Amine And Quaternary Ammonium Patents (Class 436/111)
  • Patent number: 10365277
    Abstract: Disclosed is a novel method for measuring haemagglutinin of an influenza virus, which can construct an assay system in a shorter period of time than a sandwich immunoassay method using two kinds of anti-haemagglutinin antibodies. The method for measuring haemagglutinin of an influenza virus is achieved by a sandwich immunoassay method comprising sandwiching the haemagglutinin between a lectin which binds to the haemagglutinin but does not bind to an antibody, and an anti-haemagglutinin antibody which undergoes antigen-antibody reaction with the haemagglutinin.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: July 30, 2019
    Assignee: DENKA SEIKEN CO., LTD.
    Inventors: Ryotaro Mitsumata, Noriyuki Izutani
  • Patent number: 10241013
    Abstract: Systems and methods for inline and automatic dilution of chemicals of interest for speciation and subsequent analysis by ICP spectrometry are described. A system embodiment includes a first valve to receive a sample into a holding loop; a plurality of syringe pumps coupled to the first valve to deliver an inline diluted sample from the first valve; and a second valve coupled to the first valve to receive the inline diluted sample from the first valve into a sample holding loop coupled to the second valve, the second valve configured to couple to at least one of an eluent source or a carrier fluid source to receive at least one of an eluent fluid or a carrier fluid to transfer the inline diluted sample from the sample holding loop to a speciation column to separate one or more species from the inline diluted sample.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: March 26, 2019
    Assignee: ELEMENTAL SCIENTIFIC, INC.
    Inventors: Paul Field, Daniel R. Wiederin, Patrick Sullivan
  • Patent number: 10203344
    Abstract: Compounds include carbamate derivatives of vitamin D including vitamin D3 and vitamin D2. The compounds are useful in methods and kits for determining the presence and/or amount of vitamin D including vitamin D analogs and metabolites thereof in a sample suspected of containing the same.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: February 12, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Zhu Teng, Roland Janzen, Martin A. Drinan
  • Patent number: 9606033
    Abstract: According to an embodiment of an autosampler, a sample rack provided with a thermal conductive plate holder on whose upper surface a sample plate is to be set is set on a rack setting section. A cooling device for cooling the plate holder is provided. A plate detection section for detecting whether a sample plate is set on the plate holder of the sample rack that is set on the rack setting section is provided, and when a sample plate is not set on the plate holder of the sample rack that is set on the rack setting section, the output of the cooling device for cooling the plate holder is turned off.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: March 28, 2017
    Assignee: SHIMADZU CORPORATION
    Inventor: Yoshiaki Maeda
  • Patent number: 9587035
    Abstract: The invention relates to the detection and quantification of 1-benzylpiperazine and its metabolites. The invention is underpinned by novel polyclonal antibodies with unique binding properties which enable immunoassay methods and kits for various applications.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: March 7, 2017
    Assignee: Randox Laboratories Limited
    Inventors: Elouard Benchikh, Ivan McConnell, Philip Lowry, Peter Fitzgerald
  • Patent number: 9541543
    Abstract: Various methods for determining whether a subject has alcoholic hepatitis are described. In one aspect, a method for determining whether a subject has alcoholic hepatitis is described. The method includes determining the levels of a trimethylamine in a biological sample obtained from the subject. The level of trimethylamine in the biological sample is compared to the control value, and the subject whose level of trimethylamine exceeds the control value is diagnosed as having alcoholic hepatitis. In another aspect of the present invention a method for assessing a subject as having alcoholic hepatitis (AH) includes determining the level of trimethylamine and the level of pentane in a biological sample obtained from the subject. A TAP score is determined based on the concentration of trimethylamine and the concentration of pentane. The subject is diagnosed as having alcoholic hepatitis if the TAP score exceeds a control value.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: January 10, 2017
    Assignee: The Cleveland Clinic Foundation
    Inventors: Raed Dweik, Ibrahim Hanouneh, Nizar Zein, David Grove, Frank S. Cikach, Jr.
