Involving A Micro-organism Or Cell Membrane Bound Antigen Or Cell Membrane Bound Receptor Or Cell Membrane Bound Antibody Or Microbial Lysate Patents (Class 435/7.2)
  • Patent number: 11361953
    Abstract: Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: June 14, 2022
    Assignee: Quest Diagnostics Investments Incoporated
    Inventors: Darren Weber, Nigel Clarke
  • Patent number: 11316140
    Abstract: A display substrate, comprising a plurality of light emitting units of different colors, each of which comprises: an electron transport layer, a hole transport layer, a quantum-dot light emitting layer located between the electron transport layer and the hole transport layer; and a hydrophilicity and hydrophobicity variable layer, located between the electron transport layer and the quantum-dot light emitting layer and configured to undergo an exposure treatment to change hydrophilicity and hydrophobicity of sides of the hydrophilicity and hydrophobicity variable layer that are in contact with the electron transport layer and the quantum-dot light emitting layer.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: April 26, 2022
    Assignees: BEIJING BOE TECHNOLOGY DEVELOPMENT CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Aidi Zhang, Zhenqi Zhang
  • Patent number: 11293922
    Abstract: The present disclosure provides methods and lateral flow devices for detecting a plurality of target analytes in a liquid sample. In some implementations, the disclosed lateral flow device comprises a housing unit, a capillary flow bed, a sample-receiving zone, a buffer-receiving zone, and a capture zone. The device is configured to control the flow of the sample and reagent buffer in a sequential manner with minimal mixing. In some implementations, the disclosed method is capable of detecting a plurality of target analytes in an assay by applying the binding agents and the signaling agents in separate or sequential steps.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: April 5, 2022
    Assignee: Verax Biomedical Incorporated
    Inventors: Yli Remo Vallejo, Gregory M. Lawrence, Adam P. Lousararian, Lisa Shinefeld
  • Patent number: 11291992
    Abstract: A portable and completely self-contained apparatus(20) for detecting analyte and the methods of use thereof is described. The apparatus (20) includes a microfluidic cartridge driver unit (30), an optical inspection unit (32), and a control unit (28) and a power supply unit, which can run the binding and detection of the analyte without any fluidic interfaces to the instrument. The microfluidic cartridge driver unit (30) receives microfluidic cartridge (22) that holds a microarray and integrated microfluidic chip (24) for delivering the analyte to perform different process steps in the detection of analyte. A complete detection of analyte using the invention takes only a few minutes.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: April 5, 2022
    Assignee: Sanwa BioTech Ltd
    Inventors: Isabelle Cécile Angèle Dutry, Kin Sun Ip, Kelvin Chiu, Wai Lam William Yim, Yiu Ting Richard Lau
  • Patent number: 11274248
    Abstract: A lanthanoid-containing inorganic material fine particle having a function of converting a wavelength of light to a shorter wavelength, the lanthanoid-containing inorganic material fine particle including: a core particle; and a shell layer, the core particle containing a lanthanoid having a light-absorbing function and a lanthanoid having a light-emitting function, the shell layer including at least an outer shell containing a rare earth element, the total amount of the lanthanoid having a light-absorbing function and the lanthanoid having a light-emitting function in the outer shell being 2 mol % or less based on the amount of the rare earth element contained in the outer shell, the outer shell having a thickness of 2 to 20 nm, the core particle and the shell layer having no interface at a contact face to form a continuous body.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: March 15, 2022
    Assignee: SEKISUI CHEMICAL CO., LTD.
    Inventors: Taku Sasaki, Takeshi Wakiya, Kenji Oohashi
  • Patent number: 11266730
    Abstract: The invention provides methods of treating disease, such as hypercholesterolemia (e.g., by modulating serum lipids, such as cholesterol, low-density lipoproteins, high-density lipoproteins, and triglycerides) and hyperglycemia by administering Bacillus Calmette-Guerin (BCG). Methods of the invention also encompass the use of genomic, proteomic, and metabolomic analyses for determining the likelihood that a patient has disease or will respond to treatment (e.g., with BCG therapy), as well as for determining whether a patient previously administered BCG would benefit from BCG redosing.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: March 8, 2022
    Assignee: The General Hospital Corporation
    Inventor: Denise L. Faustman
  • Patent number: 11262287
    Abstract: Provided is a sample property detecting apparatus including: a wave source configured to irradiate a wave towards a sample; a detector configured to detect a laser speckle that is generated when the wave is multiple-scattered by the sample, at every time point that is set in advance; and a controller configured to obtain a temporal correlation that is a variation in the detected laser speckle according to time, and to detect properties of the sample in real-time based on the temporal correlation, wherein the detector detects the laser speckle between the sample and the detector or from a region in the detector.
