Including Optical Measuring Or Testing Means Patents (Class 435/288.7)
  • Patent number: 11299727
    Abstract: A device is provided for capturing a nucleic acid in a single cell, having: a two-dimensional array comprising a substrate, a plurality of single cell capturing holes provided on one surface of the substrate, and a nucleic acid capturing region comprising, on the inside of the substrate, a nucleic acid capturing body, which is configured to capture the nucleic acids extracted from the individual cells respectively captured by the single cell capturing hole; a flow channel which is provided adjacent to the nucleic acid capturing region of the substrate, and is configured to discharge a solution in the nucleic acid capturing region; and a cylindrical structure body which is arranged on the substrate at the time of introducing a cell suspension and encloses a plurality of the single cell capturing holes, wherein the cylindrical structure body is removed after the cells are captured by the single cell capturing holes.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: April 12, 2022
    Assignee: HITACHI, LTD.
    Inventors: Tomoyuki Sakai, Masataka Shirai
  • Patent number: 11221335
    Abstract: The application provides heat-treated Limulus amebocyte lysates useful for detecting ?-glucans.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: January 11, 2022
    Assignee: Charles River Laboratories, Inc.
    Inventor: Masakazu Tsuchiya
  • Patent number: 11204279
    Abstract: An apparatus comprising a spectral filter (26) with a variable spectral filter transmission (FT(?)); an event-based imaging sensor (27) configured to produce measurement events (y1, y2, . . . , yn) which correspond to a change in a filter response (Y(t)) that is generated by an observed spectrum (X(?)), and a processor (28) configured to control the filter transmission (FT(?)) of the spectral filter (26) so that it sweeps over wavelength (?) with time (t), and to generate an estimation (X*(?)) of the observed spectrum (X(?)) based on the measurement events (y1, y2, . . . , yn) that correspond to the filter response (Y(t)) and based on the filter transmission (FT(?)).
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: December 21, 2021
    Inventors: Yalcin Incesu, Alexander Gatto
  • Patent number: 11193101
    Abstract: Methods and apparatus for detecting, quantifying, enriching, and/or separating bacterial species in fluid sample are provided. The fluid sample is provided as input to a microfluidic passage of a microfluidic device, wherein the microfluidic device comprises at least one electrode disposed adjacent to the microfluidic passage. The at least one electrode is activated to capture bacteria in the sample using dielectrophoresis, wherein the capture efficiency of bacteria is at least 99%.
    Type: Grant
    Filed: December 31, 2020
    Date of Patent: December 7, 2021
    Assignee: Fluid-Screen, Inc.
    Inventors: Monika Weber, Slawomir Antoszczyk, Robert Weber
  • Patent number: 11033901
    Abstract: Techniques regarding integrated purification-detection devices for detecting one or more biomarkers are provided. For example, one or more embodiments described herein are directed to an apparatus, comprising a housing and a microfluidic chip contained within the housing. The microfluidic chip comprises a separation unit that separates, using one or more nano deterministic lateral displacement (nanoDLD) arrays, target biological entities having a defined size range from other biological entities included in a biological fluid sample. The microfluidic chip further comprises a detection unit that facilitates detecting presence of one or more biomarkers associated with the target biological entities using one or more detection molecules or macromolecules that chemically reacts with the one or more biomarkers.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: June 15, 2021
    Inventors: Joshua T. Smith, Benjamin Wunsch, Stacey Gifford, Sung-Cheol Kim
  • Patent number: 11008540
    Abstract: A manufacturing facility for the continuous production of biopharmaceuticals integrated with single-use disposable technology.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: May 18, 2021
    Assignee: Lonza Ltd.
    Inventor: Atul Mohindra
  • Patent number: 10895564
    Abstract: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port and a cartridge for input to the cartridge receiving port. An optical detection system in the housing is capable of providing an illuminated electric field useful for Raman spectroscopy. The cartridge may have a sample well. The sample well is loaded with a mixture of water containing the analyte, Raman-scattering nanoparticles and a calibration solution. The calibration solution contains an analogue of the analyte differing in its Raman response, for example an isotope of the analyte. Optionally, a chemical compound capable of increasing interaction between the analyte and the nanoparticles may be added.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: January 19, 2021
    Assignee: ONDAVIA, INC.
