Abstract: A method of super-resolution microscopy is provided. The method includes mapping three-dimensional location of each single emission event in a plurality of single emission events from a series of optical images of a sample to create a point cloud. The point cloud is filtered or refined. Clusters within the point cloud are identified and characterized allowing for an assessment of molecular architecture.

Abstract: A biological material measuring instrument is described. The biological material measuring instrument includes a rotating body and a main body. The rotating body includes one or more cartridge holders having cuvettes in which a reagent and an analyte in a sample react. The main body includes a pair of light-emitting parts and light-receiving parts to optically measure the analyte in the sample. The rotating body further includes a light-emitting optical waveguide for guiding the light of the light-emitting parts to the cuvette, and a light-receiving optical waveguide for guiding.

Abstract: Described systems and techniques provide for tracking respective medical events such as a patient's pathology specimen etc., based on a unique medical event tracking number throughout the diagnosis and treatment associated with that specimen. The system and technique generation of living reports of patient health conditions that enables medical event-based tracking in a manner that substantially improves medical care by facilitating “closing-the-loop” between the many medical service providers and the laboratories that may be involved in a particular diagnosis and treatment.

Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. There have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy or polynucleotide sequencing applications.

Abstract: After setting an intensity value equal to or lower than a predetermined level in mass spectrum data as invalid data, an uncompressed data array in which intensity values are arrayed in the order of m/z is divided into blocks per predetermined number of pieces of data. When significant intensity values are consecutive in order from the start of each block, this consecutive number and the respective intensity values are used as data for compression. When invalid data is consecutive, this consecutive number is used as data for compression. Then, sequence numbers of data at the start of each block after compression are collected to create an index and the index is stored together with the compressed data.

Abstract: The present invention relates to a system and a method for abating the presence of a selected chemical substance in wastewater flowing in a wastewater channel system from an upstream position to a downstream position. The method typically comprising dosing into the wastewater, at the upstream position, chemical agent(s) adapted to abate the presence of said selected chemical substance, wherein the dosing is in an amount set by a dosing set-point, and adjusting the dosing set-point based on determinations of the concentration of the selected chemical substance at the downstream position. The invention involves comparison between a determined concentration and a pre-selected fractile and adjusting a dosing set-point based thereon.

Abstract: Methods, apparatuses and systems for calibrating gas detectors are disclosed. An example calibration apparatus may have a gas supply element configured to provide a background gaseous substance within at least a portion of the calibration apparatus, a nebulizing element configured to generate the testing gaseous substance by transforming a testing solution in conjunction with the background gaseous substance, a pressure control element configured to regulate airflow in order to maintain a constant air pressure within the at least a portion of the calibration apparatus, and a controller component in electronic communication with the gas supply element, the nebulizing element and the pressure control element.

Abstract: An apparatus for electroporation of biological cells is provided. The apparatus includes a sample container having an insulator chamber for holding the cells. The sample container has a first electrode and a second electrode to provide electrical connection for electroporation. The insulator chamber is configured to contain at least one cell monolayer. The apparatus also includes a pulse generator that can generate a predetermined pulse for electroporation of the cells.

Abstract: Chronic Kidney Disease (CKD) is characterized by the progressive loss of renal function which eventually leads to End Stage Renal Disease (ESRD). CKD affects roughly 30 million Americans, costs billions of dollars in healthcare spending annually, and leaves thousands of patients reliant on burdensome dialysis treatments while waiting for a transplant. Fortunately, CKD may be controllable if diagnosed early in the disease progression. RAMETRIX™ is a novel public health screening technology for early diagnosis and detection of CKD. This technology uses Raman spectroscopy and chemometrics to analyze the molecular composition of urine and other biological fluids. RAMETRIX™ is a fast, non-invasive, accurate, and inexpensive diagnostic tool that can revolutionize the way healthcare providers detect and treat CKD. The RAMETRIX™ AutoScanner is a system enabling more efficient sample processing in large-scale settings such as hospitals and medical laboratories.

