Rotating Vessel Patents (Class 435/291.8)
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Patent number: 9988596Abstract: Embodiments herein disclosed relate to a computer-controlled germination system built around a rotating vessel within which a germinating process takes place. The system includes automatable controls over air flow, water flow, temperature, and vessel rotation.Type: GrantFiled: February 23, 2016Date of Patent: June 5, 2018Assignee: SALISH COAST ENTERPRISES, INC.Inventors: William D. Redding, Wayne E. Carpenter
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Patent number: 8900855Abstract: A pH sensing bioreaction system is provided. The system includes a bioreaction container having a plastic wall and a pH sensor attached to the plastic wall. The pH sensor includes a sensor body having a flange that is sealingly attached to the plastic wall. The sensor body has a reference electrolyte therein and a first sensing element disposed in the reference electrolyte. The first sensing element is configured to contact both the reference electrolyte and a sample solution inside the bioreaction container. A second sensing element is positionable into an interior of the bioreaction container. The pH sensor has a plurality of configurations that include a booted configuration in which at least one sensing element is isolated from the interior of the bioreaction container, and a service configuration in which the at least one sensing element is fluidically coupled to the interior of the bioreaction container.Type: GrantFiled: December 14, 2011Date of Patent: December 2, 2014Assignee: Rosemount Analytical Inc.Inventors: Chang-Dong Feng, Barry W. Benton, Dave Anderson, Fong S. Yang, Wayne B. Wood
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Patent number: 8871501Abstract: A rotating drum that is made from a plurality of panels that are connected to form sub-cylinders that, in turn, are connected to form a drum cylinder. Drum heads are connected at both ends of the drum cylinders. The drum may be rotated using rotational means. In one preferred embodiment the rotational means is a tangential rotational drive system that engages drive tires that are positioned between sub-cylinders. A method for fabricating rotating drums. A business method of mass production of and/or distribution of rotating drums.Type: GrantFiled: May 1, 2008Date of Patent: October 28, 2014Inventor: Rick Claypool
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Patent number: 8076136Abstract: The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.Type: GrantFiled: March 29, 2007Date of Patent: December 13, 2011Assignees: The United States of America as represented by the United States National Aeronautics and Space Administration, University of Houston, Universities Space Research AssociationInventors: Mark S. F. Clarke, Alamelu Sundaresan, Neal R. Pellis
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Patent number: 7888111Abstract: An object of the present invention is to provide a cell culture vessel which is simple in structure and easy to handle, and is capable of preventing damage to the cells when separated, promoting transport of nutrients and excretion of effete matter, and elevating the culturing efficiency improving effect by the structural features. In order to attain the above object, there is provided a cell culture vessel including a culture section provided with a plurality of projections having an equivalent diameter smaller than the cells to be cultured and the culture section side walls enclosing the culture section, wherein the distance between an arbitrary position on the culture section/side wall boundary line and the nearest projection is smaller than the diameter of the cells to be cultured. The effect of the projections in the vessel given to the cultured cells is enhanced.Type: GrantFiled: November 9, 2009Date of Patent: February 15, 2011Assignee: Hitachi, Ltd.Inventors: Kosuke Kuwabara, Akihiro Miyauchi, Norihito Kuno
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Patent number: 7691625Abstract: An object of the present invention is to provide a cell culture vessel which is simple in structure and easy to handle, and is capable of preventing damage to the cells when separated, promoting transport of nutrients and excretion of effete matter, and elevating the culturing efficiency improving effect by the structural features. In order to attain the above object, there is provided a cell culture vessel including a culture section provided with a plurality of projections having an equivalent diameter smaller than the cells to be cultured and the culture section side walls enclosing the culture section, wherein the distance between an arbitrary position on the culture section/side wall boundary line and the nearest projection is smaller than the diameter of the cells to be cultured. The effect of the projections in the vessel given to the cultured cells is enhanced.Type: GrantFiled: May 26, 2006Date of Patent: April 6, 2010Assignee: Hitachi, Ltd.Inventors: Kosuke Kuwabara, Akihiro Miyauchi, Norihito Kuno
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Patent number: 7604987Abstract: The invention relates to a bioreactor comprising a chamber for containing cells or tissue cultures within a culture medium. The bioreactor also comprises a detector capable of detecting a change in one or more metabolites associated with growth of the cell or tissue cultures within the chamber and a chamber drive capable of rotating the chamber at a first speed about a first axis and a second speed about a second axis, the second axis being disposed at an angle relative to the first axis. In use, the magnitude of the first speed and the second speed are independently variable of each other.Type: GrantFiled: May 6, 2005Date of Patent: October 20, 2009Assignee: National University of SingaporeInventors: Dietmar W. Hutmacher, Swee Hin Teoh, Manoja Ranawake, Woon Shin Chong, Keng Soon Ting, Kay Chiang Chua, Than Myint, Chum Mok Puah, Toon Tien Foo, Jan-Thorsten Schantz
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Patent number: 7026131Abstract: This invention relates to clinical diagnostic assays, related optical bio-discs, and a disc-reading apparatus. The invention is directed to methods and apparatuses for performing immunohematology assays using an optical bio-disc analysis system. The invention is further directed to an optical bio-disc for performing an immunohematologic assay including a substrate having encoded information associated therewith. The encoded information may be readable by a disc drive assembly to control rotation of the disc. The disc may also include at least one target zone or capture zone associated with the substrate. The target zone is disposed at a predetermined location relative to a center of the substrate. The disc further includes a plurality of capture antibodies immobilized within the target zone, a flow channel, fluidic circuit, or analysis chamber associated with the target zone, and an input site in fluid communication with the analysis chamber.Type: GrantFiled: November 15, 2002Date of Patent: April 11, 2006Assignees: Nagaoka & Co., Ltd., Burstein Technologies, Inc.Inventors: Susan Newcomb Hurt, John Francis Gordon, Kevin Robert McIntyre
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Publication number: 20030129742Abstract: Apparatus and methods are directed to a perfusion culture system in which a rotating bioreactor is used to grow cells in a liquid culture medium, while these cells are attached to an adhesive-treated porous surface. As a result of this arrangement and its rotation, the attached cells divide, with one cell remaining attached to the substrate, while the other cell, a newborn cell is released. These newborn cells are of approximately the same age, that are collected upon leaving the bioreactor. The populations of newborn cells collected are of synchronous and are minimally, if at all, disturbed metabolically.Type: ApplicationFiled: February 24, 2003Publication date: July 10, 2003Inventors: Charles E. Helmstetter, Maureen Thornton