Involving Virus Or Bacteriophage Patents (Class 435/5)
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Patent number: 11926861Abstract: The invention describes a method for determining how to stimulate, monitor and/or inhibit virus production in whole blood culture. The invention relates to a test kit for performing the method and to the use of a suitable blood sampling system. The system can be used to determine how to activate or target latently HIV-infected cells, for clinical management of HIV treatments and for personalized therapeutic strategies.Type: GrantFiled: February 3, 2020Date of Patent: March 12, 2024Inventor: Heidi Kay
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Patent number: 11919971Abstract: This disclosure provides, e.g., methods for coupling Formation of Surface Carboxylates on PES an entity to a solid substrate. The method can comprise treating the with Exposure Time substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.Type: GrantFiled: May 16, 2017Date of Patent: March 5, 2024Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Daniel Christopher Leslie, Thomas Doyle, Anna Waterhouse, Melissa Rodas, Alexander L. Watters, Michael Super, Donald E. Ingber
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Patent number: 11920168Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having nuclease grafted to one or more capsid proteins. In some aspects, the disclosure relates to isolated AA V capsid proteins having terminally grafted nucleases and isolated nucleic acids encoding the same. Recent approaches to delivering nucleases to cells for gene editing have focused on delivering of expression vectors engineered to express the nucleases in target cells. However, these approaches have proved to be problematic in many instances due to genotoxicity resulting from to prolonged expression of gene editing system in vivo. To prevent such off-target genotoxicity due to prolonged presence of a gene editing system, several studies explored delivery of mRNA or protein instead of delivering the gene coding for the nucleases in cell culture.Type: GrantFiled: January 29, 2020Date of Patent: March 5, 2024Assignee: University of MassachusettsInventors: Guangping Gao, Phillip D. Zamore, Dan Wang
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Patent number: 11913082Abstract: Methods are provided for a sensitive and specific assay for the determination of viral load and genotyping of RSV in a biological sample. Compositions and kits for use in the methods also are provided, including optimized primers for the amplification of and detection of the RSV open reading frames from subtypes A and B, and probes for distinguishing between the subtypes. Also provided are methods for amplifying and sequencing an open reading from of an RSV F protein, and compositions and kits for use in the methods.Type: GrantFiled: June 22, 2020Date of Patent: February 27, 2024Assignee: Laboratory Corporation of America HoldingsInventor: Justin Philip De La Cruz
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Patent number: 11906515Abstract: A multiplexed lateral flow device includes an impermeable internal reservoir having an opening to receive a sample deposition. A fluid distributor pad is arranged in fluid communication with a lower surface of the internal reservoir. The fluid distributor pad includes a paper based microfluidic element having a pattern of a hydrophobic material to distribute a portion of the sample deposition substantially equally among a plurality of flow paths. Lateral flow assays having a plurality of flow lines are aligned with flow paths of the distributor pad. An impermeable top cover has a first window arranged over the opening of the internal reservoir, and at least a second window arranged over the test results of the lateral flow assays. A housing element houses the reservoir, the distributor pad and lateral flow assays.Type: GrantFiled: April 9, 2020Date of Patent: February 20, 2024Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, FUNDACAO OSWALDO CRUZInventors: Jaione Tirapu Azpiroz, Ademir Ferreira da Silva, Matheus Esteves Ferreira, Ricardo Luis Ohta, Mathias B. Steiner, Antonio Gomes Pinto Ferreira, Edimilson Domingos da Silva, Nara Mazarakis Rubim, Pedro Paulo Ferreira Ribeiro
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Patent number: 11908140Abstract: Disclosed is a method and system for identifying a protein domain based on a protein three-dimensional structure image. According to the present application, the protein domain is identified based on a structure similarity, the identification errors and omissions of the protein domain caused by protein multi-sequence alignment errors when sequence consistency is not high can be effectively solved. According to the present application, the point cloud segmentation model based on the dynamic graph convolutional neural network is constructed, and by integrating global structural features and local structural features, segmentation of the protein domain and acquisition of semantic labels of the protein domain can be completed at the same time.Type: GrantFiled: August 2, 2023Date of Patent: February 20, 2024Assignee: ZHEJIANG LABInventors: Jingsong Li, Jing Ma, Yu Wang
