Stabilizing Or Preserving Patents (Class 436/176)
  • Patent number: 10428830
    Abstract: An impeller includes a hub and a plurality of blades. The blades are connected with the hub. Each blade includes a base part connected with the hub and a tip part opposed to the base part. The thickness of the tip part of the blade is greater than that of the base part of the blade. In addition, an airflow-guiding part is disposed at the tip part of the blade.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: October 1, 2019
    Assignee: DELTA ELECTRONICS, INC.
    Inventors: Chin-Hung Lee, Tsung-Yin Lee
  • Patent number: 9063041
    Abstract: A method of drying a biological sample disposed on a substrate is provided. The method comprises providing the substrate comprising a sample loading area and a heat source; activating the heat source for generating heat; heating the substrate at least above 65° C.; and drying the biological sample. A device for storing sample is also provided, wherein the device comprises a substrate for biological sample-storage; and a heating component that generates heat to maintain a temperature of at least above 65° C. The heating component may contain one or more reagents, wherein the reagents generate heat to maintain a temperature of at least above 65° C.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: June 23, 2015
    Assignee: General Electric Company
    Inventors: Christopher Michael Puleo, John Richard Nelson, Patrick McCoy Spooner, Ralf Lenigk
  • Patent number: 9040255
    Abstract: The present invention provides methods for preventing clumping of cells in microfluidic devices by addition of diazolidinyl urea (DU). DU can be added to samples at the time of collection or can be added to samples post-collection. DU can also be pre-added to sample collection devices.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: May 26, 2015
    Assignee: BIOCEPT, INC.
    Inventors: Pavel Tsinberg, Stephen D. Mikolajczyk
  • Publication number: 20150093837
    Abstract: A method for the storage of biological samples is disclosed. The method includes the steps of coupling a storage device to a biological sample collection apparatus capable of collecting a biological sample from a subject, introducing a biological sample from the biological sample collection apparatus to the storage device, and drying the biological sample on the storage device. In another embodiment, the storage device used by the method may include a collection medium having a top surface, a bottom surface, and a predetermined size and shape, the top surface comprising a position marker and at least one binding site operable to bind a biological sample; and a protective facing substantially impermeable to the biological sample, the protective facing coupled to the top surface of the collection medium and having a size and shape substantially similar to the predetermined size and shape of the collection medium.
    Type: Application
    Filed: December 8, 2014
    Publication date: April 2, 2015
    Inventors: James M. Hampsch, Scott R. Peters
  • Patent number: 8993333
    Abstract: Disclosed is a method of providing a risk evaluation and diagnosis of human cancer, by examining the presence, in the volatile fraction of a human saliva sample, of a combination of particulate biochemical volatile organic compounds, which is indicative of an increased risk of developing cancer.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: March 31, 2015
    Assignee: Institut Clinident
    Inventor: Franck Chaubron
  • Patent number: 8975039
    Abstract: Provided is a system and method for staining of one or more samples, including providing one or more self-contained sample processing receptacles, each of the one or more self-contained sample processing receptacles configured to be inserted into an auto-staining instrument; and enabling one of one or more staining procedures appropriate for the one or more samples as a function of a choice of self-contained sample processing receptacle, each of the one or more self-contained sample processing receptacles configured to process each inserted sample of the one or more samples within the self-contained sample processing receptacle.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: March 10, 2015
    Assignee: SYFR, Inc.
    Inventors: Shazi Iqbal, Steven M. Montgomery, Ronald Chang, Gregory Mote, Douglas B Dority, Jeffrey S. Ross
  • Publication number: 20150056716
    Abstract: A sample collection device having a sample tube, funnel, and cap having a capsule and a piercing insert, the capsule having a stabilization solution. After depositing the sample into the tube via the funnel, the cap is screwed onto the tube, piercing the capsule and releasing the stabilization fluid into the tube. The device can be used at home without clinicial supervision for collecting a saliva sample and transporting the sample to an analysis location for DNA analysis.
    Type: Application
    Filed: July 31, 2014
    Publication date: February 26, 2015
    Inventors: Benjamin J. Oyler, Kenneth G. Chahine, Catherine Ann Ball, Federico C.A. Gaeta
  • Publication number: 20140342466
    Abstract: Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range.
