Including Measuring Or Testing Patents (Class 435/287.1)
  • Patent number: 10369573
    Abstract: Biological reagent carrier devices and methods are disclosed, which employ RFID techniques to associate information with biological reagents.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: August 6, 2019
    Assignee: Applied Biosystems, LLC
    Inventors: Richard D. Morris, Jerome A. Mack
  • Patent number: 10364411
    Abstract: A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: July 30, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Nancy Allbritton, Yuli Wang, Christopher Sims
  • Patent number: 10358641
    Abstract: Provided herein are monoliths with attached recognition compounds which selectively bind ligands, methods of preparing such monoliths, arrays thereof and uses thereof. For example, monoliths provide herein can be used in columns and arrays thereof.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: July 23, 2019
    Assignee: DiCE Molecules SV, LLC
    Inventors: Pehr Harbury, Madan Paidhungat, Robin Prince
  • Patent number: 10345219
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: July 9, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Priyadarshini Gogoi, Christopher Siemer, Saedeh Sepehri Javdani
  • Patent number: 10343163
    Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: July 9, 2019
    Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College, Vilnius University
    Inventors: Joseph Italiano, Linas Mazutis, Jonathan N. Thon, David A. Weitz
  • Patent number: 10338056
    Abstract: An apparatus for supporting an array of layers of amphiphilic molecules, the apparatus comprising: a body (11), formed in a surface of the body, an array of sensor wells (10) capable of supporting a layer of amphiphilic molecules (30) across the sensor wells, the sensor wells each containing an electrode (12) for connection to an electrical circuit, and formed in the surface of the body between the sensor wells, flow control wells capable of smoothing the flow of a fluid across the surface.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: July 2, 2019
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Jason Robert Hyde, James Anthony Clarke, Gaëlle Anne-Leonie Andreatta
  • Patent number: 10330218
    Abstract: A gating mechanism that uses a capillary stabilized liquid as a reversible, reconfigurable gate that fills and seals pores in the closed state, and creates a non-fouling, liquid-lined pore in the open state is disclosed. Theoretical modeling and experiments demonstrate that for each transport substance, the gating threshold—the pressure needed to open the pores—can be rationally tuned over a wide pressure range. This enables realizing in one system differential response profiles for a variety of liquids and gases, even letting liquids flow through the pore while preventing gas from escaping. These capabilities allow dynamic modulation of gas-liquid sorting and to separate multi-phase mixtures, with the liquid lining ensuring sustained antifouling behavior.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: June 25, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Joanna Aizenberg, Xu Hou, Mughees Khan, Alexander Tesler
  • Patent number: 10328062
    Abstract: The present invention relates to methods of therapeutic treatment of cancer using selective tyrosine kinase inhibitors and cancer biomarkers, such as MET amplification and high Met expression for patient selection.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: June 25, 2019
    Assignee: Amgen, Inc.
    Inventors: Sean Caenepeel, Angela Coxon, Zhiqiang Du, Paul Hughes, Robert Loberg, Gataree Ngarmchamnanrith, Beate Sable
  • Patent number: 10316357
    Abstract: Compositions and methods for enhanced adapter ligation are provided. The compositions and methods can be useful for next generation sequencing (NGS) library preparation and can result in higher yields in an NGS library.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: June 11, 2019
    Assignee: Swift Biosciences, Inc.