    Inventors: Mark Charles Peterman, Merwan Benhabib, Carlos Atico Ariza, Samuel Louis Kleinman
  • Patent number: 10844341
    Abstract: A bioreactor outlet air conditioning system (10) has a bioreactor vessel (100) and a heat exchanger. The heat exchanger has a fluid flow path (196) from a headspace (108) in the vessel for venting air from the vessel, and a temperature control element (300) in thermal contact with the fluid flow path (196). The fluid flow path (196) may be defined by a disposable portion of the bioreactor vessel (100). A method of controlling evaporation within a bioreactor vessel (100), dependent on the required evaporation rate, adjusts the temperature of the temperature control element (300) to control the rate of evaporation of the liquid media (106) from the vessel (100), and may include monitoring fluids in the fluid flow path (196) to detect at least water content of the fluids exiting the vessel to adjust the temperature and control the rate of evaporation dependent on the detected water content levels.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: November 24, 2020
    Inventor: Adrian Neil Bargh
  • Patent number: 10801073
    Abstract: Modules, devices, systems and methods for measuring or detecting cysteine and/or methionine metabolite levels in a sample from a subject are disclosed. Various embodiments of the present invention concern modules, devices, systems and methods for prognosing or diagnosing cancer, for example, prostate, colon, ovarian or breast cancer; predicting the risk or probability of cancer recurrence; and/or for predicting, detecting and/or monitoring cystinuria or cystine stone disease.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: October 13, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Neil A. Bhowmick, Diptiman Choudhury, Michael J. Baker, Mark Sasha Drlik, Bjarne Hansen, Ayon Bhowmick
  • Patent number: 10773255
    Abstract: A cartridge and a method for testing a biological sample are provided, wherein the cartridge is filled, in an open packaging, with the sample to be tested, and wherein the packaging holds and/or supports the cartridge in a latching manner in an open state.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: September 15, 2020
    Inventor: Hannah Schmolke
  • Patent number: 10761094
    Abstract: The present invention provides self-contained systems for performing an assay for determining a chemical state, the system including a stationary cartridge for performing the assay therein, at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with said sample to report a result of the assay, wherein the at least one reagent, the sample and the at least one reporter functionality are contained within the cartridge.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: September 1, 2020
    Assignee: ACCELLIX LTD.
    Inventors: Harvey Lee Kasdan, Julien Meissonnier, Yoav Zuta, Micha Rosen, Yael Himmel, Yehoshua Broder, Bruce Davis, Bruce Goldman, Boaz Giron, Zion Botesazan, Ellezer Blasberg, Ilan Semmel, Jacques Aschkenasy
  • Patent number: 10751718
    Abstract: A biological sample reaction vessel comprising a reagent storage portion and a push rod movable relative to the reagent storage portion is provided. The reagent storage portion comprises at least one reagent containing cavity, and the reagent containing cavity is sealed by a sealing element; and the push rod is connected to the sealing element, and the push rod is used for cooperation with an external test device to separate the sealing element from the reagent storage portion. In reaction, the biological sample reaction vessel cooperates with a test cassette. By inserting the biological sample reaction vessel into the external device, the reagent in the reagent storage portion can be released rapidly.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: August 25, 2020
    Assignee: LEADWAY (HK) LIMITED
    Inventors: Shengqiang Liu, Tingfeng Gong, Huanjun He
  • Patent number: 10706559
    Abstract: Methods and apparatuses for tracking and correlating particles include an optical detector that captures a first and a second image of the particles. A video detector is used to capture a plurality of video frames of the particles. The video detector captures the video frames of the particles at a rate faster than the rate at which images are captured by the optical detector to track the movement of particles. A first image position of a particle in the first image of the particles is identified, and then the first image position of the particle is correlated to a second image position of the particle in the second image using the plurality of video frames.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: July 7, 2020
    Inventors: Adam Schilffarth, Matthew Fisher
  • Patent number: 10705019
    Abstract: An example system for inspecting a surface includes a laser, an optical system, a gated camera, and a control system. The laser is configured to emit pulses of light, with respective wavelengths of the pulses of light varying over time. The optical system includes at least one optical element, and is configured to direct light emitted by the laser to points along a scan line one point at a time. The gated camera is configured to record a fluorescent response of the surface from light having each wavelength of a plurality of wavelengths at each point along the scan line. The control system is configured to control the gated camera such that an aperture of the gated camera is open during fluorescence of the surface but closed during exposure of the surface to light emitted by the laser.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: July 7, 2020
    Assignee: The Boeing Company
    Inventors: Keith D. Humfeld, Morteza Safai
  • Patent number: 10684267
    Abstract: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port and a cartridge for input to the cartridge receiving port. An optical detection system in the housing is capable of providing an illuminated electric field useful for Raman spectroscopy. The cartridge may have a sample well. The sample well is loaded with a mixture of water containing the analyte, Raman-scattering nanoparticles and a calibration solution. The calibration solution contains an analogue of the analyte differing in its Raman response, for example an isotope of the analyte. Optionally, a chemical compound capable of increasing interaction between the analyte and the nanoparticles may be added.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: June 16, 2020
    Assignee: OndaVia, Inc.
