Including Sample Preparation Patents (Class 436/174)
  • Patent number: 10940476
    Abstract: A device for high-throughput multi-parameter functional profiling of the same cells in multicellular settings and in isolation is provided. In certain aspects, an integrated microfluidic device for multi-parameter metabolic and other phenotypic profiling of live biological cells is useable with: 1) multicellular clusters or small biopsy tissue samples, 2) cultures of the constituent cells obtained after cluster/tissue dissociation, and 3) the same constituent single cells in isolation. The approach enables study of the effects of multicellular complexity, such as in response to treatment, pathogens, stress, or other factors concerning disease origination and progression. Measurements may be performed on single cells or multicellular populations or tissues in the same assay at the same time.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: March 9, 2021
    Inventors: Laimonas Kelbauskas, Honor Glenn, Jeff Houkal, Clifford Anderson, Yanqing Tian, Fengyu Su, Deirdre Meldrum
  • Patent number: 10816451
    Abstract: A system for building a gas processing apparatus includes a compressed gas source, a pressure modulator in communication with the gas source, and a chamber configured to receive a gas permeable material. The chamber is further configured with a first chamber area on one side of the material and with a second chamber area on a second side of the material. A sensor is configured to measure over time a pressure differential between the first and second chamber areas. A memory stores performance characteristic data for a plurality of gas processing apparatus. A processor converts the pressure differential to a material characteristic of the gas permeable material, and compares the material characteristic to at least one selected performance characteristic of the gas processing apparatus.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: October 27, 2020
    Assignee: Honeywell International Inc.
    Inventor: David Loeffelholz
  • Patent number: 10791975
    Abstract: A biological fluid sampling transfer device adapted to receive a multi-component blood sample is disclosed. After collecting the blood sample, the biological fluid sampling transfer device is able to separate a plasma portion from a cellular portion. After separation, the biological fluid sampling transfer device is able to transfer the plasma portion of the blood sample to a point-of-care testing device. The biological fluid sampling transfer device also provides a closed sampling and transfer system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer. The biological fluid sampling transfer device is engageable with a blood testing device for closed transfer of a portion of the plasma portion from the biological fluid sampling transfer device to the blood testing device. The blood testing device is adapted to receive the plasma portion to analyze the blood sample and obtain test results.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: October 6, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: Bradley M. Wilkinson, Daniel J. Marchiarullo, Gary D. Fletcher
  • Patent number: 10777331
    Abstract: Processes for producing germanium-68 from a gallium target body are disclosed. In some embodiments, germanium-68 and gallium are precipitated to remove metal impurities. Germanium-68 and gallium are re-dissolved and loaded onto an ion exchange column to separate germanium-68 from gallium.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: September 15, 2020
    Assignee: Curium US LLC
    Inventors: David Pipes, William Uhland, Melissa Perrigo, Mark Owens
  • Patent number: 10760999
    Abstract: Methods and apparatus are provided for transfer of a tissue section from a first location to a second location. Thermoplastic material is applied to at least one pin of a tissue section transferring apparatus. The thermoplastic material contacts a tissue section while at least partially melted, and when it cools, substantially solid thermoplastic material holds the tissue section to the at least one pin. A tissue section transferring apparatus comprises a heater block, a heat source, and at least one pin attached to and extending from the heater block.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: September 1, 2020
    Inventor: Victor Lim
  • Patent number: 10690582
    Abstract: An apparatus for sensing biomolecules includes: a storage in which a solution containing a target material is received; a sensor configured to sense the target material; and a flow controller connected between the storage and the sensor to supply the solution to the sensor, wherein the flow controller controls a solution flow to supply the solution containing the target material and the solution containing no target material in an alternating manner. According to the apparatus for sensing biomolecules, the sensing device always achieves a sensing offset, and consequently, long-term continuous measurement is enabled, leading to the maximized usage efficiency of the sensor, and the value of quantitative measurement can be obtained with high precision.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: June 23, 2020
    Inventors: Jaebin Choi, Chulki Kim, Sang Kyung Kim, Seok Lee, Chaehyun Lim, Jae Hun Kim, Taikjin Lee, Minah Seo
  • Patent number: 10648969
    Abstract: A method and device for quality controlling a blood-based product. In order to control the quality of a blood-based product which comprises an erythrocyte concentrate, a thrombocyte concentrate, a granulocyte concentrate, a leukocyte concentrate, whole blood and/or blood plasma, a Raman spectrum is recorded. By means of evaluating the Raman spectrum, it is determined whether the blood-based product can be used for a transfusion.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: May 12, 2020
