Including Multiple Internal Compartments Or Baffles Patents (Class 435/288.2)
  • Patent number: 9909162
    Abstract: Described herein are methods and apparatus for rapid detection of microorganisms in biological samples (e.g. blood) for analysis to determine the presence or absence of infectious microorganisms in the samples. The apparatus includes a cartridge with a lid and a tray, a mechanism for isolating a bulk sample into multiple smaller samples, and a sensor disposed on the tray to determine the presence or absence of microorganisms. The cartridge lid includes projections that, in a first position, allow for sample to distribute evenly in the cartridge tray and, in a second position, isolate the sample into multiple smaller volume samples. The apparatus and method shorten the time-to-detection of a microorganism in a sample and reduce the steps required from sample collection to microorganism detection.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: March 6, 2018
    Assignee: Becton, Dickinson and Company
    Inventor: Ming-Hsiung Yeh
  • Patent number: 8999729
    Abstract: A device for conducting an agglutination assay comprising several reaction vessels, each reaction vessel comprising an upper chamber having an opening for accepting reactants and/or a sample; and a lower chamber comprising an end in communication with the upper chamber for receiving fluids from the upper chamber, a closed end opposite to the end, and a matrix for separating agglutinates from non-agglutinates; wherein the device further comprises a rotating support able to rotate around an axis and holding pivotally the reaction vessels in a way to allow the reaction vessels to pivot about an axis essentially perpendicular to the rotation axis of the support when the latter is rotated, such that the fluids remain in the upper chamber when the support is not rotated, and can flow from the upper chamber to the lower chamber and into the matrix when the support is rotated.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: April 7, 2015
    Assignee: Symbion Medical Systems Sarl
    Inventors: Isabelle Delafosse, Fabrice Ummel, Antonio Yanez
  • Patent number: 8993241
    Abstract: Provided is a device and a method whereby plural kinds of reaction operations and washing operations can be conducted in parallel without washing or replacing an instrument used in transferring a solution in each operation. A reaction device having a plurality of projecting barriers provided in a line on one surface of a substrate. The projecting barrier has a cutoff portion and an inner space capable of holding a droplet and having a contact angle to pure water of from 90 to 150 degrees. A reaction method using the reaction device wherein a substance immobilized on magnetic beads is sequentially transferred in and between droplets of a solution containing a surface tension reducing agent that are held in the spaces for holding a droplet by means of a magnet located on the opposite surface of the substrate to thereby conduct reactions and washings.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: March 31, 2015
    Assignee: National University Corporation University of Toyama
    Inventors: Masaharu Isobe, Nobuyuki Kurosawa
  • Patent number: 8969073
    Abstract: The invention describes an appliance and a method, with the help of which specific bio-particles, but also dissolved bio-molecules can be recognized in and separated from fluids making use of suitable carriers and known immobilization methods. The appliance can be used both discontinuously and also for direct and continuous treatment of fluids. Fields of application of the invention are animals, bio-technology (including biological research) and medicinal diagnostics. Areas of application of the invention comprise, among others, therapy of humans, in particular direct treatment of blood.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: March 3, 2015
    Assignee: pluriSelect GmbH
    Inventor: Hans Werner Heinrich
  • Patent number: 8945481
    Abstract: Exemplary embodiments provide microfludic devices and methods for their use. The microfluidic device can include an array of M×N reaction sites formed by intersecting a first and second plurality of fluid channels of a flow layer. The flow layer can have a matrix design and/or a blind channel design to analyze a large number of samples under a limited number of conditions. The microfluidic device can also include a control layer including a valve system for regulating solution flow through fluid channels. In addition, by aligning the control layer with the fluid channels, the detection of the microfluidic devices, e.g., optical signal collection, can be improved by piping lights to/from the reaction sites. In an exemplary embodiment, guard channels can be included in the microfluidic device for thermal cycling and/or reducing evaporation from the reaction sites.
