Involving An Insoluble Carrier For Immobilizing Immunochemicals Patents (Class 436/518)
  • Patent number: 11325072
    Abstract: An object trapping device enables efficiently trapping a plurality of objects in a specific combination. Each of a first electrode pair (13), a second electrode pair (14), and a third electrode pair (15) in an electrode pair group (3) is applied with an individual AC voltage and traps an object by dielectrophoresis generated in accordance with the AC voltage that is applied.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 10, 2022
    Assignees: SHARP KABUSHIKI KAISHA, The University of Tokyo
    Inventors: Kunihiko Iizuka, Takeshi Mitsunaka, Yoshihisa Fujimoto, Teruo Fujii, Soo-Hyeon Kim
  • Patent number: 11328177
    Abstract: Systems and methods include processors for receiving training data for a user activity; receiving bias criteria; determining a set of model parameters for a machine learning model including: (1) applying the machine learning model to the training data; (2) generating model prediction errors; (3) generating a data selection vector to identify non-outlier target variables based on the model prediction errors; (4) utilizing the data selection vector to generate a non-outlier data set; (5) determining updated model parameters based on the non-outlier data set; and (6) repeating steps (1)-(5) until a censoring performance termination criterion is satisfied; training classifier model parameters for an outlier classifier machine learning model; applying the outlier classifier machine learning model to activity-related data to determine non-outlier activity-related data; and applying the machine learning model to the non-outlier activity-related data to predict future activity-related attributes for the user activity
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: May 10, 2022
    Assignee: HARTFORD STEAM BOILER INSPECTION AND INSURANCE COMPANY
    Inventor: Richard B. Jones
  • Patent number: 11313828
    Abstract: The biosensor includes a substrate, an electrode pattern positioned on the substrate, a passivation layer which is formed with a plurality of holes spaced apart from each other, and a bead positioned at one or more holes among the plurality of holes, and to which an antibody is attached, the electrode pattern includes a first electrode pattern part and a second electrode pattern part spaced apart from the first electrode pattern part, which has a same height as a height of the first electrode pattern part, and forms an electric field with the first electrode pattern part.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: April 26, 2022
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Ji Yoon Kang, Kyeong-Sik Shin, Jae-hoon Ji, Kyoseon Hwang, Tae Song Kim
  • Patent number: 11262305
    Abstract: A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: March 1, 2022
    Assignee: Sony Corporation
    Inventors: Yasunobu Kato, Yoshitsugu Sakai
  • Patent number: 11255808
    Abstract: Disclosed are a chemi-capacitive sensor using a nanomaterial and a method of manufacturing the same. The chemi-capacitive sensor includes a lower electrode including a conductor, an insulation part formed on the lower electrode and including an insulator, an upper electrode disposed on the insulation part and including a first electrode and a second electrode spaced apart from the first electrode, and a detection part disposed on the first electrode, the second electrode, and the insulation part between the first electrode and the second electrode and including at least one selected from the group consisting of a carbon nanomaterial and a metal-oxide-coated carbon nanomaterial. The chemi-capacitive sensor of the present invention is effective at selectively analyzing gas analytes.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: February 22, 2022
    Assignee: GACHON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
    Inventors: Jae-Hong Lim, Young Soo Yoon
  • Patent number: 11255851
    Abstract: A system and method for evaluation of an interaction between an analyte in a fluid sample and a ligand immobilized on a sensor surface of a biosensor is provided. In one example, the system includes a plurality of needles, each being arranged to inject a fluid sample to one of sensor surfaces or detection spots. A plurality of fluid samples, each containing known concentrations of analyte, is provided. The plurality of fluid samples may be divided into at least two groups, each group having a number of fluid samples corresponding to the number of needles. The system and method is configured to perform the injections without intermediate regeneration or renewal of the immobilized ligand. Software for performing the steps of the method and a computer readable medium for storing the software are also provided.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: February 22, 2022
    Assignee: CYTIVA SWEDEN AB
    Inventor: Olof Karlsson
  • Patent number: 11253794
    Abstract: A method of preparing a universal blood product comprising obtaining a blood product; contacting the blood product with (i) hydroxyapatite; (ii) a carbonaceous material comprising at least a mixture of a first carbon particle having macroporous size ? and a second carbon particle having macroporous size ?; and (iii) at least one support matrix chemically associated with an antigenic determinant. to form a cleansed product; and recovering the cleansed product. A method of preparing a universal blood product comprising obtaining a blood product; contacting the blood product with (i) hydroxyapatite; (ii) a carbonaceous material comprising at least a mixture of a first carbon particle having macroporous size ? and a second carbon particle having macroporous size ?; and (iii) at least one support matrix chemically associated with an antigenic determinant. to form a cleansed product; wherein at least one of the hydroxyapatite, carbonaceous material and support matrix is functionalized.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: February 22, 2022
    Assignee: Proprietary Technology Assets, LLC
    Inventors: Carol A. Rae, Jan S. Simoni, John F. Moeller
  • Patent number: 11255756
