Involving An Insoluble Carrier For Immobilizing Immunochemicals Patents (Class 436/518)
  • Patent number: 11896975
    Abstract: The invention having functional vertical disposable reaction systems having a vertically mounted semipermeable membrane for sample preparation, chemical reactions, dialysis, enzymatic/microbiological fermentation, multistage processes, in vitro protein biosynthesis on a laboratory scale, formed from a base body and an exchangeable lid having different functions. For exchange across the membrane, the system is placed vertically into an outer volume consisting of gas, liquid or solid constituents. The system consists of a dimensionally stable base body and a liquid-tight lid having a functional support going toward the base of the base body, the dimensionally stable base body forming at least one noncapillary reaction space as inner volume with at least one semipermeable membrane as lateral wall. The high flexibility in use results from the combination of variants of the base bodies with different lid variants for different areas of use.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: February 13, 2024
    Assignee: Scienova GmbH
    Inventors: Stefan Kreusch, Thomas Richter, Raffael Rubick
  • Patent number: 11867692
    Abstract: A colorimetric sensor for detecting bacteria and/or viruses includes one or more layers having a photonic crystal structure, a functional layer comprising a nanomaterial capable of generating bacteria- and/or viruses-bioresponsive surface plasmon overlapping the one or more layers having the photonic crystal structure. The bacteria- and/or viruses-bioresponsive nanomaterial of the functional layer is doped with proteinic substances or antibodies acting as virus receptors, or the colorimetric sensor comprises a receptor layer comprising proteinic substances or antibodies acting as virus receptors. The functional layer and receptor layer overlap each other. Alternatively, or in addition to, the colorimetric sensor comprises a plasmonic nanostructured layer comprising nanostructures such to generate plasmonic colors, overlapping the one or more layers having the photonic crystal structure.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: January 9, 2024
    Assignee: DG GROUP S.P.A.
    Inventor: Dino Radice
  • Patent number: 11772097
    Abstract: A blood sample collection and/or storage device includes a two-piece housing that encompasses a port at which a fingertip blood sample is collected. After the sample is taken, the two-piece housing is moved to a closed position to protect the sample for storage and optionally process the sample within the housing. The housing may also be opened to access the stored sample for further processing.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: October 3, 2023
    Assignee: RENEGADEXBIO, PBC
    Inventor: Brandon T. Johnson
  • Patent number: 11697117
    Abstract: Methods for detecting target analytes utilizing an array of wells are advantageous for detection of low concentrations of target analytes. Use of an array of wells requires sealing of the wells. The methods provided herein utilize digital microfluidics to seal wells of an array with a fluid that is immiscible with the aqueous liquid present in the wells to prevent evaporation and contamination of the aqueous fluid during analysis of signals from the wells. The disclosed method include generating a biphasic droplet composed of the immiscible fluid and an aqueous fluid. The immiscible fluid present in the biphasic droplet is moved over the array of wells to seal the wells by electrically actuating the aqueous fluid present in the biphasic droplet which in turn pulls the immiscible fluid.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: July 11, 2023
    Assignees: Abbott Laboratories, The Katholieke Universiteit Leuven
    Inventors: Mark A. Hayden, Karen Leirs, Elena Pérez-Ruiz, Jeroen Lammertyn
  • Patent number: 11651840
    Abstract: A system, device, and method for predicting a docked position of a target ligand in a binding site of a biomolecule is disclosed. The prediction makes use of a template ligand-biomolecule complex structure in order to predict a target ligand-biomolecule complex structure. The system and device contain modules allowing for the prediction of a target-ligand biomolecule complex structure. A preparation module can receive information identifying a target ligand and a template ligand-biomolecule structure. A pharmacophore matcher module can identify common pharmacophores between the template ligand and the target ligand. A docking module can predict a docked ligand position of the target ligand by overlapping the pharmacophore models of the target ligand and template ligand while the template ligand is in the binding site of the biomolecule. A biomolecule modification module can modify the biomolecule to reduce clashes between the docked target ligand and the biomolecule.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: May 16, 2023
    Assignee: Schrödinger, Inc.
