Abstract: The present invention relates to a method for solubilizing 5-amino-2,3-dihydro-1,4-phthalazinedione or salts thereof, to the solubilisate produced by this method and respective uses in pharmaceutical dosage forms. A phosphatidylcholine-based solubilization method is disclosed.

Abstract: The present invention relates to a dynamic chemical network that mimics the transfer of information and ultimately produces a chemical response, for example a readable signal. More specifically, the invention discloses a dynamic system able to selectively sense a biologically-relevant analyte, such as cysteine, in its reduced or its oxidized form (cystine) in aqueous media and in a biofluid (such as urine) for diagnostic application. Due to this property, said dynamic system is useful for the detection of cysteine or its derivatives in biological fluids such as urine.

Abstract: A photometric method for determination of a concentration of a film forming amine in a liquid, including providing a buffer solution of a weak acid having a pKa?4.5 and a strong acid having a pKa?1; diluting an aliquot of the buffer solution with water, and determining the pH of the diluted buffer solution; adding reagent to the diluted buffer solution and measuring an initial absorbance of the diluted buffer/reagent solution; preparing a sample solution by adding liquid containing the film forming amine to an aliquot of the buffer solution and measuring the pH of the sample solution; adjusting the pH of the sample solution to match the pH of the diluted buffer solution by adding strong acid; and adding the reagent to the pH adjusted sample solution to form a colored complex, and measuring the absorbance of the resulting solution in a photometer.

Abstract: Compositions comprising a polymeric dye and a cyclodextrin are provided. Methods associated with preparation and use of such compounds, for example in methods for detection of any analyte molecule, are also provided.

Abstract: A method for the in situ derivatization of at least one biogenic amine, precursor, or metabolite thereof in an isolated aqueous sample includes the steps of: (i) contacting the sample with a propionic anhydride/acetonitrile solution in the presence of a phosphate buffer having a pH in the range of 7.0 to 9.0 and allowing the conversion of amine and/or hydroxyl moieties of the biogenic amine, precursor, or metabolite thereof to form a propionyl derivative of the biogenic amine; followed by (ii) adding to the reaction mixture obtained in step (i) a carbodiimide compound and an electrophilic amine-containing compound, and allowing the carbodiimide-mediated derivatization of carboxylic acid moieties of the biogenic amine, precursor, or metabolite thereof.

Abstract: A functional material includes a porous metal-organic framework (MOF) including an organic ligand derived from benzenedicarboxylic acid and a metal ion cluster coordination-bonded with the organic ligand, and a luminescent molecule in pores of the MOF.

Abstract: A method for preparing a ratiometric fluorescent probe for cymoxanil based on a double-emission quantum dot-silver nanoparticle complex, wherein, the double-emission carbon quantum dots and the silver nanoparticles are prepared, and the inner filter effect occurring between the double-emission carbon quantum dots and the dispersed silver nanoparticles causes the blue fluorescence quenching of the carbon quantum dots. However, the specific binding of cymoxanil to silver nanoparticles causes the silver nanoparticles to accumulate, and then the inner filter effect occurring between the double-emission carbon quantum dots and the dispersed silver nanoparticles causes the green fluorescence quenching of carbon quantum dots. In this regard, the linear relationship between the intensity ratio of two fluorescent emission peaks of carbon quantum dots and the molar concentration of cymoxanil is established, and the ratiometric fluorescent probe for cymoxanil is constructed.

Abstract: The present disclosure provides Molecularly Imprinted Polymer (MIP) technology for selectively sequestering one or more target molecules from chemical mixtures. Also disclosed herein are MIP beads and methods of making and using thereof.

Abstract: Provided are a method for analyzing nitrogen in a metal sample, an apparatus for analyzing nitrogen in a metal sample, a method for adjusting nitrogen concentration in molten steel, and a method for manufacturing steel. The method includes: a melting process in which a metal sample containing a nitrogen component is melted in an argon gas atmosphere by performing impulse heating to gasify the nitrogen component; and an analyzing process in which nitrogen content in the metal sample is determined by analyzing nitrogen gas generated in the melting process and the argon gas by using a gas discharge optical emission method. By analyzing the nitrogen concentration of a sample taken from molten steel by using the analysis method described above, and by determining treatment conditions for adjusting nitrogen concentration on the basis of the nitrogen analysis value derived by the analysis, nitrogen concentration in molten steel is adjusted.

