Involving Virus Or Bacteriophage Patents (Class 435/5)
  • Patent number: 11926861
    Abstract: The invention describes a method for determining how to stimulate, monitor and/or inhibit virus production in whole blood culture. The invention relates to a test kit for performing the method and to the use of a suitable blood sampling system. The system can be used to determine how to activate or target latently HIV-infected cells, for clinical management of HIV treatments and for personalized therapeutic strategies.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: March 12, 2024
    Inventor: Heidi Kay
  • Patent number: 11919971
    Abstract: This disclosure provides, e.g., methods for coupling Formation of Surface Carboxylates on PES an entity to a solid substrate. The method can comprise treating the with Exposure Time substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: March 5, 2024
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Daniel Christopher Leslie, Thomas Doyle, Anna Waterhouse, Melissa Rodas, Alexander L. Watters, Michael Super, Donald E. Ingber
  • Patent number: 11920168
    Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having nuclease grafted to one or more capsid proteins. In some aspects, the disclosure relates to isolated AA V capsid proteins having terminally grafted nucleases and isolated nucleic acids encoding the same. Recent approaches to delivering nucleases to cells for gene editing have focused on delivering of expression vectors engineered to express the nucleases in target cells. However, these approaches have proved to be problematic in many instances due to genotoxicity resulting from to prolonged expression of gene editing system in vivo. To prevent such off-target genotoxicity due to prolonged presence of a gene editing system, several studies explored delivery of mRNA or protein instead of delivering the gene coding for the nucleases in cell culture.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: March 5, 2024
    Assignee: University of Massachusetts
    Inventors: Guangping Gao, Phillip D. Zamore, Dan Wang
  • Patent number: 11913082
    Abstract: Methods are provided for a sensitive and specific assay for the determination of viral load and genotyping of RSV in a biological sample. Compositions and kits for use in the methods also are provided, including optimized primers for the amplification of and detection of the RSV open reading frames from subtypes A and B, and probes for distinguishing between the subtypes. Also provided are methods for amplifying and sequencing an open reading from of an RSV F protein, and compositions and kits for use in the methods.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: February 27, 2024
    Assignee: Laboratory Corporation of America Holdings
    Inventor: Justin Philip De La Cruz
  • Patent number: 11906515
    Abstract: A multiplexed lateral flow device includes an impermeable internal reservoir having an opening to receive a sample deposition. A fluid distributor pad is arranged in fluid communication with a lower surface of the internal reservoir. The fluid distributor pad includes a paper based microfluidic element having a pattern of a hydrophobic material to distribute a portion of the sample deposition substantially equally among a plurality of flow paths. Lateral flow assays having a plurality of flow lines are aligned with flow paths of the distributor pad. An impermeable top cover has a first window arranged over the opening of the internal reservoir, and at least a second window arranged over the test results of the lateral flow assays. A housing element houses the reservoir, the distributor pad and lateral flow assays.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: February 20, 2024
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, FUNDACAO OSWALDO CRUZ
    Inventors: Jaione Tirapu Azpiroz, Ademir Ferreira da Silva, Matheus Esteves Ferreira, Ricardo Luis Ohta, Mathias B. Steiner, Antonio Gomes Pinto Ferreira, Edimilson Domingos da Silva, Nara Mazarakis Rubim, Pedro Paulo Ferreira Ribeiro
  • Patent number: 11908140
    Abstract: Disclosed is a method and system for identifying a protein domain based on a protein three-dimensional structure image. According to the present application, the protein domain is identified based on a structure similarity, the identification errors and omissions of the protein domain caused by protein multi-sequence alignment errors when sequence consistency is not high can be effectively solved. According to the present application, the point cloud segmentation model based on the dynamic graph convolutional neural network is constructed, and by integrating global structural features and local structural features, segmentation of the protein domain and acquisition of semantic labels of the protein domain can be completed at the same time.
