Spectrum Analysis (e.g., Flame Photometry, Etc.) Patents (Class 436/171)
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Patent number: 8426211Abstract: The present invention relates to a method of detecting soil nutrients or soil nutrients in soil from reflected light, and also includes systems for the measurement, calculation and transmission of data relating to or carrying out that method.Type: GrantFiled: February 8, 2010Date of Patent: April 23, 2013Assignee: Bowling Green State UniversityInventors: B. B. Maruthi Sridhar, Robert K. Vincent
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Patent number: 8426217Abstract: Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.Type: GrantFiled: August 23, 2011Date of Patent: April 23, 2013Assignee: Trustees of Tufts CollegeInventors: David R. Walt, Todd A. Dickinson
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Patent number: 8415161Abstract: The present invention reagents and methods for setting up an instruments having a multiplicity of detector channels for analyzing a multiplicity of fluorescent dyes. The present invention is particularly applicable in the field of flow cytometry.Type: GrantFiled: November 10, 2009Date of Patent: April 9, 2013Assignee: Becton, Dickinson and CompanyInventors: Ming Yan, Alan M. Stall, Joseph T. Trotter, Robert A. Hoffman
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Patent number: 8409863Abstract: A system to selectively deliver relatively small analyte molecules of interest to a SERS-active nanoparticle surface while excluding dozens to hundreds of other species in the environment. In particular, the present invention provides a permselective film that renders the particles of interest as viable small molecule optically addressable sensors.Type: GrantFiled: December 14, 2006Date of Patent: April 2, 2013Assignee: Becton, Dickinson and CompanyInventors: Michael J. Natan, Marcelo Eduardo Piotti
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Patent number: 8404488Abstract: The invention is provided for detection of Heroin and Morphine in illicit drug samples, also for their differentiation. A liquid sample from a street sample is prepared and divided into two equal aliquots, one of them being reference sample, another being main sample. Both samples are treated with Hydrochloric acid and Sodium hydroxide, but those substances are added to the samples in the different sequence. After that the measurement of SFS of the reference sample is performed. Further the presence of specific spectral pattern of Morphine in the measured SFS of the reference, sample is detected and the value of SFS intensity at the specific spectral point is fixed (a reference value). After 15 minutes for acidification of the main sample, the analogous measurement and detection of the Morphine in the main sample are performed.Type: GrantFiled: July 7, 2008Date of Patent: March 26, 2013Assignee: Nartest International ASInventors: Sergey Babichenko, Tatjana Ivkina, Larisa Poryvkina, Vitaly Sominsky
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Patent number: 8394637Abstract: The invention relates to a handheld analyzer for testing a sample, in particular of a biological fluid, for a medically significant component. It comprises a test unit, which detects the correct positioning of an analytical consumable means in a conveyance pathway. According to this invention, the test unit has both an electric switch component which mechanically senses the positioning of the analytical consumable means and an optical sensor unit which optically senses the positioning of the analytical consumable means on the conveyance pathway. The handheld analyzer is controlled as a function of a comparison of the signals of the electric switch component and the optical sensor unit. It is possible in this way to reduce malfunctions or operating errors associated therewith.Type: GrantFiled: June 2, 2008Date of Patent: March 12, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Jochen Schulat, Gertrud Albrecht, Bernhard Kern
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Patent number: 8383416Abstract: An optical sensor and method for use with a visible-light laser excitation beam and a Raman spectroscopy detector, for detecting the presence chemical groups in an analyte applied to the sensor are disclosed. The sensor includes a substrate, a plasmon resonance mirror formed on a sensor surface of the substrate, a plasmon resonance particle layer disposed over the mirror, and an optically transparent dielectric layer about 2-40 nm thick separating the mirror and particle layer. The particle layer is composed of a periodic array of plasmon resonance particles having (i) a coating effective to binding analyte molecules, (ii) substantially uniform particle sizes and shapes in a selected size range between 50-200 nm (ii) a regular periodic particle-to-particle spacing less than the wavelength of the laser excitation beam. The device is capable of detecting analyte with an amplification factor of up to 1012-1014, allowing detection of single analyte molecules.Type: GrantFiled: January 10, 2012Date of Patent: February 26, 2013Assignee: Vladimir PoponinInventor: Vladimir Poponin
