Process Or Composition For Sterility Or Package Integrity Test Patents (Class 436/1)
  • Patent number: 10145800
    Abstract: In a method for detecting corrosion of a surface not exposed to view of a metal piece, radiant thermal energy is directed against the piece by pulsed laser beam illumination thereby causing heating of said piece. Infrared radiation emitted by the piece is detected by a thermographic camera so that corroded portions of said surface are detected due to a different thermal response as a function of time relative to non-corroded portions. The laser beam is directed against an exposed face of a wall of said piece whose opposite face is the surface on which corrosion must be detected. The thermographic camera is provided on a same side where a laser head for emitting said laser beam is provided and has a control system for performing “Lock-in” thermography. Detection of the surface corroded portions is carried out by comparing a response of different surface portions during cooling of the piece.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: December 4, 2018
    Assignee: C.R.F. Società Consortile per Azioni
    Inventors: Marie Marguerite Dugand, Claudio Errigo
  • Patent number: 9951370
    Abstract: A chemical indicating composition. The composition can include an aqueous resin in a form of polymer emulsion or polymer dispersion, the aqueous resin comprising a first aqueous resin composition and a second aqueous resin composition; a film-forming agent; a color changing composition; and water as a solvent. The chemical indicating composition of this disclosure can be used in an autoclave process indicator.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: April 24, 2018
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Liwei Yu, Kai Qiu
  • Patent number: 9851346
    Abstract: The present document describes a screening composition comprising a marker compound, chosen from at least one of iodine, and fluorescein; eosin Y, erythrosine, ponceau S, calcein, a catalyst, chosen from at least one boron trioxide (B2O3), potassium (K), Gallium (III) oxide (Ga2O3), Nickel (II) oxide (NiO), Vanadium (V) oxide (V2O5), magnesium oxide (MgO), a bismuth oxide chosen from bismuth subcarbonate [Bi2O2(CO3)], bismuth chloride oxide (BiClO), and bismuth oxide (Bi2O3), cesium bromide (CsBr), lanthanum (III) oxide (La2O3), molybdenum (VI) oxide (MoO3), neodymium oxide (Nd2O3), Nickel (II) carbonate anhydrous (NiCO3); and a pigment, chosen from at least one of scandium (III) oxide (Sc2O3), Lead (IV) oxide (PbO2), Sulfur (S) powder, and Tungsten (VI) oxide (WO3), chromium (III) oxide (Cr2O3), copper (II) oxide (CuO), copper (I) oxide (Cu2O), iron (III) oxide (Fe2O3), lead (II) oxide (PbO). The document also describes method of using the same.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: December 26, 2017
    Assignee: Bryson Patents Inc.
    Inventor: Bryan Christopher Farnum
  • Patent number: 9752902
    Abstract: A disposable ophthalmic or medical apparatus has a portion with a color changeable dye disposed thereon. The dye changes color after being exposed to oxygen for a controlled and predetermined period of time indicating that the apparatus should no longer be used.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: September 5, 2017
    Assignee: Sensor International LLC
    Inventors: Gregory Lee Heacock, Louise Ellen Culham
  • Patent number: 9244016
    Abstract: An indicator for detecting peroxide can detect the peroxide through change of hue thereof by reacting the peroxide according to a predefined concentration and a predefined sterilization treatment condition thereof. The indicator has better resistance against weather or light and preservation stability than those of prior indicators including inorganic compounds or organic compounds as discoloration components, can clearly change an arbitrary hue thereof under suitable discoloration rate, and has visible distinguishability. The indicator for detecting peroxide includes powdery metal sulfide, that undergoes discoloration by reacting with the peroxide. In particular a discoloration layer including the metal sulfide is applied onto at least a portion of a base substrate.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: January 26, 2016
    Assignee: NiGK CORPORATION
    Inventors: Ryo Karato, Nobuyuki Ando
  • Patent number: 9188536
    Abstract: A self-contained, remotely interrogatable, autonomously positionable, pressure probe and methods of manufacturing and using. The probe (10) includes (i) a hermetically sealed, flexible, gas impermeable sachet (50) capable of equilibriating to a surrounding pressure, (ii) an optically-active, target-analyte partial pressure sensitive material (20) within the sachet, and (iii) a gaseous headspace (58) within the sachet containing a known concentration of the target-analyte (A).
