Tobacco Cell Or Cell Line, Per Se Patents (Class 435/414)
  • Patent number: 8940967
    Abstract: A novel soybean variety, designated XB02W13 is provided. Also provided are the seeds of soybean variety XB02W13, cells from soybean variety XB02W13, plants of soybean XB02W13, and plant parts of soybean variety XB02W13. Methods provided include producing a soybean plant by crossing soybean variety XB02W13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB02W13, methods for producing other soybean varieties or plant parts derived from soybean variety XB02W13, and methods of characterizing soybean variety XB02W13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB02W13 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: January 27, 2015
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Nadejda N. Krasheninnik
  • Patent number: 8940969
    Abstract: A novel soybean variety, designated XB22T13 is provided. Also provided are the seeds of soybean variety XB22T13, cells from soybean variety XB22T13, plants of soybean XB22T13, and plant parts of soybean variety XB22T13. Methods provided include producing a soybean plant by crossing soybean variety XB22T13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB22T13, methods for producing other soybean varieties or plant parts derived from soybean variety XB22T13, and methods of characterizing soybean variety XB22T13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB22T13 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: January 27, 2015
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Bradley R. Hedges, Kari Greason, Paul A. Stephens
  • Patent number: 8940970
    Abstract: A novel soybean variety, designated XB33U13 is provided. Also provided are the seeds of soybean variety XB33U13, cells from soybean variety XB33U13, plants of soybean XB33U13, and plant parts of soybean variety XB33U13. Methods provided include producing a soybean plant by crossing soybean variety XB33U13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB33U13, methods for producing other soybean varieties or plant parts derived from soybean variety XB33U13, and methods of characterizing soybean variety XB33U13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB33U13 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: January 27, 2015
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Thomas C. Corbin
  • Publication number: 20150026845
    Abstract: Compositions and methods for modifying the production levels of alkaloids in plants are provided. Alkaloid production can be genetically controlled by modulating the transcriptional activation of PMT genes mediated by members of the ERF family and/or Myc family of transcription factors. Novel nucleotide sequences encoding the Myc family of transciption factors are also provided.
    Type: Application
    Filed: June 23, 2014
    Publication date: January 22, 2015
    Inventors: Michael Paul Timko, Paul J. Rushton, Sheng-Cheng Han, Hongbo Zhang, Marta Tatiana Bokowiec
  • Publication number: 20150025124
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity).
    Type: Application
    Filed: September 30, 2014
    Publication date: January 22, 2015
    Inventors: RAFAEL HERRMANN, MICHAEL LASSNER, ALBERT L. LU, MARK EDWARD NELSON, JAMES KEVIN PRESNAIL, JANET A. RICE
  • Patent number: 8937221
    Abstract: A novel soybean variety, designated XRP35010 is provided. Also provided are the seeds of soybean variety XRP35010, cells from soybean variety XRP35010, plants of soybean XRP35010, and plant parts of soybean variety XRP35010. Methods provided include producing a soybean plant by crossing soybean variety XRP35010 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XRP35010, methods for producing other soybean varieties or plant parts derived from soybean variety XRP35010, and methods of characterizing soybean variety XRP35010. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XRP35010 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: January 20, 2015
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Catlynn G. Salois
  • Patent number: 8935880
    Abstract: Methods for manipulating yield and generation time of plants, especially short day plants such as soybean are provided. The methods comprise manipulating external signals such as long day conditions, short day conditions, growth medium, and nutrient supply.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: January 20, 2015
    Assignee: Monsanto Technology LLC
    Inventors: Daniel J. Ovadya, Bala Karunanandaa, Karen Gabbert, Qin Zeng
  • Publication number: 20150020241
    Abstract: The present invention provides non-coding regulatory element polynucleotide molecules isolated from the S-adenosyl methionine synthetase (SAMS3) gene of Arabidopsis thaliana and useful for expressing transgenes in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the Arabidopsis thaliana regulatory polynucleotide sequences, and methods for preparing and using the same.
