Including Optical Measuring Or Testing Means Patents (Class 435/288.7)
  • Patent number: 10427152
    Abstract: A diagnostic cartridge and method of performing a diagnostic test are provided. The cartridge includes a body having a sample chamber for receipt of a sample, an analysis chamber, and a reagent-containing dispensing member. A valve member is coupled to the body for selective movement between first and second states. The valve member has a fluid passage with a hydroscopic, gas permeable vent. In the first state, the fluid passage is out of fluid communication with the sample chamber and is registered for fluid communication with the reagent-containing dispensing member. The vent prevents fluid from passing therethrough and allows air to vent therefrom as reagent flows into and fills the fluid passage. In the second state, the fluid passage remains in fluid communication with the reagent-containing dispensing member and is brought into fluid communication with the sample chamber to facilitate transporting the sample to the analysis chamber.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: October 1, 2019
    Assignee: WI, INC.
    Inventors: David W. Wright, Peter W. Kroehl, Paul S. Wright
  • Patent number: 10333018
    Abstract: A cytometer includes an avalanche photodiode, a switching power supply, a filter, and voltage adjustment circuitry. The switching power supply includes a feedback loop. The filter is electrically connected between the switching power supply and the avalanche photodiode. The voltage adjustment circuitry adjusts a voltage on the feedback loop based at least in part on a voltage measured between the filter and the avalanche photodiode.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: June 25, 2019
    Assignee: Premium Genetics (UK) LTD
    Inventors: Frederick Hershel Savage, Glenn J. Szejna, Zheng Xia
  • Patent number: 10272431
    Abstract: Described here is a microfabricated particle sorting device that uses a transient pulse of fluidic pressure to deflect the target particle. The transient pulse may be generated by a microfabricated (MEMS) actuator, which pushes a volume of fluid into a channel, or sucks a volume of fluid from the channel. The transient pressure pulse may divert a target particle into a sort channel.
    Type: Grant
    Filed: February 18, 2017
    Date of Patent: April 30, 2019
    Assignee: Owl biomedical, Inc.
    Inventors: John S Foster, Stefan Miltenyi, Kevin Shields, Mehran Hoonejani
  • Patent number: 10247740
    Abstract: A detector arrangement is disclosed for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating the colorimetric sensor, a control circuit for selectively and alternately activating the sensor LED and the reference LED, and a photodetector. The photodetector measures reflectance from the colorimetric sensor during the selective and alternating illumination of the colorimetric sensor with the sensor LED and the reference LED and generates intensity signals. The reference LED is selected to have a peak wavelength of illumination such that the intensity signals of the photodetector from illumination by the reference LED are not substantially affected by changes in the color of the colorimetric sensor.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: April 2, 2019
    Assignee: bioMerieux, Inc.
    Inventor: Bradford G. Clay
  • Patent number: 10184930
    Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: January 22, 2019
    Assignee: STC.UNM
    Inventors: Steven R. J. Brueck, Jeremy Scott Edwards, Alexander Neumann, Yuliya Kuznetsova, Edgar A. Mendoza
  • Patent number: 10139219
    Abstract: An optical distance measuring apparatus includes: a scanning element scanning a coherent irradiation light from a light source and sending it to an object under measurement; a photo detector receiving the irradiation light modulated by being passed through the object under measurement in accordance with the scanning, and performing photoelectric conversion on the irradiation light; and a measuring unit obtaining phase information of the object under measurement based on a signal photoelectrically converted by the photo detector and a signal to be a reference for the scanning by the scanning element, and obtaining a measurement value regarding the object under measurement based on the phase information.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: November 27, 2018
    Assignee: ASTRODESIGN, INC.
