Introduction Of A Polynucleotide Molecule Into Or Rearrangement Of A Nucleic Acid Within A Plant Cell Patents (Class 435/468)
  • Patent number: 10669317
    Abstract: Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 2, 2020
    Assignee: Monsanto Technology LLC
    Inventors: James A. Baum, Thomas A. Cerruti, Crystal L. Dart, Leigh H. English, Stanislaw Flasinski, Xiaoran Fu, Victor M. Guzov, Arlene R. Howe, Jay P. Morgenstern, James K. Roberts, Sara A. Salvador, Jinling Wang
  • Patent number: 10669555
    Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: June 2, 2020
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Andre Roger Abad, David Charles Cerf, Scott Henry Diehn, Hua Dong, Xiaomei Shi, Thomas Chad Wolfe, Lan Zhou
  • Patent number: 10640779
    Abstract: An Engineered Transgene Integration Platform (ETIP) is described that can be inserted randomly or at targeted locations in plant genomes to facilitate rapid selection and detection of a GOI that is perfectly targeted (both the 5? and 3? ends) at the ETIP genomic location. One element in the subject disclosure is the introduction of specific double stranded breaks within the ETIP. In some embodiments, an ETIP is described using zinc finger nuclease binding sites, but may utilize other targeting technologies such as meganucleases, CRISPRs, TALs, or leucine zippers. Also described are compositions of, and methods for producing, transgenic plants wherein the donor or payload DNA expresses one or more products of an exogenous nucleic acid sequence (e.g. protein or RNA) that has been stably-integrated into an ETIP in a plant cell. In embodiments, the ETIP facilitates testing of gene candidates and plant expression vectors from ideation through Development phases.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: May 5, 2020
    Assignee: Dow AgroSciences LLC
    Inventors: Noel Cogan, John Forster, Matthew Hayden, Tim Sawbridge, German Spangenberg, Steven R. Webb, Manju Gupta, W. Mike Ainley, Matthew J. Henry, John Mason, Sandeep Kumar, Stephen Novak
  • Patent number: 10626151
    Abstract: Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC4472, TIC4472PL, TIC1425, TIC2613, and TIC2613PL. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC4472, TIC4472PL, TIC1425, TIC2613, and TIC2613PL pesticidal proteins are also provided.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: April 21, 2020
    Assignee: Monsanto Technology LLC
    Inventors: David J. Bowen, Catherine A. Chay, Arlene R. Howe, Uma Kesanapalli
  • Patent number: 10612035
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide. Additionally the present invention relates to mutant E. coli cells that contain mutated EPSPS genes.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: April 7, 2020
    Assignee: CIBUS US LLC
    Inventors: Greg F. W. Gocal, Mark E. Knuth, Peter R. Beetham
  • Patent number: 10568285
    Abstract: A novel maize variety designated PH473G and seed, plants and plant parts thereof are provided. Methods for producing a maize plant comprise crossing maize variety PH473G with another maize plant are provided. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH473G through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby are provided. Hybrid maize seed, plants or plant parts are produced by crossing the variety PH473G or a locus conversion of PH473G with another maize variety.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: February 25, 2020
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventor: Marco Zanirato
  • Patent number: 10555494
    Abstract: The invention relates to the alfalfa variety designated R410A131. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety R410A131. Also provided by the invention are tissue cultures of the alfalfa variety R410A131 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety R410A131 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: February 11, 2020
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10555493
    Abstract: The invention relates to the alfalfa variety designated R410A109. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety R410A109. Also provided by the invention are tissue cultures of the alfalfa variety R410A109 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety R410A109 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: February 11, 2020
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10555496
    Abstract: The invention relates to the alfalfa variety designated R410M327. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety R410M327. Also provided by the invention are tissue cultures of the alfalfa variety R410M327 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety R410M327 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: February 11, 2020
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10555495
    Abstract: The invention relates to the alfalfa variety designated R410A136. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety R410A136. Also provided by the invention are tissue cultures of the alfalfa variety R410A136 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety R410A136 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: February 11, 2020
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10531631
    Abstract: The invention relates to the alfalfa variety designated 410A177. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety 410A177. Also provided by the invention are tissue cultures of the alfalfa variety 410A177 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety 410A177 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: January 14, 2020
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10531633