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: February 3, 2015
    Assignee: Applied Biosystems, LLC
    Inventors: Mark F. Oldham, Kenneth J. Livak, Jason E. Babcoke, H. Pin Kao, Stephen J. Gunstream, Kevin S. Bodner, Douglas P. Greiner, Nigel P. Beard, Dar Bahatt
  • Patent number: 8940524
    Abstract: We describe a thermal cycler comprising a Peltier-type thermoelectric element used for cooling a sample block, and a non-Peltier-type heating device for heating the sample block. The cycler also includes a heat sink connected to the Peltier-type element by a heat pipe, which permits thermal energy to transfer from the Peltier-type element to the heat sink. This configuration operates more efficiently than conventional thermal cyclers which use Peltier-type elements for heating and cooling, and allows a more rapid cycling time as well as operation in a wider range of ambient temperatures. Certain embodiments utilise the Peltier-type element as a thermal gate to reduce thermal loss during heating when the Peltier-type element is switched off.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: January 27, 2015
    Assignee: Epistem Limited
    Inventor: Ben Cobb
  • Patent number: 8932544
    Abstract: Disclosed are a method and a device for feeding and/or discharging fluids in microreactor arrays through one or several fluid ducts that extend into each individual microreactor and can be individually controlled and regulated, in order to control, regulate, influence, and/or verify processes. The fed or discharged amounts of fluid are introduced into or discharged from the volume of the reaction liquid during a continuous shaking process and are evenly mixed as a result of the shaking process. The continuous shaking process causes sufficient mass transfer and thorough mixing of the reaction partners or fluids while the reaction is not limited or restricted by the mass transfer conditions.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: January 13, 2015
    Assignee: m2p-labs GmbH
    Inventors: Carsten Mueller, Ingo Klammer, Frank Kensy, Jochen Buechs, Mirko Hofmann, Andreas Buchenauer, Uwe Schnakenberg, Wilfried Mokwa
  • Patent number: 8883095
    Abstract: An analysis cartridge and an analysis system thereof are disclosed. The analysis cartridge comprises a cartridge body, a liquid storage box and a sealing film. The cartridge body has an accommodation portion. The liquid storage box is disposed within the accommodation portion and has a liquid storage tank and a pillar receiving hole. The sealing film covers the pillar receiving hole and seals an opening of the liquid storage tank.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: November 11, 2014
    Assignee: Lite-On Technology Corporation
    Inventors: Cheng-Chang Lai, Fu-Chun Huang, Yuh-Jiuan Lin, Timothy Z. Liu
  • Patent number: 8859264
    Abstract: A phantom device for in-vitro validation of radiation procedures under motion influence in consideration of an effective biological dose includes a phantom having a first biological detector with a first biological sample. The first biological sample includes a plurality of culturing and irradiation elements. Each of the culturing and irradiation elements are provided with a respective biological sub-sample so that the first biological detector is configured as a spatially resolving biological detector. A first motion device is configured to move the first biological detector so as to simulate a motion of a target volume.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: October 14, 2014
    Assignee: GSI Helmholtzzentrum fuer Schwerionenforschung GmbH
    Inventors: Christoph Bert, Eike Rietzel, Alexander Gemmel
  • Patent number: 8828654
    Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: September 9, 2014
    Assignee: Gen-Probe Incorporated
    Inventors: Norman C. Nelson, Gianluca Roma
  • Patent number: 8821814
    Abstract: A microfluidic device including a platform and a cartridge is disclosed. The platform includes a chamber containing a fluid. The reagent cartridge is mounted to the platform. and contains a solid reagent for detecting material contained in the fluid.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: September 2, 2014
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Yoonkyoung Cho, Dogyoon Kim, Beomseok Lee, Jongmyeon Park, Hyunmin Kim, Yangui Lee, Jong Gun Lee
  • Patent number: 8815178
    Abstract: The invention relates to a device and method for non-invasive detection of an analyte in a fluid sample. In one embodiment, the device comprises: a collection chamber containing an absorbent hydrogel material; a fluidic channel connected to the collection chamber; a sensing chamber connected to the fluidic channel, wherein the device is comprised of a compressible housing that allows transfer of fluid collected by the collection chamber to be transferred to be extracted and withdrawn to the sensing chamber upon compression of the device, wherein the sensing chamber contains a material that specifically detects the analyte and wherein the sensing chamber is operably linked to a processor containing a potentiostat that allows detection of the analyte using electrochemical sensing.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: August 26, 2014
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Daniel Bishop, Jeffrey La Belle
  • Patent number: 8765367
    Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: July 1, 2014
    Assignees: Gen-Probe Incorporated, Qualigen, Inc.