    Inventor: Edward Blake Miller
  • Patent number: 11622750
    Abstract: The disclosed apparatus, systems and methods relate to devices, systems and methods for the collection of bodily fluids. The collector can make use of microfluidic networks connected to collection sites on the skin of a subject to gather and shuttle blood into a removable cartridge. The collected fluid is supplied to substrate for drying, storage and transport.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: April 11, 2023
    Assignee: Tasso, Inc.
    Inventors: Ben Moga, Ben Casavant, Erwin Berthier
  • Patent number: 11613567
    Abstract: Described herein are Notch-modulating peptides (including monomers and multimers) capable of increasing or decreasing an immune response in a subject, compositions comprising the peptides, and methods of use thereof.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: March 28, 2023
    Assignee: Ohio State Innovation Foundation
    Inventors: Thomas J. Magliery, Mikhail M. Dikov, David Carbone, Nicholas Long, Brandon Sullivan, Elena Tchekneva
  • Patent number: 11592415
    Abstract: The present invention relates to an interdigitated microelectrode biosensor using the reaction between receptors and target biomaterials, the interdigitated microelectrode biosensor comprising: an insulating layer formed so as to cover all of the sensor formation area of a substrate; a first interdigitated microelectrode formed such that a plurality of first protruding electrodes are arranged in a comb shape on the insulating layer of the substrate; a second interdigitated microelectrode, facing the first interdigitated microelectrode and formed such that a plurality of second protruding electrodes are arranged in a comb shape on the insulating layer of the substrate such that the plurality of second protruding electrodes are arranged to respectively interdigitate with the plurality of first protruding electrodes formed at the first interdigitated microelectrode; and a plurality of receptors arranged in the space between the first and second interdigitated microelectrodes, which are arranged to interdigitate
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: February 28, 2023
    Assignee: Korea Institute of Science and Technology
    Inventors: Kyo Seon Hwang, Young Soo Kim, Jin Sik Kim, Yong Kyoung Yoo
  • Patent number: 11585787
    Abstract: A detection device, a detecting method for the detection device, and a detecting system are provided. The detection device includes: a first interdigital transducer and a second interdigital transducer, wherein the first interdigital transducer is arranged opposite to the second interdigital transducer, and a surface wave of the first interdigital transducer is transmitted in a direction toward the second interdigital transducer; and a reaction layer arranged between the first interdigital transducer and the second interdigital transducer.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: February 21, 2023
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventor: Yingyi Li
  • Patent number: 11567071
    Abstract: The disclosed devices for lateral flow testing may include a receptacle for receiving bodily fluids from a patient that has a predetermined fluid volume for application to one or more lateral flow test strips. A test strip holder may be positioned to receive the predetermined fluid volume of the bodily fluids from the receptacle. Various other components, devices, and methods are also disclosed.
    Type: Grant
    Filed: October 6, 2021
    Date of Patent: January 31, 2023
    Assignee: FRESENIUS MEDICAL CARE HOLDINGS, INC.
    Inventors: Eric David Bergman, Daniel Lewis Sloat, Jonathan Fitzmaurice Leclerc, Rachel Lauren Bartels
  • Patent number: 11506674
    Abstract: Disclosed are an immunochemical assay device and a method of using the immunochemical assay device for detecting one or more targets or markers such as Cardiac Troponin I, NT-pro-BNP, D-dimer and/or cross-linked fibrin in a fluid sample.