    Inventors: Mark Charles Peterman, Merwan Benhabib, Carlos Atico Ariza, Samuel Louis Kleinman
  • Patent number: 10596540
    Abstract: Apparatus and methods for using a flow cell array are provided herein. A method includes delivering multiple items of chemical matter independently to multiple reaction sites of a flow cell array across multiple distinct instances of time; imaging multiple parallel chemical reactions at the multiple reaction sites of the flow cell array; and recording an emission from each of the multiple chemical reactions site.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: March 24, 2020
    Assignee: International Business Machines Corporation
    Inventors: Evan G. Colgan, Alexey Y. Lvov, Stanislav Polonsky
  • Patent number: 10596663
    Abstract: The present disclosure relates to a method for high precision laser processing of sapphire with submicron-order section plane using a picosecond-order pulse laser which has high transmittance wavelength to sapphire. The laser triggers ultrafine phase transformation points or electronic state removal points from a lower surface of sapphire. After elevating focal points, a trace which is parallel to laser incident direction is formed. Under a chemical corrosion environment, points of the laser trace are arranged to intersect with other another according to the cutting route to form the corresponding phase transformation region and electronic state removal region. At the same time, by utilizing the catalysis effect of microthermal effect of picosecond laser on chemical corrosion, separation of the sapphire sample along the processing path is obtained.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: March 24, 2020
    Assignee: Beijing University of Technology
    Inventors: Lingfei Ji, Tianyang Yan, Lin Li, Na An, Zhenyuan Lin, Wenhao Wang
  • Patent number: 10584367
    Abstract: A cell-spreading device may include a microchamber chip having a microchamber capable of enclosing and retaining a cell, a channel-forming frame united with the microchamber chip to form a channel on the microchamber, an inlet provided in the channel-forming frame to allow a cell suspension to flow into the channel, and an outlet provided in the channel-forming frame to allow the cell suspension, which has been allowed to flow into the channel through the inlet, to flow out from the channel. When an aperture of the microchamber is projected perpendicularly to a longitudinal width of the microchamber chip, the void ratio that is a ratio of the sum total of voids to the longitudinal width is not more than 5%, the void being a length of a portion where the projected aperture of the microchamber is not present against the longitudinal width.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: March 10, 2020
    Assignee: KONICA MINOLTA, INC.
    Inventors: Jungo Araki, Kumiko Hoshi, Shohei Yamamura, Shouki Yatsushiro, Masatoshi Kataoka
  • Patent number: 10527544
    Abstract: Disclosed are methods, systems, and apparatuses for non-invasive detection of colitis in a subject. The methods involve depositing a bodily fluid sample from the subject on an internal reflection element (IRE). A beam of infrared (IR) radiation can then be directed through the IRE under conditions such that the IR radiation interacts with the bodily fluid sample. An absorption spectrum can then be recorded over a range of preselected frequencies to detect peaks that are affected by colitis. In preferred embodiments, the methods and systems involve Fourier Transform Infrared Spectroscopy (FTIR).