    Inventors: Scott S. Breidenthal, Sara H. Fan, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
  • Patent number: 8741630
    Abstract: The invention relates to methods of detecting a target analyte in a biological sample using composite microsphere arrays having first and second assay locations. Preferred target analytes include nucleic acid, and more specifically, nucleic acid having one or more single nucleotide polymorphisms (SNPs).
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: June 3, 2014
    Assignee: Illumina, Inc.
    Inventors: Todd Dickinson, Kenneth D. Coblentz, Edward Carlson
  • Patent number: 8735055
    Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: May 27, 2014
    Assignees: Gen-Probe Incorporated, Qualigen, Inc.
    Inventors: Scott S. Breidenthal, Sara H. Fan, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
  • Patent number: 8709787
    Abstract: The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are a microfluidic valve suitable for use in isolating a PCR chamber in a microfluidic substrate, and a method of making such a valve.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: April 29, 2014
    Assignee: Handylab, Inc.
    Inventor: Kalyan Handique
  • Patent number: 8685708
    Abstract: The invention provides a device for preparing a fluid sample, including but not limited to a sample comprising genomic DNA.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: April 1, 2014
    Assignee: PathoGenetix, Inc.
    Inventors: John L. Harris, Adrian Mark Thomas West, Dirk Peter Ten Broeck, Ekaterina Protozanova
  • Patent number: 8652828
    Abstract: Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: February 18, 2014
    Assignee: The Trustees of Princeton University
    Inventors: Robert H Austin, Zhaoning Yu, Jonas O Tegenfeldt, Stephen Y Chou, Han Cao
  • Patent number: 8603806
    Abstract: The methods generally relate to three-dimensional culturing of cells with the steps of seeding a cell support structure in a device with at least one vessel for cell culture having a bottom, at least one wall and a cell support structure for three-dimensional cell culture. The cell support structure is inside the at least one vessel and the device is configured such that assays can be performed. Devices for performing cell culture and assays are also provided. It will be understood that the devices can have many different suitable configurations. In general, the devices are selected such that they can be used with suitable radiation based assays.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: December 10, 2013
    Assignee: The Ohio State Universtiy Research Foundation
    Inventors: Shang-Tian Yang, Xudong Zhang, Yuan Wen
  • Patent number: 8597938
    Abstract: Provided are methods and oligonucleotides useful as primers and templates for internal controls designed for use in Real Time Reverse Transcriptase Polymerase Chain Reactions. Use of the present methods and oligonucleotides allows validation of assay parameters and of the results that an assay set.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: December 3, 2013
    Assignee: QIAGEN Sciences LLC
    Inventors: Jingping Yang, Li Shen
  • Patent number: 8585982
    Abstract: A field colorimetric test device includes a housing having at least one interior compartment. A sampling device is configured to be associated with a distal end of the housing. A selection device is attached to a proximal end of the housing.
    Type: Grant
    Filed: June 12, 2012
    Date of Patent: November 19, 2013
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Roxanne L. Quintana, Martin W. Krauss, Alvin L. Quintana
  • Patent number: 8551714
    Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: October 8, 2013
    Assignee: IntegenX Inc.
    Inventors: Stevan Bogdan Jovanovich, Iuliu Ioan Blaga
  • Patent number: 8492140
    Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: July 23, 2013
    Assignee: Octane Biotech Inc.
    Inventors: Timothy J. N. Smith, Martin R. Pecaric, Sydney J. Pugh, Rupert Hagg, Roberto Tommasini, Yves Larcher, Lowell D. Misner
  • Patent number: 8445265
    Abstract: The invention relates to a reaction vessel and a reaction controller, wherein temperature control of a liquid stored within the vessel can be performed with a high accuracy and faithful responsiveness. The reaction container and the reaction controller comprise one or a plurality of reaction chambers in which liquid is storable, and a wall that surrounds the reaction chamber, and the entirety or a part of the wall is formed by a temperature raising and lowering body that can raise or lower the temperature thereof according to a signal from an instructing part provided outside.
