Including Use Of A Solid Sorbent, Semipermeable Membrane, Or Liquid Extraction Patents (Class 436/178)
  • Patent number: 10343160
    Abstract: A cartridge assembly that comprises a housing, including a flow cell chamber to receive a flow cell, and a well plate having liquid wells to receive desired amounts of liquids. The well plate includes a valve station, a pump station and a fluidics analysis station, and channels associated therewith. A pump assembly to manage fluid flow through the channels between the pump station and the fluidics analysis station. A rotary valve assembly that includes a rotor shaft and rotor valve positioned to rotate about a rotational axis and to selectively couple the wells to the pump station. The rotor shaft includes a dual spline configuration at the distal end thereof. The dual spline configuration has first and second sets of splines. The first set of splines forms a drive interface and the second set of splines forms a position encoding interface.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: July 9, 2019
    Assignees: ILLUMINA, INC., ILLUMINA, SINGAPORE PTE. LTD.
    Inventors: Richard L. Lemoine, James Osmus, Sz-Chin Steven Lin, Beng Keong Ang
  • Patent number: 9627188
    Abstract: This invention relates to systems and methods for measuring quantitatively multiple species or heavy metals, including mercury, and other toxic pollutants. More specifically, the systems and methods of the invention allows for determination of the analytes even at very low concentration, through concentration on a collection interface, desorption and analysis by mass spectrometry. The invention also provides for a portable device or kit for modifying an existing mass spectrometer.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: April 18, 2017
    Assignee: McGill University
    Inventors: Parisa A. Ariya, Farhad Raofie, Daniel Deeds
  • Patent number: 9592507
    Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing including a top portion having a first substantially rigid zone and a substantially flexible zone, a bottom portion separate from the top portion including a second substantially rigid zone, and at least one sensor recess containing a sensor. The top portion and the bottom portion are bonded to form the cartridge having a conduit over at least a portion of the sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: March 14, 2017
    Assignee: ABBOTT POINT OF CARE INC.
    Inventors: Kevin John Doyle, Paul Wilkins, Mick Withers, Adrian Cooper, John Oakey Noell
  • Patent number: 9581578
    Abstract: The utilization of a specific preconcentration protocol within an automated, on-line drinking water analysis method to amplify detection levels of individual halo acetic acids is provided. The proposed sequential injection analysis procedures allow for measuring such levels in drinking water samples from remote locations with post-column reaction of ion chromatography (PCR-IC). The novel remote preconcentration method injects such known concentrations via a syringe at regular intervals in a manner to provide a baseline measurement that accords a reliable comparison with the unknown amounts present within the drinking water samples at issue. In such a manner, the on-line, remote system provides the necessary reliability for a water utility or like entity on which to base any further needed water treatment activities without having to perform such measurements in a distinct lab setting.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: February 28, 2017
    Inventors: Gary L. Emmert, Paul S. Simone, Jr.
  • Patent number: 9440166
    Abstract: A method of extracting an analyte from a sample is described. The sample is added to a sample container. A liquid solvent and a gas are added into the sample container. The addition of the gas is controlled to establish an elevated pressure within the sample container. The liquid solvent is heated to an elevated temperature that is below the boiling temperature of the liquid solvent at the elevated pressure. A type of gas is used that does not transition to a supercritical fluid at the elevated temperature and pressure used in the extraction process. The analyte can dissolve from the solid sample into the liquid solvent. Next, at least a portion of the liquid solvent containing the dissolved analyte can be removed from the sample container for subsequent analysis.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: September 13, 2016
    Assignee: DIONEX CORPORATION
    Inventors: Kannan Srinivasan, SM Rahmat Ullah
  • Patent number: 9429570
    Abstract: The present disclosure utilizes the aggregation of stimuli-responsive polymers to isolate a diagnostic target (e.g., an antigen) from a solution using magnetophoresis. Isolating the diagnostic target provides a route to identify the presence of the diagnostic target in the solution.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: August 30, 2016
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Patrick S. Stayton, Jriuan Lai, Barrett J. Nehilla, Selvi Srinivasan
  • Patent number: 9396918
    Abstract: A sample plate in use with a MALDI-TOF (matrix-assisted laser desorption ionization time-of-flight) mass spectrometer. The sample plate is usable for the mass spectrometry of a polymeric material on the order of several hundreds of Da and a method of manufacturing the same sample plate. The sample plate including a target plate, an organic matrix formed on one surface of the target plate, and a Parylene thin film formed on the target plate on which the organic matrix is formed, the Parylene thin film entirely covering the organic matrix.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: July 19, 2016
