Introduction Of A Polynucleotide Molecule Into Or Rearrangement Of A Nucleic Acid Within A Plant Cell Patents (Class 435/468)
  • Patent number: 8927818
    Abstract: The present invention is in the field of soybean variety BN1012650 breeding and development. The present invention particularly relates to the soybean variety BN1012650 and its progeny, and methods of making BN1012650.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: January 6, 2015
    Assignee: Syngenta Participations AG
    Inventors: Kevin Chris Threlkeld, Roger L McBroom
  • Patent number: 8927819
    Abstract: The present invention is in the field of soybean variety WN1012862 breeding and development. The present invention particularly relates to the soybean variety WN1012862 and its progeny, and methods of making WN1012862.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: January 6, 2015
    Assignee: Syngenta Participations AG
    Inventors: Kevin Chris Threlkeld, Keith Merle Bilyeu
  • Patent number: 8927806
    Abstract: The present invention relates to the isolation, purification, characterization and use of the plant Snf1-related protein kinase (SnRK) gene and genetic products. The invention includes isolated and purified SnRK DNA and relates to methods of regulating water loss and plant drought tolerance, sucrose content, starch content, seed oil content, fatty acid synthesis, seed oil acyl composition, seed size/weight, resistance/tolerance to biotic stresses, increased root biomass, and/or carbon flux into other seed components, plant, using the gene, and to tissues and plants transformed with the gene. The invention also relates to transgenic plants, plant tissues and plant seeds having a genome containing an introduced DNA sequence of the invention, and a method of producing such plants and plant seeds.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: January 6, 2015
    Assignee: DowAgroSciences, LLC
    Inventors: Zhifu Zheng, Thomas W. Greene
  • Patent number: 8927830
    Abstract: An inbred corn line designated I9545 is disclosed. The invention relates to the plants and seeds of inbred corn line I9545 and methods for producing a corn plant produced by crossing the inbred corn line I9545 with itself or with another corn plant. The invention also relates to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic corn plants and plant parts produced by those methods. The invention also relates to corn cultivars and plant parts derived from inbred corn line I9545 and to methods for producing other corn cultivars, lines, or plant parts derived from inbred corn line I9545, and to the corn plants and parts derived from use of those methods. The invention further relates to hybrid corn seeds, plants, and plant parts produced by crossing inbred corn line I9545 with another corn cultivar.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: January 6, 2015
    Assignee: Beck's Superior Hybrids, Inc.
    Inventors: Benjamin Earl Orebaugh, Kevin James Cavanaugh
  • Patent number: 8927816
    Abstract: The present invention is in the field of soybean variety BK1011572 breeding and development. The present invention particularly relates to the soybean variety BK1011572 and its progeny, and methods of making BK1011572.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 6, 2015
    Assignee: Syngenta Participations AG
    Inventor: Kurt Milan Lindenbaum
  • Patent number: 8927809
    Abstract: Transgenic soybean seed having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of non-transgenic, null segregant soybean seed are described. DGAT genes from Yarrowia Lipolytica are used to achieve the increase in seed storage lipids.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: January 6, 2015
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Knut Meyer, William D. Hitz, Narendra S. Yadav, Howard Glenn Damude
  • Patent number: 8927826
    Abstract: A novel maize variety designated X13C762 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X13C762 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X13C762 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X13C762, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X13C762. This invention further relates to methods for producing maize varieties derived from maize variety X13C762.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: January 6, 2015
    Assignee: Pioneer Hi Bred International Inc
    Inventors: Terry R. Colbert, Charles Thomas Cunnyngham, Joseph D. Anderson, Thomas Russell Henry, Daniel Joseph Pohl, Randall Newton Holley
  • Publication number: 20150004656
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: September 15, 2014
    Publication date: January 1, 2015
    Inventors: Lan Tang, Ye Liu, Junxin Duan, Yu Zhang, Christian Joergensen, Randall Kramer
  • Publication number: 20150007365
    Abstract: The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels in plants, and plants containing such promoters or promoter control elements.
    Type: Application
    Filed: September 3, 2014
    Publication date: January 1, 2015
    Inventors: Richard SCHNEEBERGER, Emilio MARGOLLES-CLARK, Tatiana TATARINOVA, Yiwen FANG, Nickolai ALEXANDROV, Leonard MEDRANO, Roger PENNELL, Noah THEISS, Danielle GRIZARD, Shauna J. DAVIS, Dennis ROBLES, Michael PORTEREIKO
  • Patent number: 8921655
    Abstract: The present invention relates to the field of functional analysis of Jatropha genes on a genomic scale. More specifically, the present invention relates to a method for high-throughtput functional analysis of Jatropha curcas genes on a genomic scale using virus-induced gene silencing. The method involves use of the tobacco rattle virus (TRV).
