Involving Virus Or Bacteriophage Patents (Class 435/5)
  • Patent number: 11505837
    Abstract: Methods and techniques to increase the reliability of detecting virus infections, particularly lymphotropism, to eliminate false negative reactions in testing blood for the presence of lymphotropic viruses during enzyme immunoassay (EIA) and polymerase chain reaction (PCR) testing, and to better detect viruses with lymphotropism in biological materials having a concentration of virus particles lower than the sensitivity threshold of existing EIA and PCR methods, thereby making the techniques of the present invention more reliable.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: November 22, 2022
    Inventor: Ovik Leonardovich Mkrtchyan
  • Patent number: 11499128
    Abstract: An organ-on-chip apparatus includes a first fluid channel, a second fluid channel, and an interface. Respective portions of the first fluid channel and the second fluid channel may extend parallel to and adjacent each other, and the interface may be disposed between the respective portions of the first fluid channel and the second fluid channel such that fluid exchange between the first fluid channel and the second fluid channel is via the interface. The first and second fluid channels may be defined in an extracellular matrix material.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: November 15, 2022
    Assignee: The Regents of the University of Colorado
    Inventors: Kambez Hajipouran Benam, Alex Kaiser
  • Patent number: 11502299
    Abstract: Improved high energy capacity designs for lithium ion batteries are described that take advantage of the properties of high specific capacity anode active compositions and high specific capacity cathode active compositions. In particular, specific electrode designs provide for achieving very high energy densities. Furthermore, the complex behavior of the active materials is used advantageously in a radical electrode balancing design that significantly reduced wasted electrode capacity in either electrode when cycling under realistic conditions of moderate to high discharge rates and/or over a reduced depth of discharge.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: November 15, 2022
    Assignee: Zenlabs Energy, Inc.
    Inventors: Charan Masarapu, Haixia Deng, Yongbong Han, Yogesh Kumar Anguchamy, Subramanian Venkatachalam, Sujeet A. Kumar, Herman A. Lopez
  • Patent number: 11493466
    Abstract: Sensors having an advantageous design and methods for fabricating such sensors are generally provided. Some sensors described herein have pairs of electrodes having radial symmetry, pairs of nested electrodes, and/or nanowires. Some embodiments relate to fabricating electrodes by methods in which nanowires are deposited from a fluid contacted with a substrate in a manner such that it evaporates and is replenished.
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: November 8, 2022
    Assignee: NanoDX, Inc.
    Inventors: Farhad Khosravi, David Bastable, Sergey A. Dryga
  • Patent number: 11493505
    Abstract: There are provided methods and systems for detecting and/or quantifying an analyte. In particular, there are provided methods and systems for simultaneous detection and/or quantitation of two or more analytes in a sample. In some embodiments, there are provided colocalization-by-linkage assays on microparticles (CLAMP) comprising two sets of binders pre-assembled on a support, such that the two sets of binders are colocalized before contacting the sample.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: November 8, 2022
    Inventors: David Juncker, Milad Dagher
  • Patent number: 11492655
    Abstract: A method of detecting a nucleic acid including a) mixing a solution containing a carboxylic acid and/or a salt thereof, a cerium oxide support and a sample containing a nucleic acid to adsorb said nucleic acid to said cerium oxide support, b) separating said cerium oxide support on which said nucleic acid was adsorbed from the mixture obtained in a), c) collecting said nucleic acid by adding an eluent to said cerium oxide support on which said nucleic acid was adsorbed and separated in b), and d) detecting said nucleic acid collected in c) by a hybridization reaction or a nucleic acid amplification reaction.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: November 8, 2022
    Assignee: Toray Industries, Inc.
