Testing For Sterility Condition Patents (Class 435/31)
  • Patent number: 10561751
    Abstract: A sterilization assembly of a mobile device includes a bacteria detection device, a microwave sterilization device, and a processor. The bacteria detection device detects a bacterial count on the mobile device by emitting light waves and receiving reflected light waves and analyzing a wavelength change in the reflected light waves. The microwave sterilization device emits microwaves to kill the bacteria. The processor sends a detection signal to the bacteria detection device to control the bacteria detection device to detect the bacterial count, and sends a sterilization signal to the microwave sterilization device to control the microwave sterilization device to emit the microwaves. The bacteria detection device sends detection feedback information to the processor. The microwave sterilization device sends sterilization feedback information to the processor.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: February 18, 2020
    Assignees: Fu Tai Hua Industry (Shenzhen) Co., Ltd., HON HAI PRECISION INDUSTRY CO., LTD.
    Inventor: Yong-Xing Yang
  • Patent number: 10457973
    Abstract: A method for rapidly determining effective sterilization, deimmunization, and/or disinfection of equipment and/or supplies by a device. The method includes providing a defined surrogate protein having a predetermined sequence representative of an infectious agent potentially contaminating the equipment and/or the supplies to be sterilized, deimmunized, and/or disinfected by the device. The defined surrogate protein having the predetermined sequence is subjected to sterilization, deimmunization, or disinfection. The effectiveness of the sterilization deimmunization, or disinfection is rapidly determined by determining if the defined surrogate protein has been destroyed.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: October 29, 2019
    Assignee: ONEighty°C Technologies Corporation
    Inventor: Theresa L. O'Keefe
  • Patent number: 10246731
    Abstract: A method for rapidly determining effective sterilization, deimmunization, and/or disinfection of equipment and/or supplies by a device. The method includes providing a defined surrogate protein having a predetermined sequence representative of an infectious agent potentially contaminating the equipment and/or the supplies to be sterilized, deimmunized, and/or disinfected by the device. The defined surrogate protein having the predetermined sequence is subjected to sterilization, deimmunization, or disinfection. The effectiveness of the sterilization deimmunization, or disinfection is rapidly determined by determining if the defined surrogate protein has been destroyed.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: April 2, 2019
    Assignee: ONEighty°C Technologies Corporation
    Inventor: Theresa L. O'Keefe
  • Patent number: 9750829
    Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: September 5, 2017
    Assignee: EMD Millipore Corporation
    Inventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
  • Patent number: 9611086
    Abstract: Surgical wrappers and related methods are provided. A reusable surgical wrapper can include a first layer that includes a fabric having at least one of synthetic fibers or synthetic yarns. In some embodiments, a surgical wrapper can include a first layer comprising a first fabric that repels fluids forming a first face of the surgical wrapper. A second layer can be provided that includes a second fabric forming a second face of the surgical wrapper. A seam binding can be disposed around at least a portion of an outer edge of the first fabric and an outer edge of the second fabric to join the first layer and the second layer to form a dual layered surgical wrapper.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: April 4, 2017
    Inventor: Rea Hinson, Jr.
  • Patent number: 9522001
    Abstract: Surgical appliance kit and system for releasably securing a surgical appliance to a surgical field and method of assembling the surgical appliance kit. The surgical appliance kit and system includes a surgical tray having the surgical appliance and a plurality of hook-and-loop attachment members disposed thereon. A cover is attached to the surgical tray and covers the surgical appliance and the plurality of attachment members. In use, a “hook” attachment member is adhesively attached to the surgical appliance and a “loop” attachment member is adhesively attached to the surgical field. The hook attachment member is placed into engagement with the loop attachment member. In this manner, the surgical appliance is releasably secured to the surgical field, so that the surgical appliance will not inadvertently fall from the surgical field.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: December 20, 2016
    Assignee: Operating Room Innovations, Inc.