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: December 30, 2014
    Assignee: Joil (S) Pte Ltd.
    Inventors: Jian Ye, Nam Hai Chua, Jing Qu
  • Patent number: 8921671
    Abstract: The invention provides seed and plants of tomato line FDR-9Q08131. The invention thus relates to the plants, seeds and tissue cultures of tomato line FDR-9Q08131, and to methods for producing a tomato plan produced by crossing such plants with themselves or with another tomato plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: December 30, 2014
    Assignee: Seminis Vegetable Seeds, Inc.
    Inventor: James D. Frantz
  • Patent number: 8921112
    Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: December 30, 2014
    Assignees: Dow AgroSciences LLC, Sangamo BioSciences, Inc.
    Inventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey Miller, Fyodor Urnov
  • Patent number: 8921110
    Abstract: Provided are methods for generating iris plants having flowers expressing red, red/orange, or orange/red color, previously non-existing in this plant genus, thereby expanding the color palette of, and generating new and exciting varieties of, ornamental plants. These methods employ capsanthin-capsorubin synthase-encoding nucleotide sequences, and are also applicable to other genera, species, cultivars, and varieties of ornamental plants in which red, red/orange, or orange/red flowers have been desired. The nucleotide sequences and methods disclosed herein can be applied to genera, species, cultivars, and varieties of ornamental plants that produce yellow pigments, or yellow/orange flowers, but no red flowers, to produce novel red-, red/orange, or orange/red-flowering plants.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: December 30, 2014
    Assignee: Oregon State University
    Inventors: Zoran Jeknic, Tony H. H. Chen
  • Patent number: 8921651
    Abstract: The present invention is directed to plants that display an improved oil quantity phenotype or an improved meal quality phenotype due to altered expression of an HIO nucleic acid. The invention is further directed to methods of generating plants with an improved oil quantity phenotype or improved meal quality phenotype.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: December 30, 2014
    Assignee: Agrigenetics, Inc.
    Inventors: John P. Davies, Hein Tsoeng (Medard) Ng
  • Patent number: 8921538
    Abstract: The invention provides the isolated promoter polynucleotide sequence of SEQ ID NO: 1 from perennial ryegrass (Lolium perenne L.), and fragments and variants thereof. The invention also provides constructs, plant cells and plant genetically modified to contain the promoter polynucleotide. The invention also provides methods for producing plants with altered gene expression and traits via genetic transformation of plants with the promoter polynucleotide.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: December 30, 2014
    Assignee: Vialactia Biosciences (NZ) Limited
    Inventors: Sathish Puthigae, Jonathan Robert Phillips, Nimali Piyushika Withana, Claudia Jeannette Smith-Espinoza, Catherine Jane Bryant, Shivendra Bajaj, Kerry Robert Templeton
  • Patent number: 8921673
    Abstract: A rice hybrid designated HR120001 (ATCC PTA-13290) is disclosed. The invention relates to the seeds of rice hybrid HR120001, to the plants of rice hybrid HR120001 and to methods for producing a rice plant produced by crossing the hybrid HR120001 with itself or another rice plant. The invention further relates to hybrid rice seeds and plants produced by crossing the hybrid HR120001 with another rice plant. This invention further relates to growing and producing blends of rice seeds comprised of seeds of rice hybrid HR120001 with rice seed of one, two, three, four, or more of another rice hybrid, rice variety or rice inbred.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: December 30, 2014
    Assignee: RiceTec, Inc.
    Inventor: Jose V. Re
  • Patent number: 8921648
    Abstract: Methods for increasing yield of fermentable sugars from plant stover are provided. The methods include using plants homozygous for two brown midrib mutations, bm1 and bm3. The methods also include using plants homozygous for a mutation in a gene that results in reduced cinnamyl alcohol dehydrogenase activity, and a mutation in a gene that results in reduced 5-hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity. The methods also include using transgenic plants that have reduced cinnamyl alcohol dehydrogenase activity and reduced 5-hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity in comparison with wild-type plants.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: December 30, 2014
    Assignee: Purdue Research Foundation
    Inventors: Willem Evert Vermerris, Michael R. Ladisch, Nathan S. Mosier
  • Patent number: 8921657
    Abstract: The present invention relates to an expression cassette for regulating seed-specific expression of a polynucleotide of interest, said expression cassette comprising a transcription regulating nucleotide sequence, to a vector comprising said expression cassette, host cells and transgenic plants comprising the expression cassette, and methods of producing said transgenic plants.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: December 30, 2014
    Assignee: BASF Plant Science Company GmbH
    Inventors: Huihua Fu, Jeffrey A. Brown, Kirk Francis, Hee-Sook Song
  • Patent number: 8921670
    Abstract: The invention provides seed and plants of tomato hybrid EX01420200 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of tomato hybrid EX01420200 and the parent lines thereof, and to methods for producing a tomato plant produced by crossing such plants with themselves or with another tomato plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: December 30, 2014
    Assignee: Seminis Vegetable Seeds, Inc.
