Spectrum Analysis (e.g., Flame Photometry, Etc.) Patents (Class 436/171)
  • Patent number: 11959061
    Abstract: An apparatus for electroporation of biological cells is provided. The apparatus includes a sample container having an insulator chamber for holding the cells. The sample container has a first electrode and a second electrode to provide electrical connection for electroporation. The insulator chamber is configured to contain at least one cell monolayer. The apparatus also includes a pulse generator that can generate a predetermined pulse for electroporation of the cells.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: April 16, 2024
    Inventor: Jian Chen
  • Patent number: 11959858
    Abstract: Chronic Kidney Disease (CKD) is characterized by the progressive loss of renal function which eventually leads to End Stage Renal Disease (ESRD). CKD affects roughly 30 million Americans, costs billions of dollars in healthcare spending annually, and leaves thousands of patients reliant on burdensome dialysis treatments while waiting for a transplant. Fortunately, CKD may be controllable if diagnosed early in the disease progression. RAMETRIX™ is a novel public health screening technology for early diagnosis and detection of CKD. This technology uses Raman spectroscopy and chemometrics to analyze the molecular composition of urine and other biological fluids. RAMETRIX™ is a fast, non-invasive, accurate, and inexpensive diagnostic tool that can revolutionize the way healthcare providers detect and treat CKD. The RAMETRIX™ AutoScanner is a system enabling more efficient sample processing in large-scale settings such as hospitals and medical laboratories.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: April 16, 2024
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: John L. Robertson, Ryan Senger
  • Patent number: 11907331
    Abstract: Disclosed in the present invention are a method and system for evaluating a fractal dimension of particle matter in a dispersing system. The method includes: setting that distribution of a particle radius r of particle matter in a dispersing system obeys logarithmic normal distribution lnr˜N(?, ?2) with an expectation ? and a standard deviation ?, and determining the value of the standard deviation ?; and evaluating a fractal dimension Dƒ of the dispersing system on the basis of the standard deviation ?, an evaluation formula being: Dƒ=1/?. The present invention provides the formula for evaluating the fractal dimension of particle distribution in a dispersing system. When the formula is used to calculate a fractal dimension, only particle radius distribution of particle matter needs to be measured, and no geometrical morphology feature parameter of the particle matter needs to be measured. Factors such as particle morphology and the like do not affect the fractal dimension.
    Type: Grant
    Filed: October 9, 2023
    Date of Patent: February 20, 2024
    Assignee: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Mingliang Xie, Yixiong Yang, Zhihao Jiang
  • Patent number: 11852575
    Abstract: A state determination apparatus includes: electrodes configured to apply AC signal to a mixture; a measurement unit configured to measure an impedance of the mixture for every frequency of the AC signal based on a response signal flowing through the mixture when the AC signal is applied; a setting unit configured to set an equivalent circuit including one or a plurality of parallel circuit(s) based on element(s) corresponding to electrical component(s) of a solid matter; a calculating unit configured to calculate a parameter of the parallel circuit by executing an equivalent circuit analysis for approximating impedance of the equivalent circuit to the impedance of the mixture; and a derivation unit configured to derive an index for specifying a state of the mixture based on the parameter of the parallel circuit.
    Type: Grant
    Filed: August 4, 2021
    Date of Patent: December 26, 2023
    Assignee: HIOKI E.E. CORPORATION
    Inventors: Yuki Kawamuro, Akihiro Shioiri, Naoto Nakayama
  • Patent number: 11827533
    Abstract: A method of determining a disinfectant composition of a municipal water supply from a water sample that includes: (a) obtaining a water sample from a water source at a sampling location; (b) adding a chlorine-containing material to the water sample in the presence of an oxidation reduction potential (ORP) measurement device; (c) generating a plurality of ORP measurements during addition of the chlorine-containing material to the water sample; (d) estimating a concentration of one or more of free ammonia, fully combined ammonia, monochloramine, or a mixture of dichloroamine and trichloroamine in the water sample in which the estimation is derived from the relationship between the added chlorine material and the plurality of ORP measurements; and (e) determining a disinfectant composition of the water source at the water sampling location from the concentration calculation. A method of determining free ammonia composition is also included.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: November 28, 2023
    Assignee: UGSI Solutions, Inc.