    Inventors: Phong Duy Bui, Ruel Flores Salvador
  • Patent number: 9410180
    Abstract: A biological sterilization indicator (BI) system and method. The system can include a BI and a reading apparatus comprising a well. The BI can include a housing, which can include a first portion, and a second portion movable between a first “unactivated” position and a second “activated” position. The reading apparatus can detect at least one of (i) when the well is empty; (ii) when the biological sterilization indicator is positioned in the well with the second portion of the housing in the first position, and (iii) when the biological sterilization indicator is positioned in the well with the second portion of the housing in the second position. The method can include detecting at least one of the above conditions, which can be used to detect an activation status of the biological sterilization indicator.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: August 9, 2016
    Inventors: Jeffrey C. Pederson, Sailaja Chandrapati, Bryan S. Behun, Barry W. Robole, Leroy J. Longworth, Kaileen Chen
  • Patent number: 9260741
    Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: February 16, 2016
    Assignee: Bracco Imaging S.P.A.
    Inventors: Robert C. Williams, Jr., Patrice Marchildon
  • Patent number: 9228222
    Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: January 5, 2016
    Assignee: Bracco Imaging S.p.A.
    Inventors: Robert C. Williams, Jr., Patrice Marchildon
  • Patent number: 9228221
    Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: January 5, 2016
    Assignee: Bracco Imaging S.p.A.
    Inventors: Robert C. Williams, Jr., Patrice Marchildon
  • Patent number: 9228220
    Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: January 5, 2016
    Assignee: Bracco Imaging S.p.A.
    Inventors: Robert C. Williams, Jr., Patrice Marchildon
  • Publication number: 20150147773
    Abstract: A combined sterilization indicator incubator and reader system, including a sterilization indicator vial containing one of a variety of selected biological indicators and a liquid, at least two incubator blocks, each incubator block independently operable to incubate the sterilization indicator vial at a plurality of independently selectable temperatures, each of the incubator blocks including at least one heating element operable to heat the incubator block to any one of the plurality of independently selectable temperatures; a light source, a photodetector and a control system configured to operate the combined system to determine the efficacy of a variety of sterilization processes. The system calculates and compares a slope to a predetermined threshold slope for the biological indicator, and provides output based only on the comparison of the calculated slope to the predetermined threshold slope without first determining either a baseline or a minimum value of the output from the photodetector.
    Type: Application
    Filed: November 26, 2013
    Publication date: May 28, 2015
    Applicant: American Sterilizer Company
    Inventors: Phillip P. FRANCISKOVICH, Tricia A. CREGGER, Paul VODKIN
  • Publication number: 20150147408
    Abstract: A Method Validation Unit (MVU) for the evaluation of the level of sterilisation in a sterilisation method involving the use of a fluid at or near the supercritical pressure and temperature for that fluid, wherein the MVU comprises a sterilisation indicator housed within a gas-permeable container, wherein the sterilisation indicator comprises an indicator medium and a population of one or more colony forming units (CFUs), and wherein the indicator medium comprises one or more structural features representative of the internal structure of a material to be sterilised in the sterilisation method.