Abstract: Disclosed in the present invention are a method and system for evaluating a fractal dimension of particle matter in a dispersing system. The method includes: setting that distribution of a particle radius r of particle matter in a dispersing system obeys logarithmic normal distribution lnr˜N(?, ?2) with an expectation ? and a standard deviation ?, and determining the value of the standard deviation ?; and evaluating a fractal dimension Dƒ of the dispersing system on the basis of the standard deviation ?, an evaluation formula being: Dƒ=1/?. The present invention provides the formula for evaluating the fractal dimension of particle distribution in a dispersing system. When the formula is used to calculate a fractal dimension, only particle radius distribution of particle matter needs to be measured, and no geometrical morphology feature parameter of the particle matter needs to be measured. Factors such as particle morphology and the like do not affect the fractal dimension.

Abstract: A state determination apparatus includes: electrodes configured to apply AC signal to a mixture; a measurement unit configured to measure an impedance of the mixture for every frequency of the AC signal based on a response signal flowing through the mixture when the AC signal is applied; a setting unit configured to set an equivalent circuit including one or a plurality of parallel circuit(s) based on element(s) corresponding to electrical component(s) of a solid matter; a calculating unit configured to calculate a parameter of the parallel circuit by executing an equivalent circuit analysis for approximating impedance of the equivalent circuit to the impedance of the mixture; and a derivation unit configured to derive an index for specifying a state of the mixture based on the parameter of the parallel circuit.

Abstract: A method of determining a disinfectant composition of a municipal water supply from a water sample that includes: (a) obtaining a water sample from a water source at a sampling location; (b) adding a chlorine-containing material to the water sample in the presence of an oxidation reduction potential (ORP) measurement device; (c) generating a plurality of ORP measurements during addition of the chlorine-containing material to the water sample; (d) estimating a concentration of one or more of free ammonia, fully combined ammonia, monochloramine, or a mixture of dichloroamine and trichloroamine in the water sample in which the estimation is derived from the relationship between the added chlorine material and the plurality of ORP measurements; and (e) determining a disinfectant composition of the water source at the water sampling location from the concentration calculation. A method of determining free ammonia composition is also included.

Abstract: Disclosed herein are methods for measuring the ionic strengths of the natural water sources. Also disclosed herein are systems used to measure an ionic strength of the natural water sources. More specifically disclosed herein are methods and systems utilizing spectroscopic pH measurements and calculations of the ionic strength as a function of the measured pH.

Abstract: A method of analyzing a polymer resin comprising: providing a polymer resin sample having two or more polymer components; subjecting the sample to aTREF analysis to yield aTREF elution trace by contacting the sample with aTREF solvent to form sample solution; introducing sample solution into aTREF column and allowing elution of polymer components at different elution rates along the column; eluting from the aTREF column an aTREF eluent comprising the polymer components eluting at different rates; and subjecting the aTREF eluent to IR detection to yield the aTREF elution trace; identifying the components of the sample to yield identified components by comparing the elution trace with an identification library that comprises a plurality of known polymer aTREF elution traces correlated with known polymer components characterized by identifying parameters (density, SCB, crystallization temperature, MI, HLMI, MWD); and quantifying each of the identified components to yield quantified polymer components via chemome

Abstract: A laser radiation system according to a viewpoint of the present disclosure includes a first optical system configured to convert a first laser flux into a second laser flux, a multimirror device including mirrors, configured to be capable of controlling the angle of the attitude of each of the mirrors, and configured to divide the second laser flux into laser fluxes and reflect the laser fluxes in directions to produce the divided laser fluxes, a Fourier transform optical system configured to focus the divided laser fluxes, and a control section configured to control the angle of the attitude of each of the mirrors in such a way that the Fourier transform optical system superimposes the laser fluxes, which are divided by the mirrors separate from each other by at least a spatial coherence length of the second laser flux, on one another.

Abstract: Disclosed is a localised surface plasmon resonance (LSPR) nanopillar assembly. The LSPR assembly is for use in sensing the presence of a biomarker when attached to a quantum dot. The LSPR assembly comprises a substrate and an array. The array comprises a LSPR nanopillar and a polymer spacer attached to the nanopillar. The LSPR assembly further comprises an antibody attached to the at least one polymer spacer. In the LSPR assembly, a combined height of the polymer spacer and antibody is selected by varying the number of monomer units of the polymer spacer, so that, when in use with the biomarker and the quantum dot, the quantum dot is at a predetermined distance from the nanopillar.

Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.

Abstract: A method is provided for predicting conjunct polymer concentration in spent ionic liquid during a continuous hydrocarbon conversion process.

Abstract: One example provides a fluidic die including a semiconductor substrate, and a nozzle layer disposed on the substrate, the nozzle layer having a top surface opposite the substrate and including a nozzle formed therein, the nozzle including a fluid chamber disposed below the top surface and a nozzle orifice extending through the nozzle layer from the top surface to the fluid chamber, the fluid chamber to hold fluid, and the nozzle to eject fluid drops from the fluid chamber via the nozzle orifice. An electrode is disposed in contact with the nozzle layer about a perimeter of the nozzle orifice, the electrode to carry an electrical charge to adjust movement of electrically charged components of the fluid.

Abstract: Example automated diagnostic analyzers and methods for using the same are disclosed herein. An example apparatus described herein includes a first carousel rotatably coupled to a base and having a first axis of rotation. The example apparatus includes a second carousel rotatably coupled to the base and vertically spaced over the first carousel such that at least a portion of the second carousel is disposed over the first carousel. In the example apparatus, the second carousel has a second axis of rotation and a plurality of vessels. The example apparatus also includes a pipetting mechanism offset from the second axis of rotation. The example pipetting mechanism is to access the first carousel and the second carousel.

Abstract: A method comprises: aspirating a sample through a needle capillary into a chamber having first and second windows, the capillary and chamber both affixed to a moveable robotic arm; causing a light beam generated by a light source that is affixed to the robotic arm to pass through the sample between the windows; detecting, using a photodetector that is affixed to the robotic arm, a quantity of the light that passes through the sample and the windows; determining an optical absorbance of the sample and a concentration of an analyte in the sample from the detected quantity of light; determining a quantity of the sample to dispense into an analytical apparatus based on the determined concentration; moving the robotic arm so as to cause the needle capillary to mate with an inlet port of an analytical apparatus; and dispensing the determined quantity of the sample into the analytical apparatus.

Abstract: Effects of Oxygen on grease or another organic paste product can be evaluated with a modified version of the ASTM D942 test methodology for oxidation stability of lubricating greases or other organic paste products by employment of an oxidation pressure vessel, in which at least one of (A) a very small sample of the grease or other organic paste product is deployed for testing within the oxidation pressure vessel such that the sample has an enhanced surface area to mass ratio, and (B) a temperature other than about 99° C. is employed during the testing. In general, the testing is carried out under oxidation pressure conditions. The sample may be evaluated with respect to Oxygen uptake. Additional technique(s) directed to oxidation and/or other properties of the sample may be carried out before to after any Oxygen uptake evaluation, for example, FTIR analysis and/or ATR-FTIR analysis.

Abstract: Machine learning is performed on input data representing a dynamical statistical system of entities having plural primary variables that vary time. A distribution function over time of the density of entities in a phase space, whose dimensions are the primary variables and secondary variables dependent on the rate of change of the primary variables, is derived and encoded as a sum of contour functions over time describing the contour in phase space of plural phaseons which are entities of a model of the dynamical statistical system that are localised in the phase space. Machine learning is performed on the encoded distribution function and/or at least one field in the effective configuration space whose dimensions are the primary variables, derived from the encoded distribution function. The encoding of the distribution function provides a representation which improves the performance of the machine learning techniques by simplifying hyperparameter optimisation.

Abstract: An artificial intelligence model receives a FTIR spectrum of a given ingredient to predict its protein secondary structure. The model includes three artificial modules, which generate three predicted values corresponding to structural categories (e.g., ?-helix, ?-sheet, and other) of the predicted secondary structure. Proteins may be compared for similarity based on predicted values corresponding to the structural categories of the predicted secondary structure.

Abstract: Embodiments relate generally to an ultraviolet lamp (100) for use with a photoionization detector comprising a sealed tube (102) configured to contain at least one gas; a coating (120) applied to the inner surface (110) of the sealed tube (102); and a crystal window (112) attached to the sealed tube (102), configured to allow transmittance of ultraviolet (UV) light generated within the sealed tube (102).