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Patent number: 8377705Abstract: A breath analyzer system and method for determining an estimate of blood alcohol concentration of a person. A light source projects light into a sampling region where breath from the person is expected. A first light detector and a second light detector are configured to detect light intensity of light having certain wavelengths at a first time and a second time. Signals from the light detectors at the first time and the second time are used to determine an estimate of the blood alcohol concentration of the person by determining a ratio of a first light detector signal change to a second light detector signal change.Type: GrantFiled: January 15, 2010Date of Patent: February 19, 2013Assignee: Delphi Technologies, Inc.Inventors: David K. Lambert, Michel F. Sultan
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Patent number: 8377711Abstract: The invention is directed to a system and method for detecting substances, such as explosives and/or drugs, using, in part, short bursts of energy light from a relatively low energy strobe. Embodiments include coupling the strobe with a detector for use in a portable hand-held unit, or a unit capable of being carried as a backpack. Embodiments further include placement of one or more stroboscopic desorption units and detectors in luggage conveyors systems, carry-on X-ray machines, and check-in counter locations. Embodiments further comprise the use of a strobe or another energy source to assist in maintaining the integrity of a SERS substrate surface operatively associated with the detector system, wherein the SERS substrate may be positioned in hand wand spaced apart from at least a portion of the detector. In another embodiment, the Raman excitation source may be located directly in the hand wand of a portable stroboscopic detection system.Type: GrantFiled: April 4, 2006Date of Patent: February 19, 2013Assignee: ADA Technologies, Inc.Inventors: Kent D. Henry, John Stanley Lovell
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Patent number: 8367420Abstract: The present invention relates to a method of detecting soil nutrients or soil nutrients in soil from reflected light, and also includes systems for the measurement, calculation and transmission of data relating to or carrying out that method.Type: GrantFiled: February 8, 2010Date of Patent: February 5, 2013Assignee: Bowling Green State UniversityInventors: B. B. Maruthi Sridhar, Robert K. Vincent
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Patent number: 8361805Abstract: A method, system and apparatus for an automated sample introduction system, utilizing a demountable direct injection high efficiency nebulizer (d-DIHEN) is provided which incorporates an inductively coupled plasma optical emission spectrometer (ICP-OES) for the measurement of the phosphorus content in acid-digested nucleotides and deoxyribonucleic acid (DNA). An external pulse-free peristaltic pump provides samples from a container via a probe, and the pump is stopped when the probe is removed from the container.Type: GrantFiled: March 10, 2010Date of Patent: January 29, 2013Inventors: Ryan G. Brennan, Savelas A. Rabb
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Publication number: 20130017619Abstract: Disclosed herein are methods for the detection and/or quantification of anionic surfactants. Also disclosed herein are test kits, which utilize the disclosed methods, to estimate the anionic surfactant concentration in samples, such as environmentally-derived samples. In some specific embodiments, the method and the test kit may be used to detect, among other things, aqueous film forming foams that comprise anionic surfactants.Type: ApplicationFiled: September 19, 2012Publication date: January 17, 2013Inventors: Megharaj Mallavarapu, Ravendra Naidu, Philip Mercurio
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Publication number: 20130017611Abstract: A method for fabricating a sensor material for detecting molecular contaminants, including the steps of: providing an aqueous solution of a metal oxide precursor; mixing titanium dioxide nanotubes with the aqueous solution of the metal oxide to form a mixture; adjusting a pH value of the mixture with a weak base until the pH value is neutral; dispersing the mixture in water and heating the mixture; and filtering the mixture to retain a solid part, and calcining the solid part under a continuous flow of oxygen to form metal oxide loaded titanium dioxide nanotubes. The disclosure also provides a sensor material and a detecting method using the sensor material for ppm-ppb-ppt concentration level detection of molecular contaminants.Type: ApplicationFiled: November 28, 2011Publication date: January 17, 2013Inventors: Shou-Nan LI, Hong-Ping LIN, Hui-Ya SHIH, Wen-An HSIEH, Jhih-Jie LIN