    Type: Application
    Filed: May 30, 2013
    Publication date: May 28, 2015
    Applicant: Austrialian Biotechnologies PTY. Limited
    Inventors: Simon Jonothan Berry, Sharon Bryce, Jerome Alon Goldberg
  • Patent number: 9012173
    Abstract: The disclosed invention relates to a method of making a sterilization indicator including depositing an electronically conductive material on a substrate using an ink jet printer and depositing a biological indicator on part or all of the electronically conductive material using the ink jet printer, and further relates to a method for monitoring a sterilization process including (A) exposing an article to be sterilized and a biological indicator to a sterilization medium during a sterilization process, the biological indicator comprising a cell with a plasma membrane in which the biological indicator is positioned on part or all of an electronically conductive material positioned on a substrate; and (B) measuring the membrane potential of the cell to detect the viability of the cell.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: April 21, 2015
    Assignee: American Sterilizer Company
    Inventors: Phillip P. Franciskovich, Tricia A. Cregger
  • Patent number: 8969029
    Abstract: A biological sterilization indicator, system, and methods of determining the effectiveness of a sterilization process. The biological sterilization indicator can include a locus of spores, a reservoir containing a liquid, and a sterilant path positioned to provide fluid communication between ambience and the locus of spores. The reservoir can have a closed state in which the reservoir is not in fluid communication with the locus of spores and an open state in which the reservoir is in fluid communication with the locus of spores. The biological sterilization indicator system can include the biological sterilization indicator and a detection device adapted to be coupled to the biological sterilization indicator. In some embodiments, the method can include assaying the spores for a detectable change in a characteristic, and detecting substantially all of the detectable change.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: March 3, 2015
    Assignee: 3M Innovative Properties Company
    Inventors: Sailaja Chandrapati, Jeffrey C. Pederson, Heather M. Webb, Jeffrey D. Smith, Kurt J. Halverson, Bryan S. Behun, Peter D. Ludowise
  • Publication number: 20140356899
    Abstract: A protocol process is provided for testing and evaluating Bacillus spores. The process includes isolating a sample of the spores, providing an environmental matrix of exposure condition elements, determining a midpoint for each control range between the low and high extremities, selecting condition elements from the matrix, with each condition element corresponding to a first condition, subjecting the sample to the condition elements from the matrix, counting survival spores for each condition element, performing a response surface methodology (RSM) analysis from the survival spores, and determining coefficients that satisfy a relation for k conditions. The matrix has control ranges of temperature, relative humidity and exposure duration, the control ranges extending from a low extremity to a high extremity. The first condition is one of the low and high range extremities and remaining conditions occupying the midpoint for a corresponding control range. All condition elements are uniquely distinguishable.
    Type: Application
    Filed: April 2, 2014
    Publication date: December 4, 2014
    Applicant: United States of America as represented by the Secretary of the Navy
    Inventors: Tony L. Buhr, Claire M. Wells, Alice A. Young, Edward J. Prokop, III, John R. Crigler
  • Patent number: 8859222
    Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: October 14, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Leo Martis, Mehul Patel, Joseph A. Giertych, James W. Mongoven, Jacqueline A. Kunzier, William F. Owen
  • Publication number: 20140273073
    Abstract: A sterilization indicator for oxidative sterilants, comprising a first compartment comprising spores of one or more microorganism species, wherein the spores have been pretreated with and comprises a compound comprising a transition metal ion that is reactive with an oxidative sterilant; a second compartment comprising a growth medium and adapted to combine contents of the first compartment with contents of the second compartment for incubation after the sterilization indicator has been exposed to an oxidative sterilant; and an agent disposed in the growth medium and selected to indicate viability of the spores after the sterilization indicator has been exposed to the oxidative sterilant.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: AMERICAN STERILIZER COMPANY
    Inventors: Phillip P. Franciskovich, Tricia A. Cregger
  • Publication number: 20140273072
    Abstract: A sterilization indicator, including a first compartment containing a genetically engineered biological indicator, and a second compartment containing an enzyme substrate, the second compartment adapted to maintain the enzyme substrate separate from the biological indicator during sterilization, and to permit the enzyme substrate to contact the biological indicator after the biological indicator has been exposed to the sterilization medium; in which the genetically engineered biological indicator comprises at least one test organism and at least one reporter gene suitable for producing an indicator enzyme, the reporter gene being taken up by the test organism; and the test organism is free of any active or activatable repressor gene that would inhibit expression of the reporter gene if present in the test organism or sterilization indicator, and the indicator enzyme and the enzyme substrate are selected such that enzymatic action of the indicator enzyme upon the enzyme substrate yields a detectable signal.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: AMERICAN STERILIZER COMPANY
    Inventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava
  • Patent number: 8828714
    Abstract: The sterilizing effect of particle irradiation on microorganisms for the sterilizing treatment thereof can be evaluated. The evaluation can be done by supplying microorganisms in the space inside a container (8), allowing particles (7) for the sterilizing treatment of microorganisms to irradiate the microorganisms, sampling the microorganisms by a sampling means (6) after the irradiation of the particles (7) and measuring the sampled microorganisms. The microorganisms as the subject for the sterilizing treatment can be a combination of one or more members selected from the group consisting of bacteria, mycete, viruses and allergens. As the particles, for example, positive ions, negative ions, and gases of positive ions and negative ions in mixture, charged particles such as ? rays and ? rays, various plasma gas particles, particles such as ozone and radical particles, and particles of chemical agent can be used.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: September 9, 2014
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Kazuo Nishikawa, Hisaharu Yagi, Yoshihiro Shimizu, Tetsuyuki Ohtani, Hideo Nojima, Miyuki Aoki
  • Patent number: 8822174
    Abstract: A sterilization indicator for oxidative sterilants, comprising a first compartment comprising spores of one or more microorganism species, wherein the spores have been pretreated with and comprises a compound comprising a transition metal ion that is reactive with an oxidative sterilant; a second compartment comprising a growth medium and adapted to combine contents of the first compartment with contents of the second compartment for incubation after the sterilization indicator has been exposed to an oxidative sterilant; and an agent disposed in the growth medium and selected to indicate viability of the spores after the sterilization indicator has been exposed to the oxidative sterilant.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 2, 2014
    Assignee: American Sterilizer Company
    Inventors: Phillip P. Franciskovich, Tricia A. Cregger
  • Patent number: 8822173
    Abstract: The present invention relates to a wound dressing or a wound swab, which allows the detection of at least three enzymes selected from the group consisting of lysosyme, elastase, cathepsin G and myeloperoxidase using colored substrate agents for these enzymes. These enzyme substrates can be bound to medically acceptable polymers or fibers.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: September 2, 2014
    Assignee: Eva Wehrschutz-Sigl
    Inventor: Eva Wehrschütz-Sigl
  • Publication number: 20140227735
    Abstract: A biological indicator for determining the effectiveness of a sterilization process is disclosed having a package and carrier integral therewith. The package includes a first sheet and a second sheet having a bottom portion, side portions and a top portion. The first and second sheets are joined together generally along a periphery of the first and second sheets by a peelable adhesive. A carrier having a plurality of spores thereon for determining the effectiveness of a sterilization process is attached to the package between the first and second sheets and at least a portion of the resealable adhesive. The package may be opened and subsequently partially or fully closed to enclose the carrier.
    Type: Application
    Filed: April 21, 2014
    Publication date: August 14, 2014
    Inventor: Joseph P. Dalmasso
  • Patent number: 8802392
    Abstract: The present invention provides method of detecting a predetermined biological activity. The method includes using an aqueous mixture comprising a first indicator reagent with a first absorption spectrum and a second indicator reagent. The second indicator reagent is converted by the predetermined biological activity to a second biological derivative with a second emission spectrum. The first absorbance spectrum includes detectable absorbance in at least a portion of wavelengths present in the second emission spectrum. The first indicator reagent is received and concentrated from an aqueous liquid by a substrate, facilitating the detection of the second biological derivative.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: August 12, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Sailaja Chandrapati, Heather M. Webb, Jeffrey C. Pederson, Kurt J. Halverson, Brian R. Engel
  • Patent number: 8785141
    Abstract: The invention aims at providing an adsorbent for bacterial toxins, a method for removal of such toxins by adsorption, and an adsorber packed with said adsorbent. Provided are an adsorbent for bacterial toxins, which comprises a water-insoluble porous material having a mode of pore radius of 20 angstroms to 1,000 angstroms, a method for removal of bacterial toxins using said adsorbent, and an adsorber packed with said adsorbent.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: July 22, 2014
    Assignee: Kaneka Corporation
    Inventors: Tamiji Fujimoto, Fumiyasu Hirai, Shigeo Furuyoshi
  • Patent number: 8778629