    Inventors: Charles Wayne Fowler, Jaap Hoogstraten
  • Publication number: 20140377870
    Abstract: The present invention provides reagents and methods for improved homologous recombination.
    Type: Application
    Filed: August 29, 2014
    Publication date: December 25, 2014
    Applicant: Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Ariz
    Inventors: Bertram JACOBS, Stacy White, Kip Conwell, Jeffrey Langland, James Jancovich, Karen Kibler
  • Publication number: 20140380529
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Inventor: Nikolaj Spodsberg
  • Patent number: 8916749
    Abstract: Methods and compositions for modulating plant development are provided. Polynucleotide sequences and amino acid sequences encoding isopentenyl transferase (IPT) polypeptides are provided. The sequences can be used in a variety of methods including modulating root development, modulating floral development, modulating leaf and/or shoot development, modulating senescence, modulating seed size and/or weight, and modulating tolerance of plants to abiotic stress. Polynucleotides comprising an IPT promoter are also provided. The promoter can be used to regulate expression of a sequence of interest. Transformed plants, plant cell, tissues, and seed are also provided.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: December 23, 2014
    Assignee: Pioneer Hi Bred International Inc
    Inventor: Norbert Brugiere
  • Patent number: 8916745
    Abstract: The invention provides compositions and methods for manipulating the exchange of water and/or carbon dioxide (CO2) through plant stomata by controlling CO2 sensor genes. The invention provides compositions and methods for enhancing or optimizing biomass accumulation in a plant. The invention provides compositions and methods for for opening or closing a stomatal pore on a guard cell in the epidermis of a plant. The invention provides compositions and methods for increasing or decreasing oxygenation efficiency and/or carbon fixation in a guard cell in the epidermis of a plant by manipulating expression of a ribulose-1,5-bisphosphate carboxylase/oxygenase. The invention provides promoters for regulating expression of a nucleic acid in a plant guard cell.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: December 23, 2014
    Assignee: The Regents of the University of California
    Inventors: Julian Schroeder, Maria Israelsson-Nordstrom, Josef M. Kuhn, Yingzhen Yang, Honghong Hu, Aurelien Boisson-Dernier
  • Patent number: 8916746
    Abstract: Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a DTP21 polypeptide.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: December 23, 2014
    Assignees: Japan Tobacco, Inc., E. I. du Pont de Neumours and Company, Pioneer Hi-Bred International, Inc.
    Inventors: Masakazu Kashihara, Toshiyuki Komori, Ichiro Oka, Satoru Usami, Norio Kato, Yukoh Hiei, Yoshimitsu Takakura, Toshihiko Komari, Teruyuki Imayama, Scott V. Tingey, Hajime Sakai, Marc C. Albertsen, Stanley Luck
  • Patent number: 8916377
    Abstract: The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a promoter for the gene encoding Sorghum bicolor RCc3. A method for expressing a heterologous nucleotide sequence in a plant using the promoter sequences disclosed herein is provided. The method comprises transforming a plant or plant cell with a nucleotide sequence operably linked to one of the promoters of the present invention.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: December 23, 2014
    Assignee: Pioneer Hi Bred International Inc
    Inventors: Scott Diehn, Brooke Peterson-Burch
  • Publication number: 20140373196
    Abstract: A method to generate siRNAs in vivo is described, as are constructs and compositions useful in the method. The method does not depend on the use of DNA or synthetic constructs that contain inverted duplications or dual promoters so as to form perfect or largely double-stranded RNA. Rather, the method depends on constructs that yield single-stranded RNA transcripts, and exploits endogenous or in vivo-produced miRNAs or siRNAs to initiate production of siRNAs. The miRNAs or siRNAs guide cleavage of the transcript and set the register for production of siRNAs (usually 21 nucleotides in length) encoded adjacent to the initiation cleavage site within the construct. The method results in specific formation of siRNAs of predictable size and register (phase) relative to the initiation cleavage site. The method can be used to produce specific siRNAs in vivo for inactivation or suppression of one or more target genes or other entities, such as pathogens.