    Type: Application
    Filed: June 6, 2014
    Publication date: January 15, 2015
    Inventors: Wei Wu, Qi Wang, Michael Edgerton, Kim Beazley, Jill Deikman, Michael W. Petersen, Bei Zhang
  • Patent number: 8933305
    Abstract: A novel soybean variety, designated XRP32008 is provided. Also provided are the seeds of soybean variety XRP32008, cells from soybean variety XRP32008, plants of soybean XRP32008, and plant parts of soybean variety XRP32008. Methods provided include producing a soybean plant by crossing soybean variety XRP32008 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XRP32008, methods for producing other soybean varieties or plant parts derived from soybean variety XRP32008, and methods of characterizing soybean variety XRP32008. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XRP32008 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: January 13, 2015
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Donald Kyle, Jessie Lynn Alt
  • Patent number: 8933304
    Abstract: A novel soybean variety, designated XB02F13 is provided. Also provided are the seeds of soybean variety XB02F13, cells from soybean variety XB02F13, plants of soybean XB02F13, and plant parts of soybean variety XB02F13. Methods provided include producing a soybean plant by crossing soybean variety XB02F13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB02F13, methods for producing other soybean varieties or plant parts derived from soybean variety XB02F13, and methods of characterizing soybean variety XB02F13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB02F13 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: January 13, 2015
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Nadejda N. Krasheninnik, Martin A. Fabrizius, Michael T. Roach
  • Patent number: 8933297
    Abstract: The invention provides Nicotiana benthamiana mutant plants which are incapable of forming xylosyl-structures on glycoproteins. In addition, the invention provides methods for the production of heterologous glycoproteins in said mutant plants.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: January 13, 2015
    Assignee: Icon Genetics GmbH
    Inventors: Koen Weterings, Gerben Van Eldik
  • Publication number: 20150013031
    Abstract: The present invention relates to methods and compositions for improving the efficiency of Agrobacterium- and Rhizobium-mediated plant cell transformation by use of additional transformation enhancer sequences, such as overdrive or TSS sequences, operably linked to a T-DNA border sequence on a recombinant construct that comprises T-DNA.
    Type: Application
    Filed: June 3, 2014
    Publication date: January 8, 2015
    Inventors: Larry A. Gilbertson, Xudong Ye
  • Patent number: 8927814
    Abstract: A novel soybean variety, designated XBP52005 is provided. Also provided are the seeds of soybean variety XBP52005, cells from soybean variety XBP52005, plants of soybean XBP52005, and plant parts of soybean variety XBP52005. Methods provided include producing a soybean plant by crossing soybean variety XBP52005 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XBP52005, methods for producing other soybean varieties or plant parts derived from soybean variety XBP52005, and methods of characterizing soybean variety XBP52005. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XBP52005 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: January 6, 2015
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Mark J. Hood
  • Patent number: 8927815
    Abstract: A novel soybean variety, designated XB01Z13 is provided. Also provided are the seeds of soybean variety XB01Z13, cells from soybean variety XB01Z13, plants of soybean XB01Z13, and plant parts of soybean variety XB01Z13. Methods provided include producing a soybean plant by crossing soybean variety XB01Z13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB01Z13, methods for producing other soybean varieties or plant parts derived from soybean variety XB01Z13, and methods of characterizing soybean variety XB01Z13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB01Z13 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: January 6, 2015
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Nadejda N. Krasheninnik
  • Publication number: 20150007363
    Abstract: The subject invention pertains to novel mutant polynucleotide molecules that encode enzymes that have increased heat stability. These polynucleotides, when expressed in plants, result in increased yield in plants grown under conditions of heat stress. The polynucleotide molecules of the subject invention encode maize endosperm ADP glucose pyrophosphorylase (AGP) and soluble starch synthase (SSS) enzyme activities. Plants and plant tissue bred to contain, or transformed with, the mutant polynucleotides, and expressing the polypeptides encoded by the polynucleotides, are also contemplated by the present invention. The subject invention also concerns methods for isolating polynucleotides and polypeptides contemplated within the scope of the invention. Methods for increasing yield in plants grown under conditions of heat stress are also provided.
