Cellulose Or Derivative Patents (Class 436/530)
  • Patent number: 10048256
    Abstract: Sample analysis systems and methods are provided.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: August 14, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Jan zur Megede
  • Patent number: 10023335
    Abstract: The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises levan.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: July 17, 2018
    Assignee: Ferring B.V.
    Inventors: Shweta Gupta, Varinder Ahuja, Tejas Gunjikar, Kristin Wannerberger
  • Patent number: 10017583
    Abstract: Disclosed herein is an improved process for the preparation of nanostructured oxidized/carboxy cellulose with high carboxy content and high yield, by subjecting non-wood, lignocellulose, sugarcane bagasse derived a-cellulose or cotton cellulose to oxidation at suitable temperature, wherein the particle shape is spherical, particle size of synthesized carboxy cellulose is in the range of 1-100 nm and degree of polymerization (DP) is in the range 50-70 Further the present invention provides pharmaceutical composition comprising of nanostructured oxidized/carboxy celluloses preferably 6-carboxy cellulose, and 2,3,6-tricarboxycellulose alone or in association with one or more pharmaceutically acceptable carrier(s) or excipient(s) for treatment of microbial infections. The carboxycelluloses were efficient in stabilizing multi-walled carbon nanotubes and single-walled carbon nanotubes in aqueous media.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: July 10, 2018
    Assignee: Council of Scientific & Industrial Research
    Inventors: Anjanikumar Jyotiprasad Varma, Priyanka Radheyshyam Sharma, Dhiman Sarkar
  • Patent number: 9868974
    Abstract: The present invention relates to a sensor device for measuring a level of an analyte of interest in a fluid, such as body fluid (for example blood, plasma, urine, interstitial fluid, saliva), a method of manufacturing a sensor device, a reagent film for use in a sensor, a method of manufacturing a reagent film for use in a sensor, a method of conducting an assay using a sensor, a method of calibrating a measurement from a sensor, a method of calibrating a batch of sensors, a meter for use with a sensor and a kit comprising a meter and a sensor according to the invention. A first aspect of the invention provides a sensor device for measuring a level of an analyte of interest In a fluid comprising: a flowpath for the fluid; on the flowpath, a reagent for the analyte of interest adjacent to an internal standard comprising a first predetermined amount of a first calibration analyte; and further wherein the reagent and the predetermined amount of a first calibration analyte are in dry form.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: January 16, 2018
    Assignee: SureSensors Ltd.
    Inventor: Geoffrey Frank Hall
  • Patent number: 9562908
    Abstract: Provided are an immunochromatography kit that is highly sensitive and capable of multicoloration, and organic colored microparticles that are ideal as an element of the immunochromatography kit. Organic colored microparticles having an average grain size between 10 and 1,000 nm and a color intensity between 1.0 and 5.0 are prepared using cellulose as the starting material. When the organic colored microparticles are used as a label in an immunochromatography kit, the immunochromatography kit is of a high sensitivity than conventional technology. The immunochromatography kit is also capable of multicoloration and is useful for rapid diagnosis.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: February 7, 2017
    Assignee: ASAHI KASEI FIBERS CORPORATION
    Inventors: Satoru Yoshida, Yoshiyuki Shiomi, Toshihiko Matsui, Masanori Doi, Nobuyuki Mimura, Takeshi Matsuse
  • Patent number: 9034657
    Abstract: A two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location; allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location; and, after a predetermined period of time, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and which is dried on the lateral flow matrix at a location upstream of the sample port delivery of the sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species and bind with any IgE antibody bound to the immobilized IgE antigen species, a
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: May 19, 2015
    Assignee: Phadia AB
    Inventors: Gerd Rundström, Per Matsson, Paul Christopher
  • Patent number: 8999728
    Abstract: The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device is a pregnancy test device, which detects human chorionic gonadotropin (hCG) as an indicator of pregnancy. Devices with improved clinical sensitivity are provided which are capable of detecting all clinically relevant hCG isoforms.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: April 7, 2015
    Assignee: Church & Dwight Co., Inc.
    Inventors: Albert R. Nazareth, Shang Li
  • Patent number: 8993299
    Abstract: The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: March 31, 2015
    Assignee: Novozymes A/S
    Inventors: Lene Lange, Wenping Wu, Dominique Aubert, Sara Landvik, Kirk Matthew Schnorr, Ib Groth Clausen
  • Patent number: 8986969
    Abstract: The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: March 24, 2015
    Assignee: Novozymes A/S
    Inventors: Lene Lange, Wenping Wu, Dominique Aubert, Sara Landvik, Kirk Matthew Schnorr, Ib Groth Clausen
  • Publication number: 20150031145
    Abstract: Compositions, methods, articles of manufacture, and kits are provided for storage and delivery of proteins.