    Inventors: Toshiharu Takesue, Shigeto Takeda, Nobuyuki Nishizawa, Tatsuho Arima, Shigeaki Suzuki
  • Patent number: 10047335
    Abstract: A cell picking support device, a display device and a culture container that can enhance work efficiency. An adapter fixes a well plate that holds cells cultured in a cell culture observation device. A control unit reads culture observation information that includes cell information and coordinate information, from a memory card that is fitted to an external memory I/F. A display unit is provided on a placing surface side of the well plate that is fixed by the adapter, and in response to control by the control unit, displays the cell information, read from the memory card, at display positions corresponding to positions on the bottom face of the well plate, as specified by the coordinate information. Embodiments can be used, for instance, as a cell picking support device that supports a picking operation that is performed in a clean bench.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: August 14, 2018
    Inventor: Yasujiro Kiyota
  • Patent number: 9964490
    Abstract: The present invention relates to devices and methods for measuring the quantity of multiple analytes in a sample. The device is designed such that each of the analyte sensing elements is configured to measure the quantity of a predetermined analyte and where the machine executable instructions are configured to select the proper analyte sensing element corresponding to the analyte to be measured.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: May 8, 2018
    Assignee: Life Technologies Corporation
    Inventors: Matthew Beaudet, Jill Hendrickson, David Hagen, Rich Meyer
  • Patent number: 9885661
    Abstract: Disclosed is an analyte detection method for detecting an analyte contained in a biological sample, constituted by irradiating a light of a first peak wavelength on a complex containing an analyte and fluorescent substance which gives off light of a second peak wavelength of 450 nm or higher but not exceeding 900 nm when irradiated with light of the first wavelength of 190 nm or higher but not exceeding 350 nm, detecting the light of the second peak wavelength given off by the fluorescent substance when irradiated by light of the first peak wavelength, by a photodetector, wherein the photodetector has a quantum efficiency in the second peak wavelength that is two or more times the quantum efficiency in the first peak wavelength.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: February 6, 2018
    Inventors: Ayato Tagawa, Hiroya Kirimura
  • Patent number: 9827718
    Abstract: A 3D printing device is provided. The 3D printing device is adapted to print a 3D object including a plurality of layer objects. The 3D printing device includes a weight sensor, which is configured to measure an actual weight value of the layer objects formed on a carrying surface or configured to measure an actual weight value of a feed tray. A controller of the 3D printing device estimates an ideal weight value corresponding to a first layer object according to a printing sequence of the first layer object in the layer objects. The controller receives the actual weight value corresponding to the first layer object from the weight sensor, and compares the ideal weight value with the actual weight value to determine whether printing abnormity is occurred. According to the disclosure, the printing quality of the 3D printing device is improved.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: November 28, 2017
    Assignees: XYZprinting, Inc., Kinpo Electronics, Inc., Cal-Comp Electronics & Communications Company Limted
    Inventor: Shou-Chih Sun
  • Patent number: 9808806
    Abstract: An embodiment of a device for automatically executing a process of generating an emulsion containing nucleic acids, amplifying the nucleic acids in the emulsion, breaking the emulsion, and separating and purifying said amplified nucleic acids, is described that comprises an emulsion generation unit for sealing beads to which nucleic acids are bound in a water-in-oil type emulsion; a nucleic acid amplification unit provided with a reaction vessel for amplifying said nucleic acids and a heating and cooling part for heating and cooling the reaction vessel; an emulsion breaking unit for breaking the emulsion after nucleic acid amplification; and a nucleic acid purification unit for recovering said amplified nucleic acids from said emulsion breaking unit.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: November 7, 2017