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Patent number: 8354073Abstract: The present invention provides an inspection chip using light, which is able to provide an irradiation of light at a high precision. The present invention further provides an inspection chip capable of carrying out the inspection of a sample in a simple manner by using a plurality of lights. The inspection chip of the present invention comprises a light amplifier element and a sample holding section for holding a sample, in which the light amplifier element is oriented so as to face to the sample holding section, so that the light emitted from the light amplifier element can irradiate the sample held in the sample holding section.Type: GrantFiled: May 23, 2005Date of Patent: January 15, 2013Assignee: Kyushu University, National University CorporationInventors: Yuji Oki, Satoru Kuhara
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Patent number: 8349757Abstract: The invention provides an electrode comprising an electrically conductive material having a surface capable of producing surface enhanced Raman scattering of incident light from a complex adsorbed at the surface of the electrode, the complex including the electrically conductive material combined with a second material that is substantially reducible and not substantially oxidizable. The surface of the electrode can be microroughened. The invention also includes a method for making various embodiments of the electrode, and a method of generating electricity using the electrode. In accordance with a further aspect of the invention, a fuel cell is provided including the electrode of the invention.Type: GrantFiled: March 14, 2011Date of Patent: January 8, 2013Assignee: Fordham UniversityInventor: John J. McMahon
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Patent number: 8330951Abstract: Packaged NERS-active structures are disclosed that include a NERS substrate having a NERS-active structure thereon, and a packaging substrate over the NERS substrate having an opening therethrough, the opening in alignment with the NERS-active structure. A membrane may cover the opening in the packaging substrate. In order to perform nanoenhanced Raman spectroscopy, the membrane may be removed, and an analyte placed on the NERS substrate adjacent the NERS-active structure. The membrane may be replaced with another membrane after the analyte has been placed on the substrate. The membrane may maintain the pristine state of the substrate before it is deployed, and the replacement membrane may preserve the substrate and analyte for archival purposes. Also disclosed are methods for performing NERS with packaged NERS-active structures.Type: GrantFiled: April 28, 2006Date of Patent: December 11, 2012Assignee: Hewlett-Packard Development Company, L.P.Inventors: Zhiyong Li, William M. Tong, R. Stanley Williams
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Patent number: 8309897Abstract: A method and device for enhancing the power correction of optical measurements in an optical measurement arrangement, the steps including: providing a light source for producing a light beam; splitting the light beam into two beams; directing a first split light beam through an interrogation area and into an optics separation device; directing the light beams from the optics separation device and a second split light beam representing the intensity of the illumination of the main light beam of the light source into cells of a detector array; measuring and assessing the information obtained in the cells; and using this information to calculate the corrected value for the cells receiving the light beams from the optics separation device in order to adjust the power for the intensity of the light beam of the light source and/or to correct the intensity of the light beams from the interrogation area.Type: GrantFiled: February 1, 2010Date of Patent: November 13, 2012Assignee: Pocared Diagnostics Ltd.Inventor: Gal Ingber
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Publication number: 20120282630Abstract: The present invention provides for mixed metal structures that can be deposited on a substrate or free in solution that exhibit several distinctive properties including a broad wavelength range for enhancing fluorescence signatures. Further, metal surface plasmons can couple and such diphase coupled luminescence signatures create extra plasmon absorption bands. The extra bands allow for a broad range of fluorophores to couple therefore making more generic substrates with wider reaching applications.Type: ApplicationFiled: December 17, 2010Publication date: November 8, 2012Inventor: Chris D. Geddes