    Assignee: CellTool GmbH
    Inventors: Raimund Schütze, Karin Schütze
  • Patent number: 10622201
    Abstract: A method for preparing thin layers from liquid samples is disclosed. Such thin layers can be useful when analyzing samples with probes whose penetration length in these samples is short The method consists of squeezing a certain amount of a liquid sample between two approximately flat and parallel surfaces separated by a small distance then cooling down the liquid sample until it freezes in a way that the frozen sample adheres only to one of these two flat surfaces. Removing the non-adhered flat surface leaves the frozen sample layer with the thickness approximately equal to the initial distance between the two parallel surfaces.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: April 14, 2020
    Inventor: Kresimir Franjic
  • Patent number: 10585518
    Abstract: Display module support techniques are described. In one or more implementations, an apparatus includes an external enclosure forming a cavity and a touch display module. The touch display module includes a touch panel assembly having one or more touch sensors and a display module to output a display through at least a portion of the touch panel assembly. The apparatus also includes a support that secures the touch display module to the external enclosure. The support is secured to the external enclosure using a reworkable connection.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: March 10, 2020
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: David J. Huston, James Michael Bonicatto, Kenneth Charles Boman, Andrew William Hill, John Stephen Campbell
  • Patent number: 10584329
    Abstract: The invention generally relates to methods for universal target capture.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: March 10, 2020
    Assignee: DNAE Group Holdings Limited
    Inventor: Colin Dykes
  • Patent number: 10570439
    Abstract: The present disclosure relates to a concentrator for concentrating, purifying or otherwise isolating one or more target analytes in a fluid matrix, and related methods, using self-wicking materials, such as monoliths. The present disclosure can be used as a point-of need sample preparation device. The self-contained device can be used for the extraction and concentration of specific target molecules, such as nucleic acids.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: February 25, 2020
    Assignees: Monolythix, Inc., Alfred E. Mann Foundation for Scientific Research
    Inventors: Keith A. Oberg, Anthony Spence, Ivan Rueda, Mark D. Dobbs, Milton Lee
  • Patent number: 10557177
    Abstract: A method for characterizing toxicity of toxic pollutants and a method for characterizing comprehensive toxicity of water bodies. The methods include constructing a reporter gene cell line expressing CHOP gene associated with endoplasmic reticulum stress.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: February 11, 2020
    Inventors: Bing Wu, Yue Yu, Huimei Chen, Su Liu, Xuxiang Zhang, Hongqiang Ren
  • Patent number: 10527528
    Abstract: The present invention relates to systems and methods for tissue processing and analysis. Tissue chambers are configured to allow single-container chemical processing, imaging, and wax embedding of tissue samples in a single container without manipulation between steps. Tissue chambers with features to support the tissue sample and allow fluid flow between the tissue sample and the tissue chamber surface are disclosed. The features may be index matched to sample structures of interest or dissolvable in clearing solution to allow for in-chamber imaging with minimal distortion. Specialized tissue processing and wax removal apparatuses are also disclosed including for use with tissue chambers having frangible portions to permit ease of wax removal.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: January 7, 2020
    Inventors: Michael Levene, Richard Torres
  • Patent number: 10450600
    Abstract: The present invention relates to a method of designing DNA probe chip for room-temperature hybridization in order to solve the solvent evaporation problem occurring when carrying out said hybridization at a high temperature of 40° C.˜50° C. or higher, wherein the method is designed to allow genotyping through hybridizing at a room temperature of 20° C.˜30° C. The method of designing DNA probe chip comprises designing DNA probe to start at ?10˜+5 position that is between ?10 position which is overlapped 10 sequences with primer and +5 position which is 5 sequences far from the 3?-terminal of primer, based on 0 position which is 3?-terminal of primer.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: October 22, 2019
    Inventors: Tae Sun Kim, Keum Soo Song, Woon Yong Eoum, Chan Young Jung
  • Patent number: 10416225
    Abstract: A detection method for an LED chip comprising the following steps: providing a container with a solvent therein, and putting the LED chips in the container to mix the LED chips with the solvent; providing a base with a circuit therein, the base forms a plurality of receiving holes, a bottom of each receiving holes have an N electrode and a P electrode coupled with the circuit; transferring the solvent and the LED chip mixed in the solvent on the base; detecting the LED chip received in the receiving holes; providing a carrier film and classifying the LED chips on the carrier film.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: September 17, 2019
    Inventors: Po-Min Tu, Tzu-Chien Hung, Chia-Hui Shen, Chien-Shiang Huang, Chien-Chung Peng, Ya-Wen Lin, Ching-Hsueh Chiu
  • Patent number: 10393725
    Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: August 27, 2019
    Assignee: CELLOMICS, INC.
