Parasite Or Protozoa Patents (Class 435/7.22)
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Patent number: 7993862Abstract: Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a mammalian sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, whipworm, and heartworm. Confirmation of the presence or absence of roundworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.Type: GrantFiled: May 18, 2009Date of Patent: August 9, 2011Assignees: IDEXX Laboratories, Inc., Divergence, Inc.Inventors: David Allen Elsemore, Laurie A. Flynn, Michael Crawford
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Patent number: 7993860Abstract: The present invention relates to new polypeptides recognized by anti-Trichinella antibodies. The invention also relates to the use of said polypeptides for the detection of anti-Trichinella antibodies and for the prevention of trichinellosis.Type: GrantFiled: February 7, 2007Date of Patent: August 9, 2011Assignees: Institut National de la Recherche Agronomique, Agence Francaise de Securite Sanitaire des Aliments, Jillin UniversityInventors: Pascal Boireau, Mingyuan Liu, Baoquan Fu, Danielle Le Rhun, Céline Bahuon, Isabelle Vallee, Franck Le Guerhier, Romel Hernandez Bello, Xiuping Wu
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Patent number: 7993861Abstract: Methods, devices, kits and compositions for detecting the presence or absence of whipworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of whipworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, roundworm, and heartworm. Confirmation of the presence or absence of whipworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.Type: GrantFiled: May 18, 2009Date of Patent: August 9, 2011Assignees: IDEXX Laboratories, Inc., Divergence, Inc.Inventors: David Allen Elsemore, Laurie A. Flynn, Michael Crawford
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Patent number: 7972606Abstract: The present disclosure relates to T24 nucleic acid sequences, amino acid sequences, and antibodies. Methods for detecting and diagnosing Taenia solium infection in a subject using the T24 sequences and specific binding agents are also disclosed. The T24 sequences disclosed herein can be formulated into a pharmaceutical composition for administration to a subject. For example, the disclosed T24 polypeptides can also be administered to a subject to stimulate an immune response in the subject, thereby protecting the subject against T. solium infection.Type: GrantFiled: April 29, 2009Date of Patent: July 5, 2011Assignee: The United States of America as respresented by the Department of Health and Human ServicesInventors: Kathy Hancock, Fatima Williams Whitfield, Melinda L. Yushak, Sowmya Pattabhi, Victor C.W. Tsang
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Patent number: 7972871Abstract: Disclosed is a testing device and methods for the identification of an analyte of interest in a sample. In a preferred embodiment, the testing device includes a front panel having at least one sample application aperture; a rear panel having at least one solvent application aperture; a sample collection matrix disposed between the rear panel and the front panel, the sample collection matrix being in communication with the sample and solvent application apertures of the front and rear panels; and at least one insertable test strip containing a reagent enabling detection of the analyte of interest.Type: GrantFiled: March 12, 2010Date of Patent: July 5, 2011Assignee: Enterix, Inc.Inventor: Howard Milne Chandler
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Patent number: 7964366Abstract: The invention provides methods and compositions for the detection of Ehrlichia chaffeensis.Type: GrantFiled: September 19, 2008Date of Patent: June 21, 2011Assignee: IDEXX Laboratories, Inc.Inventors: Thomas Patrick O'Connor, Jr., Eugene Regis Krah, III, Jill M. Saucier
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Patent number: 7951547Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.Type: GrantFiled: May 18, 2009Date of Patent: May 31, 2011Assignees: Idexx Laboratories, Inc., Divergence, Inc.Inventors: David Allen Elsemore, Jinming Geng, Laurie A. Flynn, Michael Crawford
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Publication number: 20110117107Abstract: Biomarkers for predicting the severity of malaria and methods for their detection are disclosed. In one aspect, the present application discloses CXCL4, CXCL10, VEGF, PGDF, IL-1Ra, IL-8, MIP-1?, sFas, Fas-L, sTNF-R2, and sTNF-R1 as biomarkers for the severity of malaria. In another aspect, the present application discloses a method for determining the severity of malaria and predicting mortality due to cerebral malaria. The method comprises the detection of the biomarkers CXCL4 and/or CXCL10 and at least one more biomarker and determining the severity of malaria and predicting mortality due to cerebral malaria based upon the ratio of expression of the biomarkers in the subject versus the expression of the biomarkers in a control.Type: ApplicationFiled: December 2, 2010Publication date: May 19, 2011Applicant: MOREHOUSE SCHOOL OF MEDICINEInventors: Jonathan K. Stiles, James W. Lillard, Henry B. Armatei Armah, Nana Otoo Wilson, Venkatachalam Udhayakumar