  • Patent number: 9470692
    Abstract: The disclosure provides a method for assaying for a target analyte, comprising providing a plurality of samples which may comprise the target analyte, wherein each sample is differentially labelled with a mass label or a combination of mass labels, wherein the mass labels are from a set of mass labels, wherein each mass label is an isobaric mass label comprising a mass spectrometrically distinct mass marker group, such that the samples can be distinguished by mass spectrometry and determining from the mass spectrum the quantity of the target analyte in each sample.
    Type: Grant
    Filed: May 18, 2009
    Date of Patent: October 18, 2016
    Assignee: ELECTROPHORETICS LIMITED
    Inventors: Christian Baumann, Helen Byers, Peter Schulz-Knappe, Malcolm Ward
  • Patent number: 9377410
    Abstract: A method for measuring a reaction rate of a reactive mesogen and an alignment layer formed thereby, the method including coating an alignment material on a substrate. The alignment material includes a backbone and a reactive mesogen connected to the backbone. The reactive mesogen includes an unsaturated bond. The alignment material is irradiated with ultraviolet light, or is heated, to form the alignment layer. A marking compound, including a thiol group is coated on the alignment layer and reacts with remaining unreacted reactive mesogen, to form a marked mesogen. An amount of the marked mesogen is detected. A reactive ratio is measured by comparing an amount of the reactive mesogen before irradiating or heating with an amount of the marked mesogen.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: June 28, 2016
    Assignee: Samsung Display Co., Ltd.
    Inventors: Ho Lim, Tae-Min Kim
  • Patent number: 9229007
    Abstract: Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula where R1-R4 independently are hydrogen hydroxyl, halogen, thiol, thioether, lower aliphatic, or lower alkoxy, x is an integer from 0 to 4, and each R5 independently is halogen, hydroxyl, thiol, thioether, lower aliphatic, or lower alkoxy. Embodiments of the disclosed probes are capable of undergoing condensation/cyclization reactions with cysteine and/or homocysteine. Cysteine and/or homocysteine can be selectively detected and identified by determining fluorescence emission of the probes at characteristic wavelengths.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: January 5, 2016
    Assignee: Portland State University
    Inventors: Robert Strongin, Xiaofeng Yang
  • Patent number: 9144620
    Abstract: The present disclosure generally relates to a color indicator that signals when the concentration of an antimicrobial solution changes. In some embodiments, the color indicator is specific for changes in the concentration of an antimicrobial quaternary ammonium compound in an antimicrobial solution. The color indicator can be incorporated into a variety of articles including towels, labels, containers, buckets, trays, sinks, spray bottles, liners for containers, buckets, sinks, or spray bottles, indicator wands or strips, and test kits.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: September 29, 2015
    Assignee: Ecolab USA Inc.
    Inventors: Eric Balz, Kim R. Smith, Erik C. Olson, Sherri Tischler
  • Patent number: 9040255
    Abstract: The present invention provides methods for preventing clumping of cells in microfluidic devices by addition of diazolidinyl urea (DU). DU can be added to samples at the time of collection or can be added to samples post-collection. DU can also be pre-added to sample collection devices.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: May 26, 2015
    Assignee: BIOCEPT, INC.
    Inventors: Pavel Tsinberg, Stephen D. Mikolajczyk
  • Publication number: 20150140676
    Abstract: Various methods for determining whether a subject has alcoholic hepatitis are described. In one aspect, a method for determining whether a subject has alcoholic hepatitis is described. The method includes determining the levels of a trimethylamine in a biological sample obtained from the subject. The level of trimethylamine in the biological sample is compared to the control value, and the subject whose level of trimethylamine exceeds the control value is diagnosed as having alcoholic hepatitis. In another aspect of the present invention a method for assessing a subject as having alcoholic hepatitis (AH) includes determining the level of trimethylamine and the level of pentane in a biological sample obtained from the subject. A TAP score is determined based on the concentration of trimethylamine and the concentration of pentane. The subject is diagnosed as having alcoholic hepatitis if the TAP score exceeds a control value.
    Type: Application
    Filed: January 13, 2015
    Publication date: May 21, 2015
    Inventors: Raed Dweik, Ibrahim Hanouneh, Nizar Zein, David Grove, Frank S. Cikach, JR.
  • Publication number: 20150132746
    Abstract: Provided herein is technology relating to the collection of biological samples and particularly, but not exclusively, to compositions, methods, and uses related to using a biopolymer substrate to collect biological samples for analysis.