    Assignee: 454 Life Sciences Corporation
    Inventors: Hideji Tajima, Tetsuya Ueda, Shuichi Kobayashi, Nathan Robert Kane
  • Patent number: 9708198
    Abstract: According to one embodiment, a container for removing antimicrobials from an antimicrobial composition includes a container body having an exterior and an interior. The interior is at least partially filled with carbon granules configured to remove a portion of the antimicrobials in the antimicrobial composition. The interior is further filled with a liquid to at least a level that completely submerges each of the carbon granules. The container further includes an agitator configured to agitate at least a portion of the carbon granules. The container further includes a drain and a drainage valve. The location of the drainage valve is configured to prevent the drainage valve from lowering a current level of the liquid below the level that completely submerges each of the carbon granules.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: July 18, 2017
    Inventors: Justin Massey, Tim Yeaman
  • Patent number: 9657262
    Abstract: An apparatus for treating a biomass feedstock at a high temperature, includes a cooling device 90 for cooling a biomass treated liquid at a high temperature; an enzymatic saccharification tank 103 for saccharifying a cooled treated liquid 101B with an enzyme; a solid-liquid separation apparatus 112 for removing water-slightly soluble substances contained in a saccharide solution 104 taken out from the enzymatic saccharification tank 103 and a foreign substance removing unit 113 provided with a microfiltration (MF) membrane 113a; a dilution tank 132, disposed downstream of the foreign substance removing unit 113, for diluting the saccharide solution from which the water-slightly soluble substances are removed by adding water thereto; a water separation unit 116, provided with a reverse osmosis (RO) membrane 116a, for removing water 114 from the diluted saccharide solution so as to obtain concentrated saccharide solution 115.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: May 23, 2017
    Inventors: Akira Nishimura, Takahiro Yamauchi, Kentaro Ogura, Haruka Nishimoto, Hiroyuki Kurihara, Atsushi Minamino, Hideo Suzuki, Gaku Kondo
  • Patent number: 9644229
    Abstract: A microorganism evaluation system for analyzing microorganisms within a fluid flow, comprising a microorganism stimulation section comprising a means for inducing a motive response in a living microorganism within the fluid flow passing through the microorganism stimulation section, and a viewing section in fluid communication with the microorganism stimulation section, the viewing section comprising a body having formed therein a body cavity defining a viewing port visible through a cavity first opening formed in the body so as to be in communication with the body cavity, the viewing section further comprising an optical system mounted relative to the body for viewing the fluid flow within the viewing port through the cavity first opening, whereby image data relating to the fluid flow and microorganisms therein is acquired via the optical system for analysis.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: May 9, 2017
    Inventor: John Miles Brubacher
  • Patent number: 9623415
    Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: April 18, 2017
    Assignee: Click Diagnostics, Inc.
    Inventors: Boris Andreyev, Keith E. Moravick, Brian Ciopyk, Victor Briones, Gregory Loney, Adam de la Zerda, Jesus Ching, Colin Kelly, Steven Chu, David Swenson, Helen Huang
  • Patent number: 9592001
    Abstract: An implantable nanosensor includes a stent to be implanted inside a fluid conduit. The stent has a well in a surface of the stent. The implantable nanosensor further includes a nanoscale-patterned sensing substrate disposed in the well. The nanoscale-patterned sensing substrate is to produce an optical scattering response signal indicative of a presence of an analyte in a fluid carried by the fluid conduit when interrogated by an optical stimulus signal.
