Diverse Hetero Atoms In Same Or Different Rings (e.g., Alkaloids, Opiates, Etc.) Patents (Class 436/92)
  • Publication number: 20150132746
    Abstract: Provided herein is technology relating to the collection of biological samples and particularly, but not exclusively, to compositions, methods, and uses related to using a biopolymer substrate to collect biological samples for analysis.
    Type: Application
    Filed: May 29, 2013
    Publication date: May 14, 2015
    Inventors: Astrid Gjelstad, Lars Erik Eng Eibak, Anne Bee Hegge, Knut Einar Rasmussen, Stig Pedersen-Bjergaard
  • Patent number: 8947516
    Abstract: A method of imaging microscopic objects includes determining the relative depths of two or more semiconductor nanocrystals by analyzing images of the semiconductor nanocrystals at varying z-displacements.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: February 3, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Hao Huang, Yu Yao, C. Forbes Dewey, Moungi G. Bawendi
  • Publication number: 20150017732
    Abstract: A colorimetric assay to detect certain compounds and a kit therefore are provided.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 15, 2015
    Inventors: Tsunghsueh Wu, Charles Cornett
  • Publication number: 20150017733
    Abstract: The present invention provides methods for detecting and quantifying metabolites in a biological sample by measuring the concentration of a test metabolite in the sample and comparing that concentration against the concentration of the reference metabolite; enabling accurate metabolite concentration measurements to determine aberrant drug usage patterns. Also disclosed is an analytical testing device and related computer-assisted products for detecting and quantifying metabolites in a biological sample efficiently and accurately.
    Type: Application
    Filed: August 12, 2014
    Publication date: January 15, 2015
    Applicant: MARSHFIELD CLINIC, INC.
    Inventors: Michael E.M. Larson, Thomas M. Richards
  • Publication number: 20150004710
    Abstract: Reagents and methods are disclosed for detection of oxidizers and inorganic salts and other analytes of interest. The reagents can interact with their target analytes, especially oxidizer compositions or oxidizer-based explosives, to selectively enhance their ionization yield, interacting by chemical reaction or by forming an associative adduct which facilitates their detection. For example, the reagents can adduct with the counter-ion of the intended analyte for improved direct detection and/or react chemically via acid-base reactions to produce a new product for detection. In another aspect of the invention, reactive reagents and methods are also disclosed that facilitate indirect detection of the analyte at lower temperatures based on reduction-oxidation (redox) chemistry. These reagents are particularly useful in detecting oxidizer analytes.
    Type: Application
    Filed: July 23, 2013
    Publication date: January 1, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: Kerin E. Gregory, Roderick R. Kunz, Michael Sworin
  • Patent number: 8912003
    Abstract: Methods for quantitative determination of the presence of isothiazolone compounds in a solution include controlling pH of the solution in a range from about 3 to about 10, combining a known quantity of the pH-adjusted solution with a known quantity of an aromatic thiolate anion, quantitatively determining color intensity of the resultant combined solution; and correlating the color intensity with amount of isothiazolone compounds. The methods may be used in automated systems, including systems utilizing optical sensor devices.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: December 16, 2014
    Assignee: General Electric Company
    Inventor: David James Monk
  • Patent number: 8835641