    Inventors: Shota Sekiguchi, Mai Nakagawa, Masateru Ito, Shinjiro Sawada
  • Patent number: 11479587
    Abstract: The present invention generally relates to the field of antimicrobial peptides (AMPs), and more specifically to cationic intrinsically disordered antimicrobial peptides (CIDAMPs) and their use as disinfectants and therapeutic agents for the treatment of infections, especially as a therapeutic alternative for the treatment of infectious diseases caused by antibiotic resistant microorganisms.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: October 25, 2022
    Assignee: Christian-Albrechts-Universität zu Kiel
    Inventor: Jens-Michael Schröder
  • Patent number: 11473121
    Abstract: The invention generally relates to analyzing yeast viability. More particularly, the invention relates to efficient and effective methods and compositions for accessing and measuring viability and concentration of yeast cells.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: October 18, 2022
    Inventor: Leo L. Chan
  • Patent number: 11473141
    Abstract: The present invention relates to probes and primers beneficial for conducting amplification assays, such as those including loop-mediated isothermal amplification reactions. Also described herein are methods for detecting targets using such probes and/or primers.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: October 18, 2022
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Robert Meagher, Chung-Yan Koh, Yooli Kim Light, Cameron Scott Ball
  • Patent number: 11473155
    Abstract: Herein disclosed are rapid real-time isothermal multiplex methods of detecting, identifying and quantifying bacterial, viral, and protozoan nucleic acids in a sample. These include contacting the sample with two or more sets of pathogen-specific reverse transcription loop-mediated isothermal amplification primers and novel oligofluorophores specific for the target bacterial, viral, and parasitic nucleic acids of interest such as human immunodeficiency virus, Ebola virus, Marburg virus, Yellow fever virus, hepatitis-B virus, Lassa fever virus, Plasmodium, hepatitis-C virus, hepatitis-E virus, dengue virus, Chikungunya virus, Japanese Encephalitis virus, Middle Eastern Respiratory Syndrome Corona virus, Mycobacterium, West Nile virus, Cytomegalovirus, Parvovirus, Leishmania, Trypanosoma, and Zika virus nucleic acids, under conditions sufficient to produce detectable real-time amplification signals in about 10 to 40 minutes.
    Type: Grant
    Filed: August 24, 2019
    Date of Patent: October 18, 2022
    Inventor: Dougbeh-Chris Nyan
  • Patent number: 11466311
    Abstract: The present invention relates to methods and devices for identifying and quantifying, including low abundance, nucleotide base mutations, insertions, deletions, translocations, splice variants, miRNA variants, alternative transcripts, alternative start sites, alternative coding sequences, alternative non-coding sequences, alternative splicings, exon insertions, exon deletions, intron insertions, or other rearrangement at the genome level and/or methylated nucleotide bases.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: October 11, 2022
    Inventors: Francis Barany, John William Efcavitch, Cristian Ruiz Rueda, Jianmin Huang, Philip B. Feinberg
  • Patent number: 11466317
    Abstract: Methods of characterizing an analyte using a nanopore. One aspect features methods for characterizing a double-stranded polynucleotide using a nanopore, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: October 11, 2022
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: James Clarke, James White, Richard Muscat, Jessica Mary May Knott, Ramiz Iqbal Nathani, Andrew John Heron, Mark John Bruce, Lakmal Nishantha Jayasinghe, Domenico Caprotti, David Jackson Stoddart, Rebecca Victoria Bowen, Christopher James Wright, Paul Richard Moody
  • Patent number: 11466314
    Abstract: Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as a rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1, 2, 3 or more targets in a sample by color.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: October 11, 2022
    Assignee: Agilent Technologies, Inc.
    Inventors: Jesper Lohse, Mike Paw Maischnack Hansen
  • Patent number: 11465142
    Abstract: This invention relates generally to devices, systems, and methods for performing biological assays by using indicators that modify one or more optical properties of the assayed biological samples. The subject methods include generating a reaction product by carrying out a biochemical reaction on the biological sample introduced into a device and reacting the reaction product with an indicator capable of generating a detectable change in an optical property of the biological sample to indicate the presence, absence, or amount of analyte suspected to be present in the sample.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: October 11, 2022
    Assignee: Lucira Health, Inc.