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: January 7, 2020
    Inventors: Jitto Titus, Emilie Viennois, A. G. Unil Perera, Merlin Didier
  • Patent number: 10518259
    Abstract: A single-use, consumable diagnostic cartridge and method of performing a diagnostic test are provided. The cartridge has a sample inlet opening, an inlet port, a sample receiving chamber, an analysis chamber and a fluid channel extending between the sample receiving chamber and analysis chamber. A rupturable blister contains a fluid for selective mixing with a sample selectively disposed in the sample receiving chamber. A valve member, having a sample through port and a fluid passage, is selectively moveable between closed and open states. In the closed state, the fluid passage is out of fluid communication with the sample, and the sample through port is registered with the sample inlet opening and the sample receiving chamber. In the open state, the fluid passage extends between the inlet port and the sample receiving chamber to allow fluid dispelled from the blister to transport the sample to the analysis chamber.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: December 31, 2019
    Inventor: David W. Wright
  • Patent number: 10509945
    Abstract: The invention relates to a method for quantitative measurement of a biomarker by in situ immunofluorescence and uses thereof. In particular, the invention relates to a method which is a useful tool for use in the field of diagnosis, prevention and/or treatment of disease or disorders, in particular in the field of cancer management and therapy.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: December 17, 2019
    Inventors: Diego Gabriel Dupouy, Ata Tuna Ciftlik, Deborah Heintze, Martin Gijs
  • Patent number: 10508299
    Abstract: Microfluidic devices are provided for trapping, isolating, and processing single cells. The microfluidic devices include a cell capture chamber having a cell funnel positioned within the cell capture chamber to direct a cell passing through the cell capture chamber towards one or more a cell traps positioned downstream of the funnel to receive a cell flowing. The devices may further include auxiliary chambers integrated with the cell capture chamber for subsequent processing and assaying of the contents of a captured cell. Methods for cell capture and preparation are also provided that include flowing cells through a chamber, funneling the cells towards a cell trap, capturing a predefined number of the cells within the trap, interrupting the flow of cells, flowing a wash solution through the chamber to remove contaminants from the chamber, and sealing the predefined number of cells in the chamber.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: December 17, 2019
    Assignee: The University of British Columbia
    Inventors: Carl Lars Genghis Hansen, Michael Vanlnsberghe, Adam White, Oleh Petriv, Tim Leaver, Anupam Singhal, William Bowden, Veronique Lecault, Dan Da Costa, Leo Wu, Georgia Russell, Darek Sikorski
  • Patent number: 10490679
    Abstract: Provided are nanograting structures and methods of fabrication thereof that allow for stable, robust gratings and nanostructure embedded gratings that enhance electromagnetic field, fluorescence, and photothermal coupling through surface plasmon or, photonic resonance. The gratings produced exhibit long term stability of the grating structure and improved shelf life without degradation of the properties such as fluorescence enhancement. Embodiments of the invention build nanograting structures layer-by-layer to optimize structural and optical properties and to enhance durability.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: November 26, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Shubhra Gangopadhyay, Sangho Bok, Samiullah Pathan, Cherian Joseph Mathai, Sagnik Basuray, Keshab Gangopadhyay, Biyan Chen, Sheila Grant, Aaron Wood
  • Patent number: 10450541
    Abstract: A cell culture apparatus including cell culture units U and a measurement part (5). The measurement part (5) is provided with an imaging part (51) and is disposed so as to be capable of moving up and down between a back panel part (21) of a casing (2) and a culture container accommodating shelf (32). When the measurement unit (5) reaches a measurement position of each cell culture unit U which is a measurement subject, the culture container accommodating shelf (32) slides toward the measurement unit (5) so that portions to be measured of culture containers U20, U30 in each cell culture unit U come in an imaging range of the imaging part (51).
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: October 22, 2019
    Inventors: Osamu Koseki, Ryo Suenaga, Ken Kashiwabara
  • Patent number: 10427152
    Abstract: A diagnostic cartridge and method of performing a diagnostic test are provided. The cartridge includes a body having a sample chamber for receipt of a sample, an analysis chamber, and a reagent-containing dispensing member. A valve member is coupled to the body for selective movement between first and second states. The valve member has a fluid passage with a hydroscopic, gas permeable vent. In the first state, the fluid passage is out of fluid communication with the sample chamber and is registered for fluid communication with the reagent-containing dispensing member. The vent prevents fluid from passing therethrough and allows air to vent therefrom as reagent flows into and fills the fluid passage. In the second state, the fluid passage remains in fluid communication with the reagent-containing dispensing member and is brought into fluid communication with the sample chamber to facilitate transporting the sample to the analysis chamber.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: October 1, 2019
    Assignee: WI, INC.