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: November 17, 2015
    Assignee: LUXCEL BIOSCIENCES, LTD
    Inventors: Dmitri Boris Papkovsky, Richard Fernandes
  • Patent number: 9139348
    Abstract: A pouch includes: a first closed, inner casing, made of at least one non-porous plastic material with a high-capacity gas barrier, delimiting a first space, forming a pouch stricto sensu for accommodating a biopharmaceutical product or device, a second closed, outer casing, made of at least one non-porous plastic material with a high-capacity gas barrier, delimiting a second space in which the pouch stricto sensu is located, spacer elements, at least one selected tracer gas, located in the first or second space outside of the pouch stricto sensu, with a higher partial pressure than in the second space outside of the pouch stricto sensu or in the first space, at least one colorimetric detector located, respectively, in the second space outside of the pouch stricto sensu or in the first space responsive to the concentration of the tracer gas, by switching from a first color to a second different color.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: September 22, 2015
    Assignee: SARTORIUS STEDIM FMT SAS
    Inventor: Nicolas Voute
  • Patent number: 9132949
    Abstract: The invention pertains to a method of connecting at least two containers for enabling a transfer of liquid from one container to the other container, comprising the steps of: a) Depositing a first cassette including at least a first container on a first tray. The first container has a plurality of connecting means. b) Depositing a second cassette including a second container on a second tray. The cassettes or the containers include a data storage means. c) The data are read by respective data reading means. d) The data are processed and it is verified whether they match each other. e1) In case of a negative result, the second cassette is removed and the steps from step b) onwards are repeated. e2) In case of a positive verification result, the containers are connected. f) Removing the second cassette. g) Repeating steps b) to f) a plurality of times.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: September 15, 2015
    Assignee: Terumo BCT, Inc.
    Inventors: Francois Bidet, Roland Biset, Wilfried Mertens
  • Patent number: 9005978
    Abstract: A pouch (2) includes: a first, inner, envelope (1) which is closed, delimiting a first space (6) forming a pouch stricto sensu (1) intended for receiving a biopharmaceutical product or device; a second, outer, envelope (8) which is closed, delimiting a second space (9) in which is located the first envelope/pouch stricto sensu (1); a spacer element (11); at least one tracer gas located in the first space (6) or in the intermediate space (14) at a partial pressure different from that of the intermediate space or of the first space; and at least one colorimetric detection layer (12), responding to the concentration of tracer gas which reaches it by changing from a first color to a second color, and being an integral part of a wall (3, 4) of the first envelope/defined pouch (1) and/or of a wall (13) of the second envelope and/or of the spacer element.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: April 14, 2015
    Assignee: Sartorius Stedim FMT SAS
    Inventors: Lars Bottcher, Martin Dahlberg
  • Publication number: 20150050196
    Abstract: A colorimetric time indicator configured to indicate time specificity is provided. The colorimetric time indicator includes a colorimetric layer configured to be operatively coupled to a disposable medical device. The colorimetric time indicator is configured to indicate the time specificity via one or more visual indicators upon exposure to one or more external stimuli.
