Mn, Te, Re, Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt Patents (Class 436/84)
  • Patent number: 11573241
    Abstract: The present invention relates to a novel use of total cellular iron, preferably under the form of ferrous iron (Fe2+), as a marker of cancer stem cells (CSCs). The invention also relates to methods using said iron marker, in particular for metastatic cancer diagnosis or treatment, for screening for compounds of interest, as well as for killing CSCs.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: February 7, 2023
    Assignees: Institute National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université de Paris
    Inventors: Maryam Mehrpour, Raphael Rodriguez, Ahmed Hamai, Trang Mai
  • Patent number: 10100301
    Abstract: The present invention relates to monodisperse silanized ferrimagnetic iron oxide particles, a method for producing the same and a method for independent generic binding of nucleic acid molecules to the particles.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: October 16, 2018
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Jens Christian Bolle, Thomas Walter, Peter Wenzig
  • Patent number: 9834660
    Abstract: There is provided rare earth metal complexes of formula (I): wherein M is a cation, RE is a rare earth metal; X is a counter anion; and R1, R2, R3, and R4 are each independently selected from hydrogen, alkyl of 1-8 carbon atoms, aryl, halo, and alkoxy. Also provided is a composition of europium bis(2,2?-bipyridine-N,N?)-trinitrate with a diketonate dopant. The disclosure also provides processes for preparing the rare earth metal complexes. A mark comprising the rare earth metal complexes, and a method of applying the mark, are disclosed. The rare earth metal complexes may be used in printing systems, and for security applications.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: December 5, 2017
    Assignee: HONEYWELL INTERNATIONAL INC.
    Inventors: Thomas Potrawa, Joachim Schulz
  • Patent number: 9488633
    Abstract: The present invention relates to a method for determining the concentration of iron ions in a hydrocarbon composition, as well as reagents and kits for use in such methods. The method utilises a thiocarboxylic acid having formula (I) which reduces the ferric ions and complexes ferrous ions producing a colored solution, which can be analysed to determine the amount of iron ions in the starting sample.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: November 8, 2016
    Assignee: Kittiwake Developments Ltd.
    Inventor: David Atkinson
  • Patent number: 9188590
    Abstract: The invention relates to a labeled transition metal complex comprising a transition metal atom, a reactive moiety for allowing a chemical or biological entity to become attached to the transition metal atom, an inert tridentate moiety as a stabilizing bridge, and a marker. The invention also relates to a labeled chemical or biological entity comprising a chemical or biological entity which is attached to said labeled transition metal complex, to the use of said complex for creating a defined shift in the molecular mass of said entity in order to facilitate mass spectrometric analysis of said entity, to methods for rendering chemical or biological entities distinguishable by mass spectrometry as well as to methods for mass spectrometric analysis of the chemical or biological entities.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: November 17, 2015
    Assignee: LEICA BIOSYSTEMS NEWCASTLE LTD.
