Spectrum Analysis (e.g., Flame Photometry, Etc.) Patents (Class 436/171)
  • Patent number: 10274424
    Abstract: The present invention provides a Voigt line shape fitting method, including step 1: Calculate a Gauss line shape function and a Lorentz line shape function, and calculate a Voigt line shape function. Step 2: For determined line shape parameters to be fitted, calculate partial derivatives of the Voigt line shape function with respect to the parameters, convert a partial derivative of the Voigt line shape function with respect to a parameter into a partial derivative of the Gauss line shape function or the Lorentz line shape function with respect to the parameter. Step 3: Substitute the Voigt line shape function and the partial derivative of the Voigt line shape function with respect to the parameter to be fitted, into a least squares algorithm step, perform least squares fitting calculation, and determine whether to terminate the least squares fitting calculation or return to step 1 to perform next iterative calculation.
    Type: Grant
    Filed: April 21, 2018
    Date of Patent: April 30, 2019
    Assignee: Space Engineering University
    Inventors: Wei Rao, Guangyu Wang, Yanji Hong, Junling Song
  • Patent number: 10240749
    Abstract: The Invention provides a light source, a luminaire and a surgical illumination unit in which two narrow-band light emitters both emit light in a narrow spectral peak having a full-width-half-maximum equal to or smaller than 40 nanometers. Both of the narrow-band light emitters have a different central emission wavelength within a blue color-range, within a green color range or within a red color-range. At least one of the two narrow-band light emitters comprises a luminescent material for generating the narrow spectral peak. The light source is further configured such that a distance between the narrow spectral peaks of the two narrow-band light emitters prevents overlap of the narrow spectral peaks. Due to the individual narrow spectral peaks, a color contrast within one of the color-ranges is significantly enhanced.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: March 26, 2019
    Assignee: PHILIPS LIGHTING HOLDING B.V.
    Inventors: Ties Van Bommel, Rifat Ata Mustafa Hikmet
  • Patent number: 10234382
    Abstract: A method and kit are provided for diagnosing and monitoring the progress of COPD using FTIR spectral analysis of sputum samples where spectral data is obtained and used to monitor the progression of the disease over time.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: March 19, 2019
    Assignee: PULMONIR LIMITED
    Inventor: Paul Lewis
  • Patent number: 10156479
    Abstract: Systems, methods and other embodiments associated with spatial-domain Low-coherence Quantitative Phase Microscopy (SL-QPM) are described herein. SL-QPM can detect structural alterations within cell nuclei with nanoscale sensitivity (0.9 nm) (or nuclear nano-morphology) for “nano-pathological diagnosis” of cancer. SL-QPM uses original, unmodified cytology and histology specimens prepared with standard clinical protocols and stains. SL-QPM can easily integrate in existing clinical pathology laboratories. Results quantified the spatial distribution of optical path length or refractive index in individual nuclei with nanoscale sensitivity, which could be applied to studying nuclear nano-morphology as cancer progresses. The nuclear nano-morphology derived from SL-QPM offers significant diagnostic value in clinical care and subcellular mechanistic insights for basic and translational research. Techniques that provide for depth selective investigation of nuclear and other cellular features are disclosed.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: December 18, 2018
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Yang Liu, Randall E. Brand, Hoa V. Pham, Shikhar Fnu
  • Patent number: 9964632
    Abstract: A light detection and ranging (LIDAR) system can emit light toward an environment and detect responsively reflected light to determine a distance to one or more points in the environment. The reflected light can be detected by a plurality of plurality of photodiodes that are reverse-biased using a high voltage. Signals from the plurality of reverse-biased photodiodes can be amplified by respective transistors and applied to an analog-to-digital converter (ADC). The signal from a particular photodiode can be applied to the ADC by biasing a respective transistor corresponding to the particular photodiode while not biasing transistors corresponding to other photodiodes. The gain of each photodiode/transistor pair can be controlled by adjusting the bias voltage applied to each photodiode using a digital-to-analog converter. The gain of each photodiode/transistor pair can be controlled based on the detected temperature of each photodiode.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: May 8, 2018
    Assignee: Waymo LLC
    Inventors: Pierre-yves Droz, Samuel William Lenius
  • Patent number: 9814902
    Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: November 14, 2017
    Assignee: ROCOMP GLOBAL, L.L.C.