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Publication number: 20110098326Abstract: Novel 18F-labeled thiazole derivatives useful for imaging of metabotropic glutamate subtype 5 receptors (mGluR5) in living mammalian brain are disclosed herein. Also disclosed herein is a synthetic method for making the claimed thiazole derivatives under thermal heating or microwave conditions for aryl thioethers that provides the compounds in high yield. Imaging methods in which the claimed 18F-labeled thiazole derivatives are used as imaging agents are also disclosed. Halogen substituted thiazole derivative disclosed herein are also useful as therapeutic agents. Methods of treating mGluR5 mediated disorders with certain halogen substituted thiazole derivatives are disclosed.Type: ApplicationFiled: October 26, 2009Publication date: April 28, 2011Inventors: Victor W. Pike, Fabrice G. Simeon
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Publication number: 20110081666Abstract: The present invention is directed to antibodies and binding fragments thereof, which bind with high affinity and specificity to human P-selectin glycoprotein ligand 1 (PSGL-1) and which block both selectin and chemokine binding to PSGL-1 expressed on leukocytes, lymphocytes and endothelial cells and thus which inhibit migration and/or rolling of these cells and to methods for screening for inhibitory compounds including such antibodies and binding fragments thereof and to methods of therapeutic use thereof.Type: ApplicationFiled: November 15, 2010Publication date: April 7, 2011Inventors: RICHARD ALVAREZ, SCOTT ROLLINS
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Patent number: 7914998Abstract: The present invention features methods of identifying modulators of longevity. Also featured are organisms, cell systems and compositions for performing those methods. Further featured are therapeutic methods for the use of modulators identified according to said methodologies.Type: GrantFiled: March 29, 2004Date of Patent: March 29, 2011Assignee: University of MassachusettsInventors: Heidi A. Tissenbaum, Christian Grove, Nenad Svrzikapa, Seung Wook Oh, Melissa Grabowski, Yamei Wang
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Patent number: 7910063Abstract: A device for detection of magnetic permeability ? or, alternatively, relative magnetic permeability ?r or, alternatively, relative magnetic susceptibility (?r?1) of a sample, wherein said device contains a sample chamber and at least two coils, one coil surrounding said sample chamber and one coil placed so as to be in thermal contact by being physically connected to the material which constitutes the sample chamber, but without surrounding the cavity of the sample chamber, said sample chamber having at least one opening for introduction of a sample or a sample container holding a sample, said device also provided with an electronic circuit which measures the difference in inductance between the two coils.Type: GrantFiled: March 7, 2003Date of Patent: March 22, 2011Assignee: Lifeassays ABInventor: Dario Kriz
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Publication number: 20110039256Abstract: A method for detecting the presence of a diagnostic moiety indicative of exposure to an infectious organism in a biological sample taken from a human or animal, said method comprising; (a) adding to said sample a first fluorescently labelled reagent which binds said diagnostic moiety, and a second fluorescently labelled reagent which either binds said diagnostic moiety in addition to said first fluorescently labelled reagent, or which binds the first fluorescently labelled reagent or a complex comprising the first fluorescently labelled reagent in competition to the said diagnostic moiety, wherein a label on one of the first or second fluorescently labelled reagent acts as a fluorescent energy donor compound and wherein the other of the first or second fluorescently labelled reagent acts as a fluorescent energy acceptor compound which is able to accept fluorescent energy from said donor compound; (b) exciting the fluorescent energy donor compound by illuminating with light of a wavelength which is absorbed byType: ApplicationFiled: March 27, 2009Publication date: February 17, 2011Applicant: THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD, & RURAL AFFAIRSInventor: John McGiven