    Inventors: Robin Giguere, Peter Fiske
  • Patent number: 11808710
    Abstract: Disclosed herein are methods for measuring the ionic strengths of the natural water sources. Also disclosed herein are systems used to measure an ionic strength of the natural water sources. More specifically disclosed herein are methods and systems utilizing spectroscopic pH measurements and calculations of the ionic strength as a function of the measured pH.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: November 7, 2023
    Assignee: University of South Florida
    Inventor: Robert H. Byrne
  • Patent number: 11802865
    Abstract: A method of analyzing a polymer resin comprising: providing a polymer resin sample having two or more polymer components; subjecting the sample to aTREF analysis to yield aTREF elution trace by contacting the sample with aTREF solvent to form sample solution; introducing sample solution into aTREF column and allowing elution of polymer components at different elution rates along the column; eluting from the aTREF column an aTREF eluent comprising the polymer components eluting at different rates; and subjecting the aTREF eluent to IR detection to yield the aTREF elution trace; identifying the components of the sample to yield identified components by comparing the elution trace with an identification library that comprises a plurality of known polymer aTREF elution traces correlated with known polymer components characterized by identifying parameters (density, SCB, crystallization temperature, MI, HLMI, MWD); and quantifying each of the identified components to yield quantified polymer components via chemome
    Type: Grant
    Filed: December 27, 2021
    Date of Patent: October 31, 2023
    Assignee: Chevron Phillips Chemical Company LP
    Inventors: JaNeille K. Dixon, Todd A. Robinson, James A. Solis, Justin W. Kamplain
  • Patent number: 11768362
    Abstract: A laser radiation system according to a viewpoint of the present disclosure includes a first optical system configured to convert a first laser flux into a second laser flux, a multimirror device including mirrors, configured to be capable of controlling the angle of the attitude of each of the mirrors, and configured to divide the second laser flux into laser fluxes and reflect the laser fluxes in directions to produce the divided laser fluxes, a Fourier transform optical system configured to focus the divided laser fluxes, and a control section configured to control the angle of the attitude of each of the mirrors in such a way that the Fourier transform optical system superimposes the laser fluxes, which are divided by the mirrors separate from each other by at least a spatial coherence length of the second laser flux, on one another.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: September 26, 2023
    Assignee: Gigaphoton Inc.
    Inventors: Akiyoshi Suzuki, Osamu Wakabayashi
  • Patent number: 11719632
    Abstract: Disclosed is a localised surface plasmon resonance (LSPR) nanopillar assembly. The LSPR assembly is for use in sensing the presence of a biomarker when attached to a quantum dot. The LSPR assembly comprises a substrate and an array. The array comprises a LSPR nanopillar and a polymer spacer attached to the nanopillar. The LSPR assembly further comprises an antibody attached to the at least one polymer spacer. In the LSPR assembly, a combined height of the polymer spacer and antibody is selected by varying the number of monomer units of the polymer spacer, so that, when in use with the biomarker and the quantum dot, the quantum dot is at a predetermined distance from the nanopillar.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: August 8, 2023
    Assignees: Temasek Polytechnic, Agency for Science, Technology and Research, Tan Tock Seng Hospital Pte. Ltd.
    Inventors: Ling Ling Sun, Willie Ng, Xiaodong Zhou, Ten It Wong, Yee Sin Leo
  • Patent number: 11642023
    Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: May 9, 2023
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Robert Vince, Swati Sudhakar More
  • Patent number: 11621059
    Abstract: A method is provided for predicting conjunct polymer concentration in spent ionic liquid during a continuous hydrocarbon conversion process.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: April 4, 2023
    Assignee: CHEVRON U.S.A. INC.
