Involving Viable Micro-organism Patents (Class 435/29)
  • Patent number: 10149640
    Abstract: Disclosed herein are embodiments of methods and techniques for measuring oxygen levels of an implant. The implant can have a plurality of oxygen-sensitive microparticles incorporated throughout. The oxygen-sensitive microparticles can receive light and emit excitation light in response. The levels of excitation light emitted can be directly related to oxygen concentration in the implant.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: December 11, 2018
    Assignee: The Regents of the University of California
    Inventors: Elliot Botvinick, John Weidling
  • Patent number: 10139396
    Abstract: A method of noninvasively detecting plant pathogenic virus and an electronic apparatus thereof are provided. The method is adapted to the electronic apparatus for detecting pathogenic virus in plants. The method includes the following steps. An excitation light beam is projected to the plant, and a reaction light emitted by the plant in response to the excitation light is received. An analytic optical spectrum corresponding to the reaction light is obtained, and whether the plant has the pathogenic virus or not is determined according to the analytic optical spectrum.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: November 27, 2018
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Jen-Jie Chieh, Yen-Hsiang Wang, Shien-Kuei Liaw, Wen-Chun Wei, Ming-Hsien Chiang
  • Patent number: 10139419
    Abstract: Methods of detecting A? oligomers, such as may be present in a biological sample are described. The methods include detection using flow cytometry, detection using synthetic A? oligomers and/or in vitro methods detecting A? oligomers associated with cells.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: November 27, 2018
    Assignee: SYSTEM OF SYSTEMS ANALYTICS, INC.
    Inventors: Richard O. Cliff, Robert W. Flower, Evgenia G. Matveeva
  • Patent number: 10131881
    Abstract: The present invention relates to a medium composition for the dedifferentiation of induced pluripotency stem cells, containing a phlorotannin fraction extracted and isolated from one type of brown algae selected from the group consisting of Ecklonia cava, Dictyopteris prolifera, Dictyota coriacea, Sargassum horneri, Ishige okamurai and the like. In addition, the present invention relates to a method for preparing induced pluripotency stem cells by using the medium composition. Induced pluripotency stem cells can be safely, easily and effectively prepared by using mesenchymal stem cells by using the medium composition of the present invention, and the prepared induced pluripotency stem cells can be differentiated into various cells, and thus can be useful as a cell therapeutic agent.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: November 20, 2018
    Assignee: BBHC
    Inventors: Sang Yeon Lee, Won Ju Jung, Ho Bin Kim, Min Sun Oh, Kye Ho Lee
  • Patent number: 10127336
    Abstract: A method of determining an uncertainty in the position of a domain within a self-assembly block copolymer (BCP) feature. The method includes simulating a BCP feature, calculating a minimum energy position of a first domain within the simulated BCP feature, simulating the application of a potential that causes the position of the first domain to be displaced from the minimum energy position, simulating release of the potential back toward the minimum energy, recording a plurality of energies of the BCP feature during the release and recording at each of the plurality of energies a displacement of the first domain from the minimum energy position, calculating, from the recorded energies and recorded displacements, a probability distribution indicating a probability of the first domain being displaced from the minimum energy position, and, from the probability distribution, calculating an uncertainty in the position of the first domain within the BCP feature.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: November 13, 2018
    Assignee: ASML NETHERLANDS B.V.