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Patent number: 7846675Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulation sand production of immune globulins for passive prophylaxis and immunity in subjects.Type: GrantFiled: December 27, 2007Date of Patent: December 7, 2010Assignee: The United States of America as represented by the Secretary of the NavyInventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
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Publication number: 20100279319Abstract: The detection of PfHRP II in saliva offers a practical, cost-effective alternative to PfHRP II detection in blood as a means for diagnosis of malaria. Collection of saliva is non-invasive, simple, safe, stress free, painless and can be accomplished in primitive settings. The use of Malaria Antigen ELISA kits (CELISA, Cellabs, Australia) used in accord with known procedures for testing blood samples.Type: ApplicationFiled: April 29, 2009Publication date: November 4, 2010Inventor: Jonathan K. Stiles
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Publication number: 20100233731Abstract: This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive against antigens or markers as they appear in the excrement or other ectoparasitic materials. Such markers or antigens may be produced by the ectoparasite itself or may have been introduced into the ectoparasite because of its blood feeding activity. The method of the present invention comprises collecting from the enclosure or area, a sample comprising environmental dust or materials and subjecting the sample to tests for detecting the presence of hematophagous ectoparasitic markers, host markers or both.Type: ApplicationFiled: May 28, 2010Publication date: September 16, 2010Inventor: Nathan L. Smith
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Patent number: 7790186Abstract: Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any strain of P. vivax.Type: GrantFiled: January 18, 2006Date of Patent: September 7, 2010Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Anjali Yadava, Christian F. Ockenhouse
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Patent number: 7771660Abstract: Methods for identifying a biological particle in a sample medium include generating an Electrophoretic Quasi-elastic Light Scattering (EQELS) spectrum for the biological particle in the sample medium. The EQELS spectrum is compared to a reference database comprising a plurality of spectra, and each of the plurality of spectra correspond to an EQELS spectrum for one of a plurality of known biological particles. The biological particle in the sample medium is identified from the comparison.Type: GrantFiled: May 3, 2005Date of Patent: August 10, 2010Assignee: University of North Carolina at Chapel HillInventor: Don A. Gabriel
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Patent number: 7754155Abstract: A cell isolating device and method is provided to concentrate or isolate cells with specific characteristics from a mixture of different cell types. One embodiment may comprise two subtypes of antibodies that are directly conjugated to biotin (Abb) and conjugated to a fluorescent molecule (Abf). The conjugated antibodies (Abb+Abf) bind to the target cells in a mixed cell suspension. The cell suspension is then passed over an immobilized avidin or streptavidin substrate on a glass microscope slide. The biotinylated target cells adhere to the avidin/streptavidin substrate, while the unbound cells are washed off and collected in a wicking member. Captured cells on the avidin/streptavidin substrate may then be visualized directly using a fluorescent microscope or detected and enumerated via an on-board fluorescent detection device.Type: GrantFiled: September 18, 2002Date of Patent: July 13, 2010Inventors: Amelia A. Ross, Steve Bernstein
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Patent number: 7749717Abstract: The present invention relates to the diagnosis of Trypanosoma cruzi infection.Type: GrantFiled: October 19, 2006Date of Patent: July 6, 2010Assignee: Abbott LaboratoriesInventors: Dinesh O. Shah, Chi-Deu Chang, Gerald Schochetman, Kevin Y. Cheng
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Patent number: 7747395Abstract: The present invention provides the three-dimensional structure of human mitochondrial Homo sapiens peptide deformylase (HsPDF) protein, and HsPDF complexed to a binding compound, such as a PDF inhibitor. This crystallographic information will aid in the identification and development of novel binding compounds of HsPDF and other PDF family members which have anti-bacterial, anti-viral, anti-parasitical, anti-inflammatory, and/or anti-cancer activity.Type: GrantFiled: April 13, 2007Date of Patent: June 29, 2010Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: David A. Scheinberg, Sindy Noemi Escobar-Alvarez, Yehuda Goldgur, Yueming Li