    Type: Application
    Filed: July 1, 2014
    Publication date: January 1, 2015
    Inventors: L. CURTIS HANNAH, THOMAS W. GREENE
  • Patent number: 8921667
    Abstract: A novel soybean variety, designated XB01Y13 is provided. Also provided are the seeds of soybean variety XB01Y13, cells from soybean variety XB01Y13, plants of soybean XB01Y13, and plant parts of soybean variety XB01Y13. Methods provided include producing a soybean plant by crossing soybean variety XB01Y13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB01Y13, methods for producing other soybean varieties or plant parts derived from soybean variety XB01Y13, and methods of characterizing soybean variety XB01Y13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB01Y13 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: December 30, 2014
    Assignee: Pioneeri Hi-Bred International, Inc.
    Inventor: Nadejda N. Krasheninnik
  • Patent number: 8921666
    Abstract: A novel soybean variety, designated XB40S13 is provided. Also provided are the seeds of soybean variety XB40S13, cells from soybean variety XB40S13, plants of soybean XB40S13, and plant parts of soybean variety XB40S13. Methods provided include producing a soybean plant by crossing soybean variety XB40S13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB40S13, methods for producing other soybean varieties or plant parts derived from soybean variety XB40S13, and methods of characterizing soybean variety XB40S13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB40S13 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: December 30, 2014
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Thomas C. Corbin, Leon G. Streit
  • Patent number: 8921665
    Abstract: A novel soybean variety, designated XB009M13 is provided. Also provided are the seeds of soybean variety XB009M13, cells from soybean variety XB009M13, plants of soybean XB009M13, and plant parts of soybean variety XB009M13. Methods provided include producing a soybean plant by crossing soybean variety XB009M13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB009M13, methods for producing other soybean varieties or plant parts derived from soybean variety XB009M13, and methods of characterizing soybean variety XB009M13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB009M13 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: December 30, 2014
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Nadejda N. Krasheninnik, John Michael Eidenshink
  • Publication number: 20140352706
    Abstract: The present invention relates to a mutant, non-naturally occurring or transgenic plant cell comprising: (i) at least one polynucleotide comprising, consisting or consisting essentially of a sequence encoding an isopropylmalate synthase and having at least 60% sequence identity to SEQ ID NO:1 or SEQ ID NO:10 or SEQ ID NO: 12 or SEQ ID NO:14; or (ii) a polypeptide encoded by said polynucleotide(s); or (iii) a polypeptide having at least 60% sequence identity to SEQ ID NO:2 or SEQ ID NO:11 or SEQ ID NO:13 or SEQ ID NO:15; or (iv) a construct, vector or expression vector comprising said polynucleotide sequence(s), optionally wherein said construct, vector or expression vector additionally comprises a promoter comprising, consisting or consisting essentially of the sequence set forth in SEQ ID NO:8 or a variant thereof with at least about 60% identity thereto or a trichome promoter.
    Type: Application
    Filed: August 31, 2012
    Publication date: December 4, 2014
    Applicant: PHILIP MORRIS PRODUCTS S.A.
    Inventors: Nicholas Bakaher, Gregor Nicholas Bindler, Michel Philippe Blanc, Simon Goepfert, Florian Martin
  • Publication number: 20140356347
    Abstract: The present disclosure provides novel variants of enzymes exhibiting serine protease activity; nucleic acid molecules encoding said proteases, vectors, host cells containing the nucleic acids and methods for preparation and producing such enzymes; compositions and complexes comprising at least one of the proteases; and methods for using such enzymes as a part of an immunoprotease, in particular for the treatment of cancer.
