Including Use Of A Solid Sorbent, Semipermeable Membrane, Or Liquid Extraction Patents (Class 436/178)
  • Patent number: 11609505
    Abstract: Embodiments of the present disclosure generally relate to apparatus and methods for verification and re-use of process fluids. The apparatus generally includes a tool for performing lithography, and a recirculation path coupled to the tool. The recirculation path generally includes a collection unit coupled at first end to a first end of the tool, and a probe coupled at a first end to a second end of the collection unit, the probe for determining one or more characteristics of a fluid flowing from the tool. The recirculation path of the apparatus further generally includes a purification unit coupled at a first end to a third end of the collection unit, the purification unit further coupled at a second end to a second end of the probe, the purification unit for changing a characteristic of the fluid.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: March 21, 2023
    Assignee: Applied Materials, Inc.
    Inventors: Mangesh Ashok Bangar, Gautam Pisharody, Lancelot Huang, Alan L. Tso, Douglas A. Buchberger, Jr., Huixiong Dai, Dmitry Lubomirsky, Srinivas D. Nemani, Christopher Siu Wing Ngai
  • Patent number: 11609204
    Abstract: Various embodiments of the present disclosure are directed to carbon dioxide and/or hydrogen sulphide sampling and detection system and method for determination of the content of gaseous CO2 and/or H2S in a liquid, among other chemical compounds. In one embodiment, the detection system includes a membrane block having a liquid sample inlet port and a sample outlet port between which a sample flow path extends. The membrane block includes a first membrane unit and a second membrane unit. The first membrane unit includes a sample flow on the first side of a first permeable membrane element, and a carrier gas flow on the second side of the first permeable membrane element. The second membrane unit having a sample flow on the first side of a second permeable membrane element and a carrier gas flow on the second side of the second permeable membrane element.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: March 21, 2023
    Assignee: Blue Unit A/S
    Inventor: David Alexander Owen
  • Patent number: 11548002
    Abstract: Systems and techniques are described for capturing target extracellular vesicles from a fluid sample. In some implementations, a microfluidic device includes a microfluidic channel where an internal surface of at least one wall of the microfluidic channel includes a plurality of grooves or ridges, or both grooves and ridges, arranged and configured to generate chaotic mixing within a fluid sample flowing through the microfluidic channel. The microfluidic device also includes a plurality of elongate flexible linker molecules, each having a molecular weight between about 1.8-4.8 kDa, where each elongate flexible linker molecule is bound at a first end to an internal surface of at least one wall of the microfluidic channel and is bound at a second end to one or more binding moieties that specifically bind to a target extracellular vesicle.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: January 10, 2023
    Assignee: The General Hospital Corporation
    Inventors: Eduardo Reategui, Shannon Stott, Mehmet Toner
  • Patent number: 11541329
    Abstract: Method and system for the extraction of oils from a biomass with a liquid carbon dioxide using cosolvent. The system and method can be used to extract cannabinoids from cannabis biomass by cryogenically freezing the biomass and exposing the cannabis biomass to sub-cooled liquid carbon dioxide and capturing a first high-terpene extract fraction, and then exposing the cannabis biomass with a mixture of superfluid carbon dioxide and a cosolvent to capture a high cannabinoid second fraction.
    Type: Grant
    Filed: January 28, 2022
    Date of Patent: January 3, 2023
    Assignee: Vitalis Extraction Technology Inc.