    Type: Grant
    Filed: August 2, 2023
    Date of Patent: February 20, 2024
    Assignee: ZHEJIANG LAB
    Inventors: Jingsong Li, Jing Ma, Yu Wang
  • Patent number: 11898201
    Abstract: Methods and compositions are provided for improved nucleic acid amplification assays. In some embodiments, the nucleic acid amplification assay is a tagged amplicon primer extension (TAPE) nucleic acid amplification reaction.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: February 13, 2024
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Nicholas Heredia, Dianna Maar
  • Patent number: 11891656
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: February 6, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Hu Cang, Zhenmin Hong
  • Patent number: 11890826
    Abstract: A method of enhancing a footwear impression formed on a porous surface using a potassium ferrocyanide solution for footwear impression enhancement includes: forming a porous surface sample by leaving footwear impressions into an object having a porous surface; preparing a potassium ferrocyanide solution for footwear impression enhancement; and applying the potassium ferrocyanide solution for footwear impression enhancement to the porous surface sample.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: February 6, 2024
    Assignee: REPUBLIC OF KOREA (NATIONAL FORENSIC SERVICE DIRECTOR MINISTRY OF THE INTERIOR AND SAFETY)
    Inventors: Nam Kyu Park, Byung Seon Moon, Jae Mo Goh, Jin Pyo Kim, Young Il Seo, Eun Ah Joo, Je Hyun Lee, Yong Jun Kim
  • Patent number: 11887830
    Abstract: A method and apparatus for monitoring and/or controlling the extent of denaturation and/or bond cleavages of proteins on any surface (e.g., biological tissues, biofilms, etc.). In one embodiment, a low power laser (e.g., a 5 mW, 362 nm diode laser) is directed through a biological sample to a photodetector. The sample is heated by a set of radiant heaters to between about 220° C. and about 250° C. in a time period of between 10 seconds to 60 seconds. The baseline transmissivity of the sample is monitored continuously throughout treatment of the biological sample via continuous monitoring of the signal voltage detected at the photodetector. Upon detection of increase in relative transmissivity in the biological sample, the heating treatment is concluded and the biological sample is removed for in situ protein identification as part of an imaging MALDI-MS measurement.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: January 30, 2024
    Assignee: UNIVERSITY OF WYOMING
    Inventors: Erica Belmont, Franco Basile, James Rundel, Andrew Goodenough
  • Patent number: 11857619
    Abstract: Described herein is a process for protein purification, particularly a process for the purification of a glycoprotein, such as an HIV envelope protein, useful for vaccines or biotherapeutics.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: January 2, 2024
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventors: Christopher Rode, Brian Polilli, John Schreffler
  • Patent number: 11852968
    Abstract: To provide a pellicle in which outgas from an adhesive layer is suppressed. The pellicle includes a pellicle film, a support frame for supporting the pellicle film, a protrusion part arranged in the support frame, a first adhesive layer arranged on the protrusion part; and an inorganic material layer arranged at a position closer to the pellicle film than the first adhesive layer. The inorganic material layer may include a first inorganic material layer arranged at a first side surface of the first adhesive layer, the first side surface of the first adhesive layer intersecting the pellicle film, and arranged at a position closer to the pellicle film.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: December 26, 2023
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Yosuke Ono, Kazuo Kohmura, Atsushi Okubo, Daiki Taneichi, Hisako Ishikawa, Tsuneaki Biyajima
  • Patent number: 11851701
    Abstract: A probe comprising a reporter region for detecting a first single nucleotide polymorphism, an anchor region for detecting a second single nucleotide polymorphism, and a linker region is disclosed. The reporter region comprises an oligonucleotide consisting of a sequence perfectly matching with the first target sequence, and a fluorescent dye that quenches when hybridized to the first target sequence where the first single nucleotide polymorphism is present. The anchor region comprises an oligonucleotide consisting of a sequence perfectly matching with a second target sequence where the second single nucleotide polymorphism is present. A length of the oligonucleotide of the reporter region is shorter than a length of the oligonucleotide of the anchor region.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: December 26, 2023