    Abstract: A sterility test method includes: selecting strain and culture medium, preparing bacterial cultures, transcribing fingerprint characteristics in thermograms as indices to verify the characteristics, drawing the thermodynamic parameters of the thermogram, determining the positive judgment index and performing sterility test for the samples. A fully-enclosed bacteria collecting ampoule incubator includes bacteria collecting ampoule system, sample and liquid feeding system and peristalsis liquid discharge system. The sample and liquid feeding system is connected with the bacteria collecting ampoule system by the liquid intake tube; and the bacteria collecting ampoule system is connected with the peristalsis liquid discharge system by the liquid drainage tube. The invention is characterized by short inspection time, high sensitivity, high automation and accurate test results on microbial contamination. It can also provide the overall process curve on the growth conditions.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: July 15, 2014
    Assignee: 302 Military Hospital of China
    Inventors: Dan Yan, Xiaohe Xiao, Ping Zhang, Yongshen Ren, Cheng Jin
  • Patent number: 8765398
    Abstract: A biological indicator for determining the effectiveness of a sterilization process is disclosed having a package and carrier integral therewith. The package includes a first sheet and a second sheet having a bottom portion, side portions and a top portion. The first and second sheets are joined together generally along a periphery of the first and second sheets by a peelable adhesive. A carrier having a plurality of spores thereon for determining the effectiveness of a sterilization process is attached to the package between the first and second sheets and at least a portion of the resealable adhesive. The package may be opened and subsequently partially or fully closed to enclose the carrier.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: July 1, 2014
    Assignee: Mesa Laboratories, Inc.
    Inventor: Joseph P. Dalmasso
  • Publication number: 20140171444
    Abstract: The present invention provides aryl- or heteroaryl-diketo acid compounds effective to inhibit an activity of a Mycobacterial malate synthase enzyme or to inhibit a malate synthase activity in other bacteria having the enzyme. The compounds may be phenyl- naphthyl-, or thienyl-substituted diketo acids and carboxylate derivatives thereof. Also provided are methods of treating tuberculosis or other pathophysiological conditions associated with a malate synthase enzyme with the inhibitory compounds and methods of in silico design of the inhibitory compounds. In addition, the present invention provides the inhibitory compounds designed by this method. Furthermore, three-dimensional X-ray crystal structures of the Mycobacterial malate synthase complexed with the inhibitory compounds are provided. Further still a method for stabilizing an aromatic or heteroaromatic diketo acid or its prodrug or close analog in solution by derivatizing at least the ortho position on the aromatic ring is provided.
    Type: Application
    Filed: March 3, 2014
    Publication date: June 19, 2014
    Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Joel S. Freundlich, James C. Sacchettini, Inna V. Kriger, Thomas R. Ioerger, Vijay Gawandi
  • Publication number: 20140162307
    Abstract: The disclosed invention relates to a method of making a sterilization indicator including depositing an electronically conductive material on a substrate using an ink jet printer and depositing a biological indicator on part or all of the electronically conductive material using the ink jet printer, and further relates to a method for monitoring a sterilization process including (A) exposing an article to be sterilized and a biological indicator to a sterilization medium during a sterilization process, the biological indicator comprising a cell with a plasma membrane in which the biological indicator is positioned on part or all of an electronically conductive material positioned on a substrate; and (B) measuring the membrane potential of the cell to detect the viability of the cell.
    Type: Application
    Filed: February 14, 2014
    Publication date: June 12, 2014
    Applicant: American Sterilizer Company
    Inventors: Phillip P. Franciskovich, Tricia A. Cregger
  • Publication number: 20140154670
    Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.
    Type: Application
    Filed: December 5, 2013
    Publication date: June 5, 2014
    Applicant: Bracco Imaging S.p.A
    Inventors: Robert C. Williams, JR., Patrice Marchildon
  • Publication number: 20140154671
    Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.
    Type: Application
    Filed: December 5, 2013
    Publication date: June 5, 2014
    Applicant: Bracco Imaging S.p.A
    Inventors: Robert C. Williams, JR., Patrice Marchildon
  • Publication number: 20140099233
    Abstract: The present disclosure provides a monitoring device comprising a test composition, a test element comprising a test portion to which the test composition is releasably adhered, a detection reagent, and a container comprising a first end with an opening and a second end opposite the first end. The test composition comprises a predetermined quantity of tracer analyte. The container is configured to receive the test portion and configured to be operationally coupled to an analytical instrument. The tracer analyte and the detection reagent each are capable of participating in one or more chemical reaction that results in the formation of a detectable product. A method of using the monitoring device to assess the efficacy of a washing process is also provided.
