Including Measuring Or Testing Patents (Class 435/287.1)
  • Patent number: 10723992
    Abstract: The present disclosure provides a culture device for enumerating colonies of microorganisms. The device can comprise a base, a coversheet, and a nonporous spacer member disposed therebetween. The spacer member comprises an aperture that defines a growth compartment. At least one adhesive layer is adhered to the base or the coversheet in the growth compartment. A cold water-soluble gelling agent and an effective amount of a dry carbon dioxide-generating reagent are adhered to the at least one adhesive layer. The carbon dioxide-generating reagent consists essentially of particles having a diameter of less than 106 microns.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: July 28, 2020
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Jason W. Bjork, Evan D. Brutinel, Adam J. Stanenas
  • Patent number: 10725019
    Abstract: Example implementations relate to coagulation sensing. For example, a microfluidic chip for coagulation sensing may include a microfluidic channel, an outlet at an end of the microfluidic channel having an air interface, and an impedance sensor located within the microfluidic channel and within a particular proximity to the air interface, the impedance sensor to determine a stage of a coagulation cascade of a blood sample flowing through the microfluidic channel to the impedance sensor.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: July 28, 2020
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Melinda M Valencia, Chantelle E Domingue, Jeremy Sells, Manish Giri, Sadiq Bengali
  • Patent number: 10718872
    Abstract: A photonic dosimeter accrues cumulative dose and includes: a substrate; a waveguide disposed on the substrate and that: receives a primary input light; transmits secondary input light from the primary input light to a dosimatrix; receives a secondary output light from the dosimatrix; and produces primary output light from the secondary output light; the dosimatrix disposed on the substrate and in optical communication with the waveguide and that: receives the secondary input light from the waveguide; produces the secondary output light that is communicated to the waveguide; and includes an active element that undergoes conversion from a prime state to a dosed state in response to receipt, by the active element, of a dose of radiation; and a cover layer disposed on waveguide and the dosimatrix.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: July 21, 2020
    Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS RESPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Ronald Tosh, Zeeshan Ahmed, Ryan P. Fitzgerald, Nikolai Klimov
  • Patent number: 10675724
    Abstract: A mobile system and method for separating lubricants from swarf material streams provides on-site recovery of lubricants in an efficient, effective, sustainable and economic manner. The system thus reduces the need to transport relatively large volumes of swarf and lubricant material stream to a remote location for disposal. The system includes swarf of various types, for example, aluminum, steel, precious metals, plastic, etc. mixed with various water based or oil based lubricants. A trailer or motor vehicle containing a power supply, a basket centrifuge(s) connected to the power supply for powered operation thereof, a live bottom conveyor for supplying swarf to the centrifuges, a portable feed hopper with attached augers for supplying swarf to the live bottom conveyor, a bag liner to filter the extracted lubricant as it exits the basket, a crane for lifting the bag liner out of the basket, a container to accumulate the dried swarf, a container to accumulate the extracted lubricant.