    Type: Application
    Filed: August 14, 2013
    Publication date: February 19, 2015
    Applicant: General Electric Company
    Inventors: Kwok Pong Chan, Sumeet Jain, Matthew Jeremiah Misner, Pekka Simeon Astola, Johannes Harri Eemeli Osterberg
  • Publication number: 20150024501
    Abstract: A chemical indicator device for use in detecting exposure to an oxidizing agent, such as hydrogen peroxide, comprising a substrate or support upon which is disposed a chemical indicator composition (ink) for detecting an oxidizing agent, such as hydrogen peroxide. The chemical indicator composition further comprises an indicator dye that achieves a distinct range of different color changes with clear transitions between colors, upon exposure to different doses of the oxidizing agent, thus allowing for both a qualitative and semi-quantitative assessment of exposure to the agent.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 22, 2015
    Inventors: Stephen Michael LACY, Neil David TYERS
  • Publication number: 20150004706
    Abstract: An indicator composition can be used to detect various environmental conditions stimuli such as in sterilization or storage processes. This indicator composition has a) a first polymeric particle comprising a solid continuous polymeric phase and a first reactant, the first polymeric particle having a mode particle size equal to or less than 50 ?m; and b) a second reactant outside of the first polymeric particle, which second reactant is capable of reacting with the first reactant when exposed to a chosen environmental condition stimulus. The indicator composition can be used by exposing it to the environmental condition stimulus for a sufficient time to cause a detectable change in the indicator composition such as a detectable color change.
    Type: Application
    Filed: June 26, 2013
    Publication date: January 1, 2015
    Inventors: Mridula Nair, Kevin D. Lofftus, Mary Christine Brick
  • Publication number: 20150004707
    Abstract: An indicator composition can be exposed to various environmental conditions stimuli such as in sterilization or storage processes. This indicator composition has a) a first polymeric particle comprising a solid continuous polymeric phase and a first reactant, the first polymeric particle having a mode particle size equal to or less than 50 ?m; and b) a second reactant outside of the first polymeric particle, which second reactant is capable of reacting with the first reactant when exposed to a chosen environmental condition stimulus. The indicator composition can be used by exposing it to the environmental condition stimulus for a sufficient time to cause a detectable change in the indicator composition such as a detectable color change.
    Type: Application
    Filed: June 26, 2013
    Publication date: January 1, 2015
    Inventors: Mridula Nair, Kevin D. Lofftus, Mary Christine Brick
  • Publication number: 20140370604
    Abstract: Water-based formulations comprising an indicating composition dispersed in water are described. The water-based indicating compositions include an organic Bi(III) compound, a sulfur source, and a carbonate salt. Formulations further including a resin and/or an acidic additive are also described.
    Type: Application
    Filed: December 18, 2012
    Publication date: December 18, 2014
    Inventors: Kevin D. Landgrebe, Ranjani V. Parthasarathy, Anthony E. Bennett, Peter T. Elliott, Steven S. Kirckof
  • Publication number: 20140356963
    Abstract: There is provided a sterilization indicating tape having a breathable and liquid impervious film, wherein the tape is printed with a sterilization indicator ink. The tape is compatible with a wrap polymer for recycling. The tape is used to hold a wrapped package closed so that it can be sterilized and stored. The ink changes color upon sterilization to show the user that the package has been subject to sterilization. The tape is desirably made from the same or a similar polymer to the wrap polymer so that they may be recycled together.
    Type: Application
    Filed: May 15, 2014
    Publication date: December 4, 2014
    Applicant: Kimberly-Clark Worldwide, Inc.
    Inventor: Laura E. Keck
  • Publication number: 20140322072
    Abstract: Techniques for sterilizing chlorhexidine based antiseptic formulations include exposing a sealed container containing the formulation to heat at a temperature and heating time sufficient to sterilize the chlorhexidine based antiseptic formulation and the hermetically sealed interior of the container, which may be an applicator, a bottle, a swab stick, or a pad-containing pouch.
    Type: Application
    Filed: August 8, 2013
    Publication date: October 30, 2014
    Applicant: LERNAPHARM (LORIS) INC.
    Inventors: Razmik MARGOOSIAN, Viken AFARIAN
  • Patent number: 8859222
    Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: October 14, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Leo Martis, Mehul Patel, Joseph A. Giertych, James W. Mongoven, Jacqueline A. Kunzier, William F. Owen
  • Publication number: 20140273239
    Abstract: An air removal test system for verifying adequate air removal during a sterilization cycle of a pre-vacuum type sterilizer includes specimen holder and a test strip. The test strip includes a solid indicator chemical, which liquefies and travels along a wicking element during the sterilization cycle. The test strip is configured to verify adequate removal of air during the sterilization cycle by displaying a color change through a window.