    Inventors: James Anthony Seabrook, Kiran Dayaram, Spencer Hugh Martin, Raymond Lyle Brown, Sean Cameron Demers
  • Patent number: 11530964
    Abstract: A sensor system comprising a housing having an inlet aperture through which fluid enters the housing and a conditioning material in the housing, the conditioning material being adapted to control levels of a substance within the housing. The sensor system comprises a sensor for analysing the fluid in the housing. The sensor system comprises circulation means which is configured to alternate circulation of fluid within the housing between a sensing fluid path in which the fluid is analysed by the sensor and a second fluid path in which the fluid flow is conditioned. A method for analysing fluid in a housing using a sensor is also provided.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: December 20, 2022
    Inventors: Andrew H. Koehl, Max Allsworth
  • Patent number: 11499896
    Abstract: A sample probe for sorptive sampling comprises an elongate body having a longitudinal axis defined along its length and a radial axis extending transverse to the longitudinal axis. A sorbent element formed of a sorbent material is secured to the body. The elongate body has an outer surface and a recess located along the length of the body that extends radially into the outer surface. The sorbent element is at least partially received within the recess of the body which mechanically locks the sorbent element to the body to prevent relative longitudinal movement of the sorbent element relative to the body.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: November 15, 2022
    Assignee: Markes International Limited
    Inventor: Martyn Rhys Cole
  • Patent number: 11491487
    Abstract: Devices and methods for measuring analytes and target particles in a sample are disclosed. In some embodiments, the disclosure provides a cartridge device. In other embodiments, the disclosure provides a method of using a cartridge device as disclosed herein for analyzing analytes and target particles in a sample. In further embodiments, the disclosure provides an analyzer including a cartridge device and a control unit device. The control unit device is configured to receive, operate, and/or actuate the cartridge device. In some embodiments, the disclosure provides a method of using an analyzer as disclosed herein for analyzing analytes and target particles in a sample.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: November 8, 2022
    Assignee: CytoChip Inc.
    Inventors: Wendian Shi, Yuzhe Ding, Yuan Gao
  • Patent number: 11458471
    Abstract: The disclosure relates to an arrangement (100?) in a capillary driven fluidic system for preventing wicking of a fluid along an edge (105) between a first substrate (110?) and a second substrate (120?), said arrangement comprising: a first substrate (110?) including a microfluidic channel (114) arranged to house the fluid, a second substrate (120?) arranged to cover a portion of the first substrate (110?), wherein the microfluidic channel (134) of the first substrate (110?) meets the second structure (120?) at a position (124) along an edge (105) defined between the first (110?) and second (120?) substrates, wherein the first and the second substrate collectively define a trench (130) for stopping wicking of the fluid along the edge (105), said trench (130) being arranged in at least one of the first substrate (110?) and the second substrate (120?), and located at a distance from said position (124) along the edge (105) and intersecting the edge (105).
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: October 4, 2022
    Assignee: miDiagnostics NV
    Inventor: Benjamin Jones
  • Patent number: 11280767
    Abstract: A pretreatment method for analyzing dioxin compounds and an analytical method using the same, in which a column packed with polymer beads that are capable of selectively adsorbing dioxin compounds is used in a purification step during pretreatment, thereby remarkably reducing a time required for pretreatment and improving a recovery rate of an internal standard for purification, are provided.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: March 22, 2022
    Inventors: Yeu Young Youn, Byoung Hyoun Kim, Young Hee Lim, Hye Sung Cho, Su Youn Han, Mi Ra Hong, Yeon Hwa Lee
  • Patent number: 11200823
    Abstract: The present disclosure provides a microarray adsorption substrate, a driving circuit, and a display device. A temporary base is adsorbed on a temporary substrate by charging an electrostatic adsorption microarray structure on the temporary base. After the processing is completed, the temporary base is stripped off from the temporary substrate by discharging the electrostatic adsorption microarray structure, thereby greatly reducing the damage to the temporary base during stripping.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: December 14, 2021
    Inventor: Yanying Du
  • Patent number: 11198139
    Abstract: Methods and apparatus for detection and/or identification of analytes including bacteria using dielectrophoresis and electroosmotic traps. Switching between different frequencies of an applied electric field results in movement of the analyte between dielectrophoresis and electroosmotic trapping states. The use of edge-based sensing techniques enables the use of electrodes with a larger form factor than nanowire sensors. Signal modulation based on analyte contact with the electrode edge is also described.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: December 14, 2021
    Assignee: Fluid-Screen, Inc.