    Type: Grant
    Filed: May 6, 2018
    Date of Patent: June 9, 2020
    Inventor: Justin Edmondson
  • Patent number: 10670490
    Abstract: The present invention relates to a method for a measurement system configured to test a flexible bio-process bag, the method comprising providing at least one flexible bio-process bag having a volume, wherein the at least one flexible bio-process bag is initially filled with a gas and inflated to a reference pressure (Pu), obtaining a leak model, obtaining baseline information, wherein the baseline information comprises at least a weighed first mass value (mbaseline) and a first time value (t1), obtaining evaluation information, wherein the evaluation information comprises at least a weighed second mass value (mevaluation) and a second time value (t2), testing the flexible bio-process bag based on the leak model, the baseline information and the evaluation information.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: June 2, 2020
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Robert Douglas Burchesky, James Molloy
  • Patent number: 10669579
    Abstract: A sensing device includes a stack of dielectric layers having conductive materials disposed between the dielectric layers. A nanopore is disposed through the stacks of dielectric layers and separates the conductive materials to provide electrodes on opposite sides of the nanopore. Contacts connect to each of the electrodes.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: June 2, 2020
    Assignee: International Business Machines Corporation
    Inventors: Zhenxing Bi, Kangguo Cheng, Juntao Li, Xin Miao
  • Patent number: 10656116
    Abstract: A microbial sensor, system, and method that can be used to determine a chemical environment and/or substrate concentrations in anaerobic or aerobic environments, such as soils, sediments and ground waters, are disclosed. An exemplary system uses one or more (e.g., inert) measurement electrodes and a reference electrode. The reference electrode can include an electrode exposed to atmospheric oxygen (e.g., a cathode) or an electrode exposed to stable anaerobic or aerobic conditions. The exemplary microbial sensor system measures open-circuit voltage to characterize the chemical (oxidizing or reducing) environment and/or recovery voltage to measure substrate concentrations in the subsurface.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: May 19, 2020
    Inventors: Scott R. Burge, Russell G. Burge, David A. Hoffman
  • Patent number: 10655166
    Abstract: Apparatus and methods are disclosed for electrically active combinatorial-chemical (EACC) chips for biochemical analyte detection. An apparatus includes a substrate that has an array of regions defining multiple cells, wherein each of the cells includes a reaction cavity that contains multiple functional binding groups. A method of detecting an analyte providing the reaction cavity between a source and a drain or a pair of electrodes, applying a voltage and monitoring a parameter indicative of an analyte characteristic. A process of fabricating an EACC include bonding an analyte to the multiple functional binding groups of each reaction cavity, and forming an analyte sensing structure including the substrate.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: May 19, 2020
    Assignee: Intel Corporation
    Inventors: Xing Su, Lei B. Sun, Jacque H. Georger, Jr.
  • Patent number: 10641700
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: May 5, 2020
    Assignee: Celsee Diagnostics, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10591404
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: March 17, 2020
    Assignee: Celsee Diagnostics, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10572996
    Abstract: A method for annotating a tissue slide image, a system and a method performed by a computing system for detecting pathological anomalies in a digital pathology image are disclosed. The method performed by a computing system for detecting pathological anomalies in a digital pathology image includes providing a digital pathology image to the computing system and analyzing the digital pathology image using an identification module arranged on the computing system. The identification module uses a machine learning module to execute recognizing an object containing an abnormal image pattern using an identification model loaded in said identification module and identifying whether the abnormal image pattern corresponds to a pathological anomaly using the identification model.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: February 25, 2020
    Assignee: CONTEXTVISION AB
    Inventor: Kristian Eurèn
  • Patent number: 10533936
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: January 14, 2020
    Assignee: Celsee Diagnostics, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10489104
    Abstract: A method and apparatus for generating harmonics using polynomial non-linear functions. Polynomial functions are used to produce harmonics of an input signal up to a predetermined order, and that match a preferred set of characteristics. The preferred characteristics include approximating a sine function to generate odd harmonics, and using a function with zero slope at ?1, 0, and +1 to generate even harmonics. The polynomial coefficients may be chosen such that most of the coefficients for the odd polynomial function are scaled by the same constant as the coefficients for the even polynomial function, so that the calculation is shared between the two polynomials. In one embodiment, a digital signal processor having a pipelined ALU and a MAC is used to calculate the desired polynomial non-linear functions.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: November 26, 2019
    Assignee: TEMPO SEMICONDUCTOR, LLC
    Inventor: Darrell Eugene Tinker
  • Patent number: 10480034
    Abstract: The application discloses new biomarkers and methods useful in the diagnosis, prognosis and/or monitoring of, or as a therapeutic or research target for, solid tumour cancers, such as colorectal cancer, based on measuring the biomarkers; and related kits and devices.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: November 19, 2019
    Inventor: Jeffrey Lordan
  • Patent number: 10468135