    Type: Application
    Filed: May 30, 2014
    Publication date: September 18, 2014
    Applicant: Dana Products, Inc.
    Inventor: Harry Bala
  • Publication number: 20140271345
    Abstract: A sterilization indicator apparatus is provided. The sterilization indicator apparatus includes a base member having a top side and a bottom side. In a preferred embodiment, the base member is constructed of a plastic material such as a polypropylene. An adhesive is applied to the bottom side of the base member. In one embodiment, a latex-free resin is employed, but other types of adhesives may also be employed. One or more indicator elements are located on the surface opposite the adhesive. The indicator elements may take any shape, such as bars, squares, circles, ellipses, or any desired shape. The indicator elements function as sterilization indicators that are capable of indicating whether or not they have been exposed to a sterilization process.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Inventors: Michael Pavesi, Daniel Swiger
  • Publication number: 20140199768
    Abstract: A device indicates the location of an air leak in a vacuum bag used to process composite parts. The device includes a layer of material on the inner face of the bag that changes in appearance due to an oxidation-reduction reaction in areas of the layer exposed to oxygen caused by a leak in the bag.
    Type: Application
    Filed: March 18, 2014
    Publication date: July 17, 2014
    Applicant: The Boeing Company
    Inventors: John N. Harris, Finley Miller, Michael R. Swift
  • Patent number: 8758690
    Abstract: A sterilization indicator having a compound that is of the heating type when put into contact with atoms of oxygen O and/or nitrogen N; and a thermochromic dye, in thermal contact with the compound.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: June 24, 2014
    Assignee: Societe pour la Conception des Applications des Techniques Electroniques
    Inventors: André Ricard, Francis Dieras, Michel Sixou, Sandrine Villeger, Cristina Canal, Pilar Erra
  • Publication number: 20140154808
    Abstract: Compositions, devices and processes related to etching of a very thin layer or fine particles of a metal are disclosed for monitoring a variety of parameters, such as time, temperature, time-temperature, thawing, freezing, microwave, humidity, ionizing radiation, sterilization and chemicals. These devices have capabilities of producing a long and sharp induction period of an irreversible visual change. The devices are composed of an indicator comprising a very thin layer of a metal and an activator, e.g., a reactant, such as water, water vapor, an acid, a base, oxidizing agent or their precursors, which is capable of reacting with the said indicator. Ink formulations composed of a metal powder and a proper activator can be used for monitoring several sterilization processes, such as sterilization with steam. When water is used as an activator, a thin layer of metals, such as that of aluminum can be used as steam sterilization or humidity indicator.
    Type: Application
    Filed: December 3, 2012
    Publication date: June 5, 2014
    Inventor: Gordhanbhai N. Patel
  • Publication number: 20140099233
    Abstract: The present disclosure provides a monitoring device comprising a test composition, a test element comprising a test portion to which the test composition is releasably adhered, a detection reagent, and a container comprising a first end with an opening and a second end opposite the first end. The test composition comprises a predetermined quantity of tracer analyte. The container is configured to receive the test portion and configured to be operationally coupled to an analytical instrument. The tracer analyte and the detection reagent each are capable of participating in one or more chemical reaction that results in the formation of a detectable product. A method of using the monitoring device to assess the efficacy of a washing process is also provided.
    Type: Application
    Filed: October 1, 2013
    Publication date: April 10, 2014
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: G. MARCO BOMMARITO, MANJIRI T. KSHIRSAGAR, TING LIU, TIMOTHY J. NIES, SWARNALATHA SWAMINATHAN
  • Patent number: 8679846
    Abstract: The invention provides a sterilization indicator (17), characterized in that it comprises: a compound (21) that is of the heating type when put into contact with atoms of oxygen O and/or nitrogen N; and a thermochromic dye (19), in thermal contact with the compound (21).