    Type: Grant
    Filed: July 29, 2012
    Date of Patent: March 14, 2017
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Steven Barcelo, Zhiyong Li, Ansoon Kim, Gary Gibson
  • Patent number: 9556469
    Abstract: Porous sol-gel material essentially consisting of units of one or more first polyalkoxysilanes chosen from the following compounds: (chloromethyl)triethoxysilane; 1,3-dimethyltetramethoxydisiloxane; ethyltrimethoxysilane; triethoxy(ethyl)silane; triethoxymethylsilane; triethoxy(vinyl)silane; trimethoxymethylsilane; trimethoxy(vinyl)silane; tetraethoxysilane or tetramethoxysilane (TMOS) and of units of one or more second polyalkoxysilanes chosen from the following compounds: (N-(3-(trimethoxysilyl)propyl)ethylenediamine; 3-aminopropyltriethoxysilane (APTES) and 3-aminopropyltrimethoxysilane, in a first polyalkoxysilane/second polyalkoxysilane molar ratio of 1/0.01 to 1/1, optionally comprising a probe molecule, method of preparation and applications in the trapping of monocyclic aromatic hydrocarbons and other pollutants or in their detection.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: January 31, 2017
    Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre National de la Recherche Scientifique
    Inventors: Pierre Marcoux, Mathieu Dupoy, Laure-Hélène Guillemot, Thu-Hoa Tran-Thi
  • Patent number: 9494465
    Abstract: A Raman spectroscopic apparatus analyzes a substance under analysis and includes a light source that emits light of a first wavelength, an optical device that adsorbs the substance under analysis and is irradiated with the light of the first wavelength, and an optical detector that receives light radiated from the optical device. The optical device includes a first structural member that generates charge transfer resonance in response to the light of the first wavelength and a second structural member that is less than or equal to 5 nm from the first structural member and generates surface plasmon resonance in response to the light of the first wavelength. The first structural member is made of a metal or a semiconductor, and the second structural member is made of a metal different from the material of the first structural member.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: November 15, 2016
    Assignee: Seiko Epson Corporation
    Inventor: Kohei Yamada
  • Patent number: 9428287
    Abstract: Methods of fabricating a culture container include molding a single monolithic layer of polymeric material into a container body having a container shape; introducing a colorimetric sensor material and growth media into the container body; introducing a gas mixture into the container body to define a headspace gas in an upper portion of the container body; attaching a stopper to the neck of the container body with the sensor material; sealing the container body with the stopper closed to define a sealed container with the growth media and the headspace gas enclosed therein; then sterilizing the sealed container; then applying a gas barrier coating to an exterior of the sterilized container body so that the sealed container has an oxygen transmission rate (cubic centimeter/container/day/atm) that is between about 0.001 to about 0.01 to thereby define a culture container that is ready-to-use and shelf stable without autoclaving.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: August 30, 2016
    Assignee: bioMérieux, Inc.
    Inventors: Weihua Sonya Wolters, Stanley Michael Philipak
  • Patent number: 9421543
    Abstract: A hydrodynamic filter unit includes an inlet channel connected to a fluid chamber, into which a fluid including a target material is introduced, and a plurality of outlet channels connected to the fluid chamber, through which the fluid is discharged. A filtering method includes introducing a fluid including a target material into the hydrodynamic filter unit through the inlet channel, capturing the target material in the hydrodynamic filter unit, and discharging a remaining part of the fluid outside of the hydrodynamic filter unit through an outlet channel.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: August 23, 2016
    Inventors: Minseok S. Kim, Won-ho Lee, Sun-soo Kim, Jin-hoon Kim, Jeong-gun Lee, Tae-seok Sim
  • Patent number: 9395594
    Abstract: Provided is an electrochromic element having: a pair of electrodes; an electrochromic layer which is provided between the pair of electrodes and has an electrolyte and an electrochromic material; and a spacer which surrounds a periphery of the electrochromic layer, the element having a change mechanism that changes a thickness of the electrochromic layer.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: July 19, 2016
    Assignee: Canon Kabushiki Kaisha
    Inventors: Jun Yamamoto, Kazuya Miyazaki
  • Patent number: 9346197
