Tertiary Amine Patents (Class 436/112)
  • Patent number: 5521060
    Abstract: A sparingly soluble salt of a heteropoly acid is used for the determination of an analyte which is an aromatic amine rich in electrons or together with another substance leads to such an amine. The analyte is determined by means of the heteropoly blue color formed.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: May 28, 1996
    Assignee: Boehringer Mannheim GmbH
    Inventors: Joachim Hoenes, Hans Wielinger, Volker Unkrig
  • Patent number: 5480807
    Abstract: The present invention is directed to use of an imidazo [4,5b] pyridinium molecule composed of a lysine and an arginine residue crosslinked with a pentose sugar for assessing the biological age of a tissue.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: January 2, 1996
    Assignee: Case Western Reserve University
    Inventors: Vincent M. Monnier, David R. Sell
  • Patent number: 5445943
    Abstract: The invention concerns a method for the colorimetric determination of NADH by means of enzymatic oxidation with benzyl alcohol dehydrogenase whereby an aromatic nitrosoaniline compound of the general formula I is reduced to a colored quinone diimine ##STR1## in which R.sup.1 denotes hydrogen, halogen, hydroxy, alkoxy, aryloxy, alkylthio, arylthio, alkyl or alkylene substituted if desired by carboxy, PO.sub.3 H.sub.2, dialkylphosphinyl or SO.sub.3 H, amino substituted if desired once or twice by alkyl which in turn can be substituted if desired by hydroxy, PO.sub.3 H.sub.2, SO.sub.3 H or carboxy and R denotes a residue which forms a color by electron conjugation with a quinone diimiine system. The invention also concerns a corresponding agent as well as a chromogenic nitroso compound of formula I as well as its use for the enzymatic colorimetric determination of an analyte.
    Type: Grant
    Filed: April 8, 1994
    Date of Patent: August 29, 1995
    Assignee: Boehringer Mannheim GmbH
    Inventor: Joachim Hoenes
  • Patent number: 5401662
    Abstract: In the method for the determination of water, the sample is admixed with a molar 1:1 adduct of sulphur dioxide with an amine having a pK.sub.A of more than 6, dissolved in an aprotic solvent, and is oxidized with iodine.
    Type: Grant
    Filed: September 13, 1993
    Date of Patent: March 28, 1995
    Assignee: Riedel-de Haen Aktiengesellschaft
    Inventors: Hermann Matschiner, Claus-Peter Maschmeier
  • Patent number: 5382523
    Abstract: A sparingly soluble salt of a heteropoly acid is used for the determination of an analyte which is an aromatic amine rich in electrons or together with another substance leads to such an amine. The analyte is determined by means of the heteropoly blue color formed.
    Type: Grant
    Filed: April 13, 1993
    Date of Patent: January 17, 1995
    Assignee: Boehringer Mannheim GmbH
    Inventors: Joachim Hoenes, Hans Wielinger, Volker Unkrig
  • Patent number: 5281517
    Abstract: A method and apparatus are provided for selecting and analyzing a subpopulation of cells or cell objects for a certain parameter such as DNA using image analysis means. The cells are first stained with an alkaline phosphatase technique including a monoclonal antibody specific to a protein in at least one of the cell's cytoplasm or on a cell membrane, thereby marking any cells including the protein as to type. A second staining of the DNA in the nucleus is accomplished by a Feulgen technique that destroys the cell cytoplasm. After the staining and marking, the cells may then be gated using the image analysis means on the visual parameter such as colored DNA or colored antigen into a subpopulation that is to be measured. The selected cells may then be examined by digital image processing and measured for a parameter such as a true actual measurement of DNA in picograms. A quantitation of the measured parameter may be generated and provided.
    Type: Grant
    Filed: February 5, 1992
    Date of Patent: January 25, 1994
    Assignee: Cell Analysis Systems, Inc.
    Inventors: James W. Bacus, Robert J. Marder
  • Patent number: 5264622
    Abstract: Novel water-soluble methylenebis(dialkylaniline) derivatives of the following general formula and salts thereof are disclosed. They are useful as dye-forming substances in quantitative determination of peroxides in the copresence of peroxidase or the like. ##STR1## In the formula, R.sub.1 is hydrogen or a substituent selected from lower alkyl and C.sub.2-3 sulfoalkyl or hydroxysulfoalkyl; R.sub.2 is C.sub.2-3 sulfoalkyl or hydroxysulfoalkyl; and R.sub.3 is lower alkyl.