    Type: Application
    Filed: October 1, 2013
    Publication date: April 10, 2014
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: G. MARCO BOMMARITO, MANJIRI T. KSHIRSAGAR, TING LIU, TIMOTHY J. NIES, SWARNALATHA SWAMINATHAN
  • Patent number: 8673590
    Abstract: The invention provides a microorganism having an ability to produce a protein having a dipeptide synthesizing activity and in which an activity of the protein to transport a dipeptide in a microbial cell to theoutside of the microbial cell is higher than that of a parental strain.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: March 18, 2014
    Assignee: Kyowa Hakko Bio Co., Ltd.
    Inventors: Mikiro Hayashi, Kazuhiko Tabata, Makoto Yagasaki, Yoshiyuki Yonetani
  • Publication number: 20130337490
    Abstract: The present disclosure provides a system for inspecting a package (1040) having a substance subject to spoilage. An electromagnetic signal (e.g., a terahertz frequency signal) is directed to the package (1040), and an attenuated signal is received and sampled to generate a set of data points. A peak within the set of data points is detected, and the data points are shifted with respect to time to align the detected peak with a predetermined time. The set of shifted data points are compared to a mathematical model to determine whether the substance in the package (1040) is spoiled.
    Type: Application
    Filed: December 13, 2011
    Publication date: December 19, 2013
    Applicant: ABBOTT LABORATORIES
    Inventors: Alvin Horatio Mundell, Barbara Ann Ribble
  • Publication number: 20130323779
    Abstract: Presently disclosed is a lighting system and methods of using the lighting system for in vitro potency assay for photofrin. The lighting system includes a lamp housing, a first lens, an infrared absorbing filter, an optical filter, and a second lens. The lamp housing includes a lamp and a light-port. In operation, broad spectrum light from the lamp exits the lamp housing by passing through the light-port. The first lens then collimates the broad spectrum light that exits the lamp housing through the light-port. The infrared absorbing filter then passes a first portion of the collimated broad spectrum light to the optical filter and absorbs infrared light of the broad spectrum light. The optical filter then passes a second portion of the collimated broad spectrum light to the second lens. The second lens then disperses the second portion of the collimated light to provide uniform irradiation of a cell culture plate. A method of using the lighting system for studying a photosensitizer is also disclosed.
    Type: Application
    Filed: November 29, 2012
    Publication date: December 5, 2013
    Applicant: PINNACLE BIOLOGICS, INC.
    Inventor: Michael S. Roberts
  • Publication number: 20130302849
    Abstract: A biological sterilization indicator (BI) and method of using same. The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a first fluid path positioned to fluidly couple the first chamber and the second chamber, and a second fluid path positioned to allow displaced gas to move out of the second chamber. The method can include moving displaced gas out of the second chamber via the second fluid path as a sterilant is moved into the second chamber via the first fluid path and/or as the liquid is moved into the second chamber via the first fluid path.
    Type: Application
    Filed: October 28, 2011
    Publication date: November 14, 2013
    Inventors: Jeffrey D. Smith, Jeffrey C. Pederson, Sailaja Chandrapati, RuthAnn R. Duda
  • Publication number: 20130273593
    Abstract: Sterilization indicators that include a neutralizer, such indicators useful for testing the effectiveness of a sterilization procedure by measuring the activity of an active enzyme whose activity is correlated with the survival of microorganisms.
    Type: Application
    Filed: December 20, 2011
    Publication date: October 17, 2013
    Applicant: 3M Innovative Properties Company
    Inventors: William E. Foltz, Francois Ahimou, G. Marco Bommarito, Robert A. Asmus, Louis C. Haddad, Tushar A. Kshirsagar
  • Publication number: 20130273594
    Abstract: Sterilization indicators that include a unique porous carrier, such indicators useful for testing the effectiveness of a sterilization procedure by measuring the activity of an active enzyme whose activity is correlated with the survival of microorganisms.