    Inventors: Marie Lacombe, Franciscus Johannes Opdam, Eduard Gerhard Talman, Jacky Theo Maria Veuskens
  • Patent number: 9063109
    Abstract: Compositions containing polyanthrylene and methods of making these compositions are disclosed herein. The polyanthrylene composition can, for example, be used for detection of iron in a sample.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: June 23, 2015
    Assignee: Tongji University
    Inventors: Mei-rong Huang, Shao-jun Huang, Jiang-Ling Li, Xin-gui Li
  • Patent number: 9005983
    Abstract: The present invention provides an electrochemical sensor having a solid electrically conductive substrate and a compound immobilized thereon which has binding affinity for an analyte species to be detected and also displays electrochemical behavior which is modified upon binding of that analyte species, so that binding of an analyte species can be detected by measuring electrochemical properties, such as by voltammetry. Desirably the immobilized compound contains both a first moiety with binding affinity for the analyte and a separate second moiety which is a redox system whose electrochemical oxidation/reduction properties become modified when the first moiety binds the analyte. The analyte binding moiety may be a diol or polyol and preferably is a sugar. The electrochemical sensor finds use in methods of analyzing reservoir and process fluids, particularly at a subterranean location. The electrochemical sensor may be a component of a downhole tool, adapted for deployment downhole.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: April 14, 2015
    Assignee: Schlumberger Technology Corporation
    Inventors: Kay McGuinness, Nathan Lawrence, Andrew Meredith
  • Patent number: 8980639
    Abstract: The present invention is concerned with a method of discriminating between, in a surface of a transition metal alloy, transition metals in different oxidation states using surface sensor molecules adapted to associate selectively with one of the transition metals. In particular, the present invention provides a method of identifying degradation in aircraft components such as turbine blades, engine casings and aerofoils. In embodiments, a surface sensor molecule comprising an oxidation state discriminating group, such as an imidazole, and a fluorescein probe is applied in aqueous solution to the surface of a service-run Ni alloy aircraft component. The sensor molecule selectively associates with transition metals in oxidation states greater than zero such that fluorescence imaging can be used to identify areas of degradation.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: March 17, 2015
    Assignee: Rolls-Royce PLC
    Inventors: Daniel Clark, Justin Burrows
  • Patent number: 8975082
    Abstract: Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal orientation or both; and wherein C1 and C2 are the same or different; and wherein C1 and C2 individually are chosen from a cysteine and a cysteine-like nonnatural amino acid, as well as metal-XC1C2 complexes and methods for forming such complexes.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: March 10, 2015
    Assignee: University of Kansas
    Inventors: Jennifer Ann Stowell Laurence, Anthony Andrew Vartia, Mary Elizabeth Krause
  • Patent number: 8962339
    Abstract: The present invention discloses a fluorescent probe compound which solved the problem of fluorescence quenching by Pd2+, and its preparation method and use as well. Excitation and emission wavelengths of the probe compound are in visible light region. The probe compound is highly sensitive and displays good selectivity for Pd2+ in near-neutral pH range. In detection of Pd2+ in 0-10 ppb level, fluorescence is evidently enhanced, and Pd2+ in the level as low as 5 nM can be detected. Fluorescence intensity is well linearly correlated to Pd2+ concentration. The probe compound can be used for detection of contaminating palladium and residual palladium in drug, soil, water sample and reactor.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: February 24, 2015
    Assignees: Dalian University of Technology, Dalian Chromas Bioscience Co., Ltd.
    Inventors: Xiaojun Peng, Jiangli Fan, Honglin Li, Jingyun Wang, Shiguo Sun
  • Patent number: 8945937
    Abstract: A method of analyzing graphene includes providing a first graphene structure including graphene having grains and grain boundaries, and a support portion for supporting the graphene, generating a second graphene structure by oxidizing the first graphene structure, and detecting a shape of the graphene.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: February 3, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Young-hee Lee, Gang-hee Han, Dinh Loc Duong
  • Patent number: 8940542
    Abstract: A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: January 27, 2015
    Assignee: Lighthouse Medical Limited
    Inventors: William Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
  • Publication number: 20150004710
    Abstract: Reagents and methods are disclosed for detection of oxidizers and inorganic salts and other analytes of interest. The reagents can interact with their target analytes, especially oxidizer compositions or oxidizer-based explosives, to selectively enhance their ionization yield, interacting by chemical reaction or by forming an associative adduct which facilitates their detection. For example, the reagents can adduct with the counter-ion of the intended analyte for improved direct detection and/or react chemically via acid-base reactions to produce a new product for detection. In another aspect of the invention, reactive reagents and methods are also disclosed that facilitate indirect detection of the analyte at lower temperatures based on reduction-oxidation (redox) chemistry. These reagents are particularly useful in detecting oxidizer analytes.