    Abstract: A system for automatically detecting and displaying sepsis images in a hospital system is described herein. In some examples, the system can include receiving data related to a plurality of physiological parameters from a patient over time, and identifying and organizing patterns of perturbations of the data. The system can also include analyzing the perturbations to identify known relational physiologic patterns and detecting a pattern of sepsis, the pattern being comprised of a plurality of perturbations and/or relational physiologic patterns. Furthermore, the system can include organizing and synthesizing the plurality of relational physiologic patterns into a set of sepsis images, which as an aggregate whole make up an image representation of the complex and dynamic state of sepsis, and displaying the sepsis images. The images can be color motion images of cascades which display the severities of individual perturbations and relational physiologic patterns along the cascade pattern.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: November 5, 2019
    Inventor: Lawrence A. Lynn
  • Patent number: 10465158
    Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: November 5, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Donald E. Ingber, Daniel Levner, Guy Thompson, II, Jose Fernandez-Alcon, Christopher David Hinojosa
  • Patent number: 10441205
    Abstract: An arrangement includes a housing, a plurality of sampling and analysis sites contained within the housing, each of the sampling and analysis sites having a skin-penetration member having a first end configured to pierce the skin, and an inner lumen in communication with the first end, an actuator operatively associated with the skin-penetration member, and an analyte quantification member in fluid communication with the inner lumen of the skin-penetration member. Integrated devices including such arrangements are also described.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: October 15, 2019
    Assignee: Intuity Medical, Inc.
    Inventors: Craig M. Litherland, Jeffrey L. Emery, Raul Escutia, James W. Pfeiffer, Jeffrey M. Jones
  • Patent number: 10436700
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: October 8, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Pridyadarshini Gogoi, Christopher Siemer, Saedeh Sepehri Javdani
  • Patent number: 10416070
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: September 17, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10417938
    Abstract: The invention relates to a digestion system for analyzing the intestinal fluid. The system comprises a compartment containing the fluid content and a micro filter for filtering particles in the fluid content having a size beyond the micro range. The system further comprises a pertractor arranged downstream to the micro filter for removing digested lipophilic particles.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: September 17, 2019
    Assignee: Triskelion B.V.
    Inventor: Mans Minekus
  • Patent number: 10408736
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: September 10, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventor: Kalyan Handique
  • Patent number: 10408737
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: September 10, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Pridyadarshini Gogoi, Christopher Siemer, Saedeh Sepehri Javdani
  • Patent number: 10369573
    Abstract: Biological reagent carrier devices and methods are disclosed, which employ RFID techniques to associate information with biological reagents.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: August 6, 2019
    Assignee: Applied Biosystems, LLC
    Inventors: Richard D. Morris, Jerome A. Mack
  • Patent number: 10364411
    Abstract: A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: July 30, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Nancy Allbritton, Yuli Wang, Christopher Sims
  • Patent number: 10358641
    Abstract: Provided herein are monoliths with attached recognition compounds which selectively bind ligands, methods of preparing such monoliths, arrays thereof and uses thereof. For example, monoliths provide herein can be used in columns and arrays thereof.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: July 23, 2019
    Assignee: DiCE Molecules SV, LLC
    Inventors: Pehr Harbury, Madan Paidhungat, Robin Prince
  • Patent number: 10343163
    Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: July 9, 2019
    Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College, Vilnius University
    Inventors: Joseph Italiano, Linas Mazutis, Jonathan N. Thon, David A. Weitz
  • Patent number: 10345219
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: July 9, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Priyadarshini Gogoi, Christopher Siemer, Saedeh Sepehri Javdani
  • Patent number: 10338056
    Abstract: An apparatus for supporting an array of layers of amphiphilic molecules, the apparatus comprising: a body (11), formed in a surface of the body, an array of sensor wells (10) capable of supporting a layer of amphiphilic molecules (30) across the sensor wells, the sensor wells each containing an electrode (12) for connection to an electrical circuit, and formed in the surface of the body between the sensor wells, flow control wells capable of smoothing the flow of a fluid across the surface.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: July 2, 2019
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Jason Robert Hyde, James Anthony Clarke, Gaëlle Anne-Leonie Andreatta
  • Patent number: 10330218
    Abstract: A gating mechanism that uses a capillary stabilized liquid as a reversible, reconfigurable gate that fills and seals pores in the closed state, and creates a non-fouling, liquid-lined pore in the open state is disclosed. Theoretical modeling and experiments demonstrate that for each transport substance, the gating threshold—the pressure needed to open the pores—can be rationally tuned over a wide pressure range. This enables realizing in one system differential response profiles for a variety of liquids and gases, even letting liquids flow through the pore while preventing gas from escaping. These capabilities allow dynamic modulation of gas-liquid sorting and to separate multi-phase mixtures, with the liquid lining ensuring sustained antifouling behavior.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: June 25, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Joanna Aizenberg, Xu Hou, Mughees Khan, Alexander Tesler
  • Patent number: 10328062
    Abstract: The present invention relates to methods of therapeutic treatment of cancer using selective tyrosine kinase inhibitors and cancer biomarkers, such as MET amplification and high Met expression for patient selection.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: June 25, 2019
    Assignee: Amgen, Inc.