    Assignee: EIKEN KAGAKU KABUSHIKI KAISHA
    Inventor: Atsuka Matsui
  • Patent number: 11845958
    Abstract: Genetically modified CCNT1 and XPO1 genes encoding proteins that inhibit virus infection in cells. The genetically modified CCNT1 gene encodes a protein with a C261Y substitution with respect to the human CCNT1 protein. The genetically modified XPO1 gene encodes a protein with P411T, M412V, and/or F414S substitutions with respect to the human XPO1 protein. The genetically modified CCNT1 and XPO1 genes can be introduced in cells. The cells comprising the genetically modified CCNT1 and XPO1 genes can be introduced in a subject with a virus infection to treat the infection.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: December 19, 2023
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nathan Mark Sherer, Ryan Thomas Behrens
  • Patent number: 11839605
    Abstract: A non-injectable formulation or formulation for instillation, including self-assembling hydrogels formed of gelators such as the Food and Drug Administration's Generally Regarded as Safe (GRAS) compounds like ascorbyl palmitate, in the form of capsules, tablets, oral suspensions, enemas, and rectal or vaginal suppositories or inserts have been developed. In a preferred embodiment, the formulation contains anti-inflammatories, anti-infectives, or other therapeutic, prophylactic, or diagnostic agents that can be administered orally, especially when lower blood levels relative to tissue levels of agent are preferred. In the most preferred formulation, the composition contains tacrolimus-loaded ascorbyl palmitate gel microfibers containing nanostructures (“hydrogels”).
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: December 12, 2023
    Assignee: Alivio Therapeutics, Inc.
    Inventors: Derek G. Van der Poll, Dominick J. Blasioli, Gregory T. Zugates
  • Patent number: 11841310
    Abstract: In one example, a flow cell includes a substrate, an electrode positioned on the substrate, and a patterned material positioned on the electrode. In this example, the patterned material includes depressions separated by interstitial regions, and a functionalized surface of the electrode is exposed at each of the depressions. In this example, the flow cell further includes a primer grafted to the functionalized surface in each of the depressions. In another example, a flow cell includes a substrate and a patterned electrode positioned on the substrate. In this other example, the patterned electrode includes depressions separated by interstitial regions, and a functionalized surface of the substrate exposed at each of the depressions. In this other example, a primer is grafted to the functionalized surface in each of the depressions.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: December 12, 2023
    Assignee: Illumina, Inc.
    Inventors: Hayden Black, Brian D. Mather
  • Patent number: 11838873
    Abstract: Systems, methods, apparatuses, and computer program products for altitude-aware energy saving. The method may include receiving, from a network element, information including a coupling loss change or a reduced transmit power command. The method may also include controlling an uplink transmission based on the received information.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: December 5, 2023
    Assignee: NOKIA TECHNOLOGIES OY
    Inventors: Gilsoo Lee, Rapeepat Ratasuk, Tzu-Chung Hsieh, Shahzada Basharat Rasool, Athul Prasad
  • Patent number: 11830190
    Abstract: Techniques are for detecting presence of a problematic cellular entity in a target. In an example, using an analysis model, a fluorescence-based image is analyzed. The analysis model is trained using a number of reference fluorescence-based images for detecting the presence of problematic cellular entities in targets. Based on the analysis, a problematic cellular entity present in the target is detected. To perform the detection, the analysis model is trained to differentiate between the fluorescence in the fluorescence-based image emerging from the problematic cellular entity and the fluorescence in the fluorescence-based image emerging from regions other than the problematic cellular entity.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: November 28, 2023
    Assignee: ADIUVO DIAGNOSTICS PRIVATE LIMITED
    Inventors: Bala Pesala, Geethanjali Radhakrishnan, Bikki Kumar Sha, John King
  • Patent number: 11828654