    Inventors: Toni Zhang Miao, Huping Luo, Hye-Kyung Cho Timken, Eddy Lee, Bong-Kyu Chang
  • Patent number: 11541658
    Abstract: One example provides a fluidic die including a semiconductor substrate, and a nozzle layer disposed on the substrate, the nozzle layer having a top surface opposite the substrate and including a nozzle formed therein, the nozzle including a fluid chamber disposed below the top surface and a nozzle orifice extending through the nozzle layer from the top surface to the fluid chamber, the fluid chamber to hold fluid, and the nozzle to eject fluid drops from the fluid chamber via the nozzle orifice. An electrode is disposed in contact with the nozzle layer about a perimeter of the nozzle orifice, the electrode to carry an electrical charge to adjust movement of electrically charged components of the fluid.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: January 3, 2023
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Daryl E. Anderson, Eric Martin, James R. Przybyla, Chien-Hua Chen
  • Patent number: 11536739
    Abstract: Example automated diagnostic analyzers and methods for using the same are disclosed herein. An example apparatus described herein includes a first carousel rotatably coupled to a base and having a first axis of rotation. The example apparatus includes a second carousel rotatably coupled to the base and vertically spaced over the first carousel such that at least a portion of the second carousel is disposed over the first carousel. In the example apparatus, the second carousel has a second axis of rotation and a plurality of vessels. The example apparatus also includes a pipetting mechanism offset from the second axis of rotation. The example pipetting mechanism is to access the first carousel and the second carousel.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: December 27, 2022
    Assignee: Abbott Laboratories
    Inventors: Brian L. Ochranek, David C. Arnquist, Takehiko Oonuma, Hirotoshi Tahara, Naoto Sato
  • Patent number: 11525772
    Abstract: A method comprises: aspirating a sample through a needle capillary into a chamber having first and second windows, the capillary and chamber both affixed to a moveable robotic arm; causing a light beam generated by a light source that is affixed to the robotic arm to pass through the sample between the windows; detecting, using a photodetector that is affixed to the robotic arm, a quantity of the light that passes through the sample and the windows; determining an optical absorbance of the sample and a concentration of an analyte in the sample from the detected quantity of light; determining a quantity of the sample to dispense into an analytical apparatus based on the determined concentration; moving the robotic arm so as to cause the needle capillary to mate with an inlet port of an analytical apparatus; and dispensing the determined quantity of the sample into the analytical apparatus.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: December 13, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Greg A. Foster, Daniel Lopez Ferrer
  • Patent number: 11275072
    Abstract: Effects of Oxygen on grease or another organic paste product can be evaluated with a modified version of the ASTM D942 test methodology for oxidation stability of lubricating greases or other organic paste products by employment of an oxidation pressure vessel, in which at least one of (A) a very small sample of the grease or other organic paste product is deployed for testing within the oxidation pressure vessel such that the sample has an enhanced surface area to mass ratio, and (B) a temperature other than about 99° C. is employed during the testing. In general, the testing is carried out under oxidation pressure conditions. The sample may be evaluated with respect to Oxygen uptake. Additional technique(s) directed to oxidation and/or other properties of the sample may be carried out before to after any Oxygen uptake evaluation, for example, FTIR analysis and/or ATR-FTIR analysis.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: March 15, 2022
    Assignee: TANNAS COMPANY
    Inventors: Jonathan C. Evans, Theodore W. Selby, Marta Manning
  • Patent number: 11113627
    Abstract: Machine learning is performed on input data representing a dynamical statistical system of entities having plural primary variables that vary time. A distribution function over time of the density of entities in a phase space, whose dimensions are the primary variables and secondary variables dependent on the rate of change of the primary variables, is derived and encoded as a sum of contour functions over time describing the contour in phase space of plural phaseons which are entities of a model of the dynamical statistical system that are localised in the phase space. Machine learning is performed on the encoded distribution function and/or at least one field in the effective configuration space whose dimensions are the primary variables, derived from the encoded distribution function. The encoding of the distribution function provides a representation which improves the performance of the machine learning techniques by simplifying hyperparameter optimisation.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: September 7, 2021
    Assignee: NOBLE ARTIFICIAL INTELLIGENCE, INC.
