Lanthanide Or Actinide Patents (Class 436/82)
-
Patent number: 7094608Abstract: The present invention relates to a method for measuring the content of Lanthanides dissolved in uranium oxide, wherein the Lanthanides content in the nuclear fuel pellet is measured using the thermo gravimetric analysis which measures the weight variation caused by the oxidation and heat treatment of the nuclear fuel pellet. This method provides an advantage in that the Lanthanide content can be measured using relatively simple equipments such as an electric furnace and a balance.Type: GrantFiled: November 27, 2002Date of Patent: August 22, 2006Assignees: Korea Atomic Energy Research Institute, Korea Hydro & Nuclear Power Co., Ltd.Inventors: Keon-Sik Kim, Jae-Ho Yang, Kun-Woo Song, Ki-Won Kang, Youn-Ho Jung
-
Patent number: 7067275Abstract: A bioanalytical method for determining catalases and peroxidases using europium ions.Type: GrantFiled: November 11, 2002Date of Patent: June 27, 2006Assignee: Active Motif Chromeon GmbHInventors: Otto S. Wolfbeis, Meng Wu, Zhihong Lin
-
Patent number: 6933153Abstract: This invention relates to a metal ion specific capacitance sensor with exceptional sensitivity and wide operating range. It is versatile because different kinds of recognition elements can be immobilized directly in a self-assembling monolayer substantially completely covering the surface of the measuring noble metal electrode. The electrode then becomes selective to those metal ions in the solution that show affinity to the recognition element on the surface. Compared to previously described electrochemical sensors, the sensor according to the present invention shows many orders of magnitude better sensitivity because of the unique measuring principle.Type: GrantFiled: September 15, 1998Date of Patent: August 23, 2005Assignees: Vlaamse Instelling Voor Technologish Onderzoek, School Biological Sciences at the University of BirminghamInventors: Bo Mattiasson, Elisabeth Csoregi, Ibolya Bontidean, Gillis Johansson, Christine Berggren, Nigel Brown, Jonathan Lloyd, Kenneth Jakeman, Jonathan Hobman, Jonathan Wilson, Daniel Van Der Leile, Philippe Corbisier
-
Patent number: 6897070Abstract: Sensors and methods of monitoring for the presence of gas phase materials by detecting the formation of films based on the gas phase material are disclosed. Advantageously, some gas phase materials preferentially deposit on specific surfaces. As a result, selective detection of those gas phase materials can be obtained by detecting films deposited on those detection surfaces. Examples of gas phase materials that may be detected include RuO4, IrO4 and RhO4.Type: GrantFiled: September 1, 1999Date of Patent: May 24, 2005Assignee: Micron Technology, Inc.Inventor: Guy T. Blalock
-
Patent number: 6875615Abstract: The present invention relates to sensors for the determination of organometallic compounds comprising the following elements: a) an inorganic, organic or polymeric support, insoluble in the sample to analyze b) an indicator which reversibly reacts with the organometallic compound and whose reaction product gives a characteristic absorption, reflection or emission band in the range 150-15000 nm and which is physically trapped, adsorbed, absorbed, dissolved or chemically linked in an electrostatic or covalent way to the support c) an optical sensor which measures the absorption, reflection or emission of the functionalized support at the characteristic wavelength and transforms it in the concentration of the organometallic present in the solution. Also described is the method for the determination of the concentration of organometallic compounds by the on line use of a sensor as above defined.Type: GrantFiled: April 17, 2002Date of Patent: April 5, 2005Assignee: Dynasol Elastomeros, S.A.Inventors: Luisa Maria Fraga Trillo, Valentin Ruiz Santa Quiteria, Guillermo Orellana Moraleda, Ana Maria Castro Franco
-
Patent number: 6821786Abstract: A self-diagnostic test, a self-diagnostic test apparatus, and method of manufacturing a self-diagnostic test for screening for elemental mineral imbalances in a patient utilizing an analysis of the reaction of mineral specific reagents to a sample from a patient are provided. In one embodiment, the invention is directed to a test for those elements that occur naturally in the body. In such an embodiment, the invention may test for those elements that comprise about 0.001% of the body weight or less (microtrace), those elements that comprise about 4% of the body weight or less (trace), those elements that comprise up to 96% of the body weight (mass), or any combination of the above.Type: GrantFiled: April 24, 2003Date of Patent: November 23, 2004Assignee: Future Data Inc.Inventor: Michael E. Rupp
-
Patent number: 6689613Abstract: A combinatorial method is provided for the preparation and screening of heterogeneous catalysts. The method comprises the steps of: (I) providing a library of elemental catalysts; (II) reacting the catalysts with a carbon source to form product directly on the catalyst; and (III) screening the products to evaluate the catalysts.Type: GrantFiled: March 28, 2000Date of Patent: February 10, 2004Assignee: General Electric CompanyInventors: Xiao-Dong Sun, Navjot Singh