    Assignee: University-Industry Foundation(UIF), Yonsei University
    Inventors: Jaechul Pyun, Jo Il Kim
  • Patent number: 9314733
    Abstract: A method for detecting paths and amount of loss of desulfurization organic components in a flue gas desulfurization system includes preparing a to-be-measured solution and a base standard solution, and diluting the base standard solution with water to a plurality of standard solutions containing different concentrations of desulfurization organic components; adjusting the to-be-measured solution and standard solutions to have a strong acidity, respectively, such that each of desulfurization organic components in the to-be-measured solution and standard solutions exists in ion forms; heating and oscillating the to-be-measured solution and standard solutions, respectively; respectively detecting carbon elements in the standard solutions, to form a linear relationship between concentrations of the desulfurization organic components in the standard solutions and detected carbon element data; and detecting carbon elements in the to-be-measured solution, and obtaining a total concentration of the desulfurization or
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: April 19, 2016
    Assignee: PANGANG GROUP PANZHIHUA IRON & STEEL RESEARCH INSTITUTE CO., LTD
    Inventors: Yong Cheng, Jianming Li
  • Patent number: 9254484
    Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: February 9, 2016
    Assignee: WHATMAN INTERNATIONAL LIMITED
    Inventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout, Xuefeng Wang, Kashan Ali Shaikh, Greg Darryl Goddard
  • Patent number: 9175281
    Abstract: The present invention provides process of purification of tissue plasminogen activator (tPA) from a crude mixture or a partially purified mixture containing tPA protein and impurities by using hydrophobic interaction column chromatography, optionally in combination with ion exchange column chromatography.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: November 3, 2015
    Assignee: Cadila Healthcare Limited
    Inventors: Sanjay Bandyopadhyay, Sanjeev Kumar Mendiratta, Sushobhan Bandyopadhyay
  • Patent number: 9150983
    Abstract: Apparatus, methods and systems having first and second imaging stations for processing a specimen collection slide having a specimen adsorbed there-through. The first imaging station having a first camera adjacent a first surface of the sample slide and a first lighting assembly directed at an opposite surface of the slide to capture the first surface image, while the second imaging station has a second camera adjacent the second surface and a second lighting assembly directed at the first slide surface to capture a second surface image. A computing device having sets of instructions receives and analyzes the imaging data from the first and second imaging stations, and identifies a location of the absorbed specimen for removal. A punch removes this identified location of the absorbed specimen on the sample slide.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: October 6, 2015
    Inventor: Thomas W. Astle
  • Patent number: 9145448
    Abstract: The invention provides a method for the isolation of haptoglobin from a sample comprising Cohn fraction V, wherein said method comprises anion exchange chromatography of said sample. The product may be further purified and/or subjected to one or more virus inactivation or reduction steps. The isolated haptoglobin may then be formulated for pharmaceutical use.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: September 29, 2015
    Assignee: BIO PRODUCTS LABORATORY LIMITED
    Inventors: Joan Dalton, Adrian Podmore, Peter Kumpalume
  • Patent number: 9140634
    Abstract: A heating and magnet module for a device for the purpose of purifying nucleic acids, having a plate assembly which has a heating plate, and a magnet carrier plate. The heating plate and the magnet carrier plate can be moved vertically relative to each other between two end positions, in opposition to a spring force. A vessel arrangement is placed on the heating plate, having row or matrix form vessels. One magnet of the magnet carrier plate is functionally assigned to each of these.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: September 22, 2015
    Assignee: Analytik Jena AG
    Inventors: Claus Knippschild, Claudia Schiessl
  • Patent number: 9084994
    Abstract: This invention relates to a kit and a method for the collection and analysis of complex protein mixtures. More particularly, the invention relates to a kit comprising a single barrel filtration well or a multi-well filtration plate wherein each well comprises an upper filtration zone; a lower filtration zone; a conical flow director zone; and, an elution tip, wherein the upper filtration zone and the lower filtration zone are separated by a retainer ring disposed within the lower filtration zone. The upper filtration zone comprises an upper collection zone, a sponge zone, and a deep bed filtration zone; and, the lower filtration zone comprises the retainer ring, a supported hydrophilic membrane and a lower bed filtration media. When used with an array of selected buffer solutions, the multi-well filtration plate can provide accurate, automated, high-throughput protein analysis by affinity chromatography.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: July 21, 2015
    Assignees: OROCHEM Technologies, Inc., The Rockefeller University
    Inventors: Asha A. Oroskar, John P. LaCava, Michael Paul Rout, Anil R. Oroskar
  • Patent number: 9034651