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: March 25, 2014
    Assignee: Societe pour la Conception des Applications des Techniques Electroniques
    Inventors: André Ricard, Francis Dieras, Michel Sixou, Sandrine Villeger, Cristina Canal, Pilar Erra
  • Patent number: 8647876
    Abstract: An oxygen permeability measuring apparatus for measuring an oxygen permeation rate of oxygen barrier film in a dark room is provided. A container is charged with inert gas, and sealed hermetically by use of the oxygen barrier film at least partially. A chemiluminescent compound is contained in the container, for emitting light by oxidation with the oxygen. A photon detector detects photons emitted by the chemiluminescent compound so as to determine an amount of the oxygen permeated through the oxygen barrier film. Preferably, the container includes a container body. An opening is formed in the container body, and closed hermetically by the oxygen barrier film attached thereto. The photon detector is disposed inside or outside the container. The oxygen permeation rate is equal to or less than 10?2 cc/m2·day·atm. The chemiluminescent compound includes tetrakis(dimethylamino)ethylene.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: February 11, 2014
    Assignee: Fujifilm Corporation
    Inventors: Tomoyuki Shimoda, Yoshio Inagaki, Kimiaki Miyamoto
  • Patent number: 8637264
    Abstract: Methods of using microarrays to simplify analysis and characterization of genes and their function are provided. Such methods can be used to identify and characterize antibodies having binding affinity for a specific target antigen. A method of determining gene expression at the protein level by contacting an array of characterized or uncharacterized antibodies on a solid surface with one or more proteins and identifying the antibodies to which said protein(s) binds also is provided. This method can be used to compare the protein expression in two different populations of cells, such as normal cells and cancer cells or resting cells and stimulated cells. In addition, a method of determining gene expression at the protein level by contacting a microarray of nucleic acid samples derived from a variety of different sources with one or more nucleic acid probes then identifying the sample or samples to which the probe binds is provided.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: January 28, 2014
    Assignee: Life Technologies Corporation
    Inventors: James P. Hoeffler, Joseph M. Fernandez, Marc S. Nasoff
  • Patent number: 8628968
    Abstract: An indicator composition for indicating that an article has undergone an ethylene oxide sterilization process is provided. The indicator composition includes at least one pyridine derivative that reacts with moist ethylene oxide to provide an irreversible color change of the composition.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: January 14, 2014
    Assignee: La-Co Industries, Inc.
    Inventor: Shobha Shakher Puntambekar
  • Publication number: 20140004609
    Abstract: The present invention describes the development of a measuring method based on the degradation of various chromophores/fluorophores that can be used as a quantitative method to elucidate the UV dose within a liquid or as a qualitative visual color-changing chemical indicator of UV sterilization is described.
    Type: Application
    Filed: June 24, 2013
    Publication date: January 2, 2014
    Inventors: Randall B. Pugh, Edward R. Kernick, Karson S. Putt, Terry O'Brien
  • Patent number: 8577491
    Abstract: Transport scheduling and transport processes for low microbial (“LM”) bulk products are described. The transport scheduling and processes facilitate low microbial activity in a LM bulk product during the transport of the LM bulk product.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: November 5, 2013
    Assignee: ConAgra Foods Food Ingredients Company, Inc
    Inventors: Robert Mariniello, Edith D. Akins-Lewenthal, Benjamin Warren, Ryan T. Grace
  • Patent number: 8577490
    Abstract: Transport scheduling and transport processes for low microbial (“LM”) bulk products are described. The transport scheduling and processes facilitate low microbial activity in a LM bulk product during the transport of the LM bulk product.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: November 5, 2013
    Inventors: Robert Mariniello, Edith D. Akins-Lewenthal, Benjamin Warren, Ryan T. Grace
  • Patent number: 8577492
    Abstract: Transport scheduling and transport processes for low microbial (“LM”) bulk products are described. The transport scheduling and processes facilitate low microbial activity in a LM bulk product during the transport of the LM bulk product.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: November 5, 2013
    Inventors: Robert Mariniello, Edith D. Akins-Lewenthal, Benjamin Warren, Ryan T. Grace
  • Patent number: 8546097
    Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: October 1, 2013
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Leo Martis, Mehul Patel, Joseph A. Giertych, James W. Mongoven, Jacqueline A. Kunzler, William F. Owen, Jr.