    Type: Application
    Filed: July 24, 2014
    Publication date: January 29, 2015
    Inventors: Clayton T. McKee, William Strong
  • Patent number: 8916389
    Abstract: An object of the present invention is to provide an element for SPR measurement without the need of a mechanical solution-sending mechanism.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: December 23, 2014
    Assignee: Nippon Telegraph and Telephone Corporation
    Inventors: Yuzuru Iwasaki, Michiko Seyama, Toru Miura, Tsutomu Horiuchi, Tsuneyuki Haga, Serge Camou
  • Patent number: 8906703
    Abstract: A method for immobilizing an amino-containing material to a substrate is described. The method involves providing a tethering compound with two reactive groups: a substrate reactive group and a fluoroalkoxycarbonyl group. The method further involves preparing a substrate-attached tethering group by reacting the substrate reactive group of the tethering compound with a complementary functional group on the surface of a substrate. The substrate-attached tethering group has a fluoroalkoxycarbonyl group that can be reacted with an amino-containing material to form an immobilization group that connects the amino-containing material to the substrate.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: December 9, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Karl E. Benson, Charles M. Leir, George G. I. Moore, Rahul R. Shah
  • Patent number: 8889835
    Abstract: The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: November 18, 2014
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg, Chien-Hsing Chang
  • Patent number: 8821810
    Abstract: The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.
    Type: Grant
    Filed: February 3, 2011
    Date of Patent: September 2, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Whitesides, Katherine A. Mirica, Andres W. Martinez, Chao-Min Cheng, Scott T. Phillips, Monica Mascareñas, Xinyu Liu, Xiujun Li
  • Patent number: 8614101
    Abstract: Devices and methods incorporate lysis agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters a lysis agent. The lysis agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the initially lysis agent is localized between the sample application zone and the conjugate zone. The lysis agent is preferably soluble or miscible in the sample transport liquid, and the lysis agent is solubilized and activated upon contact with the sample transport liquid. The sample transport liquid then contains both lysis agent in solution or suspension and sample components in suspension. Any lysis-susceptible components in a sample, then being exposed in suspension to the lysis agent, are themselves lysed in situ. The running buffer then carries the analyte, including any lysis-freed components, to the detection zone.
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: December 24, 2013
    Assignee: Rapid Pathogen Screening, Inc.
    Inventors: Robert W. VanDine, Uma Mahesh Babu, Robert P. Sambursky
  • Patent number: 8603793
    Abstract: The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: December 10, 2013
    Assignee: Novozymes A/S
    Inventors: Lene Lange, Wenping Wu, Dominique Aubert, Sara Landvik, Kirk Matthew Schnorr, Ib Groth Clausen
  • Patent number: 8603832
    Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: December 10, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Whitesides, Scott T. Phillips, Andreas W. Martinez, Manish J. Butte, Amy Wong, Samuel W. Thomas, Hayat Sindi, Sarah J. Vella, Emanuel Carrilho, Katherine A. Mirica, Yanyan Liu
  • Patent number: 8603794
    Abstract: The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: December 10, 2013
    Assignee: Novozymes A/S
    Inventors: Lene Lange, Wenping Wu, Dominique Aubert, Sara Landvik, Kirk Matthew Schnorr, Ib Groth Clausen
  • Patent number: 8569073
    Abstract: A test element, for example in the form of an immunological test strip functioning according to the sandwich principle, for the fluorophoric detection of one or more analytes in a sample comprising an analyte detection zone and a combined control and calibration zone. The combined control and calibration zone include a fluorophore and binding partners for the specific binding of reagents labelled with a fluorophore. Furthermore, the invention concerns a method for calibrating an analyte-specific measurement signal, a method for determining the concentration of an analyte in a sample and the use of the test element for calibrating a signal generated in the analyte detection zone of a test element.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: October 29, 2013
    Assignee: Roche Diagnostics Operations Inc.