    Abstract: This invention relates to methods and apparatus for determination of ion concentrations, particularly in downhole water from hydrocarbon wells, aquifers etc. It is useful in a wide range of applications, including predicting the formation of scale and fingerprinting waters from different sources. More particularly, the invention relates to the use of ligands whose electronic configuration is altered by the binding of the scaling ions within a water sample. These alterations are detected electrochemically by applying varying potential to electrodes and measuring current flow as potential is varied, from which is derived the concentration of scaling ions in the fluid.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: May 19, 2015
    Assignee: Schlumberger Technology Corporation
    Inventors: Li Jiang, Timothy Gareth John Jones, Andrew Meredith, Markus Pagels, Amilra Prasanna De Silva
  • Patent number: 9034657
    Abstract: A two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location; allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location; and, after a predetermined period of time, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and which is dried on the lateral flow matrix at a location upstream of the sample port delivery of the sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species and bind with any IgE antibody bound to the immobilized IgE antigen species, a
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: May 19, 2015
    Assignee: Phadia AB
    Inventors: Gerd Rundström, Per Matsson, Paul Christopher
  • Patent number: 9029162
    Abstract: Disclosed are methods and systems for the analysis of testosterone in a sample using supported liquid extraction and liquid chromatography-mass spectrometry.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: May 12, 2015
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Russell Philip Grant, Matthew Crawford, Donald Walt Chandler, William Curtin
  • Publication number: 20150118676
    Abstract: Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. In one embodiment, an ionic propulsion device for providing a sample for a bio-specific assay of aerosol particles comprises a housing receiving a sample of aerosol particles and enclosing a high voltage electrode to generate a plasma of electrically charged particles. A carrier assembly is removably receivable in the housing, the carrier assembly comprising a non-conductive carrier and an electrode removably secured to the carrier.
    Type: Application
    Filed: August 22, 2014
    Publication date: April 30, 2015
    Inventor: Julian Gordon
  • Patent number: 9017617
    Abstract: Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a second valve at least partially disposed in the first chamber, and a pump comprising an actuator and nozzle.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: April 28, 2015
    Assignee: Luminex Corporation
    Inventors: Jesus Ching, David Hsiang Hu, Steve Jia Chang Yu, Phillip You Fai Lee
  • Patent number: 9012614
    Abstract: Provided is a method for rapid nucleic acid purification. The method includes allowing the nucleic acid isolated from the biological sample to be adsorbed on a silica membrane; separating contaminants from the nucleic acid-adsorbed silica membrane by using paper chromatography; and eluting only high-purity nucleic acid from the silica membrane from which the contaminants are isolated by using a buffer, or applying at least one selected from direct PCR, RT-PCR, real-time PCR, and real-time RT-PCR to the nucleic acid bound onto the silica membrane.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: April 21, 2015
    Assignee: Nanohelix Co., Ltd.
    Inventors: Minsu Ko, Young Cheol Kim, Siseok Lee
  • Publication number: 20150099660
    Abstract: Microfluidic devices and methods for using the same are provided. Aspects of the invention include microfluidic devices that include a separation medium and a pan-capture binding medium. The microfluidic devices are configured to subject a sample to two or more directionally distinct electric fields. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays.
    Type: Application
    Filed: November 7, 2014
    Publication date: April 9, 2015
    Inventors: Amy E. Herr, Dohyun Kim
  • Patent number: 8993333
    Abstract: Disclosed is a method of providing a risk evaluation and diagnosis of human cancer, by examining the presence, in the volatile fraction of a human saliva sample, of a combination of particulate biochemical volatile organic compounds, which is indicative of an increased risk of developing cancer.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: March 31, 2015
    Assignee: Institut Clinident
    Inventor: Franck Chaubron
  • Publication number: 20150087025
    Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
    Type: Application
    Filed: December 3, 2014
    Publication date: March 26, 2015
    Inventors: Kristopher Barbee, Maximilian Carpino, Ray Wheeling, Nicholas Peter Bajka
  • Patent number: 8978896
    Abstract: An apparatus filters particles from small volumes of liquid in a tubular vial having an open top and closed bottom with a tubular plunger sliding in the vial to force liquid through a filter at the end of the plunger and into a cavity in the plunger. The filter is held by a cap placed over the end of the plunger. The vial's bottom has an upward extending protrusion mating with a conforming recess in the cap to direct liquid to the protraction and filter as the cap abuts the bottom of the vial. Channels in the bottom help direct liquid flow.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: March 17, 2015
    Assignee: Scientific Plastic Products, Inc.