  • Publication number: 20130252340
    Abstract: The method comprises the following steps: bonding at least one chemical, optically luminescent compound (3) onto at least one indicator element (6) for testing the treatments (14), wherein at least one luminescence property of the chemical compound (3) can be changed; assigning at least one indicator element (6) to the object (1); wherein the indicator element (6) and the object (1) are simultaneously subjected to the same conditions of the energy-introducing treatment (14); changing the luminescence property of the chemical compound (3), wherein the level of the change to the luminescence property depends upon the energy-introducing treatment (14); irradiating (13) the chemical compound (3) with electromagnetic radiation directed onto the indicator (6) for excitation of the luminescence during the energy-introducing treatment or following the energy-introducing treatment (14).
    Type: Application
    Filed: November 28, 2011
    Publication date: September 26, 2013
    Inventors: Thomas Haertling, Anton Mayer, Jörg Opitz, Jürgen Schreiber, Susan Derenko, Christiane Wetzel
  • Patent number: 8541195
    Abstract: A testing unit and a method of testing a sterilization packaging unit for microbial contamination of sterilized objects after they have been sterilized are disclosed. The testing unit includes a dry matrix for accommodating a nutrient medium and a receptacle containing a liquid. By applying the liquid onto the matrix, the matrix is provided with a nutrient medium. In the method, the testing unit is inserted into the sterilization packaging unit which is sterilized and stored. At a desired point in time, the receptacle is opened in order to produce the nutrient medium in the matrix. After a possible multiplication of microbes on the matrix, an observation of microbes takes place. The invention also relates to a sterilization packaging unit which has a rigid outer casing and is suitable for the application of the method.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: September 24, 2013
    Inventor: Hartmut Dunkelberg
  • Publication number: 20130224866
    Abstract: A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent. The indicator includes a substrate and a microporous layer disposed on the substrate. The microporous layer is made from a polymer material having an index of refraction from about 1.25 to about 1.6 and is configured to change from a substantially opaque state to a substantially transparent state upon exposure to an antiseptic solution. The microporous layer resumes the substantially opaque state after a period of time.
    Type: Application
    Filed: April 18, 2013
    Publication date: August 29, 2013
    Applicants: Baxter International Inc.
    Inventors: Baxter International Inc., Baxter Healthcare S.A.
  • Patent number: 8517835
    Abstract: A video game controller with a position sensor and a proximity sensor provides user input signals for use in determining game states. The video game controller can have a board or deck like surface similar to that of a skateboard, and the proximity sensor can be used to determine if a grab of the board has been attempted. A video game associated with the video game controller can provide a skateboard or other game in which a skateboard and skateboarding character are responsive to a game player's manipulation of the video game controller.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: August 27, 2013
    Assignee: Activision Publishing, Inc.
    Inventors: Patrick Dwyer, Nick Ehrlich, Matt Knowles, Scott Krager, Arnab Sen, David M. Tibbetts, Joshua Tsui, Peter J. Sauerbrei
  • Publication number: 20130210153
    Abstract: A pouch (2) includes: a first, inner, envelope (1) which is closed, delimiting a first space (6) forming a pouch stricto sensu (1) intended for receiving a biopharmaceutical product or device; a second, outer, envelope (8) which is closed, delimiting a second space (9) in which is located the first envelope/pouch stricto sensu (1); a spacer element (11); at least one tracer gas located in the first space (6) or in the intermediate space (14) at a partial pressure different from that of the intermediate space or of the first space; and at least one colorimetric detection layer (12), responding to the concentration of tracer gas which reaches it by changing from a first color to a second color, and being an integral part of a wall (3, 4) of the first envelope/defined pouch (1) and/or of a wall (13) of the second envelope and/or of the spacer element.