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Patent number: 8304251Abstract: Systems and methods are disclosed to automatically detect the presence of a substance on a test swipe by capturing a background image of the test swipe; applying one or more test chemicals to a test swipe; adjusting the temperature of the test swipe to a predetermined temperature range; capturing an in-situ image of the test swipe after the application of chemical at the predetermined temperature range; subtracting the background image from the in-situ image; generating a difference value from the two images; and searching a known database to identify the substance.Type: GrantFiled: February 18, 2009Date of Patent: November 6, 2012Assignee: Chem Spectra, Inc.Inventors: Jeffrey Haas, Douglas Haas
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Publication number: 20120264225Abstract: A method for controlling a hazardous element in an encapsulating resin of a resin encapsulation semiconductor device includes subjecting the device to qualitative analysis with a fluorescent X-ray analyzer to judge whether the hazardous element is contained in the encapsulating resin, aligning a plurality of devices with each of upper and lower surfaces of the devices brought into a plane, setting the surfaces of the devices to cover a full X-ray irradiation plane and subjecting the devices to quantitative analysis with the fluorescent X-ray analyzer to obtain an analytical value of the hazardous element in the encapsulating resin for upper and lower surfaces of the devices, and judging whether the analytical value of the hazardous element which is less influenced by a coexistent element of the analytical values for the upper and lower surfaces of the devices exceeds a threshold value.Type: ApplicationFiled: June 14, 2012Publication date: October 18, 2012Inventors: Mitsuhiro OKI, Miyuki TAKENAKA
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Patent number: 8268249Abstract: An analytical cell including a lightguide with a plurality of conduits filled with a migration medium. The medium, the lightguide and a surrounding medium have refractive indices selected such that light entering the lightguide is internally reflected within the lightguide to provide substantially uniform illumination of the conduits.Type: GrantFiled: November 16, 2006Date of Patent: September 18, 2012Assignees: 3M Innovative Properties Company, Life Technologies CorporationInventors: Larry J. Carson, Joel R. Dufresne, Patrick R. Fleming, Michael C. Lea, Nicholas A. Lee, John Shigeura
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Patent number: 8268571Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.Type: GrantFiled: August 11, 2011Date of Patent: September 18, 2012Assignee: STC.UNMInventors: Larry A Sklar, Bruce Edwards, Frederick Kuckuck
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Patent number: 8268624Abstract: A system and method of characterizing an at least partially hydrophobic sample. The method includes providing an ethanolic solution of ethanol and sodium hydrogen cyanamide, adding a first portion of the ethanolic solution to a sample to produce a reagent-sample mixture, performing infrared spectroscopic testing of the reagent-sample mixture to generate mixture absorption data representing at least one absorption characteristic of the reagent-sample mixture, and generating acidity data for the sample based on the mixture data.Type: GrantFiled: April 29, 2010Date of Patent: September 18, 2012Assignee: Thermal-Lube, Inc.Inventors: Frederick R. van de Voort, David Pinchuk
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Patent number: 8268628Abstract: The invention describes a method for determining aggregation in protein, peptide or peptoid formulation, without the use of probes or additives. The method uses FTIR spectroscopy combined with the two-dimensional correlation analysis (2DCOS) which allows for the determination of the presence of aggregates, the determination of the mechanism of aggregation, allowing for correction in the pipeline manufacturing process of the protein to once again generate viable protein. In addition, the thermal transition of the protein can also be determined and a 2DCOS plot generated to compare with the established viable protein, allowing for quality control, stability and viability of the desired protein product. The ease of sample preparation and data analysis allows for the automation of this method.Type: GrantFiled: April 14, 2008Date of Patent: September 18, 2012Assignee: University of Puerto RicoInventors: Belinda Pastrana-Rios, Ibon LLoro-Manzano
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Patent number: 8264680Abstract: A biochip reader wherein spectroscopic information of a sample under analysis is arranged in spaces between images of the sample arranged on a biochip. The reader comprises a confocal microscope and the biochip comprises a transparent substrate to allow passage of the excitation light and fluorescent light from the sample with the excitation light being applied from the side opposite that on which the samples are arranged so that noise from dust and the like is avoided by the transmitted light avoiding contact with the dust. Another aspect is an electrophoresis system wherein different coloring material are used for each of a variety of target substances, so that the same lane and area are utilizable to concurrently detect a polychrome fluorescent pattern of the different targets. A confocal scanner or fluorescence imaging system is used with a plurality of filters to detect the multi-colored fluorescences of the target substance.Type: GrantFiled: August 28, 2009Date of Patent: September 11, 2012Assignee: Yokogawa Electric CorporationInventor: Takeo Tanaami