    Inventors: Sean Caenepeel, Angela Coxon, Zhiqiang Du, Paul Hughes, Robert Loberg, Gataree Ngarmchamnanrith, Beate Sable
  • Patent number: 10316357
    Abstract: Compositions and methods for enhanced adapter ligation are provided. The compositions and methods can be useful for next generation sequencing (NGS) library preparation and can result in higher yields in an NGS library.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: June 11, 2019
    Assignee: Swift Biosciences, Inc.
    Inventors: Vladimir Makarov, Julie Laliberte
  • Patent number: 10302573
    Abstract: One example of the present disclosure relates to an apparatus for spectroscopic analysis of residue. The apparatus includes a surface including a hydrophobic portion and a hydrophilic portion. The hydrophobic portion surrounds the hydrophilic portion. The hydrophilic portion includes a dimension equal to or larger than a width of a first incident non-destructive electromagnetic beam.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: May 28, 2019
    Assignee: The Boeing Company
    Inventor: Paul G. Vahey
  • Patent number: 10280077
    Abstract: Aspects include a method of manufacturing a flexible electronic structure that includes a metal or doped silicon substrate. Aspects include depositing an adhesive layer on the top side of the structure. Aspects also include depositing a release layer and a glass layer on the top side of the structure. Aspects also include reducing a thickness of the silicon substrate on the bottom side of the structure.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: May 7, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Paul S. Andry, Huan Hu, Katsuyuki Sakuma
  • Patent number: 10281419
    Abstract: A hydrogel-based interdigitated microelectrode biosensor is disclosed. The hydrogel-based interdigitated microelectrode biosensor includes: a first interdigitated microelectrode having a plurality of first protrusion electrodes arranged in a comb-like shape on a substrate; a second interdigitated microelectrode facing the first interdigitated microelectrode and having a plurality of second protrusion electrodes arranged in a comb-like shape on the substrate, the second protrusion electrodes being arranged alternately with the first protrusion electrodes of the first interdigitated microelectrode; and a hydrogel filled in a space between the first and second interdigitated microelectrodes arranged alternately with each other. The hydrogel is provided between the interdigitated microelectrodes such that the presence and concentration of a biological substance, such as a protein, are detected by measuring the impedance between the interdigitated microelectrodes.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: May 7, 2019
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Kyoseon Hwang, Nakwon Choi, Jinsik Kim, Hye Jin Kim, Yong Kyoung Yoo, Sang Yun Yeom, Woongsun Choi
  • Patent number: 10274504
    Abstract: Disclosed is a microcapsule encoded depending on the kind of a target substance included therein. The encoded microcapsule has a hydrophilic liquid core including the target substance and a hydrophobic shell surrounding the liquid core. The encoded microcapsule includes graphical codes introduced on the surface of the shell.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: April 30, 2019
    Assignee: QUANTAMATRIX INC.
