Oxygen Atom Of The Saccharide Radical Is Directly Bonded To A Condensed Ring System Having Three Or More Carboxyclic Rings (e.g., Dauomycin, Adriamycin, Etc.) Patents (Class 435/78)
  • Patent number: 11396646
    Abstract: Polynucleotides encoding corresponding polypeptides capable of glycosylating steviol at its C-19 position to produce a steviol glycoside, an expression vector including such a polynucleotide, a method for producing a steviol glycoside by culturing a recombinant host cell containing such an expression vector under conditions in which the cell expresses the UDP-glycosyltransferase from the polynucleotide, and a method for producing a steviol glycoside by contacting a composition including steviol with a recombinant UDP-glycosyltransferase. The steviol glycoside can be steviol-19-O-glycoside. The recombinant host cell containing such an expression vector can be a bacterial cell, a plant cell, or a fungal cell, an animal cell, or a multicellular organism such as a plant.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: July 26, 2022
    Inventors: Xu Li, Han-Yi Chen, Nickolas Anderson, Amanda Waters
  • Patent number: 11352653
    Abstract: Provided is a method for preparing rebaudioside N using an enzymatic method, comprising using rebaudioside A or rebaudioside J as a substrate, and making the substrate, in the presence of a glycosyl donor, react under the catalysis of a UDP-glycosyl-transferase and/or a UDP-glycosyltransferase-containing recombinant cell to generate rebaudioside N.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: June 7, 2022
    Assignee: PEPSICO, INC.
    Inventors: Alex Tao, Guoqing Li, Wenxia Wang, Leilei Zheng, Chunlei Zhu, Xiaoliang Liang, Kuikiu Chan
  • Patent number: 11312985
    Abstract: Provided is a method for preparing Rebaudioside C using an enzymatic method, comprising using rubusoside or dulcoside A as a substrate, and making the substrate, in the presence of a glycosyl donor, react under the catalysis of UDP-glycosyltransferase-containing recombinant cell and/or UDP-glycosyltransferase prepared therefrom to generate Rebaudioside C.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: April 26, 2022
    Assignee: PepsiCo, Inc.
    Inventors: Alex Tao, Guoqing Li, Wenxia Wang, Leilei Zheng, Chunlei Zhu, Xiaoliang Liang, Kuikiu Chan
  • Patent number: 11248248
    Abstract: The invention relates to recombinant microorganisms and methods for producing mogroside compounds and mogroside precursors.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: February 15, 2022
    Assignee: EVOLVA SA
    Inventor: Jens Houghton-Larsen
  • Patent number: 11230724
    Abstract: In various aspects and embodiments, the invention provides microbial cells and methods for producing advanced glycosylation products from lower glycosylated intermediates. The microbial cell expresses one or more UDP-dependent glycosyl transferase enzymes in the cytoplasm, for glycosylation of the intermediates. When incubating the microbial strain with a plant extract or fraction thereof comprising the intermediates, these glycosylated intermediates are available for further glycosylation by the cell, and the advanced glycosylation products can be recovered from the media and/or microbial cells.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: January 25, 2022
    Assignee: MANUS BIO INC.
    Inventors: Ajikumar Parayil Kumaran, Christine Nicole S. Santos, Jason Eric Donald, Mary Elizabeth Fowler, Ryan N. Philippe, Christopher Scott Frei, Aaron Love
  • Patent number: 10844414
    Abstract: Disclosed are methods for producing steviol glycosides, such as rebaudioside D and rebaudioside M, using engineered yeast. The methods include growing yeast on non-fermentative carbon sources. Other methods include growing yeast on one or more polysaccharides in which saccharification and fermentation of the polysaccharides occurs simultaneously.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: November 24, 2020
    Assignee: Cargill, Incorporated
    Inventors: James C. Anderson, Ting Liu Carlson, Arlene M. Fosmer
  • Patent number: 10703773
    Abstract: The present invention aims to provide a novel glycosyl hesperetin, which is significantly reduced in miscellaneous tastes characteristic of conventional products containing glycosyl hesperetin, and a method for producing the same and uses thereof; and the objects are solved by providing a glycosyl hesperetin which comprises glycosyl hesperetin in an amount of 90% or more by mass but less than 100% by mass, on a dry solid basis, but it does not substantially contain furfural, and a method for producing the same and uses thereof.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: July 7, 2020
    Assignee: HAYASHIBARA CO. LTD.