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Patent number: 7740859Abstract: The present invention provides compounds and methods for the detection of anti-leishmanial antibodies in individuals suspected of infection with the protozoan parasite of the genus Leishmania, where the infectious agent is an Indian strain and similar or closely related to Indian Leishmania strains. The compounds provided include polypeptides as shown in SEQ ID NO: 5 or SEQ ID NO: 6 which are useful for the detection of anti-leishmanial antibodies in individuals where the immune responses are elicited against Leishmania species of Indian strains and similar or closely related to Indian Leishmania strains, the compounds are also useful as a vaccine and therapeutic agent to prevent and treat leishmaniasis. The present invention further provides a diagnostic kit consisting of antibody raised against polypeptides as shown in SEQ ID NO: 5 or SEQ ID NO: 6 for detecting leishmanial antigens.Type: GrantFiled: December 26, 2003Date of Patent: June 22, 2010Assignees: All India Institute of Medical Sciences, Division of Clinicial Microbiology, Department of Biotechnology, Department of Govt of IndiaInventors: Sarman Singh, Ramu Sivakumar
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Publication number: 20100151500Abstract: Methods, devices, kits and compositions for detecting the presence or absence of hookworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of hookworm in a fecal sample from a mammal that may also be infected with one or more of roundworm, whipworm, and heartworm. Confirmation of the presence or absence of hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.Type: ApplicationFiled: May 18, 2009Publication date: June 17, 2010Applicant: IDEXX LABORATORIES, INC.Inventors: Jinming Geng, David Allen Elsemore
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Patent number: 7727734Abstract: This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive against antigens or markers as they appear in the excrement or other ectoparasitic materials. Such markers or antigens may be produced by the ectoparasite itself or may have been introduced into the ectoparasite because of its blood feeding activity. The method of the present invention comprises collecting from the enclosure or area, a sample comprising environmental dust or materials and subjecting the sample to tests for detecting the presence of hematophagous ectoparasitic markers, host markers or both.Type: GrantFiled: July 27, 2006Date of Patent: June 1, 2010Assignee: CytoSignet, Inc.Inventor: Nathan L. Smith
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Patent number: 7718355Abstract: There is provided a method of detecting a pathogenic microorganism in real-time, using a modified flow-type surface plasmon resonance (SPR) biosensor, comprising the steps of: i) performing, in a batch-type, an immune reaction of a pathogenic microorganism and an antibody thereto; ii) selectively separating the pathogenic microorganism bound with the antibody; and iii) binding the pathogenic microorganism bound with the antibody on a surface of a chip of a flow-type SPR sensor system in real-time.Type: GrantFiled: December 28, 2006Date of Patent: May 18, 2010Assignee: Sungkyunkwan UniversityInventors: Sang-jun Sim, Chang-deok Kang
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Publication number: 20100120017Abstract: The present invention relates to a rapid immunochromatographic test device suitable to detect more than one target in a single assay at the same time, uses of said device for detecting diseases in a sample, a method for the production of said device as well as a kit comprising the device.Type: ApplicationFiled: December 6, 2007Publication date: May 13, 2010Inventors: Adnan Badwan, Murshed Abdel-Qader Mohammed
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Publication number: 20100120071Abstract: This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive against antigens or markers as they appear in the excrement or other ectoparasitic materials. Such markers or antigens may be produced by the ectoparasite itself or may have been introduced into the ectoparasite because of its blood feeding activity. The method of the present invention comprises collecting from the enclosure or area, a sample comprising environmental dust or materials and subjecting the sample to tests for detecting the presence of hematophagous ectoparasitic markers, host markers or both.Type: ApplicationFiled: July 27, 2006Publication date: May 13, 2010Inventor: Nathan L. Smith
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Publication number: 20100092520Abstract: Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was surprisingly found that the recombinant polypeptides contain an EGF-like domain at the C-terminus that is properly folded in the polypeptide.Type: ApplicationFiled: November 23, 2006Publication date: April 15, 2010Inventors: Shirley Longacre, Hannah Polson, Ronald Perraut, Farida Nato