Abstract: A method for active or passive sampling of particles and gas phase organic and non-organic components in a fluid flow (4) is disclosed, wherein said method comprises the step in which a sampling device comprising a first denuder device (1), a filter device (3), and a second denuder device (2), arranged in axial direction in a series in said order, is provided at a measurement spot, wherein the first denuder device (1) and the second denuder device (2) each is hollow and contains surfaces provided with a hydrophobic and/or a hydrophilic sorbent, or said second denuder device (2) contains a packing of hydrophobic and/or hydrophilic sorbent particles, as well as a sampling device used in said method.

Abstract: Methods for diagnosing, treating, and monitoring the treatment of Clostridium difficile infections (CDI), e.g., Clostridium difficile-Associated Diarrhea (CDAD). The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in a sample from ambient air or stool sample from subjects suspected of having a CDI, e.g., CDAD.

Abstract: A method for removing one or more processing by-products found in deposition systems, such as in vacuum forelines of vapor deposition systems is provided. The method comprises performing a deposition process to deposit a layer on a substrate positioned in a deposition chamber. Hydrogen-containing by-products are produced in a vacuum foreline fluidly coupled with the deposition chamber during the depositing process. The method further comprises flowing an oxidizing agent gas into the vacuum foreline to react with at least a portion of the hydrogen-containing by-products in the foreline.

Abstract: The present disclosure provides methods and structures for systems which can linearize and capture a nucleic acid molecule (e.g., DNA) for re-measurement of the nucleic acid molecule or other polymer prior to detection of the polymer. The structures may allow for quick exchange between different samples or other reagents.

Abstract: A method of marking a batch of carbon dioxide including creating by a traceability computer system at least one reference for a batch of carbon dioxide, in a database of a computer system listing a plurality of batches of carbon dioxide; injecting a chemical tracer into the batch of carbon dioxide, the final concentration of the tracer in the batch being less than 1% by mass; and recording the chemical tracer formula in the traceability computer system. The formula of the chemical tracer for the batch is associated with a batch reference in the database, the chemical tracer formula having the form of a combination of proportions of at least two chemical substances.

Abstract: The invention is directed to dual-analyte fluorescent chemosensors for the direct detection and visualization (imaging) of neurotransmitters released upon exocytosis. The inventive sensor exploits the high concentration of neurotransmitters (e.g., glutamate, norepinephrine, and dopamine) and capitalizes upon the pH gradient between the vesicle and synaptic cleft.

Abstract: Apparatus and methods in accordance with one or more preferred embodiments of the present invention are used to measure nitric oxide in a fluid, and each includes a sample injection port; a pump; a measurement chamber; an electromagnetic radiation source; one or controls and user interfaces; and a cartridge. The cartridge includes a sample chamber; an electromagnetic radiation and heat chamber; and a gas permeable membrane. The cartridge preferably is single-use and disposable. Further apparatus and methods in accordance with other alternative embodiments, and additional inventive aspects and features, are disclosed related to measuring nitric oxide in a fluid.

Abstract: Deuterium free, stable isotope labeled hallucinogens and/or stimulants containing a 2-phenylethylamine-based structural unit and containing at least three stable isotopes selected from the group consisting of 13C, 15N and 18O as free bases and as their salts; method of their preparation and their use in the chemical analysis, in particular forensic chemical analysis, and in metabolic studies.

Abstract: Method comprising the steps of obtaining a sample of a return drilling fluid, the return drilling fluid containing a tagged detectable additive, the tagged detectable additive comprising a polymer comprising at least one chemical tag bonded to the polymer; and determining a concentration of the tagged detectable additive in the return drilling fluid based on a spectroscopic signal of the sample. The tagged detectable additive may include a polymer comprising at least one chemical tag bonded to the polymer.

Abstract: A method for testing a condition of a catalyst is provided. The method includes providing a gas source in communication with the catalyst. The method also includes passing compressed gas from the gas source over the catalyst at normal operating temperature. The method further includes invoking a reaction with the catalyst based on the passage of the compressed gas. The method includes measuring a performance of the catalyst based on the reaction.