    Type: Application
    Filed: May 28, 2014
    Publication date: November 20, 2014
    Applicants: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Mauro FERRARI, Mark Ming-Cheng CHENG
  • Publication number: 20140329705
    Abstract: Provided herein is an all-in-one saliva collection apparatus that collects saliva to allow for the filtration of saliva in order to separate saliva components, such as extracellular proteins and nucleic acids that are not present in intact cells, from the intact cells and debris remaining in the extracted sample. The filtered saliva samples can be aliquoted into two fractions for protein and/or nucleic acid analysis. The present invention further describes long term storage at ambient temperatures of filtered salivary nucleic acids, and long term storage at ambient temperatures of filtered salivary proteins added to an ethanol solution. The filtered cell-free saliva samples have diagnostic usefulness.
    Type: Application
    Filed: August 6, 2012
    Publication date: November 6, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALFORNIA
    Inventors: David T. Wong, Wei Liao
  • Patent number: 8802424
    Abstract: Methods, systems and their components for monitoring fluorescent signals and particularly transient fluorescent signals from reaction mixtures of interest, which methods and systems employ modulated excitation light sources to reduce impacts of excessive illumination on the reaction components or the data obtained therefrom.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: August 12, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Khai Luong, Paul Lundquist, Ravi Dalal, John Lyle, Stephen Turner
  • Patent number: 8796028
    Abstract: The invention relates to a method for treating a biological sample, comprising the following method steps: i) preparation of a biological sample and ii) bringing the biological sample into contact with a composition, comprising: (1) 1 to 100 wt. % of at least one polyol and (2) 0 to 99 wt. % of at least one additive, wherein the total amount of components (1) and (2) is 100 wt. %. The invention further relates to biological samples obtained by said method, a method for analysis of a treated biological sample, devices for treating a biological sample, use of said devices, various kits and use of a composition.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: August 5, 2014
    Assignee: Qiagen GmbH
    Inventor: Vera Holländer
  • Patent number: 8790932
    Abstract: A method for providing a dried reagent in a microfluidic system is provided, the method comprising the following steps: providing a microfluidic system having a microfluidic structure, introducing a flowable carrier medium containing a reagent in the microfluidic structure, and drying the reagent in the microfluidic structure by lyophilization.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: July 29, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Manfred Augstein, Romi Roedl, Susanne Wuerl, Valerie Winckler-Desprez
  • Patent number: 8765485
    Abstract: Various aspects of the present invention relates to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid, etc. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles, etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: July 1, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: Darren Roy Link, David A. Weitz, Galder Cristobal-Azkarate, Zhengdong Cheng, Keunho Ahn
  • Patent number: 8765476
    Abstract: Automated sample processing systems may include onboard efficient high-speed mixing of at least two components with an automatic vertical force fluidic turbulent component mixer of which a mixed component may be aspirated and high-speed dispensed in a mixing vial. Other aspects may include single sweep applying a multi-treatment cleaning cycle to at least one slide. A multi-treatment cleaning cycle may include a washing treatment and a drying treatment. In yet other aspects the present invention may include an automated recovery sample processing system with the capability of detecting at least one immediate condition of a fortuitously terminated automatic sample processing run and perhaps even an automatic terminated sample processing run reconstruction calculator.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: July 1, 2014
    Assignee: Biocare Medical, LLC
    Inventors: Saradha Avantsa, Ravishankar Melkote, Thomas Maxwell, Geoffrey Cook
  • Patent number: 8748188
    Abstract: Chlorine dioxide solutions are stabilized and prepared for storage, transportation, and testing. Each solution is separated into two samples. Chlorine dioxide is removed from one sample and then each sample is stabilized and prepared such that each sample contains only oxidized and/or reduced forms of chlorine dioxide. The stable samples may be stored, transported, and tested for chlorine dioxide. The samples are tested for the oxidized and/or reduced forms of chlorine dioxide by known methods, and mass balance equations are used to determine the concentration of chlorine dioxide in the original sample before stabilization and preparation.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: June 10, 2014
    Inventors: Allison H. Sampson, Richard L. Sampson, George Dimotsis
  • Publication number: 20140154736
    Abstract: A method of drying a biological sample disposed on a substrate is provided. The method comprises providing the substrate comprising a sample loading area and a heat source; activating the heat source for generating heat; heating the substrate at least above 65° C.; and drying the biological sample. A device for storing sample is also provided, wherein the device comprises a substrate for biological sample-storage; and a heating component that generates heat to maintain a temperature of at least above 65° C. The heating component may contain one or more reagents, wherein the reagents generate heat to maintain a temperature of at least above 65° C.