    Type: Grant
    Filed: January 6, 2021
    Date of Patent: March 1, 2022
    Assignee: Korea Advanced Institute Of Science And Technology
    Inventors: YongKeun Park, JongHee Yoon, KyeoReh Lee, Young Dug Kim
  • Patent number: 11248052
    Abstract: The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing ?-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising ?-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: February 15, 2022
    Assignee: AMGEN INC.
    Inventors: Yang Li, Jennitte LeAnn Stevens, Chadwick Terence King, Ian Nevin Foltz, Gunasekaran Kannan, Junming Yie, Shaw-Fen Sylvia Hu
  • Patent number: 11237156
    Abstract: This invention relates to peptide microarrays, methods of generating peptide microarrays, and methods of identifying peptide binders using microarrays. More specifically, this invention relates to peptide microarrays, methods of generating peptide microarrays, and methods of identifying peptide binders using microarrays wherein the microarrays comprise cyclic peptides. The invention also relates to methods and compositions for detecting the formation of cyclized peptides from linear peptides on a microarray by contacting the microarray with a detectable protein. The cyclized peptides include tags that are activated upon cyclization, facilitating the detection of successful cyclization reactions. In additional aspects, the invention relates to developing fragmented peptide tags that, upon cyclization, bind to detectable proteins. Additionally, the invention relates to methods of generating linear and cyclic peptides subarrays on a microarray.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: February 1, 2022
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Lauren Goodrich, Jigar Patel, Eric Sullivan
  • Patent number: 11192934
    Abstract: The present invention relates, in part, to chimeric proteins which include the extracellular domain of V-set and immunoglobulin domain-containing protein 8 (VSIG8) and their use in the treatment of diseases, such as immunotherapies for cancer and/or inflammatory diseases.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: December 7, 2021
    Assignee: Shattuck Labs, Inc.
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva
  • Patent number: 11192933
    Abstract: The present invention relates, in part, to chimeric proteins which include the extracellular domain of V-set and immunoglobulin domain-containing protein 8 (VSIG8) and their use in the treatment of diseases, such as immunotherapies for cancer and/or inflammatory diseases.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: December 7, 2021
    Assignee: Shattuck Labs, Inc.
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva
  • Patent number: 11123442
    Abstract: A cell-penetrating peptide (CPP) comprising comprises a plurality of mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s where a plurality of the amino acids comprise a positively charged guanylurea unit with a small molecule fragment and each of the mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s comprising a drug attached through a linker. The CPP can be used for treating cancers.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: September 21, 2021
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventor: Joong Ho Moon
  • Patent number: 11111534
    Abstract: Provided are methods of nucleic acid sample preparation for analysis, including analysis using nanopore sequencing applications. In particular provided are methods that allow for the creation of circular and linear DNA samples that contain asymmetric ends to ligate different and desired adaptors to the end of the sample, methods to create single nucleic acid molecules that automatically form concatemers for higher sequencing throughput; methods to create multiple copies (temperature dependent, multi-primed, open-fold replication) of one original nucleic acid sample, or to create single nucleic acid molecules containing multiple copies of more than one original nucleic acid sample (concatemerized samples) for improved accuracy and throughput are described; and methods for improved modified base calling.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: September 7, 2021
    Assignee: Roche Sequencing Solutions, inc.