    Type: Application
    Filed: September 21, 2012
    Publication date: December 4, 2014
    Inventors: Stefan Barth, Sonja Schiffer, Grit Hehmann-Titt
  • Patent number: 8895814
    Abstract: A novel soybean variety, designated XB22Z13 is provided. Also provided are the seeds of soybean variety XB22Z13, cells from soybean variety XB22Z13, plants of soybean XB22Z13, and plant parts of soybean variety XB22Z13. Methods provided include producing a soybean plant by crossing soybean variety XB22Z13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB22Z13, methods for producing other soybean varieties or plant parts derived from soybean variety XB22Z13, and methods of characterizing soybean variety XB22Z13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB22Z13 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: November 25, 2014
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Jessie Lynn Alt, Jordan Spear, Paul A. Stephens
  • Patent number: 8895815
    Abstract: A novel soybean variety, designated XB38AT13 is provided. Also provided are the seeds of soybean variety XB38AT13, cells from soybean variety XB38AT13, plants of soybean XB38AT13, and plant parts of soybean variety XB38AT13. Methods provided include producing a soybean plant by crossing soybean variety XB38AT13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB38AT13, methods for producing other soybean varieties or plant parts derived from soybean variety XB38AT13, and methods of characterizing soybean variety XB38AT13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB38AT13 are further provided.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: November 25, 2014
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Les Charles Kuhlman, Thomas C. Corbin
  • Publication number: 20140342404
    Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
    Type: Application
    Filed: April 10, 2013
    Publication date: November 20, 2014
    Applicant: GENENTECH, INC.
    Inventor: Leonard G. PRESTA
  • Publication number: 20140343131
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lygus genus, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides from specific polypeptide families as disclosed herein, and further provides target polynucleotides set forth in SEQ ID NOS:1-21 or active variants thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Lygus Hesperus.
    Type: Application
    Filed: August 8, 2014
    Publication date: November 20, 2014
    Inventors: RAFAEL HERRMANN, Michael Lassner, Albert Laurence Lu, Mark Edward Nelson, James Kevin Presnail, Janet Ann Rice
  • Publication number: 20140342453
    Abstract: A nucleotide construct comprising a nucleotide sequence that forms a stem and a loop, wherein the loop comprises a nucleotide sequence that modulates expression of a target, wherein the stem comprises a nucleotide sequence that modulates expression of a target, and wherein the target modulated by the nucleotide sequence in the loop and the target modulated by the nucleotide sequence in the stem may be the same or different. Vectors, methods of regulating target expression, methods of providing a cell, and methods of treating conditions comprising the nucleotide sequence are also disclosed.
    Type: Application
    Filed: August 5, 2014
    Publication date: November 20, 2014
    Inventors: John Shanklin, Tam Huu Nguyen
  • Publication number: 20140342450
    Abstract: Provided are antibodies including human antibodies and antigen-binding portions thereof that specifically bind to CCR2, preferably human CCR2, and that may inhibit CCR2. The present antibodies may bind to the first and/or second extracellular loops of CCR2. Isolated heavy and light chains derived from the antibodies and nucleic acid molecules encoding the antibodies and chains are provided. Methods of making and using the anti-CCR2 antibodies or antigen-binding portions, and compositions comprising these antibodies or antigen-binding portions, including compositions for diagnosis and treatment, are provided. Also provided are gene therapy methods using nucleic acid molecules encoding the heavy and/or light chains that comprise the human anti-CCR2 antibodies or antigen-binding portions thereof.
    Type: Application
    Filed: April 3, 2014
    Publication date: November 20, 2014
    Applicants: Amgen Fremont Inc., Pfizer Inc.
