: 10955351
    Abstract: An adaptation device is provided for adapting an UV-Vis cuvette to perform in-situ spectroanalytical characterization of redox processes using gas species or solutes in a controlled atmosphere, the device configured to fit the open end of a UV-Vis cuvette intended to contain products to be measured during achievement of spectroanalytical measurements. The device comprises a main body configured to form a lid covering the opened end of the cuvette, the main body having a first part and a second part; a working, a counter and a reference electrode with removable parts at the respective ends of three conductors coming from outside and passing through the main body; a gas inlet to allow introduction of a gas the gas inlet having one aperture directed to the working electrode and second aperture directed to the bottom of the cuvette, a gas outlet intended to let the reactive gas in excess to flow out of the cuvette and an solution inlet tube for titration measurements.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: March 23, 2021
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Lukas Lutz, Daniel Alves Dalla Corte, Alexis Grimaud, Jean-Marie Tarascon
  • Patent number: 10921237
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: February 16, 2021
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10914751
    Abstract: A sample is measured using a cartridge from a batch comprising a plurality of cartridges of the same type. The measurement results measured in the process are evaluated. In order to evaluate the measurement results, reference results are used in addition, which reference results were measured previously, separately, during measurements of reference samples, using a plurality of cartridges of the same batch. An analyte of the sample is determined from the measurement results. During the evaluation, the reference results and/or measurement results are preferably normalized.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: February 9, 2021
    Assignee: BOEHRINGER INGELHEIM VETMEDICA GMBH
    Inventor: Matthias Griessner
  • Patent number: 10908090
    Abstract: The invention describes generating and use of a multi-layer plasmonic slide, wherein the plasmonic slide comprises at least 6 layers of metallic nanoparticles that can enhance the detection of fluorescent signals and wherein the plasmonic slide can be printed as a microarray of any size. The microarray containing the plasmonic slide can further be printed with a protein, a glycan, or an antibody. The multi-layer plasmonic slide is capable of detecting proteins, polynucleotides, and/or glycans at orders of magnitude lower concentration than non-plasmonic substrates.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: February 2, 2021
    Inventor: Chris Geddes
  • Patent number: 10877041
    Abstract: The present disclosure provides methods for detecting biological print(s) or biological fluid(s) or target low molecular weight analyte(s) therein comprising contacting the suspected print(s) or fluid(s) with porous semiconductor substrates or microparticles (MPs) under conditions to allow said semiconductor substrates or microparticles to adhere to the print(s) or fluid(s) or analyte(s) therein, and analysing the adhered porous semiconductor substrates or MPs to detect the print(s), fluid(s) or analytes when present. The disclosure also includes method for making porous semiconductor substrates.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: December 29, 2020
    Inventor: Nicolas H. Voelcker
  • Patent number: 10859570
    Abstract: The present invention relates to an analyte detection device comprising: a sample chamber for storing a mixture solution of a sample comprising an analyte and a reactant comprising particles; a detection chamber for storing a detection solution; and a channel placed between the sample chamber and the detection chamber to prevent the mixture solution and the detection solution from being mixed with each other, the analyte detection device characterized by detecting the analyte by moving the particles from the sample chamber to the detection chamber using moving means.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: December 8, 2020
    Inventor: Suk-Jung Choi
  • Patent number: 10837960
    Abstract: An assay device including a loading zone for a sample that may contain an analyte, an activator in communication with the loading zone from which at least one activator is displaced by presence of the analyte, an amplifier in an inactive state in communication with the activator that becomes activated in the presence of the activator, a biomatrix barrier in communication with the activated amplifier that is degraded or modified by the activated amplifier, and an indicator responsive to the degradation or modification of the biomatrix barrier, which in turn reflects a concentration of the analyte in the sample loaded on the device. The selection of analyte or displacement of the activator by presence of the analyte may occur off-platform and/or may rely on use of non-covalent interactions. The activator may include an enzyme or other reagent that activates the amplifier. Also, associated methods.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: November 17, 2020
    Assignee: CALIFORNIA POLYTECHNIC STATE UNIVERSITY
    Inventors: Nathaniel Martinez, Andres Martinez
  • Patent number: 10808282
    Abstract: Substrates comprising dual functional polymer layered surfaces and the preparation thereof by using UV nano-imprinting processes are disclosed. The substrates can be used as flow cells, nanofluidic or microfluidic devices for biological molecules analysis.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: October 20, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Andrew A. Brown, Wayne N. George, Alexandre Richez, M. Shane Bowen
  • Patent number: 10794817
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: October 6, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10782226
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: September 22, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10758573
    Abstract: The present invention is directed to a device for enriching cells with a cell surface marker, comprising an aptamer suitable for specifically binding the cell surface marker, and beads coupled thereto, wherein the aptamer is coupled to the beads in a manner that allows for release of cells expressing the cell surface marker, in the absence of a chemical agent, and production of a cell population enriched for cells expressing the cell surface marker, substantially free of beads and aptamer. Kits comprising the device or components thereof, and methods of cell enrichment, are also provided. In exemplary embodiments, the device contains an aptamer that specifically binds CD31.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: September 1, 2020
    Assignees: President and Fellows of Harvard College, CHARITÉUNIVERSITÄTSMEDIZIN BERLIN
    Inventors: Pascal Joly, Georg N. Duda, Thomas Schaus, Anke Dienelt, Andrea Sass, David J. Mooney
  • Patent number: 10746648
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: August 18, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10736536
    Abstract: One embodiment of the present application sets forth a method for predicting recurrence of cancerous cells in a patient that includes measuring, by a first subset of electrodes included in an electrode array operating at a first frequency, a first impedance of a first section of a first sample of tissue excised from the patient, computing a first Cole relaxation frequency for the first section of the first sample based on the first impedance, and generating a first prediction relating to cancerous cells in the patient based at least in part on the first Cole relaxation frequency.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: August 11, 2020
    Assignee: NOVASCAN, INC.