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Patent number: 11898201Abstract: Methods and compositions are provided for improved nucleic acid amplification assays. In some embodiments, the nucleic acid amplification assay is a tagged amplicon primer extension (TAPE) nucleic acid amplification reaction.Type: GrantFiled: January 13, 2021Date of Patent: February 13, 2024Assignee: Bio-Rad Laboratories, Inc.Inventors: Nicholas Heredia, Dianna Maar
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Patent number: 11891656Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.Type: GrantFiled: June 14, 2022Date of Patent: February 6, 2024Assignee: Singular Genomics Systems, Inc.Inventors: Eli N. Glezer, Hu Cang, Zhenmin Hong
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Patent number: 11890826Abstract: A method of enhancing a footwear impression formed on a porous surface using a potassium ferrocyanide solution for footwear impression enhancement includes: forming a porous surface sample by leaving footwear impressions into an object having a porous surface; preparing a potassium ferrocyanide solution for footwear impression enhancement; and applying the potassium ferrocyanide solution for footwear impression enhancement to the porous surface sample.Type: GrantFiled: August 26, 2022Date of Patent: February 6, 2024Assignee: REPUBLIC OF KOREA (NATIONAL FORENSIC SERVICE DIRECTOR MINISTRY OF THE INTERIOR AND SAFETY)Inventors: Nam Kyu Park, Byung Seon Moon, Jae Mo Goh, Jin Pyo Kim, Young Il Seo, Eun Ah Joo, Je Hyun Lee, Yong Jun Kim
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Patent number: 11887830Abstract: A method and apparatus for monitoring and/or controlling the extent of denaturation and/or bond cleavages of proteins on any surface (e.g., biological tissues, biofilms, etc.). In one embodiment, a low power laser (e.g., a 5 mW, 362 nm diode laser) is directed through a biological sample to a photodetector. The sample is heated by a set of radiant heaters to between about 220° C. and about 250° C. in a time period of between 10 seconds to 60 seconds. The baseline transmissivity of the sample is monitored continuously throughout treatment of the biological sample via continuous monitoring of the signal voltage detected at the photodetector. Upon detection of increase in relative transmissivity in the biological sample, the heating treatment is concluded and the biological sample is removed for in situ protein identification as part of an imaging MALDI-MS measurement.Type: GrantFiled: December 20, 2021Date of Patent: January 30, 2024Assignee: UNIVERSITY OF WYOMINGInventors: Erica Belmont, Franco Basile, James Rundel, Andrew Goodenough
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Patent number: 11857619Abstract: Described herein is a process for protein purification, particularly a process for the purification of a glycoprotein, such as an HIV envelope protein, useful for vaccines or biotherapeutics.Type: GrantFiled: November 6, 2020Date of Patent: January 2, 2024Assignee: Janssen Vaccines & Prevention B.V.Inventors: Christopher Rode, Brian Polilli, John Schreffler
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Patent number: 11852968Abstract: To provide a pellicle in which outgas from an adhesive layer is suppressed. The pellicle includes a pellicle film, a support frame for supporting the pellicle film, a protrusion part arranged in the support frame, a first adhesive layer arranged on the protrusion part; and an inorganic material layer arranged at a position closer to the pellicle film than the first adhesive layer. The inorganic material layer may include a first inorganic material layer arranged at a first side surface of the first adhesive layer, the first side surface of the first adhesive layer intersecting the pellicle film, and arranged at a position closer to the pellicle film.Type: GrantFiled: September 3, 2020Date of Patent: December 26, 2023Assignee: MITSUI CHEMICALS, INC.Inventors: Yosuke Ono, Kazuo Kohmura, Atsushi Okubo, Daiki Taneichi, Hisako Ishikawa, Tsuneaki Biyajima
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Patent number: 11851701Abstract: A probe comprising a reporter region for detecting a first single nucleotide polymorphism, an anchor region for detecting a second single nucleotide polymorphism, and a linker region is disclosed. The reporter region comprises an oligonucleotide consisting of a sequence perfectly matching with the first target sequence, and a fluorescent dye that quenches when hybridized to the first target sequence where the first single nucleotide polymorphism is present. The anchor region comprises an oligonucleotide consisting of a sequence perfectly matching with a second target sequence where the second single nucleotide polymorphism is present. A length of the oligonucleotide of the reporter region is shorter than a length of the oligonucleotide of the anchor region.Type: GrantFiled: March 12, 2019Date of Patent: December 26, 2023Assignee: EIKEN KAGAKU KABUSHIKI KAISHAInventor: Atsuka Matsui