    Inventors: Mitsuyuki Kambe, Koichi Nishi, Akira Kawashima, Akiko Yasuda, Hitoshi Mitsuzumi, Toshio Ariyasu
  • Patent number: 10675259
    Abstract: A drug combination with antitumor effects, contains styrene acid derivatives and antitumor medicaments with same or different specifications of unit preparations that can be simultaneously or separately administrated, as well as pharmaceutically acceptable carriers. The joint use of trans-styrene acid derivatives and antitumor drugs provides synergistic action, and the use of trans-styrene acid derivatives combined with a part of antitumor drugs can further exert the toxicity attenuation effects, showing a good clinical application prospect.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: June 9, 2020
    Assignee: DONGGUAN ANHAO PHARMACEUTICAL CO., LTD.
    Inventor: Zhiquan Yong
  • Patent number: 10604743
    Abstract: The present invention relates to a recombinant host comprising a recombinant nucleic acid sequence encoding a polypeptide having at least about: a. 85% identity to the amino acid sequence set forth in SEQ ID NO: 1; b. 85% identity to the amino acid sequence set forth in SEQ ID NO: 3; c. 85% identity to the amino acid sequence set forth in SEQ ID NO: 6; d. 85% identity to the amino acid sequence set forth in SEQ ID NO: 9; e. 85% identity to the amino acid sequence set forth in SEQ ID NO: 11; f. 85% identity to the amino acid sequence set forth in SEQ ID NO: 14; g. 85% identity to the amino acid sequence set forth in SEQ ID NO: 17; h. 85% identity to the amino acid sequence set forth in SEQ ID NO: 20; i. 85% identity to the amino acid sequence set forth in SEQ ID NO: 22; or j. 85% identity to the amino acid sequence set forth in SEQ ID NO: 25.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: March 31, 2020
    Assignee: DSM IP ASSETS B.V.
    Inventors: Viktor Marius Boer, Johannes Gustaaf Ernst Van Leeuwen, Priscilla Zwartjens, Catharina Petronella Antonia Maria Kolen
  • Patent number: 10364450
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosylated ent-kaurenol, and glycosylated ent-kaurenoic acid.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: July 30, 2019
    Assignee: EVOLVA SA
    Inventors: Kim Olsson, Ernesto Simon, Michael Dalgaard Mikkelsen, Simon Carlsen, Veronique Douchin, Swee Chuang Lim, Louis During
  • Patent number: 10253344
    Abstract: Recombinant polypeptides having UDP-glycosyltransferase activities, including a 1,2-19-O-glucose glycosylation activity and a 1,2-13-O-glucose glycosylation activity for synthesizing of steviol glucosides, are provided. A method of producing a steviol glycoside composition using such recombinant polypeptide is also provided. Also disclosed are steviol glycosides referred to as rebaudioside Z1 and rebaudioside Z2.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: April 9, 2019
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Patent number: 10059732
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: August 28, 2018
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Patent number: 10010099
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: July 3, 2018
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Patent number: 10010101
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: July 3, 2018
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Patent number: 9850270
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: December 26, 2017
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Patent number: 9670242
    Abstract: Disclosed are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, W, n are defined as in the present application. Also disclosed is a method for treating cancer, comprising administering to a subject in need thereof a therapeutically effective amount of the compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The compound and a salt thereof according to the present application possess good anticancer and/or antitumor activity, and good water solubility and stability, as well as good tolerance in animal bodies. Also disclosed is a process for preparing a compound represented by formula (I) of the present application, comprising reacting a compound represented by formula (II) with a compound represented by formula (III) in the presence of a condensation agent to obtain a compound represented by formula (I).
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: June 6, 2017
    Assignee: Tianjin Hemay Oncology Pharmaceutical Co., Ltd.
    Inventors: Hesheng Zhang, Aihong Huo, Zhenzhong Li
  • Patent number: 9643990
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: May 9, 2017
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Patent number: 9603373
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavors, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: March 28, 2017
    Assignee: PureCircle Sdn Bhd
    Inventor: Avetik Markosyan
  • Patent number: 9567619
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebaudioside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: February 14, 2017
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Patent number: 9392799
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: July 19, 2016
    Assignee: PureCircle Sdn Bhd
    Inventor: Avetik Markosyan
  • Patent number: 9386797
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: July 12, 2016
    Assignee: PureCircle Sdn Bhd
    Inventor: Avetik Markosyan
  • Publication number: 20150128306
    Abstract: The invention provides a method for producing steviol glycosides. The invention provides a transformant having introduced therein the steviol glucosyltransferase and a method for producing steviol glycosides using the transformant.
    Type: Application
    Filed: March 14, 2013
    Publication date: May 7, 2015
    Applicant: SUNTORY HOLDINGS LIMITED
    Inventor: Eiichiro Ono
  • Patent number: 8993269
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: March 31, 2015
    Assignee: PureCircle USA Inc.