    Inventors: Sander Frederik Wuister, Tamara Druzhinina, Jan Van Male, Joanne Klein-Wolterink, Davide Ambesi
  • Patent number: 10119107
    Abstract: The present invention are directed to a novel automated cell bioprinter and related methods for making three-dimensional tissue constructs with spatial organization of cells that provides: (i) organized cell placement and spatial assembly of multiple cell types in a reproducible manner (ii) direct and non-contact assembly of multiple cell types and/or cell layers without exerting damaging forces on the cells or tissues, (iii) retention of cell viability and functionality during assembly steps and long periods of culture, (iv) minimal use of harmful and toxic chemicals such as profuse amounts of mineral oil and buffer reagent, and (v) efficient layer-to-layer assembly of cell layers within the three-dimensional construct while (vi) avoiding the use of complicated surface treatments that prevents scale-up, and (vii) avoiding mutation-inducing radiations such as UV used to photocrosslink hydrogels.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: November 6, 2018
    Assignee: The University of Akron
    Inventors: Hossein Tavana, David Petrak
  • Patent number: 10117866
    Abstract: Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: November 6, 2018
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Zhigang He, Kevin Park, Kai Liu, Yang Hu
  • Patent number: 10113978
    Abstract: An interfacial electric field intensity of a surface is measured by covalently binding a monolayer of a voltage sensitive chromophore to the surface and irradiating it with actinic radiation while it is in contact with a liquid and measuring a first fluorescence emission spectrum. A solution of the voltage sensitive chromophore dissolved in a sample of the liquid is also irradiated with actinic radiation and a second fluorescence emission spectrum is measured. The first and second fluorescence emission spectra are compared to determine the interfacial electric field intensity.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: October 30, 2018
    Assignee: EASTMAN KODAK COMPANY
    Inventors: Allan Wexler, Steven C. Switalski, Grace Ann Bennett, Kimberly S. Lindner
  • Patent number: 10105709
    Abstract: A specimen holding and positioning apparatus operable to substantially non-movably maintain a specimen (e.g., an excised tissue specimen) in a fixed or stable orientation with respect to the apparatus during imaging operations (e.g., x-ray imaging), transport (e.g., from a surgery room to a pathologist's laboratory), and the like for use in facilitating accurate detection and diagnosis of cancers and/or other abnormalities of the specimen.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: October 23, 2018
    Assignee: Hologic, Inc.
    Inventors: Ciaran Purdy, Donogh O'Driscoll
  • Patent number: 10094745
    Abstract: Swabs, materials and methods of making the same include randomly arranged sea-island bicomponent fibers which have randomly splayed terminal ends. According to certain embodiments, swabs and methods of using such swabs are provided so as to collect and release a biological sample comprising a liquid, wherein the swab includes an applicator and sea-island bicomponent fibers, and wherein at least about 50% of the fibers possess randomly splayed terminal ends of the islands of the bicomponent fibers along a length of about 10% or less from such ends.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: October 9, 2018
    Assignee: PURITAN MEDICAL PRODUCTS COMPANY, LLC
    Inventors: Terry Young, Timothy Templet, Paul Dube, Todd Dixon, Armand F. Lewis, Yong K. Kim
  • Patent number: 10094744
    Abstract: Swabs, materials and methods of making same, include randomly arranged sea-island bicomponent fibers. According to certain embodiments, swabs and methods of using such swabs are provided so as to collect and release a biological sample comprising a flock fiber tipped applicator wherein the flock fibers are sea-island bicomponent fibers attached to an end portion of the applicator with an adhesive selected from the group consisting of a photocurable acrylic adhesive and a polyurethane adhesive, the bicomponent fibers being structurally stable in water and the sea component of the bicomponent flock fibers being intact.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: October 9, 2018
    Assignee: PURITAN MEDICAL PRODUCTS COMPANY, LLC
    Inventors: Terry Young, Timothy Templet, Paul Dube, Todd Dixon, Armand F. Lewis, Yong K. Kim
  • Patent number: 10082511
    Abstract: The present invention includes a method and apparatus for measuring the transport of analytes from living, biological cells through a cell barrier, which includes, but is not limited to, steps of providing the living, biological cells loaded with analytes, unloading at least a portion of said analytes from the cells through ion channels, removing unloaded analyte remaining in the cells, and measuring the analytes using x-ray fluorescence, specifically wherein the measurement uses an energy dispersive x-ray fluorescence spectrometer equipped with a microfocus x-ray tube. These steps may be repeated so that multiple measurements can be obtained over a period of time.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: September 25, 2018
    Assignee: ICAGEN, INC.