    Inventors: Sunghoon Kwon, Younghoon Song, Taehong Kwon, Daewon Lee, Junhoi Kim
  • Patent number: 10266403
    Abstract: The invention relates to a microarray design of hybrid upconversion nanoparticles on a nanoporous anodized alumina membrane heterogeneous assay for simultaneous detection of multiple oligonucleotides, for example, oligonucleotides from different types of viruses.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: April 23, 2019
    Assignee: The Hong Kong Polytechnic University
    Inventors: Jianhua Hao, Mo Yang, Ming-Kiu Tsang, Weiwei Ye
  • Patent number: 10213140
    Abstract: The present invention described a system for an energized ophthalmic device with a media insert that includes microfluidic elements upon or within the media insert. In some embodiments, the microfluidic elements may be useful for the purpose of analyzing an analyte such as glucose in a fluid sample. In addition, some embodiments can function with a medicament administering device to treat an abnormal condition identified during the analyte analysis in the fluid sample.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: February 26, 2019
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Randall B. Pugh, Frederick A. Flitsch, Karson S. Putt
  • Patent number: 10208284
    Abstract: Provided is a device for seeding cells in a plurality of cell arrangement areas in a simple manner and a short period of time. A seeding and culturing device (1) for cells capable of forming a nerve network, the device comprising a cell-culturing substrate (2) having a plurality of cell arrangement areas (8) enclosed by a plurality of projecting parts, and a flow channel substrate (3) arranged on the cell-cultivating substrate (2) and having a plurality of through-holes (14), wherein the through-holes (14) are configured so as to provide flow channels in which the upper surface side of the substrate is an entrance (15) and the lower surface side of the substrate is an exit, and the exit (16) of the flow channels is positioned above any of the cell arrangement areas.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: February 19, 2019
    Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Tsuneo Urisu, Zhi-hong Wang, Hidetaka Uno, Yasutaka Nagaoka
  • Patent number: 10202575
    Abstract: A system (1) is provided for switching over exhaust air of a bioreactor (2) that has a disposable container (3). The system (1) has at least two exhaust air ducts (4, 5) connecting the disposable container (3) to exhaust air filters (6, 7, 18, 18?). A valve (8) is disposed in at least one of the at least two exhaust air ducts (4, 5) and enables the associated exhaust air filter (6, 7, 18, 18?) to be freed.
    Type: Grant
    Filed: March 22, 2014
    Date of Patent: February 12, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Wolfgang Kahlert, Ralf Hartmann, Bernward Husemann
  • Patent number: 10190965
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: January 29, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Priyadarshini Gogoi, Christopher Siemer, Saedeh Sepehri Javdani
  • Patent number: 10138523
    Abstract: The application discloses new biomarkers and methods useful in the diagnosis, prognosis and/or monitoring of, or as a therapeutic or research target for, solid tumor cancers, such as colorectal cancer, based on measuring the biomarkers; and related kits and devices.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: November 27, 2018
    Inventor: Jeffrey Lordan
  • Patent number: 10119965
    Abstract: The present invention relates to devices for conducting microorganism or toxin detection. More particularly, the invention relates to portable, pre-packaged devices that are suitable for culturing microorganisms, aliquoting predetermined volumes of testing samples, and conducting microorganism or toxin detection based on immunological reactions using samples of considerable size collected at remote sites away from testing laboratories.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: November 6, 2018
    Assignee: FUNDACION GAIKER
    Inventors: Jose Luis Gondra Zubieta, Paloma Aldamiz-Echebarria Zulueta, Javier Escobal Gonzalo, Miren Garbine Olabarria De Pablo, Armando Cruz Llosa, Jesus Berganza Granda, Brigitte Michele Jacqueline Sauvage
  • Patent number: 10094818
    Abstract: A method for characterising cells or cell structures in a sample comprising: obtaining at least one normalized impedance response of the sample over at least one frequency range; and characterising at least one cell using at least one characteristic of the normalized impedance response.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: October 9, 2018
    Assignee: University of Strathclyde
    Inventors: Patricia Connolly, Laurie Shedden
  • Patent number: 10087582
    Abstract: The present invention is in the field of paper production, more in particular it relates to the process of wood pulping. It provides useful biological methods and compounds for reducing the energy requirements of the production of wood pulp. It describes a method for reducing the energy requirement of a thermo-mechanical pulping (TMP) process wherein cellulose fibers are recovered from a biomass comprising lignocellulosic material, wherein the lignocellulosic material is treated with a CotA laccase before recovering the cellulose from the lignocellulosic material.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: October 2, 2018
    Assignee: METGEN OY
    Inventors: Klara Birikh, Alexey Azhayev
  • Patent number: 10088494
    Abstract: Methods and systems for reducing the run-to-run variability in measurement results obtained by a sample analysis system. The method and system utilize data from previous sample runs to optimize analysis parameters for future test runs. The methods and systems are particularly suitable for microfluidic sample analysis.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: October 2, 2018
    Assignee: PERKINELMER HEALTH SCIENCES, INC.