    Type: Grant
    Filed: October 5, 2005
    Date of Patent: May 21, 2013
    Assignee: Universal Bio Research Co., Ltd.
    Inventors: Hideji Tajima, Yoshinao Hirahara, Osamu Segawa
  • Patent number: 8425864
    Abstract: A container assembly for storing, treating, transporting and stabilizing a biological sample includes a container, a cap and a sample holder removably received in the container. The sample holder can be a platform-like device dimensioned to be supported on a ledge formed in the side wall of the container. The sample holder includes a central cavity for receiving the sample and immersing the sample in the stabilizing agent in the container. In another embodiment, the sample holder has a closure member for closing the open top end of the cavity. The container includes a liquid reagent in an amount sufficient to treat the biological sample. The biological sample is retained in a predetermined containment area of the container to maintain the biological sample immersed in the reagent without regard to the orientation of the container.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: April 23, 2013
    Assignee: Becton, Dickinson and Company
    Inventors: Bruce C. Haywood, Jamieson William Maclean Crawford, Bradley M. Wilkinson
  • Patent number: 8415140
    Abstract: An analysis device includes: a separation cavity 18 for separating a test liquid into a solution component and a solid component by using a centrifugal force; a higher specific gravity component quantitative cavity 23 for holding a portion of the separated solid component which has been transferred; a sample solution overflow cavity 22 arranged between the higher specific gravity component quantitative cavity 23 and the separation cavity 18 and connected to a connecting channel 21 for transporting the sample liquid from the separation cavity 18; and a capillary cavity 19 formed in the separation cavity 18 for temporarily holding a separated solution component (blood plasma) in the separation cavity 18. A blood plasma component 57a remaining in the separation cavity 18 is trapped by the capillary cavity 19.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: April 9, 2013
    Assignee: Panasonic Corporation
    Inventors: Hiroshi Saiki, Takashi Miki, Takuya Suzuki
  • Patent number: 8394625
    Abstract: This invention generally relates to an integrated ‘lab-on-a-Pipette’™ which will provide sample-to-answer single cell genetic diagnosis for preimplantation genetic diagnosis (PGD) and other forms of single cell analysis (SCA). SCA is a quickly growing field with substantial impact in prenatal testing, cancer biopsies, diabetes, stem cell research, and our overall understanding of heterogeneity in biology. However, single cell genetic analysis is challenging, inaccurate, and in many cases impossible, due to the small amount of sample (5 pg), and difficulties in handling small sample volumes (50-100 pL). The ‘lab-on-a-pipette’ device integrates a microaspiration tip with microfluidic analysis components to conduct in-situ, real-time single cell genetic diagnosis in a single device. The microaspiration tip extracts and encapsulate a cell into an ultra-low volume plug (˜300 pL).