    Inventors: Benjamin P. Warner, Lori J. Peterson, Jennifer A. Berger, Eva R. Birnbaum, Rebecca L. E. Miller
  • Patent number: 10076574
    Abstract: Methods for treating a subject in need thereof are provided which include administering a pharmaceutical composition comprising a protein transduction reagent-modified reprogramming protein to the subject, wherein the protein transduction reagent is non-covalently bound to the reprogramming protein and wherein the protein transduction reagent comprises a cation reagent and a lipid. According to aspects, such methods provide delivery of protein-transduction reagent-modified reprogramming proteins to cancer cells, such as tumor cells, as well as diseased cells of diseased tissues and provide in vivo conversion of diseased cells into normal cells via protein-induced in situ cell reprogramming without administration of nucleic acids to the subject.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: September 18, 2018
    Assignee: Wayne State University
    Inventors: Jianjun Wang, Qianqian Li, Michael Chopp, Feng Jiang, Guojun Wu
  • Patent number: 10076752
    Abstract: A method of flowing a fluid with a tracer in a microfluidic channel of an assay device and detecting the tracer for determining the channel location or condition of the channel.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: September 18, 2018
    Assignee: CyVek, Inc.
    Inventors: Martin A. Putnam, Jeffrey T. Branciforte, Charles O. Stanwood
  • Patent number: 10071373
    Abstract: A lateral-flow assay device includes a substrate having a sample addition zone and a wash addition zone downstream thereof along a fluid flow path through which a sample flows. The fluid flow path is configured to receive a wash fluid in the wash addition zone. A hydrophilic surface is arranged in the wash addition zone. Flow constriction(s) are spaced apart from the fluid flow path and arranged to define, with the hydrophilic surface, a reservoir configured to retain the wash fluid by formation of a meniscus between the hydrophilic surface and the flow constriction(s). The fluid flow path draws the wash fluid from the reservoir by capillary pressure. Apparatus for analyzing a fluidic sample and methods of displacing a fluidic sample in a fluid flow path of an assay device are also described.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: September 11, 2018
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Zhong Ding, Edward R. Scalice, Daniel P. Salotto
  • Patent number: 10064949
    Abstract: The present embodiments may relate to topically delivered compounded medications for the treatment of scar tissue, skin disorders, and/or other ailments. In one aspect, a transdermal cream or gel may provide for the effective administration of multiple medications simultaneously. Preferably, a silicone-based gel may be provided as a base composition and may have a non-zero percentage of silicone or silicone variant. The silicone-based gel may comprise cyclopentasiloxane, polysilicone-11, dimethicone, and C30-45 alkyl cetearyl dimethicone crosspolymer, and include several active ingredients, such as glucocorticoids, antihistamines, and nerve depressants. The silicone-based gel may include a combination of fluticasone, loratadine, and gabapentin. The concentrations of fluticasone and loratadine may be relatively low, while that of gabapentin moderately high. The silicone-based gel may also have one or more local anesthetics, such as prilocaine and/or lidocaine.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: September 4, 2018
    Assignee: CMPD Licensing, LLC
    Inventors: Jay Richard Ray, II, Charles D. Hodge
  • Patent number: 10060853
    Abstract: A characteristic difference between first and second liquids is measured using a surface having a monolayer of a voltage sensitive chromophore that is covalently bound to the surface. The first liquid is brought into contact with the surface and it is irradiated with actinic radiation to measure a first fluorescence emission spectrum. The second liquid is also brought into contact with the surface and it is irradiated with actinic radiation to measure a second fluorescence emission spectrum. The first and second fluorescence emission spectra are compared to characterize a difference between the first and second fluids.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: August 28, 2018
    Assignee: EASTMAN KODAK COMPANY
    Inventors: Allan Wexler, Steven C. Switalski, Grace Ann Bennett, Kimberly S. Lindner
  • Patent number: 10058865
    Abstract: A microfluidic device can comprise a plurality of interconnected microfluidic elements. A plurality of actuators can be positioned abutting, immediately adjacent to, and/or attached to deformable surfaces of the microfluidic elements. The actuators can be selectively actuated and de-actuated to create directed flows of a fluidic medium in the microfluidic (or nanofluidic) device. Further, the actuators can be selectively actuated and de-actuated to create localized flows of a fluidic medium in the microfluidic device to move reagents and/or micro-objects in the microfluidic device.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: August 28, 2018
    Assignee: Berkeley Lights, Inc.