    Abstract: Novel fluorescent markers of Formula I: are disclosed herein, wherein X and Y are independently or together absent or are independently selected from R and R1 are independently selected from H and alkyl; Ar is phenyl or heteroaryl; L is absent or a spacer selected from the group consisting of —NH—; —(CH2)nNH—; —NHSO2—; —(CH2)nNHCO—; -(cycloalkyl)NHCO—; —(CH2)nNHSO2—; -(cycloalkyl)NHSO2—; —CONH(CH2)nNHCO—; —CONH(cycloalkyl)NHCO—; —NHCO(CH2)nNHCO—; —NHCO(cycloalkyl)NHCO—; —(CH2)nSO2NH—; -(cycloalkyl)SO2NH—; —(CH2)nNHCSNH—; -(cycloalkyl)NHCSNH—; —CR?CR1—; —C?C—; —(CH2)nN?CH—; -(cycloalkyl)N?CH—; —N?CH(CH2)—; —N?CH(cycloalkyl)-; n is an integer ranging from 1 to 5; F is a fluorophore selected from the group consisting of fluorescein, rhodamine, eosin, thionine, safranin, coumarin, methoxycoumarin, dansyl, BODIPY and BODIPY derivatives; and wherein X, Y and L may be positioned in a 1,3,5; 1,2,3; 1,3,4 or in a 3,4,5 configuration respectively.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: September 16, 2014
    Assignee: University of Ottawa
    Inventors: Jeffrey Keillor, Karine Caron
  • Patent number: 8765481
    Abstract: A method of detecting a peroxidic explosive includes providing a sample which may comprise the peroxidic explosive. A mixture comprising at least one ionic liquid and at least one volatile organic solvent is provided. The sample is taken up in the mixture so as to provide a sample for detection. The sample for detection is analytically detected so as to determine whether it includes the peroxidic explosive.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: July 1, 2014
    Assignee: Rheinische Friedrich-Wilhelms-Universitaet Bonn
    Inventors: Siegfried Waldvogel, Carsten Siering, Daniel Lubczyk
  • Publication number: 20140147925
    Abstract: The present invention provides a method for profiling phytohormone levels in plant tissue or tissue of other plastid containing organisms, i.e. a method for the simultaneous determination of a multitude of phytohormone levels in plant tissue or tissue of other plastid containing organisms, which method comprises the following steps: i. extraction of particulate tissue material of the plastid containing organism, in particulate tissue material of plants, with a liquid extractant, which is a mixture of at least one water miscible neutral organic solvent having from 1 to 3 carbon atoms and 1 heteroatom selected from O and N with water containing from 0.1 to 5% by weight, based on the extractant, of at least one acid, whereby a first liquid extract is obtained; ii. contacting the liquid extract obtained in step i. with a solid absorbent having a hydrophobically modified surface and removing the solid absorbent to obtain a second liquid extract; iii.
    Type: Application
    Filed: April 13, 2012
    Publication date: May 29, 2014
    Applicant: BASF PLANT SCIENCE COMPANY GMBH
    Inventors: Regine Fuchs, Martin Dostler, Maria Wahl, Benjamin Hentschel, Ralf Looser
  • Publication number: 20140120628
    Abstract: Embodiments of near-infrared (NIR) dyes are disclosed, along with methods and kits for detecting analytes with the NIR dyes. The NIR dyes have a structure according to the general structure At least one of R1/R2, R2/R3, R3/R4, R5/R6, R6/R7, and/or R7/R8 together forms a substituted or unsubstituted cycloalkyl or aryl.
    Type: Application
    Filed: June 29, 2012
    Publication date: May 1, 2014
    Applicant: The Oregon State Board of Higher Education on Behalf of Portland State University
    Inventors: Robert Michael Strongin, Martha Sibrian-Vazquez, Jorge Omar Escobedo-Cordova, Mark Allen Lowry
  • Publication number: 20130323286
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Application
    Filed: November 7, 2012
    Publication date: December 5, 2013
    Applicant: PROGENICS PHARMACEUTICALS, INC.
    Inventor: Progenics Pharmaceuticals, Inc.
  • Publication number: 20130309775
    Abstract: It is a subject of the present invention to provide a novel polymer; a filler for measuring a perfluoro compound having an acidic group at terminal which comprises said polymer; a column filled with said filler; and a measuring method for a perfluoro compound having an acidic group at terminal by using said column; as well as a filler for measuring a drug comprising the above-described polymer; a column filled with said filler; and a measuring method for a drug by using said column.
    Type: Application
    Filed: July 24, 2013
    Publication date: November 21, 2013
    Applicants: Nippon Filcon Co., Ltd., Wako Pure Chemical Industries, Ltd.