    Inventors: Frank B. Myers, III, Clay D. Reber, Taber H. Smith, Faisal S. Maniar
  • Patent number: 11459608
    Abstract: Fluorescence imaging system designs are described that provide larger fields-of-view, increased spatial resolution, improved modulation transfer and image quality, higher spatial sampling frequency, faster transitions between image capture when repositioning the sample plane to capture a series of images (e.g., of different fields-of-view), and improved imaging system duty cycle, and thus enable higher throughput image acquisition and analysis for genomics and other imaging applications.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: October 4, 2022
    Inventors: Steve Xiangling Chen, Minghao Guo, Michael Previte, Chunhong Zhou, Derek Fuller
  • Patent number: 11459604
    Abstract: Apparatus and methods for analyzing samples, including for example, samples containing nucleic acids, antibodies, and/or antigens are described. The apparatus may include a frame having a cartridge receiver, two optical devices, thermal cycler, lysis assembly, hybridization heater, and sample transfer assembly. In use, the apparatus may perform multiple sample preparation and analysis processes within the same disposable cartridge including, for example, performing a PCR assay and immunoassay in the same cartridge.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: October 4, 2022
    Inventors: Charles Collins, Dave Smith, Anthony Salvaggio, Alpar Erdei, Gray Mack
  • Patent number: 11462332
    Abstract: Disclosed herein are systems and methods for the mass testing of a population for an infection. Pooled sampling may be used to reduce the number of tests needed for effective community surveillance. Individual members may be sorted into pools via a probability of infection to minimize the tests needed to identify positive individuals. The detection limits of testing assays may be used to help determine an appropriate pool size. Taxonomy tables characterizing the solution space of the total tests needed based on different variables may be generated and/or used to make testing decisions. Simulations of mass testing schemes may be used to facilitate testing decisions. Systems may be used to coordinate data and/or automate one or more steps of the testing process. Long-term community surveillance strategies may use prevalence testing, periodic mass testing via sample pooling, and/or periodic single sample testing to contain the spread of a contagion.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: October 4, 2022
    Assignee: Smart Testing, LLC
    Inventor: Rangaswamy Rajagopal
  • Patent number: 11459624
    Abstract: The invention provides a method for determining whether a human immunodeficiency virus is resistant to a viral entry inhibitor. The methods are particularly useful for determining resistance to inhibitors that act by a non-competitive mechanism. In certain aspects, the methods comprise determining whether an HIV population is resistant to an HIV entry inhibitor, comprising determining a log-sigmoid inhibition curve comprising data points for entry of the HIV population in the presence of varying concentrations of the HIV entry inhibitor, wherein if the entry of the HIV population cannot be completely inhibited by the HIV entry inhibitor, the HIV population is resistant to the HIV entry inhibitor.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: October 4, 2022
    Assignee: Monogram Biosciences, Inc.
    Inventor: Christos J. Petropoulos
  • Patent number: 11452769
    Abstract: The invention provides compositions and methods for preventing and treating infection by Plasmodium sporozoites.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: September 27, 2022
    Assignee: Yale University
    Inventors: Erol Fikrig, Yang Zhao
  • Patent number: 11453877
    Abstract: The present invention provides, among other things, methods for purifying high quality messenger RNA (mRNA) suitable for clinical use, without using any caustic or flammable solvents. The present invention is, in part, based on surprising discovery that mRNA can be successfully purified by selective precipitation and washing without using ethanol while maintaining integrity and high purity of mRNA. Thus, the present invention provides an effective, reliable, and safer method of purifying RNA from large scale manufacturing process therapeutic applications without using any caustic or inflammable solvents.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: September 27, 2022
    Assignee: Translate Bio, Inc.