    Type: Application
    Filed: July 23, 2013
    Publication date: January 1, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: Kerin E. Gregory, Roderick R. Kunz, Michael Sworin
  • Patent number: 8871523
    Abstract: Disclosed is a sensor for detecting explosive devices. The sensor includes a ferromagnetic metal and a molecular recognition reagent coupled to the ferromagnetic metal. The molecular recognition reagent is operable to expand upon absorption of vapor from an explosive material such that the molecular recognition reagent changes a tensile stress upon the ferromagnetic metal. The explosive device is detected based on changes in the magnetic switching characteristics of the ferromagnetic metal caused by the tensile stress.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 28, 2014
    Assignee: Consolidated Nuclear Security, LLC
    Inventors: Vincent E. Lamberti, Layton N. Howell, Jr., David K. Mee, Michael J. Sepaniak
  • Patent number: 8828734
    Abstract: Provided are a nitric oxide detection element capable of detecting NO gas contained in a mixed gas at a high speed even when the amount thereof is a super trace amount of ten and several parts per billion; and a process for producing the element. In a nitric oxide detection element having a substrate 12 and a sensing film 11 formed on a surface of the substrate, the sensing film is composed of nitric oxide sensing particles and a polymer adhesive. The nitric oxide sensing particles are produced by adsorbing a dye having a porphyrin skeleton and having, as a central metal, divalent cobalt onto surfaces of inorganic particles.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: September 9, 2014
    Assignees: Panasonic Healthcare Co., Ltd., National University Corporation Ehime University
    Inventors: Kouichi Hiranaka, Toyofumi Nagamatsu, Yoshihiko Sadaoka, Yoshiteru Itagaki
  • Publication number: 20140220695
    Abstract: Compositions containing polyanthrylene and methods of making these compositions are disclosed herein. The polyanthrylene composition can, for example, be used for detection of iron in a sample.
    Type: Application
    Filed: April 11, 2014
    Publication date: August 7, 2014
    Applicant: Tongji University
    Inventors: Mei-rong Huang, Shao-jun Huang, Jiang-Ling Li, Xin-gui Li
  • Publication number: 20140213597
    Abstract: The invention provides methods for treatment of acute coronary syndrome and prediction of adverse cardiac events on the basis of elevations of catalytic iron in biological fluid of a human subject. An embodiment of the invention provides a method for early detection of acute coronary syndrome (ACS) in a human subject at the time of presentation of the chest pain. The method includes analyzing a test sample of the biological fluid for amount of catalytic iron and detecting acute coronary syndrome in the human subject.
    Type: Application
    Filed: March 27, 2014
    Publication date: July 31, 2014
    Inventors: Mohan Rajapurkar, Suhas Lele, Sudhir Shah
  • Patent number: 8765480
    Abstract: A method for recovering a metal, capable of recovering a metal easily without requiring the use of an organic medium, is provided. A first complex between a first chelating agent and a metal present in a sample is formed in a first mixture prepared by mixing the first chelating agent and the sample. Then, the first complex is recovered from the first mixture, and a second complex between the metal derived from the first complex and a second chelating agent is formed in a second mixture prepared by mixing the first complex and an aqueous solution of the second chelating agent. The aqueous solution is under the pH conditions where the first chelating agent can be insoluble in the aqueous solution. Then, a liquid fraction containing the second complex is recovered from the second mixture. Thus, the metal can be recovered.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: July 1, 2014
    Assignee: ARKRAY, Inc.
    Inventor: Yuka Shimomura
  • Patent number: 8741658
    Abstract: A method and devices analyze for the presence of cyanide in samples using colorimetric analysis of samples after contacting with cobinamide or monocyanocohinapmide.