-
Patent number: 6682934Abstract: A portable instrument for automatic collection and analysis of airborne lead concentrations in ambient air environments. Its improvements to the art of airborne lead detection and analysis permit the apparatus to analyze samples previously collected by personal monitors, for example, worn on the clothing of personnel working in contaminated sites. The apparatus also brings to the art of lead analysis a method of contaminant collection that ensures a greater capture efficiency of airborne contaminants, thereby increasing the accuracy of the instrument and its measurement capabilities while providing near real-time analysis and measurement in a portable self-contained battery-powered device. The apparatus also offers a remarkable improvement in the reduction of wastes incurred in the collection and analysis of airborne lead contaminants which is a novel method of concentrating the samples and recycling the analysis media used to concentrate and solubilize lead contaminants.Type: GrantFiled: October 1, 2001Date of Patent: January 27, 2004Assignee: The United States of America as represented by the Secretary of the NavyInventors: Clifford Jolly, Leslie A. Karr, Bryan Lee Harre, Barbara Marie Sugiyama, John Joseph Kornuc
-
Publication number: 20030170907Abstract: The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a &bgr;-dietone of formula I 1Type: ApplicationFiled: March 8, 2002Publication date: September 11, 2003Inventors: Ilkka Hemmila, Kaj Blomberg, Veli-Matti Mukkala, Harri Hakala
-
Patent number: 6607918Abstract: A fluorescent probe is applied to bind to a metal oxide on a substrate and the substrate is exposed to an ultraviolet light to identify the metal oxide. A chemical cleaning or stripping solution is selected by combinatorial high throughput screening (CHTS). In the method, an array of regions is defined on a substrate, a candidate cleaning/stripping solution is deposited onto the regions to effect cleaning/stripping of the regions; a fluorescent probe is applied to bind to a metal oxide on the substrate; the substrate is exposed to an ultraviolet light to identify the metal oxide and a product of the cleaning/stripping is evaluated according to the identified metal oxide. An activated metal substrate composition is provided that comprises a metal substrate with a contaminant metal oxide coating and a fluorescent activator bound to the substrate by reaction with the metal oxide coating.Type: GrantFiled: February 1, 2001Date of Patent: August 19, 2003Assignee: General Electric CompanyInventors: John Robert LaGraff, James Claude Carnahan, D Sangeeta, James Anthony Ruud
-
Publication number: 20030153091Abstract: An article for delivery of a chemical reactant includes a liquid or solvated chemical reactant pre-moistened into an applicator. A chemical reactant impervious package has a pouch adapted to enclose the applicator for storage. The chemical reactant delivery article is based on capillary action to wick the continuing supply of chemical reactant to the substrate contacting portion of the applicator and as such is operative independent of chemical reactant gravitational flow.Type: ApplicationFiled: February 11, 2002Publication date: August 14, 2003Inventors: Dean M. Willard, Mark W. Feist, Hans E. Haas, Marcia Snyder, Jonathan D. Zook
-
Publication number: 20030138958Abstract: Sensors and methods of monitoring for the presence of gas phase materials by detecting the formation of films based on the gas phase material are disclosed. Advantageously, some gas phase materials preferentially deposit on specific surfaces. As a result, selective detection of those gas phase materials can be obtained by detecting films deposited on those detection surfaces. Examples of gas phase materials that may be detected include RuO4, IrO4 and RhO4.Type: ApplicationFiled: September 1, 1999Publication date: July 24, 2003Inventor: GUY T. BLALOCK
-
Publication number: 20030027349Abstract: Disclosed is a method of performing assay to a fluorite sample, which includes a first step for dissolving a fluorite sample, containing Ca and F, by use of a solvent, a second step for removing Ca and F from an obtained solution, and a third step for assaying, through ICP-MS, the solution having Ca and F removed therefrom. Also disclosed is a method of producing a fluorite crystal and an exposure apparatus using such fluorite crystal, and a device manufacturing method using such exposure apparatus. The assaying method of the present invention ensures assay and evaluation of a fluorite sample, of sensitivity several times higher than conventional methods.Type: ApplicationFiled: July 3, 2002Publication date: February 6, 2003Inventor: Kenji Ookubo
-