    Abstract: A spectroscopic analyzer includes: an irradiator that irradiates a target measurement object with lights of a plurality of different wavelengths sequentially as a pre-irradiation, and, after the pre-irradiation, further irradiates the target measurement object with lights of a plurality of different wavelengths sequentially as a measurement-irradiation; a detector that, during the measurement-irradiation, detects reflected light, transmitted light, or a transmitted reflected light from the target measurement object at each of the plurality of different wavelengths of the measurement-irradiation and that outputs absorbance spectral data; a data analyzer that analyzes the absorbance spectral data; and a result display that displays analysis results related to components of the target measurement object.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: November 28, 2023
    Inventor: Roumiana Tsenkova
  • Patent number: 11821899
    Abstract: Indirect ELISAs to detect exposure to Felis catus gammaherpesvirus 1 (FcaGHV1) in domestic cats. These ELISAs detect feline serum antibodies to ORF52 and ORF38 of FcaGHV1. The ELISA assays are sensitive, specific, and adaptable for scale up use in high throughput diagnostics.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: November 21, 2023
    Assignee: Colorado State University Research Foundation
    Inventors: Susan VandeWoude, Kathryn R. Stutzman-Rodriguez, Ryan M. Troyer
  • Patent number: 11808700
    Abstract: Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: November 7, 2023
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Benjamin Cipriany, Faisal R. Ahmad, Joseph D. Clark, Daniel B. Frier, Michael Ferrigno, Mel Davey, Tom Thurston, Brett J. Gyarfas, Todd Rearick, Jeremy Christopher Jordan
  • Patent number: 11808688
    Abstract: The present relates to a measurement device (1) for the detection and/or measurement of particles in a fluid, the measurement device comprising a fluid source (11) for producing a flow of fluid (111) along a fluid flow path, a first laser source (12) positioned for emitting a first laser beam (120) of laser light in a measurement volume of the fluid flow path for light scattering; a scattered light detecting means (13) for detecting a presence of a particle in the fluid flow path through detection and measurement of laser beam light scattered on different angles by said particle, wherein it further comprises a second laser source (14) positioned for emitting a second laser beam (140) of laser light in said measurement volume of the fluid flow path for Raman and fluorescence excitation; a Raman and fluorescence detecting means (15) for detecting a Raman scattering signal emitted by the fluid and a Fluorescence signal emitted by said particle upon excitation by said second laser beam (140).
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: November 7, 2023
    Assignee: Plair, SA
    Inventors: Denis Kiselev, Fabio Capela
  • Patent number: 11802305
    Abstract: A process for analysing epigenetically active regions of the genome.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: October 31, 2023
    Assignee: Oxford Biodynamics PLC
    Inventors: Alexandre Akoulitchev, Ewan Hunter, Aroul Ramadass
  • Patent number: 11801257
    Abstract: A composition and method for activating immune cells ex-vivo, or inducing an immune response in a subject including a composition comprising at least one chiral cationic lipid. The chiral cationic lipid in one embodiment comprises a nonsteroidal cationic lipid having a structure represented by formula (I); wherein in R1 is a quaternary ammonium group, Y1 is a space chosen from a hydrocarbon chain, an ester, a ketone, and a peptide, C* is a chiral carbon, R2 and R3 are independently chosen from a saturated fatty acid, an unsaturated fatty acid, an ester-linked hydrocarbon, phosphor-diesters, and combination thereof.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: October 31, 2023
    Assignee: PDS BIOTECHNOLOGY CORPORATION
    Inventors: Elizabeth Ann Vasievich, Weihsu Claire Chen, Kenya N. Toney Johnson, Gregory Conn, Frank Bedu-Addo, Leaf Huang
  • Patent number: 11802867
    Abstract: A measurement method and a measurement reagent for cardiac troponin which enable accurate measurement of the amount of cardiac troponin contained in a sample irrespective of the type of the sample and the presence or absence of other components are disclosed. The measurement method for cardiac troponin, wherein cardiac troponin in a sample separated from a body is measured by an immunoassay, includes a pretreatment step of mixing the sample separated from a body with a pretreatment liquid containing one or both of a surfactant and an acidifier. The reagent for immunoassay of cardiac troponin includes a pretreatment liquid containing one or both of a surfactant and an acidifier.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: October 31, 2023
    Assignee: FUJIREBIO INC.