    Inventors: David W. Wright, Peter W. Kroehl, Paul S. Wright
  • Patent number: 10333018
    Abstract: A cytometer includes an avalanche photodiode, a switching power supply, a filter, and voltage adjustment circuitry. The switching power supply includes a feedback loop. The filter is electrically connected between the switching power supply and the avalanche photodiode. The voltage adjustment circuitry adjusts a voltage on the feedback loop based at least in part on a voltage measured between the filter and the avalanche photodiode.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: June 25, 2019
    Assignee: Premium Genetics (UK) LTD
    Inventors: Frederick Hershel Savage, Glenn J. Szejna, Zheng Xia
  • Patent number: 10272431
    Abstract: Described here is a microfabricated particle sorting device that uses a transient pulse of fluidic pressure to deflect the target particle. The transient pulse may be generated by a microfabricated (MEMS) actuator, which pushes a volume of fluid into a channel, or sucks a volume of fluid from the channel. The transient pressure pulse may divert a target particle into a sort channel.
    Type: Grant
    Filed: February 18, 2017
    Date of Patent: April 30, 2019
    Assignee: Owl biomedical, Inc.
    Inventors: John S Foster, Stefan Miltenyi, Kevin Shields, Mehran Hoonejani
  • Patent number: 10247740
    Abstract: A detector arrangement is disclosed for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating the colorimetric sensor, a control circuit for selectively and alternately activating the sensor LED and the reference LED, and a photodetector. The photodetector measures reflectance from the colorimetric sensor during the selective and alternating illumination of the colorimetric sensor with the sensor LED and the reference LED and generates intensity signals. The reference LED is selected to have a peak wavelength of illumination such that the intensity signals of the photodetector from illumination by the reference LED are not substantially affected by changes in the color of the colorimetric sensor.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: April 2, 2019
    Assignee: bioMerieux, Inc.
    Inventor: Bradford G. Clay
  • Patent number: 10184930
    Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: January 22, 2019
    Assignee: STC.UNM
    Inventors: Steven R. J. Brueck, Jeremy Scott Edwards, Alexander Neumann, Yuliya Kuznetsova, Edgar A. Mendoza
  • Patent number: 10139219
    Abstract: An optical distance measuring apparatus includes: a scanning element scanning a coherent irradiation light from a light source and sending it to an object under measurement; a photo detector receiving the irradiation light modulated by being passed through the object under measurement in accordance with the scanning, and performing photoelectric conversion on the irradiation light; and a measuring unit obtaining phase information of the object under measurement based on a signal photoelectrically converted by the photo detector and a signal to be a reference for the scanning by the scanning element, and obtaining a measurement value regarding the object under measurement based on the phase information.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: November 27, 2018
    Assignee: ASTRODESIGN, INC.
