Including Flexible, Removable Lining Therein Patents (Class 494/45)
  • Patent number: 9079194
    Abstract: The present invention relates generally to the field of extracorporeal blood processing methods and apparatus which are particularly useful in blood component collection, and more specifically, the present invention relates to methods and apparatus for centrifugally separating buffy coat that reduce the surface available for separated buffy coat components to sediment on by varying the radius of the product collection bag.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: July 14, 2015
    Assignee: Terumo BCT, Inc.
    Inventors: Dennis J. Hlavinka, John R. Merkling
  • Patent number: 9033858
    Abstract: An apparatus for use with a centrifugal cellular separation device that comprises a rotor rotatable about an axis of rotation is provided that comprises a fluid separation chamber having a first port, a second port spaced apart from the first port, and a third port located intermediate the first port and the second port. The fluid separation chamber has a cross sectional area generally transverse to a radius extending from the axis of rotation that varies between the first port and the second port. The fluid separation chamber is adapted to be mounted to the rotor so as to be rotatable therewith, with the first port located at a greater radial distance from the axis than the second port, and the third port located radially intermediate the first port and the second port.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: May 19, 2015
    Assignee: Fenwal, Inc.
    Inventor: Steven R. Katz
  • Patent number: 9000357
    Abstract: An apparatus and method to identify at least one component from a plurality of components in a fluid mixture, includes a first input channel containing the fluid mixture of components; at least one buffer input channel, into which at least one additional flow of buffer solution is introduced; a plurality of regions disposed at the other end of the apparatus, which are adapted to receive outputs of at least one selected component of the plurality of components, the selected component which is selectively removed from the first flow to one of the regions; a waste channel through which unselected components are removed from the first flow; a plurality of pumps connected to at least one reservoir, to control flow rates of the first flow and the additional flow(s); and a computer which controls a selection of one of the plurality of components from the fluid mixture.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: April 7, 2015
    Assignee: Premium Genetics (UK) Ltd.
    Inventors: Daniel Mueth, Joseph Plewa, Jessica Shireman, Amy Anderson, Lewis Gruber, Neil Rosenbaum
  • Patent number: 8992403
    Abstract: A cartridge (1) for accommodating blood bags (35) to be inserted into a centrifuge is used for the separation of blood components. Said cartridge (1) is provided with a partition wall (3) which separates a blood bag section (5) positioned radially inside from a product section (7) positioned radially outside, wherein a fixture (29) for a filter (31) is provided in the product section (7), a product transport path (36) which leads from the blood bag section (5) via the fixture (29) for the filter (31) to the product section (7). The product transport path (36) coming from the blood bag section (5) leads into the fixture (29) for the filter (31) radially from the outside and from below.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: March 31, 2015
    Assignees: Terumo BCT, Inc., Andreas Hettich GmbH & Co. KG
    Inventors: Klaus-Günter Eberle, Roland Biset
  • Patent number: 8950586
    Abstract: A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: February 10, 2015
    Assignee: Hanuman LLC
    Inventors: Randel Dorian, Richard W. Storrs, Scott R. King
  • Patent number: 8944983
    Abstract: An apparatus for separating at least two discrete volumes of a composite liquid into components, comprising a valve design that facilitates loading and unloading of sets of blood bags. The valves comprise a jaw mounted on a shaft, the jaw being adapted to apply radio frequency energy to seal a tube, a stepper motor section, and at least two position sensors. The valve sections are mounted on an upper plate, and the stepper motor sections are mounted on a lower plate. A main radio frequency coil is selectively electrically coupled to each of the valves through a multiplexing switch.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: February 3, 2015
    Assignee: Terumo BCT, Inc.