    Abstract: A testing vessel 1 includes a flexible vessel body 10 having a bottom and a hollow shape; and a partition 11 axially extending in the vessel body 10 and dividing an analyte extract containable space 50 in the vessel body 10 into two or more compartments. The testing vessel 1 enables two or more items to be readily tested with two or more test pieces.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: February 22, 2022
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Kazunori Saito, Hiroyuki Oono, Kimiyoshi Nishitani, Motoki Morita, Shinji Matsuura, Hiroshi Yashiro
  • Patent number: 11243785
    Abstract: A systems for optimizing a user interface includes a host service/device coupled to two databases. One database stores historical information of user interaction(s) with the interface and the another stores predefined query strings that when submitted to the first database obtain statistically testable datasets. As a result of this construction, a user of the optimization system is able to submit a request to the host service/device that includes (1) a selected user interface variation and (2) a selected user interaction goal. In response, the optimization system accesses the second database to retrieve a set of queries related to the variation and a set of queries related to the goal. Thereafter, the query sets can be submitted to the first database to obtain two testable datasets (e.g., a control set and a variant set) for automatic statistical analysis.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: February 8, 2022
    Assignees: ATLASSIAN PTY LTD., ATLASSIAN INC.
    Inventors: Fredrick Galoso, Nathan Selvidge, Ryan Sorensen
  • Patent number: 11199498
    Abstract: A portable spectrometer system is disclosed for more reliable and convenient on-site drug testing. More particularly, but not by way of limitation, the presently disclosed and/or claimed inventive concept(s) relates to a portable spectrometer system having a test strip having a fluorescent indicator, a fluorimeter, and a mobile computing device capable of determining the identity of an unknown substance in the sample.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: December 14, 2021
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Richard George Blair
  • Patent number: 11175509
    Abstract: The description relate to devices, such as augmented reality and/or virtual reality devices that employ optical waveguides. On example includes a first optical waveguide configured to receive light at an incidence angle and a second optical waveguide positioned in a non-parallel relation to the first optical waveguide. The second optical waveguide can be configured to receive the light through the first optical waveguide at a first location at the incidence angle, transmit the light within the second optical waveguide, and output the light from a second location back toward the first optical waveguide at the incidence angle.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: November 16, 2021
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Simo Kaarlo Tammela, Ari Juhani Tervonen, Heikki Juhana Hyvarinen, Lasse Pekka Karvonen, Andreas Langner, Pietari Tuomisto
  • Patent number: 11149301
    Abstract: The present disclosure relates to processes for derivatizing a surface of a substrate with a covalently bonded thin film of poly(methylsilsesquioxane)-bonded polymers as a platform for the synthesis of a biomolecule array. These processes can also be used to prepare a surface of a substrate for an in situ solid-phase synthesis of biomolecule array.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: October 19, 2021
    Assignee: CENTRILLION TECHNOLOGY HOLDINGS CORPORATION
    Inventor: Glenn McGall
  • Patent number: 11130985
    Abstract: In order to reduce the cost of producing a spot array substrate and reduce the cost of nucleic acid polymer analysis, a spot array substrate is used which is produced by preparing a resin substrate 402 having a surface on which an uneven pattern is formed and a plurality of bead sitting positions set in a two-dimensional array within the uneven pattern, and loading surface-modified beads onto the bead sitting positions of the resin substrate.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: September 28, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Naoshi Itabashi, Sonoko Migitaka, Masatoshi Narahara, Tomohiro Shoji, Yukio Ono
  • Patent number: 11124609
    Abstract: Polymer compositions for coating of metal surfaces including moieties that interact with a metal atom in the metal surface and optionally containing antifoulant moieties. These polymer compositions provide lubricious coatings for medical devices, anticorrosion coatings for metal components, and antifoulant coatings for marine components such as propellers. The polymer composition is synthesized in a safe manner in which the synthesis components are added to a synthesis vat and there is no need for filtration or removal of waste materials in any step including the consumer use. As such this invention provides an environmentally sound approach to composition synthesis, formulation development, and consumer use.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: September 21, 2021
    Assignee: Seabourne Solutions, LLC
    Inventor: John A. Lawton
  • Patent number: 11117131
    Abstract: Embodiments of the invention are directed to a method of separating and encapsulating an analyte on a microfluidic device in order to extract the analyte. A microfluidic device is provided having a main microchannel and a set of one or more auxiliary microchannels, each branching to the main microchannel at respective junctions therewith. A mixture is introduced as a single phase in the main microchannel in order to electrokinetically separate an analyte from the introduced mixture, and in order to confine the separated analyte in a microchannel portion of the main microchannel. The microchannel portion adjoins one of the junctions. One or more encapsulating volumes of an encapsulating phase are injected in the main microchannel via one or more of the auxiliary microchannels. The encapsulating phase is immiscible with said single phase. The encapsulated analyte is extracted from the main microchannel via one or more of the auxiliary microchannels.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: September 14, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, Technion Research and Development Foundation Ltd.