    Inventors: Vladimir Makarov, Julie Laliberte
  • Patent number: 10302573
    Abstract: One example of the present disclosure relates to an apparatus for spectroscopic analysis of residue. The apparatus includes a surface including a hydrophobic portion and a hydrophilic portion. The hydrophobic portion surrounds the hydrophilic portion. The hydrophilic portion includes a dimension equal to or larger than a width of a first incident non-destructive electromagnetic beam.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: May 28, 2019
    Assignee: The Boeing Company
    Inventor: Paul G. Vahey
  • Patent number: 10280077
    Abstract: Aspects include a method of manufacturing a flexible electronic structure that includes a metal or doped silicon substrate. Aspects include depositing an adhesive layer on the top side of the structure. Aspects also include depositing a release layer and a glass layer on the top side of the structure. Aspects also include reducing a thickness of the silicon substrate on the bottom side of the structure.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: May 7, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Paul S. Andry, Huan Hu, Katsuyuki Sakuma
  • Patent number: 10281419
    Abstract: A hydrogel-based interdigitated microelectrode biosensor is disclosed. The hydrogel-based interdigitated microelectrode biosensor includes: a first interdigitated microelectrode having a plurality of first protrusion electrodes arranged in a comb-like shape on a substrate; a second interdigitated microelectrode facing the first interdigitated microelectrode and having a plurality of second protrusion electrodes arranged in a comb-like shape on the substrate, the second protrusion electrodes being arranged alternately with the first protrusion electrodes of the first interdigitated microelectrode; and a hydrogel filled in a space between the first and second interdigitated microelectrodes arranged alternately with each other. The hydrogel is provided between the interdigitated microelectrodes such that the presence and concentration of a biological substance, such as a protein, are detected by measuring the impedance between the interdigitated microelectrodes.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: May 7, 2019
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Kyoseon Hwang, Nakwon Choi, Jinsik Kim, Hye Jin Kim, Yong Kyoung Yoo, Sang Yun Yeom, Woongsun Choi
  • Patent number: 10274504
    Abstract: Disclosed is a microcapsule encoded depending on the kind of a target substance included therein. The encoded microcapsule has a hydrophilic liquid core including the target substance and a hydrophobic shell surrounding the liquid core. The encoded microcapsule includes graphical codes introduced on the surface of the shell.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: April 30, 2019
    Assignee: QUANTAMATRIX INC.
    Inventors: Sunghoon Kwon, Younghoon Song, Taehong Kwon, Daewon Lee, Junhoi Kim
  • Patent number: 10266403
    Abstract: The invention relates to a microarray design of hybrid upconversion nanoparticles on a nanoporous anodized alumina membrane heterogeneous assay for simultaneous detection of multiple oligonucleotides, for example, oligonucleotides from different types of viruses.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: April 23, 2019
    Assignee: The Hong Kong Polytechnic University
    Inventors: Jianhua Hao, Mo Yang, Ming-Kiu Tsang, Weiwei Ye
  • Patent number: 10213140
    Abstract: The present invention described a system for an energized ophthalmic device with a media insert that includes microfluidic elements upon or within the media insert. In some embodiments, the microfluidic elements may be useful for the purpose of analyzing an analyte such as glucose in a fluid sample. In addition, some embodiments can function with a medicament administering device to treat an abnormal condition identified during the analyte analysis in the fluid sample.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: February 26, 2019
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Randall B. Pugh, Frederick A. Flitsch, Karson S. Putt
  • Patent number: 10208284
    Abstract: Provided is a device for seeding cells in a plurality of cell arrangement areas in a simple manner and a short period of time. A seeding and culturing device (1) for cells capable of forming a nerve network, the device comprising a cell-culturing substrate (2) having a plurality of cell arrangement areas (8) enclosed by a plurality of projecting parts, and a flow channel substrate (3) arranged on the cell-cultivating substrate (2) and having a plurality of through-holes (14), wherein the through-holes (14) are configured so as to provide flow channels in which the upper surface side of the substrate is an entrance (15) and the lower surface side of the substrate is an exit, and the exit (16) of the flow channels is positioned above any of the cell arrangement areas.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: February 19, 2019
    Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Tsuneo Urisu, Zhi-hong Wang, Hidetaka Uno, Yasutaka Nagaoka
  • Patent number: 10202575
    Abstract: A system (1) is provided for switching over exhaust air of a bioreactor (2) that has a disposable container (3). The system (1) has at least two exhaust air ducts (4, 5) connecting the disposable container (3) to exhaust air filters (6, 7, 18, 18?). A valve (8) is disposed in at least one of the at least two exhaust air ducts (4, 5) and enables the associated exhaust air filter (6, 7, 18, 18?) to be freed.