    Inventors: Charles Brian Rogers, Scott David Compton
  • Patent number: 9814901
    Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: November 14, 2017
    Assignee: ROCOMP GLOBAL, L.L.C.
    Inventor: Charles Brian Rogers
  • Patent number: 9717927
    Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: August 1, 2017
    Assignee: ROCOMP GLOBAL, L.L.C.
    Inventor: Charles Brian Rogers
  • Patent number: 9547015
    Abstract: Provided herein are compositions, kits, methods and devices for cyanide detection, particularly for cyanide detection in biological samples such as whole blood. The method comprises (1) contacting a sample with a cobinamide conjugate comprising a cobinamide moiety and a carrier; and (2) measuring the absorbance of light by the cobinamide conjugate. The present disclosure provides field-deployable cyanide detection methods, compositions, kits and devices, which provide rapid, accurate readout at the point of contact. Further provided herein is a method for determining exposure of a subject to cyanide.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: January 17, 2017
    Assignee: DIAGNOSTIC CONSULTING NETWORK, INC.
    Inventors: Brendan O'Farrell, Hans Boehringer, Roy Chung, Winnie Tong
  • Patent number: 9400284
    Abstract: A method of detecting a subject's cancer risk is provided. The method includes: gathering a sample of the subject's body water content via saliva; determining a ratio of cyanide within the subject's body water content and tissue saturation via saliva; providing a threshold cyanide ratio; comparing the ratio of cyanide within the subject's body water content and tissue saturation to the threshold cyanide ratio; and determining the patient's cancer risk based on the comparison of the ratio of cyanide within the subject's body water content to the threshold cyanide ratio.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: July 26, 2016
    Inventors: Anthony Sabato Vigliotti, Salvatore Anthony Vigliotti
  • Patent number: 9366634
    Abstract: This invention discloses a substrate enhanced laser-induced breakdown spectroscopy (LIBS) apparatus for liquid analysis. The LIBS apparatus comprises a pulsed laser for producing a laser beam, a substrate made of a material having a high absorption coefficient at the laser wavelength for receiving the liquid sample, an optical lens or mirror for focusing the laser beam onto the liquid sample to produce a plasma emission, and a spectrometer for measuring the optical spectrum of the plasma emission. When the thickness of the liquid sample reaches an optimum value, the plasma emission from the liquid sample is enhanced by the substrate to produce a strong LIBS signal for spectral analysis.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: June 14, 2016
    Assignee: BWT Property, Inc.