    Inventor: Monika Weber
  • Patent number: 11193930
    Abstract: Devices and methods for performing pre-analysis sample processing of biological and chemical samples using robotic liquid handlers are disclosed. Methods for solid phase extraction, protein precipitation and filtration of biological and chemical samples using automation and the devices in a rapid and convenient way are described.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: December 7, 2021
    Inventors: William E. Brewer, Kaylee R. Mastrianni
  • Patent number: 11054412
    Abstract: Exhaled breath analysis in health and disease is an area of growing clinical interest with the potential to be adopted through the whole respiratory healthcare continuum. However, currently there is no standard for exhaled breath collection, and the optimal way to preconcentrate the highly humid exhaled breath is not known. Described is an optimized combination of sorbent materials and sample handling methods that allows quantitative capturing of exhaled molecules over a broad range in highly humid conditions. The invention can be applied in pre-concentration units of future devices for exhaled breath analysis, for example at the bedside.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: July 6, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Hugo Hubertus Knobel, Ruud Johannes Theodorus Soers, Tamara Mathea Elisabeth Nijsen, Johannes Weda
  • Patent number: 11020737
    Abstract: A pipette tip (20) containing a rigid porous matrix (22) on which a ligand is immobilized, the ligand being capable of binding to a protein associated with chromatin; the rigid porous matrix being positioned within the pipette tip such that, in use, chromatin in a liquid sample passing through the pipette tip is retained by the rigid porous matrix is described. A method of isolating chromatin from the liquid sample using the pipette tip and the use of the pipette tip in a chromatin immunoprecipitation assay are also described.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: June 1, 2021
    Assignee: Porvair Filtration Group Limited
    Inventors: David Richard Cowieson, Samantha Jane Hutchinson, Lewis Francis
  • Patent number: 11009434
    Abstract: Disclosed is a method of supported liquid extraction (SLE), wherein adsorption of at least one analyte to a solid phase is performed in the presence of salt. The method may include contacting a sample with salt, adsorption phase such as diatomaceous earth and optionally a subsequent step of phospholipid depletion. Also disclosed is a cartridge including two compartments, for salt and adsorption phase, and optionally a third compartment including a phospholipid depletion phase.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: May 18, 2021
    Assignee: BIOTAGE AB
    Inventor: Sung Baek
  • Patent number: 10856790
    Abstract: Transdermally emitted gasses are detected by applying a dermal sampling strip to the skin of a biological subject, capturing the gasses in a vapor space in the dermal sampling strip, and analyzing for at least one such gas captured in the vapor space of the dermal sampling strip. Analysis is preferably performed using an electrocatalytic cell, which can be mounted on the dermal sampling strip and form a wall of the vapor space.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: December 8, 2020
    Assignee: Exhalix LLC
    Inventors: Alireza Shekarriz, Debra May Friedrichsen
  • Patent number: 10850281
    Abstract: A nucleic acid analysis apparatus with isothermal based amplification includes a chamber, a fluid delivery unit, a thermal unit, a rotational driven unit and at least one optical unit. The chamber includes a cartridge mounted therein. The fluid delivery unit is connected with the chamber and adapted to transport reagents within the cartridge for sample purification and/or nucleic acid extraction. The thermal unit is disposed in the chamber and adapted to provide a predefined temperature for nucleic acid amplification. The rotational driven unit is connected with the chamber and comprises a motion control unit, wherein the motion control unit is capable of pressing the cartridge during sample purification and/or nucleic acid extraction and rotating the cartridge with a predefined program during nucleic acid amplification and/or detection. The at least one optical unit is disposed on the chamber and includes plural optical components for detection.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: December 1, 2020
    Inventor: Qian Liang
  • Patent number: 10768176
    Abstract: The present invention relates to reagents and methods for binding compounds to surfaces that are hydrophobic. More specifically, the invention relates to simple methods for coating of hydrophobic planar, membrane or particle surfaces to facilitate binding of molecules such as labels, dyes, synthetic and biological polymers and/or nanoparticles thereto.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: September 8, 2020
    Inventors: Chang-yi Huang, Nobuyoshi Joe Maeji
  • Patent number: 10703656
    Abstract: A method for producing an ionized water product for coffee comprises the steps of introducing source water to an ionization system, passing the source water through one or more reaction vessels, wherein one or more ionic species are introduced into the source water, and combining products of one or more reaction vessels to produce the ionized water product having between about 10 ppm to about 40 ppm magnesium ions, about 10 ppm to about 40 ppm calcium ions, and about 40 ppm to about 90 ppm total of bicarbonate and carbonate ions.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: July 7, 2020
    Assignee: Pentair Filtration Solutions, LLC
    Inventors: James Cornwell, Zack Schmidt, John Krueger, Brian Sheehan
  • Patent number: 10343160
    Abstract: A cartridge assembly that comprises a housing, including a flow cell chamber to receive a flow cell, and a well plate having liquid wells to receive desired amounts of liquids. The well plate includes a valve station, a pump station and a fluidics analysis station, and channels associated therewith. A pump assembly to manage fluid flow through the channels between the pump station and the fluidics analysis station. A rotary valve assembly that includes a rotor shaft and rotor valve positioned to rotate about a rotational axis and to selectively couple the wells to the pump station. The rotor shaft includes a dual spline configuration at the distal end thereof. The dual spline configuration has first and second sets of splines. The first set of splines forms a drive interface and the second set of splines forms a position encoding interface.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: July 9, 2019