    Inventors: Ronald P. Gladue, Bradley T. Keller, Shinji Ogawa, Arvind Rajpal, Laurie A. Tylaska, Shelley Sims Belouski, Larry L. Green, Meina L. Liang
  • Patent number: 8889956
    Abstract: A novel soybean variety, designated XB79B13 is provided. Also provided are the seeds of soybean variety XB79B13, cells from soybean variety XB79B13, plants of soybean XB79B13, and plant parts of soybean variety XB79B13. Methods provided include producing a soybean plant by crossing soybean variety XB79B13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB79B13, methods for producing other soybean varieties or plant parts derived from soybean variety XB79B13, and methods of characterizing soybean variety XB79B13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB79B13 are further provided.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: November 18, 2014
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Luis C. Prado
  • Patent number: 8884118
    Abstract: A novel soybean variety, designated XB86G13 is provided. Also provided are the seeds of soybean variety XB86G13, cells from soybean variety XB86G13, plants of soybean XB86G13, and plant parts of soybean variety XB86G13. Methods provided include producing a soybean plant by crossing soybean variety XB86G13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB86G13, methods for producing other soybean varieties or plant parts derived from soybean variety XB86G13, and methods of characterizing soybean variety XB86G13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB86G13 are further provided.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: November 11, 2014
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Luis C. Prado
  • Publication number: 20140322218
    Abstract: The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
    Type: Application
    Filed: January 27, 2014
    Publication date: October 30, 2014
    Applicant: AMGEN RESEARCH (MUNICH) GMBH
    Inventors: Shouhua Xiao, Zheng Pan, Dineli Wickramasinghe, Shawn Jeffries, Chadwick T. King, Brian Mingtung Chan, Peter Kufer, Ralf Lutterbüse, Tobias Raum, Patrick Hoffmann, Doris Rau, Roman Kischel, Bryan Lemon, Holger Wesche
  • Publication number: 20140322221
    Abstract: The present application describes engineered antibodies, with three or more functional antigen binding sites, and uses, such as therapeutic applications, for such engineered antibodies.
    Type: Application
    Filed: March 28, 2014
    Publication date: October 30, 2014
    Applicant: Genentech, Inc.
    Inventors: Kathy L. MILLER, Leonard G. PRESTA
  • Publication number: 20140322812
    Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
    Type: Application
    Filed: April 24, 2014
    Publication date: October 30, 2014
    Applicant: Intrexon Corporation
    Inventors: Subba Reddy PALLI, Mohan Basavaraju KUMAR
  • Publication number: 20140311502
    Abstract: A tobacco plant comprising at least one mutation in a HMA gene, wherein the non-mutated HMA gene comprises the nucleotide sequence. of SEQ ID NO: 1 or a homolog sequence, wherein the mutation causes a substitution or a deletion or an insertion of at least one amino acid in the polypeptide encoded by the nucleotide sequence and wherein the mutation reduces the heavy metal uptake by the leaves of the plant by at least 30% in relation to the heavy metal uptake of plants comprising SEQ ID NO:1 or the homolog.
    Type: Application
    Filed: September 28, 2011
    Publication date: October 23, 2014
    Applicant: Societe nationale D'Exploitation Industrielle des Tabacs et Allumettes-S.E.I.T.A.
    Inventors: Emilie Julio, Francois Dorlhac de Borne, Victor Hermand
  • Publication number: 20140308271
    Abstract: The present invention relates to antibodies or fragments thereof that bind to TL1A. More specifically, the present invention relates to an antibody or fragment thereof that binds to TL1A comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 51, and/or a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 52, and/or a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 53; and/or comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 54, and/or a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 55 and/or a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 56.
    Type: Application
    Filed: January 2, 2014
    Publication date: October 16, 2014
    Applicant: GLENMARK PHARMACEUTICALS S.A.
    Inventors: ANTOINE ATTINGER, JONATHAN ALBERT BACK, STANISLAS BLEIN, RAMI LISSILAA, DARKO SKEGRO
  • Publication number: 20140309405
    Abstract: The present invention provides a method capable of producing a natural or recombinant protein in high yield. The present invention relates to a method of producing a polypeptide, comprising culturing a cell which strongly expresses alanine aminotransferase and has a transferred DNA encoding a desired polypeptide and thereby allowing the cell to produce the polypeptide.
    Type: Application
    Filed: March 26, 2014
    Publication date: October 16, 2014
    Inventors: Hisahiro Tabuchi, Tomoya Sugiyama
  • Publication number: 20140298543
    Abstract: The invention provides compositions and methods for manipulating the exchange of water and/or carbon dioxide (CO2) through plant stomata by controlling CO2 sensor genes. The invention provides compositions and methods for enhancing or optimizing biomass accumulation in a plant. The invention provides compositions and methods for opening or closing a stomatal pore on a guard cell in the epidermis of a plant. The invention provides compositions and methods for increasing or decreasing oxygenation efficiency and/or carbon fixation in a guard cell in the epidermis of a plant by manipulating expression of a ribulose-1,5-bisphosphate carboxylase/oxygenase. The invention provides promoters for regulating expression of a nucleic acid in a plant guard cell.