    Inventors: Sean Xiaolu Wang, Qun Li
  • Patent number: 9222881
    Abstract: The present invention relates to systems and methods for the determination of the secondary structure composition of proteins using coherent two-dimensional infrared (2DIR) spectroscopy of backbone amide I vibrations (1580-1720 cm?1). Fractions of ?-helix, ?-sheet, and unassigned regions in globular proteins were determined by singular value decomposition using basis spectra from sixteen commercially-available proteins with known crystal structures. Preferred methods included removing each protein from the set and comparing the predicted composition against the crystal structure. The root-mean-squared (RMS) errors of the predicted secondary structure compositions were found to be 7.9% for ?-helix, 5.5% for ?-sheet, and 7.6% for unassigned regions. The structure analysis can also be performed using one-dimensional absorption spectra and the RMS errors are compared with those obtained from 2DIR.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: December 29, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Carlos R. Baiz, Kevin C. Jones, Andrei Tokmakoff
  • Patent number: 9151673
    Abstract: An interferometer system includes an optical bench and at least two mirror structures, being patterned from one or more layers on the optical bench and erected to extend substantially perpendicularly to the bench to define two interferometer arms to provide a Micro-Electro-Mechanical Systems (MEMS) interferometer. The MEMS interferometer is further implemented in a Fourier transform spectrometer, which includes a common housing containing the interferometer and a gas cell, possibly including a preconcentrator.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: October 6, 2015
    Assignee: Block Engineering, LLC
    Inventors: David Reyes, E. Robert Schildkraut, Jinhong Kim
  • Patent number: 9044751
    Abstract: A gene analysis device including an illumination optical system radiating exciting light onto a sample solution; a microfluidic device for forming a bio-reaction space of the sample solution and including at least one micro-chamber in which a reflection pattern is formed; and a detection optical system for detecting a fluorescence signal generated by a bio-reaction in the micro-chamber and comprising a photodetector.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: June 2, 2015
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Won-jong Jung, Sun-ok Jung, Won-seok Chung, Chin-sung Park, Joon-ho Kim, Kak Namkoong
  • Patent number: 9029161
    Abstract: A method and apparatus for dating a body sample, such as blood, includes taking at least one spectroscopic measurement of the sample at at least two predetermined positions in the spectrum having spectral characteristics corresponding to at least two predetermined substances present in the sample that have a time varying relationship with each other. A measured relative concentration of each of the predetermined substances is then determined from the measurement, and the measured relative concentrations of the two predetermined substances is compared with a known variation of the relative concentrations of the two predetermined substances over time. A good fit of the measured relative concentrations to the known variation of the relative concentrations is then determined, so as to provide an indication of the age of the sample. Alternatively, instead of measuring the relative concentrations of each of the predetermined substances, the rate of change of the relative concentrations is determined.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: May 12, 2015
    Assignee: Academisch Medisch Centrum
    Inventors: Maurice Aalders, Rolf Bremmer
  • Patent number: 9029165
    Abstract: A method for detecting electromagnetic waves derived from bacterial DNA, comprising extracting and purifying nucleic acids from a sample; diluting the extracted purified nucleic acids in an aqueous solvent; measuring a low frequency electromagnetic emission over time from the diluted extracted purified nucleic acids in an aqueous solvent; performing a signal analysis of the low frequency electromagnetic emission over time; and producing an output, based on the signal analysis, in dependence on the DNA in the sample. The DNA may be extracted from at least one of blood, feces, urine, saliva, tears, seminal fluid, sweat, seminal and vaginal fluids of a patient, or water to determine, e.g., potability. The samples may be frozen. The extracting and purifying may comprise diluting the sample with an aqueous buffer and mixing; degrading proteins in the diluted sample; precipitating DNA from the buffer solution; and resuspending the precipitated DNA in an aqueous solution.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: May 12, 2015
    Inventor: Luc Montagnier
  • Patent number: 9028770
    Abstract: This invention provides a cell made of polymers for spectra measurement while inhibiting a decrease in a molecular weight of resin caused by discharge treatment and having a stable hydrophilic modified surface. The hydrophilic resin cell is prepared by providing a polymeric resin cell between the two opposing electrodes, applying an electric field to a region between the above opposing electrodes under a nitrogen atmosphere with a pressure close to the atmospheric pressure to generate an electric discharge, and exposing the cell subjected to discharge treatment with a gas including oxygen.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: May 12, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Shinichi Taniguchi, Yukimune Takahashi, Takashi Inoue, Hiroaki Ishizawa
  • Patent number: 9029473
    Abstract: Disclosed are polyvalent macromolecules, compositions comprising the macromolecules, and methods of use. The polyvalent macromolecules have a polymer backbone and pendent groups attached to the polymer backbone. Some or all of the pendent groups have optionally a linker, a surface-seeking group capable of binding strongly to a metal surface, and a spectroscopically detectable chromophore detectable.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: May 12, 2015
    Assignee: University of Strathclyde
    Inventors: Peter Cormack, Duncan Graham, Aaron Hernandez-Santana, Arun Prasath Ramaswamy, William Ewen Smith
  • Publication number: 20150099309
    Abstract: Disclosed is a multi-channel light measurement system adapted to illuminate and measure a test sample in a vessel. The multi-channel light measurement system has at least one photodetector per channel and a variable integrate and hold circuit coupled to each photodetector, the variable integrate and hold circuit allows adjustment of a sampling factor selected from a group of an integration time, a value of capacitance, an area of a discrete photodetector array, or any combination thereof. The system may readily equilibrate reference intensity output for multiple channels. Methods and apparatus are disclosed, as are other aspects.