    Inventors: Richard L. Lemoine, James Osmus, Sz-Chin Steven Lin, Beng Keong Ang
  • Patent number: 9627188
    Abstract: This invention relates to systems and methods for measuring quantitatively multiple species or heavy metals, including mercury, and other toxic pollutants. More specifically, the systems and methods of the invention allows for determination of the analytes even at very low concentration, through concentration on a collection interface, desorption and analysis by mass spectrometry. The invention also provides for a portable device or kit for modifying an existing mass spectrometer.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: April 18, 2017
    Assignee: McGill University
    Inventors: Parisa A. Ariya, Farhad Raofie, Daniel Deeds
  • Patent number: 9592507
    Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing including a top portion having a first substantially rigid zone and a substantially flexible zone, a bottom portion separate from the top portion including a second substantially rigid zone, and at least one sensor recess containing a sensor. The top portion and the bottom portion are bonded to form the cartridge having a conduit over at least a portion of the sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: March 14, 2017
    Inventors: Kevin John Doyle, Paul Wilkins, Mick Withers, Adrian Cooper, John Oakey Noell
  • Patent number: 9581578
    Abstract: The utilization of a specific preconcentration protocol within an automated, on-line drinking water analysis method to amplify detection levels of individual halo acetic acids is provided. The proposed sequential injection analysis procedures allow for measuring such levels in drinking water samples from remote locations with post-column reaction of ion chromatography (PCR-IC). The novel remote preconcentration method injects such known concentrations via a syringe at regular intervals in a manner to provide a baseline measurement that accords a reliable comparison with the unknown amounts present within the drinking water samples at issue. In such a manner, the on-line, remote system provides the necessary reliability for a water utility or like entity on which to base any further needed water treatment activities without having to perform such measurements in a distinct lab setting.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: February 28, 2017
    Inventors: Gary L. Emmert, Paul S. Simone, Jr.
  • Patent number: 9440166
    Abstract: A method of extracting an analyte from a sample is described. The sample is added to a sample container. A liquid solvent and a gas are added into the sample container. The addition of the gas is controlled to establish an elevated pressure within the sample container. The liquid solvent is heated to an elevated temperature that is below the boiling temperature of the liquid solvent at the elevated pressure. A type of gas is used that does not transition to a supercritical fluid at the elevated temperature and pressure used in the extraction process. The analyte can dissolve from the solid sample into the liquid solvent. Next, at least a portion of the liquid solvent containing the dissolved analyte can be removed from the sample container for subsequent analysis.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: September 13, 2016
    Inventors: Kannan Srinivasan, SM Rahmat Ullah
  • Patent number: 9429570
    Abstract: The present disclosure utilizes the aggregation of stimuli-responsive polymers to isolate a diagnostic target (e.g., an antigen) from a solution using magnetophoresis. Isolating the diagnostic target provides a route to identify the presence of the diagnostic target in the solution.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: August 30, 2016
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Patrick S. Stayton, Jriuan Lai, Barrett J. Nehilla, Selvi Srinivasan
  • Patent number: 9396918
    Abstract: A sample plate in use with a MALDI-TOF (matrix-assisted laser desorption ionization time-of-flight) mass spectrometer. The sample plate is usable for the mass spectrometry of a polymeric material on the order of several hundreds of Da and a method of manufacturing the same sample plate. The sample plate including a target plate, an organic matrix formed on one surface of the target plate, and a Parylene thin film formed on the target plate on which the organic matrix is formed, the Parylene thin film entirely covering the organic matrix.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: July 19, 2016
    Assignee: University-Industry Foundation(UIF), Yonsei University
    Inventors: Jaechul Pyun, Jo Il Kim
  • Patent number: 9314733
    Abstract: A method for detecting paths and amount of loss of desulfurization organic components in a flue gas desulfurization system includes preparing a to-be-measured solution and a base standard solution, and diluting the base standard solution with water to a plurality of standard solutions containing different concentrations of desulfurization organic components; adjusting the to-be-measured solution and standard solutions to have a strong acidity, respectively, such that each of desulfurization organic components in the to-be-measured solution and standard solutions exists in ion forms; heating and oscillating the to-be-measured solution and standard solutions, respectively; respectively detecting carbon elements in the standard solutions, to form a linear relationship between concentrations of the desulfurization organic components in the standard solutions and detected carbon element data; and detecting carbon elements in the to-be-measured solution, and obtaining a total concentration of the desulfurization or
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: April 19, 2016
    Inventors: Yong Cheng, Jianming Li
  • Patent number: 9254484
    Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: February 9, 2016
    Inventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout, Xuefeng Wang, Kashan Ali Shaikh, Greg Darryl Goddard
  • Patent number: 9175281