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Patent number: 11845958Abstract: Genetically modified CCNT1 and XPO1 genes encoding proteins that inhibit virus infection in cells. The genetically modified CCNT1 gene encodes a protein with a C261Y substitution with respect to the human CCNT1 protein. The genetically modified XPO1 gene encodes a protein with P411T, M412V, and/or F414S substitutions with respect to the human XPO1 protein. The genetically modified CCNT1 and XPO1 genes can be introduced in cells. The cells comprising the genetically modified CCNT1 and XPO1 genes can be introduced in a subject with a virus infection to treat the infection.Type: GrantFiled: September 5, 2019Date of Patent: December 19, 2023Assignee: Wisconsin Alumni Research FoundationInventors: Nathan Mark Sherer, Ryan Thomas Behrens
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Patent number: 11839605Abstract: A non-injectable formulation or formulation for instillation, including self-assembling hydrogels formed of gelators such as the Food and Drug Administration's Generally Regarded as Safe (GRAS) compounds like ascorbyl palmitate, in the form of capsules, tablets, oral suspensions, enemas, and rectal or vaginal suppositories or inserts have been developed. In a preferred embodiment, the formulation contains anti-inflammatories, anti-infectives, or other therapeutic, prophylactic, or diagnostic agents that can be administered orally, especially when lower blood levels relative to tissue levels of agent are preferred. In the most preferred formulation, the composition contains tacrolimus-loaded ascorbyl palmitate gel microfibers containing nanostructures (“hydrogels”).Type: GrantFiled: September 10, 2019Date of Patent: December 12, 2023Assignee: Alivio Therapeutics, Inc.Inventors: Derek G. Van der Poll, Dominick J. Blasioli, Gregory T. Zugates
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Patent number: 11841310Abstract: In one example, a flow cell includes a substrate, an electrode positioned on the substrate, and a patterned material positioned on the electrode. In this example, the patterned material includes depressions separated by interstitial regions, and a functionalized surface of the electrode is exposed at each of the depressions. In this example, the flow cell further includes a primer grafted to the functionalized surface in each of the depressions. In another example, a flow cell includes a substrate and a patterned electrode positioned on the substrate. In this other example, the patterned electrode includes depressions separated by interstitial regions, and a functionalized surface of the substrate exposed at each of the depressions. In this other example, a primer is grafted to the functionalized surface in each of the depressions.Type: GrantFiled: December 3, 2019Date of Patent: December 12, 2023Assignee: Illumina, Inc.Inventors: Hayden Black, Brian D. Mather
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Patent number: 11838873Abstract: Systems, methods, apparatuses, and computer program products for altitude-aware energy saving. The method may include receiving, from a network element, information including a coupling loss change or a reduced transmit power command. The method may also include controlling an uplink transmission based on the received information.Type: GrantFiled: April 15, 2021Date of Patent: December 5, 2023Assignee: NOKIA TECHNOLOGIES OYInventors: Gilsoo Lee, Rapeepat Ratasuk, Tzu-Chung Hsieh, Shahzada Basharat Rasool, Athul Prasad
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Patent number: 11830190Abstract: Techniques are for detecting presence of a problematic cellular entity in a target. In an example, using an analysis model, a fluorescence-based image is analyzed. The analysis model is trained using a number of reference fluorescence-based images for detecting the presence of problematic cellular entities in targets. Based on the analysis, a problematic cellular entity present in the target is detected. To perform the detection, the analysis model is trained to differentiate between the fluorescence in the fluorescence-based image emerging from the problematic cellular entity and the fluorescence in the fluorescence-based image emerging from regions other than the problematic cellular entity.Type: GrantFiled: May 27, 2022Date of Patent: November 28, 2023Assignee: ADIUVO DIAGNOSTICS PRIVATE LIMITEDInventors: Bala Pesala, Geethanjali Radhakrishnan, Bikki Kumar Sha, John King