    Inventor: Matthew Chase Levy
  • Patent number: 10962473
    Abstract: An artificial intelligence model receives a FTIR spectrum of a given ingredient to predict its protein secondary structure. The model includes three artificial modules, which generate three predicted values corresponding to structural categories (e.g., ?-helix, ?-sheet, and other) of the predicted secondary structure. Proteins may be compared for similarity based on predicted values corresponding to the structural categories of the predicted secondary structure.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: March 30, 2021
    Assignee: NOTCO DELAWARE, LLC
    Inventors: Nathan O'Hara, Adil Yusuf, Julia Christin Berning, Francisca Villanueva, Rodrigo Contreras, Isadora Nun, Aadit Patel, Karim Pichara
  • Patent number: 10739310
    Abstract: Embodiments relate generally to an ultraviolet lamp (100) for use with a photoionization detector comprising a sealed tube (102) configured to contain at least one gas; a coating (120) applied to the inner surface (110) of the sealed tube (102); and a crystal window (112) attached to the sealed tube (102), configured to allow transmittance of ultraviolet (UV) light generated within the sealed tube (102).
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: August 11, 2020
    Assignee: Honeywell International Inc.
    Inventors: Aimin Su, Zhongxing Cao, Bing Chen, Feng Liang
  • Patent number: 10705050
    Abstract: Embodiments relate generally to an ultraviolet lamp (100) for use with a photoionization detector comprising a sealed tube (102) configured to contain at least one gas; a coating (120) applied to the inner surface (110) of the sealed tube (102); and a crystal window (112) attached to the sealed tube (102), configured to allow transmittance of ultraviolet (UV) light generated within the sealed tube (102).
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: July 7, 2020
    Assignee: Honeywell International Inc.
    Inventors: Aimin Su, Zhongxing Cao, Bing Chen, Feng Liang
  • Patent number: 10605842
    Abstract: A method for analyzing noise spectrum of an electronic device includes storing a waveform data including a plurality of data points, the waveform data is obtained by measuring a target signal from the electronic device, removing data points corresponding to a background noise fluctuation based on a smooth curve of the waveform data, data points considered candidates for peaks are extracted from the waveform data, classifying the extracted data points based on a distance between adjacent data points in order to discriminate a cluster of distant data points from data points closely positioned to dominant peaks, determining the dominant peaks based on the cluster of distant data points such that the data points closely positioned to the dominant peaks are ignored, each dominant peak corresponds to the characteristic of the electronic device, and outputting the dominant peaks as an analysis result for the electronic device.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: March 31, 2020
    Assignee: International Business Machines Corporation
    Inventors: Shinichi Ikami, Lijie Qiao
  • Patent number: 10585130
    Abstract: A method for analyzing noise spectrum of an electronic device includes storing a waveform data including a plurality of data points, the waveform data is obtained by measuring a target signal from the electronic device, removing data points corresponding to a background noise fluctuation based on a smooth curve of the waveform data, data points considered candidates for peaks are extracted from the waveform data, classifying the extracted data points based on a distance between adjacent data points in order to discriminate a cluster of distant data points from data points closely positioned to dominant peaks, determining the dominant peaks based on the cluster of distant data points such that the data points closely positioned to the dominant peaks are ignored, each dominant peak corresponds to the characteristic of the electronic device, and outputting the dominant peaks as an analysis result for the electronic device.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: March 10, 2020
    Assignee: International Business Machines Corporation
    Inventors: Shinichi Ikami, Lijie Qiao
  • Patent number: 10274424
    Abstract: The present invention provides a Voigt line shape fitting method, including step 1: Calculate a Gauss line shape function and a Lorentz line shape function, and calculate a Voigt line shape function. Step 2: For determined line shape parameters to be fitted, calculate partial derivatives of the Voigt line shape function with respect to the parameters, convert a partial derivative of the Voigt line shape function with respect to a parameter into a partial derivative of the Gauss line shape function or the Lorentz line shape function with respect to the parameter. Step 3: Substitute the Voigt line shape function and the partial derivative of the Voigt line shape function with respect to the parameter to be fitted, into a least squares algorithm step, perform least squares fitting calculation, and determine whether to terminate the least squares fitting calculation or return to step 1 to perform next iterative calculation.