    Inventors: Jonathan Abysalh, Frank DeRosa, Jorel E. Vargas, Cameron M. Smith
  • Patent number: 11453848
    Abstract: The presently disclosed subject matter provides a biomimetic organ model, and methods of its production and use. In one exemplary embodiment, the biomimetic organ model can be a multi-layer model including a at least two microchannels and at least one chamber slab with at least one membrane coated with cells disposed between at least one microchannel and the at least one chamber slab. In another exemplary embodiment, the biomimetic organ disease model can be a five-layer model including a first and second microchannel with a membrane-gel layer-membrane coated or encompassing cells disposed between the microchannels. In certain embodiments, at least one device can be coupled to the biomimetic organ model that delivers an agent to at least one microchannel.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: September 27, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Dongeun Huh, Mark Mondrinos
  • Patent number: 11453907
    Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: September 27, 2022
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure
  • Patent number: 11453706
    Abstract: This disclosure is directed to immune treatment of a disease (e.g., an infectious disease) using a fusion protein in combination with an anti-chemorepellant agent. In particular, the fusion protein comprises an antigen-binding domain (e.g., an antibody or antibody fragment) and a stress protein domain.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: September 27, 2022
    Assignee: The General Hospital Corporation
    Inventors: Mark C. Poznansky, Jeffrey A. Gelfand
  • Patent number: 11452454
    Abstract: A non-invasive, transcutaneous, real-time viral detection device that is configured for self-administration, e.g., at a user's home. In one embodiment, and after positioning the device relative to the human body part (e.g., the user's finger), light sources in the device are activated (excited), and resulting data captured. In particular, a set of Raman spectra are collected from a configured set of emitters and detectors in the device and delivered to a nearby receiver, preferably wirelessly. The receiver filters and de-convolves the Raman spectra producing a data set representative of the constituent elements in the user's tissue of interest. The data set is applied against a statistical classifier, e.g., a neural network that has been trained to recognize and distinguish the absence or presence of viral components, e.g., C-19, or its associated blood-borne acute phase reactants.
    Type: Grant
    Filed: April 18, 2022
    Date of Patent: September 27, 2022
    Assignee: 123IV, Inc.
    Inventors: Allen B. Chefitz, Rohit Singh
  • Patent number: 11446366
    Abstract: The present specification disclose methods and uses for the treatment of a vasculitic syndrome. The disclosed methods comprise administering a composition comprising a Proteinase 3 (PR3) inhibitor to a patient in need thereof. Also disclosed are compositions comprising a PR3 inhibitor disclosed herein for use in the treatment of a vasculitic syndrome as well as use of a composition comprising a PR3 inhibitor disclosed herein in the treatment of a vasculitic syndrome. The present specification also discloses use of a composition comprising a PR3 inhibitor disclosed herein in the manufacture of a medicament for the treatment of a vasculitic syndrome.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: September 20, 2022
    Assignee: Canem Holdings, LLC
    Inventor: Adam Haeberle
  • Patent number: 11447835
    Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis C virus (HCV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the 5? untranslated region of HCV and are configured to provide substantially equivalent quantification of different genotypes and variants of HCV.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: September 20, 2022
    Inventors: Siobhan Miick, Paul M. Darby, Jo Ann Jackson, Sheila M. J. Aubin
  • Patent number: 11447834
    Abstract: Disclosed are novel genetic arrays for use in the molecular detection of multiple Salmonella serovars, common food-borne and water-borne pathogens. The arrays may be used to simultaneously detect multiple food safety Salmonella serovars. The multiplex-detection methods have improved sensitivity and specificity for the detection of multiple high-impact food-borne pathogens simultaneously. Real-time PCR assaying techniques using such serovars include microarrays.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: September 20, 2022
    Inventors: Woubit Abebe, Khaled Aldhami, Sayma Afroj, Temesgen Samuel, Gopal Reddy
  • Patent number: 11441167
    Abstract: The present invention relates to compositions and methods for the use of polymerase chain reaction (PCR) as a reporter assay for rapid and simultaneous bacterial identification and phenotype testing for antimicrobial susceptibility (AST). The current invention uses a strategy that has shown the ability for multiplexing and for handling polymicrobial samples for antimicrobial susceptibility testing.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: September 13, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Kyle C. Cady, Brett Hanson, Paulino Abdon, Ryan Chan, Patrick Lin, Rochak Mehta, Troy Rabang
  • Patent number: 11440946