    Inventors: Mizuho Sakaki, Yoshiyuki Kitamura, Shintaro Yagi, Katsumi Aoyagi
  • Patent number: 11802868
    Abstract: A method for providing variable function medical tests, comprising providing by a mobile device application a plurality of selectable medical test functions, receiving information from the mobile device application regarding test results from a test performed using a testing device, wherein the testing device includes an alignment target disposed on the testing device and a plurality of immunoassay test strips receiving at the server an image of the testing device from the mobile device application, determining by the server RGB values for a plurality of pixels of the image, normalizing by the server the RGB values into a single value, comparing by the server the single value to a control value stored on the server, and providing by the server a risk indicator, wherein the risk indicator indicates a likelihood of a presence of a medical condition.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: October 31, 2023
    Assignee: RELIANT IMMUNE DIAGNOSTICS, INC.
    Inventors: Jovan Hutton Pulitzer, Henry Joseph Legere, III
  • Patent number: 11795239
    Abstract: The invention provides novel compounds, reagents, systems, and methods for detecting a metabolite related to a NRTI in a biological sample, and use thereof in monitoring adherence to pre-exposure prophylaxis or anti-retroviral treatment. Such reagents comprise NRTI derivatives, analogs, NRTI derivatives conjugates, along with antibodies directed to same, which are useful for anti-body-based methods, such as a lateral flow immunoassay and other point of care devices.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: October 24, 2023
    Assignee: OraSure Technologies, Inc.
    Inventors: Giffin Daughtridge, Keith Kardos
  • Patent number: 11796548
    Abstract: Methods are provided herein utilizing a stable cell line capable of efficient infection by African swine fever virus (ASFV) and also provides for the detection of the presence of virus in samples applied to the cells. Detection of the virus by means such as red blood cell rosetting is a surprising result given that the cell line is derived from African green monkeys. This cell line provides a marked improvement over the currently available testing strategies.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: October 24, 2023
    Assignee: The United States of America, as represented by The Secretary of Agriculture
    Inventors: Douglas P. Gladue, Ayushi Rai, Manuel V. Borca
  • Patent number: 11783876
    Abstract: Methods, systems, and devices for a multi-port storage-class memory interface are described. A memory controller of the storage-class memory subsystem may receive, from a host device, a request associated with host addresses. The memory controller may generate interleaved addresses with a low latency based on the host addresses. The interleaved addresses parallelize processing of the request utilizing a set of memory media ports. Each memory media port of the set of memory media port may operate independent of each other to obtain a desired aggregated data transfer rate and a memory capacity. The interleaved address may leave no gaps in memory space. The memory controller may control a wear-leveling operation to distribute access operations across one or more zones of the memory media port.
    Type: Grant
    Filed: March 9, 2022
    Date of Patent: October 10, 2023
    Assignee: Micron Technology, Inc.
    Inventor: Joseph Thomas Pawlowski
  • Patent number: 11772095
    Abstract: A microfluidic routing device for routing objects of interest in a microfluidic flow includes a substrate; a first layer provided on the substrate, in which the first layer forms a bottom wall of a microfluidic channel. At least two holes through the first layer form respectively an inlet and an outlet for the microfluidic channel The microfluidic routing device further includes a second layer spaced away from the first layer, in which the second layer forms a top wall of the microfluidic channel. The second layer is configured to transmit an optical signal from the microfluidic channel. The microfluidic routing device includes an actuator for actuating the objects of interest in a sorting junction of the microfluidic channel.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 3, 2023
    Assignee: IMEC VZW
    Inventors: Chengxun Liu, Bivragh Majeed, Abdulkadir Yurt
  • Patent number: 11773443
    Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: October 3, 2023
    Assignee: EUROFINS LIFECODEXX GMBH
    Inventors: Sebastian Gromminger, Wera Hofmann, Hamed Said
  • Patent number: 11768209
    Abstract: A measurement method and a measurement reagent for thyroglobulin, which enable measurement of a more accurate amount of thyroglobulin by a single test without being influenced by interference of anti-thyroglobulin antibody, are disclosed. The measurement method for thyroglobulin, wherein thyroglobulin in a sample separated from a body is measured by an immunoassay, includes a pretreatment step of mixing the sample separated from a body with a pretreatment liquid containing one or both of a surfactant and an acidifier. The reagent for immunoassay of thyroglobulin includes a pretreatment liquid containing one or both of a surfactant and an acidifier.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: September 26, 2023
    Assignee: FUJIREBIO INC.