    Inventors: Samuel A. Ellis, Kishan G. Hingorani
  • Patent number: 8974734
    Abstract: An electronic nose device is disclosed in an embodiment of the invention. The electronic nose device includes a fan module, a gas molecule sensor module, a control unit and an output unit. The fan module is used to pump air actively to the gas molecule sensor module. The gas molecule sensor module detects the air pumped into by the fan module. The gas molecule sensor module at least includes a gas molecule sensor which is covered with a compound. The compound is used to combine preset gas molecules. The control unit controls the fan module to suck air into the electronic nose device. Then the fan module transmits an air current to the gas molecule sensor module to generate a detected data. The output unit calculates the detected data to generate a calculation result and outputs an indicating signal to an operator or compatible host computer according to the calculation result.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: March 10, 2015
    Assignee: EPS Bio Technology Corp.
    Inventors: Jun-Hao Tian, Jian-Hua Chen, Chi-Zuo Chu, Wei-Jen Ho, Li-Jin Kang, Yu-Lun Wang, Meng-Erh Li
  • Patent number: 8969026
    Abstract: Methods for liquid-liquid extraction, as can be effected using polymeric reverse micelles, such methods as can be used in conjunction with various mass spectrometric techniques.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: March 3, 2015
    Assignee: University of Massachusetts
    Inventors: Sankaran Thayumanavan, Richard Vachet, Elamprakash N. Savariar, Marianny Y. Combariza
  • Patent number: 8962343
    Abstract: The invention relates to a process and a device for parallel fractionating a multiplicity of individual samples (29) within a 3-dimensional separation medium (6), with the subsequent process steps being carried out: A first space (2) which extends essentially across all three space coordinates contains the separation medium (6). A multiplicity of individual samples (29) is arranged close to an interface of the first space (2), with the individual samples (29) being arranged essentially in a planar fashion, i.e. their particular center-of-gravity positions are described by two coordinates. Under the influence of one or more physical parameters, the individual samples (29) are able to migrate essentially perpendicularly to the area of their application through the separation medium (6), and are fractionated in the process according to one or more of their properties.
    Type: Grant
    Filed: March 5, 2003
    Date of Patent: February 24, 2015
    Inventors: Robert Alexander Ventzki, Josef Stegemann
  • Publication number: 20150037903
    Abstract: A lab-on-chip-based system is described for the direct and multiple sampling, control of the volume, fluid filtration, biochemical reactions, sample transfer, and dried spot generation on the conventional and commercial cards for dried fluid spot. Within an all-in-one integrated holder, the invention allows the complete process required to ensure a quantitative analysis of blood, plasma or any other fluids, modification and enrichment of molecule subsets, and formation of a dried fluid spot on the specific spot location of a passive cellulose, non-cellulose, absorbent, or non-absorbent membrane material sampling.
    Type: Application
    Filed: March 7, 2013
    Publication date: February 5, 2015
    Inventors: Didier Maillefer, Julien Deglon, Aurelien Thomas, Julien Dumont
  • Patent number: 8945932
    Abstract: The invention provides methods for detecting and isolating phosphomolecules using phosphoaffinity materials that comprise a hydrated metal oxide. In an embodiment, a method for detecting a phosphomolecule in a sample involves (a) contacting a sample with a phosphoaffinity material comprising a hydrated metal oxide, under conditions wherein a phosphomolecule is capable of binding to the phosphoaffinity material to form a phosphomolecule-phosphoaffinity material complex, and (b) detecting formation of a phosphomolecule-phosphoaffinity material complex, thereby detecting a phosphomolecule in the sample.