    Inventors: Keith J. Breinlinger, Andrew W. McFarland, J. Tanner Nevill
  • Patent number: 10051988
    Abstract: A beverage making machine may employ a mixing chamber to mix a beverage medium with a precursor liquid, such as carbonated water. The mixing chamber may have a precursor liquid inlet coupled to a precursor liquid supply, a beverage medium chamber to receive a beverage medium into the beverage medium chamber, and a dispense outlet from which beverage medium and precursor liquid are dispensed, e.g., into a user's cup. The beverage medium chamber may include a chamber inlet coupled to the precursor liquid inlet, e.g., so precursor liquid can enter the chamber when a pressure is low in the beverage medium chamber, and a chamber outlet downstream of the chamber inlet that is coupled to the dispense outlet, e.g., so that beverage medium can exit the chamber.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: August 21, 2018
    Assignee: Bedford Systems LLC
    Inventors: Jeremy B. Gordon, Charles Evan O'Neill, Miles Hember, Trevor Beckett, Thomas Paul Dutremble, Gwynn Masada
  • Patent number: 10054544
    Abstract: A characteristic of a liquid is measured by providing a surface having a monolayer of a voltage sensitive chromophore that is covalently bound to the surface. The liquid is brought into contact with the surface and it is irradiated with actinic radiation to measure a first fluorescence emission spectrum. A solution of the voltage sensitive chromophore dissolved in a sample of the liquid is also irradiated with actinic radiation and a second fluorescence emission spectrum is measured. The first and second fluorescence emission spectra are compared to determine the characteristic of the liquid.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: August 21, 2018
    Assignee: EASTMAN KODAK COMPANY
    Inventors: Allan Wexler, Steven C. Switalski, Grace Ann Bennett, Kimberly S. Lindner
  • Patent number: 10052428
    Abstract: Methods and systems for removing leukocytes from a biological fluid are disclosed. The methods and systems include a device that has a magnetic substrate coated with one or more polymeric materials that have an adhesion or adsorption affinity for leukocytes.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 21, 2018
    Assignee: FENWAL, INC.
    Inventors: Yoshikazu Mizobuchi, Bruce Perry
  • Patent number: 10031128
    Abstract: A screening method evaluates influence of a cytotoxic factor on lymphoid cells. The method includes administering or irradiating lymphoid cells with the cytotoxic factor that injures the lymphoid cells; incubating the lymphoid cells to which the cytotoxic factor is administered or irradiated for a selected time; measuring a cell size of the lymphoid cells after the incubation; and determining influence of the cytotoxic factor on the lymphoid cells based on a change of the cell size. According to this method, influence of radiation or a drug, or efficacy of radiation, a radiation-protecting agent, an antioxidant, a radiation-sensitizing agent, a drug, or ultraviolet rays can be evaluated economically and objectively in a short period of time.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: July 24, 2018
    Assignee: NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY
    Inventors: Emiko Sekine, Takashi Shimokawa, Megumi Ueno, Etsuko Nakamura, Miyako Nakawatari, Takeshi Murakami, Takashi Imai, Kazunori Anzai, Kenichiro Matsumoto, Ikuo Nakanishi
  • Patent number: 10023842
    Abstract: This disclosure relates to endothelial or endothelial like cells cultured from fibroblasts exposed to transcription factor ETV2. In certain embodiments, the disclosure relates to methods of producing endothelial or endothelial like cells comprising exposing fibroblasts with ETV2 under conditions such that the fibroblasts are modified to form a pool of cells expressing increased levels of endothelium surface markers compared to the fibroblasts. In certain embodiments, the disclosure relates to using endothelial like cells reported herein for the treatment of vascular, cardiac, and wound healing indications.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: July 17, 2018
    Assignees: Emory University, The Board of Trustees of the University of Illinois
    Inventors: Young-Sup Yoon, JiWoong Han, Sang Ho Lee, Changwon Park
  • Patent number: 10022659
    Abstract: A device for isolating periphery circulating tumor cells or rare cells includes a metal filter having depressions that can capture periphery circulating tumor cells or rare cells that are in a body fluid, and pores that are formed at the depressions and that can pass therethrough body fluid cells other than periphery circulating tumor cells or rare cells.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: July 17, 2018
    Assignees: AICHI PREFECTURE, OPTNICS PRECISION CO., LTD.