    Type: Application
    Filed: May 29, 2013
    Publication date: May 14, 2015
    Inventors: Astrid Gjelstad, Lars Erik Eng Eibak, Anne Bee Hegge, Knut Einar Rasmussen, Stig Pedersen-Bjergaard
  • Publication number: 20150099306
    Abstract: A reading device for reading and analyzing a test cassette having an identification code includes a reading unit, used for reading the identification code marked by the test cassette and carrying out interpretation on a plurality of test lines of the test cassette; an operating unit, used for operating the reading device; a processing unit, used for interpreting a test result with the identification code and the test lines; and a display unit, used for displaying the test result of the test cassette.
    Type: Application
    Filed: April 7, 2014
    Publication date: April 9, 2015
    Inventor: HUI-CHI KU
  • Patent number: 8999722
    Abstract: Sensors and methods for determination of analytes are provided. Analytes including explosives (e.g., RDX or PETN) may be determined by monitoring, for example, a change in an optical signal of a material upon exposure to the analyte. In some embodiments, the analyte and the material may interact via a chemical reaction to form a new emissive species. Embodiments described herein may provide inexpensive sensors with high selectivity and sensitivity.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: April 7, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Trisha L. Andrew
  • Patent number: 8986998
    Abstract: Disclosed herein is a method for identifying the compounds contributing to a pungent odor from an air conditioner, a method for artificially reproducing the pungent odor, and preparing a corresponding pungent odor composition. Through the analysis method of the present invention, the compounds contributing to the pungent odor from an air conditioner may be identified and quantified. The pungent odor may be reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced pungent odor may provide significant data required for development of an apparatus and a method for removing specific odors.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: March 24, 2015
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim
  • Publication number: 20150080263
    Abstract: The present invention is directed to methods for predicting a pregnant woman's risk of carrying a fetus with Down syndrome (Trisomy 21) or Trisomy 18. The methods are based on measuring one or more metabolites obtained from a pregnant woman's bodily fluid, such as blood or urine, and found to be predictive of Trisomy 21 or Trisomy 18.
    Type: Application
    Filed: April 12, 2013
    Publication date: March 19, 2015
    Inventors: Ray O. Bahado-Singh, Kypros Nicolaides
  • Patent number: 8975014
    Abstract: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: March 10, 2015
    Assignee: The Regents of the University of California
    Inventor: Rebecca Braslau
  • Publication number: 20150065460
    Abstract: Biomarkers relating to pancreatic Beta-cell function, pancreatic Beta-cell glucose sensitivity, insulin resistance, and/or pancreatic Beta-cell-related disorders are provided. Methods based on the same biomarkers are also provided.
    Type: Application
    Filed: September 11, 2012
    Publication date: March 5, 2015
    Inventors: Walter Gall, Kay A. Lawton
  • Patent number: 8969083
    Abstract: A method that identifies the compounds contributing to a fish-like odor from an air conditioner and artificially reproduces the fish-like odor, and prepares a corresponding fish-like odor composition. Through the analysis method of the present invention, the compounds contributing to the fish-like odor from an air conditioner are identified and quantified. The fish-like odor is reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced fish-like odor provides significant data required for development of an apparatus and a method for removing specific odor.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: March 3, 2015
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim, Sang Jun Lee, Seok Man Kim
  • Publication number: 20150056712
    Abstract: Methods of analyzing purity of compositions comprising cysteamine and detecting impurities in cysteamine compositions are described.
    Type: Application
    Filed: June 17, 2014
    Publication date: February 26, 2015
    Inventors: Kathlene Powell, Ramesh Muttavarapu
  • Publication number: 20150038522
    Abstract: To provide an anti-cancer agent sensitivity determination marker, which marker can determine whether or not the patient has a therapeutic response to the anti-cancer agent, and novel cancer therapeutic means employing the marker. The anti-cancer agent sensitivity determination marker, the anti-cancer agent including oxaliplatin or a salt thereof and fluorouracil or a salt thereof, contains one or more substances selected from among an amino-acid-metabolism-related substance, a nucleic-acid-metabolism-related substance, a substance in the pentose phosphate pathway, a substance in the glycolytic pathway, a substance in the TCA cycle, a polyamine-metabolism-related substance, 7,8-dihydrobiopterin, 6-phosphogluconic acid, butyric acid, triethanolamine, 1-methylnicotinamide, NADH, NAD+, and a substance involved in the metabolism of any of these substances.