    Type: Grant
    Filed: July 6, 2005
    Date of Patent: February 3, 2015
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Wayne F. Patton, Alvydas Mikulskis, Eva Golenko
  • Patent number: 8940542
    Abstract: A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: January 27, 2015
    Assignee: Lighthouse Medical Limited
    Inventors: William Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
  • Publication number: 20150024511
    Abstract: A solid phase for use in separation has been modified using an aqueous phase adsorption of a headgroup-modified lipid to generate analyte specific surfaces for use as a stationary phase in separations such as high performance liquid chromatography (HPLC) or solid phase extraction (SPE). The aliphatic moiety of the lipid adsorbs strongly to a hydrophobic solid surface, with the hydrophilic and active headgroups orienting themselves toward the more polar mobile phase, thus allowing for interactions with the desired solutes. The surface modification approach is generally applicable to a diversity of selective immobilization applications such as protein immobilization clinical diagnostics and preparative scale HPLC as demonstrated on capillary-channeled fibers, though the general methodology could be implemented on any hydrophobic solid support material.
    Type: Application
    Filed: July 17, 2014
    Publication date: January 22, 2015
    Inventors: R. Kenneth Marcus, Kenneth A. Christensen
  • Patent number: 8936944
    Abstract: A method and apparatus for managing a zone. Information is obtained about an environment in the zone with a sensor system. A determination is made by an analyzer system as to whether a contagious condition is present in the zone using the information from the sensor system. An action is performed by a management system in response to the contagious condition being present.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: January 20, 2015
    Assignee: The Boeing Company
    Inventors: Leora Peltz, Shawn Hyunsoo Park
  • Patent number: 8932864
    Abstract: Provided is a method and device for identifying glycated protein in a sample using a matrix including a boronic acid moiety that binds glycated proteins.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: January 13, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Sang-kyu Kim, Sung-ha Park, Kyung-mi Song, Soo-suk Lee, Youn-suk Choi
  • Publication number: 20150011016
    Abstract: A pipette tip device for use in dispersive SPE. The device includes a pipette tip having a lower barrier, loose sorbent that is freely moveable during the extraction process, and a baffle system that is shaped to disrupt the flow of liquid sample that is aspirated into the pipette tip. The baffle system includes an insert that may be separate from or monolithic with the interior of the pipette tip.
    Type: Application
    Filed: February 14, 2013
    Publication date: January 8, 2015
    Inventor: William E. Brewer
  • Patent number: 8926903
    Abstract: To perform accurate measurement in the analysis of chemical components with low concentration, pretreatment such as concentration and purification of samples is essential. For high-throughput of pretreatment of biological samples, various random clinical testing is encountered, where analytes change from sample to sample. The pretreatment apparatus has a separating agent selectively separating a specific component by allowing a sample solution to flow therethrough. A holding section holds a plurality of housing sections, which house the separating agent therein, and has an endless track. A pressurizing section applies pressure to the housing section in a continuous and random-accessible manner; and an extraction solution receiver mechanism selectively receives an extracted solution from the separating agent housed in the housing section. A mass spectrometer is that can be connected to the pretreatment apparatus. Thus, a large number of specimens can be simultaneously processed.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: January 6, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Makoto Nogami, Katsuhiro Kanda, Izumi Waki
  • Patent number: 8925734
    Abstract: A filter vial and piston are provided where the vial has a cylindrical wall with a closed bottom and open top and with the hollow, tubular piston therein. The piston has a distal end covered by a cup having a proximal cup seal extending outward to engage the walls of the vial to form a fluid tight seal with the vial during use. The distal end of the piston has a piston flange extending outwardly and located adjacent a recess in the piston so the cup forms a snap fit over the piston flange and extends into the recess. The piston flange causes the cup to bulge sufficiently outward to form a fluid tight seal with the vial during use. A filter is placed in the bottom of the cup and abuts an inwardly extending lip on the cup. The filter is held against the lip by a piston support at the distal end of the piston. A cup support at a distal end of the cup also helps support the filter.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: January 6, 2015
    Assignee: Scientific Plastic Products, Inc.
    Inventors: Samuel A. Ellis, Kishan G. Hingorani
  • Patent number: 8920658
    Abstract: Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis. The liquid eluent is pumped through a heated nebulizer to create a high-speed jet of solute containing liquid and solvent vapor. This jet is directed circumferentially inside a hot cylindrical cavity. Centrifugal force causes the larger liquid droplets to travel along the outer diameter of the cavity. The cavity surface is heated to cause the droplets to film boil. Film boiling reduces droplet contact with the cavity surface thereby retaining the solute in the droplets. The solute temperature is limited by controlling the pressure into which the solvent evaporates from the droplets.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: December 30, 2014
    Assignee: Spectra Analysis Instruments, Inc.