    Inventors: Richik Niloy Ghosh, Dirk John VandenBerg, III, Keith Rao Heffley, Monica Jo Tomaszewski, Jeffrey Robert Haskins
  • Patent number: 10379016
    Abstract: The apparatus for inoculating agar plates includes a spray chamber having an upper opening for receiving an atomized microbial suspension and a lower opening for receiving an agar plate. The apparatus also includes an atomizer including a reservoir and a fluid tube for delivering the microbial suspension to the atomizer nozzle. A containment feature extends around an inner surface of the spray chamber to catch any drop that may form on its inner wall and advance down towards the lower opening. The spray chamber allows multiple agar plates to be quickly inoculated without cross-contamination of agar habitats, without contaminating the outside of the plates, and without contaminating the work area.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: August 13, 2019
    Assignee: King Saud University
    Inventors: Mohd Aftab Alam, Fahad Ibrahim Al-Jenoobi, Mohamed Hamed M. Al-Agamy
  • Patent number: 10361337
    Abstract: Micro light-emitting diode (LED) displays and assembly apparatuses are described. In an example, method of manufacturing a micro-light emitting diode (LED) display panel includes positioning a display backplane substrate in a tank or container, the display backplane substrate having microgrooves therein. The method also includes adding a fluid to the tank or container, the fluid including a suspension of light-emitting diode (LED) pixel elements therein. The method also includes moving the fluid over the display backplane substrate. The method also includes assembling LED pixel elements from the fluid into corresponding ones of the microgrooves.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: July 23, 2019
    Assignee: Intel Corporation
    Inventors: Khaled Ahmed, Anup Pancholi, Ali Khakifirooz
  • Patent number: 10345240
    Abstract: The invention combines recent advances in barcode technology with portable wireless communication devices to engineer a simple and low-cost chip-based multiplex wireless detection system. The system can analyze multiple targets of interest simultaneously in minutes and is applicable to detection of pathogens or contaminants in a wide range of fields including medicine, agriculture and the environment.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: July 9, 2019
    Inventors: Warren Che Wor Chan, Kevin Ming
  • Patent number: 10266204
    Abstract: A lane-maintaining control device detects a lane width (H1) of a traveling lane (21) through a camera (4) and performs lane-maintaining control without a deviation from the lane width (H1). When detecting, through the camera (4), that the traveling lane (21) gradually increases (H2>H1 where the increasing lane width is (H2)), the lane-maintaining control device continues the lane-maintaining control on a condition that a turn signal is not operated.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: April 23, 2019
    Inventors: Kazunori Isomoto, Shusaku Ombe, Hiroshi Ohmura, Kouichi Kojima, Tsuyoshi Arinaga
  • Patent number: 10267794
    Abstract: Disclosed herein is an aptamer sensor including a substrate having metal nanoparticles formed thereon, an aptamer attached to surfaces of the metal nanoparticles to form a structure by selectively reacting with a target material to be detected, and an intercalating agent inserted between the aptamer and the target material in reaction of the aptamer with the target material to increase shift of an absorption spectrum due to local surface plasmon resonance sensor through aggregation toward the metal nanoparticles.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: April 23, 2019
    Inventors: Min-Gon Kim, Jin-Ho Park, Ju Young Byun
  • Patent number: 10183293
    Abstract: A reagent reservoir for fluids, including a storage chamber connected to a duct for conducting fluid out of, into and/or through the storage chamber. The duct includes a duct section delimited by a substrate and a film joined to the substrate. The duct is sealed and is openable at a predetermined breaking point by deflecting the film. The film also delimits the storage chamber and covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and an edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall, which is formed in the edge portion and runs parallel to the film, determine the surface area of the joining region.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: January 22, 2019
    Inventor: Lutz Weber
  • Patent number: 10166330