    Type: Application
    Filed: February 22, 2013
    Publication date: February 5, 2015
    Applicants: KEIO UNIVERSITY, KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Yusuke Tanigawara, Akito Nishimuta, Junya Tsuzaki, Hiroyuki Takahashi
  • Publication number: 20150017732
    Abstract: A colorimetric assay to detect certain compounds and a kit therefore are provided.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 15, 2015
    Inventors: Tsunghsueh Wu, Charles Cornett
  • Patent number: 8932870
    Abstract: A method for determining whether a subject has alcoholic hepatitis is described. The method includes determining the levels of a trimethylamine in a biological sample obtained from the subject. The level of trimethylamine in the biological sample is compared to the control value, and the subject whose level of trimethylamine exceeds the control value is diagnosed as having alcoholic hepatitis.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: January 13, 2015
    Assignee: The Cleveland Clinic Foundation
    Inventors: Raed Dweik, Ibrahim Hanouneh, Nizar Zein, David Grove, Frank S. Cikach, Jr.
  • Publication number: 20150011423
    Abstract: The present invention pertains to the field of diagnostics for kidney toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing kidney toxicity. It also relates to a method for determining whether a compound is capable of inducing such kidney toxicity in a subject and to a method of identifying a drug for treating kidney toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing kidney toxicity.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 8, 2015
    Applicant: BASF SE
    Inventors: Hennicke Kamp, Tilmann B. Walk, Bennard van Ravenzwaay, Werner Mellert, Eric Fabian, Volker Strauss, Jan C. Wiemer, Ralf Looser, Michael Manfred Herold, Alexandre Prokoudine
  • Patent number: 8927293
    Abstract: Disclosed herein are chromogenic response polymers and methods and devices that utilize the disclosed polymers which are suitable for use in detecting the presence of and identity of biogenic amines.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: January 6, 2015
    Assignee: University of South Carolina
    Inventors: John J. Lavigne, Toby Nelson, Marc Maynor
  • Patent number: 8921113
    Abstract: A buffer kit includes a first eluent and second eluent. The first eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The second eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The first eluent solution has a first pH and the second eluent solution has a second pH where the first pH and second pH are different values. The buffer kit provides a linear pH gradient that forms an approximately straight line from at least the first pH to the second pH.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: December 30, 2014
    Assignee: Dionex Corporation
    Inventors: Shanhua Lin, Christopher A. Pohl
  • Publication number: 20140322117
    Abstract: A method for detecting paths and amount of loss of desulfurization organic components in a flue gas desulfurization system includes preparing a to-be-measured solution and a base standard solution, and diluting the base standard solution with water to a plurality of standard solutions containing different concentrations of desulfurization organic components; adjusting the to-be-measured solution and standard solutions to have a strong acidity, respectively, such that each of desulfurization organic components in the to-be-measured solution and standard solutions exists in ion forms; heating and oscillating the to-be-measured solution and standard solutions, respectively; respectively detecting carbon elements in the standard solutions, to form a linear relationship between concentrations of the desulfurization organic components in the standard solutions and detected carbon element data; and detecting carbon elements in the to-be-measured solution, and obtaining a total concentration of the desulfurization or
    Type: Application
    Filed: April 25, 2014
    Publication date: October 30, 2014
    Applicant: Pangang Group Panzhihua Iron and Steel Research Institute Co., Ltd.
    Inventors: Yong Cheng, Jianming Li
  • Patent number: 8871438
    Abstract: The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of-flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: October 28, 2014
    Assignee: Korea Research Institute of Standards and Science
    Inventors: Tae Geol Lee, Dae Won Moon, Byong Chul Yoo, In Hoo Kim
  • Publication number: 20140287514
    Abstract: The present invention includes a sensing device and method detecting the presence of a chemical analyte, comprising: a surface; a continuous or discontinuous terbium(III)-triphenylphosphine oxide coordination polymer layer deposited on the surface, wherein the polymer layer is porous; and a luminescence detector, wherein one or more analytes that interact with the polymer layer luminesce at distinct wavelengths unique to each analyte.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 25, 2014
    Inventors: Simon M. Humphrey, Bradley J. Holliday
  • Publication number: 20140273258
    Abstract: A functional element positioned in front of an active detection region of a sensor element has a compact main body with a gas-side surface, a sensor-side surface, and at least two functional channels located between the gas-side surface and the sensor-side surface. The functional channels have a functionality that is different from one another with respect to a gas that can pass through. Such a functional element allows particularly variable operation of a sensor with great long-term stability.