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Patent number: 7695925Abstract: Compositions comprising fusion polypeptides of T. cruzi epitopes are provided, together with methods for the use of such compositions in the diagnosis of T. cruzi infection and in screening blood supplies. Diagnostic kits comprising such compositions are also provided.Type: GrantFiled: November 2, 2006Date of Patent: April 13, 2010Assignees: Inbios International, Inc., Infectious Disease Research InstituteInventors: Raymond L. Houghton, Steven G. Reed, Syamal Raychaudhuri
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Publication number: 20100068696Abstract: The present invention relates to methods for detecting or quantifying an analyte in a test sample including providing at least one test mixture including a test sample, at least one marker complex, wherein each marker complex includes a particle, a marker, and one member of a coupling group, a first binding material selected to bind to a portion of the analyte, a second binding material selected to bind with a portion of the analyte other than the portion of the analyte for which the first binding material is selected, analyte analog, and/or marker conjugate. The at least one test mixture is passed through a membrane. The amount of marker on the membrane is detected and correlated to the presence or amount of analyte in the test sample.Type: ApplicationFiled: November 10, 2006Publication date: March 18, 2010Applicant: Cornell Research Foundation, Inc.Inventor: Antje J. Baeumner
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Patent number: 7666612Abstract: A method for labeling acyl carrier protein (ACP) fusion proteins with a wide variety of different labels is disclosed. The method relies on the transfer of a label from a coenzyme A type substrate to an ACP fusion protein using a holo-acyl carrier protein synthase (ACPS) or a homologue thereof. The method allows detecting and manipulating the fusion protein, both in vitro and in vivo, by attaching molecules to the fusion proteins that introduce a new physical or chemical property to the fusion protein. Examples of such labels are, among others, spectroscopic probes or reporter molecules, affinity tags, molecules generating reactive radicals, cross-linkers, ligands mediating protein-protein interactions or molecules suitable for the immobilization of the fusion protein.Type: GrantFiled: May 19, 2004Date of Patent: February 23, 2010Assignee: EPFL-Ecole Polytechnique Federale De LausanneInventors: Kai Johnsson, Nathalie George
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Patent number: 7662575Abstract: This invention discloses methods for identifying Francisella tularensis vaccine candidates. It enables identification of novel vaccine candidates and quality assurance for vaccine batches, assessment of protection in vaccinates and identification of the infecting agent in vaccinates. Mice were first vaccinated with Brucella abortus O-polysaccharide (OPS) vaccine. These animals were then given 10 LD50s of F. tularensis live vaccine strain (LVS). Sixty percent (60%) of the vaccinated mice survived the multiple lethal doses. Sera were collected from these surviving mice and the antibodies were used to probe supernatant and cell lysates of live F. tularensis LVS cultures. Several F. tularensis components were identified only by the noted “survivor” antisera. Of these identified proteins, enzyme digestions and chemical oxidation suggest post-translational modifications of some proteins e.g. a 52 kDa glycoprotein, a 45 kDa lipoprotein and a 19 kDa nucleoprotein.Type: GrantFiled: October 31, 2007Date of Patent: February 16, 2010Assignee: Her Majesty the Queen in right of Canada, as represented by the Minister of National Defence of Her Majesty's Canadian GovernmentInventors: Christopher Sikora, Bradley Berger, John Cherwonogrodzky
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Publication number: 20100035234Abstract: The present invention is directed to methods, assays and compositions for implementing such methods and assays for assessing efficacy of individual components in multi-component vaccines and for assessing efficacy of a vaccine against a pathogen. In one aspect, the method of assessing efficacy of a vaccine against a pathogen is a quick assay that tests for an activity correlated with efficacy such as binding in an ELISA rather than requiring the time and expense of an assay that detects actual bactericidal activity. In another aspect, the method for testing the efficacy of an individual component in a multi-component vaccine includes obtaining an immune sample from a subject inoculated with the multi-component vaccine; blocking the portion of the immune sample that recognizes the individual component such as by addition of the individual component, and testing the efficacy of the immune sample to respond to the pathogen.Type: ApplicationFiled: May 19, 2009Publication date: February 11, 2010Applicant: Novartis AGInventors: John Donnelly, Ping Wu, George Santos, Marzia Monica Giuliani, William Andrews, Jie Chen
