Involving Virus Or Bacteriophage Patents (Class 435/5)
  • Patent number: 11158397
    Abstract: The present invention relates to methods for evaluating and/or predicting the outcome of a clinical condition, such as cancer, metastasis, AIDS, autism, Alzheimer's, and/or Parkinson's disorder. The methods can also be used to monitor and track changes in a patient's DNA and/or RNA during and following a clinical treatment regime. The methods may also be used to evaluate protein and/or metabolite levels that correlate with such clinical conditions. The methods are also of use to ascertain the probability outcome for a patient's particular prognosis.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: October 26, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: John Zachary Sanborn, David Haussler
  • Patent number: 11155886
    Abstract: Methods for the rapid detection of the presence or absence of Zika virus in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting Zika virus and kits are provided that are designed for the detection of Zika virus.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: October 26, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Slav Dugenny, Ellen H Fiss, Jeffery Fong, Marintha Heil, Eugene Spier, Jingtao Sun
  • Patent number: 11156610
    Abstract: Described is a method for determining an analyte in a sample suspected to contain the analyte, by a) contacting the sample with a first and a second capture compound for the analyte, wherein the first and second capture compounds are non-identical capture compounds, and the capture compounds compete in binding to the analyte; b) contacting the capture compounds contacted with the sample with a specifier, wherein the specifier competes in binding to the capture compounds with the analyte; c) determining the amount of complexes having the specifier and a capture compound; and d) determining the analyte in a sample based on the result of step c). Also disclosed is a method for improving the specificity of an indirect immunoassay for determining an analyte, as well as kits, devices, and uses related to the methods.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: October 26, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Barbara Upmeier, Toralf Zarnt, Johannes Polz
  • Patent number: 11149296
    Abstract: Methods are provided for detecting antigen binding agents in samples. Aspects of the methods include detection of the aggregation of antigen binding agents with polynucleotide-bound antigens by sensitive proximity-based association of the antigen-bound polynucleotides. Aspects of the methods also include methods for the detection of such proximity-based association through nucleic acid amplification. In addition, compositions, e.g., reagents, kits, and devices, useful in practicing various embodiments of the methods are provided.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: October 19, 2021
    Assignee: the regents of the university of california
    Inventors: Peter Robinson, Cheng-Ting Tsai, Carolyn Bertozzi
  • Patent number: 11147887
    Abstract: The invention relates to nucleic acid constructs and gene therapy vectors that comprise an ATP7B variant for use in the treatment of conditions associated with a deficiency or dysfunction of Copper-transporting ATPase 2, and particularly of Wilson's disease. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases' levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: October 19, 2021
    Assignee: FUNDACIÓN PARA LA INVESTIGACIÓN MÈDICA APLICADA
    Inventors: Oihana Murillo Sauca, Gloria González Aseguinolaza, Rubén Hernández Alcoceba
  • Patent number: 11147467
    Abstract: An electromagnetic resonance-based disease detecting system may comprising a spectrum analyzer assembly comprised of one of a spectrum analyzer with an internal tracking generator or a spectrum analyzer with a separate signal generator, a radiating antenna electronically connected to the spectrum analyzer assembly output and configured to radiate a subject with an electromagnetic field based on a resonant frequency signal, wherein radiating a subject with the electromagnetic field generates a subject spectrum; a receiving antenna configured to receive the subject spectrum; a spectrum analyzer electronically connected to the receiving antenna and configured to receive the subject spectrum from the receiving antenna; and a processor, the processor being operatively connected to the spectrum analyzer assembly, the radiating antenna, the receiving antenna, and the spectrum analyzer, wherein the processor is configurable to store and control the resonant frequency signal generated by the spectrum analyzer assembly
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: October 19, 2021
    Assignee: ANAPOLE TECHNOLOGIES INC.