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Patent number: 11828654Abstract: A spectroscopic analyzer includes: an irradiator that irradiates a target measurement object with lights of a plurality of different wavelengths sequentially as a pre-irradiation, and, after the pre-irradiation, further irradiates the target measurement object with lights of a plurality of different wavelengths sequentially as a measurement-irradiation; a detector that, during the measurement-irradiation, detects reflected light, transmitted light, or a transmitted reflected light from the target measurement object at each of the plurality of different wavelengths of the measurement-irradiation and that outputs absorbance spectral data; a data analyzer that analyzes the absorbance spectral data; and a result display that displays analysis results related to components of the target measurement object.Type: GrantFiled: September 18, 2019Date of Patent: November 28, 2023Inventor: Roumiana Tsenkova
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Patent number: 11821899Abstract: Indirect ELISAs to detect exposure to Felis catus gammaherpesvirus 1 (FcaGHV1) in domestic cats. These ELISAs detect feline serum antibodies to ORF52 and ORF38 of FcaGHV1. The ELISA assays are sensitive, specific, and adaptable for scale up use in high throughput diagnostics.Type: GrantFiled: July 19, 2018Date of Patent: November 21, 2023Assignee: Colorado State University Research FoundationInventors: Susan VandeWoude, Kathryn R. Stutzman-Rodriguez, Ryan M. Troyer
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Patent number: 11808700Abstract: Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.Type: GrantFiled: June 14, 2019Date of Patent: November 7, 2023Assignee: Quantum-Si IncorporatedInventors: Jonathan M. Rothberg, Benjamin Cipriany, Faisal R. Ahmad, Joseph D. Clark, Daniel B. Frier, Michael Ferrigno, Mel Davey, Tom Thurston, Brett J. Gyarfas, Todd Rearick, Jeremy Christopher Jordan
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Patent number: 11808688Abstract: The present relates to a measurement device (1) for the detection and/or measurement of particles in a fluid, the measurement device comprising a fluid source (11) for producing a flow of fluid (111) along a fluid flow path, a first laser source (12) positioned for emitting a first laser beam (120) of laser light in a measurement volume of the fluid flow path for light scattering; a scattered light detecting means (13) for detecting a presence of a particle in the fluid flow path through detection and measurement of laser beam light scattered on different angles by said particle, wherein it further comprises a second laser source (14) positioned for emitting a second laser beam (140) of laser light in said measurement volume of the fluid flow path for Raman and fluorescence excitation; a Raman and fluorescence detecting means (15) for detecting a Raman scattering signal emitted by the fluid and a Fluorescence signal emitted by said particle upon excitation by said second laser beam (140).Type: GrantFiled: October 25, 2018Date of Patent: November 7, 2023Assignee: Plair, SAInventors: Denis Kiselev, Fabio Capela
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Patent number: 11802305Abstract: A process for analysing epigenetically active regions of the genome.Type: GrantFiled: June 24, 2016Date of Patent: October 31, 2023Assignee: Oxford Biodynamics PLCInventors: Alexandre Akoulitchev, Ewan Hunter, Aroul Ramadass
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Patent number: 11801257Abstract: A composition and method for activating immune cells ex-vivo, or inducing an immune response in a subject including a composition comprising at least one chiral cationic lipid. The chiral cationic lipid in one embodiment comprises a nonsteroidal cationic lipid having a structure represented by formula (I); wherein in R1 is a quaternary ammonium group, Y1 is a space chosen from a hydrocarbon chain, an ester, a ketone, and a peptide, C* is a chiral carbon, R2 and R3 are independently chosen from a saturated fatty acid, an unsaturated fatty acid, an ester-linked hydrocarbon, phosphor-diesters, and combination thereof.Type: GrantFiled: June 12, 2020Date of Patent: October 31, 2023Assignee: PDS BIOTECHNOLOGY CORPORATIONInventors: Elizabeth Ann Vasievich, Weihsu Claire Chen, Kenya N. Toney Johnson, Gregory Conn, Frank Bedu-Addo, Leaf Huang
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Patent number: 11802867Abstract: A measurement method and a measurement reagent for cardiac troponin which enable accurate measurement of the amount of cardiac troponin contained in a sample irrespective of the type of the sample and the presence or absence of other components are disclosed. The measurement method for cardiac troponin, wherein cardiac troponin in a sample separated from a body is measured by an immunoassay, includes a pretreatment step of mixing the sample separated from a body with a pretreatment liquid containing one or both of a surfactant and an acidifier. The reagent for immunoassay of cardiac troponin includes a pretreatment liquid containing one or both of a surfactant and an acidifier.Type: GrantFiled: September 12, 2017Date of Patent: October 31, 2023Assignee: FUJIREBIO INC.Inventors: Mizuho Sakaki, Yoshiyuki Kitamura, Shintaro Yagi, Katsumi Aoyagi