    Abstract: The invention relates to the alfalfa variety designated 49H344. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety 49H344. Also provided by the invention are tissue cultures of the alfalfa variety 49H344 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety 49H344 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: January 14, 2020
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10531632
    Abstract: The invention relates to the alfalfa variety designated 410A179. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety 410A179. Also provided by the invention are tissue cultures of the alfalfa variety 410A179 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety 410A179 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: January 14, 2020
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10501732
    Abstract: There is disclosed a mutant, non-naturally occurring or transgenic plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a threonine synthase and having at least 90% sequence identity to SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3 or at least 87% sequence identity to SEQ ID NO:4, or SEQ ID NO:5; (ii) a polypeptide encoded by any one of said polynucleotides set forth in (i); or (iii) a polypeptide having at least 95% sequence identity to SEQ ID NO:6, SEQ ID NO:7 or SEQ ID NO:8; or (iv) a construct, vector or expression vector comprising the polynucleotide as set forth in (i).
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: December 10, 2019
    Assignee: Philip Morris Products S.A.
    Inventors: Lucien Bovet, Nicolas Sierro
  • Patent number: 10494409
    Abstract: Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: December 3, 2019
    Assignee: Monsanto Technology LLC
    Inventors: James A. Baum, Thomas A. Cerruti, Crystal L. Dart, Leigh H. English, Stanislaw Flasinski, Xiaoran Fu, Victor M. Guzov, Arlene R. Howe, Jay P. Morgenstern, James K. Roberts, Sara A. Salvador, Jinling Wang
  • Patent number: 10485214
    Abstract: The invention relates to the alfalfa variety designated R411A107. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety R411A107. Also provided by the invention are tissue cultures of the alfalfa variety R411A107 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety R411A107 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: November 26, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10435702
    Abstract: The present invention provides novel compositions for use to enhance crop performance. Specifically, the present invention provides for delayed senescence and/or improved yield enhancement in various crops. The present invention also provides for combinations of compositions and methods that provide for delayed senescence and/or improved yield.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: October 8, 2019
    Assignee: Monsanto Technology LLC
    Inventors: Jill Deikman, Steven H. Schwartz, Wei Zheng, Suzan Herma Elisabeth Johanna Gabriels, Michelle C. Hresko, Xiangqian Li, Nengbing Tao, Deryck J. Williams, Hui Xiong
  • Patent number: 10412925
    Abstract: The invention relates to the alfalfa variety designated RRL43M104. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety RRL43M104. Also provided by the invention are tissue cultures of the alfalfa variety RRL43M104 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety RRL43M104 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: September 17, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10405508
    Abstract: A novel soybean variety, designated 5PKYK65 is provided. Also provided are the seeds of soybean variety 5PKYK65, cells from soybean variety 5PKYK65, plants of soybean 5PKYK65, and plant parts of soybean variety 5PKYK65. Methods provided include producing a soybean plant by crossing soybean variety 5PKYK65 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PKYK65, methods for producing other soybean varieties or plant parts derived from soybean variety 5PKYK65, and methods of characterizing soybean variety 5PKYK65. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PKYK65 are further provided.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: September 10, 2019
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Thomas Charles Corbin, Randy Leroy Kallem, Tara Lynch Slaminko
  • Patent number: 10357012
    Abstract: The invention relates to the alfalfa variety designated RRL43M113. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety RRL43M113. Also provided by the invention are tissue cultures of the alfalfa variety RRL43M113 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety RRL43M113 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: July 23, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10356999
    Abstract: A novel maize variety designated PH2DPF and seed, plants and plant parts thereof are provided. Methods for producing a maize plant comprise crossing maize variety PH2DPF with another maize plant are provided. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH2DPF through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby are provided. Hybrid maize seed, plants or plant parts are produced by crossing the variety PH2DPF or a locus conversion of PH2DPF with another maize variety.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: July 23, 2019
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Dario Prada, Matthew David Smalley
  • Patent number: 10357011
    Abstract: The invention relates to the alfalfa variety designated RRL43A108. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety RRL43A108. Also provided by the invention are tissue cultures of the alfalfa variety RRL43A108 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety RRL43A108 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: July 23, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10342208