    Abstract: A pharmaceutical drug delivery system having a base (1) comprising at least two inlets (2), an outlet (20) and a passive mixing chamber (7) having micro pin fins (8) with heights in the range of 10 to 100???? characterized in that the base (1) is selectively coated with nanostructures which are made of a material different than the material of said base, such that the base (1) comprises a plurality of regions R1 to RN each having a different nanostructure coating intensity, and such that a surface tension gradient is established among regions R1 to RN for promoting fluid flow towards the outlet (20). The present invention further proposes a method for obtaining a pharmaceutical drug delivery system.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: January 1, 2019
    Inventors: Ali Kosar, Osman Yavuz Perk
  • Patent number: 10018627
    Abstract: A technique for efficiently sealing many substances, such as beads, nucleic acid, protein, virus, cells, and lipid membrane complex, into an array is provided. The present invention provides a method for sealing a substance, including: (i) a step of introducing a first solvent containing a substance on a substrate on which a plurality of receptacles capable of storing the substance are formed separated from each other by a side wall; and (ii) a step of introducing a second solvent having a greater specific gravity than that of the first solvent onto the first solvent, the step (ii) being carried out after the step (i).
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: July 10, 2018
    Inventors: Hiroyuki Noji, Lisa Yamauchi
  • Patent number: 9930453
    Abstract: The present invention provides a silicon microphone with a high-aspect-ratio corrugated diaphragm and a microphone package including the same. The microphone comprises the corrugated diaphragm on which at least one ring-shaped corrugation is formed in the vicinity of the edge of the diaphragm which is fixed to the substrate, the corrugated diaphragm is flexible, wherein the ratio of the depth of the corrugation to the thickness of the diaphragm is larger than 5:1, preferably 20:1, and the walls of the corrugation are inclined to the surface of the diaphragm at an angle in the range of 80° to 100°. The microphone with the high-aspect-ratio corrugated diaphragm can achieve a consistent and optimal sensitivity and greatly reduce impact applied thereto in a drop test so that the performances, the reproducibility, the reliability and the yield can be improved. The microphone package of the present invention further provides a simplified processing, an improved sensitivity and an improved SNR.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: March 27, 2018
    Assignee: GOERTEK INC.
    Inventors: Quanbo Zou, Zhe Wang
  • Patent number: 9902990
    Abstract: Microfluidic devices are provided for trapping, isolating, and processing single cells. The microfluidic devices include a cell capture chamber having a cell funnel positioned within the cell capture chamber to direct a cell passing through the cell capture chamber towards one or more a cell traps positioned downstream of the funnel to receive a cell flowing. The devices may further include auxiliary chambers integrated with the cell capture chamber for subsequent processing and assaying of the contents of a captured cell. Methods for cell capture and preparation are also provided that include flowing cells through a chamber, funneling the cells towards a cell trap, capturing a predefined number of the cells within the trap, interrupting the flow of cells, flowing a wash solution through the chamber to remove contaminants from the chamber, and sealing the predefined number of cells in the chamber.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: February 27, 2018
    Assignee: The University of British Columbia
    Inventors: Carl Lars Genghis Hansen, Michael VanInsberghe, Adam White, Oleh Petriv, Tim Leaver, Anupam Singhal, William Bowden, Veronique Lecault, Dan Da Costa, Leo Wu, Georgia Russell, Darek Sikorski
  • Patent number: 9821308
    Abstract: Disclosed is a device for the directed capillary transport of liquids, comprising at least two capillaries (8, 9, 33, 54, 55), the at least two capillaries (8, 9, 33, 54, 55) being designed such that the liquid can be transported in at least some regions in a passive, directed and capillary manner, characterised in that at least two of the capillaries (8, 9, 33, 54, 55) are interconnected in the direction of transport of the liquid via at least one capillary passage conduit (20, 23, 28, 29, 34, 40, 41, 59, 63). The invention is intended for use in the separation of components from a fluidic substance and/or in oil/water separation. A production method is characterised in that at least one part of the capillary structure is generated by means of laser irradiation, by means of a moulding tool, in particular a sintering mould, by means of a milling process, in particular by means of a micro-milling process, or by means of EDM.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: November 21, 2017
    Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.v.