    Inventors: Stephen F. Botsford, Vitaly M. Seltser, Joseph F. Startari
  • Patent number: 11143655
    Abstract: Methods for obtaining a sample from a subject include providing a sample collection room within a retail store; and obtaining a sample from a subject at a retail location. Sample collection rooms may house a sample analysis device or system. Samples may be small, e.g., a finger-stick capillary blood sample.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: October 12, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Daniel Young, Chinmay Pangarkar
  • Patent number: 11137407
    Abstract: The invention provides a method of diagnosing arthritis or other joint degrading disease in a subject which comprises determining whether there is a presence or increase of lubricin having a joint tissue posttranslational modification, in a blood sample from the subject, the presence or increase of the lubricin having the joint tissue posttranslational modification indicating arthritis or other joint degrading disease in the subject. The invention further provides a kit or protocol for detecting arthritis or other joint degrading disease by detecting lubricin, the lubricin comprising a joint tissue posttranslational modification.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: October 5, 2021
    Assignee: Lynxon AB
    Inventors: Niclas Karlsson, Chunsheng Jin, Sebastian Kalamajski, Sarah Ann Flowers
  • Patent number: 11129885
    Abstract: As disclosed herein, the preS antigen on infectious hepatitis B virus (HBV) particles can provide B and T ceil epitopes that promote the humoral and cellular responses and enhance the seroprotection rate by overcoming non-responsiveness to the S antigen-only vaccines. Therefore, compositions and methods are disclosed using the preS antigen to develop vaccines and immune therapies for treating or preventing hepatitis B infection, in particular, virus-like particles (VLPs) are disclosed that contain the preS antigen on its surface. These VLPs can be used alone or in combination with vaccines containing the hepatitis B surface antigen (HBsAg) to vaccinate subjects against HBV as well as to activate T ceils for adoptive T cell therapy to eradicate HBV infected hapatocytes.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: September 28, 2021
    Assignees: Georgia State University Research Foundation, Inc., Peking University
    Inventors: Ming Luo, Xiaodan Cai
  • Patent number: 11133085
    Abstract: The present invention relates to methods for evaluating and/or predicting the outcome of a clinical condition, such as cancer, metastasis, AIDS, autism, Alzheimer's, and/or Parkinson's disorder. The methods can also be used to monitor and track changes in a patient's DNA and/or RNA during and following a clinical treatment regime. The methods may also be used to evaluate protein and/or metabolite levels that correlate with such clinical conditions. The methods are also of use to ascertain the probability outcome for a patient's particular prognosis.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: September 28, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: John Zachary Sanborn, David Haussler
  • Patent number: 11123730
    Abstract: A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. The fluidic centripetal device is adapted to be received within a rotatable holder. The apparatus comprises a fluidic component layer having fluidic features on at least a front face and a bottom component layer bonded to a rear of the fluidic component layer thereby creating a fluidic network through which the fluid flows under centripetal force. In one embodiment, the fluidic feature may be a bottom-Tillable chamber coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: September 21, 2021
    Assignees: Universite Laval, Meridian Bioscience Canada Inc.
    Inventors: Régis Peytavi, Sébastien Chapdelaine
  • Patent number: 11125749
    Abstract: A system for providing colorimetric and ratiometric comparison and quantification for medical test results, comprising a testing device including an alignment target and including a plurality of immunoassay test strips, the plurality of immunoassay test strips each including a test line and a control line, and a colorimetry device configured to operate with a mobile device, the mobile device including a camera and a software application stored thereon, wherein the software application provides executable instructions to detect color properties of a color of the test line and a color of a control line of at least one of the plurality of immunoassay test strips, determine a risk value for each of at least one disease risks tested using the biologic sample, wherein the risk value is a rating determined from the color properties of the color of the test line, and provide medical test results based on the risk value.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: September 21, 2021
    Assignee: Reliant Immune Diagnostics, Inc.