    Inventor: Thomas Fischer
  • Patent number: 8563330
    Abstract: The invention provides a device and method for the rapid identification of patients suspected of having thalassemia. The invention provides a test strip for the aqueous detection of thalassemia related proteins in whole blood. The test strip includes antibodies specific to the gamma 4, (?4) protein and provides easy visual discrimination between a positive result and a negative result. The invention can be used in remote or clinical settings.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: October 22, 2013
    Assignee: National Science and Technology Development Agency
    Inventors: Watchara Kasinrerk, Chatchai Tayapiwatana, Thanusak Tatu, Suthat Fucharoen, Sawitree Chiampanichayakul
  • Patent number: 8524507
    Abstract: A method is provided for detecting a target molecule in a biological sample. One step of the method includes immobilizing the biological sample on a membrane. Next, the membrane-bound biological sample is contacted with at least one detection moiety. The membrane-bound biological sample is then separately mated with a substrate and the target molecule detected. At least one step of the method is performed under positive pressure or a vacuum.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: September 3, 2013
    Assignee: The Cleveland Clinic Foundation
    Inventor: David J. Kennedy
  • Patent number: 8513028
    Abstract: The present invention relates to novel uses of the MLN 51 gene or protein. The MLN 51 gene and protein is closely related to the development of rheumatoid arthritis and serve as biomarker and therapeutic target for rheumatoid arthritis, particularly chronic synovitis.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: August 20, 2013
    Assignee: Creagene Inc.
    Inventors: Jin Ah Jang, Dae Seog Lim, Hyun Soo Lee, Yong Soo Bae
  • Patent number: 8507238
    Abstract: The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: August 13, 2013
    Assignee: Novozymes A/S
    Inventors: Lene Lange, Wenping Wu, Dominique Aubert, Sara Landvik, Kirk Matthew Schnorr, Ib Groth Clausen
  • Patent number: 8501497
    Abstract: The present invention generally relates to methods of constructing liquid bridges and methods of forming predetermined combinations of samples using liquid bridges.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: August 6, 2013
    Assignee: Stokes Bio Limited
    Inventors: Mark Davies, Tara Dalton
  • Patent number: 8501495
    Abstract: A sequential solid phase immunoassay and system is disclosed. The immunoassay utilizes the secondary antibody method for the detection of antibodies in a membrane-based test. The system comprises a test strip including a nitrocellulose membrane having an immobilized antigen in a capture zone on the membrane and a stabilized liquid secondary antibody conjugate. The sequential solid phase immunoassay is performed in a sequential manner with the addition of a fluid specimen being followed by the addition of the stabilized liquid secondary antibody conjugate. The sequential procedure using the system includes allowing the fluid specimen containing antibodies specific to the antigen to pass laterally from the test strip first end through the capture zone. The immobilized antigens in the capture zone capture antibodies specific to the antigen. The stabilized liquid secondary antibody conjugate then binds to the captured antibodies and can be detected visually or by a machine or reader.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: August 6, 2013
    Assignee: Equal Access to Scientific Excellence
    Inventors: Kai Ling Yao, Peter Chun
  • Patent number: 8476082
    Abstract: Devices and methods for the detection of target molecules are disclosed. Devices and methods for detecting food-borne target molecules are also disclosed.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: July 2, 2013
    Assignee: Invisible Sentinel, Inc.
    Inventors: Nicholas A. Siciliano, Martin Joseph Bouliane
  • Patent number: 8455265
    Abstract: A surface grafted conjugated polyelectrolyte (CPE) is formed by coupling a CPE by a coupling moiety to the surface of a substrate. The substrate can be of any shape and size, and for many uses of the surface grafted CPE, it is advantageous that the substrate is a nanoparticle or microparticle. Surface grafted CPEs are presented that use silica particles as the substrate, where a modified silane coupling agent connects the surface to the CPE by a series of covalent bonds. Two methods of preparing the surface grafted CPEs are presented. One method involves the inclusion of the surface being modified by the coupling agent and condensed with monomers that form the CPE in a grafted state to the substrate. A second method involves the formation of a CPE with terminal groups that are complimentary to functionality that has been placed on the surface of the substrate by reaction with a coupling agent. The surface grafted CPEs are also described for use as biosensors and biocides.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: June 4, 2013
    Assignee: STC.UNM
    Inventors: David G. Whitten, Sireesha Chemburu, Thomas Corbitt, Linnea Ista, Gabriel Lopez, Kirk S. Schanze, Motokatsu Ogawa, Eunkyung Ji
  • Patent number: 8445293
    Abstract: The present invention includes methods and devices for preventing interfering substances from affecting the accuracy of a lateral flow immunoassay. In preferred embodiments, a test strip includes a capturing zone that includes at least one mobile capturing reagent that separates at least one interfering substance from the analyte. The capturing zone is preferably located upstream of the sample application zone. In some embodiments, the reagent/conjugate zone is also located upstream of the sample application zone. The capturing zone may be located upstream, downstream, or overlapping with the reagent/conjugate zone in these embodiments. In other preferred embodiments, one or more mobile capturing reagents are included in the elution medium/running buffer. In yet other embodiments, the capturing reagent is incorporated into a sample collection device of a sample collection system, preferably separate from the chromatographic test strip. A lysis zone is also included in some preferred embodiments.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: May 21, 2013
    Assignee: Rapid Pathogen Screening, Inc.