    Abstract: The present invention provides process of purification of tissue plasminogen activator (tPA) from a crude mixture or a partially purified mixture containing tPA protein and impurities by using hydrophobic interaction column chromatography, optionally in combination with ion exchange column chromatography.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: November 3, 2015
    Assignee: Cadila Healthcare Limited
    Inventors: Sanjay Bandyopadhyay, Sanjeev Kumar Mendiratta, Sushobhan Bandyopadhyay
  • Patent number: 9150983
    Abstract: Apparatus, methods and systems having first and second imaging stations for processing a specimen collection slide having a specimen adsorbed there-through. The first imaging station having a first camera adjacent a first surface of the sample slide and a first lighting assembly directed at an opposite surface of the slide to capture the first surface image, while the second imaging station has a second camera adjacent the second surface and a second lighting assembly directed at the first slide surface to capture a second surface image. A computing device having sets of instructions receives and analyzes the imaging data from the first and second imaging stations, and identifies a location of the absorbed specimen for removal. A punch removes this identified location of the absorbed specimen on the sample slide.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: October 6, 2015
    Inventor: Thomas W. Astle
  • Patent number: 9145448
    Abstract: The invention provides a method for the isolation of haptoglobin from a sample comprising Cohn fraction V, wherein said method comprises anion exchange chromatography of said sample. The product may be further purified and/or subjected to one or more virus inactivation or reduction steps. The isolated haptoglobin may then be formulated for pharmaceutical use.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: September 29, 2015
    Inventors: Joan Dalton, Adrian Podmore, Peter Kumpalume
  • Patent number: 9140634
    Abstract: A heating and magnet module for a device for the purpose of purifying nucleic acids, having a plate assembly which has a heating plate, and a magnet carrier plate. The heating plate and the magnet carrier plate can be moved vertically relative to each other between two end positions, in opposition to a spring force. A vessel arrangement is placed on the heating plate, having row or matrix form vessels. One magnet of the magnet carrier plate is functionally assigned to each of these.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: September 22, 2015
    Assignee: Analytik Jena AG
    Inventors: Claus Knippschild, Claudia Schiessl
  • Patent number: 9084994
    Abstract: This invention relates to a kit and a method for the collection and analysis of complex protein mixtures. More particularly, the invention relates to a kit comprising a single barrel filtration well or a multi-well filtration plate wherein each well comprises an upper filtration zone; a lower filtration zone; a conical flow director zone; and, an elution tip, wherein the upper filtration zone and the lower filtration zone are separated by a retainer ring disposed within the lower filtration zone. The upper filtration zone comprises an upper collection zone, a sponge zone, and a deep bed filtration zone; and, the lower filtration zone comprises the retainer ring, a supported hydrophilic membrane and a lower bed filtration media. When used with an array of selected buffer solutions, the multi-well filtration plate can provide accurate, automated, high-throughput protein analysis by affinity chromatography.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: July 21, 2015
    Assignees: OROCHEM Technologies, Inc., The Rockefeller University
    Inventors: Asha A. Oroskar, John P. LaCava, Michael Paul Rout, Anil R. Oroskar
  • Patent number: 9034657
    Abstract: A two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location; allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location; and, after a predetermined period of time, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and which is dried on the lateral flow matrix at a location upstream of the sample port delivery of the sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species and bind with any IgE antibody bound to the immobilized IgE antigen species, a
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: May 19, 2015
    Assignee: Phadia AB
    Inventors: Gerd Rundström, Per Matsson, Paul Christopher
  • Patent number: 9034651
    Abstract: This invention relates to methods and apparatus for determination of ion concentrations, particularly in downhole water from hydrocarbon wells, aquifers etc. It is useful in a wide range of applications, including predicting the formation of scale and fingerprinting waters from different sources. More particularly, the invention relates to the use of ligands whose electronic configuration is altered by the binding of the scaling ions within a water sample. These alterations are detected electrochemically by applying varying potential to electrodes and measuring current flow as potential is varied, from which is derived the concentration of scaling ions in the fluid.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: May 19, 2015
    Assignee: Schlumberger Technology Corporation
    Inventors: Li Jiang, Timothy Gareth John Jones, Andrew Meredith, Markus Pagels, Amilra Prasanna De Silva
  • Patent number: 9029162
    Abstract: Disclosed are methods and systems for the analysis of testosterone in a sample using supported liquid extraction and liquid chromatography-mass spectrometry.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: May 12, 2015
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Russell Philip Grant, Matthew Crawford, Donald Walt Chandler, William Curtin
  • Publication number: 20150118676
    Abstract: Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. In one embodiment, an ionic propulsion device for providing a sample for a bio-specific assay of aerosol particles comprises a housing receiving a sample of aerosol particles and enclosing a high voltage electrode to generate a plasma of electrically charged particles. A carrier assembly is removably receivable in the housing, the carrier assembly comprising a non-conductive carrier and an electrode removably secured to the carrier.