    Type: Application
    Filed: April 19, 2013
    Publication date: April 9, 2015
    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
    Inventor: Frank Krufka
  • Patent number: 8999652
    Abstract: Mixtures of cell types can be analyzed by having at least two signal markers, with at least one at three different levels to provide a barcode for each cell type. The mixture of cells may be subjected to a common candidate moiety and the effect of the moiety on the cells determined along with identification of the cell by the barcode. Conveniently, surface marker proteins and labeled antibodies can be used to create the barcode and the cells analyzed with flow cytometry.
    Type: Grant
    Filed: August 5, 2008
    Date of Patent: April 7, 2015
    Assignee: Primity Bio, Inc.
    Inventors: Peter Oliver Krutzik, Thomas Scott Wehrman
  • Publication number: 20150079617
    Abstract: The invention relates to a method for determining biochemical parameters of a body fluid, wherein a sample of said body fluid in the form of a droplet is transported through a channel of a microfluidic system using a carrier liquid, mixed with a reagent thus initiating a chemical reaction between the sample and the reagent, and the result of the chemical reaction is measured, preferably with a spectrophotometer, whereby the said biochemical parameters of the body fluid are determined, characterised in that the material used for fabrication of the microfluidic system and the said carrier liquid is pair of Teflon and Fluorinert HFE-7100.
    Type: Application
    Filed: September 12, 2012
    Publication date: March 19, 2015
    Inventors: Piotr Garstecki, Marcin Izydorzak, Magdalena Sulima, Adam Warchulski
  • Patent number: 8951746
    Abstract: The present invention provides multi-parameter analysis methods for determining the presence or absence of pre-cancerous or cancerous cells in a cervical sample and for screening cervical abnormality in a cervical sample. The invention also provides an apparatus and automated methods for screening cervical abnormality in a sample. The invention further provides a sampling device and a sample collection assembly for collecting cell samples, including cervical samples.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: February 10, 2015
    Assignee: Southwest Research Institute
    Inventors: Urs G. Wiederkehr, Jian Ling
  • Patent number: 8951474
    Abstract: The present invention provides an apparatus for analyzing particles in a solution including a unit configured to place a flow cell having a flow path for flowing a sample solution containing the particles; a unit configured to illuminate the sample solution flowing through the flow path of the flow cell; a photodetector that detects a scattered light and/or fluorescence generated from the particles in the sample solution; and a unit configured to analyze the particles based on their signal intensities detected by the photodetector, wherein the flow cell has the flow path formed in a substrate, a reflection plane is formed on the side surface of the flow path, the reflection plane leads the lights generated in the flow path of the flow cell and advancing in the substrate in-plane direction to a specified region of the surface of the flow cell, and the photodetector detects the light exiting from the specified region to the outside.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: February 10, 2015
    Assignee: On-Chip Biotechnologies Co., Ltd.
    Inventor: Kazuo Takeda
  • Patent number: 8953866
    Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: February 10, 2015
    Assignee: Amnis Corporation
    Inventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
  • Patent number: 8951743
    Abstract: The present invention stems from the finding that the extracellular domain of CD31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of CD31. A method for detecting shed CD31 is further disclosed. The invention therefore relates to a method for detecting a shed ectodomain of a transmembrane protein such as CD31 and to the use of such a method as a diagnostic tool. The invention further provides methods for determining whether a candidate protein is part of a molecular complex.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: February 10, 2015
    Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Giuseppina Caligiuri, Antonino Nicoletti
  • Patent number: 8945939
    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: February 3, 2015
    Assignee: Ecolab USA Inc.