    Type: Grant
    Filed: March 15, 2011
    Date of Patent: June 3, 2014
    Assignees: The Regents of the University of California, Board of Regents, The University of Texas System
    Inventors: Gerry Boss, Vijay Sharma, Matthew Brenner, Purnendu K. Dasgupta, William Curt Blackledge
  • Patent number: 8652849
    Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: February 18, 2014
    Assignee: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Alicja M. Mika, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
  • Patent number: 8623661
    Abstract: The present invention provides an iron chelating agent which can selectively chelate iron ions. The iron chelating agent of the present invention includes a compound represented by the following formula (1) or a salt thereof (wherein, ring Z represents an aromatic hydrocarbon ring or an aromatic heterocyclic ring; R1 represents an alkylene group; R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group or a group having chelating ability; and the total coordination number of the groups represented by R2 and R3 is 1 or 2.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: January 7, 2014
    Assignees: National University Corporation Asahikawa Medical College, Yamagata University
    Inventors: Yutaka Kohgo, Katsuya Ikuta, Katsunori Sasaki, Yuzo Nishida
  • Publication number: 20130330293
    Abstract: The present invention concerns bio-nano power cells and methods of their manufacture and use. More particularly, the present invention relates to the preparation of bio-nano power cells that are biocompatible and capable of producing flash, intermittent, or continuous power by electrolyzing compounds in biological systems.
    Type: Application
    Filed: September 2, 2009
    Publication date: December 12, 2013
    Applicant: BIO-NANO POWER
    Inventors: Nathan R. Long, Jie Wang, Hosam Gharib Abdelhady
  • Patent number: 8603830
    Abstract: The present invention relates to a method for the determination of polysorbate in a protein-containing sample. The method of the present invention involves the pretreatment of the sample by alkaline hydrolysis followed by colorimetric determination.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: December 10, 2013
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Alfred Weber, Andrea Engelmaier, Heinz Anderle, Hans-Peter Schwarz
  • Publication number: 20130296257
    Abstract: The present invention relates to a cobalamin acquisition protein, compositions containing the cobalamin acquisition protein, and the use of such compositions.
    Type: Application
    Filed: April 30, 2013
    Publication date: November 7, 2013
    Inventor: Woods Hole Oceanographic Institution
  • Patent number: 8557592
    Abstract: The present invention provides a reagent kit for detecting lupus anticoagulant which includes a first clotting time-measuring reagent containing manganese salt and a second clotting time-measuring reagent which contains manganese salt at a concentration lower than that of the first clotting time-measuring reagent or does not contain manganese salt and a method of determining the presence or absence of lupus anticoagulant using the kit.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: October 15, 2013
    Assignee: Sysmex Corporation
    Inventors: Masahiro Okuda, Kazuyo Yoshida, Osamu Kumano
  • Publication number: 20130230928
    Abstract: A method for measuring iron concentration that includes providing a sensor including a substrate, a ferrozine containing reagent, and a polymer covalently bonding the ferrozine containing reagent on the substrate. The sensor is inserted into an iron (Fe) containing sample. The ferrozine containing reagant reacts with iron (Fe) ions in the iron (Fe) containing sample. The optical properties of the sensor are measured after the ferrozine containing reagent reacts with the iron (Fe) ions in the iron (Fe) containing sample to determine the concentration of the iron (Fe) ions in the iron (Fe) containing sample.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 5, 2013
    Inventors: Qingzhi Zhu, Robert Aller
  • Patent number: 8507094
    Abstract: The present invention relates to a composite bead and a fabrication method thereof, and particularly, to a porous composite bead comprising superparamagnetic cluster and nanoparticles, such as light-emitting nanoparticles, magnetic nanoparticles, metallic nanoparticles, metal oxide nanoparticles and the like, and a fabrication method thereof.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: August 13, 2013
    Assignee: Korea Institute of Science and Technology
    Inventors: Kyoungja Woo, Wooyoung Park
  • Patent number: 8492158
    Abstract: Disclosed are tri-nuclear metal complexes and salts thereof, such as tri-nuclear osmium or ruthenium complexes or salts thereof, suitable for use as electrochemical labels. Also disclosed are oligonucleotide probes with an attached electrochemical label, methods of nucleic acid amplification, methods of sequencing, and kits for nucleic acid amplification and sequencing having oligonucleotide probes including an electrochemical label. The electrochemical labels are synthesized from siderophores.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: July 23, 2013
    Assignee: Applied Biosystems, LLC
    Inventor: Robert G. Eason
  • Patent number: 8481324
    Abstract: The present invention provides a system containing an array of chemically sensitive sensors based on coated single walled carbon nanotubes, for measuring volatile organic compounds indicative of renal failure. Methods of breath analysis for diagnosing chronic, acute and end-stage renal failure are disclosed.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: July 9, 2013
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Hossam Haick, Zaid Abassi, Farid Nakhoul
  • Publication number: 20130157375
    Abstract: In one aspect, there is provided a fluorescent iron-binding compound bound to a solid phase. Also provided is a method for detecting non-transferrin bound iron in a sample, comprising contacting the sample with a fluorescent iron-binding compound bound to a solid phase and detecting a fluorescent signal derived from the fluorescent iron-binding compound bound to the solid phase, wherein the fluorescent signal is indicative of non-transferrin bound iron levels in the sample. Further provided is use of a fluorescent iron-binding compound bound to a solid phase to detect non-transferrin bound iron in a sample.