    Type: Grant
    Filed: April 21, 2018
    Date of Patent: April 30, 2019
    Assignee: Space Engineering University
    Inventors: Wei Rao, Guangyu Wang, Yanji Hong, Junling Song
  • Patent number: 10240749
    Abstract: The Invention provides a light source, a luminaire and a surgical illumination unit in which two narrow-band light emitters both emit light in a narrow spectral peak having a full-width-half-maximum equal to or smaller than 40 nanometers. Both of the narrow-band light emitters have a different central emission wavelength within a blue color-range, within a green color range or within a red color-range. At least one of the two narrow-band light emitters comprises a luminescent material for generating the narrow spectral peak. The light source is further configured such that a distance between the narrow spectral peaks of the two narrow-band light emitters prevents overlap of the narrow spectral peaks. Due to the individual narrow spectral peaks, a color contrast within one of the color-ranges is significantly enhanced.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: March 26, 2019
    Assignee: PHILIPS LIGHTING HOLDING B.V.
    Inventors: Ties Van Bommel, Rifat Ata Mustafa Hikmet
  • Patent number: 10234382
    Abstract: A method and kit are provided for diagnosing and monitoring the progress of COPD using FTIR spectral analysis of sputum samples where spectral data is obtained and used to monitor the progression of the disease over time.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: March 19, 2019
    Assignee: PULMONIR LIMITED
    Inventor: Paul Lewis
  • Patent number: 10156479
    Abstract: Systems, methods and other embodiments associated with spatial-domain Low-coherence Quantitative Phase Microscopy (SL-QPM) are described herein. SL-QPM can detect structural alterations within cell nuclei with nanoscale sensitivity (0.9 nm) (or nuclear nano-morphology) for “nano-pathological diagnosis” of cancer. SL-QPM uses original, unmodified cytology and histology specimens prepared with standard clinical protocols and stains. SL-QPM can easily integrate in existing clinical pathology laboratories. Results quantified the spatial distribution of optical path length or refractive index in individual nuclei with nanoscale sensitivity, which could be applied to studying nuclear nano-morphology as cancer progresses. The nuclear nano-morphology derived from SL-QPM offers significant diagnostic value in clinical care and subcellular mechanistic insights for basic and translational research. Techniques that provide for depth selective investigation of nuclear and other cellular features are disclosed.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: December 18, 2018
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Yang Liu, Randall E. Brand, Hoa V. Pham, Shikhar Fnu
  • Patent number: 9964632
    Abstract: A light detection and ranging (LIDAR) system can emit light toward an environment and detect responsively reflected light to determine a distance to one or more points in the environment. The reflected light can be detected by a plurality of plurality of photodiodes that are reverse-biased using a high voltage. Signals from the plurality of reverse-biased photodiodes can be amplified by respective transistors and applied to an analog-to-digital converter (ADC). The signal from a particular photodiode can be applied to the ADC by biasing a respective transistor corresponding to the particular photodiode while not biasing transistors corresponding to other photodiodes. The gain of each photodiode/transistor pair can be controlled by adjusting the bias voltage applied to each photodiode using a digital-to-analog converter. The gain of each photodiode/transistor pair can be controlled based on the detected temperature of each photodiode.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: May 8, 2018
    Assignee: Waymo LLC
    Inventors: Pierre-yves Droz, Samuel William Lenius
  • Patent number: 9814901
    Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: November 14, 2017
    Assignee: ROCOMP GLOBAL, L.L.C.
    Inventor: Charles Brian Rogers
  • Patent number: 9814902
    Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: November 14, 2017
    Assignee: ROCOMP GLOBAL, L.L.C.
    Inventors: Charles Brian Rogers, Scott David Compton
  • Patent number: 9717927
    Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: August 1, 2017
    Assignee: ROCOMP GLOBAL, L.L.C.
    Inventor: Charles Brian Rogers
  • Patent number: 9547015
    Abstract: Provided herein are compositions, kits, methods and devices for cyanide detection, particularly for cyanide detection in biological samples such as whole blood. The method comprises (1) contacting a sample with a cobinamide conjugate comprising a cobinamide moiety and a carrier; and (2) measuring the absorbance of light by the cobinamide conjugate. The present disclosure provides field-deployable cyanide detection methods, compositions, kits and devices, which provide rapid, accurate readout at the point of contact. Further provided herein is a method for determining exposure of a subject to cyanide.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: January 17, 2017
    Assignee: DIAGNOSTIC CONSULTING NETWORK, INC.