    Inventors: Hong Duc Nguyen, Bruce Ellingboe, Darryl Hudock
  • Publication number: 20150031521
    Abstract: The invention relates to a sample carrier centrifuge for a sample carrier (24) that has at least one sample channel (26) extending along an essentially central sample channel longitudinal axis (P), having a sample carrier receptacle (14), which can be rotated around a rotation axis (R) and has a holding section (38) into which the sample carrier (24) can be inserted in a loading procedure when the sample carrier receptacle (14) is not rotating, in which section the sample carrier (24) is held in the loaded state of the sample carrier receptacle (14), and from which section the sample carrier (24) can be removed in an unloading procedure, which is characterized in that a platform (22) of the sample carrier centrifuge (10), which is embodied for supporting the sample carrier centrifuge (10) in accordance with its designated use, is oriented parallel to the rotation axis (R).
    Type: Application
    Filed: February 6, 2013
    Publication date: January 29, 2015
    Inventors: Zhaoqiang Wang, Friedrich Neuhäusser-Wespy
  • Publication number: 20150024922
    Abstract: In one aspect, a disposable centrifuge includes a container including an interior compartment for receiving the liquid and solids. The container is capable of rotating to urge the solids toward the periphery of the interior compartment. A fixed extraction conduit may be provided for extracting at least a portion of the solids from adjacent the periphery of the interior compartment of the container. A motive device may also be provided for forming a non-contact coupling with the container, which may rotate and/or levitate the container. A relatively low, continuous flow rate (about 250 ml/min to about 500 ml/min) may also be utilized. Related methods are also disclosed.
    Type: Application
    Filed: February 2, 2013
    Publication date: January 22, 2015
    Inventors: Jose Antonio Castillo Gonzalez, Jean-Christophe Drugmand, Vishwas Pethe, Alexandre Terentiev
  • Patent number: 8933395
    Abstract: The present invention provides a method and apparatus to identify at least one component from a plurality of components in a fluid mixture, the apparatus including a first input channel into which a first flow containing a plurality of components is introduced; a plurality of buffer input channels, into which additional flows of buffer solution are introduced, disposed on either side of the first input channel; wherein the first flow and the additional flows have a flow direction along a length of the apparatus; a detector apparatus which detects and identifies selected components of the plurality of components; a laser which emits a laser beam which damages or kills selected components of the plurality of components; and at least one channel disposed at the another end of the apparatus which is adapted to receive the first flow and the additional flows after operation of the laser on the selected components.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: January 13, 2015
    Assignee: Premium Genetics (UK) Ltd.
    Inventors: Daniel Mueth, Joseph Plewa, Jessica Shireman, Amy Anderson, Lewis Gruber, Neil Rosenbaum
  • Publication number: 20140357465
    Abstract: Systems and methods are provided for processing blood or a fluid containing blood plasma and platelets. The blood or fluid is continuously added into a fluid separation chamber, which is used to isolate platelet-rich plasma therein. At least a portion of the platelet-rich plasma is automatically transferred from the fluid separation chamber into an injection device, with the fluid separation chamber and the injection device comprising components of a disposable flow circuit, which may be a closed system. One or more injection devices may be connected to a collection container or a pump device of the disposable flow circuit.
    Type: Application
    Filed: May 31, 2013
    Publication date: December 4, 2014
    Inventors: John W. Barry, JR., Brian C. Case, Jonathan Prendergast, Lan T. Nguyen, John Foley
  • Patent number: 8900112
    Abstract: A method for controlling a centrifuge blood component separation system for separating components of a blood product, the separation system comprising a centrifuge and a separation bag and at least one transfer bag. The method comprises selecting a nominal hematocrit value such that an actual hematocrit value is expected to be less than said nominal hematocrit; centrifuging a separation bag containing a volume of composite liquid so as to cause the sedimentation of at least a first component and a second component; transferring some of the first component to a first transfer bag; detecting time of passage of a red blood cell interface at a pre-selected location in the separation bag; and adjusting a predicted processing time based on the time of passage of the red blood cell interface.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: December 2, 2014
    Assignee: Terumo BCT, Inc.