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: March 12, 2013
    Inventors: Angelo Gaitas, Amar Basu
  • Patent number: 8383393
    Abstract: A titer plate and a method for detecting an analyte, and the use thereof are disclosed. According to at least one embodiment of the invention, it is proposed that a plurality of depressions and a biochip of the titer plate sposed adjacent thereto be surrounded by a wall in order to effectively prevent sample contamination when there is a high degree of spatial integration.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: February 26, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventors: Walter Gumbrecht, Peter Paulicka
  • Patent number: 8383422
    Abstract: The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: February 26, 2013
    Assignee: FUJIFILM Corporation
    Inventors: Junichi Katada, Hideyuki Karaki, Takayoshi Oyamada
  • Patent number: 8383421
    Abstract: An object of the present invention is to provide a cartridge for automatic measurement used in an automatic measuring device, capable of automatically performing measurement including heat treatment of a sample, and a measuring device using the cartridge. The present invention relates to a cartridge for use in measuring a component to be measured contained in a sample, comprising: at least a heat-treatment well for performing heat treatment of the sample; and a reaction well for reacting the component to be measured in the sample with a material specifically reacting therewith.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: February 26, 2013
    Assignee: Mitsubishi Chemical Medience Corporation
    Inventors: Atsushi Yanagida, Takashi Kurihara, Hiroyuki Yokoi, Atsushi Koyata, Yoshikazu Okamura, Daishi Miyamoto
  • Patent number: 8372343
    Abstract: Embodiments of the present invention relate to multiple coagulation test cartridges and methods of using such cartridges. In one embodiment the cartridge is a disposable single-use cartridge for use in evaluating blood clotting. The cartridge includes multiple containers, such as tubes, each of which includes one or more coagulation affecting substances. The containers can be pre-filled with substances in amounts suitable for use with a single patient's blood sample. The cartridge may include one or more containers, each of which has multiple sections, or volumes, each section storing a different coagulation affecting substance. In another embodiment the cartridge is used in a method for determining at least one appropriate coagulation affecting substance for modifying a patient's coagulation status using a multiple coagulation test system.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: February 12, 2013
    Inventor: Sheldon Goldstein
  • Patent number: 8372658
    Abstract: A chemical analytic apparatus of the present invention is the one which proposes that a miniaturization, a making low-cost and portability are possible and also the operation of each process of separation, concentration and dilution of specimen is possible, and, which includes: an introduction means (S1) that introduces a droplet to which magnetic ultrafine particles are mixed into another liquid that differs from the droplet while maintaining a single droplet; a conveyance means by which the droplet that includes the magnetic particles is conveyed in another liquid of the introduction means by applying magnetic field externally to the magnetic ultrafine particles; and processing means (S2 to S6) by which operations for processing of chemical analysis are performed one by one in the process in which the droplet to which the magnetic ultrafine particles are mixed is conveyed by the conveyance means.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: February 12, 2013
    Assignee: Japan Science and Technology Agency
    Inventors: Mitsuhiro Shikida, Kazuo Sato, Hiroyuki Honda, Kohta Inouchi
  • Patent number: 8349279
    Abstract: A samples storage system for pharmaceutical development in which the usable volumes of ultramicrotubes (384 tubes) are increased and smooth insertion and extraction of ultramicrotubes is possible irrespective of the positions of the ultramicrotubes. The samples storage system includes tubes in which samples are sealed and a storage rack for vertically accommodating a plurality of the tubes in a grid pattern. Each tube is of a rectangular hollow tubular cross-section and the intersect is tapered toward the bottom portion of the tube. Corner portions of the outer four side surfaces of the tubes are chamfered. The storage rack has engagement partition walls forming open-ended sections in a grid pattern inside the rack frame. The height of the walls is smaller than the length of the tube, and tube-supporting pins project vertically from the intersections of the grid.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: January 8, 2013
    Assignee: Tsubakimoto Chain Co.
    Inventors: Hiroyuki Taike, Kazuhiro Tsutsumi, Hisao Nishii, Nobuaki Matsumoto, Yukio Ueyama
  • Patent number: 8323953
    Abstract: A device for the detection of micro particles that can be marked by probes or antibodies capable of being detected by radiation has a filter, a supply system, and a detection system. Fluid to be examined is passed over a filter to filter out the micro particles and to perform the marking steps by supplying corresponding marking substances to the filter.