    Inventors: Philipp Comanns, Werner Baumgartner, Frank Bernhardt, Kai Winands, Kristian Arntz
  • Patent number: 9791464
    Abstract: The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: October 17, 2017
    Inventors: Michael P. Caulfield, Richard E Reitz, Shuguang Li, Gloria Kwangja Lee, Ronald Krauss, Patricia J. Blanche, W. Henry Benner, Earl Cornell
  • Patent number: 9757725
    Abstract: A system that includes a cartridge housing and a hollow transfer module, according to an embodiment is described herein. The cartridge housing further includes at least one sample inlet, a plurality of storage chambers, a plurality of reaction chambers, and a fluidic network. The fluidic network is designed to connect the at least one sample inlet, a portion of the plurality of storage chambers and the portion of the plurality of reaction chambers to a first plurality of ports located on an inner surface of the cartridge housing. The hollow transfer module includes a second plurality of ports along an outer surface of the transfer module that lead to a central chamber within the transfer module. The transfer module is designed to move laterally within the cartridge housing. The lateral movement of the transfer module aligns at least a portion of the first plurality of ports with at least a portion of the second plurality of ports.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: September 12, 2017
    Assignee: Stat-Diagnostica & Innovation, S.L.
    Inventors: Jordi Carrera Fabra, Anna Comengés Casas, Rafael Bru Gibert
  • Patent number: 9733166
    Abstract: A tissue embedder comprising a transport mechanism for an input member, the input member adapted to hold a plurality of tissue supports, with each tissue support associated with a mould, a wax bath and a cooling station wherein the transport mechanism moves the input member from a wax bath to a cooling station.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: August 15, 2017
    Inventors: Eduardo Vom, Chester John Henderson, Craig Matthew Lewis
  • Patent number: 9638621
    Abstract: A method for identifying, analyzing, and quantifying the cellular components of whole blood by means of an automated hematology analyzer and the detection of the light scattered, absorbed, and fluorescently emitted by each cell. More particularly, the aforementioned method involves identifying, analyzing, and quantifying the cellular components of whole blood by means of a light source having a wavelength ranging from about 400 nm to about 450 nm and multiple in-flow optical measurements and staining without the need for lysing red blood cells.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: May 2, 2017
    Assignee: Abbott Laboratories
    Inventors: Martin Krockenberger, Jiong Wu, Bodo Roemer, Giacomo Vacca
  • Patent number: 9551700
    Abstract: The present invention discloses a novel device and methods thereof with utility application in the high-throughput detection, screening and disease management of cervical disease. The “multiwell” device of the present invention consists of a solid support featuring multiple well-separated areas, each accommodating a patient sample, leading to simultaneous evaluation of patient samples. The methods of the present invention comprise conventional cytological staining, cervical Pap staining, and immunochemical staining using antibodies or combination of antibodies which are capable of binding to biomarkers that are overexpressed in cancer including in cervical carcinoma and dysplasia, as compared to normal controls. The device and methods of the present invention can be practiced in either manual or automated mode, and applied to any biological fluid or cell suspension from any biological specimen in view of a variety of cell biology assays, and in view of detection and screening of cervical and other diseases.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: January 24, 2017
    Assignee: MILAGEN, INC.