    Inventors: Brian M. Holmes, Briden Ray Stanton, Geert Van Waeg, Mary Langley
  • Patent number: 8870734
    Abstract: The invention relates to a cartridge (1) for accommodating blood bags (35), which is provided for the separation of blood components for the application in a centrifuge. The cartridge (1) has a partition wall (3) which separates a blood bag section (5) positioned radially inside from a product section (7) positioned radially outside, and a cover (9) disposed in a mounting position above the blood bag section (5). The cover (9) is connected to the partition wall (3) pivotally in a first point (11) and detachably in a second point (13), so that the blood bag section (5) is freely accessible by means of laterally pivoting the cover (9) out of the way. The cartridge is applicable in the rotor of a centrifuge.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: October 28, 2014
    Assignees: Terumo BCT, Inc., Andreas Hettich GmbH & Co. KG
    Inventors: Klaus-Günter Eberle, Roland Biset
  • Patent number: 8840535
    Abstract: Method and apparatus for centrifugal blood component separation including temperature sensing in each of a plurality of separation cells. The temperature of unit of bloods over time is recorded. If the temperature of any of the units exceeds a pre-determined maximum, portions of the blood separation device may be cooled. A controller may determine which of the units to process first, generally proceeding from the warmest unit to the coolest. The order of unit processing may be changed during processing. The detected temperature may be used to calibrate a pressure sensor used to predict the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: September 23, 2014
    Assignee: Terumo BCT, Inc.
    Inventor: Victor D. Dolecek
  • Patent number: 8758210
    Abstract: An apparatus for performing a centrifugal field-flow fractionation is disclosed. In an embodiment of the invention, radial rotary shaft seals are used for sealing the rotating parts of the shaft for carrying out the centrifugal field-flow fractionation and the stationary parts. Furthermore, a separate line is introduced for reducing the pressure differential across these seals. In such way, the driving force driving sample fluid across the seals is reduced, thereby reducing leakage.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: June 24, 2014
    Assignee: Postnova Analytics GmbH
    Inventor: Roland Welz
  • Publication number: 20140087360
    Abstract: An insert for a centrifuge tube suitable for use in density gradient separation is described. The insert includes a member sized to fit within the tube for dividing the tube into a top portion and a bottom portion. Optionally the insert has a support extending or depending from the member for positioning the member within the tube. At least two openings are located on the member so that a first opening is closer to a bottom end of the tube relative to a second opening when the insert is positioned in the centrifuge tube. Also described are methods for separating a target population of cells from a sample using the insert for a centrifuge tube.
    Type: Application
    Filed: May 3, 2012
    Publication date: March 27, 2014
    Applicant: Stemcell Technologies, Inc.
    Inventor: Steven M. Woodside
  • Patent number: 8653442
    Abstract: The invention provides a method, apparatus and system for separating cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One exemplary method includes providing a first flow having a plurality of components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first cellular component of the plurality of components into the second flow while concurrently maintaining a second cellular component of the plurality of components in the first flow. The second flow having the first cellular component is then differentially removed from the first flow having the second cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: February 18, 2014
    Assignee: Premium Genetics (UK) Limited
    Inventors: Daniel Mueth, Joseph Plewa, Jessica Shireman, Amy Anderson, Lewis Gruber, Neil Harris Rosenbaum
  • Patent number: 8556793
    Abstract: Blood separation systems and methods are provided for controlling the interface between separated blood components. The system includes a blood separation chamber configured to separate blood into first and second blood components and an outlet line for removing at least a portion of the first blood component from the blood separation chamber. A primary optical sensor assembly is associated with the blood separation chamber to directly monitor the interior of the blood separation chamber. A secondary optical sensor assembly is associated with the outlet line to monitor the first blood component in the outlet line. The system also includes a controller programmed to select between the primary optical sensor assembly and the secondary optical sensor assembly for monitoring contamination of the first blood component. The system is particularly advantageous for preventing contamination of separated plasma which is lipemic or hemolytic.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: October 15, 2013
    Assignee: Fenwal, Inc.