    Type: Grant
    Filed: February 17, 2018
    Date of Patent: November 22, 2022
    Assignee: Princeton BioMeditech Corporation
    Inventors: Jemo Kang, Jin Yang
  • Patent number: 11480564
    Abstract: The present invention relates to a kit for the detection of urease and to a tool and a composition forming part of the kit. In particular, the present invention relates to a kit for the detection of urease which comprises a composition containing an indicator; a delivery tool arranged to deliver a tissue sample into contact with the composition; and urea carried on the delivery tool, whereby the urea is arranged to be delivered to the composition together with the tissue sample.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: October 25, 2022
    Assignee: Infagen (Hong Kong) Limited
    Inventor: Barry Marshall
  • Patent number: 11426733
    Abstract: A sample carrier for assaying can include a plurality of pins having a surface that is capable of picking up at least one substance on the surface. The pins can be arranged such that one or more of the plurality of pins are introduced into a corresponding reaction vessel of a microplate. The sample carrier can be divided into a plurality of modules, with each of the plurality of modules comprising one or more pins of the plurality of pins. Methods of use include placing the sample carrier onto a microplate so that at least the one or more of the plurality of pins extend into the corresponding reaction vessel of the microplate.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: August 30, 2022
    Inventor: Zhaoqiang Wang
  • Patent number: 11422136
    Abstract: The disclosure generally relates to the detection of symmetrical dimethylarginine (SDMA). More particularly, the disclosure relates to the detection of SDMA using a solid phase. The disclosure provides devices, reagents, kits and methods for detecting symmetrical dimethyl arginine (SDMA) in sample, such as a biological sample from an animal. The method includes detecting the presence or amount of SDMA in the sample by using an immunoassay format, such as a competitive immunoassay. The assay includes the use of antibodies to SDMA that are specific for SDMA and that have less affinity for other arginine derivatives.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: August 23, 2022
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Hongzhi Xie, Sreenivasa Rao Ramisetty, Murthy V S N Yerramilli
  • Patent number: 11420941
    Abstract: Provided herein are molecules and salts thereof, arrays containing molecules and salts thereof, solid supports containing molecules and salts thereof, kits containing molecules or salts thereof, and methods of determining alignment of photolithographic masks comprising molecules or salts thereof.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: August 23, 2022
    Assignee: COWPER SCIENCES INC.
    Inventors: Robert Kuimelis, Gaurav Saini, David Smith, Tommy Armsby
  • Patent number: 11402390
    Abstract: The present invention relates to a reliable method of prediction of lower respiratory tract infection or inflammation in humans, wherein the level of pancreatic stone protein/regenerating protein (PSP/reg) is determined in serum, and a high level is indicative of the development and the severity of the disease, allowing the classification of patients according to risk.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: August 2, 2022
    Assignees: UNIVERSITY HOSPITAL OF BASEL, Lascco SA
    Inventors: Daiana Stolz, Frederic Lajaunias
  • Patent number: 11371086
    Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.
    Type: Grant
    Filed: September 21, 2021
    Date of Patent: June 28, 2022
    Assignee: Prognosys Biosciences, Inc.
    Inventor: Mark S. Chee
  • Patent number: 11365441
    Abstract: Provided herein are methods and systems for the simultaneous targeted detection and sequencing of DNA, RNA, and Protein. In typical embodiments, the DNA, RNA, and Proteins are detected, characterized, and sequenced using just a single mammalian cell. One embodiment of detecting and characterizing DNA, RNA, or protein from a mammalian cell includes encapsulating a single cell in a drop and performing a protease digest on the encapsulated cell drop, performing a reverse transcriptase reaction; performing a droplet merger with barcoding PCR reagents and barcoding beads; performing a PCR reaction to attach the cell barcodes to the DNA targeted amplicons, RNA targeted amplicons, and protein tag amplicons, where all amplicons from the same emulsion contain the same cell barcode; and detecting and characterizing a DNA, RNA, or protein amplicon by sequencing the cell barcode incorporated into each amplicon.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: June 21, 2022
    Assignee: Mission Bio, Inc.
    Inventors: Dalia Dhingra, Aik Ooi, Pedro Mendez, David Ruff
  • Patent number: 11360091
    Abstract: A method for diagnosing acute coronary syndrome (ACS) in a subject, the method comprising measuring plasma macrophage migration inhibitory factor (MIF) concentration in a sample from the subject, and diagnosing ACS when the subject plasma MIF concentration is greater than a reference plasma MIF concentration, wherein the sample is taken less than 4 hours after symptom onset. The invention also relates to a method for prognosing ACS in a subject, the method comprising measuring plasma MIF concentration in a sample from the subject, diagnosing ACS when the subject plasma MIF concentration is greater than a reference plasma MIF concentration, and prognosing the magnitude of ACS from the subject plasma MIF concentration. Also provided is a method of treating ACS in a subject, a device, a kit, and a cardiac biomarker related to the methods of diagnosing and prognosing ACS.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: June 14, 2022
    Assignees: ALFRED HEALTH, BAKER IDI HEART AND DIABETES INSTITUT HOLDINGS LTD.