    Inventors: Brendan O'Farrell, Hans Boehringer, Roy Chung, Winnie Tong
  • Patent number: 9400284
    Abstract: A method of detecting a subject's cancer risk is provided. The method includes: gathering a sample of the subject's body water content via saliva; determining a ratio of cyanide within the subject's body water content and tissue saturation via saliva; providing a threshold cyanide ratio; comparing the ratio of cyanide within the subject's body water content and tissue saturation to the threshold cyanide ratio; and determining the patient's cancer risk based on the comparison of the ratio of cyanide within the subject's body water content to the threshold cyanide ratio.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: July 26, 2016
    Inventors: Anthony Sabato Vigliotti, Salvatore Anthony Vigliotti
  • Patent number: 9366634
    Abstract: This invention discloses a substrate enhanced laser-induced breakdown spectroscopy (LIBS) apparatus for liquid analysis. The LIBS apparatus comprises a pulsed laser for producing a laser beam, a substrate made of a material having a high absorption coefficient at the laser wavelength for receiving the liquid sample, an optical lens or mirror for focusing the laser beam onto the liquid sample to produce a plasma emission, and a spectrometer for measuring the optical spectrum of the plasma emission. When the thickness of the liquid sample reaches an optimum value, the plasma emission from the liquid sample is enhanced by the substrate to produce a strong LIBS signal for spectral analysis.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: June 14, 2016
    Assignee: BWT Property, Inc.
    Inventors: Sean Xiaolu Wang, Qun Li
  • Patent number: 9222881
    Abstract: The present invention relates to systems and methods for the determination of the secondary structure composition of proteins using coherent two-dimensional infrared (2DIR) spectroscopy of backbone amide I vibrations (1580-1720 cm?1). Fractions of ?-helix, ?-sheet, and unassigned regions in globular proteins were determined by singular value decomposition using basis spectra from sixteen commercially-available proteins with known crystal structures. Preferred methods included removing each protein from the set and comparing the predicted composition against the crystal structure. The root-mean-squared (RMS) errors of the predicted secondary structure compositions were found to be 7.9% for ?-helix, 5.5% for ?-sheet, and 7.6% for unassigned regions. The structure analysis can also be performed using one-dimensional absorption spectra and the RMS errors are compared with those obtained from 2DIR.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: December 29, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Carlos R. Baiz, Kevin C. Jones, Andrei Tokmakoff
  • Patent number: 9151673
    Abstract: An interferometer system includes an optical bench and at least two mirror structures, being patterned from one or more layers on the optical bench and erected to extend substantially perpendicularly to the bench to define two interferometer arms to provide a Micro-Electro-Mechanical Systems (MEMS) interferometer. The MEMS interferometer is further implemented in a Fourier transform spectrometer, which includes a common housing containing the interferometer and a gas cell, possibly including a preconcentrator.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: October 6, 2015
    Assignee: Block Engineering, LLC
    Inventors: David Reyes, E. Robert Schildkraut, Jinhong Kim
  • Patent number: 9044751
    Abstract: A gene analysis device including an illumination optical system radiating exciting light onto a sample solution; a microfluidic device for forming a bio-reaction space of the sample solution and including at least one micro-chamber in which a reflection pattern is formed; and a detection optical system for detecting a fluorescence signal generated by a bio-reaction in the micro-chamber and comprising a photodetector.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: June 2, 2015
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Won-jong Jung, Sun-ok Jung, Won-seok Chung, Chin-sung Park, Joon-ho Kim, Kak Namkoong
  • Patent number: 9029161
    Abstract: A method and apparatus for dating a body sample, such as blood, includes taking at least one spectroscopic measurement of the sample at at least two predetermined positions in the spectrum having spectral characteristics corresponding to at least two predetermined substances present in the sample that have a time varying relationship with each other. A measured relative concentration of each of the predetermined substances is then determined from the measurement, and the measured relative concentrations of the two predetermined substances is compared with a known variation of the relative concentrations of the two predetermined substances over time. A good fit of the measured relative concentrations to the known variation of the relative concentrations is then determined, so as to provide an indication of the age of the sample. Alternatively, instead of measuring the relative concentrations of each of the predetermined substances, the rate of change of the relative concentrations is determined.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: May 12, 2015