    Type: Grant
    Filed: March 22, 2014
    Date of Patent: February 12, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Wolfgang Kahlert, Ralf Hartmann, Bernward Husemann
  • Patent number: 10190965
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: January 29, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Priyadarshini Gogoi, Christopher Siemer, Saedeh Sepehri Javdani
  • Patent number: 10138523
    Abstract: The application discloses new biomarkers and methods useful in the diagnosis, prognosis and/or monitoring of, or as a therapeutic or research target for, solid tumor cancers, such as colorectal cancer, based on measuring the biomarkers; and related kits and devices.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: November 27, 2018
    Inventor: Jeffrey Lordan
  • Patent number: 10119965
    Abstract: The present invention relates to devices for conducting microorganism or toxin detection. More particularly, the invention relates to portable, pre-packaged devices that are suitable for culturing microorganisms, aliquoting predetermined volumes of testing samples, and conducting microorganism or toxin detection based on immunological reactions using samples of considerable size collected at remote sites away from testing laboratories.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: November 6, 2018
    Assignee: FUNDACION GAIKER
    Inventors: Jose Luis Gondra Zubieta, Paloma Aldamiz-Echebarria Zulueta, Javier Escobal Gonzalo, Miren Garbine Olabarria De Pablo, Armando Cruz Llosa, Jesus Berganza Granda, Brigitte Michele Jacqueline Sauvage
  • Patent number: 10094818
    Abstract: A method for characterising cells or cell structures in a sample comprising: obtaining at least one normalized impedance response of the sample over at least one frequency range; and characterising at least one cell using at least one characteristic of the normalized impedance response.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: October 9, 2018
    Assignee: University of Strathclyde
    Inventors: Patricia Connolly, Laurie Shedden
  • Patent number: 10087582
    Abstract: The present invention is in the field of paper production, more in particular it relates to the process of wood pulping. It provides useful biological methods and compounds for reducing the energy requirements of the production of wood pulp. It describes a method for reducing the energy requirement of a thermo-mechanical pulping (TMP) process wherein cellulose fibers are recovered from a biomass comprising lignocellulosic material, wherein the lignocellulosic material is treated with a CotA laccase before recovering the cellulose from the lignocellulosic material.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: October 2, 2018
    Assignee: METGEN OY
    Inventors: Klara Birikh, Alexey Azhayev
  • Patent number: 10088494
    Abstract: Methods and systems for reducing the run-to-run variability in measurement results obtained by a sample analysis system. The method and system utilize data from previous sample runs to optimize analysis parameters for future test runs. The methods and systems are particularly suitable for microfluidic sample analysis.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: October 2, 2018
    Assignee: PERKINELMER HEALTH SCIENCES, INC.
    Inventors: Laurel Provencher, Jingjing Wang, I-Jane Chen, David Weinberger, Wael Yared
  • Patent number: 10072050
    Abstract: The present invention relates to chromatography ligands having improved caustic stability, e.g., ligands based on immunoglobulin-binding proteins such as, Staphylococcal protein A, as well as methods of making and using such ligands.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: September 11, 2018
    Assignee: EMD Millipore Corporation
    Inventors: Nanying Bian, Neil Soice, Shari Spector, Kara Levine
  • Patent number: 10041113
    Abstract: Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: August 7, 2018
    Assignee: Applied Biosystems, LLC
    Inventors: Linda G. Lee, Sam L. Woo, Congcong Ma, Richard T. Reel, Mark F. Oldham, David M. Cox, Benjamin G. Schroeder, Jon M. Sorenson, Willy Wiyatno
  • Patent number: 10031132
    Abstract: The invention relates to a method and a device for the detection of magnetic particles (1) in a sample chamber (112). After introduction of the sample into said sample chamber (112), the magnetic particles (1) are first retained within the sample chamber (112) and kept away from the sensing surface (111) by an appropriate magnetic field (B) to allow for an incubation of the sample with reagents. A reference measurement may be made during this incubation period (TI), preferably at the end thereof. After incubation, the magnetic particles (1) are allowed to contact the sensing surface (111) where a target measurement can be conducted.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: July 24, 2018
    Assignee: Minicare B.V.
    Inventors: Sytske Foppen, Bernardus Jozef Maria Beerling, Willemina Maria Huijnen-Keur, Hendrik Jan De Graaf, Danielle Walthera Maria Kemper-Van De Wiel, Roland Antonius Johannes Gerardus Smits, Albert Hendrik Jan Immink, Femke Karina De Theije, Wendela Meertens
  • Patent number: 10024794
    Abstract: Nickel, iron and palladium thin films thermally evaporated onto glass supports are used to demonstrate surface plasmon coupled fluorescence (SPCF) and surface plasmon couple chemiluminescence (SPCC) over a broad wavelength range (400-800 nm) for potential assays or other detection systems. Nickel, iron and palladium thin films used in SPCF and SPCC convert otherwise isotropic emission into highly directional and polarized emission, an attractive concept for surface assays. The emission angles of detected emissions occur over a 10 degree range for tested emitted wavelengths.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: July 17, 2018
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventor: Chris D. Geddes
  • Patent number: 10005999
    Abstract: An apparatus and method of measuring biofilm and biological activity on a surface is disclosed. The apparatus includes a biofilm, which includes one or more microorganisms, grown on a substrate. A viewing window is placed on a surface of the biofilm and a gas bubble is introduced between the viewing window and the surface of the biofilm. The space between the substrate and the viewing window may be enclosed in a casing that has an inlet and an outlet, forming a flow cell. A microscope system, such as a white light interferometer, captures data of the biofilm in situ and non-destructively. The 3D images of biofilm surface have high resolution while maintaining a large field of view. The apparatuses and methods will be useful for fundamental studies of biofilms, biomedical and environmental screening, and many other applications in biology and the life sciences.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: June 26, 2018
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Curtis J. Larimer, Jonathan D. Suter, Raymond S. Addleman, George T. Bonheyo, Michelle R. Brann
  • Patent number: 9994909
    Abstract: The invention provides methods for identifying early stage non-small cell lung cancer (NSCLC) patients who will have a favorable prognosis for the recurrence of lung cancer after surgical resection. The invention is based on the discovery that assessment of chromosomal copy number abnormalities at two or more of chromosome 5p15, 7p12, 8q24 and centromere 6 can be used for prognostic classification. The invention preferably uses fluorescence in situ hybridization with fluorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of the these genetic loci.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: June 12, 2018
    Assignee: Abbott Molecular Inc.