    Type: Application
    Filed: August 25, 2014
    Publication date: December 18, 2014
    Inventors: James C. Carrington, Edwards Allen
  • Publication number: 20140371477
    Abstract: The present invention relates to recombinant cells, particularly recombinant plant cells, which are capable of producing dihydrosterculic acid and/or derivatives thereof. The present invention also relates to methods of producing oil comprising dihydrosterculic acid and/or derivatives thereof.
    Type: Application
    Filed: December 21, 2012
    Publication date: December 18, 2014
    Applicants: Commomwealth Scientific and Industrial Research Organisation, Grains Research and Delvelopment Corporation
    Inventors: Craig Christopher Wood, Fatima Naim, Surinder Pal Singh, Shoko Okada
  • Publication number: 20140370603
    Abstract: Disclosed herein are transgenic cells expressing a heterologous nucleic acid encoding a prephenate dehydrogenase (PDH) protein, a heterologous nucleic acid encoding a homogentisate solanesyl transferase (HST) protein, a heterologous nucleic acid encoding a deoxyxylulose phosphate synthase (DXS) protein, or a combination of two or more thereof. In particular examples, the disclosed transgenic cells have increased plastoquinone levels. Also disclosed are methods of increasing cell growth rates or production of biomass by cultivating transgenic cells expressing a heterologous nucleic acid encoding a PDH protein, a heterologous nucleic acid encoding an HST protein, a heterologous nucleic acid encoding a DXS protein, or a combination of two or more thereof under conditions sufficient to produce cell growth or biomass.
    Type: Application
    Filed: June 17, 2014
    Publication date: December 18, 2014
    Applicant: Los Alamos National Security, LLC
    Inventors: Richard T. Sayre, Sowmya Subramanian, Edgar Cahoon
  • Patent number: 8912397
    Abstract: Disclosed is the seed of a novel soybean variety, designated 75408-57N, a sample of which is deposited under ATCC Accession No. PTA-121159. Also disclosed are plants, or parts thereof, grown from the seed of the variety, plants having the morphological and physiological characteristics of the 75408-57N variety, and methods of using the plant or parts thereof in a soybean breeding program.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: December 16, 2014
    Assignee: Dairyland Seed Co, Inc.
    Inventor: Robert E. Moore
  • Patent number: 8912395
    Abstract: The present invention is directed to plants that display an improved oil quantity phenotype or an improved meal quality phenotype due to altered expression of an IMQ nucleic acid. The invention is further directed to methods of generating plants with an improved oil quantity phenotype or improved meal quality phenotype.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: December 16, 2014
    Assignee: Agrigenetics, Inc.
    Inventors: John P. Davies, Hein Tsoeng (Medard) Ng, D. Ry Wagner
  • Patent number: 8912393
    Abstract: Disclosed herein is an activation tagging construct for maize, resulting tagged populations and plants. In one example, an activation tagging DNA construct includes a coding sequence for a transposase, a detectable reporter (such as anthocyanin regulatory genes B-Peru and C1) and a non-autonomous transposable T-DNA cassette. For example, the transposable T-DNA cassette is inserted into the detectable reporter encoding region such that the B-Peru and C1 genes express anthocyanins in a cell containing the maize activation tagging DNA construct only upon excision of the transposable cassette. Methods of generating a tagged population of maize plants include transforming a maize plant cell or tissue with the disclosed constructs.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: December 16, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: John P. Davies, Vaka S. Reddy, William M. Ainley, Xing Liang Liu, D. Ry Wagner
  • Patent number: 8912145
    Abstract: A vaccine composition for prophylaxis and/or therapy of Alzheimer's disease, which comprises a fusion protein prepared by inserting a single or tandemly repeated multiple copies of amyloid ? antigenic peptide having 5 to 15 continuous amino acid residues derived from the N-terminus of amyloid ? peptide into a wild type seed storage protein.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: December 16, 2014
    Assignee: Hokko Chemical Industry Co., Ltd.
    Inventors: Teruhiko Terakawa, Hisakazu Hasegawa, Yasushi Shimada, Atsushi Takahashi, Takeshi Kawarabayashi, Mikio Shoji
  • Publication number: 20140366218
    Abstract: The invention relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean Bowman-Birk type proteinase isoinhibitor gene (BBI3) and fragments thereof and their use in promoting the expression of one or more heterologous nucleotide sequences in an embryo-specific manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same.