    Inventors: William W. Carson, Sidney Bourne
  • Publication number: 20140370508
    Abstract: This invention pertains to a method of preparing biological material from a biological sample selected from the group consisting of blood and sputum samples. The method includes the step of altering at least one constitutive characteristic of the biological sample in the presence of a capturing scaffold by adding a lysis buffer containing a solubilising agent and a detergent to the biological sample, for simultaneously inhibiting coagulation of the biological sample; lysing the biological sample to release the biological material from the biological sample, thus making the biological material available; and capturing at least one fraction of the biological material on the capturing scaffold.
    Type: Application
    Filed: September 6, 2012
    Publication date: December 18, 2014
    Applicant: North-West University
    Inventors: Anne Frederica Grobler, Oksana Levanets
  • Publication number: 20140363897
    Abstract: A method is provided for enhancing the binding of reagents to ligands. In the method a ligand is immobilized on a porous support and incubated with a reagent solution. The binding of the reagent to the ligand is increased by a cycling process of passing the reagent solution through the support multiple times. A device that facilitates the cycling process is disclosed. The invention also provides a method to detect multiple ligands using the cycling process.
    Type: Application
    Filed: June 10, 2013
    Publication date: December 11, 2014
    Inventor: Yingjian Wang
  • Publication number: 20140356976
    Abstract: A sorptive extraction layer for immobilized liquid extraction of target molecules preferably from biological samples is disclosed. The sorptive extraction layer is mainly composed of ethylene-acrylate-copolymer. Preferably, microplate wells are at least partially coated with such a sorptive extraction layer. There is also disclosed a method of extracting target molecules preferably from biological samples. According to this method, immobilized liquid extraction is carried out with a sorptive extraction layer which is mainly composed of ethylene-acrylate-copolymer.
    Type: Application
    Filed: June 4, 2013
    Publication date: December 4, 2014
    Inventor: Robert WOHLEB
  • Patent number: 8900875
    Abstract: A method for assessing a corrosion inhibitor in a coolant, comprises providing a test kit comprising a first chamber containing an acid buffer and a solvent immiscible therein and a second chamber containing an indicator, the second chamber being in fluid communication with the first chamber and being configured such that retraction of the second chamber draws fluid into the first chamber and advancement forces fluid into the second chamber; drawing a coolant sample into the first chamber; contacting the coolant sample with the acid buffer and solvent in the first chamber and extracting the corrosion inhibitor into the solvent; allowing the solvent and buffer to separate in the first chamber; forcing a portion of the separated solvent into the second chamber; contacting the separated solvent with the indicator in the second chamber, and obtaining a visual indication of the presence of corrosion inhibitor in the coolant sample.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: December 2, 2014
    Assignee: Shell Oil Company
    Inventors: Abraham Robert De Kraker, Liliana Minevski, Tze Lee Phang
  • Publication number: 20140342373
    Abstract: The present invention concerns a microfluidic system comprising: a microchannel containing several elements of two non-miscible fluids, the microchannel comprising a droplet (30) containing magnetic particles (M), and a device for generating inside the microchannel magnetic field, said device comprising an activable magnetic element, the activable magnetic element comprising a tip (5,6), the microfluidic system being configured to transport the droplet by flow or by pressure difference.
    Type: Application
    Filed: July 24, 2012
    Publication date: November 20, 2014
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jean-Louis Viovy, Laurent Malaquin, Stefano Begolo, AnaïS Ali Cherif, Stephanie Descroix
  • Patent number: 8865475
    Abstract: A method for making a number (N) of samples react under the same reaction conditions that includes heating a number of reaction containers simultaneously and maintaining the reaction containers at a predetermined temperature; placing a sample in each heated reaction chamber and maintaining a two-phase solution at a predetermined temperature; stirring the sample that is heated to the predetermined temperature to create a uniform solution, which is maintained for a predetermined time; and cooling the uniform solution without cooling the reaction container after the predetermined period of time has passed so as to gain a two-phase solution within the reaction container, where the samples have a solution where the phase state of a reaction solvent changes in a reversible manner between a two-phase solution state and a uniform solution state when the temperature fluctuates over or under a certain constant temperature.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: October 21, 2014
    Assignee: Japan Science and Technology Agency
    Inventor: Kazuhiro Chiba
  • Publication number: 20140302617
    Abstract: A sample collection system capable of collecting, storing and dispensing a liquid sample is disclosed. The collection system includes a collector composed of a material which has the unique ability to express constituents of interest at levels which are much more concentrated than their levels in the fluid samples from which they are expressed, where the expressed highly concentrated sample can then be used with modern rapid screening/testing protocols, such as solid phase assays, to test for the constituents of interest. Thus, it is now possible to obtain analytes of interest, such as the HIV protein antibodies, from saliva samples at concentrations that are detectable with systems and/or devices that are typically utilized only for blood serum or plasma testing. The collector is sized and shaped to fit within a recovery container, which, in turn, is sized and shaped to fit within a collection tube.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 9, 2014
    Inventor: JACK L. ARONOWITZ
  • Patent number: 8852444
    Abstract: The present teachings provide, in part, methods of separating two-dimensional nanomaterials by atomic layer thickness. In certain embodiments, the present teachings provide methods of generating graphene nanomaterials having a controlled number of atomic layer(s).