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Patent number: 11802868Abstract: A method for providing variable function medical tests, comprising providing by a mobile device application a plurality of selectable medical test functions, receiving information from the mobile device application regarding test results from a test performed using a testing device, wherein the testing device includes an alignment target disposed on the testing device and a plurality of immunoassay test strips receiving at the server an image of the testing device from the mobile device application, determining by the server RGB values for a plurality of pixels of the image, normalizing by the server the RGB values into a single value, comparing by the server the single value to a control value stored on the server, and providing by the server a risk indicator, wherein the risk indicator indicates a likelihood of a presence of a medical condition.Type: GrantFiled: November 6, 2017Date of Patent: October 31, 2023Assignee: RELIANT IMMUNE DIAGNOSTICS, INC.Inventors: Jovan Hutton Pulitzer, Henry Joseph Legere, III
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Patent number: 11795239Abstract: The invention provides novel compounds, reagents, systems, and methods for detecting a metabolite related to a NRTI in a biological sample, and use thereof in monitoring adherence to pre-exposure prophylaxis or anti-retroviral treatment. Such reagents comprise NRTI derivatives, analogs, NRTI derivatives conjugates, along with antibodies directed to same, which are useful for anti-body-based methods, such as a lateral flow immunoassay and other point of care devices.Type: GrantFiled: October 15, 2018Date of Patent: October 24, 2023Assignee: OraSure Technologies, Inc.Inventors: Giffin Daughtridge, Keith Kardos
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Patent number: 11796548Abstract: Methods are provided herein utilizing a stable cell line capable of efficient infection by African swine fever virus (ASFV) and also provides for the detection of the presence of virus in samples applied to the cells. Detection of the virus by means such as red blood cell rosetting is a surprising result given that the cell line is derived from African green monkeys. This cell line provides a marked improvement over the currently available testing strategies.Type: GrantFiled: April 21, 2021Date of Patent: October 24, 2023Assignee: The United States of America, as represented by The Secretary of AgricultureInventors: Douglas P. Gladue, Ayushi Rai, Manuel V. Borca
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Patent number: 11783876Abstract: Methods, systems, and devices for a multi-port storage-class memory interface are described. A memory controller of the storage-class memory subsystem may receive, from a host device, a request associated with host addresses. The memory controller may generate interleaved addresses with a low latency based on the host addresses. The interleaved addresses parallelize processing of the request utilizing a set of memory media ports. Each memory media port of the set of memory media port may operate independent of each other to obtain a desired aggregated data transfer rate and a memory capacity. The interleaved address may leave no gaps in memory space. The memory controller may control a wear-leveling operation to distribute access operations across one or more zones of the memory media port.Type: GrantFiled: March 9, 2022Date of Patent: October 10, 2023Assignee: Micron Technology, Inc.Inventor: Joseph Thomas Pawlowski
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Patent number: 11772095Abstract: A microfluidic routing device for routing objects of interest in a microfluidic flow includes a substrate; a first layer provided on the substrate, in which the first layer forms a bottom wall of a microfluidic channel. At least two holes through the first layer form respectively an inlet and an outlet for the microfluidic channel The microfluidic routing device further includes a second layer spaced away from the first layer, in which the second layer forms a top wall of the microfluidic channel. The second layer is configured to transmit an optical signal from the microfluidic channel. The microfluidic routing device includes an actuator for actuating the objects of interest in a sorting junction of the microfluidic channel.Type: GrantFiled: December 20, 2018Date of Patent: October 3, 2023Assignee: IMEC VZWInventors: Chengxun Liu, Bivragh Majeed, Abdulkadir Yurt
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Patent number: 11773443Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.Type: GrantFiled: June 11, 2018Date of Patent: October 3, 2023Assignee: EUROFINS LIFECODEXX GMBHInventors: Sebastian Gromminger, Wera Hofmann, Hamed Said