    Inventor: Moncef Jendoubi
  • Patent number: 9476811
    Abstract: Devices and methods are provided for performing droplet-based solid phase processing steps on a digital microfluidic device. A solid phase material, which may be a porous solid phase material such as a porous polymer monolith is formed or located on a digital microfluidic element. The solid phase may be formed by an in-situ method in which the digital microfluidic array is actuated to transport a droplet of solid phase pre-cursor solution to a selected element on the array, and subsequently processed to form a solid phase on the array element. The integration of a solid phase material with a digital microfluidic array enables a wide range of applications including solid phase extraction and sample concentration.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: October 25, 2016
    Assignee: The Governing Council of the University of Toronto
    Inventors: Jared M. Mudrik, Hao Yang, Aaron R. Wheeler
  • Patent number: 9448142
    Abstract: A milk sampling system for use with an automatic milking machine includes a metering pump (2) having an inlet (9) connected to a induction system (3) and an outlet (10) connected to a discharge system (5). The induction system includes a manifold block (4) with passages forming supply paths (12, 13, 15) for connecting the pump inlet to a milk source, a washing fluid source, and a source of pressurized air, and solenoid valves (21, 22, 25) to selectively open and close the supply paths. The discharge systems includes a manifold block (6) with passages forming a plurality discharge paths (27, 29, 31, 33) for successively delivering discrete milk samples for analysis, and solenoid valves (35, 36, 37, 38) to selectively open and close the discharge paths.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: September 20, 2016
    Inventor: Mats Gudmundsson
  • Patent number: 9434940
    Abstract: The invention generally relates to methods for universal target capture.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: September 6, 2016
    Assignee: DNA Electronics, Inc.
    Inventor: Colin Dykes
  • Patent number: 9381513
    Abstract: A detection chip is provided. The detection chip includes a substrate, an active reagent, a hydrophilic droplet and a lipophilic substance. The substrate includes a first containing slot, wherein the first containing slot includes a first space and a second space adjacent to each other. The active reagent is disposed in the first space of the first containing slot. The hydrophilic droplet is disposed in the second space of the first containing slot. The lipophilic substance is disposed in the first containing slot, wherein the lipophilic substance is immiscible to the active reagent and the hydrophilic droplet, and separates the active reagent from the hydrophilic droplet.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: July 5, 2016
    Assignee: Industrial Technology Research Institute
    Inventors: Liang-Ju Chien, Yu-Ying Lin, Chi-Han Chiou
  • Patent number: 9372080
    Abstract: The invention relates to an adjustment system (3) for a transfer system (1) in an in-vitro diagnostics system. The adjustment system comprises a contact element (4), which is arranged on a movable element (2) of the transfer system (1). The contact element (4) is arranged on the movable element (2) by means of a joint element (5), wherein the joint element (5) has a self-resetting design and wherein a distance measuring sensor (7, 8) is associated with a distance between the contact element (4) and the movable element (2). The adjustment system enables a quick automated adjustment.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: June 21, 2016
    Inventors: Achim Herz, Alexander Wiedekind-Klein
  • Patent number: 9322052
    Abstract: A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel comprises a rigid frame defining the side walls of a reaction chamber. The frame includes at least one channel connecting the flow path to the chamber. The vessel also includes flexible films or sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber. In addition, at least two of the side walls are optically transmissive and angularly offset from each to permit real-time optical detection of analyte in the reaction chamber.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: April 26, 2016
    Assignee: Cepheid
    Inventors: Kurt E. Petersen, William McMillan, Farzad Pourahmadi, Ronald Chang, Douglas B. Dority
  • Patent number: 9299476
    Abstract: Disclosed herein is a polymeric material comprising a conductive polymer substantially homogeneously distributed within a hydrogel. Also disclosed are methods for making the polymeric material and uses for the polymeric material.
    Type: Grant
    Filed: June 9, 2011
    Date of Patent: March 29, 2016
    Inventors: Rylie Adelle Green, Laura Anne Poole-Warren, Sungchul Baek, Penny Jo Martens
  • Patent number: 9289764
    Abstract: Methods and apparatus for mixing at least one sample solution with at least one reagent in at least one chamber of a microfluidic cartridge such that at least one reagent (R) is supplied to the sample solution (P) and brought into contact therewith by way of at least one movable component. In this way the loss of sample liquid or analyte can be reduced.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: March 22, 2016
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Berthold Lange, Christian Schoen, Tobias Eichmann
  • Patent number: 9267876
    Abstract: The present invention relates to a cell for optical analysis, wherein a flow space of a low depth is formed by attachment, using a simple double-coated tape without out special processing, of a micro flow channel through which a liquid sample passes, thereby enabling: a very easy manufacturing method; a reduction of manufacturing costs, thereby allowing the cell to be more widely used; a maintenance of a short path length of light with respect to the flow space in which the liquid sample flows, thereby enabling accurate optical analysis without diluting a sample with high absorbance; an expansion of a flow space region along the plane vertical to the light-passing direction, thereby enabling smoother optical analysis and improving the accuracy of optical analysis.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: February 23, 2016
    Assignee: I-SENS, INC.