    Inventors: Jovan Hutton Pulitzer, Henry Joseph Legere, III
  • Patent number: 11119081
    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: September 14, 2021
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang
  • Patent number: 11112408
    Abstract: The present invention relates to a biosensor for detecting the presence and/or measuring the concentration of at least one biological agent, comprising a support on which a barcode is disposed, at least one area of which is functionalised by at least one aptamer capable of selectively immobilising said biological agent, said aptamer per se being directly or indirectly bonded to a pigment molecule capable either of producing colour, or of changing colour following the immobilisation of the biological agent by said aptamer.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: September 7, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE MONTPELLIER, AXLR, SATT DU LANGUEDOC ROUSSILLON (SATT AXLR)
    Inventors: Tatiana Rabe Ralam, Arnaud Vena, Mamadou Balde, Brice Sorli, Morgane Nedelec, Héla Bahloul
  • Patent number: 11111276
    Abstract: Isolated mutant dengue virus E protein variants are disclosed. The variant comprises an amino acid sequence that is at least 80% identical to SEQ ID NO: 1 and has one or more amino acid residue substitutions at position corresponding to Asn8 (N8), Arg9 (R9), Val12 (V 12) and/or Glu13 (E13). The variant may comprise an amino acid sequence that is at least 90% identical to the SEQ ID NO: 1 and lack an infection-enhancing antibody-binding motif comprising the amino acid sequence of SEQ ID NO: 28 at domain I. An isolated nucleic acid sequence encoding the variant, a plasmid expressing the variant, a plasmid expressing a virus-like particle comprising the variant, a DNA vaccine, and a method of detecting the presence of a dengue virus in a biological sample are also disclosed.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: September 7, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Han-Chung Wu, Chung-Tao Tang
  • Patent number: 11111507
    Abstract: The present disclosure is directed to methods of scarless genomic engineering in microorganisms, such as Bacillus, and provides for new molecular tools and methods which enable scarless genetic editing using at least one counterselectable marker that has been codon optimized for the microorganism. The disclosure allows for the high-throughput introduction of stable genetic edits to a genome using either plasmid or linear DNA constructs for genetic engineering.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: September 7, 2021
    Assignee: Zymergen Inc.
    Inventors: Tara F. Mahoney, Amanda Renae Reider Apel, Paloma Rueda Romero
  • Patent number: 11111520
    Abstract: This disclosure provides methods and compositions that are useful for enriching a particular population of nucleic acids (a “population of interest”) within a complex mixture of nucleic acids. The population of interest may make up a minor portion of a complex mixture of nucleic acids. The methods and compositions provided herein are useful for detecting, predicting, diagnosing, or monitoring a disease or disorder, particularly a disease or disorder caused by a foreign microbe or pathogen.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: September 7, 2021
    Assignee: Karius, Inc.
    Inventors: Timothy A. Blauwkamp, Fred Christians, Igor D. Vilfan, Scott Smith, Michael Kertesz
  • Patent number: 11112405
    Abstract: Assay devices, systems, methods, and kits useful for detection of analytes in a bodily fluid sample, such as saliva, are disclosed herein. Assay devices may include a fluid sample collector and an assessment unit to which the fluid sample collector couples. The fluid sample collector may include a cap with a plunger and absorbent member that collects a bodily fluid sample. Insertion of the plunger into the assessment unit during coupling provides pressure-driven fluid flow through a filter rapidly delivering bodily fluid filtrate to one or more test panels which provide the assay result. In embodiments, an on-board light source enables a user to readily detect changes in a test panel indicative of the presence of an analyte thus providing an opportunity for obtaining rapid results with improved confidence.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: September 7, 2021
    Assignee: Baseline Global, Inc.
    Inventors: Balwant Rai, Jeffery Floyd McAllister, Peter Andrew Smith, Jay Colton Zignego, Michael Eugene O'Donnell, Leonard Kristal, Matthew Hon Ming Kwok, Mark Kin Ming Kwok
  • Patent number: 11104948
    Abstract: The present invention relates to controls for NGS methods. The present application discloses plasmids, kits, their uses and methods involving the controls according to the present invention.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: August 31, 2021
    Assignee: VELA OPERATIONS SINGAPORE PTE. LTD.