Abstract: Embodiments relate generally to an ultraviolet lamp (100) for use with a photoionization detector comprising a sealed tube (102) configured to contain at least one gas; a coating (120) applied to the inner surface (110) of the sealed tube (102); and a crystal window (112) attached to the sealed tube (102), configured to allow transmittance of ultraviolet (UV) light generated within the sealed tube (102).

Abstract: A method for analyzing noise spectrum of an electronic device includes storing a waveform data including a plurality of data points, the waveform data is obtained by measuring a target signal from the electronic device, removing data points corresponding to a background noise fluctuation based on a smooth curve of the waveform data, data points considered candidates for peaks are extracted from the waveform data, classifying the extracted data points based on a distance between adjacent data points in order to discriminate a cluster of distant data points from data points closely positioned to dominant peaks, determining the dominant peaks based on the cluster of distant data points such that the data points closely positioned to the dominant peaks are ignored, each dominant peak corresponds to the characteristic of the electronic device, and outputting the dominant peaks as an analysis result for the electronic device.

Abstract: A method for analyzing noise spectrum of an electronic device includes storing a waveform data including a plurality of data points, the waveform data is obtained by measuring a target signal from the electronic device, removing data points corresponding to a background noise fluctuation based on a smooth curve of the waveform data, data points considered candidates for peaks are extracted from the waveform data, classifying the extracted data points based on a distance between adjacent data points in order to discriminate a cluster of distant data points from data points closely positioned to dominant peaks, determining the dominant peaks based on the cluster of distant data points such that the data points closely positioned to the dominant peaks are ignored, each dominant peak corresponds to the characteristic of the electronic device, and outputting the dominant peaks as an analysis result for the electronic device.

Abstract: The present invention provides a Voigt line shape fitting method, including step 1: Calculate a Gauss line shape function and a Lorentz line shape function, and calculate a Voigt line shape function. Step 2: For determined line shape parameters to be fitted, calculate partial derivatives of the Voigt line shape function with respect to the parameters, convert a partial derivative of the Voigt line shape function with respect to a parameter into a partial derivative of the Gauss line shape function or the Lorentz line shape function with respect to the parameter. Step 3: Substitute the Voigt line shape function and the partial derivative of the Voigt line shape function with respect to the parameter to be fitted, into a least squares algorithm step, perform least squares fitting calculation, and determine whether to terminate the least squares fitting calculation or return to step 1 to perform next iterative calculation.

Abstract: The Invention provides a light source, a luminaire and a surgical illumination unit in which two narrow-band light emitters both emit light in a narrow spectral peak having a full-width-half-maximum equal to or smaller than 40 nanometers. Both of the narrow-band light emitters have a different central emission wavelength within a blue color-range, within a green color range or within a red color-range. At least one of the two narrow-band light emitters comprises a luminescent material for generating the narrow spectral peak. The light source is further configured such that a distance between the narrow spectral peaks of the two narrow-band light emitters prevents overlap of the narrow spectral peaks. Due to the individual narrow spectral peaks, a color contrast within one of the color-ranges is significantly enhanced.

Abstract: A method and kit are provided for diagnosing and monitoring the progress of COPD using FTIR spectral analysis of sputum samples where spectral data is obtained and used to monitor the progression of the disease over time.

Abstract: Systems, methods and other embodiments associated with spatial-domain Low-coherence Quantitative Phase Microscopy (SL-QPM) are described herein. SL-QPM can detect structural alterations within cell nuclei with nanoscale sensitivity (0.9 nm) (or nuclear nano-morphology) for “nano-pathological diagnosis” of cancer. SL-QPM uses original, unmodified cytology and histology specimens prepared with standard clinical protocols and stains. SL-QPM can easily integrate in existing clinical pathology laboratories. Results quantified the spatial distribution of optical path length or refractive index in individual nuclei with nanoscale sensitivity, which could be applied to studying nuclear nano-morphology as cancer progresses. The nuclear nano-morphology derived from SL-QPM offers significant diagnostic value in clinical care and subcellular mechanistic insights for basic and translational research. Techniques that provide for depth selective investigation of nuclear and other cellular features are disclosed.