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Patent number: 11768209Abstract: A measurement method and a measurement reagent for thyroglobulin, which enable measurement of a more accurate amount of thyroglobulin by a single test without being influenced by interference of anti-thyroglobulin antibody, are disclosed. The measurement method for thyroglobulin, wherein thyroglobulin in a sample separated from a body is measured by an immunoassay, includes a pretreatment step of mixing the sample separated from a body with a pretreatment liquid containing one or both of a surfactant and an acidifier. The reagent for immunoassay of thyroglobulin includes a pretreatment liquid containing one or both of a surfactant and an acidifier.Type: GrantFiled: September 5, 2017Date of Patent: September 26, 2023Assignee: FUJIREBIO INC.Inventors: Kosuke Yamamoto, Yoshiyuki Kitamura, Shintaro Yagi, Katsumi Aoyagi
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Patent number: 11761024Abstract: A system that indicates the presence or absence of microorganisms in fluid food products. The system has a bottle for receiving sample to be tested. The bottle has a sensor that will monitor and detect changes in at least one sample parameter, but no additives that contain nutrients that support microbial growth. The bottle is placed in an incubator and the sensor in the bottle is monitored for changes. The incubator is programed so that, if the sensor detects that the value of the monitored parameter has reached a certain value, then the sample is determined to be positive for microbial growth.Type: GrantFiled: November 5, 2020Date of Patent: September 19, 2023Assignee: BECTON DICKINSON HOLDINGS PTE LTD.Inventors: Xiao Li, Yan Zhang, Jianwei Liu
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Patent number: 11759102Abstract: This disclosure provides a method for determining the likelihood of being at or beyond a certain rate and/or risk of visual field progression (VFP) of a user, that may include measuring ocular biomechanical properties (OBP) through a continuous-wear sensor placed on or implanted in the eye; recording the user's ocular biomechanical properties in the form of at least one OBP time series plot in a recorder, a processing step wherein at least one of a plurality of OBP parameters are extracted from the recorded OBP time series plot; a calculation step wherein the at least one of a plurality of OBP parameters are associated to VFP, and a determining step wherein one determines whether the visual field progression is at or beyond a certain VFP threshold and/or the probability that the said visual field progression is comprised within a specific range.Type: GrantFiled: May 25, 2022Date of Patent: September 19, 2023Assignee: Sensimed SAInventors: Mario Schlund, Thierry Varidel, Raphael Fritschi, Carlos Gustavo De Moraes
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Patent number: 11761029Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.Type: GrantFiled: September 29, 2020Date of Patent: September 19, 2023Assignee: MAMMOTH BIOSCIENCES, INC.Inventors: Janice Sha Chen, Ashley Tehranchi, Andrew Besancon Lane, James Paul Broughton, Lucas Benjamin Harrington, Maria-Nefeli Tsaloglou, Xin Miao, Clare Louise Fasching, Jasmeet Singh, Pedro Patrick Draper Galarza
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Patent number: 11754565Abstract: The present invention relates to a method of quantifying the amount of Mock Virus Particles (MVP) removed from a solution as a result of processing that solution through a purification technique. This method involves the steps of adding MVP to a solution, processing the solution through a purification technique, quantifying the amount of MVP removed from the solution. The present invention also relates to a kit that can be used in conjunction with the method. This kit will comprise at least one stock solution of MVP and at least one quantification solution.Type: GrantFiled: April 17, 2019Date of Patent: September 12, 2023Assignee: MOCKV SOLUTIONS LLCInventors: David Cetlin, Arun Dhar
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Patent number: 11739125Abstract: The present invention relates to an mRNA sequence, comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory syncytial virus (RSV) or a fragment, variant or derivative thereof. Additionally the present invention relates to a composition comprising a plurality of mRNA sequences comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory syncytial virus (RSV) or a fragment, variant or derivative thereof. Furthermore it also discloses the use of the mRNA sequence or the composition comprising a plurality of mRNA sequences for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the prophylaxis or treatment of RSV infections Respiratory syncytial virus (RSV) infections. The present invention further describes a method of treatment or prophylaxis of RSV infections using the mRNA sequence.Type: GrantFiled: May 11, 2021Date of Patent: August 29, 2023Assignee: Cure Vac SEInventors: Thomas Kramps, Margit Schnee, Daniel Voss, Benjamin Petsch