    Inventors: Hayao Nakanishi, Seiji Ito, Seichin Kinuta, Yoshiyuki Ichinosawa, Akiko Yusa, Hiroyuki Honda, Mina Okochi
  • Patent number: 10018564
    Abstract: This invention relates to a method that allows for the differentiation of isolates of commonly encountered bacteria that contain specific antibiotic-resistance genes from similar isolates that do not harbor the gene. More particularly, the invention relates to a method that utilizes an automated rapid platform system that employs intrinsic fluorescence, optical data analysis, and artificial intelligence methods to analyze multi-dimensional optical characteristics of bacterial strains.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: July 10, 2018
    Assignee: POCARED DIAGNOSTICS LTD.
    Inventors: Jonathan Gurfinkel, Gal Ingber
  • Patent number: 10012638
    Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: July 3, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Mark Dayel, Samartha Anekal, Elizabeth A. Holmes
  • Patent number: 10006072
    Abstract: The present invention relates to a method for measuring the effect of a force on a film. In particular, the present invention relates to a method for measuring the effect of a mechanical, hydrodynamic or physical force, for example, on the integrity of a film, for example a film made of microorganisms, foodstuffs and/or chemical substances. The present invention is especially applicable to the fields of biology, chemistry, biotechnology and food processing.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: June 26, 2018
    Assignee: BIOFILM CONTROL
    Inventors: Thierry Bernardi, Pascal Mayer, Jerome Groelly
  • Patent number: 10006863
    Abstract: One aspect provides a system, including: a sensor adjustment component having: a memory device having adjustment information stored therein; a light engine capable of producing a signal detectable by a light detector of an optical sensor to be adjusted; and one or more processors; where the one or more processors are configured to execute program instructions to operate the light engine to produce a predetermined light pattern detectable by the light detector of the optical sensor to be adjusted; where the predetermined signal pattern comprises the adjustment information; and where the adjustment information configures said light detector that receives said predetermined signal pattern carrying the adjustment information. Other aspects are disclosed.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: June 26, 2018
    Assignee: HACH COMPANY
    Inventors: David T. Crook, Areef A. Moin
  • Patent number: 9994815
    Abstract: A method for in vitro obtaining human retinal progenitors, includes the steps of (i) placing an adherent culture of human pluripotent stem cells in a pro-neural medium; and (ii) maintaining this culture in the pro-neural medium until the appearance of pigmented cells and/or of neuroepithelial-like structures. Additional steps can be performed to obtain RPE cells and/or precursors of the neural retina.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: June 12, 2018
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Sacha Reichman, Olivier Goureau, José-Alain Sahel
  • Patent number: 9995757
    Abstract: The disclosure provides methods, kits, and devices for determining an amount of hemoglobin S and/or an amount of total hemoglobin, and optionally, expressing the amount of hemoglobin S as a percentage. Devices of the disclosure may be used as point-of-care diagnostic systems accessible for use to a layperson, i.e., an individual with minimal or no medical training or expertise.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: June 12, 2018
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Mark J. Rice, Lindsay Bazydlo, Timothy E. Morey
  • Patent number: 9994894
    Abstract: The invention relates to a novel method for the enzymatic marking of nucleic acid chains (target sequences) by means of nucleotide conjugates. Said nucleotide conjugates are able, under reaction conditions, to specifically bind to the target sequence and integrate into the complementary growing strand by means of a polymerase. The nucleic acid chains marked by such conjugates can be bound to the solid phase. The marking can be carried out parallel to the enzymatic amplification of target sequences.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: June 12, 2018
    Assignee: AGCT GMBH
    Inventors: Dmitry Cherkasov, Claus Becker, Norbert Basler, Andreas Muller-Hermann, Petra Van Husen
  • Patent number: 9989518