    Abstract: The invention relates to the alfalfa variety designated RRL43M114. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety RRL43M114. Also provided by the invention are tissue cultures of the alfalfa variety RRL43M114 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety RRL43M114 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: July 9, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10342209
    Abstract: The invention relates to the alfalfa variety designated RRL43M119. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety RRL43M119. Also provided by the invention are tissue cultures of the alfalfa variety RRL43M119 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety RRL43M119 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: July 9, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10334812
    Abstract: The invention relates to the alfalfa variety designated RRL913T404. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety RRL913T404. Also provided by the invention are tissue cultures of the alfalfa variety RRL913T404 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety RRL913T404 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: July 2, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Julie Ho, Peter Reisen
  • Patent number: 10327412
    Abstract: The invention relates to the alfalfa variety designated RRL43M115. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety RRL43M115. Also provided by the invention are tissue cultures of the alfalfa variety RRL43M115 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety RRL43M115 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: June 25, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10327413
    Abstract: The invention relates to the alfalfa variety designated RRL913T455. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety RRL913T455. Also provided by the invention are tissue cultures of the alfalfa variety RRL913T455 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety RRL913T455 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: June 25, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Julie Ho, Peter Reisen
  • Patent number: 10321648
    Abstract: A novel maize variety designated PH2F62 and seed, plants and plant parts thereof are provided. Methods for producing a maize plant comprise crossing maize variety PH2F62 with another maize plant are provided. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH2F62 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby are provided. Hybrid maize seed, plants or plant parts are produced by crossing the variety PH2F62 or a locus conversion of PH2F62 with another maize variety.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: June 18, 2019
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Mark Jacob Gadlage, Matthew David Smalley
  • Patent number: 10314279
    Abstract: The invention relates to the alfalfa variety designated RRL43Q109. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety RRL43Q109. Also provided by the invention are tissue cultures of the alfalfa variety RRL43Q109 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety RRL43Q109 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: June 11, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Mark McCaslin, Peter Reisen
  • Patent number: 10314280
    Abstract: The invention relates to the alfalfa variety designated 49W202. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety 49W202. Also provided by the invention are tissue cultures of the alfalfa variety 49W202 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety 49W202 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: June 11, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Peter Reisen, Mark McCaslin
  • Patent number: 10299460
    Abstract: The invention relates to the alfalfa variety designated 68M802. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety 68M802. Also provided by the invention are tissue cultures of the alfalfa variety 68M802 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety 68M802 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: May 28, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Peter Reisen, Mark McCaslin
  • Patent number: 10301661
    Abstract: The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analog, an insulin mediator homolog, or an insulin mediator inhibitor is also described. The method includes providing a fagopyritol synthase, providing a substrate comprising a galactosyl donor and a galactosyl acceptor, and combining the fagopyritol synthase with the substrate under conditions effective produce a fagopyritol, an insulin mediator, an insulin mediator analog, an insulin mediator homolog, or an insulin mediator inhibitor.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: May 28, 2019
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Ralph L. Obendorf, Takashi Ueda
  • Patent number: 10299459
    Abstract: The invention relates to the alfalfa variety designated 610W265. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety 610W265. Also provided by the invention are tissue cultures of the alfalfa variety 610W265 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety 610W265 with itself or another alfalfa variety and plants produced by such methods.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: May 28, 2019
    Assignee: Forage Genetics International, LLC
    Inventors: Peter Reisen, Mark McCaslin
  • Patent number: 10239891
    Abstract: Disclosed are compounds, compositions and methods for detecting remnant cancer cells in a tissue sample.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: March 26, 2019
    Assignee: Indicator Systems International, Inc.