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert Mack
  • Patent number: 8940538
    Abstract: The present invention relates to an apparatus for quantifying the binding and dissociation kinetics of molecular interactions of small molecular bio materials with high sensitivity almost without the influence of a change in the reflective index resulting from a buffer solution by making polarized incident light incident on the binding layer of a bio material, formed in a thin dielectric film, so that the polarized incident light satisfies a p-wave non-reflecting condition and a quantifying method using the same.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: January 27, 2015
    Assignee: Korea Research Institute of Standards and Science
    Inventors: Hyun Mo Cho, Gal Won Che, Yong Jai Cho
  • Patent number: 8935007
    Abstract: An analyte testing device is provided for use with a mobile processing device having a camera with a lens, a processor for processing an image captured by the lens. The analyte testing device comprises a casing and a test strip positioner. The test strip positioner positions an analyte containing test strip adjacent to the camera lens to permit the camera to capture an image of the analyte containing test strip. A light source is disposed within the casing. The light source is positioned within the casing to illuminate the analyte containing test strip to facilitate the capture of the image of the test strip. Software is contained within the mobile processing device for performing a quantitative analysis of at least one analyte from the captured image, and providing an output of the results of the quantitative analysis.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: January 13, 2015
    Assignee: 4a medicom GmbH
    Inventors: Hans G. Kloepfer, Thomas Kloepfer, Jason Heim, Reinhard Hafellner
  • Patent number: 8932874
    Abstract: The invention is directed towards methods and compositions for identifying the amount of ammonium acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of ammonium acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of ammonium acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the ammonium acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: January 13, 2015
    Assignee: Nalco Company
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert M. Mack
  • Patent number: 8921117
    Abstract: A method for determining the amount of hydrocarbons in a composition including hydrocarbons and water is provided. The method includes adding a chemical agent to the composition in order to form an emulsion of water and hydrocarbons, taking a sample of the emulsion and dissolving this sample in a common solvent for water and hydrocarbons in order to form a solution, and measuring the amount of hydrocarbons in the solution. An installation suitable for implementing this method is also provided.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: December 30, 2014
    Assignee: Total S.A.
    Inventors: Maurice Bourrel, Jean-Michel Gras
  • Patent number: 8906690
    Abstract: A method for estimating characteristics of a formation including collecting a formation sample, preparing the sample, and analyzing the sample using FTIR comprising identifying the kerogen lineshape and intensity. The method includes using the lineshape to obtain kerogen maturity, using the maturity to obtain the kerogen spectrum, and using the kerogen spectrum to obtain the mineralogy and kerogen content.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: December 9, 2014
    Assignee: Schlumberger Technology Corporation
    Inventor: Andrew E. Pomerantz
  • Patent number: 8865470
    Abstract: The present invention reagents and methods for setting up an instruments having a multiplicity of detector channels for analyzing a multiplicity of fluorescent dyes. The present invention is particularly applicable in the field of flow cytometry.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: October 21, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Ming Yan, Alan M. Stall, Joseph T. Trotter, Robert A. Hoffman
  • Patent number: 8859291
    Abstract: The invention provides methods for isolating a target molecule from a sample. In an embodiment, the method involves contacting a sample with a capture agent, the agent comprising a siderophore and a transition metal cation, under conditions wherein the agent is capable of binding a target molecule to form a target molecule-capture agent complex, wherein the target molecule is selected from the group consisting of a phosphorylated molecule, a nitrotyrosine-containing molecule and a sulfated molecule, and separating the target molecule-capture agent complex from the sample, thereby isolating the target molecule from the sample. Also provided are methods for determining the presence of a target molecule in a sample, that involve contacting a sample with a capture agent, the agent comprising a siderophore and a transition metal cation.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: October 14, 2014
    Assignee: PerkinElmer LAS, Inc.