    Inventor: William David Gregory
  • Patent number: 10725019
    Abstract: Example implementations relate to coagulation sensing. For example, a microfluidic chip for coagulation sensing may include a microfluidic channel, an outlet at an end of the microfluidic channel having an air interface, and an impedance sensor located within the microfluidic channel and within a particular proximity to the air interface, the impedance sensor to determine a stage of a coagulation cascade of a blood sample flowing through the microfluidic channel to the impedance sensor.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: July 28, 2020
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Melinda M Valencia, Chantelle E Domingue, Jeremy Sells, Manish Giri, Sadiq Bengali
  • Patent number: 10723992
    Abstract: The present disclosure provides a culture device for enumerating colonies of microorganisms. The device can comprise a base, a coversheet, and a nonporous spacer member disposed therebetween. The spacer member comprises an aperture that defines a growth compartment. At least one adhesive layer is adhered to the base or the coversheet in the growth compartment. A cold water-soluble gelling agent and an effective amount of a dry carbon dioxide-generating reagent are adhered to the at least one adhesive layer. The carbon dioxide-generating reagent consists essentially of particles having a diameter of less than 106 microns.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: July 28, 2020
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Jason W. Bjork, Evan D. Brutinel, Adam J. Stanenas
  • Patent number: 10718872
    Abstract: A photonic dosimeter accrues cumulative dose and includes: a substrate; a waveguide disposed on the substrate and that: receives a primary input light; transmits secondary input light from the primary input light to a dosimatrix; receives a secondary output light from the dosimatrix; and produces primary output light from the secondary output light; the dosimatrix disposed on the substrate and in optical communication with the waveguide and that: receives the secondary input light from the waveguide; produces the secondary output light that is communicated to the waveguide; and includes an active element that undergoes conversion from a prime state to a dosed state in response to receipt, by the active element, of a dose of radiation; and a cover layer disposed on waveguide and the dosimatrix.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: July 21, 2020
    Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS RESPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Ronald Tosh, Zeeshan Ahmed, Ryan P. Fitzgerald, Nikolai Klimov
  • Patent number: 10675724
    Abstract: A mobile system and method for separating lubricants from swarf material streams provides on-site recovery of lubricants in an efficient, effective, sustainable and economic manner. The system thus reduces the need to transport relatively large volumes of swarf and lubricant material stream to a remote location for disposal. The system includes swarf of various types, for example, aluminum, steel, precious metals, plastic, etc. mixed with various water based or oil based lubricants. A trailer or motor vehicle containing a power supply, a basket centrifuge(s) connected to the power supply for powered operation thereof, a live bottom conveyor for supplying swarf to the centrifuges, a portable feed hopper with attached augers for supplying swarf to the live bottom conveyor, a bag liner to filter the extracted lubricant as it exits the basket, a crane for lifting the bag liner out of the basket, a container to accumulate the dried swarf, a container to accumulate the extracted lubricant.
    Type: Grant
    Filed: May 6, 2018
    Date of Patent: June 9, 2020
    Inventor: Justin Edmondson
  • Patent number: 10670490
    Abstract: The present invention relates to a method for a measurement system configured to test a flexible bio-process bag, the method comprising providing at least one flexible bio-process bag having a volume, wherein the at least one flexible bio-process bag is initially filled with a gas and inflated to a reference pressure (Pu), obtaining a leak model, obtaining baseline information, wherein the baseline information comprises at least a weighed first mass value (mbaseline) and a first time value (t1), obtaining evaluation information, wherein the evaluation information comprises at least a weighed second mass value (mevaluation) and a second time value (t2), testing the flexible bio-process bag based on the leak model, the baseline information and the evaluation information.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: June 2, 2020
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Robert Douglas Burchesky, James Molloy