    Type: Application
    Filed: November 30, 2012
    Publication date: June 5, 2014
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Christopher Michael Puleo, John Richard Nelson, Patrick McCoy Spooner, Ralf Lenigk
  • Publication number: 20140134749
    Abstract: This invention concerns a sampling procedure for an aqueous hydrosoluble polymer solution flowing in a main circuit, enabling a sample to be collected to undergo at least one analysis under ambient air giving at least one property of the hydrosoluble polymer characterised in that a stabilizing solution is added to the aqueous hydrosoluble polymer solution, according to a discontinuous addition method, before or after sampling from the main circuit, so as to obtain a sample comprising a mixture of aqueous hydrosoluble polymer solution and stabilizing solution in which the hydrosoluble polymer is protected against attacks it may undergo in an atmosphere containing at least 10% by volume of oxygen.
    Type: Application
    Filed: July 2, 2012
    Publication date: May 15, 2014
    Applicant: S.P.C.M. SA
    Inventor: Cedrick Favero
  • Patent number: 8709824
    Abstract: The present invention concerns a contamination barrier 5 that permits an efficient and reproducible processing of a high number of samples with the prevention of contamination of aqueous solutions 3 in open and/or automated systems, especially in the ppm range, in that it comprises at least one water immiscible hydrocarbon compound. In addition a method for the prevention of contamination during the processing of aqueous solutions 3 in open and/or automated systems is disclosed.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: April 29, 2014
    Assignee: Qiagen GmbH
    Inventors: Thomas Rothmann, Markus Sprenger-Haussels, Petra Benkel, Sabine Hermes, Friederike Wilmer
  • Patent number: 8703492
    Abstract: An automated sample processing system having a sample input adapted to simultaneously receive a number of sample containers, a reagent input adapted to receive one or more new reagent supplies, a consumable input adapted to receive one or more new consumable supplies, a solid waste output adapted to receive used consumable supplies, a liquid waste output adapted to receive one or more used reagent supplies, and a processing center. The processing center includes a decapper adapted to remove a lid from at least one sample container, an aspirator adapted to remove a specimen from the at least one sample container and transfer the specimen to an output vessel, and a capper adapted to replace the lid on the at least one sample container.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: April 22, 2014
    Assignee: Qiagen Gaithersburg, Inc.
    Inventors: Brian Austin Self, Jonathan Matthew Miller, Carl Theodore Edens
  • Publication number: 20140011289
    Abstract: The invention relates to an arrangement for drying of biological samples on a sample storage substrate, comprising at least one sample storage substrate holder and at least one chemical heat pad.
    Type: Application
    Filed: March 15, 2012
    Publication date: January 9, 2014
    Applicant: GE HEALTH CARE UK LIIMITED
    Inventors: Michael John Smith, Stevan Paul Tortorella
  • Patent number: 8623658
    Abstract: A method of cryopreserving sperm cells which may include cooling the quantity of sperm cells to a holding temperature, maintaining the sperm cells substantially at the holding temperature for a period, and supercooling the sperm cells by cooling the sperm cells at a first cooling rate to a temperature that approaches a critical temperature zone at which ice crystal formation and changes in osmotic pressure damage sperm cells and then cooling the sperm at a second cooling rate faster than said first cooling rate through said critical temperature zone.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: January 7, 2014
    Assignee: Inguran, LLC
    Inventors: Jeffrey A. Graham, Cindy Ludwig, Muhammad Anzar, Kathleen S. Crowley, Bradley Didion, Gary Durack
  • Patent number: 8614095
    Abstract: Methods for the preparation of cell compositions based on fluorescence following excitation at wavelength of or about 488 nm and isolated cell compositions obtained therefrom wherein isolated cells exhibit (i) autofluorescence at or about 520 nm or (ii) absence of fluorescence at or about 520 nm and a positive shift in the fluorescence detected at >630 nm. These methods provide for enrichment of immature or stem cancer-initiating cells from tumors (notably, cancers of the central and peripheral nervous system and metastasis to the brain) and methods for screening antitumor agents using the same. Also provided are methods of detecting immature or stem cancer-initiating cells in a cell sample and methods of detecting recurrence of cancer stem cells in a cancer stem cell sample following treatment with an agent.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: December 24, 2013
    Assignees: Universite de Geneve, Hopitaux Universitaires de Geneve
    Inventors: Ivan Radovanovic, Virginie Clement
  • Patent number: 8592219
    Abstract: A method for transporting in a microfluidic conduit an aliquot of a liquid, possibly containing a substance I, which is dissolved in the liquid and typically exhibits charged groups and/or hydrophobic groups. The method is characterized in that the liquid contains an amphiphilic macromolecular substance.