    Inventors: Yoshinori Inoue, Kimiko Yoshida, Mamoru Kubota, Hitoshi Uemori
  • Patent number: 8465985
    Abstract: A fluorescent probe comprising a compound represented as (Fluorophore A)-S-(Fluorophore B) (Fluorophore A and Fluorophore B are fluorophores which emit fluorescence when they are irradiated with an excitation light of a wavelength of 600 to 950 nm, Fluorophore A has a property that it shows change of fluorescence characteristic before and after a specific reaction with an substance to be measured, and S represents a spacer which connects Fluorophore A and Fluorophore B), which compound shows substantial change in efficiency of fluorescence resonance energy transfer between Fluorophore A and Fluorophore B before and after the specific reaction with the objective substance, wherein Fluorophore A is represented by the following formula (AI): which uses and shows an excitation light wavelength/fluorescence wavelength in the near infrared region, lights of which region show superior biological tissue permeability, and enables measurement of an substance to be measured by the ratio method.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: June 18, 2013
    Assignee: The University of Tokyo
    Inventors: Tetsuo Nagano, Hirotatsu Kojima, Sakiko Aizawa, Kazuki Kiyose
  • Patent number: 8455265
    Abstract: A surface grafted conjugated polyelectrolyte (CPE) is formed by coupling a CPE by a coupling moiety to the surface of a substrate. The substrate can be of any shape and size, and for many uses of the surface grafted CPE, it is advantageous that the substrate is a nanoparticle or microparticle. Surface grafted CPEs are presented that use silica particles as the substrate, where a modified silane coupling agent connects the surface to the CPE by a series of covalent bonds. Two methods of preparing the surface grafted CPEs are presented. One method involves the inclusion of the surface being modified by the coupling agent and condensed with monomers that form the CPE in a grafted state to the substrate. A second method involves the formation of a CPE with terminal groups that are complimentary to functionality that has been placed on the surface of the substrate by reaction with a coupling agent. The surface grafted CPEs are also described for use as biosensors and biocides.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: June 4, 2013
    Assignee: STC.UNM
    Inventors: David G. Whitten, Sireesha Chemburu, Thomas Corbitt, Linnea Ista, Gabriel Lopez, Kirk S. Schanze, Motokatsu Ogawa, Eunkyung Ji
  • Publication number: 20130137183
    Abstract: A method of screening aircraft passengers and/or cargo comprising loading an aircraft with passengers, cargo or both, circulating air within the aircraft so that the air is in contact with the passengers and/or cargo, expelling some of the circulated air from the aircraft, diverting a portion of the air being expelled from the aircraft through a chemical filter configured to retained evidence of a target substance, and analyzing the chemical filter to detect the presence of a target substance within the aircraft.
    Type: Application
    Filed: November 26, 2012
    Publication date: May 30, 2013
    Applicant: Teknoscan Systems, Inc.
    Inventor: Teknoscan Systems, Inc.
  • Publication number: 20130109103
    Abstract: A method of detecting a peroxidic explosive includes providing a sample which may comprise the peroxidic explosive. A mixture comprising at least one ionic liquid and at least one volatile organic solvent is provided. The sample is taken up in the mixture so as to provide a sample for detection. The sample for detection is analytically detected so as to determine whether it includes the peroxidic explosive.
    Type: Application
    Filed: June 16, 2011
    Publication date: May 2, 2013
    Applicant: RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN
    Inventors: Siegfried Waldvogel, Carsten Siering, Daniel Lubczyk
  • Patent number: 8426213
    Abstract: The present invention relates to providing improved hydrogen peroxide assays, as well as droplet actuators for conducting such assays. The droplet actuators of the invention may be used to conduct droplet-based hydrogen peroxide assays. They may also be associated with detectors for analyzing the results of the hydrogen peroxide assays of the invention. They may be provided as components of systems which control droplet operations and/or detection for conducting the hydrogen peroxide assays. Measurement by the detector may be used to quantify the presence of an analyte in a sample.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: April 23, 2013
    Assignee: Advanced Liquid Logic Inc
    Inventors: Allen E. Eckhardt, Vijay Srinivasan, Vamsee K. Pamula
  • Patent number: 8404488
    Abstract: The invention is provided for detection of Heroin and Morphine in illicit drug samples, also for their differentiation. A liquid sample from a street sample is prepared and divided into two equal aliquots, one of them being reference sample, another being main sample. Both samples are treated with Hydrochloric acid and Sodium hydroxide, but those substances are added to the samples in the different sequence. After that the measurement of SFS of the reference sample is performed. Further the presence of specific spectral pattern of Morphine in the measured SFS of the reference, sample is detected and the value of SFS intensity at the specific spectral point is fixed (a reference value). After 15 minutes for acidification of the main sample, the analogous measurement and detection of the Morphine in the main sample are performed.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: March 26, 2013
    Assignee: Nartest International AS
    Inventors: Sergey Babichenko, Tatjana Ivkina, Larisa Poryvkina, Vitaly Sominsky
  • Publication number: 20130052744
    Abstract: Methods for quantitative determination of the presence of isothiazolone compounds in a solution include controlling pH of the solution in a range from about 3 to about 10, combining a known quantity of the pH-adjusted solution with a known quantity of an aromatic thiolate anion, quantitatively determining color intensity of the resultant combined solution; and correlating the color intensity with amount of isothiazolone compounds. The methods may be used in automated systems, including systems utilizing optical sensor devices.