    Inventors: Kosuke Yamamoto, Yoshiyuki Kitamura, Shintaro Yagi, Katsumi Aoyagi
  • Patent number: 11761024
    Abstract: A system that indicates the presence or absence of microorganisms in fluid food products. The system has a bottle for receiving sample to be tested. The bottle has a sensor that will monitor and detect changes in at least one sample parameter, but no additives that contain nutrients that support microbial growth. The bottle is placed in an incubator and the sensor in the bottle is monitored for changes. The incubator is programed so that, if the sensor detects that the value of the monitored parameter has reached a certain value, then the sample is determined to be positive for microbial growth.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: September 19, 2023
    Assignee: BECTON DICKINSON HOLDINGS PTE LTD.
    Inventors: Xiao Li, Yan Zhang, Jianwei Liu
  • Patent number: 11759102
    Abstract: This disclosure provides a method for determining the likelihood of being at or beyond a certain rate and/or risk of visual field progression (VFP) of a user, that may include measuring ocular biomechanical properties (OBP) through a continuous-wear sensor placed on or implanted in the eye; recording the user's ocular biomechanical properties in the form of at least one OBP time series plot in a recorder, a processing step wherein at least one of a plurality of OBP parameters are extracted from the recorded OBP time series plot; a calculation step wherein the at least one of a plurality of OBP parameters are associated to VFP, and a determining step wherein one determines whether the visual field progression is at or beyond a certain VFP threshold and/or the probability that the said visual field progression is comprised within a specific range.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: September 19, 2023
    Assignee: Sensimed SA
    Inventors: Mario Schlund, Thierry Varidel, Raphael Fritschi, Carlos Gustavo De Moraes
  • Patent number: 11761029
    Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: September 19, 2023
    Assignee: MAMMOTH BIOSCIENCES, INC.
    Inventors: Janice Sha Chen, Ashley Tehranchi, Andrew Besancon Lane, James Paul Broughton, Lucas Benjamin Harrington, Maria-Nefeli Tsaloglou, Xin Miao, Clare Louise Fasching, Jasmeet Singh, Pedro Patrick Draper Galarza
  • Patent number: 11754565
    Abstract: The present invention relates to a method of quantifying the amount of Mock Virus Particles (MVP) removed from a solution as a result of processing that solution through a purification technique. This method involves the steps of adding MVP to a solution, processing the solution through a purification technique, quantifying the amount of MVP removed from the solution. The present invention also relates to a kit that can be used in conjunction with the method. This kit will comprise at least one stock solution of MVP and at least one quantification solution.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: September 12, 2023
    Assignee: MOCKV SOLUTIONS LLC
    Inventors: David Cetlin, Arun Dhar
  • Patent number: 11739125
    Abstract: The present invention relates to an mRNA sequence, comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory syncytial virus (RSV) or a fragment, variant or derivative thereof. Additionally the present invention relates to a composition comprising a plurality of mRNA sequences comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory syncytial virus (RSV) or a fragment, variant or derivative thereof. Furthermore it also discloses the use of the mRNA sequence or the composition comprising a plurality of mRNA sequences for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the prophylaxis or treatment of RSV infections Respiratory syncytial virus (RSV) infections. The present invention further describes a method of treatment or prophylaxis of RSV infections using the mRNA sequence.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: August 29, 2023
    Assignee: Cure Vac SE
    Inventors: Thomas Kramps, Margit Schnee, Daniel Voss, Benjamin Petsch
  • Patent number: 11732259
    Abstract: Oligonucleotide analogues conjugated to carrier peptides are provided. The disclosed compounds are useful for the treatment of various diseases, for example diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: August 22, 2023
    Assignee: SAREPTA THERAPEUTICS, INC.