    Inventors: Toshiharu Takesue, Shigeto Takeda, Nobuyuki Nishizawa, Tatsuho Arima, Shigeaki Suzuki
  • Patent number: 10047335
    Abstract: A cell picking support device, a display device and a culture container that can enhance work efficiency. An adapter fixes a well plate that holds cells cultured in a cell culture observation device. A control unit reads culture observation information that includes cell information and coordinate information, from a memory card that is fitted to an external memory I/F. A display unit is provided on a placing surface side of the well plate that is fixed by the adapter, and in response to control by the control unit, displays the cell information, read from the memory card, at display positions corresponding to positions on the bottom face of the well plate, as specified by the coordinate information. Embodiments can be used, for instance, as a cell picking support device that supports a picking operation that is performed in a clean bench.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: August 14, 2018
    Inventor: Yasujiro Kiyota
  • Patent number: 9964490
    Abstract: The present invention relates to devices and methods for measuring the quantity of multiple analytes in a sample. The device is designed such that each of the analyte sensing elements is configured to measure the quantity of a predetermined analyte and where the machine executable instructions are configured to select the proper analyte sensing element corresponding to the analyte to be measured.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: May 8, 2018
    Assignee: Life Technologies Corporation
    Inventors: Matthew Beaudet, Jill Hendrickson, David Hagen, Rich Meyer
  • Patent number: 9885661
    Abstract: Disclosed is an analyte detection method for detecting an analyte contained in a biological sample, constituted by irradiating a light of a first peak wavelength on a complex containing an analyte and fluorescent substance which gives off light of a second peak wavelength of 450 nm or higher but not exceeding 900 nm when irradiated with light of the first wavelength of 190 nm or higher but not exceeding 350 nm, detecting the light of the second peak wavelength given off by the fluorescent substance when irradiated by light of the first peak wavelength, by a photodetector, wherein the photodetector has a quantum efficiency in the second peak wavelength that is two or more times the quantum efficiency in the first peak wavelength.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: February 6, 2018
    Inventors: Ayato Tagawa, Hiroya Kirimura
  • Patent number: 9827718
    Abstract: A 3D printing device is provided. The 3D printing device is adapted to print a 3D object including a plurality of layer objects. The 3D printing device includes a weight sensor, which is configured to measure an actual weight value of the layer objects formed on a carrying surface or configured to measure an actual weight value of a feed tray. A controller of the 3D printing device estimates an ideal weight value corresponding to a first layer object according to a printing sequence of the first layer object in the layer objects. The controller receives the actual weight value corresponding to the first layer object from the weight sensor, and compares the ideal weight value with the actual weight value to determine whether printing abnormity is occurred. According to the disclosure, the printing quality of the 3D printing device is improved.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: November 28, 2017
    Assignees: XYZprinting, Inc., Kinpo Electronics, Inc., Cal-Comp Electronics & Communications Company Limted
    Inventor: Shou-Chih Sun
  • Patent number: 9808806
    Abstract: An embodiment of a device for automatically executing a process of generating an emulsion containing nucleic acids, amplifying the nucleic acids in the emulsion, breaking the emulsion, and separating and purifying said amplified nucleic acids, is described that comprises an emulsion generation unit for sealing beads to which nucleic acids are bound in a water-in-oil type emulsion; a nucleic acid amplification unit provided with a reaction vessel for amplifying said nucleic acids and a heating and cooling part for heating and cooling the reaction vessel; an emulsion breaking unit for breaking the emulsion after nucleic acid amplification; and a nucleic acid purification unit for recovering said amplified nucleic acids from said emulsion breaking unit.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: November 7, 2017
    Assignee: 454 Life Sciences Corporation
    Inventors: Hideji Tajima, Tetsuya Ueda, Shuichi Kobayashi, Nathan Robert Kane
  • Patent number: 9708198
    Abstract: According to one embodiment, a container for removing antimicrobials from an antimicrobial composition includes a container body having an exterior and an interior. The interior is at least partially filled with carbon granules configured to remove a portion of the antimicrobials in the antimicrobial composition. The interior is further filled with a liquid to at least a level that completely submerges each of the carbon granules. The container further includes an agitator configured to agitate at least a portion of the carbon granules. The container further includes a drain and a drainage valve. The location of the drainage valve is configured to prevent the drainage valve from lowering a current level of the liquid below the level that completely submerges each of the carbon granules.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: July 18, 2017
    Inventors: Justin Massey, Tim Yeaman
  • Patent number: 9657262
    Abstract: An apparatus for treating a biomass feedstock at a high temperature, includes a cooling device 90 for cooling a biomass treated liquid at a high temperature; an enzymatic saccharification tank 103 for saccharifying a cooled treated liquid 101B with an enzyme; a solid-liquid separation apparatus 112 for removing water-slightly soluble substances contained in a saccharide solution 104 taken out from the enzymatic saccharification tank 103 and a foreign substance removing unit 113 provided with a microfiltration (MF) membrane 113a; a dilution tank 132, disposed downstream of the foreign substance removing unit 113, for diluting the saccharide solution from which the water-slightly soluble substances are removed by adding water thereto; a water separation unit 116, provided with a reverse osmosis (RO) membrane 116a, for removing water 114 from the diluted saccharide solution so as to obtain concentrated saccharide solution 115.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: May 23, 2017
    Inventors: Akira Nishimura, Takahiro Yamauchi, Kentaro Ogura, Haruka Nishimoto, Hiroyuki Kurihara, Atsushi Minamino, Hideo Suzuki, Gaku Kondo
  • Patent number: 9644229
    Abstract: A microorganism evaluation system for analyzing microorganisms within a fluid flow, comprising a microorganism stimulation section comprising a means for inducing a motive response in a living microorganism within the fluid flow passing through the microorganism stimulation section, and a viewing section in fluid communication with the microorganism stimulation section, the viewing section comprising a body having formed therein a body cavity defining a viewing port visible through a cavity first opening formed in the body so as to be in communication with the body cavity, the viewing section further comprising an optical system mounted relative to the body for viewing the fluid flow within the viewing port through the cavity first opening, whereby image data relating to the fluid flow and microorganisms therein is acquired via the optical system for analysis.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: May 9, 2017
    Inventor: John Miles Brubacher
  • Patent number: 9623415
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: April 18, 2017
    Assignee: Click Diagnostics, Inc.