Publication number: 20030003587Abstract: A device for measuring and detecting at least one narcotic, such as heroin and cocaine, in a fluid is provided. The device functions by selectively binding vapors of a narcotic or a narcotic present in a liquid, e.g., blood, to a luminescent molecularly imprinted polymer. The polymer possesses a securely bound luminescent lanthanide ion, such as Eu3+, in a coordination complex that has been templated with a narcotic.Type: ApplicationFiled: June 28, 2002Publication date: January 2, 2003Inventor: George M Murray
-
Patent number: 6455317Abstract: A system and method for controlling a microwave heated chemical process is disclosed. Time varying concentrations of some chemical substances within fumes in the microwave oven are monitored to detect concentration variations for which responses are known. Responses to the detected variations are initiated to control the chemical process without terminating the process. Examples of responses include varying microwave radiation energy, initiating safety systems, increased venting of the microwave oven, and so forth.Type: GrantFiled: March 6, 2000Date of Patent: September 24, 2002Assignee: Milestone s.r.L.Inventor: Werner Lautenschlager
-
Patent number: 6391647Abstract: The present invention refers to a method for atomic absorption spectroscopy of an analyte which is contained in a sample to be analyzed and which is converted into free atoms in an absorption volume of an atomizer, said method comprising the steps of (a) position- and time-dependent measuring of the atomic absorption over the cross-section of the absorption volume and (b) simultaneous determination of surface temperatures of the atomizer.Type: GrantFiled: January 21, 1997Date of Patent: May 21, 2002Assignee: PerkinElmer Instruments LLCInventors: Michael Sperling, Albert Gilmutdinov
-
Patent number: 6346418Abstract: A method for evaluating ratios of metallic impurities in lithographic materials is disclosed. The method comprises: separating said metal from said lithographic material by microwave heating; then adding said metal to an acid to form a solution; and finally analyzing said solution by a instrument to measure ratio of said metal.Type: GrantFiled: September 2, 1999Date of Patent: February 12, 2002Assignee: Mosel Vitelic Inc.Inventors: Hui-An Chang, Bor-Jen Cheng, Yu-Chuan Lin
-
Patent number: 6146898Abstract: An apparatus and method for on-line decomposition of a hydrogen peroxide solution, for use in fabricating a semiconductor device, includes a membrane tube having a porous plug inserted in each end, with the porous plugs defining a space where a platinum catalyst is disposed. A first coupling tube is inserted into one end of the membrane tube to supply a hydrogen peroxide sample to the membrane tube. The hydrogen peroxide contained in hydrogen peroxide sample is decomposed into water and oxygen gas according to an action of the platinum catalyst. A second coupling tube is inserted into a second end of the membrane tube to discharge a diluted hydrogen peroxide solution to an analytical instrument, where the decomposed hydrogen peroxide solution is analyzed on-line.Type: GrantFiled: September 22, 1998Date of Patent: November 14, 2000Assignee: Samsung Electronics Co., Ltd.Inventors: Sung-chul Kang, Dong-soo Lee
-
Patent number: 6143569Abstract: A polyfunctional amine, such as cyclam, substituted with 4-(N,N-dimethylao) benzonitrile, exhibits triple fluorescence and complexes with metal ions. The complexation of metal ions with the fluorophore changes the triple fluorescence characteristics of the fluorophore. Thus, this substituted polyfunctional amine provides an effective indicator for the qualitative and quantitative detection of metals.Type: GrantFiled: August 31, 1998Date of Patent: November 7, 2000Assignee: The United States of America as represented by the Secretary of the NavyInventors: Greg E. Collins, Ling-Siu Choi
-
Patent number: 6140138Abstract: A chemical moiety is disclosed which comprises a chemical, biochemical, or biological substance attached to one or more electrochemiluminescent organometallic compounds. In a preferred embodiment of the invention the substance is attached to one or more ruthenium-containing or osmium-containing luminescent organometallic compounds. Methods are disclosed for detecting low concentrations of the chemical moiety using chemiluminescent, electrochemiluminescent, and photoluminescent means. Compounds are disclosed which are useful for labeling substances of interest with ruthenium-containing and osmium-containing labels or other electrochemiluminescent labels. These labeled substances are useful in methods provided for detecting and quantifying analytes of interest in binding assays and competitive binding assays. The labeled substances are of particular use in homogeneous binding assays.Type: GrantFiled: May 4, 1994Date of Patent: October 31, 2000Assignee: IGEN International Inc.Inventors: Allen J. Bard, George M. Whitesides
-