    Inventors: Randall Davis, Michael Dorwart, Janine Mok
  • Patent number: 11105820
    Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: August 31, 2021
    Assignees: University of Washington through its Center for Commercialization, Bloodworks
    Inventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
  • Patent number: 11098124
    Abstract: Disclosed is CD31shed for use as a molecular imaging target in the molecular imaging of an inflammatory condition. Administering the radiolabeled peptide P8RI as CD31shed ligand in different rat models of inflammation indeed showed that CD31shed is present on activated cells in a quantity allowing a detectable signal, whereas the noise signal corresponding to CD31shed present on activated circulating cells and on other organs or cells not involved in inflammation was little. Also disclosed is a labeled CD31shed ligand and the use thereof as a molecular imaging agent in the molecular imaging of an inflammatory condition. The molecular imaging of inflammatory sites particularly allows determining whether a subject suffers from or is at risk of having an inflammatory condition or is at risk of recurrence of an inflammatory condition after an anti-inflammatory treatment.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: August 24, 2021
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE PARIS, UNIVERSITE PARIS 13—PARIS NORD, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Sylvie Bay, Antonino Nicoletti, Dominique Le Guludec, Jonathan Vigne, Giuseppina Caligiuri
  • Patent number: 11067581
    Abstract: The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample comprising removing sialo-transferrin and selectively detecting or measuring asialo-transferrin in the biological sample.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: July 20, 2021
    Assignees: NSPC TECHNOLOGIES, LLC, RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Seok-Joon Kwon, Robert J. Linhardt, Jonathan S. Dordick, William J. Sonstein, Fuming Zhang
  • Patent number: 11066630
    Abstract: The present invention provides an integrated microphysiological device and fabrication methods thereof, as well as methods of use to perform biological assays.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: July 20, 2021
    Assignee: The Johns Hopkins University
    Inventors: Onur Kilic, Steven An, Andre Levchenko
  • Patent number: 10982263
    Abstract: A method for analyzing planar sample is provided. In some cases the method comprises: (a) labelling the planar sample with a capture agent that is linked to a nucleic acid, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the nucleic acid, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: April 20, 2021
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Nikolay Samusik, Garry P. Nolan, Yury Goltsev, David Robert McIlwain
  • Patent number: 10980853
    Abstract: The present invention provides a process for the preparation of a Crassocephalum crepidioides extract, and the extract prepared thereby. The present invention further relates to a pharmaceutical composition/combination comprising the Crassocephalum crepidioides extract. The use of the extract and the composition/combination comprising the extract in the prevention or treatment of cancer is also provided.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: April 20, 2021
    Assignee: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: Dai-Hua Tsai, Tzung Hsien Lai, Tsui Hsu Chan, Yuh Shan Chung, Li-Chuan Hsu
  • Patent number: 10981167
    Abstract: Embodiments disclosed herein are directed to microfluidic devices that allow for scalable on-chip screening of combinatorial libraries and methods of use thereof. Droplets comprising individual molecular species to be screened are loaded onto the microfluidic device. The droplets are labeled by methods known in the art, including but not limited to barcoding, such that the molecular species in each droplet can be uniquely identified. The device randomly sorts the droplets into individual microwells of an array of microwells designed to hold a certain number of individual droplets in order to derive combinations of the various molecular species. The paired droplets are then merged in parallel to form merged droplets in each microwell, thereby avoiding issues associated with single stream merging. Each microwell is then scanned, e.g., using microscopy, such as high content imaging microscopy, to detect the optical labels, thereby identifying the combination of molecular species in each microwell.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: April 20, 2021
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Paul Blainey, Anthony Kulesa, Jared Kehe
  • Patent number: 10973679
    Abstract: A condom for detection of STDs, including an interior condom surface having a control band and a test band, and an exterior condom surface that also has a control band and test band. Each test band allows binding and subsequent detection of STD antigens. A separate developing antibody produces a color change if bound to the antigen/antibody conjugate. The developing antibody may be present on the condom or applied separately after use.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: April 13, 2021
    Inventors: Adam Arreola, Cameron R. Pye
  • Patent number: 10946042
    Abstract: The present invention relates to compositions and methods that provide novel therapies in cancer. The invention includes a phagocytic cell modified with a repressor of signal regulatory protein-alpha (SIRP?) and bound to a targeting antibody to enhance phagocytic activity of the phagocytic cell toward tumor tissue. Methods of enhancing phagocytic activity and treating a tumor are also included.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: March 16, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Dennis E. Discher, Kyle R. Spinler, Cory Alvey