Abstract: A light detection and ranging (LIDAR) system can emit light toward an environment and detect responsively reflected light to determine a distance to one or more points in the environment. The reflected light can be detected by a plurality of plurality of photodiodes that are reverse-biased using a high voltage. Signals from the plurality of reverse-biased photodiodes can be amplified by respective transistors and applied to an analog-to-digital converter (ADC). The signal from a particular photodiode can be applied to the ADC by biasing a respective transistor corresponding to the particular photodiode while not biasing transistors corresponding to other photodiodes. The gain of each photodiode/transistor pair can be controlled by adjusting the bias voltage applied to each photodiode using a digital-to-analog converter. The gain of each photodiode/transistor pair can be controlled based on the detected temperature of each photodiode.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: Provided herein are compositions, kits, methods and devices for cyanide detection, particularly for cyanide detection in biological samples such as whole blood. The method comprises (1) contacting a sample with a cobinamide conjugate comprising a cobinamide moiety and a carrier; and (2) measuring the absorbance of light by the cobinamide conjugate. The present disclosure provides field-deployable cyanide detection methods, compositions, kits and devices, which provide rapid, accurate readout at the point of contact. Further provided herein is a method for determining exposure of a subject to cyanide.

Abstract: A method of detecting a subject's cancer risk is provided. The method includes: gathering a sample of the subject's body water content via saliva; determining a ratio of cyanide within the subject's body water content and tissue saturation via saliva; providing a threshold cyanide ratio; comparing the ratio of cyanide within the subject's body water content and tissue saturation to the threshold cyanide ratio; and determining the patient's cancer risk based on the comparison of the ratio of cyanide within the subject's body water content to the threshold cyanide ratio.

Abstract: This invention discloses a substrate enhanced laser-induced breakdown spectroscopy (LIBS) apparatus for liquid analysis. The LIBS apparatus comprises a pulsed laser for producing a laser beam, a substrate made of a material having a high absorption coefficient at the laser wavelength for receiving the liquid sample, an optical lens or mirror for focusing the laser beam onto the liquid sample to produce a plasma emission, and a spectrometer for measuring the optical spectrum of the plasma emission. When the thickness of the liquid sample reaches an optimum value, the plasma emission from the liquid sample is enhanced by the substrate to produce a strong LIBS signal for spectral analysis.

Abstract: The present invention relates to systems and methods for the determination of the secondary structure composition of proteins using coherent two-dimensional infrared (2DIR) spectroscopy of backbone amide I vibrations (1580-1720 cm?1). Fractions of ?-helix, ?-sheet, and unassigned regions in globular proteins were determined by singular value decomposition using basis spectra from sixteen commercially-available proteins with known crystal structures. Preferred methods included removing each protein from the set and comparing the predicted composition against the crystal structure. The root-mean-squared (RMS) errors of the predicted secondary structure compositions were found to be 7.9% for ?-helix, 5.5% for ?-sheet, and 7.6% for unassigned regions. The structure analysis can also be performed using one-dimensional absorption spectra and the RMS errors are compared with those obtained from 2DIR.

Abstract: An interferometer system includes an optical bench and at least two mirror structures, being patterned from one or more layers on the optical bench and erected to extend substantially perpendicularly to the bench to define two interferometer arms to provide a Micro-Electro-Mechanical Systems (MEMS) interferometer. The MEMS interferometer is further implemented in a Fourier transform spectrometer, which includes a common housing containing the interferometer and a gas cell, possibly including a preconcentrator.

Abstract: A gene analysis device including an illumination optical system radiating exciting light onto a sample solution; a microfluidic device for forming a bio-reaction space of the sample solution and including at least one micro-chamber in which a reflection pattern is formed; and a detection optical system for detecting a fluorescence signal generated by a bio-reaction in the micro-chamber and comprising a photodetector.