    Inventors: Govind Kaigala, Federico Paratore, Onur Gökçe, Moran Bercovici, Xander Van Kooten
  • Patent number: 11104708
    Abstract: The present invention relates to a polypeptide comprising a silk polypeptide and an antigen. Further, the present invention relates to an article comprising the polypeptide. Furthermore, the present invention relates to a pharmaceutical composition comprising the article. In addition, the present invention relates to the article or pharmaceutical composition for use as a pharmaceutical, for inducing an immune response and/or for use in a prophylactic and/or therapeutic treatment of a disease.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: August 31, 2021
    Assignees: Amsilk GmbH, Ludwig-Maximilians-Universitat Munchen, Universitat Bayreuth
    Inventors: Lin Romer, Ute Slotta, Julia Engert, Gerhard Winter, Matthias Lucke, Thomas Scheibel
  • Patent number: 11099110
    Abstract: A method of in-situ TEM nanoindentation for a damaged layer of silicon is disclosed. Wet etching and ion beam lithography are used for preparing a silicon wedge sample. An etched silicon wedge is thinned and trimmed by a focused ion beam; thinning uses ion beam of 30 kV: 50-80 nA, and trimming uses ion beam of 5 kV: 1-6 pA; and the top width of the silicon wedge is 80-100 nm. The sample is fixed on a sample holder of an in-situ TEM nanomechanical system by using a conductive silver adhesive. The sample is indented with a tip in the TEM, so that the thickness of the damaged layer of the sample is 2-200 nm; and an in-situ nanoindentation experiment is conducted on the damaged layer of the sample in the TEM.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: August 24, 2021
    Assignee: DALIAN UNIVERSITY OF TECHNOLOGY
    Inventors: Zhenyu Zhang, Junfeng Cui, Dongdong Liu
  • Patent number: 11077165
    Abstract: The invention provides (1) methods for modulating gene expression in senescent mammals by administering antioxidant-comprising compositions to the mammals and (2) antioxidant-comprising compositions that modulate gene expression and/or reduce the oxidative stress of such mammals.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: August 3, 2021
    Assignee: Hills Pet Nutrition, Inc.
    Inventors: Steven Curtis Zicker, Inke Paetau-Robinson, Karen Joy Wedekind
  • Patent number: 11066689
    Abstract: Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components. The platform may be configured for simultaneous multiplexed detection of a plurality biological components such that a large number of discrete samples may be individually sequestered and evaluated to detect or identify constituents from the samples in a highly parallelized and scalable manner.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: July 20, 2021
    Assignee: IsoPlexis Corporation
    Inventors: Patrick Paczkowski, Sean MacKay, Sean McCusker
  • Patent number: 11062891
    Abstract: The disclosure relates to a method which is suitable for the quality control and signal correction of mass spectrometry data of biological tissue samples and is based on the analysis of the chemical background signal observed in a spectrum. It exploits the fact that the chemical background signal contains components from a plurality of polymer molecules, whose chemical structure has strong regularities. These regularities mean that the observed masses are subject to certain statistical distributions, which are each characteristic of the class of molecule. By analyzing these statistical properties, it is possible to detect and correct any mass shifts which may be present.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: July 13, 2021
    Inventor: Tobias Boskamp
  • Patent number: 11035823
    Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. A plurality of smaller flow cells is employed, each with a relatively small area to be imaged, in order to provide greater flexibility and efficiency.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: June 15, 2021
    Assignee: Qiagen Sciences, LLC
    Inventors: Steven Gordon, Thomas Hagerott, Edmund Golaski, Jerzy Olejnik
  • Patent number: 11022578
    Abstract: A lateral flow assay device comprising a conjugate pad for receiving a quantity of fluid; and a membrane comprising a test line for determining whether the fluid comprises a target analyte. In a first state of the lateral flow assay device, the lateral flow assay device is configured with a removable gap between the conjugate pad and the membrane which is substantially filled with air and prevents the fluid from flowing from the conjugate pad into the membrane. In a second state of the lateral flow assay device, the removable gap is removed from between the conjugate pad and the membrane causing the conjugate pad to come in contact with the membrane, allowing the fluid to flow from the conjugate pad into the membrane and the test line by capillary action.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: June 1, 2021
    Assignee: 2Pi-Sigma Corp.