    Inventors: John T. Foley, Lan T. Nguyen, Jonathan Prendergast, Jeffrey Maher, Christopher Mikkelson
  • Patent number: 8540614
    Abstract: An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising a valve design that facilitates loading and unloading of blood bags and associated tubing and bag sets. The valves comprise a rotating head, mounted on a shaft, which assumes a “load” position. The head pivots to an “open” position, which secures the tube in its designated location, but which maintains an open lumen through the tube. When the head is in a “closed” position, blood components cannot flow through the tube. The valve apparatus comprises means for maintaining a constant pressure on the tube and contact with the tube as the tube is melted and sealed.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: September 24, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Bruce Ellingboe, Hong Duc Nguyen
  • Patent number: 8535210
    Abstract: A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: September 17, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Jeremy P. Kolenbrander, Brian M. Holmes, Thomas J. Felt, James R. Ladtkow
  • Patent number: 8523750
    Abstract: A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and a method for controlling the blood processing apparatus comprising separating a blood component in a separation chamber; flowing the blood component out of the separation chamber and into a concentration chamber; concentrating the blood component in the concentration chamber; and flushing the blood component out of the concentration chamber. The method further comprising simultaneously flowing a solution, such as a wash solution or PAS, into the concentration chamber between the separation chamber and the concentration chamber.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: September 3, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: John Pittinger, Logan Fender
  • Patent number: 8474630
    Abstract: A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: July 2, 2013
    Assignee: Hanuman, LLC
    Inventors: Randel Dorian, Scott R. King, Richard Wood Storrs
  • Patent number: 8475352
    Abstract: A hermetically sealed solids discharge centrifugal separator having a separator bowl with a cylindrical upper portion and a conical lower portion, an inlet port at the bottom of the bowl and an outlet port at the top of the bowl. A disposable liner assembly includes a bowl liner having a cylindrical upper portion and conical lower portion, such that the bowl liner can conform to the interior surface of the separator bowl. The liner assembly further includes a piston within the bowl liner, the piston having an upper portion that conforms to the bowl liner cylindrical upper portion and a lower portion that conforms to the bowl liner conical lower portion. A fluid pathway extends through the piston, with a shuttle valve disposed within the fluid pathway.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: July 2, 2013
    Assignee: Wagner Development, Inc.
    Inventor: Robert B. Carr
  • Patent number: 8469202
    Abstract: A centrifugal processing bag, system and method for separating the components of a mixed material is presented. The processing bag includes a hub and a first port for receiving the mixed material, where the first port includes an outlet positioned within the processing bag at a perimeter of the bag. The processing bag also including a second port having a second port inlet spaced proximate the hub and away from a central axis of the hub. The second port directs a separated material collected from the second port inlet out of the processing bag.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: June 25, 2013
    Assignee: Velico Medical, Inc.
    Inventor: Keith M. Rosiello
  • Patent number: 8449439
    Abstract: A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making to the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: May 28, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Christopher Fletcher, William Sweat, Jeremy P. Kolenbrander, Aditya Dalvi, John R. Lindner
  • Patent number: 8425448
    Abstract: This invention is directed to a method of collecting and separating whole blood into components. The method includes the steps of adding an anticoagulant having an acidic pH to a bag for collecting and/or separating whole blood, collecting whole blood in the bag, loading the bag containing anticoagulated whole blood on a rotor, spinning the bag on the rotor to separate the whole blood into at least one component; and squeezing the bag on the rotor to push the component from the separation bag into at least one satellite bag.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: April 23, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas Felt, Peter Pihlstedt, Bruce Gibbs
  • Patent number: 8337379
    Abstract: A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity, or. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: December 25, 2012
    Assignee: Terumo BCT, Inc.
    Inventors: Christopher Fletcher, William Sweat, Jeremy Kolenbrander, Aditya Dalvi, John R. Linder
  • Patent number: 8337380
    Abstract: An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising a valve design that facilitates loading and unloading of blood bags and associated tubing and bag sets. The valves comprise a rotating head, mounted on a shaft, which assumes a “load” position. The head pivots to an “open” position, which secures the tube in its designated location, but which maintains an open lumen through the tube. When the head is in a “closed” position, blood components cannot flow through the tube. The valve apparatus comprises means for maintaining a constant pressure on the tube and contact with the tube as the tube is melted and sealed.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: December 25, 2012
    Assignee: Terumo BCT, Inc.