    Type: Grant
    Filed: January 20, 2005
    Date of Patent: November 26, 2013
    Assignee: Gyros Patent AB
    Inventors: Rickard Kange, Mats Inganas, Magnus Gustafsson, Johan Engstrom, Bo Ek, Helene Dérand, Ann-Kristine Honerud
  • Patent number: 8586349
    Abstract: The present invention concerns a method for the detection of an analyte in a droplet of fluid comprising the steps of providing a solid phase with a hydrophobic surface comprising at least one capture zone on which at least one binding agent with affinity for the analyte is immobilized, applying said droplet to the surface of said solid phase, applying a force that makes the droplet travel along the surface of said solid phase along a predetermined path thereby allowing the droplet to repeatedly contact said binding agent on the capture zone, applying conditions wherein said analyte is allowed to bind to said binding agent and detecting a complex of analyte and binding reagent at the position of the capture zone. The effect of a moving droplet is that the reactants in the droplet are well mixed which eliminates the risk of diffusion limitation. Such advantageous mixing is not obtained with conventional assays in which the surface is continuously exposed to the liquid.
    Type: Grant
    Filed: August 6, 2001
    Date of Patent: November 19, 2013
    Assignee: Biomerieux B.V.
    Inventors: Thomas Augustinus Maria Beumer, Petrus Franciscus Hendrikus M. Verheijden, Hendrik Sibolt van Damme
  • Patent number: 8574913
    Abstract: Hemoglobin in a sample solution is quickly and reliably denatured; at the same time, quick and accurate measurement of hemoglobin and a hemoglobin derivative is realized. In a method for measuring hemoglobin and a hemoglobin derivative, and a reagent composition, a measurement kit, an analysis device, and an analysis system used in the method, a sample solution containing a blood component is treated with a nonionic surfactant, an oxidizing agent, and a metal salt to denature hemoglobin in the sample solution to measure the hemoglobin, and thereafter the amount of a hemoglobin derivative in the sample is measured by an immunological method using an antibody specifically binding to a denatured site of the denatured hemoglobin derivative.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: November 5, 2013
    Assignee: Panasonic Corporation
    Inventors: Hirotaka Tanaka, Masanori Tanaka
  • Publication number: 20130280725
    Abstract: The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preservation or storage of samples (e.g., biospecimen samples) by using one or more of a bridge, a membrane, and/or a desiccant.
    Type: Application
    Filed: April 22, 2013
    Publication date: October 24, 2013
    Applicants: California Institute of Technology, University of Chicago
    Inventors: Rustem F. Ismagilov, Qichao Pan, Stefano Begolo
  • Patent number: 8548772
    Abstract: An automatic method for identifying biological samples that are collected using the wrong blood preservative for subsequent analytical testing. The method also provides for identification and/or suppression of certain analytical test results that are substantially or partly adversely affected. The invention is particularly suited for use in point-of-care medical diagnostic testing.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: October 1, 2013
    Assignee: Abbott Point of Care Inc.
    Inventors: Eric Brouwer, Jody Ann Tirinato, Michael P. Zelin
  • Patent number: 8545772
    Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: October 1, 2013
    Assignee: Life Technologies Corporation
    Inventors: Tanya Kanigan, Steve Smith, John Linton, Robert Hess, Karl Yoder, Colin Brennan
  • Publication number: 20130244229
    Abstract: The present invention relates to a buffering composition, more closely a composition comprising porous matrix-enclosed buffering agent(s) giving a stabilisation of pH when applied in for example aqueous environment. The composition comprises buffering agent(s) enclosed in a first porous matrix with an impenetrability corresponding to a fractionation range for globular proteins and peptides of <10000 g/mol, preferably <5000 g/mol, more preferably <700 g/mol.