Abstract: A method and apparatus for dating a body sample, such as blood, includes taking at least one spectroscopic measurement of the sample at at least two predetermined positions in the spectrum having spectral characteristics corresponding to at least two predetermined substances present in the sample that have a time varying relationship with each other. A measured relative concentration of each of the predetermined substances is then determined from the measurement, and the measured relative concentrations of the two predetermined substances is compared with a known variation of the relative concentrations of the two predetermined substances over time. A good fit of the measured relative concentrations to the known variation of the relative concentrations is then determined, so as to provide an indication of the age of the sample. Alternatively, instead of measuring the relative concentrations of each of the predetermined substances, the rate of change of the relative concentrations is determined.

Abstract: This invention provides a cell made of polymers for spectra measurement while inhibiting a decrease in a molecular weight of resin caused by discharge treatment and having a stable hydrophilic modified surface. The hydrophilic resin cell is prepared by providing a polymeric resin cell between the two opposing electrodes, applying an electric field to a region between the above opposing electrodes under a nitrogen atmosphere with a pressure close to the atmospheric pressure to generate an electric discharge, and exposing the cell subjected to discharge treatment with a gas including oxygen.

Abstract: A method for detecting electromagnetic waves derived from bacterial DNA, comprising extracting and purifying nucleic acids from a sample; diluting the extracted purified nucleic acids in an aqueous solvent; measuring a low frequency electromagnetic emission over time from the diluted extracted purified nucleic acids in an aqueous solvent; performing a signal analysis of the low frequency electromagnetic emission over time; and producing an output, based on the signal analysis, in dependence on the DNA in the sample. The DNA may be extracted from at least one of blood, feces, urine, saliva, tears, seminal fluid, sweat, seminal and vaginal fluids of a patient, or water to determine, e.g., potability. The samples may be frozen. The extracting and purifying may comprise diluting the sample with an aqueous buffer and mixing; degrading proteins in the diluted sample; precipitating DNA from the buffer solution; and resuspending the precipitated DNA in an aqueous solution.

Abstract: Disclosed are polyvalent macromolecules, compositions comprising the macromolecules, and methods of use. The polyvalent macromolecules have a polymer backbone and pendent groups attached to the polymer backbone. Some or all of the pendent groups have optionally a linker, a surface-seeking group capable of binding strongly to a metal surface, and a spectroscopically detectable chromophore detectable.

Abstract: Disclosed is a multi-channel light measurement system adapted to illuminate and measure a test sample in a vessel. The multi-channel light measurement system has at least one photodetector per channel and a variable integrate and hold circuit coupled to each photodetector, the variable integrate and hold circuit allows adjustment of a sampling factor selected from a group of an integration time, a value of capacitance, an area of a discrete photodetector array, or any combination thereof. The system may readily equilibrate reference intensity output for multiple channels. Methods and apparatus are disclosed, as are other aspects.

Abstract: Mixtures of cell types can be analyzed by having at least two signal markers, with at least one at three different levels to provide a barcode for each cell type. The mixture of cells may be subjected to a common candidate moiety and the effect of the moiety on the cells determined along with identification of the cell by the barcode. Conveniently, surface marker proteins and labeled antibodies can be used to create the barcode and the cells analyzed with flow cytometry.

Abstract: The invention relates to a method for determining biochemical parameters of a body fluid, wherein a sample of said body fluid in the form of a droplet is transported through a channel of a microfluidic system using a carrier liquid, mixed with a reagent thus initiating a chemical reaction between the sample and the reagent, and the result of the chemical reaction is measured, preferably with a spectrophotometer, whereby the said biochemical parameters of the body fluid are determined, characterised in that the material used for fabrication of the microfluidic system and the said carrier liquid is pair of Teflon and Fluorinert HFE-7100.

Abstract: The present invention provides an apparatus for analyzing particles in a solution including a unit configured to place a flow cell having a flow path for flowing a sample solution containing the particles; a unit configured to illuminate the sample solution flowing through the flow path of the flow cell; a photodetector that detects a scattered light and/or fluorescence generated from the particles in the sample solution; and a unit configured to analyze the particles based on their signal intensities detected by the photodetector, wherein the flow cell has the flow path formed in a substrate, a reflection plane is formed on the side surface of the flow path, the reflection plane leads the lights generated in the flow path of the flow cell and advancing in the substrate in-plane direction to a specified region of the surface of the flow cell, and the photodetector detects the light exiting from the specified region to the outside.