    Abstract: A universal antibody-mediated biosensor is provided that comprise a biosensor cell line stably expressing a novel chimeric fusion protein that can be used to detect target agents in a sample. The fusion protein has an extracellular antibody-binding domain that binds antibodies without regard to their binding specificity and a signaling domain that induces cellular activation upon antigen binding. Because the fusion protein binds to the Fc region of any antibody, it can serve as a universal pathway between extracellular signaling and intracellular activation. The biosensor can be used to detect the presence of selected antigens in a sample.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: September 13, 2022
    Inventors: Dan Schulze, Scott E. Strome
  • Patent number: 11438982
    Abstract: A control system for an LED array includes a pulse width modulator to supply signals having rising edges and a falling edges to the plurality of LEDs. A plurality of parasitic capacitance discharge circuit elements connected in parallel between the pulse width modulator and the respective LEDs.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: September 6, 2022
    Assignee: Lumileds LLC
    Inventor: Zhi Hua Song
  • Patent number: 11433132
    Abstract: The present invention relates to anti-polyomavirus antibodies, antibody fragments, and their uses for the prevention and treatment of BK or JC virus infection and associated diseases.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: September 6, 2022
    Assignee: Novartis AG
    Inventors: Johanna Abend, Vanessa Cornacchione, John Michael Lindner, Elisabetta Traggiai
  • Patent number: 11414491
    Abstract: This document relates to materials and methods for treating cancer. For example, this document provides materials and methods for using PD-L1 targeting domains in bispecific chimeric polypeptides, chimeric transmembrane polypeptides, genetically modified viruses, nucleic acid vectors, and/or fusion-inducing cells to treat cancer.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: August 16, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Stephen James Russell, Autumn J. Schulze, Arun Ammayappan, Kah-Whye Peng, Camilo Ayala Breton
  • Patent number: 11414714
    Abstract: The present invention relates to means, methods and kits for the specific detection of the causing agent of powdery mildew on grapes, the fungus Erysiphe necator. More specifically, the methods according to the invention are quantitative methods based on quantitative Polymerase Chain Reaction.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: August 16, 2022
    Assignee: Bayer SAS
    Inventors: Patrice Dubournet, Semcheddine Cherrad, Sébastien Vacher
  • Patent number: 11415570
    Abstract: The present invention is related to the field of bio/chemical sensing, assays and applications. Particularly, the present invention is related to collecting a small amount of a vapor condensate sample (e.g. the exhaled breath condensate (EBC) from a subject of a volume as small as 10 fL (femto-Liter) in a single drop), preventing or significantly reducing an evaporation of the collected vapor condensate sample, analyzing the sample, analyzing the sample by mobile-phone, and performing such collection and analysis by a person without any professionals.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: August 16, 2022
    Assignee: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding
  • Patent number: 11406296
    Abstract: A system and method is provided for analyzing a glucose state. A method may include identifying a target glucose state and an initial glucose state. The method may include calculating a target return path for a transition from the initial glucose state to the target glucose state. The target return path may comprise at least one intermediate glucose state associated with the transition from the initial glucose state to the target glucose state. The target return path may be calculated based on a hazard associated with the at least one intermediate glucose state of the target return path.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: August 9, 2022
    Assignee: Roche Diabetes Care, Inc.
    Inventors: David L. Duke, Abhishek S. Soni
  • Patent number: 11408888
    Abstract: Provided are methods, assays, and kits for detecting hepatocellular carcinoma, as well as methods for stratifying subjects among higher and lower risk categories for having hepatocellular carcinoma, and methods of treating and managing treatment of subjects that are suspected or at risk of having hepatocellular carcinoma. Although previous work has attempted to address the need for a highly sensitive, early predictor of hepatocellular carcinoma by assessment of one or more biological factors, none have approached the degree of sensitivity that is required for clinically relevant determination of whether a subject, especially a non-symptomatic subject, has that condition. The present inventors have discovered that certain combinations of factors fulfill this need by conferring a high level of accuracy that was not previously attainable.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: August 9, 2022
    Assignee: Drexel University
    Inventors: Timothy M. Block, Mengjun Wang, Anand Mehta, Mary Ann Comunale
  • Patent number: 11399812
    Abstract: A biopsy device includes a body, a needle, a tissue sample holder and a sensor. The needle extends from the body. The tissue sample holder is in communication with the needle to receive one or more tissue samples within a sample chamber defined by the tissue sample holder. The tissue sample holder includes a receiving cavity. The sensor is configured to detect x-rays. The receiving cavity is sized and shaped to receive the sensor such that the sensor is removably positioned within the tissue sample holder.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: August 2, 2022
    Assignee: Devicor Medical Products, Inc.