    Type: Application
    Filed: November 29, 2011
    Publication date: September 19, 2013
    Inventors: Jan Bergstrom, Bo-Lennart Johansson
  • Patent number: 8513025
    Abstract: This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry, e.g., tandem mass spectrometry, by derivatizing succinylacetone in a sample by contacting the sample with an extraction solution comprising a C1-3 linear or branched chain monoalcohol and a strong base selected from the group consisting of hydrazine, a modified hydrazine, and hydroxylamine.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: August 20, 2013
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Blas Cerda, Alex Cherkasskiy, Yijun Li
  • Patent number: 8465707
    Abstract: A sample handling method may include drawing an encapsulating liquid from an encapsulating-liquid input; discharging the drawn encapsulating liquid (a) onto a free surface of a carrier liquid in a carrier-liquid conduit comprising a stabilisation feature and (b) proximate to the stabilisation feature, the encapsulating liquid being immiscible with the carrier liquid, so that the discharged encapsulating liquid does not mix with the carrier liquid, floats on top of the carrier liquid, and is immobilised by the stabilisation feature; drawing a sample liquid from a sample-liquid input; and discharging the drawn sample liquid, the sample liquid being immiscible with the encapsulating liquid and with the carrier liquid, so that the sample liquid does not mix with the encapsulating liquid or with the carrier liquid.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: June 18, 2013
    Assignee: GenCell Biosystems Ltd.
    Inventors: Kieran Curran, Paul Fleming, Séamus Gillhooley, Micheál Keane, Inga Rosca, Patrick Tuohy
  • Patent number: 8426218
    Abstract: A filter assembly is provided for collecting samples in a fluid environment, the assembly utilizing a laminar convective flow to cause the flow of a preservative/fixative and a filtrate through a filter. A substantially concave dead space around the filter is flushed free of the preservative and the differential in density of the preservative and filtrate causes the more dense fluid to collect in the reservoir and preserve the collected specimen.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: April 23, 2013
    Assignee: McLane Research Laboratories, Inc.
    Inventors: Craig D. Taylor, Kenneth W. Doherty, Susumu Honjo
  • Patent number: 8389287
    Abstract: The present invention relates to methods for the collection of a sample from faecal material and, further, the detection of occult blood in or on the faecal material via the testing of the sample collected from the faecal material. The present invention also relates to collection methods comprising the use of a brush-like device having flexible or semi-flexible bristles wherein the brush-like device is contacted to the faecal material. The present invention also relates to detection of occult blood from the sample collected from the faecal material by means of a guaiac test or immunochromatographic test. The present invention additionally relates to the detection of one or more indicators of a pathological condition in or on the faecal material from which the sample is derived.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: March 5, 2013
    Assignee: Enterix PTY Limited
    Inventor: Howard Chandler
  • Patent number: 8383418
    Abstract: A method for operating a tissue processor is described. During the operation of a tissue processor a reagent is fed from a container into a retort of the tissue processor, which retort does not contain any tissue samples. Thereafter, the reagent is returned into the container. During feeding, returning and/or in between feeding and returning a measured value is detected by a sensor of the tissue processor. This value is representative of a concentration of the reagent. During this feeding, this returning and/or in between no tissue sample is placed in the retort.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: February 26, 2013
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Udo Herrmann, Hermann Ulbrich
  • Patent number: 8377695
    Abstract: A synthetic urine solution is described. The synthetic urine solution is a shelf stable, food grade composition formed of water having a pH between 3 and 10. A thickening agent is dissolved within the water to form a solution having a specific gravity between 1.025 g/cm3 and 1.225 g/cm3. To provide a realistic appearance and odor, a coloring agent and urea are dissolved within the solution. Finally, to provide a shelf stable product, a preservative is also dissolved within the solution.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: February 19, 2013
    Inventor: Brady Alfred Daniel
  • Patent number: 8360244
    Abstract: A new type of asymmetric flow field flow fractionator, A4F, is described permitting improved sample fractionation means by providing a range of available channel lengths within the same A4F unit. With such an apparatus, samples may be optimally separated by performing such fractionations as a function of channel length. The ability to vary channel length within the same A4F unit has heretofore been unavailable.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: January 29, 2013
    Assignee: Wyatt Technology Corporation
    Inventors: Philip J. Wyatt, Michelle H. Chen, David N. Villalpando
  • Patent number: 8357538
    Abstract: An automated assay processing method including transferring a first number of samples from respective sample containers to a first intermediary vessel, determining the testing adequacy of a second number of samples in a second intermediary vessel, preparing a third number of samples in a third intermediary vessel for downstream testing; and transferring a fourth number of samples from a fourth intermediary vessel to an output sample tray. These steps are all performed essentially simultaneously within the duration of a single clock cycle and are repeated during one or more subsequent clock cycles. The clock cycle may be relative to each intermediary vessel. The clock cycle also may be universal to the first, second, third and fourth intermediary vessels.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: January 22, 2013
    Assignee: Qiagen Gaithersburg, Inc.