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Patent number: 7655427Abstract: The invention provides novel immunogenic proteins LigA and LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits.Type: GrantFiled: April 8, 2005Date of Patent: February 2, 2010Assignee: Cornell Research Foundation, Inc.Inventors: Yung-Fu Chang, Raghavan U. M. Palaniappan
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Publication number: 20090324582Abstract: The present invention discloses a process for simple and rapid detection and identification of molecular mimicry or mimic antigens or molecules existing in/on humans, animals and plants. The molecular mimicry can be related to infections, autoimmune diseases, cancers, obesity and other disorders. Therefore, novel methods for the diagnosis, prevention, and treatment of infections, autoimmune diseases, cancers, obesity and other disorders obtainable based on these mimic antigens or molecules can be developed. Furthermore, the present invention also reveals a new functional mechanism of vaccine and passive immunity and novel vaccines obtainable based on the new mechanism.Type: ApplicationFiled: August 17, 2007Publication date: December 31, 2009Inventor: Huiru Wang
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Publication number: 20090298195Abstract: Method for engineering an immunoglobulin comprising at least one modification in a structural loop region of said immunoglobulin and determining the binding of said immunoglobulin to an epitope of an antigen, wherein the unmodified immunoglobulin does not significantly bind to said epitope, comprising the steps of:—providing a nucleic acid encoding an immunoglobulin comprising at least one structural loop region,—modifying at least one nucleotide residue of at least one of said structural loop regions,—transferring said modified nucleic acid in an expression system,—expressing said modified immunoglobulin,—contacting the expressed modified immunoglobulin with an epitope, and—determining whether said modified immunoglobulin binds to said epitope, as well as modified immunoglobulins.Type: ApplicationFiled: January 5, 2006Publication date: December 3, 2009Inventors: Florian Rüker, Gordana Wozniak-Knopp
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Patent number: 7626017Abstract: Methods for cell lysis and purification of biological materials, involving subjecting a sample to high pressure. Also featured is an apparatus for practicing the methods.Type: GrantFiled: August 16, 2004Date of Patent: December 1, 2009Assignee: Pressure Biosciences, Inc.Inventors: James A. Laugharn, Jr., Robert A. Hess, Feng Tao
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Publication number: 20090286231Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.Type: ApplicationFiled: May 18, 2009Publication date: November 19, 2009Applicants: IDEXX LABORATORIES, INC., DIVERGENCE, INC.Inventors: David Allen Elsemore, Jinming Geng, Laurie A. Flynn, Michael Crawford
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Publication number: 20090286230Abstract: Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, whipworm, and heartworm. Confirmation of the presence or absence of roundworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.Type: ApplicationFiled: May 18, 2009Publication date: November 19, 2009Applicants: IDEXX LABORATORIES, INC., DIVERGENCE, INC.Inventors: David Allen Elsemore, Laurie A. Flynn, Michael Crawford
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Publication number: 20090286227Abstract: Methods, devices, kits and compositions for detecting the presence or absence of whipworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of whipworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, roundworm, and heartworm. Confirmation of the presence or absence of whipworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.Type: ApplicationFiled: May 18, 2009Publication date: November 19, 2009Applicants: IDEXX LABORATORIES, INC., DIVERGENCE, INC.Inventors: David Allen Elsemore, Laurie A. Flynn, Michael Crawford
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Publication number: 20090286228Abstract: Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a mammalian sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, whipworm, and heartworm. Confirmation of the presence or absence of roundworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.Type: ApplicationFiled: May 18, 2009Publication date: November 19, 2009Applicants: IDEXX LABORATORIES, INC., DIVERGENCE, INC.Inventors: David Allen Elsemore, Laurie A. Flynn, Michael Crawford