    Inventor: Mehdi Hatamian
  • Patent number: 11016087
    Abstract: Provided is an implement for inspection capable of measuring the concentration of a test substance with high accuracy. The implement for inspection according to the present invention is an implement for inspection used for measuring the concentration of a test substance that includes a compound for reacting with a test substance to form a granular substance or a compound which is for being bound to the test substance and is a granular substance, and a wall portion having a periodic structure on its surface.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: May 25, 2021
    Assignees: SEKISUI CHEMICAL CO., LTD., UNIVERSITY PUBLIC CORPORATION OSAKA
    Inventors: Yoshinori Akagi, Nobuhiko Inui, Kazuhiko Imamura, Takamasa Kouno, Shigeru Nomura, Tatsuro Endo
  • Patent number: 11009611
    Abstract: A radiation detection system may include a radiation source, and a surface plasmon resonance (SPR) radiation detector. The SPR radiation detector may include a structure, a surface plasmon support material on portions of the structure and configured to receive radiation from the radiation source that initiates a surface plasmon at an interface between the structure and the surface plasmon support material, and a probing device coupled to the structure and configured to detect the surface plasmon.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: May 18, 2021
    Assignee: EAGLE TECHNOLOGY, LLC
    Inventors: Susanne M. Lee, Madison A. Young, Erin K. Sharma
  • Patent number: 11002682
    Abstract: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port and a cartridge for input to the cartridge receiving port. An optical detection system in the housing is capable of providing an illuminated electric field useful for Raman spectroscopy. The cartridge may have a sample well. The sample well is loaded with a mixture of water containing the analyte, Raman-scattering nanoparticles and a calibration solution. The calibration solution contains an analogue of the analyte differing in its Raman response, for example an isotope of the analyte. Optionally, a chemical compound capable of increasing interaction between the analyte and the nanoparticles may be added.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: May 11, 2021
    Assignee: ONDAVIA, INC.
    Inventor: Mark Charles Peterman
  • Patent number: 11001887
    Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: May 11, 2021
    Assignee: QIAGEN SCIENCES, LLC
    Inventors: Steven Gordon, Jerzy Olejnik
  • Patent number: 11002671
    Abstract: A method of detecting a substance includes, for each position of a plurality of positions in a field of view of an environment: emitting from a light source a light beam including a predetermined wavelength that is absorbable by a constituent of the substance, controlling at least one mirror to direct the emitted light beam to the position in the field of view, detecting by a detector light resulting from the emitted light beam, and determining whether the constituent of the substance is present at the position in the field of view based on characteristics of the detected light; generating a detection map indicating a presence or an absence of the substance at the plurality of positions in the field of view of the environment; capturing, by an image capture device, an image of the environment; and identifying a portion of the captured image having the substance based on the detection map.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: May 11, 2021
    Assignee: SOTER TECHNOLOGIES, LLC
    Inventor: Cary Chu
  • Patent number: 10993705
    Abstract: The invention relates to a combined two-compartment device for diagnosing body liquids, which comprises: (a) an upper compartment for collecting and storing the body liquid; (b) a lower diagnostic compartment for diagnosing the body liquid at a diagnostic stage, said diagnostic compartment comprises a diagnostic strip; (c) an opening at the bottom wall between said upper compartment and said lower compartment, wherein said opening is kept blocked by a suitable valve until just before said diagnostic stage; and (d) a mechanism for releasing said blockage of said opening, thereby to allow flow of the body liquid to said lower compartment, and thereby to come into contact with said diagnostic strip and to affect the diagnostic strip accordingly.