    Inventors: Brian Austin Self, Fei Yin, Carl Theodore Edens
  • Patent number: 8329474
    Abstract: A container for use in processing a biopsy sample. Biopsy sample and materials are received within a sample processing area of the container. A semi-permeable barrier is positioned at a downstream portion of the sample processing area and prevents the prevent passage of the biopsy sample. A cap is positioned at the downstream side of the barrier, and holds fluids within the container.
    Type: Grant
    Filed: March 15, 2011
    Date of Patent: December 11, 2012
    Assignee: University of Massachusetts
    Inventor: Andrew H. Fischer
  • Patent number: 8318105
    Abstract: Systems and methods of biomarker analysis. In at least one embodiment of a system for determining the therapeutic potential of a therapeutic compound the present disclosure, the system comprises a detection platform, a computer database capable of receiving a plurality of binding characteristics, a processor operably coupled to the computer database and the detection platform. In at least one embodiment, the processor has and executes a software program operational to determine a binding characteristic of the detection agent and a stabilized diagnostic agent in each of the plurality of detection sites, compare the binding characteristic among each of the plurality of detection sites, wherein the comparison of binding characteristics is capable of determining the stabilizing agent with the greatest effect on the binding characteristic between the detection agent and the diagnostic agent, generate a binding record using the compared binding characteristics, and deliver the binding record to a recipient.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: November 27, 2012
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Patent number: 8318492
    Abstract: The present invention relates in one aspect to a method for determining the cell culture history of a cell unit labelled with more than one type of tag comprising the steps of: (a) measuring one or more parameters of each tag that is used to label the cell unit; (b) identifying each tag in the cell unit; and (c) correlating the identity of each tag to the identity of the cell unit and/or the specific cell culture conditions to which the cell unit has been exposed.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: November 27, 2012
    Assignee: Plasticell Limited
    Inventors: Yen Choo, Fraser Hornby, John Girdlestone
  • Patent number: 8293537
    Abstract: At least one embodiment of a stabilizing system includes a stabilizing agent present in an amount or concentration sufficient to completely or substantially prevent or reduce degradation or inactivation of a glycosylated hemoglobin (HbA1c) in a body fluid and a detection agent capable of detecting the HbA1c.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: October 23, 2012
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Publication number: 20120251999
    Abstract: The embodiments of the invention described herein relate to systems and methods for the vitrification of biological samples. Vitrification is achieved by generating nanodroplets of a solution comprising the biological sample with a means that can be automated and adapted to high-throughput applications.