    Inventor: Gunnar J. Hanson
  • Patent number: 11728009
    Abstract: The disclosure provides methods and systems for designing and synthesizing probes to capture a representative sample of genomic variants of a target genome from a sample. The methods include providing a multiple sequence alignment (MSA), designing a plurality of representative subsequences, and optionally synthesizing a nucleic acid probe. The designing step can comprise designating a plurality of intervals in the MSA, shifting start positions for each MSA subset, clustering the aligned subsequences within each adjusted subset, and determining a representative sequence for each reduced MSA subset. The disclosure also encompasses methods of isolating a plurality of nucleic acid variants of a targeted genomic subregion from a sample using the disclosed probe design, as well as the probe compositions themselves.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: August 15, 2023
    Assignee: FUSION GENOMICS CORPORATION
    Inventors: Shing H. Zhan, Brian S. Kwok, Mohammad A. Qadir
  • Patent number: 11723922
    Abstract: The present invention relates to CXCR6-transduced (a) T cell(s) such as (a) CD8+ T cell(s), (a) CD4+ T cell(s), (a) CD3+ T cell(s), (a) ?? T cell(s) or (a) natural killer (NK) T cell(s) for targeted tumor therapy, nucleic acid sequences, vectors capable of transducing such (a) T cell(s), (a) transduced T cell(s) carrying the nucleic acid sequences or vectors of the present invention, methods and kits comprising the nucleic acid sequences or vectors of the present invention. The invention also provides the use of said transduced T cell(s) in a method for the treatment of diseases characterized by CXCL16 overexpression as well as a pharmaceutical composition/medicament comprising (a) transduced T cell(s) expressing the CXCR6 for use in methods of treating diseases characterized by CXCL16 overexpression.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: August 15, 2023
    Assignee: LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
    Inventors: Sebastian Kobold, Stefan Endres, Moritz Rapp, Simon Grassmann
  • Patent number: 11718662
    Abstract: Disclosed is a method of diagnosing multiple sclerosis (MS), wherein a blood sample from a patient is incubated with a DNA-replication associated (REP) protein. The present invention relates to a DNA-replication-associated (Rep) protein for use in the diagnosis of multiple sclerosis (MS), wherein (a) an increased amount of Rep protein or fragments thereof in the sample as compared to an amount in a control sample; or an increased amount of anti-Rep protein antibodies with antigen in a sample from a subject as compared to an amount in a control sample correlates with a diagnosis of MS, wherein the Rep protein is MSBI1 Rep or MSBI2 Rep.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: August 8, 2023
    Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS
    Inventors: Harald Zur Hausen, Ethel-Michele De Villiers-Zur Hausen, Timo Bund, Sebastian Eilebrecht
  • Patent number: 11709163
    Abstract: The present invention discloses a method and its variations for simultaneous detection of antibodies against two or more antigens of human immunodeficiency virus (HIV) and determination of approximate time (duration) post HIV infection, thereby confirming the infection, and determination of recency of an HIV infection. The number of individuals with recently infected HIV in a given period may be further used to estimate incidence of HIV in a population.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: July 25, 2023
    Assignee: AVIOQ, INC.
    Inventors: Chamroen Chetty, Xing Xiang Li
  • Patent number: 11705229
    Abstract: A method and a device are for exchanging information regarding the clinical implications genomic variations. In an embodiment, the method includes receiving login-data of a user; evaluating the login-data received; establishing an encrypted data connection to the user after the evaluating indicates a positive evaluation of the login-data; saving, upon receiving a dataset in a context of a genomic variation, the dataset received in a memory, context-related with the genomic variation; and evaluating, upon a user request being received and connected with a search query for the genomic variation, a set of datasets from the memory, the datasets being context-related with the genomic variation and the set including the datasets that the user is authorized to receive, and sending the set of datasets to the user.