    Type: Application
    Filed: August 22, 2011
    Publication date: August 15, 2013
    Applicant: SARTORIUS STEDIM BIOTECH S.A.
    Inventors: Lars Bottcher, Martin Dahlberg
  • Patent number: 8497080
    Abstract: The method of the invention pertains to determining signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: July 30, 2013
    Assignees: HistoRx, Inc., Yale University
    Inventors: Mark Gustavson, Jennifer Giltnane, Marisa P. Dolled-Filhart, Robert L. Camp, David L. Rimm
  • Patent number: 8497129
    Abstract: A medical instrument including a body member and an indicator component. The indicator component includes a mechanism for identifying when reprocessing of the medical instrument has occurred.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: July 30, 2013
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventor: Aaron C. Voegele
  • Patent number: 8492162
    Abstract: An electronic system for tracking and monitoring articles to be subjected to a sterilization cycle is disclosed. The method uses a sterilization indicator and electronically links sterilization information with the articles subjected to the sterilization process. The indicator allows a sterilization cycle to be monitored without the need for a user to subjectively distinguish between color, quality or intensity of display patterns.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: July 23, 2013
    Assignee: 3M Innovative Properties Company
    Inventors: Roland C. Kippenhan, Steven S. Kirckof, Philip A. Bolea, Richard M. Rumble, Rodney K. Hehenberger, Ramon T. Ignacio
  • Patent number: 8470601
    Abstract: An apparatus for indicating biological content within a container is provided. The apparatus includes a medical sterilization container having a cover removably attached to the medical sterilization container. An enclosable, sterilizable interior compartment is formed by the medical sterilization container and the cover, wherein the interior compartment is sized to house at least one medical instrument. A biological indicator is located at least partially in communication with the interior compartment, wherein the biological indicator provides at least one indication of biological content within the interior compartment after the medical sterilization container and cover are subjected to a sterilization process.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: June 25, 2013
    Assignee: Symmetry Medical Manufacturing, Inc.
    Inventors: Tony Foley, Gary T. Dane
  • Patent number: 8431077
    Abstract: This invention concerns a hydrogen peroxide sterilization device, with injection of hydrogen peroxide vapor, provided with a vaporizer that feeds a sterilization chamber, with a dose that varies in function of the control performed by a computer or control unit. The vaporizer works with a pressure inferior to the atmospheric one and is heated by an electrical resistance heater, or by micro-waves. All the vaporization process is made in vacuum, by heat or ultra-sounds. The filling of the sterilant agent is made drop-by-drop by a capillary tube which transforms the liquid into a pulverized gas. The computer controls the electrical valve following the dosing pump from the pressure and/or temperature information that comes from various pressure and/or temperature sensors, whereby the pressure inside the chamber is maintained during the sterilization process in a constant predefined value, appropriate to use simple cellulose-base paper or paper composed to the packaging of the devices.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: April 30, 2013
    Inventor: Helder da Costa Goncalves
  • Patent number: 8420338
    Abstract: Disclosed herein are compositions and methods for measuring the level of MG53 found in a biological fluid as a biomarker for a disease or disorder, e.g., tissue damage, exercise capacity or a muscle-related disease or disorder. In addition, the invention relates to targeting the native MG53 found in the blood as a therapeutic approach.