    Inventors: Roger Bossé, Wayne F. Patton, Philippe Roby
  • Patent number: 8846407
    Abstract: A method and device for detecting explosive compounds in an air sample in which the air sample is filtered with activated carbon treated with a weakly basic solution, after which the air sample is divided into two parts, with one part being heated at lower temperatures to decompose non-explosive nitrogenous compounds and the second part being heated at higher temperatures to decompose explosive nitrogenous compounds. Nitrogen dioxide is measured in both portions of the air sample with a spectrographic detector, and the presence or absence of explosive nitrogenous compounds in the air sample is determined.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: September 30, 2014
    Inventor: James M. Hargrove
  • Patent number: 8836938
    Abstract: The description relates to a standard for wavelength and intensity for spectrometers, particularly for calibrating and testing measurement heads in spectrometers which are usable primarily in the near infrared region (NIR) of the spectrum. The standard comprises a holder and a plate body arranged in the holder. The plate body is made of transparent plastic with high strength and dimensional stability over a large temperature range. The plastic has distinct absorption bands throughout the entire NIR range and has a chemical structure and composition ensuring an extensive moisture barrier against water absorption and water release in a reliable and stable manner over time. The plate body advantageously comprises an amorphous, transparent copolymer based on cyclic and/or linear olefins.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: September 16, 2014
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Wilhelm Schebesta, Nico Correns, Lutz Freytag, Michael Rode
  • Patent number: 8828737
    Abstract: Methods for using focused light scattering techniques for the optical sensing of biological particles suspended in a liquid medium are disclosed. The optical sensing enables one to characterize particles size and/or distribution in a given sample. This, in turn, allows one to identify the biological particles, determine their relative particle density, detect particle shedding, and identify particle aggregation. The methods are also useful in screening and optimizing drug candidates, evaluating the efficacy and dosage levels of such drugs, and in personalized medicine applications.
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: September 9, 2014
    Assignee: Invitrox, Inc.
    Inventor: Don Gabriel
  • Patent number: 8824770
    Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: September 2, 2014
    Assignee: Amnis Corporation
    Inventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
  • Patent number: 8815233
    Abstract: A method of utilizing the chymotrypsin level of an individual as a measure of the success of secretin, other neuropeptides, and peptides or digestive enzyme administration to such individuals, and in particular, as a prognosticative of potential secretin, other neuropeptides, peptides, and digestive enzyme administration for persons having ADD, ADHD, Autism and other PDD related disorders.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: August 26, 2014
    Assignee: Curemark LLC
    Inventor: Joan M. Fallon
  • Publication number: 20140234983
    Abstract: The present invention relates to a method of obtaining metal nanoparticles functionalized with fluorescent organic molecules by means of the treatment of one or more metal salts with a reducing agent in the presence of a fluorescent organic molecule. The invention also relates to the metal nanoparticles obtainable by said method and to their use for detecting molecules and analytes.
    Type: Application
    Filed: March 23, 2012
    Publication date: August 21, 2014
    Applicants: UNIVERSIDAD PABLO DE OLAVIDE, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS C.S.I.C.
    Inventors: Ana Paula Zaderenko Partida, Carlos Caro Salazar, José Mejías Romero, Maria Jesús Sayagués De Vega
  • Patent number: 8796040
    Abstract: A system of quantitatively determining a biomolecule, which has: allowing fluorescent silica particles capable of emitting fluorescence detectable by a flow cytometer to capture a target biomolecule fluorescent-labelled for quantitative determination; detecting the fluorescence emitted from the fluorescent silica particles themselves by using the flow cytometer; and measuring the intensity of the fluorescence of the labelled target biomolecule, thereby quantitatively determining the target biomolecule.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: August 5, 2014
    Assignees: The Furukawa Electric Co., Ltd., The University of Tokushima
    Inventors: Hideki Aizawa, Michio Ohkubo, Michihiro Nakamura, Hirokazu Miyoshi
  • Patent number: 8765484
    Abstract: The invention concerns a particle having a code embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: July 1, 2014
    Assignee: The Regents of the University of California
    Inventors: Michael J. Sailor, Thomas Schmedake, Frederique Cunin, Jamie Link
  • Patent number: 8765392
    Abstract: The present invention relates to methods and kits for diagnosing, ascertaining the clinical course of myelodysplastic syndrome (MDS) and ascertaining response to a therapy regimen of myelodysplastic syndrome. Specifically the invention provides methods and kits useful in the diagnosis and determination of clinical parameters associated with MDS based on surface markers unique to MDS.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: July 1, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jonni Moore, Sundhu Cherian, Adam Bagg
  • Publication number: 20140170070
    Abstract: In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.