    Inventor: Mengchu Wu
  • Patent number: 11099004
    Abstract: A method of marking a hydrated tissue specimen for mechanical testing is provided. The method includes adding a metal nanoparticle precursor solution to a reducing agent solution to form a mixture; incubating the mixture to form a plurality of aggregated metal nanoparticles, where each of the aggregated metal nanoparticles includes a plurality of individual metal nanoparticles; separating the plurality of aggregated metal nanoparticles from a supernatant by means of centrifugation or gravitational settling; resuspending the plurality of aggregated metal nanoparticles in a buffer solution to form a colloidal metal nanoparticle suspension; and soaking the hydrated tissue specimen in the colloidal metal nanoparticle suspension, where at least a portion of the plurality of aggregated metal nanoparticles adhere to the hydrated tissue specimen in a random pattern of speckles.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: August 24, 2021
    Assignee: University of South Carolina
    Inventors: Susan M. Lessner, Liya Du
  • Patent number: 11097266
    Abstract: The present invention provides an apparatus for detecting the presence or absence of an analyte in samples, comprising: a collection chamber for receiving liquid sample, comprising an opening; a testing element for testing the analyte in liquid sample; and a cover body for covering the opening of the collection chamber; wherein the apparatus further comprises a prompting device for prompting if the cover body is covered to a specified location, the prompting device gives prompt by making a sound, wherein the prompting device comprises a non-elastic element and an elastic element, the non-elastic element is located on the collection chamber, the elastic element is located on the cover body, the elastic element is a part of the cover body. It is easy to perform detection using this apparatus, with low processing cost.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: August 24, 2021
    Assignee: HANGZHOU BIOTEST BIOTECH CO., LTD.
    Inventor: Kefeng Zhang
  • Patent number: 11092594
    Abstract: A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, athiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: August 17, 2021
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Jerome W. Kosmeder, II, Mark Lefever, Donald Johnson, Michael Farrell, Zhanna Zhilina, Christopher Bieniarz
  • Patent number: 11091791
    Abstract: Provided herein are compositions, methods, and kits for enriching for one or more nucleic acid sequences of interest in a sample. The methods include providing a circular ligase, one or more 5? hook probes and/or one or more 3? hook probes and contacting the sample comprising the nucleic acids with the circular ligase and one or more 5? hook probes and/or one or more 3? hook probes under conditions to allow the hook probes to selectively bind to the one or more nucleic acid sequences of interest, and under conditions to form one or more hook products, each hook product comprising the hook probes and the one or more nucleic acid sequences of interest.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: August 17, 2021
    Assignee: MGI Tech Co., Ltd.
    Inventors: Yuan Jiang, Radoje Drmanac
  • Patent number: 11092600
    Abstract: A method for detecting at least one microorganism that may be present in a sample, comprising the steps of: a) bringing into contact, in a container: a culture medium that enables the growth and/or detection of microorganisms, said sample and a sensitized solid support; b) subjecting the whole to a temperature that promotes the growth and/or detection of microorganisms; and c) observing, in real time, the appearance of an agglutination indicating the presence of the microorganism(s) or confirming said presence when said microorganisms are detected in said culture medium, when step b) has been completed, and a method for detecting and identifying at least one target microorganism that may be present in a sample.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: August 17, 2021
    Assignee: BIOMERIEUX
    Inventors: Bruno Colin, David Mosticone, Jean-Claude Raymond, Thierry Sofia, Antoine Vimont
  • Patent number: 11090650
    Abstract: A method for manufacturing a test element for detecting at least one analyte in a body fluid, a test element for detecting at least one analyte in a body fluid, a method for detecting at least one analyte in a body fluid, a system for detecting at least one analyte in a body fluid and a method for manufacturing a test element for detecting at least one analyte in a body fluid are disclosed.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: August 17, 2021
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Joerg Dreibholz, Volker Hullen, Maria Dambach, Herbert Fink, Daniela Pfiffi, Bernd Hiller, Carina Horn
  • Patent number: 11085911
    Abstract: Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: August 10, 2021
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Daniel Levner, Christopher David Hinojosa, Andries D. van der Meer, Marinke van der Helm, Abhishek Jain, Donald Elliot Ingber, Marjon Zamani
  • Patent number: 11085072
    Abstract: The present disclosure provides a number of targeted nucleic acid FISSEQ library construction methods. Targeted FISSEQ can exhibit several benefits, such as enhanced sensitivity and/or shorter assay time in the detection, identification, quantification, and/or determining the nucleotide sequence of the target species, relative to “random” or “whole-omic” detection via FISSEQ.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: August 10, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Evan R. Daugharthy, Richard C. Terry, Benjamin W. Pruitt, Brian M. Turczyk
  • Patent number: 11085922
    Abstract: A method for detecting and quantifying anti-neutrophil-cytoplasmic antibodies (ANCA) in a sample of bodily fluid from a patient suspected of suffering from an autoimmune disease, including the steps of contacting human polymorphonuclear neutrophils able to release extracellular traps (NETs) with microspheres to produce NET-coated microspheres, contacting the NET-coated microspheres with the sample of bodily fluid, and labeling and subsequent analyzing of anti-neutrophil-cytoplasmic antibodies by flow cytometric methods.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: August 10, 2021
    Assignee: Immundiagnostik AG
    Inventors: Franz Paul Armbruster, Moritz Leppkes
  • Patent number: 11079386
    Abstract: The present invention relates to monoclonal antibodies against FZD10. Furthermore, the present invention provides methods for diagnosing FZD10-related diseases using such an antibody, methods for detecting a FZD10 protein, methods for determining drug efficacy after treatment with FZD10 inhibitors, and methods of screening for subjects in whom treatment with FZD10 inhibitors is highly effective, and provides diagnostic reagents containing such an antibody.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: August 3, 2021
    Assignee: ONCOTHERAPY SCIENCE, INC.