    Type: Application
    Filed: March 5, 2014
    Publication date: October 2, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Julian I. SCHROEDER, Maria ISRAELSSON-NORDSTROM, Josef M. KUHN, Yingzhen YANG, Honghong HU, Aurelien BOISSON-DERNIER
  • Publication number: 20140298508
    Abstract: The present invention is directed to alpha-mannosidase sequences from plants and the use thereof, especially genomic nucleotide sequences containing the regulatory elements controlling their expression, intron and exon sequences and polynucleotide sequences coding for alpha-mannosidase enzymes. Such plants with modified alpha-mannosidase activity can be used for the production of glycoproteins having an altered saccharide composition of great benefit. The present invention also relates to the use of these alpha-mannosidase enzymes for hydrolyzing mannoses.
    Type: Application
    Filed: December 23, 2011
    Publication date: October 2, 2014
    Applicant: PHILIP MORRIS PRODUCTS S.A.
    Inventors: Nikolai Valeryevitch Ivanov, Prisca Camponini, Dionisius Florack, Karen Oishi
  • Publication number: 20140289901
    Abstract: A mutant, non-naturally occurring or transgenic plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a neoxanthin synthase and having at least 60% sequence identity to SEQ ID NO:1 or SEQ ID No. 6; (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide having at least 66% sequence identity to SEQ ID NO:2 or at least 60% sequence identity to SEQ ID No. 7; or (iv) a construct, vector or expression vector comprising the isolated polynucleotide set forth in (i), and wherein the expression or activity of the neoxanthin synthase is modulated as compared to a control or wild type plant.
    Type: Application
    Filed: October 30, 2012
    Publication date: September 25, 2014
    Inventors: Lucien Bovet, Jeremy Catinot, Joanne Schwaar
  • Publication number: 20140289904
    Abstract: Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the organism, and in one aspect, to inhibit KASII or KASIII.
    Type: Application
    Filed: March 21, 2013
    Publication date: September 25, 2014
    Applicant: DSM IP Assets B.V.
    Inventors: James G. METZ, Jerry M. Kuner, James Casey Lippmeier
  • Publication number: 20140271623
    Abstract: Antibody variants having decreased or increased ability to mediate CDC due to modifications at the C-terminus of their heavy chains are described. Methods of generating such antibodies, as well as nucleotide constructs and host cells suitable for the production of said antibodies are also described.
    Type: Application
    Filed: July 6, 2012
    Publication date: September 18, 2014
    Applicant: GENMAB A/S
    Inventors: Paul Parren, Patrick Van Berkel, Ewald T.J. Van Den Bremer
  • Publication number: 20140275487
    Abstract: The present invention relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present invention relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present invention can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.
    Type: Application
    Filed: June 21, 2012
    Publication date: September 18, 2014
    Inventors: Jan Steyaert, Els Pardon, Toon Laeremans, Brian Kobilka, Søren Rasmussen, Sébastien Granier, Roger K. Sunahara
  • Publication number: 20140275213
    Abstract: The present invention comprises methods and compositions for controlling nematode parasitism in host plant. The present invention comprises novel polynucleotides and polypeptides encoded by such polynucleotides comprising one or more nucleic acid sequences disclosed herein having a nucleotide sequence comprising any one of SEQ ID NOs: 1-142, a fragment or variant thereof, or a complement thereof, or a polypeptide sequence comprising any one of SEQ ID NOs: 143-159, a fragment or variant thereof.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicants: Pioneer Hi-Bred International, Inc., Iowa State University Research Foundation, Inc., The Curators of the University of Missouri, University of Georgia Research Foundation, Inc., North Carolina State University
    Inventors: Jun-zhi Wei, Gusui Wu, Carl R. Simmons, Thomas Baum, Eric Davis, Richard Hussey, Melissa G. Mitchum
  • Publication number: 20140274874
    Abstract: There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: AMGEN INC.