    Abstract: This invention relates to a method for measuring autophagy in cells, comprising using, as a probe reagent, a single fluorescent protein, to measure a change in fluorescence properties of the fluorescent probe reagent depending on pH changes associated with autophagy, thereby determining the presence or activity of autophagy, wherein the single fluorescent protein is resistant to degrading enzyme activity in the lysosome or vacuole of the cell, it is not denatured or inactivated under acidic to neutral pH environment, and it is capable of changing excitation spectra or fluorescence spectra when located under the environments of acidic region and neutral region.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: June 5, 2018
    Assignee: Japan Science and Technology Agency
    Inventors: Atsushi Miyawaki, Hiroyuki Katayama
  • Patent number: 9977025
    Abstract: Finding biologically relevant cancer markers is key to developing an effective treatment. Once specific antigens have been identified that are present on the cell population responsible for propagating tumors, T cells can be genetically altered to target these antigens and then used for personalized T cell therapy. A method to identify and select peptide antigens that effectively associate with and are presented by host HLA surface molecules originating from tumor cells responsible for the persistence and propagation of a cancer has been developed. The system of using these data to produce T cells engineered to express T cell receptors recognizing the peptide antigens is used in the production of a personalized adoptive T cell therapy for cancer that eliminates the cells capable of tumor propagation and cancer progression. The system is especially useful in the production of cancer treatments to achieve complete durable remission of cancers of epithelial origin.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: May 22, 2018
    Assignee: Verik Bio, Inc.
    Inventors: Nancy L. Parenteau, Joseph C. Laning, Janet H. Young
  • Patent number: 9977004
    Abstract: Systems and methods are provided for measuring the amount of cationic organic water treatment additives in water systems. Disclosed systems and methods monitor, analyze and control the amounts of cationic organic water treatment additive supplied to the water. Disclosed systems and methods may include various dyes and surfactants for facilitating the monitoring and control of the cationic organic water treatment additives.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: May 22, 2018
    Assignee: CHEMTREAT, INC.
    Inventors: John Richardson, Douglas McIlwaine, Benjamin Niemaseck
  • Patent number: 9970947
    Abstract: Provided herein is a fluorescent probe compound of formula (I): as well as methods of using said compound.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: May 15, 2018
    Assignee: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
    Inventors: John J. Lemasters, Andaleb I. Kholmukhamedov, Christopher Lindsey, Craig C. Beeson
  • Patent number: 9970908
    Abstract: A gradient liquid feed device allows reduction in size of a high performance liquid chromatography type sample analyzer. The gradient liquid feed device includes a plurality of carrier liquid reservoir tanks configured to store carrier liquids of mutually different compositions, a plurality of single plunger pumps capable of drawing and discharging the carrier liquid from the plurality of carrier liquid reservoir tanks, a mixer configured to mix the carrier liquids discharged from the plurality of liquid feed pumps and feed the mixed carrier liquid, and a pulse damper in communication with the mixer and configured to absorb pulsation that may occur during liquid feeding. The single plunger pumps have a function for variably setting a length of stroke for drawing and discharging the carrier liquid and a function for variably setting a ratio between the carrier liquid drawing time and the carrier liquid discharge time.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: May 15, 2018
    Assignee: Sekisui Medical Co., Ltd.
    Inventors: Takuya Yotani, Hiroaki Taira, Takayuki Oka, Hideki Muraki
  • Patent number: 9970919
    Abstract: The present invention concerns a method of estimating and optionally controlling the microbiological state in a process stream of an industrial process by measuring the concentration of dissolved oxygen or the rH value, or both, in said stream, the method including continuous or periodic sampling and online measurement. The invention also concerns a device suitable for use in implementing said method.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: May 15, 2018
    Assignee: KEMIRA OYJ
    Inventors: Pekka Ilmola, Kaj Jansson, Iiris Joensuu, Marjatta Piironen
  • Patent number: 9958432
    Abstract: The invention relates to systems and methods for studying patient cancer samples in cis-co-culture with stromal cells from the same patient. For example, the invention provide systems and methods for testing therapeutic agents in vitro in an environment that simulates an in vivo environment to identify agents that are therapeutically effective for the patient.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: May 1, 2018
    Assignee: LYNX BIOSCIENCES, INC.