    Inventor: Avetik Markosyan
  • Publication number: 20150031869
    Abstract: Methods of preparing highly purified steviol glycosides, particularly rebaudiosides A, D and X are described. The method includes expression of UDP-glucosyltransferases from Stevia rebaudiana Bertoni, which are capable converting certain steviol glycosides to rebaudiosides A, D and X. The highly purified rebaudiosides A, D and X, are useful as non-caloric sweetener in edible and chewable compositions such as any beverages, confectioneries, bakery products, cookies, and chewing gums.
    Type: Application
    Filed: August 26, 2014
    Publication date: January 29, 2015
    Inventors: Avetik MARKOSYAN, Cyrille JARRIN, Patrick ROBE, Rob ter HALLE, Indra PRAKASH, Venkata Sai PRAKASH CHATURVEDULA
  • Publication number: 20150031868
    Abstract: The present invention relates to a recombinant microorganism comprising one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity, whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol. The recombinant microorganism may also be capable of expressing one or more UDP-glucosyltransferases such that the microorganism is capable of producing one or more steviol glycosides.
    Type: Application
    Filed: January 23, 2013
    Publication date: January 29, 2015
    Inventors: Martin Lehmann, Joshua Trueheart, Priscilla Zwart Jens, Liang Wu, Viktor Marius Boer, Cornelis Maria Jacobus Sagt, Manoj Kumar, Bernard Meijrink, Marco Alexander Van Den Berg
  • Publication number: 20150011660
    Abstract: The invention provides a process of producing Rubusoside from steviol glycosides of Stevia rebaudiana plant. The process is useful for producing high purity Rubusoside with purity greater than 95% (dry basis). High purity rubusoside is useful as in combination with other caloric and non-caloric sweeteners as well as non-caloric sweetener in various food and beverage compositions. The high purity rubusoside is useful as non-caloric sweetener in edible and chewable compositions such as any beverages, confectionaries, bakeries, cookies, chewing gums, and alike.
    Type: Application
    Filed: March 7, 2013
    Publication date: January 8, 2015
    Inventor: Avetik MARKOSYAN
  • Patent number: 8911971
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using starch as the source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: December 16, 2014
    Assignee: PureCircle USA Inc.
    Inventor: Avetik Markosyan
  • Publication number: 20140329281
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: August 8, 2012
    Publication date: November 6, 2014
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen Halkjaer, Ernesto Simon, Sabina de Andrade Periera Tavares
  • Patent number: 8877463
    Abstract: The present invention relates to Rhodanobacter ginsenosidimutans KCTC22231T-derived ginsenoside glycosidase and use thereof. The polypeptide has an activity of converting PPD (protopanaxadiol)-type saponins into in vivo absorbable and highly active deglycosylated saponins, by selective hydrolysis of a bond at a particular position of ginsenoside. The present invention also relates an amino acid sequence constituting the polypeptide, a nucleic acid sequence encoding the protein, a recombinant vector comprising the nucleic acid sequence, and a transformant transformed with the vector. The invention further provides a method for preparing Rhodanobacter ginsenosidimutans KCTC22231T-derived ginsenoside glycosidase by culturing the transformant, a method for converting PPD (protopanaxadiol)-type major ginsenoside into a rare ginsenoside that is absorbable in vivo using the protein, and a composition for converting PPD-type saponins into in vivo absorbable saponins, having the protein as an active ingredient.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: November 4, 2014
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Dong-Shan An, Song-Gun Kim, Sung-Taik Lee, Wan-Taek Im, Chang-Hao Cui
  • Patent number: 8795986
    Abstract: The invention relates to a method for the Bio-transformation of Thiocolchicine a colchicinoid compound into its glycosylated form using a selective microorganism Providencia vermicola. Use of bacterial strain, Providencia vermicola for microbial bio-transformation of thiocolchicine (TCN) to their corresponding 3-0-glycosyl derivative as well as specific strains of that species Providencia vermicola for microbial transformation of other colchicinoid compounds such as colchicine, thiocolchicine, 3-demethylcolchicine, 3-demethylthiocolchicine and N-deacetylthiocolchicine to its corresponding glycosylated form and subsequent isolation of the transformed compounds from the bacterial culture medium is disclosed. Providencia vermicola (MTCC 5578) a gram negative bacteria has been identified having trans-glycosylation ability and convert thiocolchicine (TCN) to Thiocolchicocide (TCS).
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: August 5, 2014
    Assignee: Sequent Scientific Ltd.