  • Patent number: 10925919
    Abstract: Provided is a material effective for improving the activity of nerves in the brain or for preventing or ameliorating brain dysfunction. An agent for activating astrocyte glucose metabolism, brain nerve cells activating agent, a brain hypofunction suppressing agent, a brain function improving agent, or an agent for preventing or ameliorating brain dysfunction comprising, as an active ingredient, one or more selected from the group consisting of hydrophobic solvent extracts of tien-cha, rooibos, grape and black tea.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: February 23, 2021
    Assignee: Kao Corporation
    Inventors: Keiko Ishida, Koichi Misawa, Kohjiro Hashizume
  • Patent number: 10925962
    Abstract: Provided are: a polymeric IgA-type recombinant antibody; a medicine containing this polymeric IgA-type recombinant antibody as an active ingredient; a method for producing this polymeric IgA type antibody, the method including the step of coexpressing an IgA-type antibody heavy-chain protein, an antibody light-chain protein, an antibody J-chain protein, and a secretory component protein within a single cell; and a method for improving the antigen-binding activity or neutralizing activity of this antibody, the method including the step of making an antibody into a polymeric IgA-type.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: February 23, 2021
    Assignee: Nippi, Incorporated
    Inventors: Shinji Saito, Tadaki Suzuki, Hideki Hasegawa, Akira Ainai, Kiyoko Goto, Tomonori Ueno, Yuki Taga
  • Patent number: 10919974
    Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: February 16, 2021
    Assignees: Ganymed Pharmaceuticals GmbH, Johannes Gutenberg-Universitat Mainz
    Inventors: Ugur Sahin, Ozlem Tureci, Michael Koslowski, Korden Walter, Stefan Woll, Maria Kreuzberg, Bernd Hubner, Michael Erdeljan, Michael Weichel
  • Patent number: 10921322
    Abstract: Provided are methods of detecting a marker for active tuberculosis, and a portable device for carrying out a method of detecting a marker for active tuberculosis. Also provided is a system for carrying out a method of detecting a marker for active tuberculosis, a method for pre-treating a sample stream from a human or animal suspected of having active tuberculosis, a system for pre-treating a sample stream from a human or animal suspected of having active tuberculosis and kits for performing said methods.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: February 16, 2021
    Assignees: KEI INTERNATIONAL LIMITED, TOMORROWS IP LIMITED
    Inventor: Johannes Theodorus Castrop
  • Patent number: 10889865
    Abstract: The invention relates to methods and kits for detecting thyroid cancer by detecting differences in the expression of genes that are differentially expressed in thyroid cancer cells.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: January 12, 2021
    Assignee: Cornell University
    Inventors: Thomas J. Fahey, III, Nimmi Kapoor, Theresa Scognamiglio
  • Patent number: 10836996
    Abstract: To provide a cell culture kit including cultured living cells of various donors, and a manufacturing method thereof. The cell culture kit includes a culture plate and living cells cultured thereon. The culture plate includes a plurality of microchambers (33) and living cells derived from various donors are adhered to surfaces of the plurality of microchambers (33). Specifically, living cells D1, D2, and D3 derived from various donors are adhered to the plurality of microchambers (33). In each microchamber (33), living cells derived from one donor or living cells derived from various donors may be cultured. The living cells derived from various donors are adhered and cultured in the cell culture kit as a whole, which makes it possible to provide a cell culture kit to conduct a test using cells derived from various donors.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: November 17, 2020
    Assignees: Corning Incorporated, Public University Corporation Yokohama City University
    Inventors: Yoko Itchoda, Go Tazaki, Motohiro Fukuda, Hitoshi Tsuruta, Hideki Taniguchi
  • Patent number: 10816549
    Abstract: A method of detecting epithelial cancer is described that includes the steps of: (a) determining the level of beta defensin 3 (BD-3) and beta defensin 2 (BD-2) in a suspect sample obtained from a subject; (b) comparing the level of BD-3 to BD-2 determined in the suspect sample to obtain a suspect BD-3/BD-2 ratio, (c) comparing the suspect BD-3/BD-2 ratio to a healthy BD-3/BD-2 ratio to obtain a diagnostic BD-3/BD-2 ratio; and (d) characterizing the subject as having epithelial cancer if the diagnostic BD-3/BD-2 ratio is greater than 1. A microfluidic device for detecting epithelial cancer using the diagnostic BD-3/BD-2 ratio is also described.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: October 27, 2020
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Aaron Weinberg, Santosh Ghosh, Umut A. Gurkan
  • Patent number: 10793518
    Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: October 6, 2020
    Assignee: Life Technologies Corporation
    Inventors: Wenjun Zhou, Kyle Gee, Yolanda Tennico, Peter Slade, Hee Chol Kang, Shaheer Khan, Brian Evans, James Stray
  • Patent number: 10780271