    Type: Application
    Filed: December 20, 2011
    Publication date: October 17, 2013
    Applicant: 3Innovative Properties Company
    Inventors: Francois Ahimou, G. Marco Bommarito, Tushar A. Kshirsagar
  • Patent number: 8546097
    Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: October 1, 2013
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Leo Martis, Mehul Patel, Joseph A. Giertych, James W. Mongoven, Jacqueline A. Kunzler, William F. Owen, Jr.
  • Patent number: 8541195
    Abstract: A testing unit and a method of testing a sterilization packaging unit for microbial contamination of sterilized objects after they have been sterilized are disclosed. The testing unit includes a dry matrix for accommodating a nutrient medium and a receptacle containing a liquid. By applying the liquid onto the matrix, the matrix is provided with a nutrient medium. In the method, the testing unit is inserted into the sterilization packaging unit which is sterilized and stored. At a desired point in time, the receptacle is opened in order to produce the nutrient medium in the matrix. After a possible multiplication of microbes on the matrix, an observation of microbes takes place. The invention also relates to a sterilization packaging unit which has a rigid outer casing and is suitable for the application of the method.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: September 24, 2013
    Inventor: Hartmut Dunkelberg
  • Patent number: 8541196
    Abstract: The present invention provides a device for activating a self-contained biological indicator. The biological indicator includes a casing, an ampule having a growth-promoting medium disposed therein and microorganisms. The ampule and microorganisms are disposed within the casing. The device is comprised of a first lever arm having a cavity formed therein. The cavity is dimensioned to receive a biological indicator. A second lever arm has a protrusion extending from a surface thereof and is moveable relative to the first lever arm to deform a casing of the biological indicator thereby fracturing an ampule in the casing and exposing microorganisms in the casing to a growth-promoting medium in the ampule of the biological indicator.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: September 24, 2013
    Assignee: American Sterilizer Company
    Inventors: Joseph T. Sestak, Peter J. Buczynski
  • Patent number: 8541224
    Abstract: A method for retention testing sterilizing grade filters comprises: a) providing a stock of Acholeplasma laidlawii; b) growing up the stock of A. laidlawii for about 24 hours or less in a single serum-free growth medium that supports cell growth to a high titer and yields a cellular morphology where the cells are small, deaggregated and spherical, thereby producing a bacterial culture; c) challenging a test filter by filtering the bacterial culture through the test filter at a known challenge level, thereby producing a filtrate downstream of the test filter; and d) detecting concentration of A. laidlawii in the filtrate. Serum-free growth media for cultivating or storing A. laidlawii are also described.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: September 24, 2013
    Assignee: EMD Millipore Corporation
    Inventors: Shawn Bates, Kerry Roche Lentine, Nada Bsat
  • Patent number: 8530184
    Abstract: The disclosed invention relates to a method for monitoring a sterilization process. The method includes (A) exposing an article to be sterilized and a biological indicator to a sterilization medium during a sterilization process, the biological indicator comprising a cell with a plasma membrane; and (B) incubating the cell and measuring the membrane potential of the cell to detect change in the membrane potential.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: September 10, 2013
    Assignee: American Sterilizer Company
    Inventors: Phillip P. Franciskovich, Tricia A. Cregger
  • Publication number: 20130210048
    Abstract: A method of detecting a biological activity is provided. The method includes contacting; in a liquid medium selected to facilitate a predetermined biological activity; a sample, an indicator reagent, and a substrate that receives and concentrates a biological derivative of the indicator reagent. The method further includes observing a portion of the substrate to detect the biological derivative. The method can be used to detect the presence or absence of a target cell.