    Inventors: Uma Mahesh Babu, Franz Aberl, Marcus Scheibenzuber, Robert P. Sambursky, Robert W. VanDine, Jose S. Sambursky
  • Publication number: 20130065256
    Abstract: An assay apparatus comprising: i) an assay cartridge (52, 53) comprising at least one well (57-62) and a pipette (50) positionable in at least one said well; ii) a holder arranged to received said cartridge; iii) drive means operable to position said pipette in selected wells of said cartridge; iv) a gas pressure applicator couplable to said pipette whereby to cause liquid flow through said membrane; and v) a radiation detector operable to detect radiation from a well of said cartridge of said cartridge or from said pipette.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 14, 2013
    Applicant: AXIS-SHIELD AS
    Inventors: Jostein HOLTLUND, Stig Morten Borch, Thorstein Seim, Tore Janson, Hege Tøn, Jan Roger Karlson, Inger Lise Lauvstad
  • Patent number: 8394600
    Abstract: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, a method for immobilizing a lipoidal antigen, comprising cardiolipin, lecithin, and cholesterol, on a solid support (such as a nitrocellulose membrane) is described. The ability to immobilize a lipoidal antigen on a membrane satisfies a long-felt need for a membrane-based assay for the detection of anti-lipoidal antibodies. Also described are immunoassay devices for concurrently performing treponemal and non-treponemal tests for syphilis.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: March 12, 2013
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
    Inventor: Arnold R. Castro
  • Patent number: 8394626
    Abstract: The present invention includes but is not limited to a specimen collection device that includes a chamber capable of collecting a specimen, a specimen passage slot, a reservoir, a reservoir seal, and a test device. A sample or specimen added to the chamber flows through the specimen passage slot into the reservoir. Flow into the reservoir may be limited by the reservoir seal. The test device positioned within the reservoir detects the presence or concentration of an analyte within the sample or specimen.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: March 12, 2013
    Assignee: Alere Switzerland GmbH
    Inventors: James T. Ramsey, Larry Hartselle
  • Patent number: 8389229
    Abstract: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, a method for immobilizing a lipoidal antigen, comprising cardiolipin, lecithin, and cholesterol, on a solid support (such as a nitrocellulose membrane) is described. The ability to immobilize a lipoidal antigen on a membrane satisfies a long-felt need for membrane-based assay for the detection of anti-lipoidal antibodies. Also described are immunoassay devices for concurrently performing treponemal and non-treponemal tests for syphilis.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: March 5, 2013
    Assignee: The United States of America as Represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
    Inventors: Arnold R. Castro, Robert W. George
  • Patent number: 8377710
    Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: February 19, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Whitesides, Scott T. Phillips, Andres W. Martinez, Manish J. Butte, Amy Wong, Samuel W. Thomas, Hayat Sindi, Sarah J. Vella, Emanuel Carrilho, Katherine A. Mirica, Yanyan Liu
  • Patent number: 8372660
    Abstract: This invention discloses an analyzing method for detecting a specific analyte in a fluid sample. The method comprises the following steps. First, a substrate is provided. The substrate has a channel provided concavely on an upper surface thereof. The channel comprises a first area, a second area and a third area, and these three areas are connected sequentially. Each of the second and the third areas comprises a nitrocellulose layers containing a reaction material and formed at the bottom thereof. The nitrocellulose layer of the third area can absorb a fixed volume of the fluid sample. Second, the fluid sample is applied to the first area and delivered by the second area and then to the third area. Finally, the reaction material reacts with the specific analyte in the fluid sample to produce a signal for detection.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: February 12, 2013
    Assignee: Actherm Inc
    Inventors: Wen-Pin Hsieh, Yi-Jen Wu
  • Patent number: 8338156
    Abstract: The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: December 25, 2012
    Assignee: Novozymes A/S
    Inventors: Lene Lange, Wenping Wu, Dominique Aubert, Sara Landvik, Kirk Matthew Schnorr, Ib Groth Clausen
  • Patent number: 8268636
    Abstract: The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: September 18, 2012
    Assignee: Church & Dwight Co., Inc.