    Inventors: Gerald F. Swiss, Richard J. Pariza, Robert M. Moriarty
  • Patent number: 10233217
    Abstract: Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: March 19, 2019
    Assignee: Monsanto Technology LLC
    Inventors: James A. Baum, Sara A. Salvador, Jinling Wang, Stanislaw Flasinski, Thomas A. Cerruti, Crystal L. Dart, Leigh H. English, Xiaoran Fu, Victor M. Guzov, Arlene R. Howe, Jay P. Morgenstern, James K. Roberts
  • Patent number: 10174331
    Abstract: Disclosed herein are methods and compositions for homology-independent targeted insertion of donor molecules into the genome of a cell.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: January 8, 2019
    Assignees: Sangamo Therapeutics, Inc., Dow AgroSciences LLC
    Inventors: Gregory J. Cost, Fyodor Urnov, W. Michael Ainley, Joseph F. Petolino, Jayakumar Pon Samuel, Steven R. Webb, Lakshmi Sastry-Dent
  • Patent number: 10166255
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: January 1, 2019
    Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA, INTIMA BIOSCIENCE, INC., THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES
    Inventors: Branden Moriarity, Beau Webber, R. Scott McIvor, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • Patent number: 10143158
    Abstract: According to the invention, there is provided seed and plants of the corn variety designated CV466191. The invention thus relates to the plants, seeds and tissue cultures of the variety CV466191, and to methods for producing a corn plant produced by crossing a corn plant of variety CV466191 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV466191 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV466191.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: December 4, 2018
    Assignee: Monsanto Technology LLC
    Inventor: Marvin L. Boerboom
  • Patent number: 10100341
    Abstract: Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty acid hydroxylase, a desaturase enzyme, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: October 16, 2018
    Assignee: CORBION BIOTECH, INC.
    Inventors: Scott Franklin, Aravind Somanchi, Janice Wee, George Rudenko, Jeffrey L. Moseley, Walter Rakitsky, Xinhua Zhao, Riyaz Bhat
  • Patent number: 10100328
    Abstract: The present invention provides a transgenic corn event MON87460, and cells, seeds, and plants comprising DNA diagnostic for the corn event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for MON87460 in a sample, methods for detecting the presence of MON87460 event polynucleotides in a sample, and probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of MON87460 in a sample. The present invention also provides methods of breeding with MON87460 to produce water deficit tolerance corn plants.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: October 16, 2018
    Assignee: Monsanto Technology LLC
    Inventors: Kim A. Beazley, Paolo Castiglioni, Mark A. Dizigan, Rebecca A. Kelly, John A. Korte, Amanda Rock, Christine Voyles
  • Patent number: 10051826
    Abstract: The invention relates to the soybean variety designated 01064189. Provided by the invention are the seeds, plants and derivatives of the soybean variety 01064189. Also provided by the invention are tissue cultures of the soybean variety 01064189 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 01064189 with itself or another soybean variety and plants produced by such methods.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: August 21, 2018
    Assignee: Monsanto Technology LLC
    Inventor: Heinrich S. Wohleser
  • Patent number: 10000769
    Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: June 19, 2018
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Andre R. Abad, Hua Dong, Sue B. Lo, Xiaomei Shi, Thomas Chad Wolfe
  • Patent number: 9988638
    Abstract: This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a minimal core promoter element from a Arabidopsis thaliana Ubiquitin-10 gene promoter or Cassava Vein Mosaic Virus promoter, and the full-length nucleotide sequence elements from a Cassava Vein Mosaic Virus promoter. Some embodiments relate to a synthetic CsVMV bi-directional promoter that functions in plants to promote transcription of two operably linked nucleotide sequences.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: June 5, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: Sandeep Kumar, Toby Cicak, Heather Leigh Robinson, Dayakar Reddy Pareddy, Wei Chen