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Publication number: 20120225021Abstract: In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.Type: ApplicationFiled: March 2, 2011Publication date: September 6, 2012Inventors: Wei QIAN, Makoto MURAKAMI, Yuki ICHIKAWA, Yong CHE
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Patent number: 8232104Abstract: One embodiment of the disclosure relates to a detection system including a chemical taggant and a detector. The chemical taggant may be a chemical not substantially present in an untagged target exhaust plume and able to be disposed in the exhaust system of a target and to enter the exhaust plume of the exhaust system in detectable quantities. The chemical taggant may have one or more distinct energy signatures, such as optical energy signatures, that allow its detection. The detector may be able to detect at least one of these one or more energy signatures of the chemical taggant in the exhaust plume. Another embodiment relates to a method of detecting a target by disposing a chemical taggant in the exhaust system of the target and then detecting the chemical taggant.Type: GrantFiled: May 7, 2009Date of Patent: July 31, 2012Assignee: Raytheon CompanyInventor: Gary A. Frazier
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Patent number: 8227256Abstract: Two-color (two-photon) excitation with two confocal excitation beams is demonstrated with a Raman shifter as excitation light source. Two-color excitation fluorescence is obtained from Coumarin 6H dye sample (peak absorption=394 nm, peak fluorescence=490 nm) that is excited using the first two Stokes outputs (683 nm, 954 nm, two-color excitation=398 nm) of a Raman shifter pumped by a 6.5 nsec pulsed 532 nm-Nd:YAG laser (Repetition rate=10 Hz). The two Stokes pulses overlap for a few nanoseconds and two-color fluorescence is generateven with focusing objectives of low numerical apertures (NA?0.4). We observed the linear dependence of the two-color fluorescence signal with the product of the average intensities of the two Stokes excitation beams. The two-color fluorescence distribution is strongly localized around the common focus of the confocal excitation beams.Type: GrantFiled: September 27, 2002Date of Patent: July 24, 2012Inventors: Caesar A. Saloma, Wilson O. Garcia, Jonathan A. Palero
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Patent number: 8211707Abstract: The stress measuring method of the present claimed invention includes an external force impressing process that applies an external force to a specimen, an electron beam irradiating process that irradiates an electron beam to the specimen, a spectroscopy process that conducts spectroscopy on light generated from the specimen by the above-mentioned electron beam irradiating process so as to obtain a spectrum, and a stress calculating process that obtains a stress based on a spectrum shift between a specimen spectrum obtained by irradiating the electron beam on the above-mentioned specimen and a stress impressed spectrum obtained by irradiating the electron beam on the specimen in a state that a stress exists due to the above-mentioned external impressing process.Type: GrantFiled: March 13, 2003Date of Patent: July 3, 2012Inventor: Giuseppe Pezzotti
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Patent number: 8211708Abstract: The light measurement apparatus of the invention, in which the light is irradiated to the sample dispersed in the liquid flowing through the flow passage, is used for measuring optical information of the sample. The apparatus includes a light source portion 20 for irradiating the irradiating light L to the liquid 11, a light receiving portion 31 to receive the optical information of the sample S including the irradiating light transmitted through the liquid to generate a receiving light signal SG1, under a condition in which the liquid is irradiated by the irradiating light of the light source portion 20 in a state that a relative position of the sample S to the irradiating light varies at constant speed, a measurement portion 120 for measuring variation of the receiving light signal according to the sample.Type: GrantFiled: November 2, 2009Date of Patent: July 3, 2012Assignee: Furukawa Electric Co., Ltd.Inventors: Ken Tsukii, Toru Takahashi, Shinichi Taguchi, Jie Xu