    Type: Grant
    Filed: April 29, 2008
    Date of Patent: December 4, 2012
    Assignee: EADS Deutschland GmbH
    Inventors: Alois Friedberger, Ulrich Reidt, Gerhard Müller
  • Patent number: 8318479
    Abstract: A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: November 27, 2012
    Assignees: Massachusetts Institute of Technology, Univeristy of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Karel Domansky, Linda G. Griffith, Steven R. Tannenbaum, Alan Wells, Samuel Walker Inman
  • Patent number: 8313941
    Abstract: Microfluidic devices having active features such as valves, peristaltic pumps, and mixing portions are fabricated to have a thin elastomeric membrane over the active features. The active features are activated by a tactile actuator external to the membrane, for example, a commercial Braille display. The display may be computer controlled, for example by simple text editor software, to activate individual Braille protrusions or a plurality of protrusions to actuate the active portions of the microfluidic device. Integral devices can incorporate the tactile actuators in a single device, but still external to the membrane.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: November 20, 2012
    Assignee: The Regents of The University of Michigan
    Inventors: Shuichi Takayama, Xiaoyue Zhu, Wei Gu, Gary Daniel Smith, Yunseok Heo, Brenda S. Cho, Nobuyuki Futai
  • Patent number: 8278091
    Abstract: Provided is an assay device and kit for detecting the presence or amount of an analyte of interest.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: October 2, 2012
    Assignee: Alere Switzerland GmbH
    Inventors: Paul Rutter, Chris Jones, Andrew Ledgeway, James Gani, Bryan Tissington
  • Patent number: 8273312
    Abstract: A liquid testing assembly for testing a liquid, the assembly comprising a test vessel and a stopper adapted to fit into a free end of the vessel. The stopper substantially hermetically seals the test vessel from the ambient. Further, the assembly includes a support coated with one or more identifying materials for identifying one or more constituents of the liquid. The support is fixed in the stopper and/or the vessel and extends into its interior for a predetermined distance. The liquid testing assembly when assembled is pre-evacuated to a predetermined vacuum sufficient to draw a predetermined volume of liquid to be sampled into the test vessel. The predetermined volume is of such an amount that it wets the one or more identifying materials ensuring identification of one or more constituents present in the liquid. A kit employing the liquid testing assembly is also discussed.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: September 25, 2012
    Assignee: Association for Public Health
    Inventors: Gadi Porat, Joel Stern, Boaz Rimon, Yoram Cohen
  • Patent number: 8268611
    Abstract: The invention relates to a microtiter plate and use thereof for conducting fermentation under fed-batch conditions. In order to produce a microtiter plate which permits screening under fed-batch conditions, the invention proposes that the cavities (2) of the microtiter plate according to the invention be filled with a culturing fluid and nutrient solution and be designed in such a way that each of the cavities (2) of the microtiter plate which is filled with nutrient solution is connected by a channel (4) to at least one other further cavity (3) of the microtiter plate which is filled with a culturing fluid. A diffusion barrier (13) arranged in the material permeable channel (4) controls the kinetics of the material transfer of nutrients from the cavity containing the nutrient solution to the cavities containing the culturing fluid.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: September 18, 2012
    Assignee: RWTH Aachen
    Inventor: Jochen Büchs
  • Patent number: 8263387
    Abstract: The invention relates generally to fluid processing and, in particular aspects, processing fluids for detection, selection, trapping and/or sorting of particulate moieties. Sheath flow devices described allow isolation of target species from fluid samples while avoiding non-specific binding of unwanted species to the surfaces of the separation device. Biological fluid processing, detection, sorting or selection of cells, proteins, and nucleic acids is described. The invention finds particular use in diagnostic settings, analyzing a patient's medical condition, monitoring and/or adjusting a therapeutic regimen and producing cell based products.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: September 11, 2012
    Assignee: Cynvenio Biosystems, Inc.
    Inventors: Paul Pagano, Yanting Zhang, Jiangrong Karen Qian, Hyongsok Tom Soh, Paul W. Dempsey, Andre′ De Fusco
  • Patent number: 8232084
    Abstract: A device for measuring an extracellular potential of a test cell includes a substrate having a well formed in a first surface thereof and a first trap hole formed therein. The well has a bottom. The first trap hole includes a first opening formed in the bottom of the well and extending toward a second face of the substrate, a first hollow section communicating with the first opening via a first connecting portion, and a second opening extending reaching the second surface and communicating with the first hollow section via a second connecting portion. The first connecting portion has a diameter smaller than a maximum diameter of the first hollow section, greater than a diameter of the second connecting portion, and smaller than a diameter of the test cell. The device can retain the test cell securely and accept chemicals and the test cell to be put into the device easily.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: July 31, 2012