Patent number: 6037182Abstract: A method is used to detect a location of contaminant entry in a processing fluid production and distribution system. A wafer is placed in a clean container. The clean container is connected to a test point within the processing fluid production and distribution system. Processing fluid from the test point of the processing fluid production and distribution system is allowed to flow through the clean container. The wafer is dried. The wafer is then tested for the existence of contaminants.Type: GrantFiled: December 29, 1997Date of Patent: March 14, 2000Assignee: VLSI Technology, Inc.Inventor: John A. Weems
-
Patent number: 6033912Abstract: A system and method for controlling a microwave heated chemical process is disclosed. Time varying concentrations of some chemical substances within fumes in the microwave oven are monitored to detect concentration variations for which responses are known. Responses to the detected variations are initiated to control the chemical process without terminating the process. Examples of responses include varying microwave radiation energy, initiating safety systems, increased venting of the microwave oven, and so forth.Type: GrantFiled: November 13, 1997Date of Patent: March 7, 2000Assignee: Milestone S.r.l.Inventor: Werner Lautenschlager
-
Patent number: 6030840Abstract: A method for the spectroscopic determination of a marker comprises:(a) contacting chelated lanthanide metal ions bound to a marker with a buffered solution comprising a detergent, an enhancer reagent and a polyanion, wherein the buffer maintains the pH of the solution within the range of about 3.5 to about 11.5 and the polyanion is present in sufficient concentration such that the lanthanide metal ion disassociates from the chelate complex and reassociates with the enhancer reagent, thereby transferring the lanthanide metal ion into fluorescent form; and(b) determining the amount of lanthanide metal ion liberated from the marker as a measure of the amount of marker present by subjecting the solution to a short radiation pulse and detecting the fluorescence of the lanthanide metal ion after the fluorescence from any background sources substantially has ceased.Type: GrantFiled: June 15, 1998Date of Patent: February 29, 2000Assignee: NEN Life Sciences, Inc.Inventors: Thomas Robert Mullinax, Margaret R. Cody, Mark N. Bobrow
-
Patent number: 5993664Abstract: A method for producing a material for heavy metal absorption or for analytically detecting heavy metals, especially uranium and radium, comprises the steps of: providing a material containing nitrogen which is organically bonded in a polymer; treating said material with potassium permanganate in an alkaline solution; and treating the material with iron(II) hydroxide in an alkaline solution. The material produced in this way is suitable for being used for a method of analytically detecting heavy metals and heavy metal istopes in a sample liquid as well as for a method of cleaning contaminated liquids.Type: GrantFiled: July 21, 1997Date of Patent: November 30, 1999Assignee: Thomas StreilInventors: Thomas Streil, Wolfram Grundke, Gunther Just
-
Patent number: 5985356Abstract: Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc.Type: GrantFiled: October 18, 1994Date of Patent: November 16, 1999Assignees: The Regents of the University of California, Symyx TechnologiesInventors: Peter G. Schultz, Xiaodong Xiang, Isy Goldwasser
-
Patent number: 5972711Abstract: A method for microwave assisted chemical processes is disclosed that comprises applying sufficient microwave radiation to a temperature-monitored mixture of reagents, with at least one of the reagents being thermally responsive to electromagnetic radiation in the microwave range, and based on the monitored temperature, to maintain the added reagents at or closely about a predetermined temperature while substantially avoiding thermal dilution (or before substantial thermal dilution can occur) that otherwise would have been caused by the addition of the reagents to one another.Type: GrantFiled: July 22, 1998Date of Patent: October 26, 1999Assignee: CEM CorporationInventors: David A. Barclay, William Edward Jennings, Edward E. King
-
Patent number: 5945342Abstract: The present invention relates to methods for digesting diphosphonic acid substituted cation exchange resins that have become loaded with actinides, rare earth metals, or heavy metals, in a way that allows for downstream chromatographic analysis of the adsorbed species without damage to or inadequate elution from the downstream chromatographic resins. The methods of the present invention involve contacting the loaded diphosphonic acid resin with concentrated oxidizing acid in a closed vessel, and irradiating this mixture with microwave radiation. This efficiently increases the temperature of the mixture to a level suitable for digestion of the resin without the use of dehydrating acids that can damage downstream analytical resins. In order to ensure more complete digestion, the irradiated mixture can be mixed with hydrogen peroxide or other oxidant, and reirradiated with microwave radiation.Type: GrantFiled: May 18, 1998Date of Patent: August 31, 1999Assignee: Westinghouse Savannah River CompanyInventors: Sherrod L. Maxwell, III, Sheldon T. Nichols