    Type: Application
    Filed: August 26, 2011
    Publication date: February 28, 2013
    Applicant: GENERAL ELECTRIC COMPANY
    Inventor: David James Monk
  • Publication number: 20130045501
    Abstract: A detection device for detecting analytes in liquid specimen is provided. The detection device comprises: a specimen chamber for collecting or storing a liquid specimen; a detecting chamber for containing a detecting element; and a through hole for transferring the liquid specimen between the specimen chamber and the detecting chamber. The through hole can be opened or self-sealed. The sealing or opening of the through hole controls whether or not the liquid specimen in the specimen chamber enters the detecting chamber via the through hole. Furthermore, a detection method is provided.
    Type: Application
    Filed: March 25, 2011
    Publication date: February 21, 2013
    Inventors: Lin Hu, Haipeng Hu, Yinfei Wu
  • Publication number: 20130004940
    Abstract: A device for detecting an analyte in a sample is provided, which comprises: a collecting chamber containing an opening for collecting a liquid sample; a detecting element for detecting an analyte in the liquid sample; and a lid for covering the opening of the collecting chamber. The device further comprises an indicating device thereon to indicate whether or not the lid covers at an appointed position. The operation of the device is very simple.
    Type: Application
    Filed: November 23, 2010
    Publication date: January 3, 2013
    Inventors: Haipeng Hu, Jianfeng Wang
  • Publication number: 20130004986
    Abstract: The present invention relates to the use of luminescent Ir(III) and Ru(II) complexes and their application in electro-chemiluminescence and bio-labelling. The use refers to the labelling and detection of biomolecules.
    Type: Application
    Filed: December 3, 2010
    Publication date: January 3, 2013
    Inventors: Luisa De Cola, Jesus Miguel Fernandez Hernandez, Francesco Paolucci
  • Publication number: 20120295362
    Abstract: My newly created invention consists of a means to test Synthetic Cannabanoids, By a urinalysis cup which a new reagent patch is added to the other patches being tested for drugs such as Marijuana, cocaine, methamphetamines, opiates and Heroin but not limited to the said illegal drugs. An equivalent would be a Saliva test that gives immediate results but is more expensive, hence the UA cup is more economical. The Synthetic Cannabanoid drug stays in your blood stream for approximately three days, so the need to detect it is substantial as it has proven very harmful to users as it mimic's marijuana but can be far more potent then THC, The active ingredient in Marijuana. The parent drugs of the synthetic Cannabanoids are JWH-018, JWH-073, and JWH 250 respectively and not intended to limit them to these chemicals for the purpose of testing for Synthetic Cannabanoids.
    Type: Application
    Filed: July 12, 2011
    Publication date: November 22, 2012
    Inventor: Todd Allen Bland
  • Publication number: 20120276644
    Abstract: Provided is a method for the real-time visualization of an endogenous biomolecule to clarify the mechanisms of various diseases and enable diagnosis and treatment of these diseases. Specifically provided is a novel method for visualizing an endogenous biomolecule by using a magnetic resonance method (including Overhauser MRI and the electron spin resonance method). The aforesaid visualization method, whereby an endogenous biomolecule is visualized on a real-time basis, comprises: a step for treating a living organism to be examined by a magnetic resonance method and thus acquiring data of the endogenous biomolecule; a step for processing the data of the endogenous biomolecule thus obtained to give imaging data; and a step for displaying the imaging data thus obtained.