    Inventors: Albert Nazareth, Timothy Snowden, Yea-shun Cheng
  • Patent number: 8241574
    Abstract: An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: August 14, 2012
    Assignee: Smart Holograms Limited
    Inventors: Barry Burles, Roger Bradley Millington, Christopher Robin Lowe, Satyamoorthy Kabilan, Jeffrey Blyth
  • Patent number: 8236575
    Abstract: A first reactant, which is provided with a reaction site for specific binding with an analyte, and a fluorescent label site, and a second reactant, which is provided with a reaction site for specific binding with the analyte, and a fluorescence recognition site for recognizing fluorescence produced by the fluorescent label site of the first reactant, are respectively fixed onto a support such that the first reactant and the second reactant have a positional relationship adapted for the binding with the analyte.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: August 7, 2012
    Assignee: FUJIFILM Corporation
    Inventors: Koichi Minami, Hirohiko Tsuzuki
  • Patent number: 8206992
    Abstract: Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making the same are described. A diagnostic system includes a hydrophilic loading thread having an inlet zone at a proximal end; a testing zone at a distal end; and an intermediate zone located between the inlet zone and the testing zone, wherein the testing zone does not directly contact the inlet zone. In another aspect, a diagnostic system includes (i) a hydrophilic loading thread that includes an inlet zone at a proximal end and an intermediate zone at a distal end; and (ii) one or more additional hydrophilic threads that contact the intermediate zone of the loading thread.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: June 26, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: Meital Reches, Michael D. Dickey, Manish J. Butte, George M. Whitesides
  • Patent number: 8202734
    Abstract: A test device and method for determining the presence or absence of an analyte in a fluid sample, the test device including a support bearing a mark thereon, and a matrix defining an axial flow path. In operation, an observation area in the test device becomes transparent, thereby allowing the user to view a mark that is present on a support that is disposed beneath the observation area. Typically, the mark on the underlying support is configured as a minus (?) sign. In the absence of analyte in the sample, the test device presents a negative result as a minus (?) signal. In the presence of analyte in the sample, however, the mark operates in concert with a perpendicular test line on the observation area to present a positive result as a plus (+) signal that is visible to the user.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: June 19, 2012
    Assignee: Quidel Corporation
    Inventors: Jeremy Jerome, Mark Daquipa, Bruce Jacono, Hans Boehringer
  • Patent number: 8192997
    Abstract: The invention provides methods for treatment of acute coronary syndrome and prediction of adverse cardiac events on the basis of elevations of catalytic iron in biological fluid of a human subject. An embodiment of the invention provides a method for early detection of acute coronary syndrome (ACS) in a human subject at the time of presentation of the chest pain. The method includes analyzing a test sample of the biological fluid for amount of catalytic iron and detecting acute coronary syndrome in the human subject.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: June 5, 2012
    Inventors: Mohan Rajapurkar, Suhas Lele, Sudhir Shah
  • Patent number: 8183059
    Abstract: Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: May 22, 2012
    Assignee: Invisible Sentinel, Inc.
    Inventors: Nicholas A. Siciliano, Martin Joseph Bouliane
  • Patent number: 8168446
    Abstract: A diagnostic and testing apparatus and related methods for the use of the same are disclosed which derive and use antibodies to equine albumin and equine hemoglobin in testing apparatus, kits, and methods for detecting and localizing gastric and colonic ulcers or bleeding in horses. Fecal droppings from a horse to be tested are placed in a container together with a buffered liquid solution and mixed thoroughly, following which several drops of liquid from the container are placed into a test kit. Visual markers in the test kits signify the detection of the indicators equine hemoglobin and equine albumin, which are respectively indicative of the presence of gastric and/or colonic ulcers or bleeding.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: May 1, 2012
    Assignee: Freedom Health, LLC
    Inventors: Franklin L. Pellegrini, Scott D. Carter
  • Patent number: 8153444
    Abstract: A chromatographic specific binding assay strip device, comprising: a non-permeable platform strip; a permeable membrane testing strip positioned on top of said non-permeable platform strip, with the testing strip comprising at least one capture reagent site containing a capture reagent for at least one specific analyte, a sample receiving pad positioned on top of and at a proximal end of the non-permeable platform strip, with the sample receiving pad having contact with a proximal end of said permeable membrane testing strip, a reservoir pad positioned on top of and at a distal end of said non-permeable membrane testing strip, with the reservoir pad having contact with a proximal end of said permeable membrane test strip; a supporting strip attached to and extending from the proximal end of said non-permeable platform strip; and a conjugate pad positioned on said supporting strip, said conjugate pad comprising a semi-permeable membrane containing a colorant conjugate.