    Type: Application
    Filed: April 27, 2011
    Publication date: June 20, 2013
    Applicants: LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE, KING'S COLLEGE LONDON
    Inventors: Robert Hider, Yongmin Ma, Ulrich Schaible, Maria Podinovskaia
  • Patent number: 8460939
    Abstract: A method for separating and purifying the active hematinic species (AHS) present in iron-saccharidic compositions, including AHS such as sodium ferric gluconate complex, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function. The method separates the AHS from one or more excipients and, preferably, lyophilizes the separated AHS. Separation of the AHS permits its analytical quantification, further concentration, purification and/or lyophilization as well as preparation of new and useful products and pharmaceutical compositions, including those useful for the treatment of humans and animals.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: June 11, 2013
    Assignee: Chromaceutical Advanced Technologies, Inc.
    Inventors: Robert A. Beck, Robert A. Mateer, Jr.
  • Publication number: 20130130393
    Abstract: The invention relates to a method of analyzing a plurality of ferromagnetic particles (1). The method comprises the following steps: a) aligning the particles (1) of this plurality in such a manner that each of the particles is oriented substantially in the same direction; b) fixing the particles (1) of said plurality in the alignment; c) exposing the internal regions of the particles (1) as aligned in this way; d) determining the nature of each of the particles and grouping the particles by category as a function of their natures; and e) in each category, determining the metallurgical structure and the chemical composition of one or more of the particles.
    Type: Application
    Filed: April 1, 2011
    Publication date: May 23, 2013
    Applicant: SNECMA
    Inventor: Fabrice Colladon
  • Patent number: 8445702
    Abstract: The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of zinc ions in a sample. The metal chelating moiety of the zinc-binding compound is an analog of the well-known calcium chelator, BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N?,N?-tetraacetic acid), wherein the chelating moiety has been modified from a tetraacetic acid moiety to a tri- di- or monoacetic moiety. This change in acetic acid groups on the metal chelating moiety results in the selective bindings of zinc ions in the presence of calcium ions, both of which are present in biological fluids and intracellular cytosolic fluid and organelles.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: May 21, 2013
    Assignee: Life Technologies Corporation
    Inventor: Kyle Gee
  • Patent number: 8435793
    Abstract: It is an object of the present invention to collect a scarce metal such as iridium from a light-emitting element which is no longer used. A method for collecting a metal is provided in which an organic metal compound which can emit visible light from a triplet excited state at room temperature is heated, or an EL layer of a light-emitting layer containing an organic metal compound which can emit visible light from a triplet excited state at room temperature is dissolved in a solvent to form a solution, and the solution is heated, irradiated with microwaves or treated with acid water. According to the above method, resources of metals such as iridium or platinum, which are scarce metals, can be utilized efficiently.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: May 7, 2013
    Assignee: Semiconductor Energy LaboratoryCo., Ltd.