  • Patent number: 9974271
    Abstract: A novel maize variety designated PH25V7 and seed, plants and plant parts thereof are provided. Methods for producing a maize plant comprise crossing maize variety PH25V7 with another maize plant are provided. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH25V7 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby are provided. Hybrid maize seed, plants or plant parts are produced by crossing the variety PH25V7 or a locus conversion of PH25V7 with another maize variety.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: May 22, 2018
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventor: Martin Arbelbide
  • Patent number: 9930843
    Abstract: The invention provides seed and plants of the hybrid corn variety designated X13512. The invention thus relates to the plants, seeds and tissue cultures of the variety X13512, and to methods for producing a corn plant produced by crossing a corn plant of variety X13512 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety X13512.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: April 3, 2018
    Assignee: Agrigenetics, Inc.
    Inventor: Daniel J. Martinelli
  • Patent number: 9926334
    Abstract: Disclosed are compounds, compositions and methods for detecting remnant cancer cells in a tissue sample.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: March 27, 2018
    Assignee: Indicator Systems International, Inc.
    Inventors: Gerald F. Swiss, Richard J. Pariza, Robert M. Moriarty
  • Patent number: 9854778
    Abstract: The present invention provides a transgenic alfalfa event KK179-2. The invention also provides cells, plant parts, seeds, plants, commodity products related to the event, and DNA molecules that are unique to the event and were created by the insertion of transgenic DNA into the genome of a alfalfa plant. The current invention also provides anti-sense-oriented RNA gene suppression agents in the form of a loop of anti-sense-oriented RNA that is produced in the cells of transgenic alfalfa. In addition, the invention also provides methods for detecting the presence of said alfalfa event nucleotide sequences in a sample, probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of said alfalfa event.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: January 2, 2018
    Assignees: Monsanto Technology LLC, Forage Genetics International, LLC
    Inventor: William Hiatt
  • Patent number: 9832942
    Abstract: The present invention provides methods of marker-assisted selection for high oleic/low linolenic traits in canola and in other oil seed crop species, as well as isolated nucleic acids for use as molecular markers in such methods. In particular, molecular markers and Brassica nucleic acid corresponding to fad2 and fad3 gene mutations are disclosed. The markers of the present invention are highly useful for the direct selection of desirable fad2 and fad3 alleles during marker-assisted trait introgression and breeding. In one aspect of the embodiment, two single nucleotide polymorphism (SNP) markers are provided that correspond to the alleles. Thus, the present invention advantageously permits one of skill in the art to breed for the molecular markers described herein, or derivatives thereof, rather than breeding for a high oleic/low linolenic phenotype.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: December 5, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Xueyi Hu, Mandy Lynne Sullivan-Gilbert, Manju Gupta, Steven Arnold Thompson
  • Patent number: 9738879
    Abstract: Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: August 22, 2017
    Assignee: Duke University
    Inventors: Charles Gersbach, David Ousterout
  • Patent number: 9675071
    Abstract: This invention relates generally to the detection of genetic differences among soybeans. More particularly, the invention relates to soybean quantitative trait loci (QTL) for tolerance to protoporphyrinogen oxidase inhibitors, to soybean plants possessing these QTLs, which map to a novel chromosomal region, and to genetic markers that are indicative of phenotypes associated with protoporphyrinogen oxidase inhibitor tolerance. Methods and compositions for use of these markers in genotyping of soybean and selection are also disclosed.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: June 13, 2017
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Donald Kyle, Mark D. Vogt