Abstract: Devices, methods and systems for detecting nitro-containing compounds such as TNT, which utilize semiconductor nanostructures modified by a functional moiety that interacts with the nitro-containing compound, are disclosed. The functional moiety is attached to the nanostructures and is being such that upon contacting a sample that contains the nitro-containing compound, the nanostructure exhibits a detectable change in an electrical property, which is indicative of the presence and/or amount of the nitro-containing compound in the sample. Electronic noses for generating recognition patterns of various nitro-containing compounds, made of a plurality of nanostructures modified by versatile functional moieties are also disclosed. The devices, methods and systems are suitable for detecting nitro-containing compounds in both liquid and gaseous states and for detecting a concentration of a nitro-containing compound such as TNT as low as attomolar concentrations.

Abstract: Methods and materials for the detection of melamine in test samples such as foodstuffs are described. Embodiments of the invention comprise combining a test sample suspected of containing melamine with a particle that produces a colorimetric and/or turbidimetric signal that is dependent upon the concentration of melamine in the test sample. In certain embodiments of the invention, the particles and test sample are combined together with a chemical compound selected to induce the aggregation melamine in a manner that amplifies the colorimetric and/or turbidimetric signal of the assay. In some embodiments of the invention, the aggregation inducing agent is not physically coupled to the particles used in the assays. In other embodiments of the invention, the aggregation inducing agent is physically coupled to the particles used in these assays.

Abstract: The present invention relates to a method for processing a wax-embedded biological sample, the use of poly(organosiloxane)s for liquefying the embedding medium of a wax-embedded biological sample and a kit for processing a wax-embedded biological sample.

Abstract: The present invention provides methods for preventing clumping of cells in microfluidic devices by addition of diazolidinyl urea (DU). DU can be added to samples at the time of collection or can be added to samples post-collection. DU can also be pre-added to sample collection devices.

Abstract: Sensors and methods for determination of analytes are provided. Analytes including explosives (e.g., RDX or PETN) may be determined by monitoring, for example, a change in an optical signal of a material upon exposure to the analyte. In some embodiments, the analyte and the material may interact via a chemical reaction to form a new emissive species. Embodiments described herein may provide inexpensive sensors with high selectivity and sensitivity.

Abstract: Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and processes associated therewith in live cells.

Abstract: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.

Abstract: A method of determining the solubility of a compound in a selected solvent is provided that does not require determination of, or use of, standards having known concentrations of the compound. In one aspect, the method can include preparation of a mixture where not all of a compound is dissolved in the provided solvent, separating undissolved compound from the solvent, and direct determination of the amount of the compound dissolved in the solvent. Methods adapted for use include those where a multiplicity of compounds or solvents are tested in parallel. Devices adapted for these methods are also provided by the present disclosure.

Abstract: Disclosed herein are chromogenic response polymers and methods and devices that utilize the disclosed polymers which are suitable for use in detecting the presence of and identity of biogenic amines.

Abstract: The present application describes a sensor apparatus, especially an electronic nose, based on 2D films or 3D assemblies of cubic nanoparticles capped with an organic coating. The organic coating is modified with unique compositions of functional moieties, e.g. cyclodextrins, to provide the detection of volatile and non-volatile compounds derived from explosive materials, e.g. PETN, RDX, TNT etc. with very high sensitivity. The nose employs pattern recognition algorithms and methods, e.g. PCA, for detecting and quantifying specific explosive compounds.

Abstract: Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.

Abstract: An ammonia compound concentration measuring device includes: a pipe unit through which the circulating gas flows; a converter which is disposed in the pipe unit and converts an ammonia compound into ammonia; a measurement device which measures a first measurement value as a concentration of ammonia contained in a first circulating gas flowing inside a pipe line passing through the converter in the circulating gas flowing inside the pipe unit and a second measurement value as a concentration of ammonia contained in a second circulating gas flowing inside a pipe line not passing through the converter in the circulating gas flowing inside the pipe unit; and a controller which controls operations of the pipe unit and the measurement device and calculates the concentration of the ammonia compound of the measurement subject contained in the circulating gas from a difference between the first measurement value and the second measurement value.

Abstract: The present invention provides a nanohybrid type nitrogen monoxide detecting sensor and a production method therefor in which the nanohybrid type nitrogen monoxide detecting sensor includes a fluorescent semiconducting quantum dot and a transition metal compound. Employing a nanohybrid structure including semiconducting quantum dot nano-particles combined with a molecule recognizer selectively forming a bonding to nitrogen monoxide, the nitrogen monoxide detecting sensor is enabled to detect an infinitesimal amount of nitrogen monoxide by bringing about photoluminescence upon detection of nitrogen monoxide.