    Abstract: Technology for the transition of light and sound over long distances, e.g. TV and radio, has revolutionized society. On the contrary, the technology to perceive a smell remotely is in its infancy, and has severe limitations such as latency, residual and infidelity. A system and methods are disclosed to allow smells to be perceived remotely. It is based on the brain waves associated with the olfactory bulb.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: September 22, 2020
    Inventors: Lucas Mingzhi Zhou, Lin Zhou, Christopher Li
  • Patent number: 10768184
    Abstract: The present invention relates to a method of identifying a compound that binds to or modulates the activity of one or more polypeptides encoding one or more receptors that are involved in the detection and perception of fatty acids.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: September 8, 2020
    Assignee: MARS, INCORPORATED
    Inventors: Scott Joseph McGrane, Andrew John Taylor, Matthew Ronald Gibbs, Richard Masten Fine, Boris Klebansky
  • Patent number: 10745728
    Abstract: This invention relates to the use of analogs of purines that have two tautomeric forms, one formally complementary to thymidine, the other formally complementary to cytidine, and analogs of pyrimidines that have two tautomeric forms, one formally complementary to guanosine, the other formally complementary to adenosine. These uses include the polymerase chain reaction amplification of targets having polymorphisms in primer binding sites and ligation.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: August 18, 2020
    Inventors: Steven A Benner, Hyo-Joong Kim, Zunyi Yang
  • Patent number: 10736906
    Abstract: The present invention provides for compositions and methods for modulating tissue growth using tissue growth modulators, which are agents that either enhance or inhibit tissue growth as desired by a particular indication by modulating the PG or Wnt signaling pathways, or employing modulators of both PG and Wnt signaling pathways for a synergistic effect or highly selective effect.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: August 11, 2020
    Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, THE GENERAL HOSPITAL CORPORATION
    Inventors: Leonard I. Zon, Trista E. North, Wolfram Goessling
  • Patent number: 10739354
    Abstract: In one aspect, the invention relates to a method for identifying a compound which modulates the activity of a voltage-gated protein. In certain embodiments, the voltage gate protein is a voltage-gated ion channel. In certain embodiments, the voltage-gated protein is a voltage sensitive phosphatase. In certain embodiments, the voltage-gated protein used in conjunction with the methods of the invention is modified to altered permeability or voltage sensitivity.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: August 11, 2020
    Assignee: D.E. SHAW RESEARCH, LLC
    Inventors: Morten Østergaard Jensen, David Wayne Borhani, Vishwanath Jogini
  • Patent number: 10740655
    Abstract: A system and method automatically predicts an evolution of a cognitive score for a subject by classifying a cognitive data set for the subject into a first or second class by determining the cognitive set of data for each subject of a group, acquiring for each subject a neuropsychological score used for classifying each subject in the first or second class, and training a two-class machine learning classification algorithm on the cognitive data sets of all subjects. For each subject, the cognitive data set is used as input of the algorithm and the obtained classification of the subject as output target of the algorithm. The algorithm classifies each cognitive data set in the first or second class. The evolution of the cognitive score of a subject is predicted by the trained algorithm for automatically classifying a new cognitive dataset for the subject into the first or second class.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: August 11, 2020
    Assignees: Centre Hospitalier Universitaire Vaudois, Siemens Healthcare GmbH
    Inventors: Jonas Richiardi, Tobias Kober, Julius Popp
  • Patent number: 10724039
    Abstract: The present disclosure relates to a DNA aptamer which specifically binds to an insulin receptor, and a composition for treating diabetes and a composition for diagnosing diabetes which contain the same as an active ingredient, and the aptamer is characterized by being able to treat and diagnose diabetes more effectively than side effects caused by insulin such as increased incidence of cancer and atherosclerosis by having a different binding mechanism from existing insulin.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: July 28, 2020
    Assignees: Posco, Postech Academy-Industry Foundation
    Inventors: Sung Ho Ryu, Na-Oh Yunn, Jong Hun Im, Ara Koh, Eun Ju Oh, Sehoon Park, Jiyoun Lee, Sung Key Jang, Seungmin Han, Youndong Kim
  • Patent number: 10722509
    Abstract: Methods are provided herein for identifying whether a cancer patient, for example a colorectal cancer patient, will be responsive to treatment with a therapeutic strategy comprising administration of the FOLFOX regimen (5-fluorouracil, leucovorin, and oxaliplatin). Specified TYMP and UCK2 fragment peptides are precisely detected and quantitated by SRM-mass spectrometry directly in tumor cells, for example colorectal cancer tumor cells, that are collected from tumor tissue obtained from a cancer patient and compared to reference levels in order to determine if the cancer patients will positively respond to treatment with the combination treatment of FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin).
