Tobacco Cell Or Cell Line, Per Se Patents (Class 435/414)
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Patent number: 8624091Abstract: A novel soybean variety, designated XB04A12 is provided. Also provided are the seeds of soybean variety XB04A12, cells from soybean variety XB04A12, plants of soybean XB04A12, and plant parts of soybean variety XB04A12. Methods provided include producing a soybean plant by crossing soybean variety XB04A12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB04A12, methods for producing other soybean varieties or plant parts derived from soybean variety XB04A12, and methods of characterizing soybean variety XB04A12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB04A12 are further provided.Type: GrantFiled: March 1, 2012Date of Patent: January 7, 2014Assignee: Pioneer Hi Bred International IncInventors: Nadejda N. Krasheninnik, Martin A. Fabrizius, Michael T. Roach
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Patent number: 8624088Abstract: A novel soybean variety, designated 95R51 is provided. Also provided are the seeds of soybean variety 95R51, cells from soybean variety 95R51, plants of soybean 95R51, and plant parts of soybean variety 95R51. Methods provided include producing a soybean plant by crossing soybean variety 95R51 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 95R51, methods for producing other soybean varieties or plant parts derived from soybean variety 95R51, and methods of characterizing soybean variety 95R51. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 95R51 are further provided.Type: GrantFiled: December 19, 2011Date of Patent: January 7, 2014Assignee: Pioneer Hi Bred International IncInventors: Mark J. Hood, Jeffrey A. Thompson
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Patent number: 8624090Abstract: A novel soybean variety, designated XB48W12 is provided. Also provided are the seeds of soybean variety XB48W12, cells from soybean variety XB48W12, plants of soybean XB48W12, and plant parts of soybean variety XB48W12. Methods provided include producing a soybean plant by crossing soybean variety XB48W12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB48W12, methods for producing other soybean varieties or plant parts derived from soybean variety XB48W12, and methods of characterizing soybean variety XB48W12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB48W12 are further provided.Type: GrantFiled: March 1, 2012Date of Patent: January 7, 2014Assignee: Pioneer Hi Bred International IncInventors: Jeffrey A. Thompson, Mark J. Hood
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Publication number: 20140007305Abstract: Two genes, A622 and NBB1, can be influenced to achieve a decrease of nicotinic alkaloid levels in plants. In particular, suppression of one or both of A622 and NBB1 may be used to decrease nicotine in tobacco plants.Type: ApplicationFiled: April 8, 2011Publication date: January 2, 2014Inventors: Takashi HASHIMOTO, Akira Kato
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Publication number: 20130347146Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.Type: ApplicationFiled: June 19, 2013Publication date: December 26, 2013Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Hendrikus Antonius Cornelis Bakker, Dionisius Elisabeth Antonius Florack, Hendrik Jan Bosch
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Publication number: 20130336926Abstract: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.Type: ApplicationFiled: June 11, 2013Publication date: December 19, 2013Applicant: Amgen Inc.Inventors: John E. SIMS, Blair R. RENSHAW, Christopher GABEL, Jennifer E. TOWNE, Randal R. KETCHEM
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Publication number: 20130326727Abstract: The present invention belongs to genetic engineering technical field and discloses modified protein body tags, a system for evaluating the efficacy of the modified polypeptides, and methods for targeting proteins to protein bodies or for forming protein bodies. The present invention also discloses modified protein body tags with reduced allergenicity and methods for making and using the modified protein body tags.Type: ApplicationFiled: December 8, 2011Publication date: December 5, 2013Inventors: Lahoucine Achnine, Jill Stevenson-Paulik, Suzy M. Cocciolone, Durba Ghoshal, Jeffrey A. Brown, Libby Bernal