    Inventors: Ryoji Nomura, Satoshi Seo, Hideko Inoue, Kaoru Kato
  • Publication number: 20130059392
    Abstract: Pyridine-containing polyenes and their applications as metal ion sensors. These polyenes are practically nonluminescent in the solution state but become highly emissive as nanoparticle suspensions in aqueous solutions or thin films in the solid state, due to aggregation-induced emission (AIE). The nanoaggregates of these compounds can work as “turn-off” fluorescent chemosensors for metal ions and display different fluorescence responses to various metal ions. For example, a characteristic red shift in the emission spectra is observed with a terpyridine-containing luminogen in the presence of Zn2+. However, the terpyridine-containing luminogen displays a magenta color upon selectively binding with Fe2+. This allows easy identification of both Zn2+ and Fe2+ ions in aqueous media. The function of the polyenes can be easily tuned by altering the substituent groups. Due to their AIE properties, these polyenes can be used in aqueous solutions and in solid substrates for metal sensing.
    Type: Application
    Filed: September 4, 2012
    Publication date: March 7, 2013
    Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Benzhong TANG, Yuning HONG, Wai Tung LEUNG
  • Patent number: 8383362
    Abstract: A fixative for biological tissue made up of polymerized carbon nanotubes encapsulating osmium nanoparticles and its method of synthesis are disclosed. Carbon nanotubes are first oxidized. Next, the oxidized carbon nanotubes and monohydrated citric acid are mixed to synthesize carbon nanotubes grafted with poly(citric acid). The carbon nanotubes grafted with poly(citric acid) are then mixed with an osmium source to synthesize carbon nanotubes grafted with poly(citric acid) encapsulating osmium nanoparticles. The nano-fixative of this application has been shown to improve fixation of biological tissue relative to well-known fixatives.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: February 26, 2013
    Inventors: Nahid Sarlak, Mostafa Karimi
  • Patent number: 8343771
    Abstract: Measuring the concentration of an analyte in an aqueous solution by obtaining an aqueous solution containing an analyte, providing a cyanine indicator, placing the aqueous solution in fluid communication with the cyanine indicator, measuring a detectable property change of the cyanine indicator, and comparing the detectable property change of the cyanine indicator with a calibration curve of the detectable property change of samples containing known concentrations of the analyte. The concentration of the analyte is determined using the detectable property change that is proportional to the concentration of the analyte in the aqueous solution.
    Type: Grant
    Filed: January 12, 2011
    Date of Patent: January 1, 2013
    Assignee: General Electric Company
    Inventors: Bingzhi Chen, Caibin Xiao, Hong Xu, Alan M. Agree, Chunbo Yu
  • Publication number: 20120309095
    Abstract: Compositions containing polyanthrylene and methods of making these compositions are disclosed herein. The polyanthrylene composition can, for example, be used for detection of iron in a sample.
    Type: Application
    Filed: April 7, 2011
    Publication date: December 6, 2012
    Applicant: TONGJI UNIVERSITY
    Inventors: Mei-rong Huang, Shao-jun Huang, Jiang Ying Li, Xin-gui Li
  • Publication number: 20120288947
    Abstract: The present invention discloses a fluorescent probe compound which solved the problem of fluorescence quenching by Pd2+, and its preparation method and use as well. Excitation and emission wavelengths of the probe compound are in visible light region. The probe compound is highly sensitive and displays good selectivity for Pd2 in near-neutral pH range. In detection of Pd2 in 0-10 ppb level, fluorescence is evidently enhanced, and Pd2 in the level as low as 5 nM can be detected. Fluorescence intensity is well linearly correlated to Pd2 concentration. The probe compound can be used for detection of contaminating palladium and residual palladium in drug, soil, water sample and reactor.