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: July 28, 2020
    Assignee: NantOmics, LLC
    Inventors: Fabiola Cecchi, Todd Hembrough
  • Patent number: 10705100
    Abstract: Methods for accurately comparing the levels of ionizable lipids in two cell populations that differ in some respect from each other using mass spectroscopy and isotopic labeling are provided. The methods can be used to identify a change in a lipid of interest in response to a cellular, chemical, genetic, or environmental change to the cell population (i.e., a lipid response to a cell perturbation). The change in the lipid of interest can be a change in composition, rate of synthesis, and/or location of the lipid.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: July 7, 2020
    Inventors: Scott B. Hansen, Andrew S. Hansen
  • Patent number: 10688127
    Abstract: Methods for use of structures based on graphene-related materials are disclosed. These structures can be utilized for manipulating the cell transmembrane potential in various biomedical applications.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: June 23, 2020
    Inventor: Elena Molokanova
  • Patent number: 10639371
    Abstract: The present invention provides a bioconjugate. The bioconjugate comprises a first molecule comprising an elastin-like peptide (ELP), a second molecule capable of self-associating into an oligomer, and a linker connecting the first molecule with the second molecule. The bioconjugate is self-assembled into particles, which are disassembled when the temperature is increased. Also provided is a method for delivering a bioconjugate to a target matrix, comprising (a) introducing a bioconjugate self-assembled into particles to a target matrix, wherein the bioconjugate comprises a first molecule comprising an elastin-like peptide (ELP), a second molecule capable of self-associating into an oligomer, and a linker connecting the first molecule with the second molecule, and (b) increasing the temperature of the target matrix to disassemble the particles at the target matrix.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: May 5, 2020
    Assignee: University of Delaware
    Inventors: Kristi Kiick, Tianzhi Luo
  • Patent number: 10632175
    Abstract: The present invention is related to methods and compositions effective in regulating glycemic control in subject individuals in need of the regulation of glycemic control. Said individuals may have diabetes or be prediabetic condition receive therapeutically effective amounts of identified secreted proteins in an amount suitable for modulating glycemic control and to thereby treat or prevent diabetes in said subject.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: April 28, 2020
    Assignee: Joslin Diabetes Center, Inc.