    Type: Application
    Filed: March 5, 2014
    Publication date: September 18, 2014
    Applicant: Robert Bosch GmbH
    Inventors: Richard Fix, Andreas Krauss
  • Publication number: 20140256053
    Abstract: A reversible color-changing ink formulation, and a nonwoven wipe to which the ink formulation is securely bound, are provided. The reversible color-changing ink formulation includes about 55-98% by weight of a polymer binder, about 0.1-20% by weight of a reversible color-changing dye that reversibly changes between a first color and a second color at a pH of about 5.5 to about 8.0, and optional amounts of plasticizer, inorganic particulate filler, and color brightener. During use, the nonwoven wipe is impregnated with a sanitizer solution that contains a quaternary ammonium compound. The nonwoven wipe reversibly changes between a first color when impregnated with the sanitizer solution and a second color when the sanitizer solution is depleted during use. The change to the second color indicates the need to recharge the nonwoven wipe with the sanitizer solution, whereupon the first color returns.
    Type: Application
    Filed: May 22, 2014
    Publication date: September 11, 2014
    Applicant: Illinois Tool Works Inc.
    Inventors: Paul Richard Jelonek, Ernani Bernardo
  • Patent number: 8828728
    Abstract: An aquatic environment monitoring system and method that includes correction for adverse conditions in the monitoring system involving the development of confidence levels for certain conditions in the monitoring system using stored information related to the aquatic environment and/or the monitoring system. Corrections to adverse conditions may be made by the environment monitoring system automatically by the monitoring system and manually via communications to a user of the system.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: September 9, 2014
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark
  • Patent number: 8815604
    Abstract: A microchannel chip having a microchannel formed in a substrate and a gas-liquid phase separation microchannel whose upper part is covered with a porous film, the gas-liquid phase separation microchannel being connected to the downstream end of the microchannel and having a depth of 10 ?m to 100 ?m. Also, a gas-liquid phase separation method which is a method for separating a liquid-phase flow from a two-phase flow flowing through a microchannel by removing a gas phase, the two-phase flow composed of the gas phase and the liquid phase, which liquid phase flows in the periphery of the above-described microchannel and which gas phase flows interiorly of the liquid-phase flow.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: August 26, 2014
    Assignees: Institute of Microchemical Technology Co., Ltd., The University of Tokyo, Kanagawa Academy of Science and Technology
    Inventors: Arata Aota, Yuko Kihira, Mari Sasaki, Takehiko Kitamori, Kazuma Mawatari
  • Patent number: 8809063
    Abstract: A fluorescence based sensor (10) is disclosed and described. The sensor (10) can include nanofibril materials (12) fabricated from a linear carbazole oligomer and a fluorescence detector (14). The linear carbazole oligomer can have the formula (I) wherein n is 3 to 9, R are independently selected amine sidegroups, and at least one, but not all, R is a C1 to C14 alkyl. The carbazole-based fluorescence based sensors (10) can be particularly suitable for detection of explosives and volatile nitro compounds.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: August 19, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Ling Zang, Yanke Che
  • Publication number: 20140228391
    Abstract: An anise flavored liquid medication. The liquid medication contains phenylephrine and an anethole analog that is substantially free of aldehyde groups. In one example, the anethole analog can be 1-methoxy-4-n-propylbenzene.
    Type: Application
    Filed: February 13, 2014
    Publication date: August 14, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Allyn Michael Kaufmann, James Carl Grimm, Chelsay Lynn Brewster, Thomas Edward Huetter
  • Publication number: 20140206095
    Abstract: Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula where R1-R4 independently are hydrogen hydroxyl, halogen, thiol, thioether, lower aliphatic, or lower alkoxy, x is an integer from 0 to 4, and each R5 independently is halogen, hydroxyl, thiol, thioether, lower aliphatic, or lower alkoxy. Embodiments of the disclosed probes are capable of undergoing condensation/cyclization reactions with cysteine and/or homocysteine. Cysteine and/or homocysteine can be selectively detected and identified by determining fluorescence emission of the probes at characteristic wavelengths.