-
Patent number: 5877164Abstract: The present invention provides rhamnogalacturonan-II (RG-II) and relates to its ability to complex specific multivalent heavy metal cations. In the presence of boric acid, RG-II monomers form dimers that are cross-linked by a borate ester. The yield of such borate ester cross-linked dimers of RG-II is enhanced in the presence of specific heavy metal cations. The present invention further relates to the utility of RG-II in assays for the detection of specific heavy metal contamination; as a reagent useful in the removal of specific heavy metal cations contaminating foods and liquids, for example, fish, wines, etc.; as a pharmaceutical composition useful as an antidote in specific heavy metal cation poisoning; as a treatment for the detoxification of specific heavy metal cations from blood and/or tissues; and in a method of remediation of waters and soils contaminated with specific heavy metal cations.Type: GrantFiled: November 22, 1996Date of Patent: March 2, 1999Assignees: University of Georgia Research Foundation, Inc., Institute National de la Recherche AgronomiqueInventors: Malcolm A. O'Neill, Patrice J. M. Pellerin, Dennis Warrenfeltz, Stephane Vidal, Alan G. Darvill, Peter Albersheim
-
Patent number: 5858676Abstract: Luminescent chemical reagents that include complexes of rare earth metals with ligands such as aromatic heterocyclic nitrogen-containing compounds and semi-aromatic oxygen-containing compounds are used to detect small quantities of complex substances such as pharmaceuticals, metabolites, and microorganisms in complex sample mixtures.Type: GrantFiled: July 10, 1997Date of Patent: January 12, 1999Assignee: IGEN International, Inc.Inventors: Hongjun Yang, Nicholas Cairns
-
Patent number: 5840583Abstract: A method for microwave assisted chemical processes is disclosed that comprises applying sufficient microwave radiation to a temperature-monitored mixture of reagents, with at least one of the reagents being thermally responsive to electromagnetic radiation in the microwave range, and based on the monitored temperature, to maintain the added reagents at or closely about a predetermined temperature while substantially avoiding thermal dilution (or before substantial thermal dilution can occur) that otherwise would have been caused by the addition of the reagents to one another.Type: GrantFiled: September 5, 1997Date of Patent: November 24, 1998Assignee: CEM CorporationInventors: David A. Barclay, William Edward Jennings, Edward E. King
-
Patent number: 5834316Abstract: A method of extracting anionic species from a solid or liquid medium by contacting the medium with an extract solvent of supercritical carbon dioxide and a positively charged complexant ligand for solubilizing and extracting the anionic species form the medium.Type: GrantFiled: April 25, 1996Date of Patent: November 10, 1998Assignee: British Nuclear Fuels plcInventors: Neil Graham Smart, Robert George Godfrey Holmes, Nigel Dennis Tinker, Michael Darbyshire
-
Patent number: 5830769Abstract: Homogeneous assays for determining quantitatively the extent of a specific binding reaction can be carried out effectively on very dilute solutions using measurements of fluorescence if a fluorescence measurement scheme that is capable of rejecting short-lived background fluorescence is employed and if the fluorescent group being measured has the following properties: a. the group being measured must be a rare earth metal chelate complex combination; b. the chelate must be water-soluble; c. the complex combination must also be stable in extremely dilute aqueous solutions, that is, the measured chelate must have at least one ligand having a metal-to-ligand binding constant of at least about 10.sup.13 M.sup.-1 or greater and it must have a fluorescent emission that is long-lived compared to the longest decay lifetime of ambient substances and have a half life of from 0.01 to 50 msec.Type: GrantFiled: October 15, 1996Date of Patent: November 3, 1998Inventors: Irwin Wieder, Ron L. Hale
-
Patent number: 5792663Abstract: Fractional-volatilization separation systems and methods are disclosed which enable a stable, continuous, non-bubbling liquid flow, essentially constant surface area/volume ratio, temperature controlled, fractional volatilization of volatile/semi-volatile components in a liquid analyte or component containing sample. The fractional volatilization separator system can be utilized in small scale analytical and large scale chemical purification, concentration and desalinization applications. Continuous rapid removal of residual liquid sample can provide concentrated non-volatile component/analyte solution, and allows quick and easy washout between sequential use with different liquid samples.Type: GrantFiled: September 27, 1996Date of Patent: August 11, 1998Assignee: Transgenomic IncorporatedInventors: Robert C. Fry, Michael R. Dyas, Jason A. Rivers, Robert M. Brown, Jr.