    Assignee: Academisch Medisch Centrum
    Inventors: Maurice Aalders, Rolf Bremmer
  • Patent number: 9029165
    Abstract: A method for detecting electromagnetic waves derived from bacterial DNA, comprising extracting and purifying nucleic acids from a sample; diluting the extracted purified nucleic acids in an aqueous solvent; measuring a low frequency electromagnetic emission over time from the diluted extracted purified nucleic acids in an aqueous solvent; performing a signal analysis of the low frequency electromagnetic emission over time; and producing an output, based on the signal analysis, in dependence on the DNA in the sample. The DNA may be extracted from at least one of blood, feces, urine, saliva, tears, seminal fluid, sweat, seminal and vaginal fluids of a patient, or water to determine, e.g., potability. The samples may be frozen. The extracting and purifying may comprise diluting the sample with an aqueous buffer and mixing; degrading proteins in the diluted sample; precipitating DNA from the buffer solution; and resuspending the precipitated DNA in an aqueous solution.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: May 12, 2015
    Inventor: Luc Montagnier
  • Patent number: 9029473
    Abstract: Disclosed are polyvalent macromolecules, compositions comprising the macromolecules, and methods of use. The polyvalent macromolecules have a polymer backbone and pendent groups attached to the polymer backbone. Some or all of the pendent groups have optionally a linker, a surface-seeking group capable of binding strongly to a metal surface, and a spectroscopically detectable chromophore detectable.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: May 12, 2015
    Assignee: University of Strathclyde
    Inventors: Peter Cormack, Duncan Graham, Aaron Hernandez-Santana, Arun Prasath Ramaswamy, William Ewen Smith
  • Patent number: 9028770
    Abstract: This invention provides a cell made of polymers for spectra measurement while inhibiting a decrease in a molecular weight of resin caused by discharge treatment and having a stable hydrophilic modified surface. The hydrophilic resin cell is prepared by providing a polymeric resin cell between the two opposing electrodes, applying an electric field to a region between the above opposing electrodes under a nitrogen atmosphere with a pressure close to the atmospheric pressure to generate an electric discharge, and exposing the cell subjected to discharge treatment with a gas including oxygen.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: May 12, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Shinichi Taniguchi, Yukimune Takahashi, Takashi Inoue, Hiroaki Ishizawa
  • Publication number: 20150099309
    Abstract: Disclosed is a multi-channel light measurement system adapted to illuminate and measure a test sample in a vessel. The multi-channel light measurement system has at least one photodetector per channel and a variable integrate and hold circuit coupled to each photodetector, the variable integrate and hold circuit allows adjustment of a sampling factor selected from a group of an integration time, a value of capacitance, an area of a discrete photodetector array, or any combination thereof. The system may readily equilibrate reference intensity output for multiple channels. Methods and apparatus are disclosed, as are other aspects.
    Type: Application
    Filed: April 19, 2013
    Publication date: April 9, 2015
    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
    Inventor: Frank Krufka
  • Patent number: 8999652
    Abstract: Mixtures of cell types can be analyzed by having at least two signal markers, with at least one at three different levels to provide a barcode for each cell type. The mixture of cells may be subjected to a common candidate moiety and the effect of the moiety on the cells determined along with identification of the cell by the barcode. Conveniently, surface marker proteins and labeled antibodies can be used to create the barcode and the cells analyzed with flow cytometry.
    Type: Grant
    Filed: August 5, 2008
    Date of Patent: April 7, 2015
    Assignee: Primity Bio, Inc.
    Inventors: Peter Oliver Krutzik, Thomas Scott Wehrman
  • Publication number: 20150079617
    Abstract: The invention relates to a method for determining biochemical parameters of a body fluid, wherein a sample of said body fluid in the form of a droplet is transported through a channel of a microfluidic system using a carrier liquid, mixed with a reagent thus initiating a chemical reaction between the sample and the reagent, and the result of the chemical reaction is measured, preferably with a spectrophotometer, whereby the said biochemical parameters of the body fluid are determined, characterised in that the material used for fabrication of the microfluidic system and the said carrier liquid is pair of Teflon and Fluorinert HFE-7100.