    Type: Application
    Filed: August 2, 2012
    Publication date: July 24, 2014
    Applicant: State of Oregon Acting by and through the State Board of Higher Education on behalf of Portland st
    Inventors: Robert Strongin, Xiaofeng Yang
  • Patent number: 8785204
    Abstract: The invention provides a method of assaying for tetrahydrocannabinol in a body fluid. The method includes contacting a sample of body fluid with an imine capable of reacting with tetrahydrocannabinol to yield a quinone imine, and detecting the formation of a quinone imine, where the sample is contacted with the reagent compound at a pH of at least 10.5.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: July 22, 2014
    Assignee: Oxtox Limited
    Inventors: Dimitrios Konstantinos Kampouris, Patrick Robinson Huddleston, Craig Edward Banks
  • Patent number: 8778690
    Abstract: The invention provides a porous sensor and sensing methods that use a porous sensor with a porous nanostructure having an optical response and having a portion of the porous nanostructure filled with a fiducial marker that is non-reactive to an analyte of interest. In a preferred sensing method, reflectance spectra from both the fiducial marker and reactive portions of the porous structure are acquired simultaneously. The fiducial marker provides an internal reference that permits compensation for humidity, as well as off angle measurements. In addition, simple visual observations can reveal the presence of an analyte, including human observations.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: July 15, 2014
    Assignee: The Regents of the University of California
    Inventors: Michael J. Sailor, Anne M. Ruminski
  • Publication number: 20140178358
    Abstract: The present invention concerns means and methods for predicting the risk of a subject to suffer from liver damage. In particular, it pertains to a method for predicting the risk of a subject to suffer from liver damage caused by acetaminophen comprising determining the amount of putrescine in a blood, serum or plasma sample that has been obtained from the subject after administration of acetaminophen, and comparing the determined amount to a reference, whereby the risk of the subject to suffer from liver damage caused by acetaminophen is predicted. Also provided are devices for carrying out the aforementioned methods.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 26, 2014
    Applicants: The United States of America as represented by the Secretary of Department of Health and Human Servi, Metanomics Health GmbH
    Inventors: Alexander Strigun, Lisette Leonhardt, Dörthe Ahlbory-Dieker, Lisa M. Pence, Richard Beger
  • Patent number: 8735057
    Abstract: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: May 27, 2014
    Assignee: The Regents of the University of California
    Inventor: Rebecca Braslau
  • Publication number: 20140127824
    Abstract: A method for the detection of explosives using a single sample. The explosives include nitro aliphatic and nitro aromatic-based explosives. The method includes steps which require different pHs to discriminate between these types of explosives and at least in the detection step of the nitro aliphatic explosive requires the presence of a nitro aromatic compound. A kit for detecting explosives which includes a medium for collecting a sample, a base optionally impregnated on the medium; and a nitro aromatic solution for detecting a nitro aliphatic explosive by contacting the solution with the sample on the medium. A reagent including a nitro aromatic compound, having one or more additional electron withdrawing groups, in the presence of a basic compound usable for detecting nitro aliphatic explosives.
    Type: Application
    Filed: June 27, 2012
    Publication date: May 8, 2014
    Applicant: MISTRAL DETECTION LTD.
    Inventor: Shai Amisar
  • Publication number: 20140127822
    Abstract: One aspect of the invention relates to an ultrathin micro-electromechanical chemical sensing device which uses swelling or straining of a reactive organic material for sensing. In certain embodiments, the device comprises a contact on-off switch chemical sensor. For example, the device can comprises a small gap separating two electrodes, wherein the gap can be closed as a result of the swelling or stressing of an organic polymer coating on one or both sides of the gap. In certain embodiments, the swelling or stressing is due to the organic polymer reacting with a target analyte.