-
Patent number: 5747349Abstract: The present invention provides a method and apparatus for rapid measurement of a fluid bulk analyte, requiring only microscale volumes. Several fluid bulk analytes can be measured simultaneously and, for biological samples, the cell content can also be measured simultaneously. The invention comprises reporter beads for chemical analysis of fluid bulk properties such as pH, oxygen saturation and ion content. Each reporter bead comprises a substrate bead having a plurality of at least one type of fluorescent reporter molecules immobilized thereon. The fluorescent properties of the reporter bead are sensitive to a corresponding analyte. Reporter beads are added to a fluid sample and the analyte concentration is determined by measuring fluorescence of individual beads, for example in a flow cytometer. Alternatively, reporter molecules which change absorbance as a function of analyte concentration can be employed.Type: GrantFiled: March 20, 1996Date of Patent: May 5, 1998Assignee: University of WashingtonInventors: Ger van den Engh, Bernhard H. Weigl
-
Patent number: 5731147Abstract: A chemical moiety is disclosed which comprises a chemical, biochemicals, or biological substance attached to one or more electrochemiluminescent organometallic compounds. In a preferred embodiment of the invention the substance is attached to one or more ruthenium-containing or osmium-containing luminescent organo-metallic compounds. Methods are disclosed for detecting low concentrations of the chemical moiety using chemiluminescent, electrochemiluminescent, and photo-luminescent means. Compounds are disclosed which are useful for labeling substances of interest with ruthenium-containing and osmium-containing labels or other electrochemiluminescent labels. These labeled substances are useful in methods provided for detecting and quantifying analytes of interest in binding assays and competitive binding assays. The labeled substances are of particular use in homogeneous binding assays.Type: GrantFiled: June 7, 1995Date of Patent: March 24, 1998Assignee: Igen International, Inc.Inventors: Allen J. Bard, George M. Whitesides
-
Patent number: 5648270Abstract: The present invention describes the use of a family of fluorescent indicators for metal cations. The indicators are fluorophore conjugates of pyridyl-based metal ion chelators. The indicators are very sensitive detection as quantification reagents for a variety of metals, in a variety of oxidation states, even in the presence of high concentrations of Ca.sup.2+, Na.sup.+, or K.sup.+ or other ions, such as is found in seawater, making them highly useful for assaying physiological samples, biological samples, or environmental samples.Type: GrantFiled: February 6, 1995Date of Patent: July 15, 1997Assignee: Molecular Probes, Inc.Inventors: Michael A. Kuhn, Richard P. Haugland, Brian Matthew Hoyland
-
Patent number: 5637506Abstract: A method of radiochemical analysis having the steps of providing a solid phase extraction sheet material containing ion-specific sorptive or reactive particles in a porous matrix as carrier for the particles, and providing a fluid including an ion-containing radiochemical analyte, contacting the sheet material with the fluid for a time sufficient for the particles to selectively extract the analyte from the fluid, and analyzing the sheet material in a direct mode for quantitative or qualitative data relating to the radiochemical analyte. Solid phase extraction sheet materials and methods for their preparation are also disclosed.Type: GrantFiled: April 15, 1996Date of Patent: June 10, 1997Assignee: Minnesota Mining and Manufacturing CompanyInventors: Garold L. Goken, Wolfgang H. Strehlow
-
Patent number: 5622821Abstract: The invention provides lanthanide chelates capable of intense luminescence. The celates comprise a lanthanide chelator covalently joined to a coumarin-like or quinolone-like sensitizer. Exemplary sensitzers include 2- or 4-quinolones, 2- or 4-coumarins, or derivatives thereof e.g. carbostyril 124 (7-amino-4-methyl-2-quinolone), coumarin 120 (7-amino-4-methyl-2-coumarin), coumarin 124 (7-amino-4-(trifluoromethyl)-2-coumarin), aminomethyltrimethylpsoralen, etc.The chelates form high affinity complexes with lanthanides, such as terbium or europium, through chelator groups, such as DTPA. The chelates may be coupled to a wide variety of compounds to create specific labels, probes, diagnostic and/or therapeutic reagents, etc. The chelates find particular use in resonance energy transfer between chelate-lanthanide complexes and another luminescent agent, often a fluorescent non-metal based resonance energy acceptor.Type: GrantFiled: June 29, 1994Date of Patent: April 22, 1997Assignee: The Regents of the University of CaliforniaInventors: Paul R. Selvin, John Hearst
-