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Publication number: 20130315918Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.Type: ApplicationFiled: June 27, 2013Publication date: November 28, 2013Applicant: Genentech, Inc.Inventors: GERMAINE FUH, HANS-PETER GERBER, WEI-CHING LIANG, FREDERIC FELLOUSE, SACHDEV S. SIDHU, CHRISTIAN WIESMANN
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Publication number: 20130309682Abstract: Provided herein is a synthetic or isolated polynucleotide encoding a mammalian 18S rRNA that is resistant to pactamycin. The pactamycin-resistance is conferred by one or more single residue substitutions in the 18S rRNA sequence; a fragment thereof harboring said substitutions; a complementary sequence thereto; or a substantially identical sequence of the foregoing. Related systems, methods and kits are also described.Type: ApplicationFiled: May 21, 2013Publication date: November 21, 2013Inventors: Vincent P. Mauro, Luke Burman, Gerald M. Edelman
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Publication number: 20130309747Abstract: The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.Type: ApplicationFiled: December 9, 2011Publication date: November 21, 2013Inventors: Philippe Despres, Sylvie Paulous, Elodie Crublet
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Publication number: 20130295065Abstract: Nucleic acid expression constructs are provided and, more particularly, nucleic acid constructs for expression of human alpha-galactosidase in plant cells, cells expressing the nucleic acid construct, producing the human alpha-galactosidase and uses thereof.Type: ApplicationFiled: September 7, 2011Publication date: November 7, 2013Applicant: Protalix Ltd.Inventors: Avidor Shulman, Uri Hanania, Tali Kizhner, Yoseph Shaaltiel
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Patent number: 8563827Abstract: The present invention relates to the development of tobacco plants, modified through mutagenesis techniques, interspecific hybridisation followed by poliploidisation and recombinant DNA technologies, characterised by the fact of being capable of producing a very high amount of seeds and their use for the production of oil for energetic and industrial scopes, such as combustion oil, biodiesel and lubricating oil, and for animal and human alimentation.Type: GrantFiled: August 27, 2007Date of Patent: October 22, 2013Assignee: AEP-Advanced Ecopower Patents S.A.Inventor: Corrado Fogher
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Publication number: 20130276166Abstract: A method of enhancement of the 1-deoxy-D-xylulose 5-phosphate synthase (DXS) activity of plants or bacteria to increase terpenes production in cells, an enhanced DXS sequence likely to be obtained by this method, a method of enhancement of production of terpenes in a host cell containing the enhanced DXS enzyme, and transgenic bacterium or plants that express this polypeptide are described.Type: ApplicationFiled: October 20, 2011Publication date: October 17, 2013Applicant: Genoplante-ValorInventors: Phlippe Hugueney, Eric Duchene, Didier Merdinoglu
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Publication number: 20130266581Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.Type: ApplicationFiled: June 25, 2013Publication date: October 10, 2013Inventors: Germaine FUH, Hans-Peter Gerber, Wei-Ching Liang, Frederic Fellouse, Sachdev S. Sidhu, Christian Wiesmann
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Publication number: 20130254933Abstract: Novel insecticidal toxins isolated from Bacillus thuringiensis that are active against lepidopteran insect pests are disclosed. The DNA encoding the insecticidal toxins can be used to transform various prokaryotic and eukaryotic organisms to express the insecticidal toxins. These recombinant organisms can be used to control lepidopteran insects in various environments.Type: ApplicationFiled: November 22, 2011Publication date: September 26, 2013Applicant: SYNGENTA PARTICIPATIONS AGInventor: Vance Kramer
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Publication number: 20130236471Abstract: The present invention relates to anti-IL-36R binding compounds, in particular new anti-IL-36R antibodies and therapeutic and diagnostic methods and compositions for using the same.Type: ApplicationFiled: November 14, 2012Publication date: September 12, 2013Applicant: Boehringer Ingelheim GmbHInventors: Su-Ellen BROWN, Keith Canada, Lukasz Chlewicki, Michael Howell, Detlev Mennerich, Joseph Robert Woska, JR.