    Inventors: Krishnamurthy Prabakaran, Sankarasubramanian Kanagavelrajan, Nallasamy Mohanasundaram Kannamapuram, Ayyappan Hariharan Kooakarakkaran, Bhimaraju Poliseti
  • Patent number: 8772253
    Abstract: Aureolic acid derivatives, process for obtaining them and uses thereof. This invention provides a bacterial strain that produces compound belonging to the family of aureolic acids useful in the treatment of cancer or nervous system diseases.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: July 8, 2014
    Assignee: Entrechem, S.L.
    Inventors: Luz Elena Núñez González, Nuria Menéndez Sánchez, Javier González Sabin, Francisco Moris Varas, Beatriz García Fernández, Maria Pérez Solares, Alfredo Fernández Braña, Maria del Carmen Méndez Fernández, José Antonio Salas Fernández
  • Patent number: 8735101
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: May 27, 2014
    Assignee: PureCircle USA Inc.
    Inventor: Avetik Markosyan
  • Patent number: 8669077
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: March 11, 2014
    Assignee: PureCircle USA Inc.
    Inventor: Avetik Markosyan
  • Patent number: 8647844
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: February 11, 2014
    Assignee: PureCircle USA Inc.
    Inventor: Avetik Markosyan
  • Publication number: 20140024080
    Abstract: The invention relates to a method for the Bio-transformation of Thiocolchicine a colchicinoid compound into its glycosylated form using a selective microorganism Providencia vermicola. Use of bacterial strain, Providencia vermicola for microbial bio-transformation of thiocolchicine (TCN) to their corresponding 3-0-glycosyl derivative as well as specific strains of that species Providencia vermicola for microbial transformation of other colchicinoid compounds such as colchicine, thiocolchicine, 3-demethylcolchicine, 3-demethylthiocolchicine and N-deacetylthiocolchicine to its corresponding glycosylated form and subsequent isolation of the transformed compounds from the bacterial culture medium is disclosed. Providencia vermicola (MTCC 5578) a gram negative bacteria has been identified having trans-glycosylation ability and convert thiocolchicine (TCN) to Thiocolchicocide (TCS).
    Type: Application
    Filed: September 22, 2011
    Publication date: January 23, 2014
    Applicant: ELYSIAN LIFE SCIENCES PRIVATE LIMITED
    Inventors: Krishnamurthy Prabakaran, Sankarasubramanian Kanagavelrajan, Nallasamy Mohanasundaram Kannamapuram, Ayyappan Hariharan Dakarakkaran, Bhimaraju Poliseti
  • Patent number: 8603787
    Abstract: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: December 10, 2013
    Assignee: Xyleco, Inc.
    Inventor: Marshall Medoff
  • Publication number: 20130316043
    Abstract: A taste and flavor profile modifying composition is described. The composition includes glucosylated steviol glycosides which can modify the intensity of a taste and/or a flavor in a food or beverage product.
    Type: Application
    Filed: March 15, 2013
    Publication date: November 28, 2013
    Inventor: Siddhartha PURKAYASTHA
  • Publication number: 20130236537
    Abstract: The present invention provides a pharmaceutical preparation for tumor chemotherapy and a method for producing the same, the pharmaceutical preparation for tumor chemotherapy comprises cell vesicles derived from apoptotic tumor cells and chemotherapeutic drugs as active ingredients wrapped within the cell vesicles. The chemotherapeutic drugs contained within the pharmaceutical preparation are chemotherapeutic drugs containing active ingredients for the treatment of the tumors from which the cell vesicles are provided. The present invention also provides a method for producing the pharmaceutical preparation for tumor chemotherapy. The technical solutions provided by the present invention can selectively release the chemotherapeutic drugs to the tumor sites and maintain lasting medicinal effect, increasing their killing effects against tumor cells and reducing the toxic side-effect of the chemotherapeutic drugs to normal cells.
    Type: Application
    Filed: April 5, 2013
    Publication date: September 12, 2013
    Applicants: HUBEI SOUNDNY BIOTECHNOLOGY CO., LTD.
    Inventor: Bo Huang
  • Publication number: 20130171328
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: June 2, 2011
    Publication date: July 4, 2013
    Inventors: Ganesh M. Kishore, Michael Motion, Paula M. Hicks, Jorgen Hansen, Jens Houghton-Larsen, Esben Halkjær Hansen, Michael Dalgaard Mikkelsen, Sabina Tavares, Charlotte Blom
  • Patent number: 8426169
    Abstract: The present invention provides compounds characterized by the formula (I), where each of the substituent radicals is described in the specification. The invention also describes the use of said compounds in the treatment of various diseases, including: cancer or tumoral processes in general, Paget's disease, hypercalcaemia, hypercalciuria and neurological diseases (inter alia, Parkinson's, Alzheimer's, Huntington's).