    Inventors: Larry E. Morrison, John Coon
  • Patent number: 9995743
    Abstract: A test apparatus including a cassette main body, a test strip and a pressurizing assembly is provided. The cassette main body has a sample entrance. The test strip is disposed in the cassette main body, and the sample entrance of the cassette main body exposes a sample collecting region of the test strip. The pressurizing assembly is detachably combined to the cassette main body, and is adapted to exert a pressure on a liquid sample located at the sample entrance, such that the liquid sample enters the sample collecting region, and reacts with the test strip to display a test result. The test apparatus is able to implement quick and convenience test, by which a complicated pre-processing of a test sample is omitted to save a time and test cost.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: June 12, 2018
    Assignee: HTC Corporation
    Inventors: Yi-Chin Tsai, Shih-Jen Lu, Fu-Cheng Fan, Ming-Tien Lin
  • Patent number: 9989452
    Abstract: A magnetohydrodynamic microfluidic system and a method of pumping a fluid using a magnetohydrodynamic system are disclosed. The method includes applying at least one of an electric current and an electric voltage to a first modified electrode and a second electrode to generate an ionic current between the first modified electrode and the second electrode and to cause a current carrying species to move to or from the modified electrode, applying a magnetic field perpendicular to an ionic current vector, the magnetic field and the ionic current combining to induce flow of the fluid in a direction perpendicular to the magnetic field and the ionic current vector, and maintaining fluid flow by recharging the modified electrode.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: June 5, 2018
    Inventors: Ingrid Fritsch, Christena Nash, Sai Kumar, Timothy Muldoon, Kartik Balachandran, Adair Claycomb, Matthew D. Gerner, Joshua Hutcheson, Foysal Z. Khan, Amy Powless, Sandra Prieto, Preston G. Scrape, Melissa C. Weston
  • Patent number: 9972085
    Abstract: Luminance calculation means 81 calculates luminance of a cell nucleus extracted from an antinuclear antibody image of a designated dilution ratio. Titer prediction means 82 predicts an antinuclear antibody titer, using a staining pattern specified from a staining form of the cell nucleus and the luminance at at least one dilution ratio.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: May 15, 2018
    Assignee: NEC Corporation
    Inventor: Yoshiko Yoshihara
  • Patent number: 9909090
    Abstract: A cell culture kit for cultivating cells in a closed system includes at least one or more of each of: a culture container for cultivating cells; a culture medium storage container for storing a culture medium or the like; a cell injection container for injecting cells; and a cell collecting container for collecting a suspension of cells after cultivation; wherein the culture medium storage container is also used as a waste liquid container for collecting a culture medium after cultivation, and the culture container, the culture medium storage container, the cell injection container and the cell collecting container are linked to one another through a conduit.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: March 6, 2018
    Assignee: TOYO SEIKAN GROUP HOLDINGS, LTD
    Inventors: Satoshi Tanaka, Takahiko Totani, Yoichi Ishizaki
  • Patent number: 9909093
    Abstract: The present disclosure relates to a funnel apparatus for channeling cells onto a plurality of distinct, closely spaced regions of a seeding surface. The funnel apparatus has a body portion having an upper surface and a lower surface. The body portion forms a plurality of flow paths, at least one of which is shaped to have a decreasing cross-sectional area from the upper surface to the lower surface. The flow paths are formed at the lower surface to enable cells deposited into the flow paths at the upper surface of the funnel apparatus to be channeled into a plurality of distinct, closely spaced regions on the seeding surface positioned adjacent the lower surface.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: March 6, 2018
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: David Soscia, William J. Benett, Erik V. Mukerjee
  • Patent number: 9903862
    Abstract: The present invention generally relates to nanotechnology and sub-microelectronic circuitry, as well as associated methods and devices, for example, nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample. For example, a nanoscale wire device can be used in some cases to detect single base mismatches within a nucleic acid. In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between a nucleic acid or other analyte, and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: February 27, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Ying Fang, Fernando Patolsky