    Type: Grant
    Filed: November 6, 2016
    Date of Patent: May 4, 2021
    Assignee: NOVAMED LTD.
    Inventors: Emil Katz, Gadi Porath
  • Patent number: 10969385
    Abstract: The present invention provides an analyte detection system for detecting target analytes in a sample. In particular, the invention provides a detection system in a rotor or disc format that utilizes a centrifugal force to move the sample through the detection system. Methods of using the rotor detection system to detect analytes in samples, particularly biological samples, and kits comprising the rotor detection system are also disclosed.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: April 6, 2021
    Assignee: ZOETIS SERVICES LLC
    Inventors: Rajesh K. Mehra, Kenneth P. Aron
  • Patent number: 10969324
    Abstract: An acoustic separation device for reagent manipulation a standing acoustic including a wave generating device and pairs of perforated pseudo walls comprising a longitudinal standing bulk acoustic wave (LSBAW) channel. The LSBAW channel provides local pressure field amplification to overcome drag forces arising from reagent flow. Further, method for manipulating a reagent under continuous flow conditions microcarrier particles locally confined in an acoustic separation device comprising an inlet and an outlet, a fluid routing layer coupled to a channel, a plurality of loading wells configured to hold a plurality of substances required for a desired synthesis, and a controller configured to distribute the plurality of substances held by the loading wells in a desired sequence. The device for antibody manipulation further comprises an ultrasound actuator, and a channel wherein the channel is separated from the ultrasound actuator.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: April 6, 2021
    Assignee: Washington University
    Inventors: Mikhail Berezin, John Mark Meacham, Michael Binkley
  • Patent number: 10961574
    Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: March 30, 2021
    Assignee: QIAGEN SCIENCES, LLC
    Inventors: Steven Gordon, Jerzy Olejnik
  • Patent number: 10962546
    Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: March 30, 2021
    Assignee: SIRIGEN II LIMITED
    Inventors: Brent S. Gaylord, Glenn P. Bartholomew, Russell A. Baldocchi, Janice W. Hong, William H. Huisman, Yongchao Liang, Trung Nguyen, Lan T. Tran, Jean M. Wheeler, Adrian Charles Vernon Palmer, Frank Peter Uckert
  • Patent number: 10956930
    Abstract: Dynamic Hierarchical Empirical Bayes techniques and systems are described that are implemented to control output of digital content. In one example, a system identifies splitting variables included in data. An amount of loss is then determined for each of the identified splitting variables by the system using a loss function. Based on the determined amounts of loss, the system selects at least one splitting variable from the plurality of splitting variables that are to be used to partition data in a respective node, e.g., a parent node to form a plurality of child nodes. The system, for instance, may select the splitting variable that minimizes the cost, i.e., has the lowest amount of cost. The selected splitting variable is then employed by the system to generate at least one hierarchical level of the hierarchical structure of the statistical model by partitioning data from the parent node into respective child nodes.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: March 23, 2021
    Assignee: Adobe Inc.
    Inventors: Yuan Yuan, Zhenyu Yan, Yiwen Sun, Xiaojing Dong, Chen Dong, Abhishek Pani
  • Patent number: 10948500
    Abstract: Methods and kits-of-parts for determining the quantity of HbA1c relative to the concentration of haemoglobin in a blood sample which includes less than 200 ?l of blood, the method including the steps of adding the fluorophore to the sample and measuring the fluorescence at one or more time points within the time interval, at which the change in fluorescence over time is >0, followed by measurements of haemoglobin by adding a haemoglobin-binding agent and measuring the change in transmission at approximately 570 nm and comparing the obtained results with an internal standard.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: March 16, 2021
    Assignee: W. Health L.P.