    Type: Application
    Filed: October 29, 2010
    Publication date: November 1, 2012
    Applicant: Kyushu University, National University Corporation
    Inventors: Hideo Utsumi, Fuminori Hyodo, Kazuhiro Ichikawa
  • Patent number: 8287776
    Abstract: The present invention relates to a photochromic ink, the process for its preparation which is based on a spiropyran powder obtainable by melting, cooling and crushing, and to a new form of a spiropyran obtainable thereby. Said process to prepare a photochromic ink comprises the steps of a) heating and melting the spiropyran at a temperature below 250 C, b) cooling the melt to obtain a solidified spiropyran, c) crushing the solidified spiropyran to obtain a powder, d) optionally adding the powder to a binder providing the basis for the photochromic ink.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: October 16, 2012
    Assignee: BASF SE
    Inventors: Marc Maurer, Max Hügin, Thomas Raimann, Leonhard Feiler, Bruno Inderbitzin, André Fuchs
  • Patent number: 8273577
    Abstract: The present invention provides a phenothiazine-derivative color-measuring method that can detect a phenothiazine-derivative color even at a wavelength longer than the wavelength that exhibits maximum absorption.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: September 25, 2012
    Assignee: ARKRAY, Inc.
    Inventors: Satoshi Yonehara, Norio Inamura
  • Publication number: 20120220039
    Abstract: A method and system for detecting residual poison in human body are provided. Using the disclosed HPLC-Chip-mass spectrometry (MS)/MS and/or HPLC-MS/MS method to detect the residual poison, the method of the present invention mainly includes sample preparation, liquid chromatography and mass spectrometry. The method of the present invention has advantages of low sample size, high specificity, low detection limit, high sensitivity, low cost, high accuracy and stability, etc.
    Type: Application
    Filed: November 5, 2010
    Publication date: August 30, 2012
    Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Karl Wah Keung Tsim, Tina Tingxia Dong, Kevin Yue Zhu, Ka Wing Leung, Tiejie Wang
  • Publication number: 20120142545
    Abstract: A method for the equilibration of enriched isotope species and natural isotope species prior to mass spectrometric analysis using solid phase and/or microwave isotope ratio equilibration and measurement.
    Type: Application
    Filed: December 7, 2007
    Publication date: June 7, 2012
    Inventors: Howard M. Kingston, Mizanur Rahman, David Lineman, Mehmet Pamukcu
  • Patent number: 8183375
    Abstract: The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: May 22, 2012
    Assignee: Life Technologies Corporation
    Inventors: Zhenjun Diwu, Jixiang Liu, Kyle Gee
  • Publication number: 20120122819
    Abstract: The present invention includes novel compounds and pharmaceutically acceptable formulations of said compounds which exhibit antibiotic activity against microorganisms bearing a guanine riboswitch that controls the expression of the guaA gene, including organisms which are resistant to certain antibiotic families, and which are useful as antibacterial agents for treatment or prophylaxis of bacterial infections in animals or in humans, in particular but not limited to infections of the mammary gland, or their use as antiseptics, agents for sterilization or disinfection.
    Type: Application
    Filed: June 14, 2010
    Publication date: May 17, 2012
    Applicant: SOCPRA - SCIENCES ET GENIE S.E.C.
    Inventors: Jérôme Mulhbacher, Daniel Lafontaine, François Malouin, Marianne Allard, Eric Marsault
  • Publication number: 20110300567
    Abstract: A method for identifying the redox activity of a subject compound is disclosed. The method can be performed aerobically and can include forming a mixture comprising a free-radical precursor and a compound to be tested, and converting the free-radical precursor into a free-radical anion and a free-radical cation. After the free radical cation and the free radical anion have been formed, the relative redox activity of the subject compound may cause a difference in the rate of photo-bleaching of the mixture and/or the rate of superoxide generation. These differences can be quantified and used to identify the redox activity of the subject compound. This sensitive technique for measuring redox activity can be used to screen compounds for various biological applications. Drugs also can be developed based on the relationship between redox activity and biological activity for particular biological applications.
    Type: Application
    Filed: August 9, 2011
    Publication date: December 8, 2011
    Inventors: Jonathan J. Abramson, Benjamin S. Marinov
  • Publication number: 20110287549
    Abstract: The present invention relates to photochromic spiropyrans as active ingredients of Time-Temperature Indicators (TTIs), and to new spiropyrans per se. More particularly, the invention provides TTIs on the base of photochromic spiropyrans comprising alkylsulfanyl/arylsulfanyl substituents in the phenyl ring of the benzopyrane moiety.