    Inventors: Yosuke Harada, Tatsuki Yokoseki, Yusuke Nakamura
  • Patent number: 11081703
    Abstract: A method of preparing a catalyst for a fuel cell includes no carbon support. The method of preparing a catalyst for a fuel cell includes preparing a first metal nanoparticle having a polyhedral shape, growing a second metal along the edge of the first metal nanoparticle, and removing the first metal nanoparticle.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: August 3, 2021
    Assignees: HYUNDAI MOTOR COMPANY, KIA MOTORS CORPORATION, RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
    Inventors: Ju Ahn Park, Sung Ho Park
  • Patent number: 11075010
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media for pharmacology model optimization based on distributed data acquisition. A computer system stores a first pharmacology model associated with a drug dosage model for a particular medication. The computer system receives patient data including pharmacological data and data values for a drug identifier and a pharmacology model identifier. The pharmacological data being associated to drug dosing for the particular medication. The computer system aggregates the received data into a first data set based on the drug identifier value. The computer system optimizes the first pharmacology model using the first data set, thereby generating a second pharmacology model. The computer system provides access to the optimized second pharmacology model.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: July 27, 2021
    Assignee: Insight RX, Inc.
    Inventors: Srijib Goswami, Ron Keizer, Ranvir Mangat
  • Patent number: 11067493
    Abstract: A particle measuring method, a sample processing method, and a particle imaging apparatus capable of efficiently acquiring information effective in pathological diagnosis or the like are provided. The particle measuring method comprises a step (S13) of labeling and amplifying, within a particle, a target nucleic acid in the particle, a step (S14) of labeling a surface target polypeptide on the surface of the particle and/or target nucleic acid different from the first target nucleic acid, and a step (S2) of measuring the labeled target nucleic acid and the labeled target polypeptide and/or other labeled target nucleic acid.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: July 20, 2021
    Assignee: SYSMEX CORPORATION
    Inventors: Takanori Maekawa, Yusuke Konishi
  • Patent number: 11066707
    Abstract: The present invention relates to highly sensitive and specific methods for detection of nucleic acids, which for example are useful for detection of rare mutations, or for detection of low-abundance variants in nucleic acids sequences. The methods involve an asymmetric incremental polymerase reaction (AIPR) followed by an exponential polymerase chain reaction (PCR).
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: July 20, 2021
    Assignee: SAGA DIAGNOSTICS AB
    Inventors: Anthony Miles George, Lao Hayamizu Saal
  • Patent number: 11060670
    Abstract: A grille lighting system includes a light emitting lamp that includes one or more walls defining an inner space isolated from outside, a light emitting material disposed in the inner space and configured to emit light when the light emitting material contacts air, and a shutter disposed on the one or more walls, wherein the shutter is configured to be opened to allow introduction of outside air to the inner space from outside and further configured to be closed to block introduction of outside air to the inner space. The system further includes a controller configured to control operation of the shutter and cause the shutter to be opened and closed such that when the shutter is opened, the outside air is introduced to contact the light emitting material, which causes the light emitting material to emit light.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: July 13, 2021
    Assignees: Hyundai Motor Company, Kia Motors Corporation
    Inventor: Gyu-Bong Kim
  • Patent number: 11061026
    Abstract: Disclosed herein are devices, systems, methods and kits for performing immunoassay tests to detect for at least progesterone or analytes of progesterone on a sample in association with diagnosing problems and issues associated with corpus luteum functionality. The immunoassay devices and methods may be used in conjunction with diagnostic reader systems and/or a base unit for obtaining a sensitive read-out of the immunoassay results. The immunoassay devices and methods may utilize a competitive binding-like assay and a sandwich binding assay to detect at least progesterone or analytes of progesterone in a sample.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: July 13, 2021
    Assignee: MFB Fertility, Inc.