    Type: Grant
    Filed: February 4, 2008
    Date of Patent: April 23, 2013
    Assignees: University of Kentucky Research Foundation, Universidad de Oviedo
    Inventors: Jürgen Rohr, Irfan Baig, José Antonio Salas Fernández, Alfredo Fernández Braña, Carmen Méndez Fernández, Mariá Pérez Solares
  • Publication number: 20120315672
    Abstract: The invention relates to recombinant expression of terpenoid synthase enzymes and geranylgeranyl diphosphate synthase (GGPPS) enzymes in cells and the production of diterpenoids.
    Type: Application
    Filed: November 10, 2010
    Publication date: December 13, 2012
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Effendi Leonard, Parayil K. Ajikumar, Kristala Lanett Jones Prather, Gregory Stephanopoulos, Kelly Thayer
  • Patent number: 8318459
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95 % content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: November 27, 2012
    Assignee: PureCircle USA
    Inventor: Avetik Markosyan
  • Publication number: 20120270823
    Abstract: Aureolic acid derivatives, process for obtaining them and uses thereof. This invention provides a bacterial strain that produces compound belonging to the family of aureolic acids useful in the treatment of cancer or nervous system diseases.
    Type: Application
    Filed: July 14, 2010
    Publication date: October 25, 2012
    Applicant: ENTRECHEM, S.L.
    Inventors: Luz Elena Núñez Gonzáez, Beatriz García Fernández, María Pérez Solares, Alfredo Fernández Braña, Nuria Menéndez Sánchez, Javier González Sabin, Francisco Morís Varas, María del Carmen Méndez Fernández, José Antonio Salas Fernández
  • Patent number: 8257948
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: September 4, 2012
    Assignee: PureCircle USA
    Inventor: Avetik Markosyan
  • Publication number: 20120190635
    Abstract: The present invention provides regio- and stereoselective oxidation of unactivated C—H bonds using an engineered mutant cytochrome P450 monooxygenase and an engineered substrate.
    Type: Application
    Filed: September 27, 2010
    Publication date: July 26, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shengying Li, David H. Sherman, John Montgomery, Mani R. Chaulagain, Allison R. Knauff
  • Publication number: 20120164678
    Abstract: The invention relates to recombinant expression of a steviol or steviol glycosides biosynthetic pathway enzymes in cells and the production of steviol or steviol glycosides.
    Type: Application
    Filed: November 29, 2011
    Publication date: June 28, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Parayil K. Ajikumar
  • Patent number: 8129196
    Abstract: The present inventions provides an apparatus and method for the parallel loading of multiple samples in a microarray containing a plurality of sub-arrays. The method makes use of a microarray containing multiple sub-arrays, a loading channel array, and a fluid handling robot or an assembly robot or machine.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: March 6, 2012
    Assignee: Roche Nimblegen, Inc.
    Inventors: Roland D Green, Mark McCormick, Gary Barrett
  • Publication number: 20110256588
    Abstract: The present invention relates to a method of producing Rebaudioside A in a high yield by recycling by-products produced when Rebaudioside A is produced from leaves of Stevia Rebaudiana Bertoni containing a sweetening material.
    Type: Application
    Filed: April 18, 2011
    Publication date: October 20, 2011
    Applicant: CJ CHEILJEDANG CORPORATION
    Inventors: Young Mi Lee, Seong Bo Kim, Young Ho Hong, Joo Hang Lee, Seung Won Park
  • Publication number: 20110218161
    Abstract: This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-?-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-?-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.
    Type: Application
    Filed: September 8, 2008
    Publication date: September 8, 2011
    Applicant: Tianjin Institute of Pharmaceutical Research
    Inventors: Yingmei Han, Guangping Xia, Weiren Xu, Zhuanyou Zhao, Wulin Liu, Naxia Zhao, Peng Liu, Shijun Zhang, Xiaoli Fu, Yuli Wang, Weiting Wang, Lida Tang
  • Publication number: 20110171691
    Abstract: A microbial strain which converts anthracycline metabolites into non-natural anthracycline antibiotics is described. A process for converting anthracycline metabolites into anthracycline antibiotics using a microbial strain is also described.
    Type: Application
    Filed: September 11, 2008
    Publication date: July 14, 2011
    Applicant: W.C. HERAEUS GMBH
    Inventors: Michael Lambert, Kristiina Ylihonko, Maria Holmback