    Type: Application
    Filed: September 12, 2012
    Publication date: March 19, 2015
    Inventors: Piotr Garstecki, Marcin Izydorzak, Magdalena Sulima, Adam Warchulski
  • Patent number: 8951474
    Abstract: The present invention provides an apparatus for analyzing particles in a solution including a unit configured to place a flow cell having a flow path for flowing a sample solution containing the particles; a unit configured to illuminate the sample solution flowing through the flow path of the flow cell; a photodetector that detects a scattered light and/or fluorescence generated from the particles in the sample solution; and a unit configured to analyze the particles based on their signal intensities detected by the photodetector, wherein the flow cell has the flow path formed in a substrate, a reflection plane is formed on the side surface of the flow path, the reflection plane leads the lights generated in the flow path of the flow cell and advancing in the substrate in-plane direction to a specified region of the surface of the flow cell, and the photodetector detects the light exiting from the specified region to the outside.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: February 10, 2015
    Assignee: On-Chip Biotechnologies Co., Ltd.
    Inventor: Kazuo Takeda
  • Patent number: 8951746
    Abstract: The present invention provides multi-parameter analysis methods for determining the presence or absence of pre-cancerous or cancerous cells in a cervical sample and for screening cervical abnormality in a cervical sample. The invention also provides an apparatus and automated methods for screening cervical abnormality in a sample. The invention further provides a sampling device and a sample collection assembly for collecting cell samples, including cervical samples.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: February 10, 2015
    Assignee: Southwest Research Institute
    Inventors: Urs G. Wiederkehr, Jian Ling
  • Patent number: 8953866
    Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: February 10, 2015
    Assignee: Amnis Corporation
    Inventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
  • Patent number: 8951743
    Abstract: The present invention stems from the finding that the extracellular domain of CD31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of CD31. A method for detecting shed CD31 is further disclosed. The invention therefore relates to a method for detecting a shed ectodomain of a transmembrane protein such as CD31 and to the use of such a method as a diagnostic tool. The invention further provides methods for determining whether a candidate protein is part of a molecular complex.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: February 10, 2015
    Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Giuseppina Caligiuri, Antonino Nicoletti
  • Patent number: 8945939
    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: February 3, 2015
    Assignee: Ecolab USA Inc.
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert Mack
  • Patent number: 8940538
    Abstract: The present invention relates to an apparatus for quantifying the binding and dissociation kinetics of molecular interactions of small molecular bio materials with high sensitivity almost without the influence of a change in the reflective index resulting from a buffer solution by making polarized incident light incident on the binding layer of a bio material, formed in a thin dielectric film, so that the polarized incident light satisfies a p-wave non-reflecting condition and a quantifying method using the same.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: January 27, 2015
    Assignee: Korea Research Institute of Standards and Science
    Inventors: Hyun Mo Cho, Gal Won Che, Yong Jai Cho
  • Patent number: 8935007
    Abstract: An analyte testing device is provided for use with a mobile processing device having a camera with a lens, a processor for processing an image captured by the lens. The analyte testing device comprises a casing and a test strip positioner. The test strip positioner positions an analyte containing test strip adjacent to the camera lens to permit the camera to capture an image of the analyte containing test strip. A light source is disposed within the casing. The light source is positioned within the casing to illuminate the analyte containing test strip to facilitate the capture of the image of the test strip. Software is contained within the mobile processing device for performing a quantitative analysis of at least one analyte from the captured image, and providing an output of the results of the quantitative analysis.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: January 13, 2015
    Assignee: 4a medicom GmbH
    Inventors: Hans G. Kloepfer, Thomas Kloepfer, Jason Heim, Reinhard Hafellner
  • Patent number: 8932874
    Abstract: The invention is directed towards methods and compositions for identifying the amount of ammonium acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of ammonium acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of ammonium acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the ammonium acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: January 13, 2015
    Assignee: Nalco Company
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert M. Mack