    Inventor: Anthony Dart
  • Patent number: 11351548
    Abstract: A sensor system includes an assay chamber configured to receive a fluid sample. Dispense chemistry disposed within the assay chamber. A first electrode structure includes at least one conductive element and a second electrode structure proximate to the first electrode structure is configured to transmit an electrical signal through the fluid sample. The first electrode structure is configured to receive the electrical signal transmitted through the fluid sample and responsively generate a sense signal. The sense signal being indicative of an interaction of the fluid sample with the dispense chemistry. A controller is electrically coupled to the first electrode structure and configured to identify at least one analyte in the fluid sample based on at least the sense signal generated by the first electrode structure. The first electrode structure is embedded within a base substrate and the second electrode structure is embedded within a microfluidic cap that is coupled to the base substrate.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: June 7, 2022
    Assignee: MAXIM INTEGRATED PRODUCTS, INC.
    Inventors: Joy T. Jones, Ronald B. Koo, Paul G. Schroeder, Albert Song, Sudarsan Uppili, Xiaoming Yan, Qi Luo, Sean Cahill, Henry Grage
  • Patent number: 11325072
    Abstract: An object trapping device enables efficiently trapping a plurality of objects in a specific combination. Each of a first electrode pair (13), a second electrode pair (14), and a third electrode pair (15) in an electrode pair group (3) is applied with an individual AC voltage and traps an object by dielectrophoresis generated in accordance with the AC voltage that is applied.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 10, 2022
    Assignees: SHARP KABUSHIKI KAISHA, The University of Tokyo
    Inventors: Kunihiko Iizuka, Takeshi Mitsunaka, Yoshihisa Fujimoto, Teruo Fujii, Soo-Hyeon Kim
  • Patent number: 11328177
    Abstract: Systems and methods include processors for receiving training data for a user activity; receiving bias criteria; determining a set of model parameters for a machine learning model including: (1) applying the machine learning model to the training data; (2) generating model prediction errors; (3) generating a data selection vector to identify non-outlier target variables based on the model prediction errors; (4) utilizing the data selection vector to generate a non-outlier data set; (5) determining updated model parameters based on the non-outlier data set; and (6) repeating steps (1)-(5) until a censoring performance termination criterion is satisfied; training classifier model parameters for an outlier classifier machine learning model; applying the outlier classifier machine learning model to activity-related data to determine non-outlier activity-related data; and applying the machine learning model to the non-outlier activity-related data to predict future activity-related attributes for the user activity
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: May 10, 2022
    Assignee: HARTFORD STEAM BOILER INSPECTION AND INSURANCE COMPANY
    Inventor: Richard B. Jones
  • Patent number: 11313828
    Abstract: The biosensor includes a substrate, an electrode pattern positioned on the substrate, a passivation layer which is formed with a plurality of holes spaced apart from each other, and a bead positioned at one or more holes among the plurality of holes, and to which an antibody is attached, the electrode pattern includes a first electrode pattern part and a second electrode pattern part spaced apart from the first electrode pattern part, which has a same height as a height of the first electrode pattern part, and forms an electric field with the first electrode pattern part.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: April 26, 2022
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Ji Yoon Kang, Kyeong-Sik Shin, Jae-hoon Ji, Kyoseon Hwang, Tae Song Kim
  • Patent number: 11262305
    Abstract: A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: March 1, 2022
    Assignee: Sony Corporation
    Inventors: Yasunobu Kato, Yoshitsugu Sakai
  • Patent number: 11255756
    Abstract: A testing vessel 1 includes a flexible vessel body 10 having a bottom and a hollow shape; and a partition 11 axially extending in the vessel body 10 and dividing an analyte extract containable space 50 in the vessel body 10 into two or more compartments. The testing vessel 1 enables two or more items to be readily tested with two or more test pieces.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: February 22, 2022