    Inventors: Bruce Ellingboe, Hong Duc Nguyen
  • Patent number: 8226537
    Abstract: A disposable blood separation set of a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber a baffle within a separation area. The baffle may have a plurality of vanes with openings therein. A protruding inlet may have a frustro-conical inner surface that slants radially outwardly from an inlet to a mouth of the protruding inlet. A circumferential well may surround the protruding inlet.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: July 24, 2012
    Assignee: Terumo BCT, Inc.
    Inventors: John Pittinger, Robert Langley, Mary Langley, legal representative, Logan Fender
  • Patent number: 8216120
    Abstract: A centrifuge (10) including a first rotatable mechanism (60) having a rotation axis with a fluid retentive housing (20) being coaxially mounted on the first rotatable mechanism for co-rotation therewith; a second rotatable mechanism (90) having a rotation axis with the first and second rotatable mechanisms being coaxially interconnected for co-rotation around a common axis; and fluid tubing (70) connected to the axis of the fluid retentive housing and having a distal length that extends axially outwardly from the fluid retentive housing. A support arm (50) is mounted to the second rotatable mechanism a support tube (80) receives therethrough at least a part of the distal length of the fluid tubing and a bearing member (82) rotatably supports the support tube in the support arm whereby upon rotation of the first and second rotatable mechanisms the fluid tubing is free to one of rotate with and rotate relative to the support tube.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: July 10, 2012
    Assignee: Velico Medical, Inc.
    Inventors: William Aitkenhead, Glen Jorgensen, Robert L. Standley
  • Patent number: 8187477
    Abstract: A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: May 29, 2012
    Assignees: Hanuman, LLC, Biomet Biologics, LLC
    Inventors: Randel Dorian, Scott R. King, Richard W. Storrs
  • Publication number: 20120129675
    Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
    Type: Application
    Filed: August 12, 2011
    Publication date: May 24, 2012
    Inventors: John E. Nash, William T. Fisher
  • Patent number: 8173027
    Abstract: Method for separating a volume of composite liquid into at least a first component and a second component including centrifuging a separation bag containing a volume of composite liquid and a volume of gas so as to sediment at least a first component and a second component separation bag; displacing a volume of hydraulic fluid against the separation bag to cause a transfer of at least one fraction of the content of the separation bag into at least one component bag connected to the separation bag; determining the volume of hydraulic fluid displaced and determining the volume of the composite liquid or the transferred components from the determined volume of displaced hydraulic fluid.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: May 8, 2012
    Assignee: Terumo BCT, Inc.
    Inventors: Niclas Högberg, Brian M. Holmes, Briden Ray Stanton, Lars Persson, Lars Strandberg, Peter Pihlstedt
  • Patent number: 8158927
    Abstract: The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: April 17, 2012
    Assignee: Arryx, Inc.
    Inventors: Daniel Mueth, Joseph Plewa, Jessica Shireman, Amy Anderson, Lewis Gruber, Neil Harris Rosenbaum
  • Publication number: 20120077663
    Abstract: A disposable device for the continuous centrifugal separation of a physiological fluid includes: a fixed axial element; a centrifugation chamber that can rotate around the axis of the element; an inlet channel for the blood to be centrifuged, whose dispensing port is close to the base of the chamber; and an outlet passage for a separated constituent, whose inlet port is close to the other end of the chamber in a concentrated area of one of the separated constituents having the lowest mass density in order to remove it continuously. The chamber takes the form of a long tube. The fixed axial element includes a second outlet passage for a second separated constituent, whose inlet port is close to the end of the chamber opposite the base in a concentrated area of the second separated constituent having the highest mass density in order to remove it continuously.
    Type: Application
    Filed: November 2, 2011
    Publication date: March 29, 2012
    Inventor: Jean-Denis ROCHAT
  • Patent number: 8133165
    Abstract: A flexible processing and/or expressor chamber for a biological cell processing apparatus is provided which may include a first side and a second side and having a expandable wall, wherein a first end of the expandable wall is attached to a circumference of the first side of the flexible chamber and a second end of the expandable wall is attached to a circumference of the second side of the flexible chamber. Either or both sides of the chamber may include an axial opening.