    Type: Application
    Filed: February 9, 2010
    Publication date: November 24, 2011
    Applicant: FRESHPOINT HOLDINGS SA
    Inventors: Husein Salman, Elena Tenetov
  • Publication number: 20110269242
    Abstract: The present invention relates to time-temperature indicator (TTI) systems comprising indolenin based spiropyrans containing a cyclohexyl residue of formula (I), a method of manufacturing the time temperature indicator system, and a method of determining the time temperature history of perishable goods using the system. Moreover, the invention relates to a matrix selected from a printing ink or printing ink concentrate, paint, varnish, label, packaging material, and polymeric material comprising the system.
    Type: Application
    Filed: December 30, 2009
    Publication date: November 3, 2011
    Applicant: BASF SE
    Inventors: Hans Reichert, Max Hügin, Mathias Düggeli, Leonhard Feiler
  • Publication number: 20110217786
    Abstract: The present invention relates to a time temperature indicator comprising a spiropyran in a colored state and a modifier which is able to control the coloration and decoloration kinetics. The modifier which must be able to form with the spiropyran mixed solids with an amorphous, crystalline or mixed amorphous-crystalline structure.
    Type: Application
    Filed: May 2, 2011
    Publication date: September 8, 2011
    Inventors: Chandrasekhar Dayal Mudaliar, Neelesh Suresh Bahulekar, Anil Shanbhag, Suhas Dattatraya Shasrabudhe, Leonhard Feiler, Swati Shahsrabudhe
  • Patent number: 8008457
    Abstract: The structural design, preparative methods and chemical composition of two structural formulations of bivalent vaccines against morphine-heroin addiction (morphine-6-hemisuccinyl-EDC-TFCS-tetanus toxoid and 3-O-carboxymethylmorphine-EDC-TFCS-tetanus toxoid), are disclosed. These vaccines are suitable for human use in which they are capable of triggering the synthesis of polyclonal antibodies against morphine opiate and its structural analogue, heroin, through the repeated in vivo administration of these formulations, in active vaccination protocols, in pre-clinical studies in rodents. The active vaccination paradigm through which these immunogens trigger a humoral immune response consolidated with a long-term immunological memory, characterized by the presence of high titers of specific antibodies against these two drugs of abuse, is also disclosed.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: August 30, 2011
    Assignee: Instituto Nacional de Psiquiatria Ramon de la Fuente Muniz
    Inventors: Benito Anton Palma, Philippe Leff Gelman
  • Patent number: 7943388
    Abstract: Acoustic sensors, preferably surface acoustic wave sensors, and more preferably shear horizontal surface acoustic wave sensors that include soluble mixed with oligomers and/or polymers formed from such monomers), or multifunctional compounds, for example, that can function as either waveguide materials, immobilization materials for secondary capture agents (e.g., antibodies), or both.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: May 17, 2011
    Assignee: 3M Innovative Properties Company
    Inventors: John P. Baetzold, Karl E. Benson, G. Marco Bommarito, Michael P. Daniels, Albert I. Everaerts, Peggy-Jean P. Flanigan, M. Benton Free, Cary A. Kipke, Brinda B. Lakshmi, Charles M. Leir, George G. I. Moore, Lang N. Nguyen, Rahul R. Shah, Peter A. Stark
  • Patent number: 7939330
    Abstract: A fluorescent probe which specifically and efficiently traps nitrogen monoxide, zinc ion etc. to emit fluorescence is provided. A compound represented by the following general formula (I): [wherein R1 and R2 represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 to X4 represent hydrogen atom, an alkyl group, or a protective group for amino group, and m and n represent 0 or 1); R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R5 to R12 represent hydrogen atom, sulfo group, phospho group, a halogen atom, or a C1-6 alkyl group; R13 and R14 represent a C1-18 alkyl group; Z1 represents oxygen atom, sulfur atom, or —N(R15)— (wherein R15 represents hydrogen atom, or a C1-6 alkyl group); Y1 and Y2 represent —C(?O)—, —C(?S)—, or —C(R16)(R17) (wherein R16 and R17 represent a C1-6 alkyl group); and M? represents a counter ion in a number required for neutralizing the charge].
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: May 10, 2011
    Inventors: Tetsuo Nagano, Eita Sasaki, Hirotatsu Kojima, Tomoya Hirano, Kazuya Kikuchi
  • Publication number: 20110091997
    Abstract: An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water. The sample extracts resulting from use of each of these combinations have low vapor pressure and are compatible with immunochemistry assays.
    Type: Application
    Filed: December 29, 2010
    Publication date: April 21, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: FRANK C. GRENIER, RYAN F. WORKMAN, HINA SYED, SALMAN ALI
  • Patent number: 7927881
    Abstract: A method for detecting an analyze that may be present in ambient air, bound to a surface or as part of complex aqueous media that includes providing a metallole-containing polymer or copolymer, exposing the polymer or copolymer to a suspected analyze or a system suspected of including the analyze, and measuring a quenching of photoluminescence of the metallole-containing polymer or copolymer exposed to the system. Also included is a solid state inorganic-organic polymer sensor for detecting nitroaromatic compounds that includes a substrate and a thin film of a metallole-containing polymer or copolymer deposited on said substrate.
    Type: Grant
    Filed: August 25, 2005
    Date of Patent: April 19, 2011
    Assignee: The Regents of the University of California
    Inventors: William C. Trogler, Sara A Urbas, Sarah J. Toal, Jason Sanchez
  • Publication number: 20110086428
    Abstract: The present invention provides methods for detecting and quantifying metabolites in a biological sample by measuring the concentration of a test metabolite in the sample and comparing that concentration against the concentration of the reference metabolite; enabling accurate metabolite concentration measurements to determine aberrant drug usage patterns. Also disclosed is an analytical testing device and related computer-assisted products for detecting and quantifying metabolites in a biological sample efficiently and accurately.
    Type: Application
    Filed: July 26, 2010
    Publication date: April 14, 2011
    Inventors: Michael E.M. LARSON, Thomas M. Richards
  • Publication number: 20100330685
    Abstract: A compound represented by the following formula (I) or (II): wherein, in the formula (I), R1, R2, R3, and R4 independently represent methyl group or ethyl group; and in the formula (II), R5, R6, R7, and R8 independently represent methyl group or ethyl group and X? represents an anion, and a reagent for measurement of nitric oxide which comprises said compound.
    Type: Application
    Filed: June 29, 2010
    Publication date: December 30, 2010
    Applicants: SEKISUI MEDICAL CO., LTD.
    Inventors: Tetsuo Nagano, Hirotatsu Kojima, Kazuya Kikuchi
  • Patent number: 7833481
    Abstract: A fully integrated portable screening system includes a main housing and a contact pad. The contact pad is removably positioned in the main housing and covered by at least one sample sheet. The contact pad is preferably constituted by a cylindrical baton which carries a roll of sample collection sheets. A test subject interacts with the contact pad, leaving a trace sample on the sample collection sheet. The contact pad is then placed within the main housing and the trace sample is exposed to a test medium designed to interact with a specific analyte of interest potentially present in the trace sample. After exposure to the test medium, the sample sheet is subjected to a testing mechanism which exposes any interaction between the test medium and the analyte of interest to produce a test result.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: November 16, 2010
    Assignee: RedXDefense, LLC
    Inventors: Khaled F. Eltomi, Jack Kotowicz, Pratheev Sabaratnam Sreetharan, Regina Elvira Dugan
  • Publication number: 20100279420
    Abstract: A stabilised thylakoid membrane formulation comprising thylakoid membranes in a buffered solution and liposomes, wherein the formulation has a ratio of chlorophyll/liposomes of at least about 10:1. The invention further comprises a method for detecting or quantifying the presence of toxic molecules in a fluid sample, comprising obtaining a stabilised thylakoids membranes formulation; and assessing the photosynthetic efficiency of the thylakoid membranes formulation in the presence of said sample, whereby the molecules are detected when the photosynthetic efficiency is measurably different in the presence versus in the absence of the sample. The present invention also comprises kits using the stabilised thylakoid membranes formulation for detecting and/or quantifying the toxic molecule in a fluid sample.
    Type: Application
    Filed: April 21, 2010
    Publication date: November 4, 2010
    Inventors: François BELLEMARE, Nathalie Boucher, Lucie Lorrain
  • Publication number: 20100267068
    Abstract: Process for determination of a drug or medicament or their metabolites in a (body) fluid or an extract of (body) tissue or (body) sample comprising the steps: (i) optionally treatment of the fluid or sample extract with at least one enzyme, (ii) contacting at least a first part of the fluid or extract with at least one first solid phase able to adsorb or absorb organic compounds out of the fluid or extract, and/or (iii) contacting at least a second part of the fluid or extract with at least one second phase, able to extract or adsorb organic compounds out of the fluid or extract, and/or (iv) optionally contacting at least a third part of the fluid or extract with a liquid phase able to extract organic compounds out of the fluid or extract, and/or (v) desorbing the compound(s) bound to the first solid phase by applying heat to the solid phase and/or by solvent extraction, optionally followed by evaporating the solvent at least partially, (vi) optionally extracting or desorbing the compound(s) contained in or b
    Type: Application
    Filed: July 11, 2008
    Publication date: October 21, 2010
    Inventors: Douwe De Boer, Bert Kip, Ynze Mengerink, John Mommers, Roland Peters, Nicolle Reumkens
  • Publication number: 20100261747
    Abstract: The present invention provides a standardized method for the detection of narcotic abuse. Narcotics are formulated with a test compound that is not completely metabolized by the body. Narcotic diversion is detected by urinalysis of the suspected abuser, wherein the test compound may be detected even if the diverted narcotic is completely metabolized by the body, or otherwise undetectable in the urine.
    Type: Application
    Filed: December 17, 2008
    Publication date: October 14, 2010
    Inventor: Peter D. Winch
  • Patent number: 7731900
    Abstract: The present invention concerns a body fluid testing device (10) for analyzing a body fluids, comprising a test media tape (30) adapted to collect the body fluid, a supply portion (100) storing an uncontaminated section of the test media tape, a storage portion (110) for storing a contaminated section of the test media tape, an exposure portion positioned between the supply portion and the storage portion, the exposure portion being adapted to expose a section of the test media tape to the body fluid. An important aspect is a tip portion (20) for exposing a test medium to body fluid application. The application further concerns a test media cassette for housing test media. Another aspect is a testing device and method that employs illumination of a test medium at the site for body fluid application.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: June 8, 2010
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Hans-Peter Haar, Joachim Hoenes, Hans List, Maria Manser, Karl Miltner, Rudolf Pachl, Volker Zimmer
  • Publication number: 20090275062
    Abstract: The present invention relates to a method of extracting tacrolimus in a test blood sample to use in a tacrolimus quantification assay. The method of the present invention extracts tacrolimus in non-precipitating, non-denaturing aqueous environment, avoiding cumbersome manual pretreatment procedures or the use of organic solvents. The method of the present invention permits full automation of tacrolimus quantification assays.
    Type: Application
    Filed: May 11, 2009
    Publication date: November 5, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: John G. Konrath, David H. Wilson
  • Publication number: 20090253211
    Abstract: A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.
    Type: Application
    Filed: March 20, 2009
    Publication date: October 8, 2009
    Inventors: Shimon Weiss, Marcel Bruchez, Paul Alivisatos
  • Patent number: 7598385
    Abstract: The present disclosure provides the asymmetric cyanine fluorescent dyes of formula I in which X, n, R1, R2, R3, R4, R5 and Y? are as defined in the specification. The present disclosure also provides conjugates of the fluorescent dyes, methods for preparation thereof, compositions comprising the fluorescent dyes, and methods for staining biological samples using the fluorescent dyes and compositions thereof.
    Type: Grant
    Filed: December 31, 2007
    Date of Patent: October 6, 2009
    Assignee: Shenzhen Mindray Biomedical Electronics Co., Ltd.
    Inventors: Xiaojun Peng, Tong Wu, Jiangli Fan, Shiguo Sun, Bingshuai Wang, Bing Xu, Jianhui Shao
  • Publication number: 20090221585
    Abstract: Novel compounds and their uses are disclosed herein.
    Type: Application
    Filed: April 13, 2009
    Publication date: September 3, 2009
    Inventors: Stephen Ruckmick, Robert Cain, Milton J. Abreo, Massoud Fahid, Brent A. Johnson