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: October 7, 2014
    Assignee: Northwestern University
    Inventors: Alexander A. Green, Mark C. Hersam
  • Publication number: 20140295420
    Abstract: The invention relates to means for processing a sample fluid containing different components, particularly magnetic particles (M) and targets (cells) (C+M) labeled with magnetic particles. A processing device (100) according to the invention comprises a container (110) with a first compartment (120) that can be filled with a sample fluid and that is separated from a second compartment (130) by a filtering element (140). The filtering element (140) allows the passage of only at least one selected component (M) of the sample. Moreover, an optical surface (150), for example a microscopy slide, is provided in one (120) of the compartments. Components (C+M) of the sample that are in this compartment (120) collect on the optical surface (150). The migration of sample components (M, C+M) is preferably assisted by magnetic fields (B1, B2).
    Type: Application
    Filed: June 14, 2012
    Publication date: October 2, 2014
    Inventors: Mikhail Mikhaylovich Ovsyanko, Freek Van Hemert, Menno Willem Jose Prins, Anja Van De Stolpe, Reinhold Wimberger Friedl
  • Publication number: 20140248714
    Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 4, 2014
    Applicant: WHATMAN INTERNATIONAL LIMITED
    Inventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout, Xuefeng Wang, Kashan Ali Shaikh, Greg Darryl Goddard
  • Publication number: 20140242718
    Abstract: A pretreatment device applied in sampling and providing a reaction space for biochemical reaction is disclosed. The pretreatment device includes a quantitative sampler being capable of collecting a constant volume of a sample; a devastating device having a hollow cylindrical structure coupled to the quantitative sampler to damage a thin-film like protective membrane of the quantitative sampler such that the reaction reagent flows out of the reagent container; a reaction device having a tubular structure and providing the reaction space for biochemical reaction of the reaction reagent and the sample; a hollow ring-shaped structure to position and stable the connection of the devastating device and the quantitative sampler with the hollow ring-shaped structure being coupled to the reaction device; and an anti-drain device preventing the reaction reagent and the sampler from flowing out before the biochemical reaction is completed.
    Type: Application
    Filed: July 23, 2013
    Publication date: August 28, 2014
    Inventor: Ying-Ho HWANG
  • Publication number: 20140220701
    Abstract: A device (1) for extracting an extraction material, in particular for solid-phase micro-extraction, comprises an extractor (130) and a tip (100) for penetrating a separating layer, wherein the extractor (130) is connected to the tip (100). In a method for extracting an extraction material from a container with an extraction device (1), a separating layer of the container is penetrated by a tip (100) of an extractor (130), and the extraction material is extracted.
    Type: Application
    Filed: February 4, 2014
    Publication date: August 7, 2014
    Applicant: CTC Analytics AG
    Inventors: Kai Heinrich SCHUELER, Christophe SCHILLIG
  • Patent number: RE45274
    Abstract: The present invention relates generally to molecularly imprinted polymers (MIPs). In particular, the present invention relates to reusable, ecologically friendly MIPs that can be produced in relatively large quantities, methods of producing the same, and methods of utilizing the same (e.g., to sequester and/or adsorb target compounds (e.g., mycotoxins)). Compositions and methods of the invention find use in a variety of applications including dietary therapeutic, prophylactic, food and beverage processing and manufacture, as well as research, quality control and traceability applications.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: December 2, 2014
    Assignee: Alltech, Inc.
    Inventors: Alexandros Yiannikouris, Stefan Kwiatkowski, Manoj Bojappa Kudupoje, Clayton Matney