    Inventors: Young Jae Kang, Tae Young Kang
  • Patent number: 9089850
    Abstract: Systems and methods for separating particles of pharmaceutically active materials, based on differences in density.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: July 28, 2015
    Assignee: Syracuse University
    Inventors: Bruce S. Hudson, Jack Melton
  • Patent number: 9074250
    Abstract: Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided, as are methods for using such cartridges. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: July 7, 2015
    Assignee: Luminex Corporation
    Inventors: Dylan Hilmer Bird, Jesus Ching, Bruce A. Johnson, Keith E. Moravick, Bruce Richardson
  • Patent number: 9052256
    Abstract: A method for treating a tissue sample including placing at least one tissue sample on an cassette which has: a retaining member, a base and at least one biasing element; placing the at least one tissue sample in the tissue cassette; attaching the base and the retaining member to retain the tissue sample; processing the tissue sample in the tissue cassette with one or more solvents; and embedding the tissue sample in a paraffin to form an portion of paraffin in which the tissue sample is embedded in the tissue cassette, wherein the embedding comprises adding molten paraffin to the interior area of the tissue cassette and allowing the paraffin to become solid.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: June 9, 2015
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Stella Knorr, Andrew Guy, Ralf Eckert, Fiona Tarbet, Fernando Dias, Chris Ryan, Neil Sanut
  • Patent number: 9044748
    Abstract: A cartridge capable of storing a chemical solution includes a first container, a second container installed within the first container and configured to store the chemical solution, and an exhaust path configured to exhaust a gas generated by the chemical solution stored in the second container, wherein the exhaust path is disposed between the first container and the second container.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: June 2, 2015
    Inventor: Takashi Koyama
  • Patent number: 9040255
    Abstract: The present invention provides methods for preventing clumping of cells in microfluidic devices by addition of diazolidinyl urea (DU). DU can be added to samples at the time of collection or can be added to samples post-collection. DU can also be pre-added to sample collection devices.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: May 26, 2015
    Assignee: BIOCEPT, INC.
    Inventors: Pavel Tsinberg, Stephen D. Mikolajczyk
  • Patent number: 9034651
    Abstract: This invention relates to methods and apparatus for determination of ion concentrations, particularly in downhole water from hydrocarbon wells, aquifers etc. It is useful in a wide range of applications, including predicting the formation of scale and fingerprinting waters from different sources. More particularly, the invention relates to the use of ligands whose electronic configuration is altered by the binding of the scaling ions within a water sample. These alterations are detected electrochemically by applying varying potential to electrodes and measuring current flow as potential is varied, from which is derived the concentration of scaling ions in the fluid.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: May 19, 2015
    Assignee: Schlumberger Technology Corporation
    Inventors: Li Jiang, Timothy Gareth John Jones, Andrew Meredith, Markus Pagels, Amilra Prasanna De Silva
  • Publication number: 20150132746
    Abstract: Provided herein is technology relating to the collection of biological samples and particularly, but not exclusively, to compositions, methods, and uses related to using a biopolymer substrate to collect biological samples for analysis.
    Type: Application
    Filed: May 29, 2013
    Publication date: May 14, 2015
    Inventors: Astrid Gjelstad, Lars Erik Eng Eibak, Anne Bee Hegge, Knut Einar Rasmussen, Stig Pedersen-Bjergaard
  • Patent number: 9029162
    Abstract: Disclosed are methods and systems for the analysis of testosterone in a sample using supported liquid extraction and liquid chromatography-mass spectrometry.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: May 12, 2015
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Russell Philip Grant, Matthew Crawford, Donald Walt Chandler, William Curtin
  • Patent number: 9029158
    Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: May 12, 2015
    Assignee: California Institute of Technology
    Inventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey Kasdan