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Publication number: 20130219564Abstract: The present invention relates to methods and compositions for improving the efficiency of Agrobacterium- and Rhizobium-mediated plant cell transformation by use of additional transformation enhancer sequences, such as overdrive or TSS sequences, operably linked to a T-DNA border sequence on a recombinant construct that comprises T-DNA.Type: ApplicationFiled: March 19, 2013Publication date: August 22, 2013Applicant: Monsanto Technology LLCInventor: Monsanto Technology LLC
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Patent number: 8513493Abstract: A novel Bacillus thuringiensis crystal protein exhibiting insect inhibitory activity is disclosed. Growth of Lygus insects is significantly inhibited by providing the novel crystal protein in Lygus insect diet. Polynucleotides encoding the crystal protein, transgenic plants and microorganisms that contain the polynucleotides, isolated peptides derived from the crystal protein, and antibodies directed against the crystal protein are also provided. Methods of using the crystal protein and polynucleotides encoding the crystal protein to control Hemipteran insects are also disclosed.Type: GrantFiled: August 28, 2009Date of Patent: August 20, 2013Assignee: Monsanto Technology LLCInventors: James Baum, Stanislaw Flasinski, Gregory R. Heck, Stephen R. Penn, Uma Rao Sukuru, Xiaohong Shi
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Publication number: 20130209464Abstract: A polypeptide is provided that comprises an actinohivin variant polypeptide having an amino acid sequence selected from SEQ ID NOS: 4-12. The polypeptide can be provided as part of a fusion protein that includes the actinohivin variant polypeptide and either a fragment crystallizable domain of an antibody (Fc), a fragment antigen-binding domain of an antibody (Fab), or a single chain variable fragment of an antibody (scFv). Isolated nucleic acid molecules encoding the polypeptides are also provided along with vectors and plant cells capable of expressing the polypeptides. Methods of treating an infection of a subject by an enveloped virus are further provided and include administering an effective amount of the polypeptides to a subject.Type: ApplicationFiled: July 7, 2011Publication date: August 15, 2013Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INCInventors: Nobuyuki Matoba, Adam Husk, Sudha Sankaran
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Publication number: 20130210087Abstract: The present invention provides isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 4, 2011Publication date: August 15, 2013Applicant: NOVOZYMES INC.Inventors: Ye Liu, Lan Tang
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Publication number: 20130212748Abstract: The present invention relates to the isolation and characterization of nucleotide sequences encoding novel insecticidal proteins secreted into the extracellular space from Bacillus thuringiensis and related strains. The proteins are isolated from culture supernatants of Bacillus thuringiensis and related strains and display insecticidal activity against lepidopteran insects including European corn borer (ECB), tobacco budworm (TBW) and diamondback moth (DBM). Insecticidal proteins encoded by nucleotide sequences that hybridize under stringent conditions to the isolated and characterized nucleotide sequences are disclosed. Methods are disclosed for making and using transgenic cells and plants comprising the novel nucleotide sequence of the invention.Type: ApplicationFiled: November 21, 2012Publication date: August 15, 2013Applicant: MONSANTO TECHNOLOGY LLCInventor: MONSANTO TECHNOLOGY LLC
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Patent number: 8507220Abstract: An expression vector is constructed by transferring recombinant tomato mosaic virus (ToMV) cDNA, in which a coat protein gene of ToMV having a suppressor against a virus resistant reaction has been substituted by a GFP gene, into the downstream of a promoter capable of inducing steroid hormone-dependent transcription. In a transformed tobacco BY-2 cell obtained by transferring the above expression vector into a tobacco BY-2 cells, steroid hormone-dependent transcription is induced, thereby enabling the amplification of mRNA of the GFP gene and induction of the expression of GFP.Type: GrantFiled: October 1, 2004Date of Patent: August 13, 2013Assignee: Japan Science and Technology AgencyInventors: Masashi Mori, Koji Dohi, Masayuki Ishikawa, Tetsuo Meshi, Masaki Nishikiori, Atsushi Tamai
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Publication number: 20130203113Abstract: There is provided a method to increase the production of a desired protein in a microorganism by introduction of slowly translated codons in the encoding DNA gene sequence capable of slowing down the translation speed of the ribosomes moving along the mRNA, whereby the ribosomes protect the mRNA from being enzymatically degraded. This increases the stability of the mRNA transcript and thus results in an increased production of the desired protein. Moreover, there is provided a method of decreasing the half-life of a mRNA transcript from a gene encoding a peptide.Type: ApplicationFiled: May 5, 2011Publication date: August 8, 2013Applicant: Kobenhavns UniversitetInventors: Steen Pedersen, Kim Sneppen, Margit Pedersen, Sine Lo Svenningsen, Namiko Mitarai
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Publication number: 20130203968Abstract: Compositions and methods relating to sclerostin binding agents, such as antibodies and polypeptides capable of binding to sclerostin, are provided.Type: ApplicationFiled: April 1, 2013Publication date: August 8, 2013Applicants: UCB PHARMA S.A., AMGEN INC.Inventors: Amgen Inc., UCB Pharma S.A.