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Patent number: 7611853Abstract: Malarial parasite Plasmodium falciparum is responsible for the most severe form of malaria in humans, causing about 2 million deaths every year. Lack of effective vaccines and emergence of drug-resistant strains necessitate the need of novel drug targets to treat the disease. The present invention describes a novel assay method of identifying candidate compounds as anti-malarials based on the property of binding to plasmodial parasite 90 kDa heat shock protein.Type: GrantFiled: December 1, 2003Date of Patent: November 3, 2009Assignee: Indian Institute of ScienceInventors: Tatu Utpal, Pavithra Soundara Raghavan, Banumathy Gowrishankar
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Publication number: 20090226941Abstract: The present invention is directed to diagnostic devices and methods for detecting Trichomonas infections.Type: ApplicationFiled: April 7, 2009Publication date: September 10, 2009Applicant: KIMBERLY-CLARK WORLDWIDE, INC.Inventors: Ilona F. Weart, Shu-Paing Yang
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Patent number: 7582415Abstract: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.Type: GrantFiled: September 6, 2002Date of Patent: September 1, 2009Inventor: Don Straus
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Publication number: 20090215086Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying babesia status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with babesia or not infected with babesia. The biomarkers can be detected by SELDI mass spectrometry.Type: ApplicationFiled: December 12, 2006Publication date: August 27, 2009Inventors: Momar Ndao, Brian Ward, Peter Krause, Mark W. Duncan, Mike Edwards, Terence William Spithill
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Publication number: 20090215696Abstract: Recombinant proteins have been developed for the detection of Toxoplasma gondii oocyst proteins for example in biological fluids. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.Type: ApplicationFiled: May 6, 2009Publication date: August 27, 2009Inventors: Dolores E. Hill, Dante S. Zarlenga, Cathleen Coss, Jitender P. Dubey
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Publication number: 20090215087Abstract: Recombinant proteins have been developed for the detection of Toxoplasma gondii oocyst proteins for example in biological fluids. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.Type: ApplicationFiled: May 6, 2009Publication date: August 27, 2009Inventors: Dolores E. Hill, Dante S. Zarlenga, Cathleen Coss, Jitender P. Dubey
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Publication number: 20090209470Abstract: The present disclosure relates to T24 nucleic acid sequences, amino acid sequences, and antibodies. Methods for detecting and diagnosing Taenia solium infection in a subject using the T24 sequences and specific binding agents are also disclosed. The T24 sequences disclosed herein can be formulated into a pharmaceutical composition for administration to a subject. For example, the disclosed T24 polypeptides can also be administered to a subject to stimulate an immune response in the subject, thereby protecting the subject against T. solium infection.Type: ApplicationFiled: April 29, 2009Publication date: August 20, 2009Inventors: Kathy Hancock, Fatima Williams Whitfield, Melinda L. Yushak, Sowmya Pattabhi, Victor C.W. Tsang
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Publication number: 20090208501Abstract: Chimeric molecules that include a pathogen recognition module derived from a pathogen binding domain of a pathogen recognition protein, e.g., a toll-like receptor (TLR), CD14, BPI, MD-2, scavenger receptors (SRs), surfactant proteins (SP), C-reactive protein (CRP), Mannan-binding lectin (MBL), or complement Clq globular binding domain, an optional linker, and an Fc portion of an antibody are described and are useful for, e.g., drug discovery and treatment of conditions related to TLR signaling.Type: ApplicationFiled: August 4, 2005Publication date: August 20, 2009Inventors: Alberto Visintin, Douglas T. Golenbock
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Publication number: 20090196884Abstract: The present invention relates to a synthetic antigenic sequence which represents a combination of epitope-containing sequences from the highly polymorphic block 2 repeat region of K1-type Plasmodium falciparum merozite surface antigen (MSP1) and fusion proteins containing that sequence in combination with additional epitope-containing sequences capable of inducing antibody and cellular immune responses to P.Type: ApplicationFiled: May 26, 2006Publication date: August 6, 2009Applicant: LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINEInventors: Kevin K. Tetteh, David J. Conway