    Type: Application
    Filed: August 22, 2014
    Publication date: April 30, 2015
    Inventor: Julian Gordon
  • Patent number: 9017617
    Abstract: Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a second valve at least partially disposed in the first chamber, and a pump comprising an actuator and nozzle.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: April 28, 2015
    Assignee: Luminex Corporation
    Inventors: Jesus Ching, David Hsiang Hu, Steve Jia Chang Yu, Phillip You Fai Lee
  • Patent number: 9012614
    Abstract: Provided is a method for rapid nucleic acid purification. The method includes allowing the nucleic acid isolated from the biological sample to be adsorbed on a silica membrane; separating contaminants from the nucleic acid-adsorbed silica membrane by using paper chromatography; and eluting only high-purity nucleic acid from the silica membrane from which the contaminants are isolated by using a buffer, or applying at least one selected from direct PCR, RT-PCR, real-time PCR, and real-time RT-PCR to the nucleic acid bound onto the silica membrane.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: April 21, 2015
    Assignee: Nanohelix Co., Ltd.
    Inventors: Minsu Ko, Young Cheol Kim, Siseok Lee
  • Publication number: 20150099660
    Abstract: Microfluidic devices and methods for using the same are provided. Aspects of the invention include microfluidic devices that include a separation medium and a pan-capture binding medium. The microfluidic devices are configured to subject a sample to two or more directionally distinct electric fields. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays.
    Type: Application
    Filed: November 7, 2014
    Publication date: April 9, 2015
    Inventors: Amy E. Herr, Dohyun Kim
  • Patent number: 8993333
    Abstract: Disclosed is a method of providing a risk evaluation and diagnosis of human cancer, by examining the presence, in the volatile fraction of a human saliva sample, of a combination of particulate biochemical volatile organic compounds, which is indicative of an increased risk of developing cancer.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: March 31, 2015
    Assignee: Institut Clinident
    Inventor: Franck Chaubron
  • Publication number: 20150087025
    Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
    Type: Application
    Filed: December 3, 2014
    Publication date: March 26, 2015
    Inventors: Kristopher Barbee, Maximilian Carpino, Ray Wheeling, Nicholas Peter Bajka
  • Patent number: 8978896
    Abstract: An apparatus filters particles from small volumes of liquid in a tubular vial having an open top and closed bottom with a tubular plunger sliding in the vial to force liquid through a filter at the end of the plunger and into a cavity in the plunger. The filter is held by a cap placed over the end of the plunger. The vial's bottom has an upward extending protrusion mating with a conforming recess in the cap to direct liquid to the protraction and filter as the cap abuts the bottom of the vial. Channels in the bottom help direct liquid flow.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: March 17, 2015
    Assignee: Scientific Plastic Products, Inc.
    Inventors: Samuel A. Ellis, Kishan G. Hingorani
  • Patent number: 8974734
    Abstract: An electronic nose device is disclosed in an embodiment of the invention. The electronic nose device includes a fan module, a gas molecule sensor module, a control unit and an output unit. The fan module is used to pump air actively to the gas molecule sensor module. The gas molecule sensor module detects the air pumped into by the fan module. The gas molecule sensor module at least includes a gas molecule sensor which is covered with a compound. The compound is used to combine preset gas molecules. The control unit controls the fan module to suck air into the electronic nose device. Then the fan module transmits an air current to the gas molecule sensor module to generate a detected data. The output unit calculates the detected data to generate a calculation result and outputs an indicating signal to an operator or compatible host computer according to the calculation result.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: March 10, 2015
    Assignee: EPS Bio Technology Corp.