    Abstract: A microfluidic device having a substrate with an array of curvilinear cavities. The substrate of the microfluidic device is preferably fabricated of a polymer such as polydimethylsiloxane (PDMS). The microfluidic device is manufactured using a gas expansion molding (GEM) technique.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: May 24, 2016
    Assignee: University of Rochester
    Inventor: Lisa A. DeLouise
  • Patent number: 9244069
    Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: January 26, 2016
    Assignee: Dynex Technologies
    Inventors: Adrian Bunce, Andrew Fusellier
  • Patent number: 9217703
    Abstract: A photoacoustic flow cytometry (PAFC) device for the in vivo detection of cells circulating in blood or lymphatic vessels is described. Ultrasound transducers attached to the skin of an organism detect the photoacoustic ultrasound waves emitted by target objects in response to their illumination by at least one pulse of laser energy delivered using at least one wavelength. The wavelengths of the laser light pulse may be varied to optimize the absorption of the laser energy by the target object. Target objects detected by the device may be unlabelled biological cells or cell products, contrast agents, or biological cells labeled with one or more contrast agents.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: December 22, 2015
    Inventor: Vladimir Pavlovich Zharov
  • Patent number: 9186670
    Abstract: A microfluidic device and method is provided for handheld diagnostics and assays. The device includes a base having outer surface and a channel therethough for receiving fluid therein. The channel has input and output ports communicating with the outer surface. A lid is also provided. The lid has an outer surface, a first well having a port communicating with the outer surface of the lid, and a second well having a port communicating with the outer surface. The lid moveable between a first disengaged position and a second engaged position wherein the first port of the lid is adjacent the input port of the channel and the second port is adjacent the output port of the channel.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: November 17, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Erwin Berthier, Eric Sackmann, Peter Cavnar, David Beebe, David John Guckenberger
  • Patent number: 9151742
    Abstract: Disclosed herein are hand-held medical devices, such as blood glucose meters, that include a housing with a cassette compartment for receiving an exchangeable test tape cassette, a drive assembly comprising an electric motor and a gear arrangement adapted for rotating a tape spool of the test tape cassette, where the gear arrangement has a worm drive in which a worm meshes with a worm wheel and a multistage speed-reducing unit comprising a plurality of spur gears arranged between the worm wheel and an output gear that can be directly coupled to the tape spool.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: October 6, 2015
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Ming-Wen Chen
  • Patent number: 9089844
    Abstract: System, including methods, apparatus, and kits, for forming emulsions. The system may include an instrument and a microfluidic chip received by the instrument. The instrument may apply pressure to prospective emulsion phases held by the chip, to drive formation and collection of emulsions in the chip. In some embodiments, the instrument may stop applying pressure to the chip when a change in pressure meeting a predefined condition is detected by the instrument. The change may indicate that an endpoint of droplet generation has been reached.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: July 28, 2015
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Amy L. Hiddessen, Donald A. Masquelier, Kevin D. Ness, Benjamin J. Hindson, Anthony J. Makarewicz, Jr., Erin R. Chia
  • Patent number: 9068158
    Abstract: The present invention depicts an MRD-based reactor. The MRD-based reactor comprises of a means for containing a flowing media and reacting the same (reactor). The reactor is characterized by a continuous wall portion, and is in connection with at least one MRD, adapted for applying localized spectroscopy towards the media. MRD-based reactors, in which the MRD is at least partially inside the reactor or reaction media, and those in which the MRD accommodates the reactor, are also introduced. Lastly, the invention teaches an in situ method for controlling and analyzing of a reaction. The method comprises of providing an MRD-based reactor; applying a magnetic field within the reactor, especially for performing a plurality of localized spectroscopic measurements and either real time or offline analyzing and/or controlling of reactions in the flowing media.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: June 30, 2015
    Assignee: ASPECT AI LTD.