    Type: Grant
    Filed: March 18, 2009
    Date of Patent: April 10, 2012
    Assignee: Auric Enterprises, LLC
    Inventors: Leslie Kirkegaard, Glen Ford
  • Patent number: 8133718
    Abstract: An analytical strip and a detecting method using the analytical strip are provided. The analytical strip includes a substrate having a channel thereon. The channel has a first region, a second region and a third region, which are arranged successively. A first antibody is localized in the first region. A saccharide and a peroxidase are localized in the first or second region. A second antibody for recognizing a different epitope of an identical antigen with the first antibody is immobilized in the second region. A substrate reagent including a saccharide oxidase is localized in the third region.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: March 13, 2012
    Assignee: Actherm Inc
    Inventors: Yi-Jen Wu, Chih-Wei Hsieh, Wen-Pin Hsieh
  • Patent number: 8119420
    Abstract: Providing an absorption pad which shows remarkable water absorptivity and can shorten a detection time when employed for an immunoassay apparatus. A water absorption pad for the immunoassay apparatus, containing 50% by weight or more of silicon-containing particles wherein a moisture absorptivity is 30% or less at a humidity of 60% or less and a moisture absorptivity is 40% or more at a humidity of 90% or more, a strip for an immunoassay using said absorption pad as a suction part, and an immunoassay apparatus including said strip for the immunoassay.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: February 21, 2012
    Assignee: Fujirebio Inc.
    Inventors: Chisato Okamura, Minoru Sato
  • Patent number: 8105843
    Abstract: Methods and devices for rapid lateral flow immunoassays to detect specific antibodies within a liquid sample while also validating the adequacy of the liquid sample for the presence of immunoglobulin and the integrity and immunoreactivity of the test reagents that detect the antibodies of interest, without requiring instrumentation. The methods and devices provide for delivery of a diluted liquid sample to a single location that simultaneously directs the liquid flow along two or more separate flow paths, one that serves as a positive control to confirm that all critical reagents of the test are immunoreactive, and that the sample being tested is adequate, and the other to detect specific antibodies if present.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: January 31, 2012
    Inventor: Thomas M. Buchanan
  • Patent number: 8039268
    Abstract: An immunochromatoassay method that allows high detection sensitivity measurement. The method including the steps of: permeating an analyte solution that includes a visibly labeled second binding substance that specifically binds to a detection target substance into a test area of a chromatography medium provided with a first binding substance that specifically binds to the detection target substance, simultaneously with or after the permeation of the analyte solution into the test area, permeating a visual recognition aid solution into the chromatograph medium, the solution having a refractive index whose refractive index difference ?n from that of the chromatograph medium is ?0.1??n?0.1, and visually observing the test area while the visual recognition aid solution is permeated in the test area.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: October 18, 2011
    Assignee: FUJIFILM Corporation
    Inventor: Hisashi Ohtsuka
  • Patent number: 8030091
    Abstract: A test device and method for determining the presence or absence of one or more analytes in a fluid sample, the test device including a support or member bearing a mark thereon, and a matrix or member containing a capture zone. In operation, an observation area in the test device becomes transparent, thereby allowing the user to view a mark that is present on a support that is disposed beneath the observation area. Typically, the mark on the underlying support is configured as a minus (?) sign. In the absence of analyte in the sample, the test device presents a negative result as a minus (?) signal. In the presence of analyte in the sample, however, the mark operates in concert with a perpendicular test line on the observation area to present a positive result as a plus (+) signal that is visible to the user.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: October 4, 2011
    Assignee: Quidel Corporation
    Inventors: Jeremy Jerome, Mark Daquipa, Bruce Jacono, Hans Boehringer, Paul Lambotte, Paul J. Lawrence
  • Patent number: 8012770
    Abstract: Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: September 6, 2011
    Assignee: Invisible Sentinel, Inc.
    Inventors: Nicholas A. Siciliano, Martin Joseph Bouliane