  • Patent number: 9867929
    Abstract: An infusion pump system is disclosed for dispensing liquid medication, such as insulin. The infusion pump system includes a first reservoir for storing liquid medication, a first fluid driver for exerting pressure on the first reservoir, a second reservoir for storing liquid medication, and a second fluid driver for exerting pressure on the second reservoir. One or more valves are used to permit flow of liquid medication from the first reservoir to the second reservoir, and to permit flow of liquid medication from the second reservoir to an infusion site. Each of the valves is selectively opened or closed to fill the second reservoir with liquid medication from the first reservoir and to dispense liquid medication from the second reservoir to the infusion site. A controller and one or more sensors are used to monitor and control the system.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: January 16, 2018
    Assignee: Becton, Dickinson and Company
    Inventors: Gary Searle, Roman Tunkel, William Tormey, III, Andrew Leonczyk, David Pollock, Paul Naumann, Kenneth Focht
  • Patent number: 9869653
    Abstract: An electrochemical sensing apparatus and methods are provided. In one embodiment, an apparatus is provided having a carrier that supports an electrochemical module and that communicates between electrodes on the electrochemical module and an analyte measurement device.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: January 16, 2018
    Assignee: LifeScan, Inc.
    Inventors: Garry Chambers, Alastair M. Hodges, Ronald C. Chatelier
  • Patent number: 9863940
    Abstract: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: January 9, 2018
    Assignee: DNAE Group Holdings Limited
    Inventors: Sergey A. Dryga, Victor C. Esch, Lisa-Jo Ann Clarizia, Eddie W. Adams, Thearith H. Ung, Ravil A. Sitdikov
  • Patent number: 9851368
    Abstract: The invention relates to a kit and methods for quantitative detection of steroids in a sample. The kit comprises quantitative charge tags and an oxidizing agent.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: December 26, 2017
    Assignee: SWANSEA UNIVERSITY
    Inventors: William Griffiths, Yuqin Wang, Peter Crick, William Bentley
  • Patent number: 9822390
    Abstract: The subject invention pertains to a microfluidic apparatus and methods for screening and isolating a target cell from a population of cells. The apparatus comprises a first microfluidic layer comprising microfluidic channels; a second microfluidic layer comprising microfluidic channels; and a microfluidic cell analysis layer comprising a top hanging blocking structure located directly below each location where the first layer microfluidic channels overlap with the second layer microfluidic channels and a cell trap juxtaposed to each of the top hanging blocking structures. The top hanging blocking structures can close or open the juxtaposed cell trap when either or both the first or second layer microfluidic channels located directly above the top hanging blocking structure are sufficiently pressurized and/or sufficiently depressurized.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: November 21, 2017
    Assignee: THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Arum Han, Hyun Soo Kim
  • Patent number: 9822002
    Abstract: Aspects include a method of manufacturing a flexible electronic structure that includes a metal or doped silicon substrate. Aspects include depositing an adhesive layer on the top side of the structure. Aspects also include depositing a release layer and a glass layer on the top side of the structure. Aspects also include reducing a thickness of the silicon substrate on the bottom side of the structure.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: November 21, 2017
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Paul S. Andry, Huan Hu, Katsuyuki Sakuma
  • Patent number: 9823204
    Abstract: Chronic obstructive pulmonary disease (COPD), characterized by chronic airflow limitation, is a serious and growing public health concern. The major environmental risk factor for COPD is cigarette smoking, but the biological mechanisms underlying COPD are not well understood. Herein, proton nuclear magnetic resonance (1H-NMR) spectroscopy is used in methods to identify metabolites and biomarkers associated with lung function in COPD.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: November 21, 2017
    Assignee: Lineagen, Inc.