    Inventor: Uri Rapoport
  • Patent number: 9046356
    Abstract: A system and method for computer automated optimal lateral alignment of a spectrophotometer over a region of consistent color on a moving media or web for maintaining consistent color and or tonal qualities of a color application production process. The system consisting of a computer operated lateral traverse mechanism affixed to the press or color application equipment that is able to move the sensor laterally in small increments across the band of the color patches on the moving web or media, marking the lateral position each time it makes a light measurement, and therefrom calculating the optimal lateral alignment or position of the sensor for maintaining consistent color or density control during the color application process.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: June 2, 2015
    Assignee: Techkon USA LLC
    Inventors: George E. Adam, James L. Mourey
  • Publication number: 20150147804
    Abstract: The present invention relates to a biochemical analysis cartridge having improved operability. More particularly, the present invention provides a biochemical analysis cartridge including an insertion-type sample cartridge and a reaction cartridge receiving the insertion-type sample cartridge, in which,as the sample cartridge is inserted into the reaction cartridge,a reaction solution chamber moves toward a broken part of a covertape so as to automatically supply the reaction solution stored in the chamber. The biochemical analysis cartridge having improved operability according to the present invention can induce the mixing between a sample and a reaction solution by simply inserting them into the reaction cartridge and a reaction thereafter, thereby minimizing the process of a measurer to intervene in the assay, and subsequently improving user convenience and operability.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 28, 2015
    Inventors: Geun Sig CHA, Hakhyun NAM, Dongxuan SHEN, Joo Young CHO, Jihoon KIM
  • Publication number: 20150147777
    Abstract: An integrated fluidic device comprising includes an input chamber that provides an input of a sample fluid, and a first overspill chamber in fluid communication with the input chamber. A metering conduit is in fluid communication with the fluid input chamber and the first overspill chamber. The metering conduit meters a first metered volume of fluid from the sample fluid, and the first overspill chamber receives fluid in excess of the first metered volume of fluid. A second overspill chamber is in fluid communication with the metering conduit. The metering conduit meters a second metered volume of fluid from the first metered volume of fluid, and the second overspill chamber receives fluid from the first metered volume of fluid in excess of the second metered volume of fluid. The second overspill chamber has a fluid actuated closable valve for controlling the metering of the second metered volume of fluid.
    Type: Application
    Filed: November 22, 2013
    Publication date: May 28, 2015
    Inventor: Pamela Ann Dothie
  • Publication number: 20150147769
    Abstract: A method of testing a sample to determine a concentration of a target material included in the sample and a microfluidic device in which a reaction of the sample and a reagent occurs are provided. The method includes mixing a sample with a reagent that changes optical characteristics in accordance with a concentration of chlorine ions in the sample, and a capturing material that captures some of the chlorine ions in the sample; measuring the optical characteristics after mixing the sample with the reagent and the capturing material; and determining a concentration of the chlorine ions in the sample based on the measured optical characteristics.
    Type: Application
    Filed: October 30, 2014
    Publication date: May 28, 2015
    Inventors: Kui Hyun KIM, Taguchi TAKAYUKI, Sung Joon PARK, Chang Soo PARK, Sang Hyun BAEK, Tae Han LEE
  • Patent number: 9040304
    Abstract: A multi-channel system and methods for sorting particles according to one or more characteristics of the particles. The system includes multiple flow cytometry units, each unit can have a nozzle for producing a fluid stream containing a desired population of particles in a mixture of particles. Each of the units may be operable to sort said desired population of particles by interrogating the fluid stream with a beam of electromagnetic radiation and classifying particles based on one or more characteristics of the particles. The system also includes a common fluid delivery system for delivering sheath fluid to each flow cytometer unit for producing respective fluid streams.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: May 26, 2015
    Assignee: Inguran, LLC
    Inventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
  • Patent number: 9040250
    Abstract: A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with sepsis or septic shock a composition having a proanthocyanidin. A method of administering to a patient diagnosed with a gram negative bacterial infection a composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: May 26, 2015
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: James B Delehanty, Brandy J White, Baochuan Lin, Frances S Ligler
  • Publication number: 20150140577