    Type: Application
    Filed: December 6, 2010
    Publication date: November 15, 2012
    Applicants: DALIAN CHROMAS BIOSCIENCE CO., LTD, DALIAN UNIVERSITY OF TECHNOLOGY
    Inventors: Xiaojun Peng, Jiangli Fan, Honglin Li, Jingyun Wang, Shiguo Sun
  • Patent number: 8309361
    Abstract: This disclosure relates to a method for detecting at least one analyte in a tetrachloride sample comprising titanium, tin or silicon tetrachloride; comprising, (a) adding a mixture of water and acid, typically hydrochloric acid, to the sample under conditions effective for forming an aqueous solution of the sample; (b) introducing the aqueous solution of the sample into an inductively coupled mass spectrometer having a cell selected from the group of a reactive cell and a collision cell or both and producing an analyte ion comprising an interfering species; (c) contacting the analyte ion with a gas to produce a product which is substantially free from the interfering species; and (d) detecting and measuring at least one signal from the analyte in the solution. This disclosure further relates to a method for making an aqueous titanium, tin or silicon tetrachloride sample suitable for analysis in using inductively coupled plasma mass spectroscopy.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: November 13, 2012
    Assignee: E I du Pont de Nemours and Company
    Inventors: Lisa Edith Helberg, Jane Ramsey Marsh, Craig Steven Westphal
  • Patent number: 8293534
    Abstract: A method for quantifying the permanganate-reducing compounds (PRCs) in an acetic acid sample is disclosed. The method comprises establishing a correlation between permanganate absorbances of standard samples and their PRC contents and determining the PRC content of the acetic acid sample by measuring its permanganate absorbance of a reaction mixture containing a standard permanganate solution and the acetic acid sample. The permanganate absorbance is obtained by subtracting the manganese dioxide absorbance from the absorbance of the mixture.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: October 23, 2012
    Assignee: Lyondell Chemical Technology, L.P.
    Inventor: Noel Hallinan
  • Patent number: 8278111
    Abstract: Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal orientation or both; and wherein C1 and C2 are the same or different; and wherein C1 and C2 individually are chosen from a cysteine and a cysteine-like nonnatural amino acid, as well as metal-XC1C2 complexes and methods for forming such complexes.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: October 2, 2012
    Assignee: University of Kansas
    Inventors: Jennifer Ann Stowell Laurence, Anthony Andrew Vartia, Mary Elizabeth Krause
  • Patent number: 8273576
    Abstract: The present invention relates to a molecular-based system for the optical detection, quantification and detoxification of hexavalent chromium (Cr6+) by reversible metal-substrate electron transfer. More particularly, the invention provides a Cr6+ sensor device comprising a divalent osmium (Os2+)-, iron (Fe2+)- or ruthenium (R2+)-based pyridyl complex capable of changing its oxidation state in response to a reduction of Cr6+ at the presence of H+, thereby causing a reversible and optically readable change in optical properties of said complex. The Os2+-, Fe2+- or R2+-based pyridyl complex used according to the invention can be used for selective detection and quantification of Cr6+, as well as for catalytic detoxification of Cr6+.
    Type: Grant
    Filed: February 1, 2009
    Date of Patent: September 25, 2012
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Milko E. Van Der Boom, Tarkeshwar Gupta, Graham De Ruiter
  • Publication number: 20120232098
    Abstract: The invention provides methods for treatment of acute coronary syndrome and prediction of adverse cardiac events on the basis of elevations of catalytic iron in biological fluid of a human subject. An embodiment of the invention provides a method for early detection of acute coronary syndrome (ACS) in a human subject at the time of presentation of the chest pain. The method includes analyzing a test sample of the biological fluid for amount of catalytic iron and detecting acute coronary syndrome in the human subject.