    Type: Grant
    Filed: December 21, 1992
    Date of Patent: November 23, 1993
    Assignee: Dojindo Laboratories
    Inventor: Makoto Mizoguchi
  • Patent number: 5240860
    Abstract: A sparingly soluble salt of a heteropoly acid is used for the determination of an analyte which is an aromatic amine rich in electrons or together with another substance leads to such an amine. The analyte is determined by means of the heteropoly blue color formed.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: August 31, 1993
    Assignee: Boehringer Mannehim GmbH
    Inventors: Joachim Hoenes, Hans Wielinger, Volker Unkrig
  • Patent number: 5221627
    Abstract: A method of detection of amino acids comprising the application, to the material being tested, of a reagent comprising the following basic formula: ##STR1## where X, Y and/or Z may be nitrogen C--H, C-alkyl or C-aryl and wherein A, B, C and/or D may be an alkyl or aryl substituent either alone or in combination.
    Type: Grant
    Filed: May 24, 1991
    Date of Patent: June 22, 1993
    Assignee: The Queen's University of Belfast
    Inventors: Ronald E. Grigg, Charles A. Pounds, Teirevat Mongkolaussavaratana
  • Patent number: 4908322
    Abstract: Primary and secondary amines in biological fluids are selectively derivitized by reaction with esters of N-hydroxysuccinimide or N-hydroxysulfosuccinimide to form an N-acylated derivative. Those N-acylated derivatives may then be extracted into a polar organic phase and extracted. Non-electroactive amines may be made suitable for coulometric analysis by selecting the ester used so as to attach an electroactive group to the amine. For example, histamine may be reacted with the Bolton-Hunter reagent to form a suitable derivative in high yield.
    Type: Grant
    Filed: December 27, 1988
    Date of Patent: March 13, 1990
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Kenneth A. Jacobson, Kenneth L. Kirk, Markku I. Linnoila, Thomas Miller, Kazunori Mine
  • Patent number: 4902627
    Abstract: A method of analyzing a sample for selected molecules which consists of reacting the molecule with a reagent that produces a charged derivative which can be desorbed and analyzed using Secondary Ion Mass Spectrometry (SIMS).
    Type: Grant
    Filed: February 5, 1985
    Date of Patent: February 20, 1990
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: David Kidwell
  • Patent number: 4900681
    Abstract: A solution of various benzaldehyde derivatives dissolved in suitable solvents are used in impinger sampling or as a coating on substrates to provide passive, real-time visual colorimetric indication of the presence of hydrazine and its derivatives.
    Type: Grant
    Filed: June 2, 1988
    Date of Patent: February 13, 1990
    Inventors: Patricia A. Taffe, Susan L. Rose-Pehrsson
  • Patent number: 4840919
    Abstract: A gas dosimeter utilizing a colorimetric reagent for the selective determination of total amines in solution or in air is described. The reagent comprises 1,2 napthoquinone-4-sulfonic acid or a derivative thereof. Upon addition of amines, a color is formed which is quantitatively related to the number of amine molecules reacted. The reagent can be utilized to detect aromatic amines apart from primary amines by the addition of a buffering agent to maintain the pH less than 4.5.
    Type: Grant
    Filed: March 3, 1987
    Date of Patent: June 20, 1989
    Assignee: Perfect View, Inc.
    Inventor: Amir J. Attar
  • Patent number: 4421858
    Abstract: The present invention describes a method where, by using gentian violet as a tracer substance, the concentration of one or more selected components or factors of a complete animal feedstuff may be monitored throughout the life of the feed whether at the mill, in transit or at the place of its end use. In one embodiment, the method may be used to determine quickly whether any separation of components has occurred thereby destroying the homogeneity of the feedstuff and potentially endangering the animals to which the feedstuff is provided.
    Type: Grant
    Filed: July 10, 1981
    Date of Patent: December 20, 1983
    Assignee: Cambridge Products, Ltd.
    Inventor: Dennis E. Jackson
  • Patent number: 4375466
    Abstract: A method of determining affective illness (i.e. mood disorders) involves serological testing. The serotonin uptake of the patient's blood platelets is determined and compared with a standard blood platelet serotonin uptake characteristic of a particular type of affective illness to determine the patient's type of affective illness. A method of treating a patient having a particular affective illness is provided which includes treating the patient with an effective amount of at least one drug which is effective in treating persons having the same blood platelet serotonin uptake as the patient.
    Type: Grant
    Filed: April 14, 1980
    Date of Patent: March 1, 1983
    Inventor: Janet Leuschner