    Type: Application
    Filed: May 14, 2013
    Publication date: May 8, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: William Jay Arora, Karen K. Gleason, George Barbastathis, Wyatt E. Tenhaeff
  • Patent number: 8709819
    Abstract: A preparation method and its use of derivatization reagent for detecting L-carnitine or D-carnitine are provided. The present reagent is stable. It can be used for detecting L-carnitine or D-carnitine accurately and sensitively. That is to say, the reagent is applied to detecting the amount of synthesized or natural L-carnitine and the amount of mixing D-carnitine. The compound reagent is used for determining the chiral isomers of chemicals, biological reagents, health care reagents, cosmetic, body fluids and various foods, which contain L-carnitine or/and D-carnitine, and optical isomers of other chiral amino acids.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: April 29, 2014
    Inventors: Shuhua Gu, Qingyi Li, Xuecheng Wang
  • Patent number: 8703500
    Abstract: A chemical sensor can include a nanofiber mass of p-type nanofibers having a HOMO level greater than ?5.0 eV. Additionally, the chemical sensor can include oxygen in contact with the p-type nanofibers. Further, the chemical sensor can include a pair of electrodes in electrical contact across the nanofiber mass, where the p-type nanofibers conduct an electric current that decreases upon contact with an amine compound.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: April 22, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Ling Zang, Yanke Che
  • Publication number: 20140106463
    Abstract: The present invention provides methods for determining the presence of oxidizing salts. According to the current invention, analyte is collected on a swipe and subsequently heated to a temperature sufficient to release a detectible vapor phase component of the oxidizing salt. The vapor phase component passes reacts with a pH sensitive molecule. Reaction of the vapor phase product with the pH sensitive molecule produces a detectible change in response intensity.
    Type: Application
    Filed: October 12, 2012
    Publication date: April 17, 2014
    Inventors: Lara Beth Wald, Gregory Charles Frye-Mason
  • Publication number: 20140093970
    Abstract: A method for determining whether a subject has alcoholic hepatitis is described. The method includes determining the levels of a trimethylamine in a biological sample obtained from the subject. The level of trimethylamine in the biological sample is compared to the control value, and the subject whose level of trimethylamine exceeds the control value is diagnosed as having alcoholic hepatitis.
    Type: Application
    Filed: September 30, 2013
    Publication date: April 3, 2014
    Applicant: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Raed Dweik, Ibrahim Hanouneh, Nizar Zein, David Grove, Frank S. Cikach, JR.
  • Patent number: 8685739
    Abstract: There is provided a method of diagnosing a disease state in a subject. The disease state is caused or effected by pneumococcal infection. The method includes obtaining a biological test sample from the subject. The biological sample includes at least one metabolite selected from the group consisting of citrate, trigonelline, acetylcarnitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine. A respective concentration of each one of the at least one metabolite is compared with a predetermined concentration value associated with a corresponding one of the at least one metabolite. The predetermined concentration value is indicative of the disease state. For example, the biological sample includes any one of citrate, trigonelline, acetylcamitine, acetone, myoinositol, 3-hydroxybutyrate, glucose and carnitine. As a further example, the biological samples include any combination of citrate, trigonelline, acetylcamitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: April 1, 2014
    Inventors: Carolyn Slupsky, Thomas Marrie
  • Patent number: 8668874
    Abstract: A gas-phase detection system based on detecting optochemical and optoelectrochemical signals. The sensing platform is particularly powerful for detection of nitrogen oxides at low ppbV concentrations. The optochemical analysis is based on the color development due to a chemical reaction taking place in an optimized material. The electrochemical analysis can be based on the doping level or redox potential changes of an electrochemical sensor; and optoelectrochemical detection can be based on a combination of the electrochemical and optoelectrochemical methodologies. Each independent signal can be simultaneously detected, increasing the reliability of detection.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: March 11, 2014
    Assignee: Arizona Board of Regents for and on Behalf of Arizona State University
    Inventors: Nongjian Tao, Erica Forzani, Rodrigo A Iglesias
  • Patent number: 8663995
    Abstract: There are provided a method for analyzing an aqueous ammonium carbamate solution whereby the composition of an unreacted-gas absorber outlet liquid can be specified in real time, and a method for operating an unreacted gas absorber by use of the same.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: March 4, 2014
    Assignee: Toyo Engineering Corporation
    Inventors: Eiji Sakata, Kenji Yoshimoto, Shuhei Nakamura