    Inventors: Randal R. KETCHEM, Jason Charles O'NEILL, Jeonghoon SUN
  • Publication number: 20140283165
    Abstract: A process for producing a reduced tobacco-specific nitrosamine (TSNA) tobacco plant comprising reducing and/or eliminating anatabine biosynthesis in wild-type tobacco plant. In addition, use of such plants for discovery of molecular markers that are closely linked with genes required for anatabine biosynthesis and for discovery of genes required for anatabine biosynthesis. In addition, a smoking composition, a smoking article and a smokeless tobacco oral delivery product contain the tobacco material.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: Altria Client Services Inc.
    Inventors: Chengalrayan Kudithipudi, Rutger Van der Hoeven, Ndjido Kane
  • Publication number: 20140259220
    Abstract: The present invention provides methods for increasing plant biomass and plant seed yield through overexpression of a PHB gene. Also provided are plants with increased biomass and seed yield comprising overexpression of a PHB gene produced by such methods. Plants described herein may be used, for example, for improved production of biofuels.
    Type: Application
    Filed: March 5, 2014
    Publication date: September 11, 2014
    Applicant: The Texas A&M University System
    Inventor: Shuhua Yuan
  • Publication number: 20140251353
    Abstract: The present disclosure provides tobacco inbred plants TN90 SRC, CMS TN90 SRC, KY14 SRC, CMS KY14 SRC, L8 SRC, NC775 SRC, CMS NC775 SRC, NC645 SRC, NC638 SRC, CMS NC638 SRC, TN86 SRC, and CMS TN86 SRC, and hybrids KY14 X L8 SRC, NC7 SRC, and NCBH129 SRC. The present disclosure also provides parts of such plants and products made from those parts. The present disclosure also includes progeny of the provided plants including hybrids.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 11, 2014
    Applicant: North Carolina State University
    Inventors: Ramsey S. Lewis, Ralph E. Dewey
  • Publication number: 20140250552
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Coleopteran plant pest or a Diabrotica plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-236 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is D. virgifera virgifera, D. barberi, D. speciosa, or D. undecimpunctata howardi.
    Type: Application
    Filed: March 8, 2013
    Publication date: September 4, 2014
    Applicants: E. I. DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL
    Inventors: Karen E. Broglie, Mani Muthalagi, Kevin Kriss, Albert L. Lu, James K. Presnail
  • Publication number: 20140246036
    Abstract: The present invention provides nucleic acids encoding transcription factors and methods of using these nucleic acids to modulate nicotine production in plants and to produce plants having modulated nicotine production.
    Type: Application
    Filed: February 27, 2014
    Publication date: September 4, 2014
    Applicant: North Carolina State University
    Inventors: Rongda Qu, Bingwu Wang
  • Patent number: 8822757
    Abstract: Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: September 2, 2014
    Assignee: National Research Council of Canada
    Inventors: Jonathan Page, Andrea T. Todd
  • Patent number: 8822773
    Abstract: A novel soybean variety, designated XB78B13 is provided. Also provided are the seeds of soybean variety XB78B13, cells from soybean variety XB78B13, plants of soybean XB78B13, and plant parts of soybean variety XB78B13. Methods provided include producing a soybean plant by crossing soybean variety XB78B13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB78B13, methods for producing other soybean varieties or plant parts derived from soybean variety XB78B13, and methods of characterizing soybean variety XB78B13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB78B13 are further provided.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: September 2, 2014
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Welcimar Goncalves da Cunha, Luis C. Prado
  • Patent number: 8822774
    Abstract: A novel soybean variety, designated XB85F13 is provided. Also provided are the seeds of soybean variety XB85F13, cells from soybean variety XB85F13, plants of soybean XB85F13, and plant parts of soybean variety XB85F13. Methods provided include producing a soybean plant by crossing soybean variety XB85F13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB85F13, methods for producing other soybean varieties or plant parts derived from soybean variety XB85F13, and methods of characterizing soybean variety XB85F13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB85F13 are further provided.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: September 2, 2014
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Luis C. Prado