Patent number: 5561066Abstract: Organic and inorganic contaminants of an environmental sample are analyzed by the same GC-MS instrument by adding an oxidizing agent to the sample to oxidize metal or metal compounds to form metal ions. The metal ions are converted to chelate complexes and the chelate complexes are extracted into a supercritical fluid such as CO.sub.2. The metal chelate extract after flowing through a restrictor tube is directly injected into the ionization chamber of a mass spectrometer, preferably containing a refractory metal filament such as rhenium to fragment the complex to release metal ions which are detected. This provides a fast, economical method for the analysis of metal contaminants in a sample and can be automated. An organic extract of the sample in conventional or supercritical fluid solvents can be detected in the same mass spectrometer, preferably after separation in a supercritical fluid chromatograph.Type: GrantFiled: April 20, 1995Date of Patent: October 1, 1996Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventor: Mahadeva P. Sinha
-
Patent number: 5561052Abstract: There are disclosed a process for detecting and determining an oxidized lipid in a specimen, which is capable of readily and accurately determining a specimen as containing an oxidized lipid, and a process for forming a water-soluble oxidized lipid having a hydroperoxide group which has specific influence on a living body. A specimen is detected and determined to contain an oxidized lipid by adding a lanthanide shift reagent to a specimen, followed by spectroscopic analysis thereof. An oxidized lipid is formed by adding superoxide dismutase (SOD) and CuSO.sub.4 to (1) an emulsion prepared by dissolving linoleic acid or arachidonic acid in deuterated methyl alcohol and adding the solution to a deuterated phosphate buffer under stirring, or to (2) a low density lipoprotein solution sufficiently dialyzed against an undeuterated phosphate buffer; followed by irradiation with long-wave ultraviolet light.Type: GrantFiled: May 19, 1995Date of Patent: October 1, 1996Inventor: Katsumasa Koike
-
Patent number: 5472878Abstract: A method for the qualitative or quantitative determination of the deleterious agent in a substantially non-aqueous medium, such as an oil. The method involves using a non-azo 1,8-naphthalimide dye for the detection or quantitation of the total hydrogen ion activity in a substantially non-aqueous medium. The method includes the steps of: Mixing the dye with the substantially non-aqueous medium, which may or may not contain any hydrogen ion, to form a mixture; irradiating the mixture with a fluorescent light sufficient to cause the mixture to emit a detectable fluorescent emission spectrum; detecting the fluorescent emission spectrum of the mixture; and comparing the detected fluorescent emission spectrum with standard fluorescent emission spectra generated by reacting the dye with different known hydrogen ion activities, wherein differences between the fluorescent emission spectra compared are dependent upon the presence or levels of the hydrogen ion activity present in the mixture.Type: GrantFiled: June 8, 1994Date of Patent: December 5, 1995Assignee: MicroBioMed Corp.Inventors: David E. Lewis, Ronald E. Utecht, Millard M. Judy, J. Lester Matthews
-
Patent number: 5308773Abstract: The use of a class of non-azo 1,8-naphthalimide dyes for the detection and quantitation of a paramagnetic metal cation in a non-aqueous medium and some of the dyes that will complex with a paramagnetic metal cation. The concentration of the paramagnetic metal cation is determined by monitoring differences in the detected fluorescent emission spectra of the non-azo 1,8-naphthalimide dye solution when it is mixed with paramagnetic metal cations present in the non-aqueous medium. The detected fluorescent emission spectra will vary in relation to the presence or amount of the paramagnetic metal cation in the mixture.Type: GrantFiled: November 16, 1992Date of Patent: May 3, 1994Assignee: MicroBioMed Corp.Inventors: David E. Lewis, Ronald E. Utecht, Millard M. Judy, J. Lester Matthews
-
Patent number: 5256535Abstract: A method for the detection of a nucleotide sequence of a nucleic acid in a sample. The method comprises the steps: (i) contacting under hybridization condition the single stranded form of the nucleotide sequence with a single stranded nucleic acid probe, in which plurality of rare earth metal chelate groups is covalently linked via a water-soluble polymer of non-nucleic acid structure to a nucleotide acid that as one of its strand has the nucleotide sequence to be detected and as the other strand the nucleotide sequence of the probe, and (ii) detecting the formation of double stranded nucleic acid. The plurality of rare earth metal chelate groups have at least one metal ion selected from the group consisting of Eu.sup.3+, Sm.sup.3+, Tb.sup.3+ and Dy.sup.3+ as the chelated rare earth metal. The probes as given above are also claimed.Type: GrantFiled: June 16, 1988Date of Patent: October 26, 1993Inventors: Jyrki Ylikoski, Pertti Hurskainen, Patrik Dahlen, Christian Sund, Timo Lovgren, Marek Kwjatkowski
-
Patent number: 5215664Abstract: A method of separating rare earth elements and compounds from mixtures containing the same which comprises separating the rare earth elements and compounds by means of rotational high speed countercurrent chromatography.Type: GrantFiled: May 18, 1992Date of Patent: June 1, 1993Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Eiichi Kitazume, Yoichiro Ito
-