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Publication number: 20130205440Abstract: This disclosure concerns compositions and methods for targeting peptides, polypeptides, and proteins to plastids of plastid-containing cells. In some embodiments, the disclosure concerns chloroplast transit peptides that may direct a polypeptide to a plastid, and nucleic acid molecules encoding the same. In some embodiments, the disclosure concerns methods for producing a transgenic plant material (e.g., a transgenic plant) comprising a chloroplast transit peptide, as well as plant materials produced by such methods, and plant commodity products produced therefrom.Type: ApplicationFiled: February 1, 2013Publication date: August 8, 2013Applicant: DOW AGROSCIENCES LLCInventor: Dow AgroSciences LLC
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Publication number: 20130198897Abstract: The present invention is directed to targeting genes and genomes, modifying the activity of enzymes and protein expression in plants. In particular, the present invention relates to methods for reducing the activity of one or more endogenous glycosyltransferases such as N-acetylglucosaminyltransferase, ?(1,2)-xylosyltransferase and a(1,3)-fucosyl-transferase in a plant cell and to plants obtained by said method.Type: ApplicationFiled: March 22, 2011Publication date: August 1, 2013Applicant: PHILIP MORRIS PRODUCTS S.A.Inventors: Karen Keiko Oishi, Dionisius Elisabeth Antonius Florack, Prisca Campanoni, Carlo Massimo Pozzi, Jeremy Catinot, Nicolas Joseph Marie Sierro, Nikolai Valeryevitch Ivanov
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Publication number: 20130189751Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.Type: ApplicationFiled: January 9, 2013Publication date: July 25, 2013Applicant: Genomatica, Inc.Inventors: Robert HASELBECK, John D. TRAWICK, Wei NIU, Anthony P. BURGARD
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Publication number: 20130189279Abstract: The invention relates to binding molecules against Chikungunya virus, which are able of neutralizing Chikungunya virus infectivity, and which can be used with therapeutic, diagnosis or research purposes, as well as to a pharmaceutical composition comprising said binding molecules.Type: ApplicationFiled: April 7, 2011Publication date: July 25, 2013Applicant: Agency for Science, Technology and ResearchInventors: Lucile Warter, Jean-Pierre Abastado, Alessandra Nardin, Cheng-I Wang
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Publication number: 20130180009Abstract: Compositions and methods for regulating expression of heterologous nucleotide sequences in a plant are provided. Compositions include promoter sequences with direct expression in an egg cell or embryonic cell-preferred manner. Such compositions find use in, for example, a method for expressing a heterologous nucleotide sequence in a plant; detection of specific cell types in the ovule and targeted ablation of specific cell types.Type: ApplicationFiled: April 12, 2012Publication date: July 11, 2013Applicant: PIONEER HI BRED INTERNATIONAL INCInventors: MARC C. ALBERTSEN, MARK A. CHAMBERLIN, TIMOTHY W. FOX, SHAI J. LAWIT, BRIAN R. LOVELAND
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Publication number: 20130177539Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Coleopteran plant pest or a Diabrotica plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-236 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is D. virgifera virgifera, D. barberi, D. speciosa, or D. undecimpunctata howardi.Type: ApplicationFiled: March 8, 2013Publication date: July 11, 2013Applicant: PIONEER HI-BRED INTERNATIONALInventor: Pioneer Hi-Bred International
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Publication number: 20130171328Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.Type: ApplicationFiled: June 2, 2011Publication date: July 4, 2013Inventors: Ganesh M. Kishore, Michael Motion, Paula M. Hicks, Jorgen Hansen, Jens Houghton-Larsen, Esben Halkjær Hansen, Michael Dalgaard Mikkelsen, Sabina Tavares, Charlotte Blom
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Publication number: 20130157258Abstract: The invention provides polypeptides comprising an amino acid sequence comprising at least one variation from wild-type HCV NS5B polymerase, the at least one variation selected from the group consisting of cysteine, isoleucine, valine, or proline at amino acid position 419; alanine, valine, or asparagine at amino acid position 482; valine, isoleucine, threonine, or serine at amino acid position 486; and isoleucine at amino acid position 494, as the amino acid positions are defined in SEQ ID NO: 1, and having Hepatitis C Virus (HCV) NS5B polymerase activity. Polynucleotides encoding the polypeptide, antibodies, host cells, compositions, and methods for detecting an HCV NS5B polymerase having resistance to a polymerase inhibitor also are provided.Type: ApplicationFiled: June 15, 2011Publication date: June 20, 2013Applicant: VERTEX PHARMACEUTICALS INCORPORATEDInventors: Douglas J. Bartels, Min Jiang, Tara Lynn Kieffer, Olivier Nicolas
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Publication number: 20130152229Abstract: A ?5 fatty acid desaturase gene, a ?6 fatty acid desaturase gene, and a ?6 fatty-acid-chain elongase gene are isolated from a single species of Marchantiales. By introducing these genes into higher plants, transformed plants which can produce arachidonic acid and eicosapentaenoic acid (EPA) are obtained.Type: ApplicationFiled: January 31, 2011Publication date: June 13, 2013Applicant: Suntory Holdings LimitedInventor: Kanji Ohyama
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Publication number: 20130130379Abstract: The present invention relates to amino acid sequences that are directed against G-protein coupled receptors (GPCRs), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.Type: ApplicationFiled: October 12, 2012Publication date: May 23, 2013Applicant: Ablynx N.V.Inventor: Ablynx N.V.