    Type: Application
    Filed: February 1, 2012
    Publication date: October 4, 2012
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Utkan DEMIRCI, Emre KAYAALP, Sangjun MOON, Young Seok SONG, Xiaohui ZHANG
  • Patent number: 8263023
    Abstract: A microfluidic system and method for sorting cell clusters, and for the continuous and automated encapsulation of the clusters, once sorted, in capsules of sizes suitable for those of these sorted clusters is provided. The microfluidic system comprises a substrate in which a microchannel array comprising a cell sorting unit is etched and around which a protective cover is bonded, and the sorting unit comprises deflection means capable of separating, during the flow thereof, relatively noncohesive cell clusters, each of size ranging from 20 ?m to 500 ?m and of 20 to 10 000 cells approximately, such as islets of Langerhans, at least two sorting microchannels arranged in parallel at the outlet of said unit being respectively designed so as to transport as many categories of sorted clusters continuously to a unit for encapsulation of the latter, also formed in said array.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: September 11, 2012
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Sophie Le Vot, Jean Berthier, Florence Rivera
  • Patent number: 8262999
    Abstract: Tempering of sample (58) in test strip (37) is carried out by temperature regulating unit (40) and heating/cooling unit (92). The sample is fed to the test strip by a developer fluid (57) and a metering unit (55). The result of the detection reaction becomes visible by a change in color (36), which is detected optically and analyzed. The data of a control chart (52) with the measured values of first and second temperature sensors (41, 42) are used to set the control parameters for tempering. Code (86) on the test sample holder (35) is read in a sequence of steps. Parameters for phases of the measurement are determined from measured values of first and second temperature sensors, values of the control chart and the code of the test sample holder. These parameters are used by the temperature regulating unit during the measurement.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: September 11, 2012
    Assignee: Dräger Safety AG & Co. KGaA
    Inventors: Ingo Kaneblei, Thomas Wuske, Rainer Polzius, Björn Lange
  • Patent number: 8265904
    Abstract: An automatic method for identifying biological samples that are collected using the wrong blood preservative for subsequent analytical testing. The method also provides for identification and/or suppression of certain analytical test results that are substantially or partly adversely affected. The invention is particularly suited for use in point-of-care medical diagnostic testing.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: September 11, 2012
    Assignee: Abbott Point of Care Inc.
    Inventors: Eric Brouwer, Jody Ann Tirinato, Michael P. Zelin
  • Publication number: 20120220046
    Abstract: The invention discloses a method and apparatus for forming the doped cryo-biology specimen of electron microscope. The invention applies rapid cryogenic freezing to the biology specimen, and dopes certain concentration of protons and electrons into the cryo-biology specimen for conducting the observation using electron microscope. The invention reduces the radiation damage of cryogenic biology specimen and amorphous ice caused by the electron radiation, and observes the prototype of biomolecules and biomaterials clearly.
    Type: Application
    Filed: September 7, 2011
    Publication date: August 30, 2012
    Inventor: Chih-Yu Chao
  • Patent number: 8252139
    Abstract: A method of making a fluid sample collection card includes providing a support layer, forming an upper layer with a card stock, the upper layer including a sample window and a viewing window, supporting an absorbent layer with the support layer, and positioning the upper layer on the absorbent layer, wherein the upper layer is configured such that as a fluid is being absorbed by the first absorbent layer portion, presence of a portion of the fluid within the second absorbent layer portion indicates that a first volume of the fluid absorbed by the absorbent layer is a minimum necessary volume of the fluid sufficient to perform at least one test on at least one component in the fluid.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: August 28, 2012
    Assignee: Advance Dx, Inc.
    Inventor: Mark Lee Pankow
  • Publication number: 20120214248
    Abstract: A method for determining the concentration of chlorine dioxide in a chlorine dioxide solution having the following steps: (1) isolating two samples, Sample 1 and Sample 2, from the chlorine dioxide solution; (2) stripping the chlorine dioxide from Sample 1; (3) completely converting the chlorine dioxide in Sample 2 to other chlorine species; (4) transporting the chlorine dioxide samples either within the facility or outside the facility to a testing site; (5) separately determining the concentration of the chlorine containing species in each of Samples 1 and 2; and (6) calculating the concentration of chlorine dioxide in said chlorine dioxide solution based upon the information obtained in step (5).
    Type: Application
    Filed: December 21, 2011
    Publication date: August 23, 2012
    Inventors: Allison H. Sampson, Richard L. Sampson, George Dimotsis
  • Publication number: 20120164748
    Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
    Type: Application
    Filed: December 23, 2011
    Publication date: June 28, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Tanya S. Kanigan, Steve Smith, John Linton, Robert Hess, Karl Yoder, Colin Brennan
  • Publication number: 20120164676
    Abstract: The present invention provides methods for preventing clumping of cells in microfluidic devices by addition of diazolidinyl urea (DU). DU can be added to samples at the time of collection or can be added to samples post-collection. DU can also be pre-added to sample collection devices.
    Type: Application
    Filed: September 23, 2011
    Publication date: June 28, 2012
    Applicant: BIOCEPT, INC.
    Inventors: Pavel TSINBERG, Stephen D. MIKOLAJCZYK