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Kazunori Saito, Hiroyuki Oono, Kimiyoshi Nishitani, Motoki Morita, Shinji Matsuura, Hiroshi Yashiro
  • Patent number: 11255851
    Abstract: A system and method for evaluation of an interaction between an analyte in a fluid sample and a ligand immobilized on a sensor surface of a biosensor is provided. In one example, the system includes a plurality of needles, each being arranged to inject a fluid sample to one of sensor surfaces or detection spots. A plurality of fluid samples, each containing known concentrations of analyte, is provided. The plurality of fluid samples may be divided into at least two groups, each group having a number of fluid samples corresponding to the number of needles. The system and method is configured to perform the injections without intermediate regeneration or renewal of the immobilized ligand. Software for performing the steps of the method and a computer readable medium for storing the software are also provided.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: February 22, 2022
    Assignee: CYTIVA SWEDEN AB
    Inventor: Olof Karlsson
  • Patent number: 11253794
    Abstract: A method of preparing a universal blood product comprising obtaining a blood product; contacting the blood product with (i) hydroxyapatite; (ii) a carbonaceous material comprising at least a mixture of a first carbon particle having macroporous size ? and a second carbon particle having macroporous size ?; and (iii) at least one support matrix chemically associated with an antigenic determinant. to form a cleansed product; and recovering the cleansed product. A method of preparing a universal blood product comprising obtaining a blood product; contacting the blood product with (i) hydroxyapatite; (ii) a carbonaceous material comprising at least a mixture of a first carbon particle having macroporous size ? and a second carbon particle having macroporous size ?; and (iii) at least one support matrix chemically associated with an antigenic determinant. to form a cleansed product; wherein at least one of the hydroxyapatite, carbonaceous material and support matrix is functionalized.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: February 22, 2022
    Assignee: Proprietary Technology Assets, LLC
    Inventors: Carol A. Rae, Jan S. Simoni, John F. Moeller
  • Patent number: 11255808
    Abstract: Disclosed are a chemi-capacitive sensor using a nanomaterial and a method of manufacturing the same. The chemi-capacitive sensor includes a lower electrode including a conductor, an insulation part formed on the lower electrode and including an insulator, an upper electrode disposed on the insulation part and including a first electrode and a second electrode spaced apart from the first electrode, and a detection part disposed on the first electrode, the second electrode, and the insulation part between the first electrode and the second electrode and including at least one selected from the group consisting of a carbon nanomaterial and a metal-oxide-coated carbon nanomaterial. The chemi-capacitive sensor of the present invention is effective at selectively analyzing gas analytes.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: February 22, 2022
    Assignee: GACHON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
    Inventors: Jae-Hong Lim, Young Soo Yoon
  • Patent number: 11243785
    Abstract: A systems for optimizing a user interface includes a host service/device coupled to two databases. One database stores historical information of user interaction(s) with the interface and the another stores predefined query strings that when submitted to the first database obtain statistically testable datasets. As a result of this construction, a user of the optimization system is able to submit a request to the host service/device that includes (1) a selected user interface variation and (2) a selected user interaction goal. In response, the optimization system accesses the second database to retrieve a set of queries related to the variation and a set of queries related to the goal. Thereafter, the query sets can be submitted to the first database to obtain two testable datasets (e.g., a control set and a variant set) for automatic statistical analysis.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: February 8, 2022
    Assignees: ATLASSIAN PTY LTD., ATLASSIAN INC.