    Inventors: Chorom Pak, Edmond Wai Keung Young, Natalie Callander, David James Beebe, Shigeki Miyamoto
  • Patent number: 9944951
    Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: April 17, 2018
    Assignees: Board of Regents, The University of Texas System, The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Lin Ji, John Dorrance Minna, Jack Roth, Michael Lerman
  • Patent number: 9938524
    Abstract: The invention provides novel methods and materials for genetic and genomic analysis using single or multiplex isolation of protein-associated nucleic acids, including transposase-assisted chromatin immunoprecipitation (TAM-ChIP) and antibody-oligonucleotide proximity ligation. These methods comprise tagging and isolating chromatin or other protein-associated nucleic acids and using antibody-oligonucleotide complexes that recognize the proteins associated with such nucleic acids.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: April 10, 2018
    Assignee: Active Motif, Inc.
    Inventors: Joseph Fernandez, Mary Anne Jelinek, Brian Stanley Egan
  • Patent number: 9933413
    Abstract: A method of assaying metastasis can include: providing a device of one of the embodiments; introducing the at least one cancer cell into the at least one internal chamber or at least one fluid channel; and studying metastasis of the at least one cancer cell. Optionally: introducing cancer cells into a first internal chamber; detecting escape of the cancer cell from the first internal chamber into the fluid channel; detecting migration of the cancer cell through the fluid channel; detecting adhesion of the cancer cell to a coating on the fluid channel; detecting invasion of the cancer cell into a second internal chamber from the fluid channel; or visualizing metastasis of the cancer cell with a visualization device.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: April 3, 2018
    Assignee: CFD Research Corporation
    Inventors: Balabhaskar Prabhakarpandian, Kapil Pant
  • Patent number: 9910033
    Abstract: The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: March 6, 2018
    Assignee: Centogene AG
    Inventors: Arndt Rolfs, Hermann Mascher
  • Patent number: 9902940
    Abstract: A model blood brain barrier obtained from hPSCs is disclosed.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: February 27, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Eric V. Shusta, Samira Azarin, Sean Palecek, Ethan Lippmann
  • Patent number: 9898628
    Abstract: In an approach to managing a quick response code branding device and management of a quick response code branding device, one or more computer processors receive one or more quick response code configuration parameters. The one or more computer processors determine one or more program instructions corresponding to the one or more quick response code configuration parameters based on one or more task-specific factors. The one or more computer processors send the one or more program instructions to a quick response code branding device. The one or more computer processors receive quick response code branding device status data. The one or more computer processors determine whether the quick response code branding device status data meets the one or more quick response code configuration parameters.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: February 20, 2018
    Assignee: International Business Machines Corporation
    Inventors: Pasquale A. Catalano, Andrew G. Crimmins, Arkadiy O. Tsfasman, John S. Werner
  • Patent number: 9898629
    Abstract: In an approach to managing a quick response code branding device and management of a quick response code branding device, one or more computer processors receive one or more quick response code configuration parameters. The one or more computer processors determine one or more program instructions corresponding to the one or more quick response code configuration parameters based on one or more task-specific factors. The one or more computer processors send the one or more program instructions to a quick response code branding device. The one or more computer processors receive quick response code branding device status data. The one or more computer processors determine whether the quick response code branding device status data meets the one or more quick response code configuration parameters.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: February 20, 2018
    Assignee: International Business Machines Corporation
    Inventors: Pasquale A. Catalano, Andrew G. Crimmins, Arkadiy O. Tsfasman, John S. Werner
  • Patent number: 9878329
    Abstract: A self-contained sample processing cartridge, is disclosed. The sample processing cartridge includes a first member that includes a receiver to receive a sample specimen slide. The cartridge may also include a second member that closes on the first member to form a chamber inside the cartridge. The sample specimen slide forms a surface of the chamber. Placing the slide in the cartridge effectively completes the chamber of the cartridge. In one embodiment, the receiver of the first member includes an open region adjacent which the specimen slide is received. The second member includes a plurality of fluid inputs and at least one fluid output. The plurality of fluid inputs couples to the chamber by a plurality of channels respectively therebetween. In one embodiment, at least one of the plurality of channels may include a reagent reservoir and at least one of the plurality of channels includes a dissolvable blocking reservoir.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: January 30, 2018
    Assignee: SYFR, Inc.