    Abstract: An optical engine for use in a bench top flow cytometer, the optical engine comprising a set of lasers; a different set of beam shaping optics for each laser, wherein each set comprises two lenses to adjustably focus light horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same plane; collection optics for collecting fluorescence from the flow cell; filtration optics that filter the collected fluorescence from the flow cell into different detection channels according to wavelength ranges; and a detector for each detection channel that converts the filtered fluorescence to electrical signals, wherein electrical signals are processed so that the fluorescence from each laser at the different vertical positions is distinguished at the same detector.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 21, 2015
    Inventors: Nan Li, Ye Chen, Hyunsun Chung, Zengqiang Li, Xiaobo Wang
  • Publication number: 20150140551
    Abstract: A method for investigating one or a plurality of phase objects is described, in which a grid made up of elements is used, which is illuminated with light of a light source, the coherence length of which is larger than the average spacing of adjacent elements of the grid. A diffraction image of the illuminating light scattered on the grid is generated, whereby the one or the plurality of phase objects are placed in the light path between the light source and the grid and/or in the light path of the illuminating light scattered on the grid. At least a part of the diffraction image is detected by an optical sensor directly or after interaction with further optical components and converted into a signal. The signal is analysed further in order to ascertain information relating to the one or plurality of phase objects therefrom. A corresponding device is likewise described.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 21, 2015
    Inventors: Philipp Paulitschke, Joachim Radler
  • Publication number: 20150140648
    Abstract: The present invention provides an apparatus for analyzing particles in a solution including a unit configured to place a flow cell having a flow path for flowing a sample solution containing the particles; a unit configured to illuminate the sample solution flowing through the flow path of the flow cell; a photodetector that detects a scattered light and/or fluorescence generated from the particles in the sample solution; and a unit configured to analyze the particles based on their signal intensities detected by the photodetector, wherein the flow cell has the flow path formed in a substrate, a reflection plane is formed on the side surface of the flow path, the reflection plane leads the lights generated in the flow path of the flow cell and advancing in the substrate in-plane direction to a specified region of the surface of the flow cell, and the photodetector detects the light exiting from the specified region to the outside.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 21, 2015
    Inventor: Kazuo TAKEDA
  • Publication number: 20150140586
    Abstract: The invention relates to a device and a method for measuring neurotransmitters in the brain dialysate of mammals using enzymatic reactors specific to a certain neurotransmitter, which generate fluorescent derivatives when mixed. The mixture is introduced into an incubation chamber and passes through a temperature controlling system in order to set it to the optimum enzymatic reaction temperature, and the fluorescent derivative generated is passed through a flow fluorescence cell located inside the incubation chamber, where the liquid is impacted with a laser light source via an optical fibre. The fluorescence emitted is captured by a fluorescence detector that sends it to a processing system in order to obtain the corresponding values.
    Type: Application
    Filed: May 2, 2012
    Publication date: May 21, 2015
    Inventors: Alberto Morales Villagran, Daniel Morales Rodriguez
  • Patent number: 9034639
    Abstract: A device is provided for use with a tissue penetrating system and/or a metering device for measuring analyte levels. The device comprises a cartridge and a plurality of analyte detecting members mounted on the cartridge. The cartridge may have a radial disc shape. The cartridge may also be sized to fit within the metering device. The analyte detecting members may be optical system using fluorescence lifetime to determine analyte levels. In one embodiment, the device may also include a fluid spreader positioned over at least a portion of the analyte detecting member to urge fluid toward one of the detecting members. A plurality of analyte detecting members may be used. Each analyte detecting member may be a low volume device.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: May 19, 2015
    Inventors: Dominique M. Freeman, Dirk Boccker, Robert Jones, David Cullen, Malcolm MacLood, William Carlson, Michael J. Owen, Christopher Dryer
  • Publication number: 20150132789
    Abstract: Aspects of the present disclosure include methods and systems for assaying a sample for an analyte. Methods according to certain embodiments include illuminating a sample with a slit-shaped beam of light, detecting light transmitted through the sample, determining absorbance of the transmitted light at one or more wavelengths and calculating concentration of the analyte based on the absorbance to assay the sample for the analyte. Systems for practicing the subject methods are also described.