    Type: Grant
    Filed: January 4, 2010
    Date of Patent: March 13, 2012
    Assignee: Velico Medical, Inc.
    Inventor: Keith M. Rosiello
  • Publication number: 20120015795
    Abstract: The present invention relates generally to the field of extracorporeal blood processing methods and apparatus which are particularly useful in blood component collection, and more specifically, the present invention relates to methods and apparatus for centrifugally separating buffy coat that reduce the surface available for separated buffy coat components to sediment on by varying the radius of the product collection bag.
    Type: Application
    Filed: July 18, 2011
    Publication date: January 19, 2012
    Applicant: CARIDIANBCT, INC.
    Inventors: Dennis J. HLAVINKA, John R. MERKLING
  • Publication number: 20110319248
    Abstract: The present invention relates to a device that incorporates a single use centrifuge that is sterilized prior to use in the pharmaceutical, biopharmaceutical, biotechnology or related industries and is used for the removal of solids and/or other undesirable materials from one or more fluids and is connected to a bioreactor, fermentor, container or process by way of single use tubing, connectors and/or various fluid flow components.
    Type: Application
    Filed: September 2, 2011
    Publication date: December 29, 2011
    Inventor: Nathan Starbard
  • Patent number: 8070665
    Abstract: A method for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising centrifuging at least two separation bags containing two discrete volumes of a composite liquid respectively, so as to separate therein the first and second components; transferring at least one fraction of a first separated component from the separation bags into satellite bags connected thereto respectively; detecting a characteristic of a component at determined location in each separation bag; and stopping transferring the at least one fraction of the first component from each separation bag into the first satellite bag connected thereto, upon detection of the characteristic of a component at the determined location.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: December 6, 2011
    Assignee: CaridianBCT, Inc
    Inventors: Victor D. Dolecek, Daniel A. Joseph, Darryl Hudock
  • Patent number: 8057377
    Abstract: A bag loader for loading and unloading at least one satellite bag into and from the central compartment of a rotor of an apparatus for separating a composite liquid into at least two components comprises an upper part for removably securing an upper portion of at least one satellite bag; a lower part comprising a receptacle; and an intermediate part connecting the upper part to the lower part and exposing an intermediate portion of a satellite bag.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: November 15, 2011
    Assignee: CaridianBCT, Inc
    Inventors: Brian M. Holmes, Johan-Petter Hagström, Charles L. Hake
  • Publication number: 20110224064
    Abstract: A disposable blood separation set of a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber a baffle within a separation area. The baffle may have a plurality of vanes with openings therein. A protruding inlet may have a frustro-conical inner surface that slants radially outwardly from an inlet to a mouth of the protruding inlet. A circumferential well may surround the protruding inlet.
    Type: Application
    Filed: May 19, 2011
    Publication date: September 15, 2011
    Applicant: CaridianBCT, Inc.
    Inventors: John PITTINGER, Logan FENDER, Robert W. LANGLEY, Mary LANGLEY
  • Patent number: 7998052
    Abstract: A rotor having variable volumes adapted for collecting and centrifuging biological fluids including an impermeable flexible body having a cylindrical shape with stretchable vertical walls and semi pliant base and a rigid circular member seamlessly joined to the top of the flexible body.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: August 16, 2011
    Inventor: Jacques Chammas
  • Patent number: 7981019
    Abstract: An apparatus for separating a volume of composite liquid into at least a first component and a second component comprising a centrifuge having a rotor with a turntable for supporting a separation bag; a central compartment for containing satellite bags, and fitted with a support member for supporting at least one satellite bag so that a liquid contained in the supported satellite bag drains from the supported satellite bag into the separation bag under centrifugation forces when the rotor is set in rotation.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: July 19, 2011
    Assignee: CaridianBCT, Inc.