    Inventors: Shazi S Iqbal, Michael Mayo, Paul Parks, Alexander Greis
  • Patent number: 9868786
    Abstract: Provided are methods for suppressing IgE and IgG-mediated allergic reactions through monoclonal antibody applications. More specifically, methods are herein provided for safe induction of rapid desensitization. Specific embodiments are herein provided for suppressing allergic reactions in a subject, including specific methods of providing a monoclonal antibody selected from the group consisting of anti-Fc?RIa and anti-Fc?RIIb / RIII; administering the antibody to a subject at a dose that is lower than the level required to induce shock; and administering sequentially escalating doses of the monoclonal antibody so as to induce rapid desensitization to an allergen, thereby suppressing allergic reaction in the subject.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: January 16, 2018
    Assignees: University of Cincinnati, Children's Hospital Medical Center, U.S. Department of Veterans Affairs, Medizinische Universität Wien
    Inventors: Fred D. Finkelman, Marat V. Khodoun, Durga Krishnamurthy, Richard T. Strait, Zeynep (Yesim) Kucuk
  • Patent number: 9867861
    Abstract: The disclosure provides a method for treating, reducing, alleviating or preventing metabolic syndrome or metabolic malady, comprising administering a composition comprising a cell line callus culture of fruit cells grown in vitro. Further provided are fruit cells prepared according to a large scale process. The cell line callus culture of grape berry cells manufactured according to the process includes resveratrol in an amount of at least 1000 mg/kg powder.
    Type: Grant
    Filed: December 24, 2013
    Date of Patent: January 16, 2018
    Assignee: BIO HARVEST LTD.
    Inventors: Yoheved Hagay, Michal Abargel, Malkit Azachi, Yoav Roth, Rivka Yatuv
  • Patent number: 9870894
    Abstract: The present invention provides an embedding resin composition for electron microscopy having satisfactory performance as an embedding medium, including embedding performance and sectioning quality, and exhibiting excellent antistatic performance; and a method for observing a sample with an electron microscope using the composition. The embedding resin composition for electron microscopy of the present invention having antistatic performance comprises an ionic liquid and an embedding medium comprising an epoxy-based resin, a methacrylate resin or an unsaturated polyester resin. Preferably, the ionic liquid comprising a quaternary ammonium compound based on the formula (I): and an anion selected from the group consisting of BF4?, PF6?, (CF3SO2)2N?, a halide ion, a conjugate base of carboxylic acid, a conjugate base of sulfonic acid and a conjugate base of an inorganic acid.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: January 16, 2018
    Assignee: KURUME UNIVERSITY
    Inventors: Keisuke Ohta, Toshiyuki Kiryu
  • Patent number: 9865054
    Abstract: An evaluation method of a spheroid comprises specifying a spheroid region taken up by the spheroid out of the image including the spheroid and a surrounding region thereof, obtaining an average value of an optical density of the spheroid and a magnitude of a variation of the optical density in the spheroid from an image density of the spheroid region, obtaining a circularity of the spheroid from a contour of the spheroid region, obtaining a sharpness of the spheroid from the image densities of the spheroid and the surrounding region thereof, and obtaining the collapse degree of the spheroid by substituting the average value of the optical density, the magnitude of the variation of the optical density, the circularity and the sharpness into a predetermined operational expression.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: January 9, 2018
    Assignee: SCREEN HOLDINGS CO., LTD.
    Inventor: Jiro Tsumura