    Type: Application
    Filed: November 10, 2014
    Publication date: May 14, 2015
    Inventors: Scott Bornheimer, Edward Goldberg
  • Publication number: 20150133339
    Abstract: This invention provides a multiscale platform for coordinating behavior using synthetic biology. The platform reduces the impact of underlying noise, making outputs more coherent and reliable at the macroscopic level.
    Type: Application
    Filed: December 14, 2012
    Publication date: May 14, 2015
    Applicant: The Regents of the University of California
    Inventors: Arthur Prindle, Phillip Samayoa, Jeff Hasty
  • Publication number: 20150132791
    Abstract: A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.
    Type: Application
    Filed: January 13, 2015
    Publication date: May 14, 2015
    Inventors: Takaaki NAGAI, Noriyuki NARISADA, Daigo FUKUMA
  • Publication number: 20150132788
    Abstract: The invention relates to a method, a use and a kit for establishing the viability (ability to live) of biological samples using ageladine A. The invention is advantageously suitable for establishing the viability of biological samples which can otherwise be dyed in an intra-cellular manner by fluorescence dyes other than ageladine A not at all or only with difficulty. The invention is found to be very particularly advantageous for establishing the viability of eggs (ovaries) of the pig whipworm which are intended to be used for the treatment or prophylaxis of specific (gastroenterological) autoimmune diseases.
    Type: Application
    Filed: June 11, 2013
    Publication date: May 14, 2015
    Applicant: Ovamed GmbH
    Inventors: Detlev Goj, Ulf-Georg Bickmeyer, Guido Schramm
  • Patent number: 9028772
    Abstract: A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: May 12, 2015
    Assignee: Google Inc.
    Inventors: Huanfen Yao, Jeffrey George Linhardt, Babak Parviz
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Publication number: 20150125897
    Abstract: The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) ofindividual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).
    Type: Application
    Filed: October 2, 2014
    Publication date: May 7, 2015
    Applicant: Ludwig Maximilians Universität München
    Inventors: Stefan DUHR, Philipp Baaske
  • Publication number: 20150125945
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Application
    Filed: September 9, 2014
    Publication date: May 7, 2015
    Inventors: Elizabeth A. Holmes, John Kent Frankovich
  • Publication number: 20150125851
    Abstract: An optical sensor is configured to be used with trappers specifically bound to an object substance to detect whether the object substance exists or not in a specimen. The optical sensor includes a first metal layer made of gold having a lower surface and an upper surface which is configured to have an electromagnetic wave supplied thereto, and a second layer made of gold having an upper surface facing the lower surface of the first metal layer. A hollow area configured to be filled with the specimen is provided between the first metal layer and the second metal layer. The trappers are physically bonded to at least one of a lower side of the first metal layer and an upper side of the second metal layer. The thickness of the first metal layer is not smaller than 5 nm and not larger than 30 nm. The optical sensor has a small size and a simple structure.
    Type: Application
    Filed: April 8, 2013
    Publication date: May 7, 2015
    Inventors: Kiyoshi Hashimotodani, Yusuke Kitagawa
  • Publication number: 20150127078
    Abstract: A method of determining hypoxia in fetal scalp blood sampled during labor including the determination of total lactate dehydrogenase (LDH) in plasma obtained from the sample. The method can include the additional determination of K, Mg, Ca, AST, ALT, lactate in the plasma and/or blood. Increased values of one or more of LDH, Mg, Ca, AST, ALT, lactate are indicative of hypoxia in the fetus. Also disclosed is the use of a plasma separation apparatus in the method.
    Type: Application
    Filed: January 8, 2015
    Publication date: May 7, 2015
    Inventors: Mathias Karlsson, Sofia Hiort af Ornäs
  • Publication number: 20150125890
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Application
    Filed: March 27, 2014
    Publication date: May 7, 2015
    Applicant: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Connie C. WONG, Kevin E. LOEWKE, Thomas M. BAER, Rene A. REIJO-PERA, Barry BEHR