    Type: Application
    Filed: May 21, 2012
    Publication date: September 13, 2012
    Inventors: Mohan Rajapurkar, Suhas Lele, Sudhir Shah
  • Patent number: 8263410
    Abstract: Disclosed is an innovative method for detecting metal ions based on selective plasmonic resonance energy transfer between metal-ligand complexes and a single nanoplasmonic particle as a probe. The selective plasmonic resonance energy transfer occurs if a resonance frequency matching condition between the single nanoplasmonic particle and the metal-ligand complexes is satisfied.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: September 11, 2012
    Assignees: Industry-University Cooperation Foundation Sogang University, University of California, Berkeley
    Inventors: Taewook Kang, Luke P. Lee, Yeonho Choi, Younggeun Park
  • Patent number: 8222038
    Abstract: A method for analyzing a metal specimen includes an electrolysis step of electrolyzing a metal specimen containing a reference element and a target element in an electrolytic solution, a sampling step of sampling a portion of the electrolytic solution, an analysis step of analyzing the sampled electrolytic solution, a concentration ratio-calculating step of calculating the concentration ratio of the target element to the reference element in the electrolytic solution on the basis of the analysis results, and a content-calculating step of calculating the content of the target element present in the form of a solid solution by multiplying the content of the reference element in the metal specimen by the obtained concentration ratio.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: July 17, 2012
    Assignee: JFE Steel Corporation
    Inventors: Satoshi Kinoshiro, Tomoharu Ishida
  • Publication number: 20120178171
    Abstract: The present invention concerns a method of measuring the concentration of an analyte in an aqueous solution that comprises the steps of: obtaining an aqueous solution containing an analyte, providing a cyanine indicator, placing the aqueous solution in fluid communication with the cyanine indicator, measuring a detectable property change of the cyanine indicator, and comparing the detectable property change of the cyanine indicator with a calibration curve of the detectable property change of samples containing known concentrations of the analyte to determine the concentration of the analyte, wherein the detectable property change is proportional to the concentration of the analyte in said aqueous solution.
    Type: Application
    Filed: January 12, 2011
    Publication date: July 12, 2012
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Bingzhi Chen, Caibin Xiao, Hong Xu, Alan M. Agree, Chunbo Yu
  • Patent number: 8216849
    Abstract: A method and kit for determining a concentration of iron in brake fluid when contacting a colorimetric reagent such that a color results. The level of iron can be used to determine the amount of active corrosion within a brake system and determine if special service procedures are required.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: July 10, 2012
    Inventor: Jon A. Petty
  • Publication number: 20120142115
    Abstract: The invention provides a method and apparatus for determining the amount of various materials in a liquid sample. Because the apparatus is particularly resilient it can be used repeatedly with very harsh liquid samples such as boot water from an oil refinery. The apparatus uses at least one volume and/or concentration independent optical analysis method to determine at least one of: the pH, amount of chloride, and/or amount of iron in the sample. The optical property can be colorimetric, fluorescent or both and result from adding dyes, complexing agents, turbidity inducing compounds, and other optically effecting reagents to the sample. Because the measurements are concentration and volume independent they can be done continuously, quickly, and avoid the inconvenient start and stop procedures in prior art measurement regimens.
    Type: Application
    Filed: April 27, 2011
    Publication date: June 7, 2012
    Inventors: Rodney H. Banks, Steven R. Ciota, Sascha J. Welz
  • Publication number: 20120142113
    Abstract: The invention provides a method and apparatus for determining the amount of various materials in a liquid sample. Because the apparatus is particularly resilient it can be used repeatedly with very harsh liquid samples such as boot water from an oil refinery. The apparatus uses at least one volume and/or concentration independent optical analysis method to determine at least one of: the pH, amount of chloride, and/or amount of iron in the sample. The optical property can be colorimetric, fluorescent or both and result from adding dyes, complexing agents, turbidity inducing compounds, and other optically effecting reagents to the sample. Because the measurements are concentration and volume independent they can be done continuously, quickly, and avoid the inconvenient start and stop procedures in prior art measurement regimens.
    Type: Application
    Filed: December 1, 2010
    Publication date: June 7, 2012
    Inventors: Rodney H. Banks, Steven R. Ciota, Sascha J. Welz