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Publication number: 20120135536Abstract: A sensor for use in detecting and analyzing predetermined chemical substances is presented.Type: ApplicationFiled: November 28, 2011Publication date: May 31, 2012Applicant: YEDA RESEARCH & DEVELOPMENT CO., LTD.Inventors: Israel Rubinstein, Alexander Vaskevich, Gregory Kalyuzhny
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Patent number: 8183052Abstract: Methods and apparatus for testing the sterility of a product to be administered to a patient. The sterility of the product is tested by monitoring the pH change of a culture medium in contact with any culturable organisms (e.g., bacteria) that are collected by filtration of the product to be tested.Type: GrantFiled: June 8, 2009Date of Patent: May 22, 2012Assignee: Blood Cell Storage, Inc.Inventors: Michael W. Reed, Lynn M. Barker, Evert Jan Klip
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Detection of lysophosphatidylcholine for prognosis or diagnosis of a systemic inflammatory condition
Patent number: 8183050Abstract: The present invention provides methods and compositions useful for the diagnosis or prognosis of a systemic inflammatory condition such as sepsis.Type: GrantFiled: September 28, 2006Date of Patent: May 22, 2012Assignee: Becton, Dickinson and CompanyInventors: Song Shi, Thomas Gentle, Richard Moore -
Patent number: 8178355Abstract: The present invention relates to the field of detection of components in gas phase, and in particular to detection of nitric oxide exhaled as a component of breath, using a liquid crystal assay format and a device utilizing liquid crystals as part of a reporting system.Type: GrantFiled: September 15, 2009Date of Patent: May 15, 2012Assignee: Platypus Technologies, LLC.Inventors: Bharat Acharya, Avijit Sen, Nicholas Abbott, Kurt Kupcho
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Publication number: 20120115239Abstract: Vapochromic coordination polymers useful for analyte detection are provided. The vapochromism may be observed by visible color changes, changes in luminescence, and/or spectroscopic changes in the infrared (IR) signature. One or more of the above chromatic changes may be relied upon to identify a specific analyte, such as a volatile organic compound or a gas. The chromatic changes may be reversible to allow for successive analysis of different analytes. The polymer has the general formula MW[M?X(Z)Y]N wherein M and M? are the same or different metals capable of forming a coordinate complex with the Z moiety; Z is selected from the group consisting of halides, pseudohalides, thiolates, alkoxides and amides; W is between 1-6; X and Y are between 1-9; and N is between 1-5. One embodiment provides [Metal(CN)2]-based coordination polymers with vapochromic properties, such as Cu[Au(CN)2]2 and Zn[Au(CN)2]2 polymers.Type: ApplicationFiled: October 21, 2011Publication date: May 10, 2012Inventors: Julie LEFEBVRE, Michael Iacov KATZ, Daniel B. LEZNOFF
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Patent number: 8175371Abstract: Provided are methods for determining and analyzing photometric and morphogenic features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: July 26, 2011Date of Patent: May 8, 2012Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael E. Seo, Phillip J. Morrissey, Cathleen A. Zimmerman
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Patent number: 8169695Abstract: An imaging method and system are presented for use in sub-wavelength super resolution imaging of a subject. The imaging system comprises a spatial coding unit configured for collecting light coming from the scanned subject and being spaced from the subject a distance smaller than a wavelength range of said light; a light detection unit located upstream of the spatial coding unit with respect to light propagation from the object, and configured to define a pixel array and a spatial decoding unit, which is associated with said pixel array and is configured for applying spatial decoding to a magnified image of the scanned subject, thereby producing nanometric spatial resolution of the image.Type: GrantFiled: November 10, 2008Date of Patent: May 1, 2012Assignee: Xceed Imaging Ltd.Inventor: Zeev Zalevsky
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Publication number: 20120100629Abstract: The invention relates to a device for investigating reactions between interactive species, said device comprising: one or more plasma deposited layers, which layers comprise one or more first pre-selected functional group species, which functional group species are interactible with a pre-selectable second species.Type: ApplicationFiled: September 28, 2011Publication date: April 26, 2012Applicant: Holland Biomaterials Group B.V.Inventors: Johannes Gijsbertus Antonius Terlingen, Gerardus Henricus Maria Engbers