    Inventors: Joseph Louie McClay, Barbara K. Zedler, Edward Lenn Murrelle, Edwin J. C. G. van den Oord, Thomas O'Connell, Daniel Adkins
  • Patent number: 9810631
    Abstract: A wavelength scanning apparatus that detects at least four different fluorescent emission wavelengths simultaneously or nearly simultaneously is described. The wavelength scanning apparatus includes a heating block having at least four sample wells, each sample well configured for receiving a sample, at least four excitation activation apertures, and at least four fluorescence emission discharge apertures. The wavelength scanning apparatus also includes an analysis scanner having at least four light sources, where the at least four light sources excite at least four fluorophores, at least four excitation light filters that filter out light except that of the desired excitation wavelength/s, at least four fluorescence emission light filters that filter out light except that of the desired fluorescent emission wavelengths, and at least four photodetectors to detect light of the desired fluorescent emission wavelengths.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: November 7, 2017
    Assignee: STEM ARTS PROJECTS, LLC
    Inventors: Abraham Oommen, Matthew Greenleaf, Adam Koch, Amitabha Sarkar
  • Patent number: 9795965
    Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: October 24, 2017
    Assignee: Brigham and Women's Hospital, Inc.
    Inventors: Joseph Italiano, Linas Mazutis, Jonathan N. Thon, David A. Weitz
  • Patent number: 9791368
    Abstract: A label-free method for the spatio-temporal mapping of protein secretions from individual cells in real time by using a chip for localized surface plasmon resonance (LSPR) imaging. The chip is a glass coverslip compatible for use in a standard microscope having at least one array of functionalized plasmonic nanostructures patterned onto it. After placing a cell on the chip, the secretions from the cell are spatially and temporally mapped using LSPR imaging. Transmitted light imaging and/or fluorescence imaging may be done simultaneously with the LSPR imaging.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 17, 2017
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers, James B. Delehanty
  • Patent number: 9752181
    Abstract: A system and method for capturing and analyzing a set of cells, comprising: an array including a set of parallel pores, each pore including a chamber including a chamber inlet and a chamber outlet, and configured to hold a single cell, and a pore channel fluidly connected to the chamber outlet; an inlet channel fluidly connected to each chamber inlet of the set of parallel pores; an outlet channel fluidly connected to each pore channel of the set of parallel pores; a set of electrophoresis channels fluidly coupled to the outlet channel, configured to receive a sieving matrix for electrophoretic separation; and a set of electrodes including a first electrode and a second electrode, wherein the set of electrodes is configured to provide an electric field that facilitates electrophoretic analysis of the set of cells.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: September 5, 2017
    Assignee: DeNovo Sciences, Inc.
    Inventors: Kalyan Handique, Priyadarshini Gogoi, Saedeh Sepehri Javdani, Yi Zhou
  • Patent number: 9746466
    Abstract: Methods, systems, devices and apparatus for use in screening and/or selecting a library of nucleic acid molecules and/or nucleic acid tagged or encoded molecules for binding to or interaction with a target molecule or substance (e.g., for use in new compound or drug discovery) are described. In some embodiments the device comprises: (a) a spatially addressable array, said array comprising a plurality of separate and discrete locations thereon; (b) a plurality of different oligomers operably connected to said spatially addressable array at different ones of said separate and discrete locations; (c) a tag sequence which is complementary to, and is hybridized to, each of said oligomers; and (d) a candidate chemical operably connected to each of said tag sequences, wherein each of said discrete locations is a unique identifier for its corresponding oligomer; and wherein said tag sequence is a unique identifier for its connected candidate chemical.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: August 29, 2017
    Assignees: NanoMedica LLC, Wake Forest University
    Inventors: Keith Bonin, Jed C. Mocosko, Jason Gagliano, Martin Guthold, Roger Cubicciotti
  • Patent number: 9746413
    Abstract: A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: August 29, 2017
    Assignee: DeNovo Sciences, Inc.
    Inventors: Kalyan Handique, Priyadarshini Gogoi, Christopher Siemer, Saedeh Sepehri Javdani
  • Patent number: 9746469
    Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: August 29, 2017
    Assignees: IDEXX Laboratories, Inc., Monsanto Company
    Inventors: David Allen Elsemore, Jinming Geng, Laurie A Flynn, Michael Crawford
  • Patent number: 9744535
    Abstract: A cassette is described which can hold at least two multiwell plates. The cassette comprising the multiwell plates can be loaded into a stacker of an automated analytical apparatus. While the stacker holds down the cassette, a lift pushes the multiwell plates upwards to make them accessible to a handler which can engage and transport the multiwell plates to a plate holder in the working area of the analytical apparatus.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: August 29, 2017
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Renato Belz, Christian Thalmann