    Inventor: Peter Warthoe
  • Patent number: 10941319
    Abstract: Process for printing an adhesive pattern on a polymer brush extending at the surface of a support (1), forming a nanometric anti-fouling layer (2), the process comprising the following steps: —placing the layer (2) in contact with a first aqueous solution (4) containing a benzophenone, —then illuminating the layer with radiation (3) at a wavelength within the absorption spectrum of benzophenone, according to the pattern and according to a surface energy.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: March 9, 2021
    Assignees: ALVEOLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITÉ DE BORDEAUX
    Inventor: Vincent Studer
  • Patent number: 10914738
    Abstract: A subtractive immunoassay for detecting the presence or absence of first and second analytes in a sample includes in the following order the steps of: a) conjugating a first detector antibody to the first analyte to tag the first analyte with a first detector tag; b) conjugating a first capture antibody to the first analyte to capture the first analyte to completely deplete the first analyte from the sample; c) conjugating a second detector antibody to the second analyte in the depleted sample to tag the second analyte with a second detector tag; d) conjugating a second capture antibody to the second analyte to capture the second analyte from the sample; e) detecting presence or absence of the first and second detector tags at the site of the first and second capture antibody, respectively, and thereby detecting the presence or absence of the first and second analytes in the sample.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: February 9, 2021
    Inventors: Thomas Bruderer, Madhavi Muranjan
  • Patent number: 10864359
    Abstract: A medical delivery device includes a first compartment configured to hold at least a portion of an activator that activates one or more molecular nanomachines. The first compartment includes a first wall that includes a first ferrous material, where the first wall is configured to disintegrate in response to first electromagnetic radiation received by the first ferrous material such that the activator activates the one or more molecular nanomachines. The device includes a second compartment configured to hold the one or more molecular nanomachines, wherein the second compartment includes a second wall that includes a second ferrous material, and wherein the second wall is configured to disintegrate and release the one or more molecular nanomachines into a patient in response to second electromagnetic radiation received by the second ferrous material.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: December 15, 2020
    Inventor: Bernard Fryshman
  • Patent number: 10858429
    Abstract: The present invention relates to methods for preventing or treating head and neck spuamous cell cancer and bladder cancer using an immunotoxin comprising (a) a ligand that binds to a protein on the cancer cell attached to; (b) a toxin that is cytotoxic to the cancer cell. In a specific embodiment, the invention is directed to the prevention or treatment of head and neck squamous cell cancer or bladder cancer using Vb4-845, which is a recombinant immunotixin comprising a humanized, MOC31-derived, single-chain antibody fragment that is fused to a truncated form of Pseudomonas exotoxin A. Also encompassed by the invention are combination therapy methods, including the use of reduced dosages of chemotherapeutic agents, for the prevention or treatment of cancer. Also encompassed by the invention are formulations and methods for direct administration of the recombinant immunotoxin to the carcinoma, for the prevention or treatment of cancer.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: December 8, 2020
    Assignee: UNIVERSITY OF ZURICH
    Inventors: Uwe Zangemeister-Wittke, Claudio Di Paolo, Dominique Christine Tschudi, Nicholas Ronald Glover, Dimitri Peter Fitsialos
  • Patent number: 10830842
    Abstract: It is an object of the invention to provide for an improved method for device localization using magnetic resonance imaging (MRI) during MRI guided interventions.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: November 10, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Sascha Krueger
  • Patent number: 10828381
    Abstract: The presently-disclosed subject matter relates to an artificial RNA nanostructure and method of use thereof. In particular, the presently-disclosed subject matter relates to RNA nanoparticles and RNA dendrimers, and methods of disease diagnosis and treatments using the RNA nanostructure and RNA dendrimers.
    Type: Grant
    Filed: April 17, 2016
    Date of Patent: November 10, 2020
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Peixuan Guo, Hui Li, Wei Luo
  • Patent number: 10807087
    Abstract: The invention concerns a lateral flow device, system, kit and method for analyzing a fluid sample. The device comprises a support structure, a flow channel formed in the support structure, and an injection zone in fluidic connection with the flow channel for introducing the fluid sample into the flow channel. According to the invention the flow channel comprises at least two indicator zones at least one of which is capable of producing an optically detectable response signal when interacting with the fluid sample, and the indicator zones are arranged at least partly adjacent to each other on different sections of the flow channel. The invention allows for low-cost imaging devices, such as cameras of mobile phones to be used for making challenging lateral flow diagnostics on a variety of fields of technology.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: October 20, 2020
    Assignee: Teknologian tutkimuskeskus VTT Oy
    Inventors: Jukka-Tapani Mäkinen, Sanna Uusitalo, Marika Kurkinen
  • Patent number: 10745740
    Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: August 18, 2020
    Assignee: Qiagen Sciences, LLC
    Inventors: Steven Gordon, Phillip A Veatch
  • Patent number: 10739366
    Abstract: A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 11, 2020
    Assignee: The Johns Hopkins University
    Inventors: Tza-huei J. Wang, Tushar Dnyandeo Rane, Helena Claire Zec, Wen-Chy Chu
  • Patent number: 10739297
    Abstract: A lateral flow assay device comprising a conjugate pad for receiving a quantity of fluid; and a membrane comprising a test line for determining whether the fluid comprises a target analyte. In a first state of the lateral flow assay device, the lateral flow assay device is configured with a removable gap between the conjugate pad and the membrane which is substantially filled with air and prevents the fluid from flowing from the conjugate pad into the membrane. In a second state of the lateral flow assay device, the removable gap is removed from between the conjugate pad and the membrane causing the conjugate pad to come in contact with the membrane, allowing the fluid to flow from the conjugate pad into the membrane and the test line by capillary action.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: August 11, 2020
    Assignee: 2Pi-Sigma Corp.