Abstract: The present invention relates generally to a kit and method for the colorimetric detection of precursors used in the assembly of homemade explosives (HMEs). More specifically, the present invention relates to a bulk HME precursor detection kit and methods of using a kit that is capable of bulk detection of HME precursors, such as urea nitrate, ammonium nitrate and potassium chlorate.

Abstract: The invention provides methods for isolating a target molecule from a sample. In an embodiment, the method involves contacting a sample with a capture agent, the agent comprising a siderophore and a transition metal cation, under conditions wherein the agent is capable of binding a target molecule to form a target molecule-capture agent complex, wherein the target molecule is selected from the group consisting of a phosphorylated molecule, a nitrotyrosine-containing molecule and a sulfated molecule, and separating the target molecule-capture agent complex from the sample, thereby isolating the target molecule from the sample. Also provided are methods for determining the presence of a target molecule in a sample, that involve contacting a sample with a capture agent, the agent comprising a siderophore and a transition metal cation.

Abstract: A urea solution quality determining system may include a urea tank in which a urea solution is filled through a charging hole, a test chamber positioned below the charging hole for holding a portion of the urea solution, a main line connected to the urea tank at a lower part of the urea tank below the test chamber, a test line connected to the test chamber, a pumping line to which the main line and the test line are joined, a pump in the pumping line to pump the urea solution from the test chamber or from the urea tank, a control valve for selectively connecting the main line or the test line to the pumping line, and an injector at an end of the pumping line to inject the urea solution into an exhaust line through which an exhaust gas flows. A method is also described.

Abstract: The compositions and methods relate to an organic polymer-inorganic particle sensor material for detecting analytes. Interactions between the polymer and the particles are affected by the presence of analyte, which displaces the polymer and increases its free volume. This change in free volume can be detected, e.g., using an embedded piezoresistive microcantilever (EPM) sensor. Analytes that can be detected include noxious substances, such as hydrogen cyanide gas and carbon monoxide.

Abstract: A chemochromic indicator is provided that includes a hypergolic fuel sensing chemochromic pigment that change from a first color to a second color in the presence of a hypergolic fuel. In a first embodiment, a chemochromic indicator is provided for detecting the presence of a hypergolic fuel such that the irreversible hypergolic fuel sensing chemochromic pigment includes potassium tetrachloroaurate (KAuCl4). There are several types of chemochromic indicators, for example, the article used to form the chemochromic indicators include, but are not limited to, wipe materials, silicone/TEFLON tape, manufactured parts, fabrics, extruded parts, and paints.

Abstract: A microchannel chip having a microchannel formed in a substrate and a gas-liquid phase separation microchannel whose upper part is covered with a porous film, the gas-liquid phase separation microchannel being connected to the downstream end of the microchannel and having a depth of 10 ?m to 100 ?m. Also, a gas-liquid phase separation method which is a method for separating a liquid-phase flow from a two-phase flow flowing through a microchannel by removing a gas phase, the two-phase flow composed of the gas phase and the liquid phase, which liquid phase flows in the periphery of the above-described microchannel and which gas phase flows interiorly of the liquid-phase flow.

Abstract: A fluorescence based sensor (10) is disclosed and described. The sensor (10) can include nanofibril materials (12) fabricated from a linear carbazole oligomer and a fluorescence detector (14). The linear carbazole oligomer can have the formula (I) wherein n is 3 to 9, R are independently selected amine sidegroups, and at least one, but not all, R is a C1 to C14 alkyl. The carbazole-based fluorescence based sensors (10) can be particularly suitable for detection of explosives and volatile nitro compounds.

Abstract: A method for identifying gambiered Guangdong silk includes the steps of: detecting the surface state of fiber by microscope; detecting the pyrolysis fragments of fabrics by pyrolysis gas chromatography; determining the crude protein content in the fiber by Kjeldahl determination; and detecting the dye component of the fabrics by high performance liquid chromatography. The method of the present invention can accurately identify the true and fake, good and bad of the gambiered Guangdong silk, and then make an accurate evaluation on the gambiered Guangdong silk; and the present invention is simple, useful, environmental and has low cost.