    Type: Application
    Filed: September 13, 2012
    Publication date: December 11, 2014
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventor: Zhongsen Li
  • Publication number: 20140363844
    Abstract: An enzyme useful for producing cyclic peptides from linear peptide precursors and a gene encoding the enzyme are described. The enzyme is particularly useful for producing segetalins from linear presegetalin precursors. The linear presegetalin precursors may be derived from other linear presegetalin precursors farther upstream in the biosynthetic synthesis of the segetalin.
    Type: Application
    Filed: December 7, 2012
    Publication date: December 11, 2014
    Inventors: Carla Jann Siobhan Barber, Darwin Wilfred Reed, Janet Anne Condie, Sheila Diniwe Sherin Chiwocha, Patrick Smithers Covello
  • Publication number: 20140366226
    Abstract: The present invention relates generally to polysaccharide synthases. More particularly, the present invention relates to (1,3;1,4)-?-D-glucan synthases. The present invention provides, among other things, methods for influencing the level of (1,3;1,4)-?-D-glucan produced by a cell and nucleic acid and amino acid sequences which encode (1,3;1,4)-?-D-glucan synthases.
    Type: Application
    Filed: August 21, 2014
    Publication date: December 11, 2014
    Inventors: Rachel Anita Burton, Geoffrey Bruce Fincher, Antony Bacic
  • Publication number: 20140366223
    Abstract: This invention provides a method for generating transgenic plants with a low copy number. Plant cells are transformed with polynucleotides containing transcriptional cassettes designed to trigger silencing of a gene which is essential for the plant cell to survive the transformation and regeneration process. The present invention enables the recovery of an increased number of transgenic plants which have only one copy of each desired transcriptional cassette.
    Type: Application
    Filed: June 6, 2014
    Publication date: December 11, 2014
    Applicant: Syngenta Participations AG
    Inventors: Xianggan Li, Sivamani Elumalai
  • Publication number: 20140363422
    Abstract: Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.
    Type: Application
    Filed: January 2, 2013
    Publication date: December 11, 2014
    Inventors: Adrian Hayday, Kai Krohn, Annamari Ranki, Part Peterson, Kai Kisand, Edward Stuart, Annalisa MacAgno, Shimobi Onuoha
  • Publication number: 20140366220
    Abstract: A sugar cane plant cell comprising a recombinant nucleic acid molecule is provided, the recombinant nucleic acid molecule comprising a nucleotide sequence of interest, a promoter and the nucleotide sequence of SEQ ID NO:1, wherein the promoter is downstream of and in operative association with the nucleotide sequence of SEQ ID NO:1 and upstream of and in operative association with the nucleotide sequence of interest, and the nucleotide sequence of interest is expressed at a level at least about 6 times greater than the level of expression of said nucleotide sequence of interest in a control. Additionally, a method of increasing the expression of a nucleotide sequence of interest in a sugar cane plant cell using the recombinant nucleic acid molecule of the invention is provided.
    Type: Application
    Filed: December 7, 2012
    Publication date: December 11, 2014
    Applicants: Syngenta Participations AG, Queensland University of Technology
    Inventors: Mark D. Kinkema, Stacy Miles
  • Patent number: 8907173
    Abstract: The invention relates to the soybean variety designated A1035362. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1035362. Also provided by the invention are tissue cultures of the soybean variety A1035362 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1035362 with itself or another soybean variety and plants produced by such methods.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: December 9, 2014
    Assignee: Monsanto Technology LLC
    Inventor: Jennifer L. Yates
  • Patent number: 8907074
    Abstract: A laticiferous tissue-specific SRPP (small rubber particle-associated protein) promoter derived from Hevea brasiliensis, consists of nucleotide sequence of SEQ ID NO: 1. A recombinant plant expression vector includes the promoter. A plant is transformed with the recombinant plant expression vector and seed of the transformed plant is obtained. A method for laticiferous tissue-specific expression of a foreign gene in a transformed plant includes performing recombination of a foreign gene into the recombinant plant expression vector. The transformed plant produced by the method shows laticiferous tissue-specific expression of a foreign gene.
    Type: Grant
    Filed: October 10, 2011
    Date of Patent: December 9, 2014
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Beung Tae Ryu, Jeong Sheop Shin
  • Patent number: 8907172
    Abstract: The invention relates to the soybean variety designated A1035361. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1035361. Also provided by the invention are tissue cultures of the soybean variety A1035361 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1035361 with itself or another soybean variety and plants produced by such methods.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: December 9, 2014
    Assignee: Monsanto Technology LLC
    Inventor: Jennifer L. Yates
  • Patent number: 8907164
    Abstract: The invention provides coding and promoter sequences for a VS-1 and AP-2 gene, which affects the developmental process of senescence in plants. Vectors, transgenic plants, seeds, and host cells comprising heterologous VS-1 and AP-2 genes are also provided. Additionally provided are methods of altering nutrient allocation and composition in a plant using the VS-1 and AP-2 genes.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: December 9, 2014
    Assignee: The Samuel Roberts Noble Foundations, Inc.
    Inventors: Michael Udvardi, Jiading Yang, Eric Worley
  • Patent number: 8907171
    Abstract: The invention relates to the soybean variety designated A1035334. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1035334. Also provided by the invention are tissue cultures of the soybean variety A1035334 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1035334 with itself or another soybean variety and plants produced by such methods.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: December 9, 2014
    Assignee: Monsanto Technology LLC
    Inventor: Heinrich S. Wohleser
  • Patent number: 8907163
    Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these. The invention provides a plant comprising functional mammalian ?1,4-galactosyltransferase and mammalian sialyl transferase for producing complex N-linked glycans that are galactosylated and sialylated, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: December 9, 2014
    Assignee: Stichting Dienst Landbouwkundig Onderzoek
    Inventors: Hendrikus Antonius Cornelis Bakker, Hendrik Jan Bosch
  • Publication number: 20140356958
    Abstract: A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner.
    Type: Application
    Filed: June 30, 2014
    Publication date: December 4, 2014
    Inventors: Prashant G. MALI, George M. CHURCH, Luhan Yang
  • Publication number: 20140356959
    Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.
    Type: Application
    Filed: June 30, 2014
    Publication date: December 4, 2014
    Inventors: George M. CHURCH, Prashant G. MALI, Kevin M. ESVELT
  • Publication number: 20140356961
    Abstract: A method for generating a phased siRNA (phasiRNA) in a plant cell comprises introducing into the plant cell an effective amount of a microRNA (miRNA). A transcript of a NB-LRR encoding gene may be cleaved in the plant cell. Resistance of the plant to a microbe may be reduced. The plant may enter a symbiotic interaction with a microbe. Nodulation in the plant may be improved. Related compositions are provided.
    Type: Application
    Filed: July 20, 2012
    Publication date: December 4, 2014
    Applicant: University of Delaware Technology Park
    Inventors: Blake Meyers, Jixian Zhai, Janine Sherrier
  • Publication number: 20140359900
    Abstract: The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.
    Type: Application
    Filed: July 26, 2012
    Publication date: December 4, 2014
    Applicants: DSM IP ASSETS B.V., DOW AGROSCIENCES LLC
    Inventors: Terence A. Walsh, Daniel Gachotte, Ann Owens Merlo, Dayakar Reddy Pareddy, James Metz, Scott Bevan, Jerry Kuner
  • Publication number: 20140357487
    Abstract: The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing, at said site, a plant that comprises at least one nucleic acid comprising a nucleotide sequence encoding a wild-type hydroxyphenyl pyruvate dioxygenase or a mutated hydroxyphenyl pyruvate dioxygenase (mut-HPPD) which is resistant or tolerant to a coumarone-derivative herbicide and/or a nucleotide sequence encoding a wild-type homogentisate solanesyl transferase or a mutated homogentisate solanesyl transferase (mut-HST) which is resistant or tolerant to a coumarone-derivative herbicide, and applying to said site an effective amount of said herbicide. The invention further refers to plants comprising mut-HPPD, and methods of obtaining such plants.
    Type: Application
    Filed: October 30, 2012
    Publication date: December 4, 2014
    Applicant: BASF SE
    Inventors: Johannes Hutzler, Stefan Tresch, Thomas Mietzner, Matthias Witschel, Jens Lerchl, Raphael Aponte, Liliana Parra Rapado, Jill Marie Paulik
  • Publication number: 20140359899
    Abstract: The present invention relates to genetically modified plant cells that have altered expression or activity of at least one sucrose efflux transporter compared to levels of expression or activity of the at least one sucrose efflux transporter in an unmodified plant cell.
    Type: Application
    Filed: December 10, 2012
    Publication date: December 4, 2014
    Applicant: Carnegie Institution of Washington
    Inventor: Wolf B. Frommer