    Inventors: Fredrick Galoso, Nathan Selvidge, Ryan Sorensen
  • Patent number: 11199498
    Abstract: A portable spectrometer system is disclosed for more reliable and convenient on-site drug testing. More particularly, but not by way of limitation, the presently disclosed and/or claimed inventive concept(s) relates to a portable spectrometer system having a test strip having a fluorescent indicator, a fluorimeter, and a mobile computing device capable of determining the identity of an unknown substance in the sample.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: December 14, 2021
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Richard George Blair
  • Patent number: 11175509
    Abstract: The description relate to devices, such as augmented reality and/or virtual reality devices that employ optical waveguides. On example includes a first optical waveguide configured to receive light at an incidence angle and a second optical waveguide positioned in a non-parallel relation to the first optical waveguide. The second optical waveguide can be configured to receive the light through the first optical waveguide at a first location at the incidence angle, transmit the light within the second optical waveguide, and output the light from a second location back toward the first optical waveguide at the incidence angle.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: November 16, 2021
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Simo Kaarlo Tammela, Ari Juhani Tervonen, Heikki Juhana Hyvarinen, Lasse Pekka Karvonen, Andreas Langner, Pietari Tuomisto
  • Patent number: 11149301
    Abstract: The present disclosure relates to processes for derivatizing a surface of a substrate with a covalently bonded thin film of poly(methylsilsesquioxane)-bonded polymers as a platform for the synthesis of a biomolecule array. These processes can also be used to prepare a surface of a substrate for an in situ solid-phase synthesis of biomolecule array.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: October 19, 2021
    Assignee: CENTRILLION TECHNOLOGY HOLDINGS CORPORATION
    Inventor: Glenn McGall
  • Patent number: 11130985
    Abstract: In order to reduce the cost of producing a spot array substrate and reduce the cost of nucleic acid polymer analysis, a spot array substrate is used which is produced by preparing a resin substrate 402 having a surface on which an uneven pattern is formed and a plurality of bead sitting positions set in a two-dimensional array within the uneven pattern, and loading surface-modified beads onto the bead sitting positions of the resin substrate.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: September 28, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Naoshi Itabashi, Sonoko Migitaka, Masatoshi Narahara, Tomohiro Shoji, Yukio Ono
  • Patent number: 11124609
    Abstract: Polymer compositions for coating of metal surfaces including moieties that interact with a metal atom in the metal surface and optionally containing antifoulant moieties. These polymer compositions provide lubricious coatings for medical devices, anticorrosion coatings for metal components, and antifoulant coatings for marine components such as propellers. The polymer composition is synthesized in a safe manner in which the synthesis components are added to a synthesis vat and there is no need for filtration or removal of waste materials in any step including the consumer use. As such this invention provides an environmentally sound approach to composition synthesis, formulation development, and consumer use.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: September 21, 2021
    Assignee: Seabourne Solutions, LLC
    Inventor: John A. Lawton
  • Patent number: 11117131
    Abstract: Embodiments of the invention are directed to a method of separating and encapsulating an analyte on a microfluidic device in order to extract the analyte. A microfluidic device is provided having a main microchannel and a set of one or more auxiliary microchannels, each branching to the main microchannel at respective junctions therewith. A mixture is introduced as a single phase in the main microchannel in order to electrokinetically separate an analyte from the introduced mixture, and in order to confine the separated analyte in a microchannel portion of the main microchannel. The microchannel portion adjoins one of the junctions. One or more encapsulating volumes of an encapsulating phase are injected in the main microchannel via one or more of the auxiliary microchannels. The encapsulating phase is immiscible with said single phase. The encapsulated analyte is extracted from the main microchannel via one or more of the auxiliary microchannels.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: September 14, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, Technion Research and Development Foundation Ltd.
    Inventors: Govind Kaigala, Federico Paratore, Onur Gökçe, Moran Bercovici, Xander Van Kooten
  • Patent number: 11104708
    Abstract: The present invention relates to a polypeptide comprising a silk polypeptide and an antigen. Further, the present invention relates to an article comprising the polypeptide. Furthermore, the present invention relates to a pharmaceutical composition comprising the article. In addition, the present invention relates to the article or pharmaceutical composition for use as a pharmaceutical, for inducing an immune response and/or for use in a prophylactic and/or therapeutic treatment of a disease.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: August 31, 2021
    Assignees: Amsilk GmbH, Ludwig-Maximilians-Universitat Munchen, Universitat Bayreuth
    Inventors: Lin Romer, Ute Slotta, Julia Engert, Gerhard Winter, Matthias Lucke, Thomas Scheibel
  • Patent number: 11099110
    Abstract: A method of in-situ TEM nanoindentation for a damaged layer of silicon is disclosed. Wet etching and ion beam lithography are used for preparing a silicon wedge sample. An etched silicon wedge is thinned and trimmed by a focused ion beam; thinning uses ion beam of 30 kV: 50-80 nA, and trimming uses ion beam of 5 kV: 1-6 pA; and the top width of the silicon wedge is 80-100 nm. The sample is fixed on a sample holder of an in-situ TEM nanomechanical system by using a conductive silver adhesive. The sample is indented with a tip in the TEM, so that the thickness of the damaged layer of the sample is 2-200 nm; and an in-situ nanoindentation experiment is conducted on the damaged layer of the sample in the TEM.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: August 24, 2021
    Assignee: DALIAN UNIVERSITY OF TECHNOLOGY
    Inventors: Zhenyu Zhang, Junfeng Cui, Dongdong Liu
  • Patent number: 11077165
    Abstract: The invention provides (1) methods for modulating gene expression in senescent mammals by administering antioxidant-comprising compositions to the mammals and (2) antioxidant-comprising compositions that modulate gene expression and/or reduce the oxidative stress of such mammals.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: August 3, 2021
    Assignee: Hills Pet Nutrition, Inc.