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Patent number: 11732259Abstract: Oligonucleotide analogues conjugated to carrier peptides are provided. The disclosed compounds are useful for the treatment of various diseases, for example diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.Type: GrantFiled: May 7, 2020Date of Patent: August 22, 2023Assignee: SAREPTA THERAPEUTICS, INC.Inventor: Gunnar J. Hanson
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Patent number: 11728009Abstract: The disclosure provides methods and systems for designing and synthesizing probes to capture a representative sample of genomic variants of a target genome from a sample. The methods include providing a multiple sequence alignment (MSA), designing a plurality of representative subsequences, and optionally synthesizing a nucleic acid probe. The designing step can comprise designating a plurality of intervals in the MSA, shifting start positions for each MSA subset, clustering the aligned subsequences within each adjusted subset, and determining a representative sequence for each reduced MSA subset. The disclosure also encompasses methods of isolating a plurality of nucleic acid variants of a targeted genomic subregion from a sample using the disclosed probe design, as well as the probe compositions themselves.Type: GrantFiled: March 1, 2017Date of Patent: August 15, 2023Assignee: FUSION GENOMICS CORPORATIONInventors: Shing H. Zhan, Brian S. Kwok, Mohammad A. Qadir
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Patent number: 11723922Abstract: The present invention relates to CXCR6-transduced (a) T cell(s) such as (a) CD8+ T cell(s), (a) CD4+ T cell(s), (a) CD3+ T cell(s), (a) ?? T cell(s) or (a) natural killer (NK) T cell(s) for targeted tumor therapy, nucleic acid sequences, vectors capable of transducing such (a) T cell(s), (a) transduced T cell(s) carrying the nucleic acid sequences or vectors of the present invention, methods and kits comprising the nucleic acid sequences or vectors of the present invention. The invention also provides the use of said transduced T cell(s) in a method for the treatment of diseases characterized by CXCL16 overexpression as well as a pharmaceutical composition/medicament comprising (a) transduced T cell(s) expressing the CXCR6 for use in methods of treating diseases characterized by CXCL16 overexpression.Type: GrantFiled: October 14, 2016Date of Patent: August 15, 2023Assignee: LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHENInventors: Sebastian Kobold, Stefan Endres, Moritz Rapp, Simon Grassmann
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Patent number: 11718662Abstract: Disclosed is a method of diagnosing multiple sclerosis (MS), wherein a blood sample from a patient is incubated with a DNA-replication associated (REP) protein. The present invention relates to a DNA-replication-associated (Rep) protein for use in the diagnosis of multiple sclerosis (MS), wherein (a) an increased amount of Rep protein or fragments thereof in the sample as compared to an amount in a control sample; or an increased amount of anti-Rep protein antibodies with antigen in a sample from a subject as compared to an amount in a control sample correlates with a diagnosis of MS, wherein the Rep protein is MSBI1 Rep or MSBI2 Rep.Type: GrantFiled: April 5, 2019Date of Patent: August 8, 2023Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTSInventors: Harald Zur Hausen, Ethel-Michele De Villiers-Zur Hausen, Timo Bund, Sebastian Eilebrecht
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Patent number: 11709163Abstract: The present invention discloses a method and its variations for simultaneous detection of antibodies against two or more antigens of human immunodeficiency virus (HIV) and determination of approximate time (duration) post HIV infection, thereby confirming the infection, and determination of recency of an HIV infection. The number of individuals with recently infected HIV in a given period may be further used to estimate incidence of HIV in a population.Type: GrantFiled: October 7, 2015Date of Patent: July 25, 2023Assignee: AVIOQ, INC.Inventors: Chamroen Chetty, Xing Xiang Li
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Patent number: 11705229Abstract: A method and a device are for exchanging information regarding the clinical implications genomic variations. In an embodiment, the method includes receiving login-data of a user; evaluating the login-data received; establishing an encrypted data connection to the user after the evaluating indicates a positive evaluation of the login-data; saving, upon receiving a dataset in a context of a genomic variation, the dataset received in a memory, context-related with the genomic variation; and evaluating, upon a user request being received and connected with a search query for the genomic variation, a set of datasets from the memory, the datasets being context-related with the genomic variation and the set including the datasets that the user is authorized to receive, and sending the set of datasets to the user.Type: GrantFiled: September 9, 2020Date of Patent: July 18, 2023Assignee: SIEMENS HEALTHCARE GMBHInventors: Oliver Frings, Maximilian Wuerstle, Eugen Kubala, Dominik Neumann, Maximilian Weiss, Carsten Dietrich