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: July 18, 2023
    Assignee: SIEMENS HEALTHCARE GMBH
    Inventors: Oliver Frings, Maximilian Wuerstle, Eugen Kubala, Dominik Neumann, Maximilian Weiss, Carsten Dietrich
  • Patent number: 11697844
    Abstract: The present disclose provides methods and systems for amplifying and quantifying nucleic acids and for detecting the presence or absence of a target in a sample. The methods and systems provided herein may utilize a device comprising a plurality of partitions separated from an external environment by a gas-permeable barrier. Certain methods disclosed herein involve subjecting nucleic acid molecules in the plurality of partitions to conditions sufficient to conduct nucleic acid amplification reactions. The nucleic acid molecules may be subjected to controlled heating in the plurality of partitions to generate data indicative of a melting point(s) of the nucleic acid molecules.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: July 11, 2023
    Assignee: Combinati Incorporated
    Inventors: Ju-Sung Hung, Megan Dueck, Andrew Zayac
  • Patent number: 11684918
    Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: June 27, 2023
    Assignee: INTEGENX, INC.
    Inventors: William D. Nielsen, Richard J. Belcinski, Gregory Bogdan, David Eberhart, Omar El-Sissi, Stevan B. Jovanovich, Michael Recknor, Ezra Van Gelder, David Wyrick
  • Patent number: 11688110
    Abstract: A method for evaluating image quality is provided. The method may include: obtaining an image, the image including a plurality of elements, each element of the plurality of elements being a pixel or voxel, each element having a gray level; determining, based on a maximum gray level of the plurality of elements, one or more thresholds for segmenting the image; determining one or more sub-images of a region of interest by segmenting, based on the one or more thresholds, the image; and determining, based on the one or more sub-images of the region of interest, a quality index for the image.
    Type: Grant
    Filed: February 21, 2022
    Date of Patent: June 27, 2023
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventor: Yi Wang
  • Patent number: 11686730
    Abstract: The present disclosure relates to methods and compositions, e.g., kits, for quantitatively detecting an antibody of a subject to an infectious organism. In some embodiments, the present disclosure provides for methods and compositions, e.g., kits, for quantitatively detecting a human antibody to SARS-CoV-2 polypeptide or S (spike) polypeptide. Certain applications and uses of the present methods and compositions, e.g., kits, are also provided.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: June 27, 2023
    Assignee: Quanterix Corporation
    Inventors: Andrew Ball, Lei Chang, Syrena Fernandes, Joe Johnson, Jeremy Lambert, Dawn Mattoon, Tatiana Plavina, David Wilson
  • Patent number: 11684660
    Abstract: Disclosed are compositions related to synthetic PD-1 peptides, chimeric PD-1 peptides, anti-PD-1 antibodies and methods of treating cancers, autoimmune diseases, and Alzheimer's disease using said peptides or antibodies.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: June 27, 2023
    Assignees: OHIO STATE INNOVATION FOUNDATION, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Pravin T. P. Kaumaya, Tanios Bekaii-Saab
  • Patent number: 11680084
    Abstract: The invention relates to polynucleotides comprising the sequence of a flavivirus preceded by a sequence encoding an N terminal part of a flavivirus Capsid protein, an immunogenic protein, or a part thereof comprising a an immunogenic peptide, and a 2A cleaving peptide, and to the virus encoded by such sequences. The invention further relates to the use of such polynucleotides and viruses as vaccines.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: June 20, 2023
    Assignee: KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Robbert Boudewijns, Kai Dallmeier, Johan Neyts
  • Patent number: 11680945
    Abstract: A test element for an assay includes: a cartridge having a housing which includes a priming pad capable of containing a liquid fluid, a wash port having an opening in the housing, and an opening for directly or indirectly applying a sample; and an assay device positioned within the cartridge in fluid communication with the wash port containing an analytical reagent.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: June 20, 2023
    Assignee: Ortho Clinical Diagnostics, Inc.
    Inventor: Raymond F. Jakubowicz