    Type: Application
    Filed: October 28, 2011
    Publication date: August 15, 2013
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Sailaja Chandrapati, Heather M. Webb, Jeffrey C. Pederson, Brian J. Engel
  • Patent number: 8486691
    Abstract: A device useful in determining the efficacy of a chemical sterilization process includes a dead end cavity closed by an access cap having a port coupled to a challenge tube defining the only path by which a substantial quantity of sterilant can reach the cavity. A biological indicator is located within the cavity and a chemical indicator is also provided. These indicators, and particularly the biological indicator, provide an indication of whether chemical sterilant would reach all interior exposed surfaces of a load in sufficient concentrations to adequately sterilize the load.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: July 16, 2013
    Assignee: Sterilucent, Inc.
    Inventors: Kent Larson, Patrick LaValley, Jami McLaren, Steven J. Olson
  • Publication number: 20130171684
    Abstract: An aerosol deposition apparatus is described for reproducibly preparing standardized coupon surfaces, which mimic aerosol deposited materials in an uncontrolled environment. The dome shaped apparatus is placed over the surfaces and an aerosol is delivered to the apex of the dome. The aerosol deposited surfaces may be used as standards for evaluating decontamination methods.
    Type: Application
    Filed: January 3, 2012
    Publication date: July 4, 2013
    Inventors: Michael Worth Calfee, Sang Don Lee, Shawn Patrick Ryan
  • Publication number: 20130136801
    Abstract: This disclosure describes example antimicrobial compositions that may be used in combination with IV port cleansing caps, protective caps, or nasal decolonizer devices. According to another implementations, the disclosure describes that the antimicrobial composition may provide an indication that it has come into contact with a contaminant by bubbling or foam on a surface that is being cleaned. According to another implementation, the disclosure describes that the antimicrobial composition may leave a residual film or barrier to inhibit the recontamination of a surface that has been cleaned.
    Type: Application
    Filed: November 28, 2012
    Publication date: May 30, 2013
    Applicant: HYPROTEK, INC.
    Inventor: Hyprotek, Inc.
  • Patent number: 8389233
    Abstract: Provided are methods for sampling, testing and validating test lots, comprising: assembling a plurality of product portions from each of a plurality of test lots and combining the portions to provide a corresponding set of test lot samples; enriching the test lot samples; removing portions of each enriched sample, and combining the removed portions to provide a modular composite sample; and testing of the modular composite sample, and individual testing of the enriched test lot samples, using at least one suitable detection assay for a target microbe or organism, wherein when such testing is negative all test lots are validated, and wherein when such testing is positive with respect to the modular composite sample, or with respect to an individual enriched test lot sample, individual test lots may nonetheless yet be validated by further testing of a portion of respective initially-negative enriched test lot samples and obtaining negative results.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: March 5, 2013
    Assignee: Institute for Environmental Health, Inc.
    Inventor: Mansour Samadpour
  • Publication number: 20130035262
    Abstract: Determining the microorganism load of a substance may be conducted readily using one or more integrated computational elements. By determining a substance's microorganism load, the substance's suitability for a variety of applications may be ascertained. Methods for determining the microorganism load of a substance using one or more integrated computational elements can comprise: providing a substance comprising a plurality of viable microorganisms; exposing the substance to a pulsed light source for a sufficient length of time to form at least some non-viable microorganisms; and determining a microorganism load of the substance using one or more integrated computational elements.
    Type: Application
    Filed: July 10, 2012
    Publication date: February 7, 2013
    Inventors: Robert P. Freese, Johanna A. Haggstrom, Jason E. Bryant, Rory D. Daussin
  • Patent number: 8361741
    Abstract: A method for retention testing sterilizing grade filters comprises: a) providing a stock of Acholeplasma laidlawii; b) growing up the stock of A. laidlawii for about 24 hours or less in a single serum-free growth medium that supports cell growth to a high titer and yields a cellular morphology where the cells are small, deaggregated and spherical, thereby producing a bacterial culture; c) challenging a test filter by filtering the bacterial culture through the test filter at a known challenge level, thereby producing a filtrate downstream of the test filter; and d) detecting concentration of A. laidlawii in the filtrate. Serum-free growth media for cultivating or storing A. laidlawii are also described.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: January 29, 2013
    Assignee: Millipore Corporation
    Inventors: Shawn Bates, Kerry Roche Lentine, Nada Bsat