Abstract: The invention provides a method of assaying for tetrahydrocannabinol in a body fluid. The method includes contacting a sample of body fluid with an imine capable of reacting with tetrahydrocannabinol to yield a quinone imine, and detecting the formation of a quinone imine, where the sample is contacted with the reagent compound at a pH of at least 10.5.

Abstract: A dissolved nitrogen concentration monitoring method is used for monitoring a dissolved nitrogen concentration of a cleaning liquid when an ultrasonic wave is irradiated onto the cleaning liquid in which a substrate is dipped. The method includes measuring an amount of increase of a dissolved oxygen concentration of the cleaning liquid resulting from an oxygen molecule generated from a water molecule as a result of a radical reaction caused by ultrasonic wave irradiation. A dissolved nitrogen concentration of the cleaning liquid is calculated from the measured amount of increase of dissolved oxygen concentration based on a predetermined relationship between a dissolved nitrogen concentration and an amount of increase of dissolved oxygen concentration.

Abstract: Provided herein are explosives detection substrates which include an electrospun (electro)sprayed and/or dry spun aromatic polymer, such as polystyrene, and a small molecule fluorophore. Methods for detecting an explosive material using such substrates are also provided.

Abstract: A sterilization indicator having a compound that is of the heating type when put into contact with atoms of oxygen O and/or nitrogen N; and a thermochromic dye, in thermal contact with the compound.

Abstract: A control system of a NOx removal device is provided with reagent introducing means for introducing a reagent into a fluid, a temperature measuring device that measures a temperature distribution of the fluid, a reagent-concentration calculating portion that calculates a concentration distribution of the reagent introduced into the fluid with the temperature distribution determined at the temperature measuring device, a reagent-flow-rate determining portion that determines a flow rate of the reagent that the reagent introducing means introduces in accordance with the concentration distribution calculated at the reagent-concentration calculating portion, and a reagent-introducing-means control portion that controls the reagent introducing means so as to introduce the reagent into the fluid at the flow rate determined at the reagent-flow-rate determining portion.

Abstract: Technologies are generally described for gas filtration and detection devices. Example devices may include a graphene membrane and a sensing device. The graphene membrane may be perforated with a plurality of discrete pores having a size-selective to enable one or more molecules to pass through the pores. A sensing device may be attached to a supporting permeable substrate and coupled with the graphene membrane. A fluid mixture including two or more molecules may be exposed to the graphene membrane. Molecules having a smaller diameter than the discrete pores may be directed through the graphene pores, and may be detected by the sensing device. Molecules having a larger size than the discrete pores may be prevented from crossing the graphene membrane. The sensing device may be configured to identify a presence of a selected molecule within the mixture without interference from contaminating factors.

Abstract: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.

Abstract: A ninhydrin reagent for use in a method for analysing nitrogen-containing compounds, in particular visualising nitrogen-containing compounds by a colour forming reaction, is provided, the ninhydrin reagent comprising ninhydrin; an aqueous buffer; and a temperature-dependent reducing agent, which agent is inactive in the reduction of ninhydrin at a first temperature and active in reducing ninhydrin to hydrindantin at a second temperature, wherein the second temperature is higher than the first temperature. The reagent is particularly useful in the analysis of amino acids.

Abstract: Disclosed herein is a method for diagnosing hepatic cancer by analysing a sample and determining the level of at least one compound selected from the group consisting of glycine, trimethylamine-N-oxide, hippurate and citrate and comparing the levels in the sample with control levels. The analysis of the sample can involve the determination of a profile for the sample. The methods disclosed are useful in distinguishing between a patient having hepatic cancer and a patient having cirrhosis.

Abstract: The invention relates to a device for producing CO2, N2 and/or SO2 from a sample for a quantitative analysis of the sample, comprising a reactor structure and metals acting in an oxidizing manner or metal oxides in the reactor. According to the invention, the reactor structure has at least two zones through which the sample can flow, which is to say a first zone with reactor metal and reservoir metal, or only reactor metal, and following the first zone, a second zone with reactor metal and reservoir metal, or only reservoir metal, wherein both metals can form oxides, and wherein the ratio of the reactor metal to the reservoir metal in the first zone is greater than in the second zone.