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Patent number: 8163278Abstract: A method of determining the efficacy of secretin, neuropeptides, peptides, and/or digestive enzymes for treatment of an individual diagnosed with a pervasive development disorder, such as autism, where the individual has an abnormal fecal chymotrypsin level and exhibits a lack of protein digestion. A sample of feces is obtained from the individual in order to determine a quantitative level of chymotrypsin in the sample. The quantitative level of chymotrypsin is used to determine the efficacy of treating the individual with secretin, neuropeptides, peptides, and/or digestive enzymes. If it is determined, based on the individual's fecal chymotrypsin level, that the individual would benefit from the administration of secretin, neuropeptides, peptides, and/or digestive enzymes, then the amount necessary to effect a change in the individual's autistic behavior is determined by the individual's fecal chymotrypsin level, age and weight.Type: GrantFiled: October 8, 2003Date of Patent: April 24, 2012Assignee: Curemark LLCInventor: Joan M. Fallon
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Patent number: 8153438Abstract: This invention relates to using an electron microscope to sequence by direct inspection of labeled, stretched DNA. This method will have higher accuracy, lower cost, and longer read length than current DNA sequencing methods.Type: GrantFiled: April 2, 2010Date of Patent: April 10, 2012Assignee: Halcyon MolecularInventors: William Andregg, Michael Andregg
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Patent number: 8143070Abstract: A use composition monitor determines the concentration of peracid and/or peroxide in a use composition using a kinetic assay procedure. A sample mixture containing a sample of the use composition, a diluent and at least one reagent is prepared and analyzed using, for example, an optical detector. A reduced-turbulence optical detector can be used to improve collected response data. A reduced-turbulence optical detector can include a cell body disposed about a length of transparent tubing. The cell body positions one or more emitter/receiver pairs about the transparent tubing. Thus, tube junctions are eliminated and sample flow within the tube is substantially turbulence free.Type: GrantFiled: February 12, 2009Date of Patent: March 27, 2012Assignee: Ecolab USA Inc.Inventors: Eugene Tokhtuev, Christopher Owen, Anna Pilipchenko, Paul Schilling, Daniel Kamben
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Publication number: 20120070362Abstract: A method for quantitatively monitoring gas phase materials in a chemical process is provided and includes, providing a gaseous feed stream containing one or more reactant gases of interest; exposing the gaseous feed stream to coherent radiation from a Raman spectroscopic device; acquiring a Raman spectroscopic signal from each of the gaseous components in the feed stream; analyzing the spectroscopic signal to determine the presence and concentration of each of the gaseous components; and displaying the results of the analysis. In one embodiment, the method is useful for quantitatively monitoring gas phase materials in a process for making high purity silicon.Type: ApplicationFiled: May 11, 2010Publication date: March 22, 2012Applicants: HEMLOCK SEMICONDUCTOR CORPORATION, DOW CORNING CORPORATIONInventors: Greg Harms, Douglas Kreszowski, David Licht, Elmer Lipp, Michael Molnar, Marc Pinet
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Patent number: 8119412Abstract: A use composition monitor determines the concentration of peracid and/or peroxide in a use composition using a kinetic assay procedure. A sample mixture containing a sample of the use composition, a diluent and at least one reagent is prepared and analyzed using, for example, an optical detector. Response data obtained by the detector is indicative of the optical absorbance of the sample mixture as a function of time. A processor analyzes the response data to determine a corresponding best fit linear relationship. The initial absorbance of the sample mixture is indicative of the concentration of peracid in the use composition, while the slope of the best fit equation is indicative of the concentration of peroxide in the use composition.Type: GrantFiled: June 5, 2007Date of Patent: February 21, 2012Assignee: Ecolab USA Inc.Inventor: Paul R. Kraus
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Patent number: 8119417Abstract: Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer patient, head and neck squamous cell carcinoma or colorectal cancer patient has likely developed a non-responsiveness to treatment with a drug targeting an epidermal growth factor receptor pathway. As the methods of this disclosure require only simple blood samples, the methods enable a fast and non-intrusive way of measuring when drugs targeting the EGFR pathway cease to be effective in certain patients. This discovery represents the first known example of true personalized selection of these types of cancer patients for treatment using these classes of drugs not only initially, but during the course of treatment.Type: GrantFiled: January 27, 2011Date of Patent: February 21, 2012Assignee: Biodesix, Inc.Inventors: Heinrich Röder, Maxim Tsypin, Julia Grigorieva