    Inventor: Amy Beckley
  • Patent number: 11058766
    Abstract: The disclosure relates to vaccination compositions, for example, against human papillomavirus, Zika virus, and flu virus. The disclosure also relates to vectors for producing the virus-like particles and immune complex platforms of the vaccination compositions.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: July 13, 2021
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Hugh Mason, Andrew Diamos, Mary Pardhe, Brandon Favre
  • Patent number: 11053531
    Abstract: In various embodiments, the present disclosure provides testers for detecting a bacterial infection and methods of production and uses thereof.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: July 6, 2021
    Inventor: Linda Marie Petter
  • Patent number: 11047869
    Abstract: The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a tissue sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis. Due to the use of a liquid phase that does not destroy native tissue morphology during analysis, a subsequent staining technique can be performed on the tissue sample and an overlaid image can be produced of a mass spectral image and a staining image.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: June 29, 2021
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Livia Schiavinato Eberlin, Christina Ramires Ferreira, Allison Lisa Dill, Demian R. Ifa
  • Patent number: 11046986
    Abstract: A method for producing RNA is provided. Objective RNA is produced by culturing a coryneform bacterium having an expression unit for the objective RNA, which has been modified so that the activity of ribonuclease III is reduced, in a medium, to express the objective RNA and accumulate the objective RNA in cells of the bacterium, and collecting the objective RNA from the cells.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: June 29, 2021
    Assignee: AJINOMOTO CO., INC.
    Inventors: Shuhei Hashiro, Hisashi Yasueda, Mayu Mitsuhashi, Sergei Vladimirovich Mashko, Aleksandr Aleksandrovich Krylov, Yuliya Sergeevna Lobanova
  • Patent number: 11041855
    Abstract: The disclosure relates to wireless detection of analytes (such as bacteria) labeled by electrically, dielectrically, or magnetically active nanoparticles, for example in quality control monitoring for food supply chain management. The disclosed apparatus includes a detection vessel or vial, a resonant sensor tag, an inductively coupled reader to induce and detect resonance in the sensor tag, and an active nanoparticle for labeling. The disclosed wireless detection apparatus and methods use active nanoparticles for the development of wireless sensor systems which can be designed to be compatible with the existing RFID technology infrastructure. For example, commercial RFID readers (e.g., hand-held) used for tracking and tracing operation can be used with the disclosed apparatus to induce and measure a corresponding resonance frequency.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: June 22, 2021
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Premjeet Chahal, Evangelyn C. Alocilja, Saranraj Karuppuswami, Leann Lerie Matta
  • Patent number: 11043304
    Abstract: Systems and methods are provided for training a classifier to discriminate between a first cancer condition associated with an oncogenic pathogenic infection a second cancer condition that is not associated with an oncogenic pathogenic infection. Systems and methods are provided for distinguishing cancers associated with oncogenic pathogenic infections that contribute to the cancer pathology and cancers that are not associated with oncogenic pathogenic infections. Systems and methods are provided for treating cancer based on whether the cancer is associated with an oncogenic pathogenic infection.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: June 22, 2021
    Assignee: Tempus Labs, Inc.