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Patent number: 8445757Abstract: A novel soybean variety, designated XB55W11 is provided. Also provided are the seeds of soybean variety XB55W11, cells from soybean variety XB55W11, plants of soybean XB55W11, and plant parts of soybean variety XB55W11. Methods provided include producing a soybean plant by crossing soybean variety XB55W11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB55W11, methods for producing other soybean varieties or plant parts derived from soybean variety XB55W11, and methods of characterizing soybean variety XB55W11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB55W11 are further provided.Type: GrantFiled: March 15, 2011Date of Patent: May 21, 2013Assignee: Pioneer Hi Bred International IncInventor: Mark J. Hood
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Patent number: 8445756Abstract: A novel soybean variety, designated XBP46003 is provided. Also provided are the seeds of soybean variety XBP46003, cells from soybean variety XBP46003, plants of soybean XBP46003, and plant parts of soybean variety XBP46003. Methods provided include producing a soybean plant by crossing soybean variety XBP46003 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XBP46003, methods for producing other soybean varieties or plant parts derived from soybean variety XBP46003, and methods of characterizing soybean variety XBP46003. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XBP46003 are further provided.Type: GrantFiled: March 15, 2011Date of Patent: May 21, 2013Assignee: Pioneer Hi Bred International IncInventor: Mark J. Hood
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Publication number: 20130125261Abstract: The present invention refers to a promoter and/or specific regulatory regions for the expression of genes of interest in roots. The invention further describes DNA constructs containing the polynucleotide of the invention operatively linked to a heterologous and/endogenous gene. Besides, the invention refers to the use of these constructions in the form of expression vectors, recombinant vectors and in plants, plant cells or transgenic protoplasts. The invention further describes a method employing such constructs containing the polynucleotide of the invention for the production of plants, plant cells or transgenic protoplasts.Type: ApplicationFiled: March 24, 2011Publication date: May 16, 2013Applicants: Universidad Federal do Para, Embrapa-Empresa Brasileira de Pesquisa AgropecuariInventors: Cláudia Regina Batista De Souza, Francisco José Lima Aragão, Edith Cibelle De Oliveira Moreira, Soelange Bezerra Nascimento, Luiz Joaquim Castelo Blanco Carvalho
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Publication number: 20130121997Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.Type: ApplicationFiled: November 30, 2012Publication date: May 16, 2013Applicant: AMGEN INC.Inventor: Amgen Inc.