Patent number: 5190881Abstract: A method of determining the radioactivity of specific actinides that are carried in urine or fecal sample material is disclosed. The samples are ashed in a muffle furnace, dissolved in an acid, and then treated in a series of steps of reduction, oxidation, dissolution, and precipitation, including a unique step of passing a solution through a chloride form anion exchange resin for separation of uranium and plutonium from americium.Type: GrantFiled: February 4, 1992Date of Patent: March 2, 1993Assignee: The United States of America as represented by the United States Department of EnergyInventor: Terry T. McKibbin
-
Patent number: 5126272Abstract: A method for the detection of trace transition elements and rare earth elements in a sample also containing alkali metals or alkaline earth elements. The sample is flowed through a chelator column which retains the transition elements and rare earth elements. Then a first eluent (e.g. ammonium acetate) is passed through the column to strip the alkali and alkaline earth metals retained on the column. Then a second eluent (e.g. a strong acid) is passed through the chelator column to remove the transition elements in a chelator effluent which flows through an ion exchange resin concentrator to retain only the transition elements and rare earth elements. Then, a chelator complexing agent (e.g. pyridine-2,6 dicarboxylic acid or an oxalate) flows through the concentrator column to remove the transition elements and rare earth elements.Type: GrantFiled: March 2, 1989Date of Patent: June 30, 1992Assignee: United States of AmericaInventors: Howard M. Kingston, Jr., John M. Riviello, Archava Siriraks
-
Patent number: 5118628Abstract: A method for analyzing water or other liquid, in particular rain water, comprises the steps of providing a collector comprising at least first and second volumetric cells and a mechanism for causing water to flow selectively into the cells and for causing water to flow selectively from the cells. Water is caused to flow into a first one of the cells while it is prevented from flowing into the other one of the cells. The water collected in the first cell is caused to flow to a property determining cell when the first cell has been filled to a predetermined volume, and simultaneously water is prevented from flowing into the first cell while it is now permitted to flow into the second volumetric cell. The water collected in the second cell is then permitted to flow to a property determining cell when the second cell has been filled to a predetermined volume, and simultaneously the water is prevented from flowing to the second cell while it is now permitted to flow to the first cell.Type: GrantFiled: October 2, 1987Date of Patent: June 2, 1992Assignee: Kernforschungsanlage Julich GmbHInventors: Peter Krumpen, Britta Landgraf, Hartmut Prast, Bernd Schmitz
-
Patent number: 4970146Abstract: A method of determining the amount of nutriment absorbed in living organisms comprising animals, fish and plants comprises adding to the animal, fish or plant food one or more elements from the lanthanide series as tracers. After the nutriment has been absorbed, a sample is taken from a localized part of the living organism, for example a fish scale, and the sample is analyzed by ICP (inductively coupled plasma) to determine the amount of tracer and thus the amount of absorbed nutriment in the living organism.Type: GrantFiled: September 11, 1987Date of Patent: November 13, 1990Assignee: Havbrukskjemi A/SInventor: Harald Skjervold
-
Patent number: 4968631Abstract: Fluorescent lanthanide chelates are formed by reacting a .beta.-diketone, an aldehyde, and an amine to produce a dihydropyridine condensation product which is then chelated with a lanthanide metal ion. These fluorescent chelates are made into wavelength-shifting devices by physically supporting the chelates on a polymer. Such wavelength-shifting devices can be optically coupled to a photoelectric cell to increase the portion of the solar spectrum available to the cell for conversion into electricity. Furthermore, the reaction producing the fluorescent lanthanide chelates is used to detect amines or aldehydes in a sample.Type: GrantFiled: September 29, 1989Date of Patent: November 6, 1990Assignee: Golight, Inc.Inventor: Salifu Dakubu
-
Patent number: 4876206Abstract: This invention relates to methods for quickly and accurately detecting the presence of rare earth minerals which can be performed in the field. An ore sample to be tested for the presence of rare earth minerals is contacted with both a basic reagent, preferably containing an alkali metal, and with a halide acid such as hydrochloric acid. Once the treated ore sample is dry, it is examined under a shortwave ultraviolet light for fluorescence of a red-orange color. If rare earth minerals are present, fluorescence of a red-orange color will occur. If no rare earth minerals are present, no red-orange fluorescence is observed. The sensitivity of the disclosed methods to rare earth minerals may be varied by altering the basic reagent to permit the user to "zero in" on the most concentrated source of rare earth minerals.Type: GrantFiled: February 10, 1989Date of Patent: October 24, 1989Inventor: Wayne L. Sayer