    Inventors: Laurie J. Goodyear, Kristin I. Stanford
  • Patent number: 10627408
    Abstract: Antibodies are used as biomarkers to assist in distinguishing gluten immune reactivity and sensitivity, silent celiac disease, Crohn's disease and other gut-related pathologies from classical celiac disease. In one class of embodiments, sera, saliva or other samples from a human or other animal are tested for antibodies to (a) a wheat antigen; (b) a gliadin antigen; and (c) one or more of a wheat germ agglutinin, a gluteomorphin, a glutenin, a deamidated glutenin, a prodynorphin, and a dynorphin. Test results are considered particularly interesting where the wheat antigen and the gliadin antigen are both selected from the group consisting of native and deamidated forms of ?-gliadin 33-mer, ?-gliadin-17-mer, ?-gliadin-15-mer, ?-gliadin-17-mer, and glutenin 21-mer.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: April 21, 2020
    Assignee: Cyrex Laboratories, LLC
    Inventor: Aristo Vojdani
  • Patent number: 10611834
    Abstract: The present invention provides a screening method for a pain suppressor, which method comprises using FLRT3 to select a substance capable of inhibiting FLRT3 expression or a substance capable of inhibiting FLRT3 transport to the spinal cord. In addition, the present invention provides a pharmaceutical composition for prevention or treatment of pain, which pharmaceutical composition comprises, as an active ingredient, a substance capable of inhibiting FLRT3 expression or a substance capable of inhibiting FLRT3 transport to the spinal cord.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: April 7, 2020
    Assignee: Osaka University
    Inventors: Toshihide Yamashita, Yasufumi Hayano, Moe Yamada
  • Patent number: 10613083
    Abstract: A biosensor system for the detection of target analytes that includes a living biological cell of a predetermined type; a signal-generating reporter associated with the living biological cell; a signal transduction pathway or other activator mechanism or means associated with the signal-generating reporter; a universal detector element associated with the activator mechanism; and an analyte binding element associated with the universal detector element, wherein the analyte binding element is specific to both the universal detector element and a target analyte.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: April 7, 2020
    Assignee: Fundamental Solutions Corporation
    Inventors: Thomas J. Zupancic, Joseph D. Kittle, Lingchun Zeng, Srikanth Vedamoorthy, Richard S. Brody, Marvin R. Williams
  • Patent number: 10597697
    Abstract: The invention discloses a method for determining a nucleotide sequence of a nucleic acid segment present in a biological sample, comprising the steps of: a) generating a fluorescent image of the sample by a protocol comprising immunofluorescence detection of at least five different target proteins in the sample; b) selecting a region of interest of the sample by comparing the image to a predetermined criterion; c) removing a subsample from the region of interest, and; d) determining a nucleotide sequence of a nucleic acid segment present in the subsample.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: March 24, 2020
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: John Richard Nelson, Qingyan Au, Wei Gao, Ryan Charles Heller, Nicholas Hoe, Nam Tran, Nichole Lea Wood
  • Patent number: 10591364
    Abstract: The present invention relates to the use of one or more amplicons as temperature calibrators. In some embodiments, the calibrators may be used to calibrate the temperature of a microfluidic channel in which amplification and/or melt analysis is performed. In some embodiments, the amplicons may be genomic, ultra conserved elements and/or synthetic. The amplicon(s) may have a known or expected melt temperature(s). The calibrators may be added to primers of study or may follow or lead the primers of study in the channel. The amplicon(s) may be amplified and melted, and the temperature(s) at which the amplicon(s) melted may be determined. The measured temperature(s) may be compared to the known temperature(s) at which the amplicon(s) was expected to melt. The difference(s) between the measured and expected temperatures may be used to calibrate/adjust one or more temperature control elements used to control and/or detect the temperature of the channel.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: March 17, 2020
    Assignee: Canon U.S.A., Inc.
    Inventors: Fernando DeCastro, Renee Howell, Sami Kanderian, Johnathan S. Coursey, Kenton C. Hasson, Scott Sundberg
  • Patent number: 10544472
    Abstract: A protein reporter system comprising at least one reporter including a response element responsive to the binding of a transcription factor, a secreted enzyme backbone and a recognition region for specific binding of an antibody. Multiplexed assays for binding, assaying and quantifying the activity of transcription factors are also described, in which the assays use protein reporters in sets, libraries or other groupings, as necessary to achieve desired quantification.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: January 28, 2020
    Assignee: ATTAGENE, INC.
    Inventors: Sergei S. Makarov, Ming Zheng
  • Patent number: 10543243
    Abstract: The invention relates to a soybean seed extract, method for producing the same and uses of the extract of soybean seeds in promoting wound healing, promoting neuron cell proliferation and/or treating brain diseases and/or neurodegenerative diseases, treating breast cancer, reducing side effects of interfering with DNA and/or RNA replication drugs and/or enhancing pharmaceutical effects of interfering with DNA and/or RNA replication drugs.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: January 28, 2020
    Assignee: CHARSIRE BIOTECHNOLOGY CORP.
    Inventor: Chu I-Hung
  • Patent number: 10539570
    Abstract: In various implementations, a noninvasive, food sensitivity test may be utilized to identify one or more food sensitivities. A fecal sample may be obtained. The food sensitivity test may be performed on the obtained fecal sample. One or more food sensitivities may be identified based on the food sensitivity test.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: January 21, 2020
    Inventor: Kenneth Davin Fine