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Patent number: 11697844Abstract: The present disclose provides methods and systems for amplifying and quantifying nucleic acids and for detecting the presence or absence of a target in a sample. The methods and systems provided herein may utilize a device comprising a plurality of partitions separated from an external environment by a gas-permeable barrier. Certain methods disclosed herein involve subjecting nucleic acid molecules in the plurality of partitions to conditions sufficient to conduct nucleic acid amplification reactions. The nucleic acid molecules may be subjected to controlled heating in the plurality of partitions to generate data indicative of a melting point(s) of the nucleic acid molecules.Type: GrantFiled: October 30, 2019Date of Patent: July 11, 2023Assignee: Combinati IncorporatedInventors: Ju-Sung Hung, Megan Dueck, Andrew Zayac
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Patent number: 11684918Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.Type: GrantFiled: November 27, 2019Date of Patent: June 27, 2023Assignee: INTEGENX, INC.Inventors: William D. Nielsen, Richard J. Belcinski, Gregory Bogdan, David Eberhart, Omar El-Sissi, Stevan B. Jovanovich, Michael Recknor, Ezra Van Gelder, David Wyrick
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Patent number: 11688110Abstract: A method for evaluating image quality is provided. The method may include: obtaining an image, the image including a plurality of elements, each element of the plurality of elements being a pixel or voxel, each element having a gray level; determining, based on a maximum gray level of the plurality of elements, one or more thresholds for segmenting the image; determining one or more sub-images of a region of interest by segmenting, based on the one or more thresholds, the image; and determining, based on the one or more sub-images of the region of interest, a quality index for the image.Type: GrantFiled: February 21, 2022Date of Patent: June 27, 2023Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.Inventor: Yi Wang
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Patent number: 11686730Abstract: The present disclosure relates to methods and compositions, e.g., kits, for quantitatively detecting an antibody of a subject to an infectious organism. In some embodiments, the present disclosure provides for methods and compositions, e.g., kits, for quantitatively detecting a human antibody to SARS-CoV-2 polypeptide or S (spike) polypeptide. Certain applications and uses of the present methods and compositions, e.g., kits, are also provided.Type: GrantFiled: April 28, 2021Date of Patent: June 27, 2023Assignee: Quanterix CorporationInventors: Andrew Ball, Lei Chang, Syrena Fernandes, Joe Johnson, Jeremy Lambert, Dawn Mattoon, Tatiana Plavina, David Wilson
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Patent number: 11684660Abstract: Disclosed are compositions related to synthetic PD-1 peptides, chimeric PD-1 peptides, anti-PD-1 antibodies and methods of treating cancers, autoimmune diseases, and Alzheimer's disease using said peptides or antibodies.Type: GrantFiled: March 28, 2018Date of Patent: June 27, 2023Assignees: OHIO STATE INNOVATION FOUNDATION, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Pravin T. P. Kaumaya, Tanios Bekaii-Saab
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Patent number: 11680084Abstract: The invention relates to polynucleotides comprising the sequence of a flavivirus preceded by a sequence encoding an N terminal part of a flavivirus Capsid protein, an immunogenic protein, or a part thereof comprising a an immunogenic peptide, and a 2A cleaving peptide, and to the virus encoded by such sequences. The invention further relates to the use of such polynucleotides and viruses as vaccines.Type: GrantFiled: October 5, 2018Date of Patent: June 20, 2023Assignee: KATHOLIEKE UNIVERSITEIT LEUVENInventors: Robbert Boudewijns, Kai Dallmeier, Johan Neyts
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Patent number: 11680945Abstract: A test element for an assay includes: a cartridge having a housing which includes a priming pad capable of containing a liquid fluid, a wash port having an opening in the housing, and an opening for directly or indirectly applying a sample; and an assay device positioned within the cartridge in fluid communication with the wash port containing an analytical reagent.Type: GrantFiled: December 14, 2020Date of Patent: June 20, 2023Assignee: Ortho Clinical Diagnostics, Inc.Inventor: Raymond F. Jakubowicz