    Inventors: Jun-Hao Tian, Jian-Hua Chen, Chi-Zuo Chu, Wei-Jen Ho, Li-Jin Kang, Yu-Lun Wang, Meng-Erh Li
  • Patent number: 8969026
    Abstract: Methods for liquid-liquid extraction, as can be effected using polymeric reverse micelles, such methods as can be used in conjunction with various mass spectrometric techniques.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: March 3, 2015
    Assignee: University of Massachusetts
    Inventors: Sankaran Thayumanavan, Richard Vachet, Elamprakash N. Savariar, Marianny Y. Combariza
  • Patent number: 8962343
    Abstract: The invention relates to a process and a device for parallel fractionating a multiplicity of individual samples (29) within a 3-dimensional separation medium (6), with the subsequent process steps being carried out: A first space (2) which extends essentially across all three space coordinates contains the separation medium (6). A multiplicity of individual samples (29) is arranged close to an interface of the first space (2), with the individual samples (29) being arranged essentially in a planar fashion, i.e. their particular center-of-gravity positions are described by two coordinates. Under the influence of one or more physical parameters, the individual samples (29) are able to migrate essentially perpendicularly to the area of their application through the separation medium (6), and are fractionated in the process according to one or more of their properties.
    Type: Grant
    Filed: March 5, 2003
    Date of Patent: February 24, 2015
    Inventors: Robert Alexander Ventzki, Josef Stegemann
  • Publication number: 20150037903
    Abstract: A lab-on-chip-based system is described for the direct and multiple sampling, control of the volume, fluid filtration, biochemical reactions, sample transfer, and dried spot generation on the conventional and commercial cards for dried fluid spot. Within an all-in-one integrated holder, the invention allows the complete process required to ensure a quantitative analysis of blood, plasma or any other fluids, modification and enrichment of molecule subsets, and formation of a dried fluid spot on the specific spot location of a passive cellulose, non-cellulose, absorbent, or non-absorbent membrane material sampling.
    Type: Application
    Filed: March 7, 2013
    Publication date: February 5, 2015
    Inventors: Didier Maillefer, Julien Deglon, Aurelien Thomas, Julien Dumont
  • Patent number: 8945932
    Abstract: The invention provides methods for detecting and isolating phosphomolecules using phosphoaffinity materials that comprise a hydrated metal oxide. In an embodiment, a method for detecting a phosphomolecule in a sample involves (a) contacting a sample with a phosphoaffinity material comprising a hydrated metal oxide, under conditions wherein a phosphomolecule is capable of binding to the phosphoaffinity material to form a phosphomolecule-phosphoaffinity material complex, and (b) detecting formation of a phosphomolecule-phosphoaffinity material complex, thereby detecting a phosphomolecule in the sample.
    Type: Grant
    Filed: July 6, 2005
    Date of Patent: February 3, 2015
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Wayne F. Patton, Alvydas Mikulskis, Eva Golenko
  • Patent number: 8940542
    Abstract: A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: January 27, 2015
    Assignee: Lighthouse Medical Limited
    Inventors: William Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
  • Publication number: 20150024511
    Abstract: A solid phase for use in separation has been modified using an aqueous phase adsorption of a headgroup-modified lipid to generate analyte specific surfaces for use as a stationary phase in separations such as high performance liquid chromatography (HPLC) or solid phase extraction (SPE). The aliphatic moiety of the lipid adsorbs strongly to a hydrophobic solid surface, with the hydrophilic and active headgroups orienting themselves toward the more polar mobile phase, thus allowing for interactions with the desired solutes. The surface modification approach is generally applicable to a diversity of selective immobilization applications such as protein immobilization clinical diagnostics and preparative scale HPLC as demonstrated on capillary-channeled fibers, though the general methodology could be implemented on any hydrophobic solid support material.
    Type: Application
    Filed: July 17, 2014
    Publication date: January 22, 2015
    Inventors: R. Kenneth Marcus, Kenneth A. Christensen