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Publication number: 20130117890Abstract: A polynucleotide including a gibberellin 20 oxidase gene and a promoter, more specifically a vascular specific promoter that includes one of (a) a nucleotide sequence of SEQ ID No. 2; (b) a nucleotide sequence of substantial sequence similarity to SEQ ID No. 2; (c) a nucleotide sequence that complements or is able to hybridize to (a) or (b); and (d) a nucleotide sequence which is the reverse complement of (a), (b), or (c). The gibberellin 20 oxidase gene includes one of (1) a nucleotide sequence listed in SEQ ID No. 1 as shown in FIG. 2, a fragment, domain, or feature thereof; (2) a nucleotide sequence of substantial sequence similarity to SEQ ID No. 1; (3) a nucleotide sequence that complements or is able to hybridize to (1) or (2); and (4) a nucleotide sequence which is the reverse complement of (1), (2), or (3). A vector and a transgenic plant that include the gibberellin 20 oxidase gene and the promoter are also provided by the present disclosure.Type: ApplicationFiled: November 24, 2010Publication date: May 9, 2013Applicant: SCG PAPER PUBLIC COMPANY LIMITEDInventors: Sermsawat Tunlayaanukit, Artit Vimoltust
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Publication number: 20130117872Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.Type: ApplicationFiled: September 14, 2012Publication date: May 9, 2013Inventors: Subba Reddy PALLI, Mohan Basavaraju Kumar, Dean Ervin Cress, Ted Tsutomu Fujimoto
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Publication number: 20130108650Abstract: The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to ActRIIB and uses for same.Type: ApplicationFiled: October 27, 2011Publication date: May 2, 2013Applicant: Acceleron Pharma, Inc.Inventors: Ravindra Kumar, Asya Grinberg, Monique Davies, Diana Martik, Janja Cosic, Rachel Kent, David Buckler
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Publication number: 20130101587Abstract: Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.Type: ApplicationFiled: September 14, 2012Publication date: April 25, 2013Applicant: AbGenomics Cooperatief U.A.Inventors: Rong-Hwa Lin, Chung Nan Chang, Pei-Jiun Chen, Chiu-Chen Huang
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Publication number: 20130097735Abstract: The present invention discloses a genus of insect inhibitory proteins that exhibit properties directed to controlling Lepidopteran and/or Hemipteran crop pests, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.Type: ApplicationFiled: April 6, 2012Publication date: April 18, 2013Applicant: MONSANTO TECHNOLOGY LLCInventors: David J. Bowen, Catherine Chay, Artem Evdokimov, Megan N. Schroder, Rachael N. Slightom, Uma Sukuru, Nengbing Tao, Andrew M. Wollacott
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Publication number: 20130096282Abstract: Improved antibodies are provided selected from human, dual-specific, chimeric or humanized antibodies, wherein said human chimeric and humanized antibodies specifically bind to flagellin type A or type B of P. aeruginosa, and said dual-specific antibodies specifically binds to flagella type A and type B of Pseudomonas aeruginosa, and said antibodies are protective against infection caused by P. aeruginosa. These antibodies as well as pharmaceutical composition comprising them are useful for the treatment of indications caused by P. aeruginosa infection.Type: ApplicationFiled: March 1, 2011Publication date: April 18, 2013Applicant: LOSTAM BIOPHARMACEUTICALS LTDInventor: Lewis F. Neville
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Publication number: 20130089897Abstract: The present invention relates to isolated polypeptides having isoamylase activity derived from Dyella japonica and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. The invention also relates to the use of said polypeptide having isoamylase activity for producing glucose syrup, fructose syrup, maltose syrup or maltitol.Type: ApplicationFiled: December 10, 2012Publication date: April 11, 2013Applicant: NOVOZYMES A/SInventor: NOVOZYMES A/S
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Publication number: 20130081155Abstract: This invention relates generally to nucleic acid sequences encoding proteins that are associated with abiotic stress responses and abiotic stress tolerance in plants. In particular, this invention relates to nucleic acid sequences encoding proteins that confer drought, heat, cold, and/or salt tolerance to plants.Type: ApplicationFiled: October 31, 2012Publication date: March 28, 2013Applicant: BASF Plant Science GmbHInventors: Piotr Puzio, Agnes Chardonnens, Harry Wild, Gunnar Plesch, Bryan McKersie
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Publication number: 20130064805Abstract: The present invention provides, as an enzyme which can be used for enzyme replacement therapy for Fabry disease, a protein having ?-galactosidase activity, which shows no allergic adverse side effect, shows a high stability in blood, and can be easily incorporated into a cell of an affected organ. The protein of the present invention is a protein which has acquired ?-galactosidase activity by changing the structure of the active site of wild-type human ?-N-acetylgalactosaminidase.Type: ApplicationFiled: November 2, 2012Publication date: March 14, 2013Applicants: ALTIF LABORATORIES, TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCHInventors: TOKYO METROPOLITAN ORGANIZATION FOR, ALTIF LABORATORIES
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Publication number: 20130064830Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.Type: ApplicationFiled: November 6, 2012Publication date: March 14, 2013Applicant: UCB MANUFACTURING, INC.Inventor: UCB MANUFACTURING, INC.
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Publication number: 20130064829Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.Type: ApplicationFiled: November 6, 2012Publication date: March 14, 2013Applicant: UCB MANUFACTURING, INC.Inventor: UCB MANUFACTURING, INC.
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Publication number: 20130058927Abstract: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.Type: ApplicationFiled: October 31, 2012Publication date: March 7, 2013Applicant: GENENTECH, INC.Inventor: GENENTECH, INC.