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Patent number: 8119418Abstract: Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer patient, head and neck squamous cell carcinoma or colorectal cancer patient has likely developed a non-responsiveness to treatment with a drug targeting an epidermal growth factor receptor pathway. As the methods of this disclosure require only simple blood samples, the methods enable a fast and non-intrusive way of measuring when drugs targeting the EGFR pathway cease to be effective in certain patients. This discovery represents the first known example of true personalized selection of these types of cancer patients for treatment using these classes of drugs not only initially, but during the course of treatment.Type: GrantFiled: January 27, 2011Date of Patent: February 21, 2012Assignee: Biodesix, Inc.Inventors: Heinrich Röder, Maxim Tsypin, Julia Grigorieva
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Patent number: 8119415Abstract: Process of placing a sample of known concentrations of known elements in a spectrometer; measuring the intensity II, I2 . . . In of the different elements included in the sample, by relating known concentrations C1, C2 . . . Cn for the elements included in the sample to the measured intensities II, I2 . . . In so as to calculate a fictive intensity for a 100%-pure element for each of the elements included; calculating calibration constants K1, K2 . . . Kn for each of the elements as the relationship between measured intensity II, I2 . . . In and the calculated intensity of respective 100%-pure elements; placing a sample of unknown concentrations of the elements in the spectrometer and reading-off the intensity of the different elements; and calculating the concentration of respective elements in the last mentioned sample as the measured intensity multiplied by respective calibration constants for the elements present in the sample.Type: GrantFiled: April 17, 2007Date of Patent: February 21, 2012Assignee: Multiscat ABInventors: Lars Kumbrandt, Johan Malmqvist
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Patent number: 8119066Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The cartridge has one or more light sources and/or optical systems and other components that are specific for a certain type of application such as fluorescence, absorbance, or luminescence. The light source, optical systems, and other components for a specific application are housed in a single cartridge. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with the apparatus in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed.Type: GrantFiled: February 8, 2006Date of Patent: February 21, 2012Assignee: Molecular Devices, LLCInventors: Daniel M. Stock, Josef J. Atzler
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Patent number: 8119407Abstract: What is described is a single reference material and method of making useful for calibrating or qualifying instruments that are diagnostic spectroscopically for bilirubin, hemoglobin, and hemoglobin fractions, and, optionally, diagnostic for other blood analytes by sensor means.Type: GrantFiled: April 29, 2009Date of Patent: February 21, 2012Assignee: Instrumentation Laboratory CompanyInventors: Michael Pistorino, Prasad Pamidi
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Patent number: 8105584Abstract: A method of utilizing the chymotrypsin level of an individual as a measure of the success of secretin, other neuropeptides, and peptides or digestive enzyme administration to such individuals, and in particular, as a prognosticative of potential secretin, other neuropeptides, peptides, and digestive enzyme administration for persons having ADD, ADHD, Autism and other PDD related disorders. In one aspect, a method for determining the efficacy of secretin, other neuropeptides, peptides, or digestive enzymes for the treatment of an individual diagnosed with a pervasive developmental disorder (PDD) comprises obtaining a sample of feces from an individual, determining a quantitative level of chymotrypsin present in the sample, and correlating the quantitative level of chymotrypsin determined to be present in the sample with the PDD to determine the efficacy of treating the individual with secretin, other neuropeptides, peptides, or digestive enzyme administration.Type: GrantFiled: September 8, 2008Date of Patent: January 31, 2012Assignee: Curemark LLCInventor: Joan M. Fallon
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Patent number: 8103080Abstract: Provided are methods for determining and analyzing photometric and morphogenic features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: March 16, 2005Date of Patent: January 24, 2012Assignee: Amnis CorporationInventors: Thaddeus C George, David A Basiji, Brian E Hall, William E Ortyn, Michael J Seo, Philip J Morrissey, Cathleen A Zimmerman