    Inventors: Bryan R. Keller, Patrick A. Mescher
  • Patent number: 11401546
    Abstract: The present invention relates to the detection of a target nucleic acid sequence by a PTOCE-E (PTO Cleavage and Extension-dependent Extension) assay. The PTOCE-E assay of the present invention can reduce the non-target signal and increase the target signal as compared with the conventional PTOCE and PCE-SH methods, thereby enabling more accurate detection of the target nucleic acid sequence.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: August 2, 2022
    Assignee: SEEGENE, INC.
    Inventors: Young Jo Lee, Han Bit Lee, Dae Young Kim
  • Patent number: 11401654
    Abstract: Methods and apparatus for pre-treating swabs prior to collection of specimens to reduce false positive detections by immersing a swab in a liquid chemical pre-treating agent for a treatment period of time. Then the swab is removed and circulated in a rinse agent. The pre-treating agent may be an oxidizing agent, a reducing agent, a bleaching agent (e.g. sodium hypochlorite solution) or a fluorescence suppressing dye (such as Evans blue, Trypan blue, or black dye).
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: August 2, 2022
    Assignee: SoftRay, Inc.
    Inventor: Paul E. Johnson
  • Patent number: 11390925
    Abstract: The present invention provides a method for detecting a microorganism in a sample, the method comprising: a) filtering a sample through a filter to entrap any microorganisms present in the sample; b) treating the filter to release genomic material or DNA from the entrapped microorganisms; c) amplifying the genomic material or DNA released from the entrapped microorganisms; and d) identifying specific regions of the genomic material or DNA to determine the presence, identify the species or quantify the approximate number of any entrapped microorganisms.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: July 19, 2022
    Assignee: Corsham Science Limited
    Inventors: Tamryn Jo Hassel, Ruth Catherine Massey, Leann Francis Bacon
  • Patent number: 11391741
    Abstract: The present invention is to provide a method of exosome analysis that can analyze exosome in a sample in a simple manner. The method of exosome analysis of the present invention is a method of analyzing exosome in a sample, including: an addition step of adding a first antibody that specifically binds to a first antigen contained in the exosome and a second antibody that specifically binds to a second antigen contained in the exosome to the sample; a reaction step of causing the first antigen to be reacted with the first antibody and the second antigen to be reacted with the second antibody; and a detection step of detecting a reaction between the first antigen and the first antibody and a reaction between the second antigen and the second antibody.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: July 19, 2022
    Assignee: THEORIA Science Inc.
    Inventor: Takahiro Ochiya
  • Patent number: 11391745
    Abstract: Objects of the present invention are to find a marker by which progression of arteriosclerosis can be directly grasped, to thereby provide motivation for prevention or treatment of arteriosclerosis itself, and to provide means for accurately grasping condition of arteriosclerosis-related disease including arteriosclerotic disease. The invention provides a method for acquiring data on progression of arteriosclerosis, the method including determining a level of an antibody against SH3BP5 protein or a part thereof in a body fluid sample collected from a biological body, and a data acquisition kit for performing the data acquisition method.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: July 19, 2022
    Assignees: FUJIKURA KASEI CO., LTD., National University Corporation Chiba University
    Inventors: Hideyuki Kuroda, Rika Nakamura, Go Tomiyoshi, Takaki Hiwasa
  • Patent number: 11384387
    Abstract: The disclosed disclosure is related to methods, compositions, and kits for targeting Adenovirus, nucleic acid. Compositions include amplification oligomers and/or detection probe oligomers. Kits and methods comprise at least one of these oligomers. Methods include uniplex and multiplex amplification and detection reactions.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: July 12, 2022
    Inventors: Mehrdad R. Majlessi, Ankur Shah, Amber Hillius, Pamela Douglass, Daniel Kolk
  • Patent number: 11384398
    Abstract: The disclosure is directed to kits and methods for amplifying and detecting human papilloma virus (HPV) of genotype 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and/or 68 in a sample, which comprises a variety of combinations of forward oligonucleotide primers, reverse oligonucleotide primers, and oligonucleotide probes.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: July 12, 2022
    Inventors: Wesley Grimm, Joshua Kostera, Robert Hillman, Hong Wang, Ning Tang, Shihai Huang, Klara Abravaya