    Inventors: Boris Andreyev, Keith E. Moravick, Brian Ciopyk, Victor Briones, Gregory Loney, Adam de la Zerda, Jesus Ching, Colin Kelly, Steven Chu, David Swenson, Helen Huang
  • Patent number: 9592001
    Abstract: An implantable nanosensor includes a stent to be implanted inside a fluid conduit. The stent has a well in a surface of the stent. The implantable nanosensor further includes a nanoscale-patterned sensing substrate disposed in the well. The nanoscale-patterned sensing substrate is to produce an optical scattering response signal indicative of a presence of an analyte in a fluid carried by the fluid conduit when interrogated by an optical stimulus signal.
    Type: Grant
    Filed: July 29, 2012
    Date of Patent: March 14, 2017
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Steven Barcelo, Zhiyong Li, Ansoon Kim, Gary Gibson
  • Patent number: 9556469
    Abstract: Porous sol-gel material essentially consisting of units of one or more first polyalkoxysilanes chosen from the following compounds: (chloromethyl)triethoxysilane; 1,3-dimethyltetramethoxydisiloxane; ethyltrimethoxysilane; triethoxy(ethyl)silane; triethoxymethylsilane; triethoxy(vinyl)silane; trimethoxymethylsilane; trimethoxy(vinyl)silane; tetraethoxysilane or tetramethoxysilane (TMOS) and of units of one or more second polyalkoxysilanes chosen from the following compounds: (N-(3-(trimethoxysilyl)propyl)ethylenediamine; 3-aminopropyltriethoxysilane (APTES) and 3-aminopropyltrimethoxysilane, in a first polyalkoxysilane/second polyalkoxysilane molar ratio of 1/0.01 to 1/1, optionally comprising a probe molecule, method of preparation and applications in the trapping of monocyclic aromatic hydrocarbons and other pollutants or in their detection.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: January 31, 2017
    Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre National de la Recherche Scientifique
    Inventors: Pierre Marcoux, Mathieu Dupoy, Laure-Hélène Guillemot, Thu-Hoa Tran-Thi
  • Patent number: 9494465
    Abstract: A Raman spectroscopic apparatus analyzes a substance under analysis and includes a light source that emits light of a first wavelength, an optical device that adsorbs the substance under analysis and is irradiated with the light of the first wavelength, and an optical detector that receives light radiated from the optical device. The optical device includes a first structural member that generates charge transfer resonance in response to the light of the first wavelength and a second structural member that is less than or equal to 5 nm from the first structural member and generates surface plasmon resonance in response to the light of the first wavelength. The first structural member is made of a metal or a semiconductor, and the second structural member is made of a metal different from the material of the first structural member.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: November 15, 2016
    Assignee: Seiko Epson Corporation
    Inventor: Kohei Yamada
  • Patent number: 9428287
    Abstract: Methods of fabricating a culture container include molding a single monolithic layer of polymeric material into a container body having a container shape; introducing a colorimetric sensor material and growth media into the container body; introducing a gas mixture into the container body to define a headspace gas in an upper portion of the container body; attaching a stopper to the neck of the container body with the sensor material; sealing the container body with the stopper closed to define a sealed container with the growth media and the headspace gas enclosed therein; then sterilizing the sealed container; then applying a gas barrier coating to an exterior of the sterilized container body so that the sealed container has an oxygen transmission rate (cubic centimeter/container/day/atm) that is between about 0.001 to about 0.01 to thereby define a culture container that is ready-to-use and shelf stable without autoclaving.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: August 30, 2016
    Assignee: bioMérieux, Inc.