    Inventors: Laurel Provencher, Jingjing Wang, I-Jane Chen, David Weinberger, Wael Yared
  • Patent number: 10072050
    Abstract: The present invention relates to chromatography ligands having improved caustic stability, e.g., ligands based on immunoglobulin-binding proteins such as, Staphylococcal protein A, as well as methods of making and using such ligands.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: September 11, 2018
    Assignee: EMD Millipore Corporation
    Inventors: Nanying Bian, Neil Soice, Shari Spector, Kara Levine
  • Patent number: 10041113
    Abstract: Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: August 7, 2018
    Assignee: Applied Biosystems, LLC
    Inventors: Linda G. Lee, Sam L. Woo, Congcong Ma, Richard T. Reel, Mark F. Oldham, David M. Cox, Benjamin G. Schroeder, Jon M. Sorenson, Willy Wiyatno
  • Patent number: 10031132
    Abstract: The invention relates to a method and a device for the detection of magnetic particles (1) in a sample chamber (112). After introduction of the sample into said sample chamber (112), the magnetic particles (1) are first retained within the sample chamber (112) and kept away from the sensing surface (111) by an appropriate magnetic field (B) to allow for an incubation of the sample with reagents. A reference measurement may be made during this incubation period (TI), preferably at the end thereof. After incubation, the magnetic particles (1) are allowed to contact the sensing surface (111) where a target measurement can be conducted.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: July 24, 2018
    Assignee: Minicare B.V.
    Inventors: Sytske Foppen, Bernardus Jozef Maria Beerling, Willemina Maria Huijnen-Keur, Hendrik Jan De Graaf, Danielle Walthera Maria Kemper-Van De Wiel, Roland Antonius Johannes Gerardus Smits, Albert Hendrik Jan Immink, Femke Karina De Theije, Wendela Meertens
  • Patent number: 10024794
    Abstract: Nickel, iron and palladium thin films thermally evaporated onto glass supports are used to demonstrate surface plasmon coupled fluorescence (SPCF) and surface plasmon couple chemiluminescence (SPCC) over a broad wavelength range (400-800 nm) for potential assays or other detection systems. Nickel, iron and palladium thin films used in SPCF and SPCC convert otherwise isotropic emission into highly directional and polarized emission, an attractive concept for surface assays. The emission angles of detected emissions occur over a 10 degree range for tested emitted wavelengths.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: July 17, 2018
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventor: Chris D. Geddes
  • Patent number: 10005999
    Abstract: An apparatus and method of measuring biofilm and biological activity on a surface is disclosed. The apparatus includes a biofilm, which includes one or more microorganisms, grown on a substrate. A viewing window is placed on a surface of the biofilm and a gas bubble is introduced between the viewing window and the surface of the biofilm. The space between the substrate and the viewing window may be enclosed in a casing that has an inlet and an outlet, forming a flow cell. A microscope system, such as a white light interferometer, captures data of the biofilm in situ and non-destructively. The 3D images of biofilm surface have high resolution while maintaining a large field of view. The apparatuses and methods will be useful for fundamental studies of biofilms, biomedical and environmental screening, and many other applications in biology and the life sciences.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: June 26, 2018
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Curtis J. Larimer, Jonathan D. Suter, Raymond S. Addleman, George T. Bonheyo, Michelle R. Brann