  • Patent number: 11377356
    Abstract: Disclosed are the methods for fabricating holey graphene nanoplatelets using microwave irradiation to treat a dry graphite powder. In particular, the methods can be used to treat graphite intercalation compounds either with or without partial oxidation to obtain holey graphene nanoplatelets with predetermined hole size, hole edge shape, thickness and lateral dimension. The method does not involve any toxic reagents or metal-containing compounds, and without generating toxic byproducts, thus enabling a variety of eco-friendly applications.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: July 5, 2022
    Inventors: Huixin He, Keerthi Savaram, Qingdong Li
  • Patent number: 11378573
    Abstract: A method of analyzing a biological sample using an analyzer and an assay. The method comprises providing the assay for producing the signal. The assay has two or more predetermined number of components. Each of the predetermined components has a distinct relation between the intensive property and the signal. The method further comprises providing calibration samples with known values for the intensive property and measuring a calibration signal for each of the calibration samples. The method further comprises determining a calibration by fitting a calibration function to the calibration signal for each of the calibration samples and the known values for the intensive property. The calibration function is equivalent to a constant plus an exponential decay term for each of the predetermined number of components. The method further comprises measuring the signal of the sample using the analyzer and the assay, and calculating the intensive property using the calibration.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: July 5, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Wilhelm Kleider, Hans-Dieter Kraemer, Peter Sluka
  • Patent number: 11369691
    Abstract: The present invention relates to a pharmaceutical composition comprising a modified mRNA that is stabilised by sequence modifications and optimised for translation. The pharmaceutical composition according to the invention is particularly well suited for use as an inoculating agent, as well as a therapeutic agent for tissue regeneration. In addition, a process is described for determining sequence modifications that promote stabilisation and translational efficiency of modified mRNA of the invention.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: June 28, 2022
    Assignee: CureVac AG
    Inventors: Florian Von Der Mülbe, Ingmar Hoerr, Steve Pascolo
  • Patent number: 11366093
    Abstract: A disposable system, in some embodiments, includes a multi-channel or multi-chamber test cartridge device configured to operate with a testing system for evaluation of hemostasis in a subject by in vitro evaluation of a test sample from the subject. The disposable system, in some embodiments, is configured to interrogate the test sample to evaluate clot stiffness, strength, or other mechanical properties of the test sample to assess the function of various physiological processes occur during coagulation and/or dissolution of the resulting clot.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: June 21, 2022
    Assignee: HEMOSONICS, LLC
    Inventors: Francesco Viola, Timothy Higgins, Andrew Homyk, F. Scott Corey, Franklin F. Regan, William F. Walker, David Bryant, Thomas Givens, Cynthia Ann Lloyd
  • Patent number: 11364494
    Abstract: The invention relates to an array type paper chip for 2019-nCoV virus high-throughput detection and a manufacturing method of the array type paper chip. The array type paper chip comprises a glass substrate layer, a paper unit layer and a cell grid layer which are arranged in sequence from bottom to top, wherein the grid layer comprises N circular paper detection units with a diameter R being arranged in the form of an array; and the unit grids of the unit grid layer are in one-to-one correspondence to the paper detection units to separate the paper detection units. The array type paper chip is simple in structure, the manufacturing process is simple and stable, the finished products are stable, requirements on the processing environment and conditions are very low, and processing equipment is low in price. Moreover, the processing process does not revolve any chemical reagent, and therefore, the method is more environmentally friendly than methods such as ultraviolet lithography.
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: June 21, 2022
    Inventors: Hao Sun, Hui Dong, Yuan Jia
  • Patent number: 11367606
    Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: June 21, 2022
    Assignee: Micromass UK Limited
    Inventors: Zoltan Takats, Emrys Jones, James Ian Langridge, Michael Raymond Morris, Tamas Karancsi, Steven Derek Pringle, Julia Balog, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Keith Richardson, Phillip Robert Bennett, David Alan MacIntyre, Pamela Pruski