    Inventor: Mehdi Hatamian
  • Patent number: 10725048
    Abstract: Disclosed is a method for detecting a test substance, including a first contact step of bringing the test substance, a capturing body 1 that has binding properties to the test substance and is fixed to a substrate, and a capturing body 2 that has binding properties to the test substance and contains a label into contact with each other in a liquid to arrange at least a part of the capturing body 2 on the substrate; after the first contact step, a first dissociation step of dissociating a part of substances containing the capturing body 2 from the substrate and releasing it into the liquid; after the first dissociation step, a second contact step of bringing the test substance, the capturing body 1 that has binding properties to the test substance and is fixed to a substrate, and the capturing body 2 that has binding properties to the test substance and contains a label into contact with each other in the liquid to arrange at least a part of the capturing body 2 on the substrate; after the second contact step,
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: July 28, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Kenji Akama, Hiroya Kirimura
  • Patent number: 10725031
    Abstract: Devices for detection of analytes in samples of various complexities are provided. The devices allow reflux of liquid into a sample-receiving member, providing for suitable analyte dilution and preventing leakage of cells or particulate material into the signal generation member. In one aspect, the devices are used to test analytes in biological samples such as blood, serum, plasma or other body fluids. In another aspect, the devices are used to test samples from tissues, such as organ tissues, tumor samples, or other body parts. In a further aspect, the devices are used to test microbial samples, food samples, or any other sample from which the analyte of interest can be captured into the reflux device.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: July 28, 2020
    Assignee: ConquerAb Inc.
    Inventor: Maria D. F. S. Barbosa
  • Patent number: 10722882
    Abstract: The disclosure provides compositions, kits and methods comprising an absorbent pad comprising a fibrous material and a liquid formulation comprising a luminescent substrate for identifying and quantifying biomolecule analytes.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: July 28, 2020
    Assignee: Pierce Biotechnology, Inc.
    Inventors: Surbhi Desai, Kari Severson
  • Patent number: 10716867
    Abstract: A composition includes a plurality of gold nanoparticles each having at least one surface. The gold nanoparticles have an average length of at least about 90 nm and an average width of at least about 25 nm.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: July 21, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Adam De La Zerda, Orly Liba, Elliott Sorelle, Bryan Knysh
  • Patent number: 10684277
    Abstract: A method for colorimetric detection of cholesterol in a sample is disclosed. The method includes adding beta-cyclodextrin and cholesterol to a phenolphthalein indicator solution in the presence of a phosphate buffer solution to create a solution medium and quantifying the cholesterol as a function of a complexed beta-cyclodextrin in the solution medium.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: June 16, 2020
    Assignee: COMSATS Institute of Information Technology
    Inventors: Akhtar Hayat, Muhammad Azhar Hayat Nawaz
  • Patent number: 10670615
    Abstract: A system for determining a concentration of hemoglobin A1C includes a first lateral flow test strip, the first lateral flow test strip providing for a percent of HbA1C concentration; a second lateral flow test strip, the second lateral flow test strip providing for the total amount of hemoglobin; an antibody-microparticle stripe on each of the first and second lateral flow test strips; a conjugate stripe on each of the first and second lateral flow test strips; and a sample treatment buffer. The sample treatment buffer is strongly denaturing, and antibodies in the antibody-microparticle strip are covalently bound to microparticles.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: June 2, 2020
    Assignee: Polymer Technology Systems, Inc.
    Inventors: Charles Z. Xie, Jane Kyung, Tu-Anh Nguyen, Annie V. Mendoza, Keith Moskowitz