    Assignee: Panasonic Corporation
    Inventors: Masaya Nakatani, Hiroaki Oka, Fumiaki Emoto
  • Patent number: 8216826
    Abstract: A fluid analyzing apparatus. The fluid analyzing apparatus sequentially or simultaneously detects and analyzes a multiplex fluid sample with suitable analyzing elements. Meanwhile, the fluid analyzing apparatus may be disassembled to a first unit, a second unit and a third unit, such that the analyzing elements therein are easily disposed and replaced. The fluid analyzing apparatus analyzes and detects the multiplex fluid sample by allowing the multiplex fluid sample to sequentially or simultaneously flow through a plurality of target chambers. The fluid analyzing apparatus sequentially or simultaneously transports the multiplex fluid sample to the target chambers, thereby enhancing the speed and analysis thereof.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: July 10, 2012
    Assignee: Industrial Technology Research Institute
    Inventors: Kun Feng Lee, Pei-Shin Jiang, Yuh-Jiuan Lin
  • Patent number: 8211367
    Abstract: A method of separating a cell-containing sample into a substantially cell-depleted portion, and a cell-containing portion comprising at least one of a stem cell, a lymphocyte, and a leukocyte comprises a step in which the sample is received in a vessel with at least one flexible wall. In another step, an additive and particles are added to the sample, wherein the additive substantially binds to the at least one of the stem cell, lymphocyte, and leukocyte, and the particles and wherein the particles substantially bind to the at least one of the stem cell, lymphocyte, and leukocyte, and the additive, thereby producing a cell-containing network. In a further step, the network is separated from the substantially cell-depleted portion by applying a magnetic force.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: July 3, 2012
    Inventors: James Wyatt, Matthew Scott, Vijay Mahant
  • Patent number: 8206918
    Abstract: The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: June 26, 2012
    Assignee: Northwestern University
    Inventors: David M. Kelso, Kunal Sur, Zaheer Parpia
  • Patent number: 8183033
    Abstract: The invention relates to methods for preparing and performing quantitative PCR analyses, a new sealing device and a new use. According to the invention, a sample vessel containing the samples to be analyzed is sealed by placing a planar sealing device on the vessel to cover the samples and applying pressure on the sealing device in order to deform the sealing device so as to form a light-refracting geometry individually for the samples to be analyzed. The invention offers a convenient way of sealing the vessel and forming analysis-improving optical lenses over the samples simultaneously.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: May 22, 2012
    Assignee: Bioinnovations Oy
    Inventor: Bruce R Turner
  • Patent number: 8163537
    Abstract: A nested permeable support device is described herein that can be used to perform various experiments to test new therapeutic compounds (new chemical entities). In one application, the nested permeable support device is used to perform a first pass assay to determine the bioavailability of a new chemical entity following absorption through the digestive tract and metabolism by the liver.
    Type: Grant
    Filed: April 8, 2009
    Date of Patent: April 24, 2012
    Assignee: Corning Incorporated
    Inventors: Gregory R. Martin, Allison J. Tanner
  • Patent number: 8163536
    Abstract: A device for preparing an undifferentiated cell, the device comprises means for contacting a more committed cell with an agent that causes the more committed cell to retrodifferentiate into an undifferentiated cell.
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: April 24, 2012
    Assignee: Tristem Trading (Cyprus) Limited
    Inventor: Ilham Mohamed Saleh Saeed Abuljadayel
  • Patent number: 8133721
    Abstract: A new design for a static diffusion cell for use in a diffusion sampling apparatus to be used in conjunction with automated or manual sampling is disclosed. The diffusion cell of present invention provides to an improved and efficient diffusion assay system.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: March 13, 2012
    Assignee: Alza Corporation
    Inventors: Hua Yang, Delphine Caroline Imbert
  • Patent number: 8110397
    Abstract: A reconfigurable sample preparation device includes a rotary plunger device having a hollow body and a coupling device, provided above one end of the rotary plunger, and accommodating a sample. The device also includes at least one sealed reagent module. When the rotary plunger is rotated on the coupling device, a film of the reagent module is pierced, mixing the sample with a substance from the reagent module.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: February 7, 2012
    Assignee: Smiths Detection Inc.
    Inventor: Douglas Jason Green
  • Patent number: 8110392
    Abstract: Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: February 7, 2012
    Assignee: Micronics, Inc.
    Inventors: C Frederick Battrell, John Gerdes, Stephen Mordue, Jason Capodanno, Denise Maxine Hoekstra, John R Williford, John Clemmens