    Inventors: Steven Curtis Zicker, Inke Paetau-Robinson, Karen Joy Wedekind
  • Patent number: 11066689
    Abstract: Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components. The platform may be configured for simultaneous multiplexed detection of a plurality biological components such that a large number of discrete samples may be individually sequestered and evaluated to detect or identify constituents from the samples in a highly parallelized and scalable manner.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: July 20, 2021
    Assignee: IsoPlexis Corporation
    Inventors: Patrick Paczkowski, Sean MacKay, Sean McCusker
  • Patent number: 11062891
    Abstract: The disclosure relates to a method which is suitable for the quality control and signal correction of mass spectrometry data of biological tissue samples and is based on the analysis of the chemical background signal observed in a spectrum. It exploits the fact that the chemical background signal contains components from a plurality of polymer molecules, whose chemical structure has strong regularities. These regularities mean that the observed masses are subject to certain statistical distributions, which are each characteristic of the class of molecule. By analyzing these statistical properties, it is possible to detect and correct any mass shifts which may be present.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: July 13, 2021
    Inventor: Tobias Boskamp
  • Patent number: 11035823
    Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. A plurality of smaller flow cells is employed, each with a relatively small area to be imaged, in order to provide greater flexibility and efficiency.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: June 15, 2021
    Assignee: Qiagen Sciences, LLC
    Inventors: Steven Gordon, Thomas Hagerott, Edmund Golaski, Jerzy Olejnik
  • Patent number: 11022578
    Abstract: A lateral flow assay device comprising a conjugate pad for receiving a quantity of fluid; and a membrane comprising a test line for determining whether the fluid comprises a target analyte. In a first state of the lateral flow assay device, the lateral flow assay device is configured with a removable gap between the conjugate pad and the membrane which is substantially filled with air and prevents the fluid from flowing from the conjugate pad into the membrane. In a second state of the lateral flow assay device, the removable gap is removed from between the conjugate pad and the membrane causing the conjugate pad to come in contact with the membrane, allowing the fluid to flow from the conjugate pad into the membrane and the test line by capillary action.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: June 1, 2021
    Assignee: 2Pi-Sigma Corp.
    Inventor: Mehdi Hatamian
  • Patent number: 11016087
    Abstract: Provided is an implement for inspection capable of measuring the concentration of a test substance with high accuracy. The implement for inspection according to the present invention is an implement for inspection used for measuring the concentration of a test substance that includes a compound for reacting with a test substance to form a granular substance or a compound which is for being bound to the test substance and is a granular substance, and a wall portion having a periodic structure on its surface.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: May 25, 2021
    Assignees: SEKISUI CHEMICAL CO., LTD., UNIVERSITY PUBLIC CORPORATION OSAKA
    Inventors: Yoshinori Akagi, Nobuhiko Inui, Kazuhiko Imamura, Takamasa Kouno, Shigeru Nomura, Tatsuro Endo
  • Patent number: 11009611
    Abstract: A radiation detection system may include a radiation source, and a surface plasmon resonance (SPR) radiation detector. The SPR radiation detector may include a structure, a surface plasmon support material on portions of the structure and configured to receive radiation from the radiation source that initiates a surface plasmon at an interface between the structure and the surface plasmon support material, and a probing device coupled to the structure and configured to detect the surface plasmon.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: May 18, 2021
    Assignee: EAGLE TECHNOLOGY, LLC
    Inventors: Susanne M. Lee, Madison A. Young, Erin K. Sharma
  • Patent number: 11002682
    Abstract: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port and a cartridge for input to the cartridge receiving port. An optical detection system in the housing is capable of providing an illuminated electric field useful for Raman spectroscopy. The cartridge may have a sample well. The sample well is loaded with a mixture of water containing the analyte, Raman-scattering nanoparticles and a calibration solution. The calibration solution contains an analogue of the analyte differing in its Raman response, for example an isotope of the analyte. Optionally, a chemical compound capable of increasing interaction between the analyte and the nanoparticles may be added.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: May 11, 2021
    Assignee: ONDAVIA, INC.