    Inventors: Brian M. Holmes, Johan-Petter Hagström
  • Patent number: 7976796
    Abstract: A centrifuge tube assembly includes an elongate tubular receptacle having a capped upper end. The capped upper end includes a single inlet/outlet port formed therethrough for communication with an interior of the tubular receptacle. A flexible aspiration pipe is communicably engaged with the inlet/outlet port for extending longitudinally through the cylindrical receptacle. A sealing diaphragm is attached to a distal end of the pipe. The diaphragm is longitudinally movable within the tubular receptacle and sealably interengages an interior wall of the receptacle. Biological products are introduced into and aspirated from the receptacle below the diaphragm by the fluid conducting pipe.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: July 12, 2011
    Assignee: Emcyte Corp.
    Inventors: Emery Smith, Patrick Pennie, David K. Buzenius
  • Patent number: 7963901
    Abstract: A disposable blood separation set of a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having a protruding inlet therein. The protruding inlet may have a frustro-conical inner surface that slants radially outwardly from an inlet to a mouth of the protruding inlet. A circumferential well may surround the protruding inlet. The cell separation chamber may have a baffle within a separation area. The baffle may have a plurality of vanes with openings therein.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: June 21, 2011
    Assignee: CaridianBCT, Inc.
    Inventors: Robert W. Langley, John Pittinger, Logan Fender
  • Patent number: 7947186
    Abstract: A rotor is provided for the centrifugal separation of a composite fluid, such as animal or human blood, into components. An inner surface of the rotor includes at least one hydrophobic area having a first surface energy sufficiently low to provide a flow path for a lower density fluid component to flow to the bottom of a central collection chamber after centrifugal separation. A method of separating a composite fluid into components using such a rotor is also provided. Additionally, a method of manufacturing such a rotor is provided.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: May 24, 2011
    Assignee: Statspin, Inc.
    Inventors: Todd W. Soares, Kevin Sullivan
  • Patent number: 7935043
    Abstract: A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, an outlet line and a storage solution line in fluid communication with the outlet line at a junction. The apparatus controls pumps to conduct a predetermined quantity of storage solution to a collected blood component. The apparatus also purges blood components in the tubing set by applying a negative pressure and positive pressure. A disposable blood processing set has a separation chamber; a tubing set including an inlet line in fluid and an outlet and a storage solution line connected to the outlet line at a junction.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: May 3, 2011
    Assignee: CaridianBCT, Inc.
    Inventor: Logan Fender
  • Patent number: 7918350
    Abstract: A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: April 5, 2011
    Assignee: Fenwal, Inc.
    Inventors: Kyungyoon Min, Richard I. Brown, Alp Akonur, Julie Moriarty
  • Patent number: 7857744
    Abstract: A cell separation set for separating blood components, having a cell separation chamber with a first entry section having a wall with an outwardly flared curve, the entry section having an axial length and an inmost maximum diameter perpendicular to the axial length, the axial length being greater than the inmost maximum diameter. The cell separation chamber further comprises a separation section having a wall comprising an inward curve. A transition section between the entry section and the separation section has a wall comprising a second inward curve, the second inward curve being different from said first inward curve. The first curve may be tangent to the second curve at a first junction between the first and second curves and the second curve may be tangent to the third curve at a second junction between the second and third curves.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: December 28, 2010
    Assignee: CaridianBCT, Inc.
    Inventors: Robert W. Langley, Linda A. Taylor, Timothy Michael Taga
  • Publication number: 20100311560
    Abstract: A collection device that captures liquid sample that may spill or leak during the process of loading or unloading liquid sample while a centrifuge rotor is spinning. Such capture prevents the leaked liquid sample from coming into contact with sensitive components inside the centrifuge chamber, thereby protecting the centrifuge from damage.
    Type: Application
    Filed: February 11, 2009
    Publication date: December 9, 2010
    Applicant: BECKMAN COULTER, INC.
    Inventor: Horst G. Krischer
  • Patent number: 7837884
    Abstract: A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: November 23, 2010
    Assignee: Hanuman, LLC
    Inventors: Randel Dorian, Scott R. King, Richard Wood Storrs