    Type: Application
    Filed: February 24, 2014
    Publication date: June 19, 2014
    Inventors: Wei Qian, Makoto Murakami, Yuki Ichikawa, Yong Che
  • Patent number: 8748191
    Abstract: Analytical systems and methods are provided for simultaneously dispensing metered volumes of fluids at different rates and mixing the fluids to generate a mixed sample having the fluids in proportion to the different rates at which they were dispensed. In some cases two or more of the fluids are premixed prior to mixing with other fluids. In some cases a use composition and diluent are simultaneously dispensed at different rates and premixed to form a diluted sample. One or more reagents may be mixed with the diluted sample and the sample mixture can be analyzed to determine characteristics of the use composition.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: June 10, 2014
    Assignee: Ecolab USA Inc.
    Inventors: Paul R. Kraus, William M. Christensen
  • Patent number: 8741662
    Abstract: Methods and kits for diagnosis and prognosis using biomarkers comprising albumin-bound protein/peptide complex (ABPPC).
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: June 3, 2014
    Assignee: The Johns Hopkin University
    Inventors: Jennifer E. Van Eyk, Rebekah Lynn Gundry, Robert J. Cotter
  • Patent number: 8716028
    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: May 6, 2014
    Assignee: Nalco Company
    Inventors: Amy Tseng, Brian V. Jenkins, Robert M. Mack
  • Publication number: 20140113382
    Abstract: The invention relates to the use of a construct for the detection of an analyte using surface enhanced spectroscopic techniques. The construct includes linked surfaces, where the link is formed by a linker providing a fixed inter-surface separation between the linked surfaces, wherein the linker is a linking compound, and at least one of the surfaces is the surface of a nanoparticle. The linking compound is suitable for interacting with the analyte. The linking compound may be a cucurbituril. The surface enhanced spectroscopic technique may be surface enhanced Raman spectroscopy (SERS).
    Type: Application
    Filed: June 24, 2011
    Publication date: April 24, 2014
    Applicant: CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Richard William Taylor, Jeremy John Baumberg, Sumeet Mahajan, Tung-Chun Lee, Oren Alexander Scherman, Setu Kasera, Roger Coulston
  • Patent number: 8697452
    Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: April 15, 2014
    Assignee: Life Technologies Corporation
    Inventors: John Linton, Arrin Katz, Colin Brenan, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya Kanigan, Kristine Friesen, Thomas Morrison, Javier Garcia
  • Patent number: 8691591
    Abstract: Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.
    Type: Grant
    Filed: March 25, 2013
    Date of Patent: April 8, 2014
    Assignee: Trustees of Tufts College
    Inventors: David R. Walt, Todd A. Dickinson
  • Publication number: 20140057362
    Abstract: Lateral flow assay analysis is shown and described. In one embodiment, the lateral flow assay comprises a surface having a reflectance profile that is adapted to enable monitoring of the assay continuously until the detection of an analyte. In other embodiments, a lateral flow assay system includes an incubator and a reader, wherein the incubator incubates the assay concurrently as the reader generates a test result. Further, an assay measurement apparatus may include an optical detector to perform continuous image detection of the assay to generate a diagnostic test result.
    Type: Application
    Filed: August 25, 2011
    Publication date: February 27, 2014
    Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington