Abstract: The invention relates to a washing device for cuvette sets. The cuvette set is placed into a holder (11) in a rotor (10). The washing liquid is removed from the cuvettes by rotating the rotor.

Abstract: The invention concerns a centrifugal separator with a rotor (15), in which a flexible member (28), e.g. a hose, extends a distance along the periphery of the rotor. The hose defines two parallel channels (29, 30), which form a separation chamber in the rotor and extend from the peripheral part of the rotor towards the rotor center; from there axially out of the rotor (15) at one axially directed side thereof, around the rotor to its opposite side and to a point (27) aligned with the rotor axis (C). During the operation of the rotor the hose may be rotated intermittently around its longitudinal axis relative to the rotor body, so that the radially inner and outer walls of the separation chamber are changing places.

Abstract: An apparatus and method of separating a component from a collected quantity of fluid. The apparatus includes a dual member centrifuge and an associated fluid flow transfer set. The transfer set has a collection container in which a quantity of fluid can be initially accumulated. The collection container is formed as a disk-shaped plastic member with an elongated generally radially extending barrier member formed therein. A component collection container is in fluid flow communication with the disk-shaped container. The method provides for centrifugation of the collection container in the dual member centrifuge thereby separating out the selected fluid component. The component can then be pumped out of the collection container into the component accumulation container. The residual fluid can be sealed in the collection container for later use. The component collection container can be separated and sealed also for later use.

Abstract: A centrifugal processing system for cultured cellular suspensions comprises a reservoir for pooling a desired volume of the cellular suspension from a plurality of individual containers in which the cellular suspension have been cultured. A centrifugation chamber is provided operative in response to centrifugal force for separating the cellular suspension into a cellular component and a supernatant. Fluid is conveyed from the reservoir into the centrifugation chamber at a high flow rate exceeding 1 liter per minute. The cellular component and supernatant are collected from the centrifugation chamber.

Abstract: A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.

Abstract: This invention is a dual axis, continuous flow centrifuge apparatus and method. A centrifuge head rotates in a vertical orientation about a first axis which, in turn, is rotated in a horizontal plane about a second axis. The rotation of the centrifuge head is matched to the rotation of the second axis to cancel out any net rotation of flexible conduits attached to the centrifuge head. The nonrotating coupling of the conduits permits continuous flow through the centrifuge head in the absence of seals. An angled centrifuge chamber inside the centrifuge head provides a more rapid separation of the components in the liquid passing through the centrifuge head. The path of travel of a particle in a centrifuge chamber inside the centrifuge head follows a generally cycloidal path thereby undergoing a pulsatile centrifugal force component.

Abstract: A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis.

Abstract: An apparatus and method of separating a component from a collected quantity of fluid. The apparatus includes a dual member centrifuge and an associated fluid flow transfer set. The transfer set has a collection container in which a quantity of fluid can be initially accumulated. The collection container is formed as a disk-shaped plastic member with an elongated generally radially extending barrier member formed therein. A component collection container is in fluid flow communication with the disk-shaped container. The method provides for centrifugation of the collection container in the dual member centrifuge thereby separating out the selected fluid component. The component can then be pumped out of the collection container into the component accumulation container. The residual fluid can be sealed in the collection container for later use. The component collection container can be separated and sealed also for later use.

Abstract: The present invention provides an improved rotor for a centrifuge that operates by centrifugal elutriation. The rotor consists of a chamber assembly, a disk assembly, and a quick release mechanism. The chamber assembly is relatively light and it includes one or two separation chambers, tubing and a rotating seal. The disk assembly consists of the relatively heavy support structure. The two piece construction facilitates handling the parts of the rotor that generally need to be autoclaved. The chamber assembly has a novel structure that allows the rotor to easily be configured for operation with one or two chambers. The disk assembly has a unique strain relief that prevents structural cracking. The quick release mechanism is held in the latched position by centrifugal force during operation of the rotor.

Abstract: In a centrifugal separator a flexible member for the transport of liquid to or from a centrifuge rotor is arranged to rotate around a rotating rotor in the same direction as the rotor but with only half of its rotational speed. By such rotation the flexible member may be firmly connected with both the rotor and a stationary member without being twisted. According to the invention the flexible member has a high torsional stiffness, good tensile strength and an outside having good wear resistance. The casing comprises interplaited threads which may be metal or plastic, some of which extend helically with a certain pitch around the flexible member and others of which extend helically with an opposite pitch around the member. The interplaiting of the threads is such that the casing per se is axially compressible and expandable under radial expansion and compression, respectively. As mounted, the casing is axially expanded so that through radial compression it is in frictional engagement with the flexible member.

Abstract: There is disclosed a continuous type centrifugal separator having simple structure in which the completedly closed system is realized, and which is suitable for separating the heavy and light components of the blood and usable for washing the blood of the patient.

Abstract: A centrifugal apparatus, in particular a flow-through centrifugal apparatus for processing biological fluids in continuous fluid communication, has a flexible tube securely fixed to a rotatably processing chamber and a stationary terminal coaxially above said processing chamber, and being formed in a loop around the outer periphery of said processing chamber so as, in operation, to orbit said loop around said processing chamber at half the rotational speed thereof to avoid twisting or drilling of said tube. To guide said loop of tube in its orbital movement, a rotating frame is provided also rotating at half the speed of the processing chamber. The drive trains for said processing chamber and said rotating frame, respectively, each comprise an individual drive shaft each drivingly connected separate from the other to a drive motor. This avoids any necessity of reversal of rotational direction in the drive trains and allows for a compact and simple construction with a minimum of rotating masses.

Abstract: The device comprises a single needle circuit having lines for admitting whole blood drawn from a patient to a continuously rotating rotor, re-introducing red cells and collecting plasma, the lines being respectively connected to the three outlets of a coupling static block rigidly attached to the rotor, two photocell-lightsource assemblies being further provided for automatically cyclically switching over the blood pick up and red cells introduction steps in the device steady state condition of operation.

Abstract: A rotatable processing bowl assembly adapted for mounting in a centrifuge includes an umbilical tubing system formed of a plurality of individual flexible tubes each of which communicates with the processing bowl. Each tube has an exterior wall and includes a first portion extending adjacently from the bowl and a second portion which is spaced from the bowl. The exterior walls of the tubes are bonded together along their first portions so that the joined exterior walls collectively define the outer periphery of the tubing system along the first portions of the tubes. Preferably, the tubes are also wound to form a predetermined helical pattern along their first portions. This arrangement enhances the tubing system's durability and resistance to fatigue along the bonded together first portions, particularly at higher rotational speeds, and permits direct, facile connection of the free and unattached second portions with external apparatus.

Abstract: The disclosure is a disposable low-mass processing channel and multilumen tube system for operation with a 2.omega. sealless centrifuge in which the centrifuge rotor rotates at 2.omega. axially to a platform rotor rotating at 1.omega. and to a fixed axial clamp on the multilumen tube.The blood processing channel is equipped with several tube lumens for access to different blood fractions to be separated by the centrifuge action. The plastic lumen tube is supported at each end by plastic reinforcing tubes clamped at clamp ends and ending in thrust drive bearings at the free ends. The thrust drive bearings are arranged for rotation about the multilumen tube and for fixation with respect to slotted conical reinforcing tube receivers on the 1.omega. rotor.Centrifugal force fixes the thrust bearings in place within the slotted conical reinforcing tube receivers. The low-mass central portion of the multilumen tube is unsupported; in operation it flies free in a wide bend.

Abstract: A flow-through centrifuge free of rotating seals. The centrifuge includes a frame having three spaced apart horizontal plates which carry a central bowl, a countershaft and a tube-supporting hollow shaft. A motor is arranged to drive the frame at an angular velocity of .omega.. The countershaft is driven by a stationary pulley on the motor and drives the bowl at an angular velocity of 2.omega.. The motion of the countershaft is also transferred to the tube-supporting hollow shaft by a pulley coupling having a ratio which effects rotation of the hollow shaft, with respect to the frame, at an angular velocity of -.omega..

Abstract: Apparatus for separating a liquid, such as whole blood, into fractions having different densities includes a separation chamber and a transfer device, such as a continuous piece of flexible tubing, for supplying the liquid to the separation chamber and discharging the liquid fractions therefrom. The separation chamber and the transfer device are conjointly rotated about a first axis which passes through a stationary end of the transfer device, while being simultaneously and conjointly rotated about a second axis which is coincident with a medial longitudinal axis of the rotating end of the transfer device so as to prevent the transfer device from twisting as a result of its rotation about the first axis.