    Inventors: Ariane Lozac'hmeur, Denise Lau, Aly A. Khan
  • Patent number: 11041850
    Abstract: Methods are provided for detecting a glycosylated target protein in a sample. Aspects of the methods include: (a) contacting a sample comprising a probe-labeled glycosylated target protein with: (i) a first conjugate comprising a first nucleic acid tag linked to a first capture agent that specifically binds the target protein; (ii) a second conjugate comprising a second nucleic acid tag linked to a second capture agent that specifically binds the probe; and (iii) a bridging nucleic acid that hybridizes to the first and second nucleic acid tags; under conditions sufficient to specifically bind the first and second capture agents to the probe-labeled target protein and to hybridize the bridging nucleic acid to the first and second nucleic acid tags to produce a nucleic acid complex; and (b) detecting the nucleic acid complex. Also provided are compositions and kits useful in practicing various embodiments of the subject methods.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: June 22, 2021
    Assignee: The Regents of the University of California
    Inventors: Carolyn R. Bertozzi, Peter V. Robinson, Cheng-Ting Tsai
  • Patent number: 11037694
    Abstract: Highly uniform and thin silver nanowires are described having average diameters below 20 nm and a small standard deviation of the diameters. The silver nanowires have a high aspect ratio. The silver nanowires can be characterized by a small number of nanowires having a diameter greater than 18 nm as well as with a blue shifted narrow absorption spectrum in a dilute solution. Methods are described to allow for the synthesis of the narrow uniform silver nanowires. Transparent conductive films formed from the thin, uniform silver nanowires can have very low levels of haze and low values of ?L*, the diffusive luminosity, such that the transparent conductive films can provide little alteration of the appearance of a black background.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: June 15, 2021
    Assignee: C3 Nano, Inc.
    Inventors: Yongxing Hu, Ying-Syi Li, Xiqiang Yang, Jing Shun Ang, Ajay Virkar
  • Patent number: 11035012
    Abstract: The invention provides chimeric capture probes immobilizable via an L-nucleic acid tail that can bind to a complementary L-nucleic acid in an immobilized probe. The capture probes are useful for capturing a target nucleic acid from a sample. The L-nucleic acid in the tail of the capture probe bind to the complementary L-nucleic acid in the immobilized probe with similar affinity as would otherwise equivalent D-nucleic acids. However, the L-nucleic acid of the capture probe tail and immobilized probes do not form stable duplexes with D-nucleic acids present in the in the sample containing the target nucleic acid. Binding of nucleic acids in the sample directly to immobilized probe or to the tail of the capture probe is reduced or eliminated increasing the sensitivity and/or specificity of the assay.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: June 15, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Reinhold Pollner, Mehrdad Majlessi, Susan Yamagata, Michael M. Becker, Mark Reynolds, Lyle Arnold
  • Patent number: 11026408
    Abstract: The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: June 8, 2021
    Assignees: Regeneron Pharmaceuticals, Inc., Yale University, Institute for Research in Biomedicine (IRB)
    Inventors: Richard Flavell, Markus Manz, Anthony Rongvaux, Till Strowig, Tim Willinger, Andrew J. Murphy, Sean Stevens, George Yancopoulos
  • Patent number: 11028450
    Abstract: The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or more lactobacilli and two or more pathogenic organisms may be detected using PCR analysis of nucleic acid segments corresponding to each target organism. The quantity of the target organisms can then be used to determine a score which is indicative of a diagnosis of bacterial vaginosis.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: June 8, 2021
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Erik P. Johnson, Dale A. Schwab
  • Patent number: 11021700
    Abstract: The invention relates to methods of purifying viral vectors from cell culture. In particular, the invention relates to a method of purifying a supernatant containing viral vectors from a cell culture by removing cells by filtering the cell culture using diatomaceous earth.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: June 1, 2021
    Assignee: SARTORIUS LAB INSTRUMENTS GMBH & CO. KG
    Inventors: Paul Stephen Carter, Sara Margareta Nilsson
  • Patent number: 11014948
    Abstract: The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II): processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: May 25, 2021
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, Hong Kong Polytechnic University
    Inventors: Masad J. Damha, Matthew Hassler, Tak-Hang Chan, Mallikarjuna Reddy Nandyala, Robert Alexander Donga
  • Patent number: 11015189
    Abstract: Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a library from which the capsids are selected are also provided.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: May 25, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Leszek Lisowski, Mark A. Kay
  • Patent number: RE48665
    Abstract: Method, composition, kit and system for isolating amplifiable nucleic acid from specimens preserved in a liquid-based cytology preservative that contains formaldehyde. The technique relies on the use of 2-imidazolidone and a protease enzyme, such as proteinase K, at elevated temperatures. Advantageously, RNA can be isolated and used as a template in nucleic acid amplification reactions.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: August 3, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Deborah C. Jensen, Brett W. Kirkconnell, Timothy J. Wilson