    Inventor: Mark Charles Peterman
  • Patent number: 11001887
    Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: May 11, 2021
    Assignee: QIAGEN SCIENCES, LLC
    Inventors: Steven Gordon, Jerzy Olejnik
  • Patent number: 11002671
    Abstract: A method of detecting a substance includes, for each position of a plurality of positions in a field of view of an environment: emitting from a light source a light beam including a predetermined wavelength that is absorbable by a constituent of the substance, controlling at least one mirror to direct the emitted light beam to the position in the field of view, detecting by a detector light resulting from the emitted light beam, and determining whether the constituent of the substance is present at the position in the field of view based on characteristics of the detected light; generating a detection map indicating a presence or an absence of the substance at the plurality of positions in the field of view of the environment; capturing, by an image capture device, an image of the environment; and identifying a portion of the captured image having the substance based on the detection map.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: May 11, 2021
    Assignee: SOTER TECHNOLOGIES, LLC
    Inventor: Cary Chu
  • Patent number: 10993705
    Abstract: The invention relates to a combined two-compartment device for diagnosing body liquids, which comprises: (a) an upper compartment for collecting and storing the body liquid; (b) a lower diagnostic compartment for diagnosing the body liquid at a diagnostic stage, said diagnostic compartment comprises a diagnostic strip; (c) an opening at the bottom wall between said upper compartment and said lower compartment, wherein said opening is kept blocked by a suitable valve until just before said diagnostic stage; and (d) a mechanism for releasing said blockage of said opening, thereby to allow flow of the body liquid to said lower compartment, and thereby to come into contact with said diagnostic strip and to affect the diagnostic strip accordingly.
    Type: Grant
    Filed: November 6, 2016
    Date of Patent: May 4, 2021
    Assignee: NOVAMED LTD.
    Inventors: Emil Katz, Gadi Porath
  • Patent number: 10969385
    Abstract: The present invention provides an analyte detection system for detecting target analytes in a sample. In particular, the invention provides a detection system in a rotor or disc format that utilizes a centrifugal force to move the sample through the detection system. Methods of using the rotor detection system to detect analytes in samples, particularly biological samples, and kits comprising the rotor detection system are also disclosed.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: April 6, 2021
    Assignee: ZOETIS SERVICES LLC
    Inventors: Rajesh K. Mehra, Kenneth P. Aron
  • Patent number: 10969324
    Abstract: An acoustic separation device for reagent manipulation a standing acoustic including a wave generating device and pairs of perforated pseudo walls comprising a longitudinal standing bulk acoustic wave (LSBAW) channel. The LSBAW channel provides local pressure field amplification to overcome drag forces arising from reagent flow. Further, method for manipulating a reagent under continuous flow conditions microcarrier particles locally confined in an acoustic separation device comprising an inlet and an outlet, a fluid routing layer coupled to a channel, a plurality of loading wells configured to hold a plurality of substances required for a desired synthesis, and a controller configured to distribute the plurality of substances held by the loading wells in a desired sequence. The device for antibody manipulation further comprises an ultrasound actuator, and a channel wherein the channel is separated from the ultrasound actuator.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: April 6, 2021
    Assignee: Washington University
    Inventors: Mikhail Berezin, John Mark Meacham, Michael Binkley