    Type: Grant
    Filed: November 5, 2011
    Date of Patent: April 16, 2013
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Noah Weisleder, Jianjie Ma
  • Patent number: 8420335
    Abstract: The present invention provides a method of testing the ability of a test compound to bind to and optionally modulate the activity of a protein of the JMJD2 subfamily of Jumonji proteins. The method comprises incubating a test compound with a protein of the JMJD2 subfamily of Jumonji proteins, a co-factor of said protein and, optionally, a substrate for demethylation. The method of the invention can be used for screening large numbers of compounds to identify a group of compounds that are candidate compounds for clinical use for treatment of certain cancers especially prostate cancers. Other compounds that do not have activity in the screening assays can be eliminated from further consideration as candidate compounds. The method of the invention therefore has utility in the pharmaceutical industry.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: April 16, 2013
    Assignee: Kobenhavns Universitet
    Inventors: Paul Cloos, Karl Agger, Jesper Christensen, Klaus H. Hansen, Kristian Helin
  • Patent number: 8394597
    Abstract: The invention relates to a method for detecting endotoxins in a sample.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: March 12, 2013
    Assignee: Hyglos Invest GmbH
    Inventors: Roman Meyer, Michael Schütz, Holger Grallert, Renate Grassl, Stefan Miller
  • Patent number: 8389225
    Abstract: The present invention relates to a bio-silica chip comprising a silica-binding protein and a fabrication method thereof, and more particularly to a bio-silica chip in which a fusion protein of a silica-binding protein and a probe protein is immobilized on a chip comprising a silica layer, a fabrication method thereof and a method of using the bio-silica chip to detect interactions with biomaterials. The bio-silica chip will be very useful in biosensors, etc., because the bio-silica chip is advantageous in that it does not cause non-specific protein binding in the detection of protein-DNA, protein-ligand, protein-antibody, protein-peptide, protein-carbohydrate, protein-protein and cell-biomaterial interactions. Also, in the method for fabricating the bio-silica chip, a probe chip can be selectively immobilized on a silica device chip, which is widely used in biosensors, without a chemical surface treatment process.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: March 5, 2013
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Sang Yup Lee, Tae Jung Park, Yang Kyu Choi, Bon Sang Gu, Jae Hyuk Ahn
  • Patent number: 8372594
    Abstract: The present invention relates to the use of protein expression profiles of sPLA2 isoforms with clinical relevance to osteoarthritis (OA). In particular, the invention provides methods for diagnosing OA or determining risk factors for development of OA based on expression of sPLA2-IIA.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: February 12, 2013
    Assignees: Case Western Reserve University, Brigham and Womens Hospital, The University of Washington
    Inventors: David M. Lee, Eric Boilard, Michael H. Gelb, Reuben Gobezie
  • Patent number: 8372593
    Abstract: The invention provides methods and kits for detecting conformationally altered proteins, such as prions or other proteins associated with disease states, in a sample. The methods comprise selectively capturing and separating complexes of peptide and conformationally altered protein from substances that interfere with detection of such complexes, and preferably amplification of the detection signal b addition of a second double-labeled peptide.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: February 12, 2013
    Assignee: Adlyfe, Inc.
    Inventors: Cindy S. Orser, Tao Pan, Jasmeet Sethi
  • Patent number: 8367351
    Abstract: The method of the invention pertains to determining the signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: February 5, 2013
    Assignees: Historx, Inc., Yale University
    Inventors: Mark Gustavson, Jennifer Giltnane, Marisa P. Dolled-Filhart, Robert L. Camp, David L. Rimm
  • Patent number: 8361742
    Abstract: A method and system for rapidly detecting Candida on the skin of a host, such as an infant with diaper rash, is provided. The method includes contacting a dermal sample with a colorant that exhibits a certain spectral response (e.g., color change) in the presence of Candida. For example, the colorant may change from a first color to a second color, from colorless to a color, or from a color to colorless. The colorant is typically capable of differentiating between Candida (e.g., Candida albicans) and other microorganisms commonly associated with diaper rash, such as S. aureus and E. coli. Thus, when a dermal sample is placed into contact with the colorant, the color change may simply be observed to determine whether the infection is caused by Candida. If the color change occurs to a certain extent (e.g., from yellow to bright red), it may be determined that the test sample contains Candida. Likewise, if a color change occurs to a lesser extent (e.g.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: January 29, 2013
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Stephanie M. Martin, Andrew M. Long, III, John Gavin MacDonald, Jason Lye