    Inventors: Weihua Sonya Wolters, Stanley Michael Philipak
  • Patent number: 9421543
    Abstract: A hydrodynamic filter unit includes an inlet channel connected to a fluid chamber, into which a fluid including a target material is introduced, and a plurality of outlet channels connected to the fluid chamber, through which the fluid is discharged. A filtering method includes introducing a fluid including a target material into the hydrodynamic filter unit through the inlet channel, capturing the target material in the hydrodynamic filter unit, and discharging a remaining part of the fluid outside of the hydrodynamic filter unit through an outlet channel.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: August 23, 2016
    Inventors: Minseok S. Kim, Won-ho Lee, Sun-soo Kim, Jin-hoon Kim, Jeong-gun Lee, Tae-seok Sim
  • Patent number: 9395594
    Abstract: Provided is an electrochromic element having: a pair of electrodes; an electrochromic layer which is provided between the pair of electrodes and has an electrolyte and an electrochromic material; and a spacer which surrounds a periphery of the electrochromic layer, the element having a change mechanism that changes a thickness of the electrochromic layer.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: July 19, 2016
    Assignee: Canon Kabushiki Kaisha
    Inventors: Jun Yamamoto, Kazuya Miyazaki
  • Patent number: 9346197
    Abstract: A microfluidic device having a substrate with an array of curvilinear cavities. The substrate of the microfluidic device is preferably fabricated of a polymer such as polydimethylsiloxane (PDMS). The microfluidic device is manufactured using a gas expansion molding (GEM) technique.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: May 24, 2016
    Assignee: University of Rochester
    Inventor: Lisa A. DeLouise
  • Patent number: 9244069
    Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: January 26, 2016
    Assignee: Dynex Technologies
    Inventors: Adrian Bunce, Andrew Fusellier
  • Patent number: 9217703
    Abstract: A photoacoustic flow cytometry (PAFC) device for the in vivo detection of cells circulating in blood or lymphatic vessels is described. Ultrasound transducers attached to the skin of an organism detect the photoacoustic ultrasound waves emitted by target objects in response to their illumination by at least one pulse of laser energy delivered using at least one wavelength. The wavelengths of the laser light pulse may be varied to optimize the absorption of the laser energy by the target object. Target objects detected by the device may be unlabelled biological cells or cell products, contrast agents, or biological cells labeled with one or more contrast agents.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: December 22, 2015
    Inventor: Vladimir Pavlovich Zharov
  • Patent number: 9186670
    Abstract: A microfluidic device and method is provided for handheld diagnostics and assays. The device includes a base having outer surface and a channel therethough for receiving fluid therein. The channel has input and output ports communicating with the outer surface. A lid is also provided. The lid has an outer surface, a first well having a port communicating with the outer surface of the lid, and a second well having a port communicating with the outer surface. The lid moveable between a first disengaged position and a second engaged position wherein the first port of the lid is adjacent the input port of the channel and the second port is adjacent the output port of the channel.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: November 17, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Erwin Berthier, Eric Sackmann, Peter Cavnar, David Beebe, David John Guckenberger
  • Patent number: 9151742
    Abstract: Disclosed herein are hand-held medical devices, such as blood glucose meters, that include a housing with a cassette compartment for receiving an exchangeable test tape cassette, a drive assembly comprising an electric motor and a gear arrangement adapted for rotating a tape spool of the test tape cassette, where the gear arrangement has a worm drive in which a worm meshes with a worm wheel and a multistage speed-reducing unit comprising a plurality of spur gears arranged between the worm wheel and an output gear that can be directly coupled to the tape spool.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: October 6, 2015
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Ming-Wen Chen